Do Titanium Particles Cause Bone Loss Around Dental Implants? WANG et al. (2019) | DOI: 10.1111/JRE.12633 MACROPHAGE POLARIZATION IN ASEPTIC BONE RESORPTION AROUND DENTAL IMPLANTS INDUCED BY TI PARTICLES IN A MURINE MODEL Bone loss around dental implants leads to implant failure Is bone loss triggered by leakage of titanium (Ti) particles from the implant, and if so, what is the mechanism? Bone loss Ti particles + clodronate Ti particles + empty liposomes Ti particles + PBS PBS control Ti implanted in Sprague Dawley rats Analysis of implants Ti increases inflammatory M1 macrophages, pro-inflammatory cytokines, and bone loss Inflammatory cytokines and bone loss induced by Ti particles were reduced upon depletion of macrophages by clodronate Ti Ti Ti TNF-α TNF-α TNF-α TNF-α RANKL RANKL IL-1β IL-1β IL-1β IL6 IL6 IL6 IL6 IL6 Ti Ti Ti Ti Ti Clodronate Titanium particles from dental implants activate macrophages that cause inflammatory reactions resulting in bone loss and implant failure
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Do Titanium Particles Cause Bone Loss Around Dental Implants?
WANG et al. (2019) | DOI: 10.1111/JRE.12633
MACROPHAGE POLARIZATION IN ASEPTIC BONE RESORPTION AROUND DENTAL IMPLANTS INDUCED BY TI PARTICLES IN A MURINE MODEL
Bone loss around dental implants leads to implant failure
Is bone loss triggered by leakage of titanium (Ti) particles from the implant, and if so, what is the mechanism?
Bone loss
Ti particles + clodronate
Ti particles + empty liposomes
Ti particles + PBS
PBS control
Ti implanted in Sprague Dawley rats
Analysis of implants
Ti increases inflammatory M1 macrophages, pro-inflammatory cytokines, and bone loss
Inflammatory cytokines and bone loss induced by Ti particles were reduced upon depletion of macrophages by clodronate
Ti
Ti
Ti
TNF-α
TNF-α
TNF-α
TNF-α
RANKL
RANKL
IL-1β
IL-1βIL-1β
IL6
IL6IL6
IL6
IL6
Ti
Ti
Ti
Ti
Ti
Clodronate
Titanium particles from dental implants
activate macrophages that cause inflammatory
reactions resulting in bone loss and implant
failure
Ti increases inflammatory M1 macrophages, pro-inflammatory cytokines, and bone loss
Inflammatory cytokines and bone loss induced by Ti particles were reduced upon depletion of
macrophages by clodronate
Ti
Ti
Ti
TNF-α
TNF-α
TNF-α
TNF-α
RANKL
RANKL
IL-1β
IL-1βIL-1β
IL6
IL6IL6
IL6
IL6
Ti
Ti
Ti
Ti
Ti
Clodronate
Do Titanium Particles Cause Bone Loss Around Dental Implants?
Bone loss
Titanium particles from dental implants activate macrophages that cause
inflammatory reactions resulting in bone loss and
implant failure
WANG et al. (2019) | DOI: 10.1111/JRE.12633
MACROPHAGE POLARIZATION IN ASEPTIC BONE RESORPTION AROUND DENTAL IMPLANTS INDUCED BY TI PARTICLES IN A MURINE MODEL
Ti particles + clodronate
Ti particles + empty liposomes
Ti particles + PBS
PBS control
Ti implanted in Sprague Dawley rats
Analysis of implants
Bone loss around dental implants leads to implant failure
Is bone loss triggered by leakage of titanium (Ti) particles from the implant, and if so, what is the mechanism?
Ti increases number of inflammatory macrophages
Clodronate reduces production of inflammatory cytokines in bone caused by Ti
Ti
Ti
Ti
TNF-α
TNF-α
TNF-α
TNF-α
RANKL
RANKL
IL-1β
IL-1βIL-1β
IL6
IL6IL6
IL6
IL6
Ti
Ti
Ti
Ti
Ti
Clodronate
Do Titanium Particles Cause Bone Loss Around Dental Implants?
Bone loss
Ti particles + clodronate
Ti particles + empty liposomes
Ti particles + PBS
PBS controlTi implanted in
Sprague Dawley rats Analysis ofimplants
Bone loss around dental implants leads to implant failure
Is bone loss triggered by leakage of titanium (Ti) particles from the implant,
and if so, what is the mechanism?
Titanium particles from dental implants
activate macrophages that
cause inflammatory reactions resulting in
bone loss and implant failure
WANG et al. (2019) | DOI: 10.1111/JRE.12633
MACROPHAGE POLARIZATION IN ASEPTIC BONE RESORPTION AROUND DENTAL IMPLANTS INDUCED BY TI PARTICLES IN A MURINE MODEL