docs-2fEffects+of+homeopathy+in+weight+loss.ppt

Effects of homeopathy in reducing weight, body fat mass and percent body fat. A randomized, double-blind, placebo controlled clinical trialDr. Linda KimDr. Pam SwanDr. Robert WatersMichael SmithJennifer Orlowski

What is homeopathy?Like Cures LikeLaw of MinimumsStimulate bodys own healing processIe. Ipecac

Effectiveness of HomeopathyA meta-analysis of placebo controlled clinical trials demonstrated that homeopathic effects are not due to placebo alone, there was a 2.45 times greater effect than placeboMeta-analysis of 107 controlled trials showed 76% of those studies were effective

Obesity in AdultsEstimated 97 million adults in US are overweight or obeseOverweight defined as BMI of 25 to 29.9 kg/m and obesity is a BMI of greater than or equal to 30 kg/m

Risk of ObesityHypertensionDyslipidemiaType 2 Diabetes Coronary heart diseaseStrokeGallbladder diseaseOsteoarthritisSleep apneaRespiratory problemsEndometrial, breast, prostate, or colon cancer

What were the questions we asked?Does homeopathy promote more weight loss than placebo?What is the short term efficacy of a homeopathic weight loss product?

What did the treatment address?Reducing food cravingsRespond to normal satietyImproving metabolismControlling hypoglycemiaMental/emotional issuesexercise

The product we used in the studyWeight Control manufactured by Dolisos America Inc.

Homeopathics IncludedAnacardium orientaleAntimonium crudumCalcarea carbonicaGraphitesIodiumNuv Vomica

Remedies and their roles in weight loss

SxAnacardiumAntimoniumCalceraGraphitesIodiumNuxvomicaCurbing HungerXXXXXXImproving metabolismXXXHypo - glycemiaXXOver - eatingXXmoodXXCravingsugarXCravingFatXX

MethodsRecruited people from Phoenix metropolitan areaInitial screening was done by phone using inclusion/exclusion criteriaQualified 35 patient, 30 completed

MethodsInclusion:Male/female 21-45 y.oBMI 30-39 kg/mConfirmed menstrual period prior to enrollmentAble to comply with study requirements: informed consent, 2 office visits, follow up monitoring, avoid other diet programs and perform exercise program

MethodsExclusion:Pregnant, lactating, or wanting to become pregnantObesity of endocrine originHistory of bulimia or anorexiaHistory of alcohol or drug addiction

Methods 4 week trialTake 1 tablet 4 times per day sublingualExercise 4 times per weekWear pedometer dailyFill out daily questionersWeekly phone monitoringOffice visit 2 times

Methods: Office visitPhysical exam:BP, pulse, respiration rate, temperatureWeight, height, body measurements hip and waistMetabolic testing with a Bod Pod {ADD HERE}

Outcome ParametersBody weight changesBMI, lean body mass, fat mass, percent body fatBody change measurementsCircumference of waist and hipHip/waist ratioMetabolic testingRespiratory exchange rateQuestionairesVAS of hunger, satiety, thirst, mood [daily]Pedometer logQuality of Life Index SF-36, defecation pattern, satisfaction w/ intervention, compliance [2 times]Hamilton Depression scale [2 times]

ResultsOf the 35 people enrolled 30 completed the study, giving a 14% drop out rateScreened 126 patients with 230 inquires

Body Measurement changesThese were not significant between the active group and the placebo group. There weight decreases and body measurement changes in active group from baseline to end of treatmentThis suggest a pattern of weight reduction, but not a conclusive difference

Exercise ComplianceThere was a significant change (p < .05) noted with exercise compliance between active and placeboPatients in active group recorded more exercise on average than placebo

QuestionairesThese were significant (P < .05) The daily questionaire asking about hunger, satiety, thirst, mood and defecation should overall improvement in active group as compared to placeboResults from SF 36 confirmed resultsImprovements may have been attributed to increase incidence of exercise in active group

Depressive ScaleNo conclusive change in scale and patient compliance between placebo and active group

Adverse EffectsNone were reportedThe only complaint reported by some patient was amount of time required to dissolve pill

ConclusionIt was not conclusively shown that this product promoted weight loss, however the time interval may have been to short to draw a significant conclusionIt was conclusively shown that the active group did notice changes in quality of life issues, suggesting that the product may be effective at a longer interval

Future StudiesWe should do a 3 month study to determine if weight loss would be significant at a longer time interval.

Statistical AnalysisEach body measurements were analyzed using a mean, standard deviation, t test and Wilcoxons signed rank test. Confidence intervals of 95% were utilized to detect statistical significance