Dr. J. Satish Kumar, MD, Department of Basic & Medical Sciences, AUST General Medicine Renal System Name:_______________________________________ __ Learning Objectives: Describe the types, aetiology, pathogenesis, clinical manifestations, investigations & treatment of Glomerulonephritis, Acute Pyelonephritis, Nephrotic Syndrome, Chronic renal failure.
50
Embed
Dr. J. Satish Kumar, MD, Department of Basic & Medical Sciences, AUST
Name:_________________________________________. General Medicine Renal System. Learning Objectives: Describe the types, aetiology, pathogenesis, clinical manifestations, investigations & treatment of Glomerulonephritis, Acute Pyelonephritis, Nephrotic Syndrome, Chronic renal failure. - PowerPoint PPT Presentation
Welcome message from author
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Dr. J. Satish Kumar, MD, Department of Basic & Medical Sciences, AUST
c. mechanical stress(hemodynamic glomerular injury)
i. systemic hypertensionmalignant hypertension
massive fibrinoid necrosis of afferent arteriole and glomerulithrombotic microangiopathy
nephritic urinary sedimentacute renal failure
chronic sustained hypertensionarteriolar vasoconstriction and sclerosis
secondary glomerular and tubulointerstitial atrophy and sclerosis
c. mechanical stress(hemodynamic glomerular injury)
ii. glomerular hypertensionglomerular hypertension as an adaptive response to increased workload 2° to loss of other nephrons
sustained glomerular hypertension
increased mesangial matrix production
glomerulosclerosis
final common pathways of glomerular injury
1. secondary focal segmental glomerulosclerosis
2. tubulointerstitial inflammation and fibrosis (tubulointerstitial fibrosis)
final common pathways of glomerular injurysecondary focal segmental glomerulosclerosis
a. nephron losscompensatory changes in surviving nephrons
1. vasodilation of afferent arterioles2. glomerular hypertension3. glomerular hyperfiltration
sustained glomerular hypertension and hyperfiltrationTGF-β, angiotensin II, PDGF, CTGF, endothelins
accumulation of extracellular matrix
focal and segmental glomerulosclerosisglobal sclerosis proteinuria, hypertension,
progressive renal insufficiency
final common pathways of glomerular injurysecondary focal segmental glomerulosclerosis
b. glomerular hypertrophyintracapillary microthrombirecruited macrophageshyperlipidemia
glomerulosclerosis
Nephrotic syndrome-ifferential diagnosis of nephrotic and nephritic syndrome
Increased permeability of the basement membrane-podocyte system to albumine
Structural damage to the glomerulus due to inflammatory processes
21
NEPHROSIS NEPHRITIS
*Nephrotic syndrome is a group of symptoms including protein in the urine (more than 3.5 grams per day), low blood protein levels, high cholesterol levels, high triglyceride levels, and swelling.
• Supportive treatment• Treatment of steroid sensitive cases• Treatment of steroid resistant NS (FSGS)
29
Supportive tretment
• Restore plasma volume/decrease edema
• Decrease proteinuria
• Prevent renal damage
30
Supplementary measures
• Sodium restriction• Protein restriction 1g/kg + losses– Decreases proteinuria– Decreases sodium retention– Decreases the danger of development of secondary FSGS– Decreases the compensatory protein synthesis of the liver
– Intrinsic Renal Disease• Usually glomerular disease• Usually leads to End Stage Renal
Disease
Chronic Renal Failure-Definition
• CRF is defined as a permanent reduction in glomerular filtration rate (GFR) sufficient to produce detectable alterations in well-being and organ function. This usually occurs at GFR below 25 ml/min.
• About 100 to 150 per million persons in the U.S. develop CRF annually
• Average annual cost is $25,000 – 35,000 per patient per year
• Progressive and irreversible deterioration in glomerular +/- tubular function measured over months and years
Chronic Renal Failure-Causes• Diabetic Nephropathy– Diabetes most common contributor to ESRD
• Hypertension– CFR with Hypertension causes 23% of ESRD annually
• Glomerulonephretis: 10%• Polycystic Kidney Disease: 5%• Rapidly progressive glomerulonephrities (vasculitis): 2%• Renal Vascular Disease (i.e., renal artery stenosis)• Medications• Analgesic Nephropathy (progression after many years)• Pregnancy: high incidence of increased creatitine and HTN
during pregnancy associated with CRF
Stages of Chronic Renal Failure
1. Silent – GFR up to 50 ml/min.2. Renal insufficiency – GFR 25 to 50 ml/min.3. Renal failure – GFR 5 to 25 ml/min4. End-stage renal failure – GFR less than 5
ml/min.
