PCV2 vaccine cross- protection: Identification of sequences in successfully vaccinated field cases Brian Payne 1 , DVM; Amy Jacobs 2 , BS; Cheryl Dvorak 3 , PhD; Michael Murtaugh 3 , PhD 1 Boehringer Ingelheim Vetmedica, Inc. (BIVI), St. Joseph, Missouri 2 Field Research Services, Boehringer Ingelheim Vetmedica, Inc., Ames, Iowa 3 Department of Veterinary and Biomedical Sciences, U. of MN, St. Paul, Minnesota
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Dr. Brian Payne - PCV2 Vaccine Cross-Protection: Identification of Sequences in Successfully Vaccinated Field Cases
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PCV2 vaccine cross-protection: Identification of sequences in successfully vaccinated field casesBrian Payne1, DVM; Amy Jacobs2, BS; Cheryl Dvorak3, PhD; Michael Murtaugh3, PhD1Boehringer Ingelheim Vetmedica, Inc. (BIVI), St. Joseph, Missouri 2Field Research Services, Boehringer Ingelheim Vetmedica, Inc., Ames, Iowa3 Department of Veterinary and Biomedical Sciences, U. of MN, St. Paul, Minnesota
Summary• Mutations in PCV2 do occur• Evolution of the virus is inevitable
• CircoFLEX® continues to protect• On-going monitoring is
recommended• Root cause analysis needed
Yes, mutants exist• Commercial PCV2
vaccines are based on PCV2a
• PCV2b became dominant strain when PCV2 vaccines were launched
• PCV2d has emerged and is becoming predominant strain
Takahagi, Differential Effects of Porcine Circovirus Type 2 (PCV2) Vaccination on PCV2 Genotypes at Japanese Pig Farms, Virology, 2009, 35-41.
PCV2 compilation, NAHMS 2012• More mixing of A and
B compared to 2006• 82% had PCV2b• 48% had PCV2a• 35% mixed infections