26/07/2021 rcog (iPosterSessions - an aMuze! Interactive system) https://rcog2021.ipostersessions.com/Default.aspx?s=57-B8-AB-2B-93-48-4E-C9-F1-F2-68-D1-A4-A0-DD-2E&pdfprint=true&guestview=true 1/8 Placental histology and umbilical artery doppler in pregnant women with severe COVID- 19 V Vannevel (1,2,3), C Wright (4,5), T Hlongwane (1,2,3), U Feucht (1,2,6), P Soma-Pillay (1,2,3), S Adam (3), D Fosu-Amoah (1,2), H Van Deventer (5), M Venter (7), A Mendes (7), M Coetzee (6), J Cloete (6), C Chasela (8,9), R Pattinson (1,2,3) (1) Research Centre for Maternal, Fetal, Newborn & Child Health, University of Pretoria (2) SAMRC Maternal and Infant Health Care Strategies Unit, Pretoria, South Africa (3) Dept of Obstetrics and Gynaecology, University of Pretoria (4) Division of Anatomical Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (5) Lancet Laboratories, Johannesburg, South Africa (6) Dept of Paediatrics, University of Pretoria (7) Zoonotic Arbo and Respiratory virus research group, Centre for Viral Zoonosis, Dept of Medical Virology, University of Pretoria (8) Right To Care, Centurion, South Africa (9) Dept of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa PRESENTED AT:
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26/07/2021 rcog (iPosterSessions - an aMuze! Interactive system)
Placental histology and umbilical arterydoppler in pregnant women with severe COVID-
19
V Vannevel (1,2,3), C Wright (4,5), T Hlongwane (1,2,3), U Feucht (1,2,6), P Soma-Pillay(1,2,3), S Adam (3), D Fosu-Amoah (1,2), H Van Deventer (5), M Venter (7), A Mendes
(7), M Coetzee (6), J Cloete (6), C Chasela (8,9), R Pattinson (1,2,3)
(1) Research Centre for Maternal, Fetal, Newborn & Child Health, University of Pretoria (2) SAMRCMaternal and Infant Health Care Strategies Unit, Pretoria, South Africa (3) Dept of Obstetrics and
Gynaecology, University of Pretoria (4) Division of Anatomical Pathology, Faculty of Health Sciences,University of the Witwatersrand, Johannesburg, South Africa (5) Lancet Laboratories, Johannesburg, South
Africa (6) Dept of Paediatrics, University of Pretoria (7) Zoonotic Arbo and Respiratory virus researchgroup, Centre for Viral Zoonosis, Dept of Medical Virology, University of Pretoria (8) Right To Care,
Centurion, South Africa (9) Dept of Epidemiology and Biostatistics, School of Public Health, Faculty ofHealth Sciences, University of the Witwatersrand, Johannesburg, South Africa
PRESENTED AT:
26/07/2021 rcog (iPosterSessions - an aMuze! Interactive system)
BACKGROUNDCOVID-19 is known to in-part be a vascular disease.
SARS-CoV-2 has been shown to affect the placenta, and varied histological pictures have been described.
Vascular placental disease leads to reduced placental blood flow, and increases the resistance of blood flow inthe placenta. This can be detected by increased resistance indices measured by doppler ultrasound.
Study aim: To investigate associations between severe COVID-19 disease in pregnancy, abnormalities in thedoppler ultrasound of the fetal umbilical artery (UA), and placental histology.
26/07/2021 rcog (iPosterSessions - an aMuze! Interactive system)
3 likely due to SARS-CoV-2 (no other risk factors)
Other 3 possibly related to SARS-CoV-2, but also umbilical cord abnormalities
One woman was admitted with COVID-19 at 31 weeks' gestation, developed an abnormal UA doppler duringfurther antenatal follow-up and delivered a healthy neonate at term. Her placenta showed both MVM (withouthypertension) and FVM (without cord abnormalities).
Study results may indicate need to screen pregnant women with COVID-19 with doppler ultrasound
Study still ongoing to increase sample size
26/07/2021 rcog (iPosterSessions - an aMuze! Interactive system)
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