Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1

1 Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1 Qi Yin, 1,2,9 Hongye Wang, 1,9 , Zhenfei Xie, 1,2,9 Lifang Jin, 1,3,9 Yifu Ding, 1,2,9 Na Li 1,4,9 ,Yan Li, 1 Qiong Wang, 1 Xinyi Liu, 5 Liuqing Xu, 5 Kai Wang, 1 Yanbo Cheng 1 , Boran Chang 1 , Cuiqing Zhong, 1 Qian Yu, 6 Wei Tang, 6 Wanjin Chen, 5 Wenjun Yang, 1 Fan Zhang, 7 Chen Ding, 7 , Lan 5 Bao, 1 Bin Zhou, 1 Ping Hu 1,* and Jinsong Li 1,2,8,* 1 State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China. 10 2 Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China. 3 College of Life Science of Shaoxing University, Shaoxing Zhejiang 312000, China. 4 Shanghai University of Medicine & Health Sciences, Shanghai 201318, China 15 5 Department of Neurology and Institute of Neurology, First Affiliated Hospital, Fujian Medical University, 20 Chazhong Road, Fuzhou 35005, China. 6 Animal Core Facility, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China. 20 7 State Key Laboratory of Genetic Engineering, Human Phenome Institute, Institutes of Biomedical Sciences, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. 8 School of Life Science and Technology, Shanghai Tech University, 100 Haike Road, Shanghai 201210, China. 25 9 These authors contributed equally to this work. *Correspondence to: J.L. ([email protected]) or P.H. ([email protected]). certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprint (which was not this version posted June 3, 2019. ; https://doi.org/10.1101/658526 doi: bioRxiv preprint

Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1

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