Diabetic Nephropathy
• What can be done to reduce the risk of problems?– Blood glucose control– Blood pressure control– Using ACE inhibitors and AT II antagonists– Diet– Controlling blood lipids and cholesterol– Smoking
Treatment for Diabetic NephropathyStageStage AssessmentAssessment TreatmentTreatment
No ProteinuriaNo Proteinuria Monitor BP & GlucoseMonitor BP & Glucose
Screen for Screen for micoalbumininuriamicoalbumininuria
Hypertension drugs if Hypertension drugs if needed (BP should be needed (BP should be 130/85 or lower). Dietary 130/85 or lower). Dietary advice for sugar and fat, advice for sugar and fat, stop smokingstop smoking
MicroalbuminuriaMicroalbuminuria Close monitoring of BP, Close monitoring of BP, Glucose and blood lipids, Glucose and blood lipids, monitor urinary proteins monitor urinary proteins & CCr& CCr
Add more Hypertension Add more Hypertension drugs if needed needed. drugs if needed needed. Monitor cholesterol and Monitor cholesterol and add ACE inhibitor if add ACE inhibitor if neededneeded
ProteinuriaProteinuria Close monitoring of BP, Close monitoring of BP, glucose and blood lipids, glucose and blood lipids, monitor urinary protein monitor urinary protein and 24 CCrand 24 CCr
BP should be lower than BP should be lower than 125/75, low protein diet125/75, low protein diet
Declining kidney functionDeclining kidney function Prepare for dialysis &/or Prepare for dialysis &/or transplanttransplant
Metabolic changes
• Na+ excretion initially increased• Edema occurs when GFR continues to diminish.• NH4+ excretion declines adding to metabolic
acidosis.• Bone CaCO3 begins to act as a buffer for the acidosis
and leading to chronic bone loss and bone lesions develop (renal osteodystrophy).
• Accumulations of normally secreted uremic toxins
Uremic Syndrome
• Uremia occurs in stage 3 & 4 of CRF. It means literally “urine in the blood”– Symptomatic azotemia– Fever, Malaise– Anorexia, Nausea– Mild neural dysfunction– Uremic pruritus (itching)
Associated problems with CFR• Immunosuppression
– Increased risk of infection– People with CFR should be vaccinated regularly
• Anemia– Due to reduced erythropoietin production by kidney. Usually doesn’t
occur until 6-12 mos prior to dialysis• Hyperuricemia (Gout)
– Increased uric acid in system– Pain in joints, may contribute to renal dysfunction
• Hyperphosphatemia– Increased parathyroid hormone levels– Increased phosphate load from bone metabolism
• Hypertension• Poor coagulation• Proteinuria
Chronic Renal Failure• Chronic Renal Failure and Its
Progression
• Functional Adaptation to Nephron Loss– Increased amount of sodium
that escapes reabsorption– Excessive amount of potassium
Treatment of Chronic Renal Failure• Metabolic Acidosis• Anemia• Renal Osteodystrophy• Uremic Neuropathy• Sexual Dysfunction• Hypertension
Conservative Treatment
Dialysis Transplant
Hemodialysis Peritoneal Related Donor Cadaver Donor
Home Center
Treatment of End Stage Renal Failure
• Hemodialysis– Uses a mechanized
filter to remove impurities from the blood system
– Essentially replaces kidney with a machine
– Dialysis usually occurs a couple times per week.
Treatment of End Stage Renal Failure
• Peritoneal Dialysis– Uses the
abdominal cavity as a filter
Treatment of End Stage Renal Disease
• Survival of People with ESRD– Data show a mean expected remaining life span of
just under 8 years for people 40-44 beginning dialysis and just over 4 years for people 60-64
• Adequacy of Dialysis
• Nutrition
Chronic Renal Failure• Physical Rehabilitation – benefits of exercise• Vocational Rehabilitation– The goal should be to help the person with chronic renal
failure to resume all the duties, responsibilities and benefits he or she enjoyed prior to the illness
– Gainful employment is extremely important for an adult in the earning period of his or her life, to regain self-esteem and to interact with society confidently• Fear of losing financial benefits may deter some people • Some research has shown that multidisciplinary
predialysis intervention leads to maintenance of job