DNA –Not Your Destiny! · 2019. 7. 17. · 2013-05-05 3 1800, 1812, 1821, 1836 and 1856 were years of total crop failure and extreme suffering & 1801, 1822, 1828, 1844 and 1863

2013-05-05

1

Ge kroppen föda och själen näring!Del 2

Hur äter Du människa – Vad tycker Dina celler och

skyddsbakterier?

Stig Bengmark MD PhD, UCL, London University, UK

[email protected]

www.bengmark.com

Arrangemang av Pingstkyrkan & Radio Falköping i samarbete

med Hälsofrämjandet

DNA – Not Your Destiny!Anand P et al Pharm Res 2008;25:2097-2116

Stressors like a calorie-rich diet turn genes on and off, activate epigenetic markers,

modify histones, & seem to affect what gets passed down to the offspring

DESCRETE PERSISTANT INFLAMMATION

- A MOTHER OF DISEASE

Bengmark S. J Clin Nutr 2004;23:1256-1266

Increase of ChDs 1850 – 2005 parallel to:100 % increase in consumption of saturated fats

2500 % production of milk/cow (2 l/d => 50 l/d )

10000 % increase in refined sugar intake (1 lb => 100 lb)

DESTABILIZING FACTORSExcess of refined processed foods: dys-functioning proteins (AGEs & ALEs), fats, sugars, hormones & chemicals; pharma, environmental toxins etc.

increases pro-oxidant actions, stimulates over-expression of inflammatory messengers, reduces flora, increases membrane leakages, destabilizes the immune system

Contributory are:

Lack of physical activity

Mental and physical stress

Vitamin D deficiencydecreases resistance to disease

MAJOR HEALTH THREATS

& life expectancy

Stress ? years

Low physical activity ? years

Obesity ? years

Alcohol abuse 4 - 5 years

Tobacco abuse 8 - 12 years

Food abuse 20 - 25 years

2013-05-05

2

FOOD INTAKE & INFLAMMATION • 1. Low intake of fresh plant foods;

GREENS, vegetables, fruits, spices. Higher intake of proteotoxins in certain foods: casein, gluten, zein (corn) etc.

• 3. Higher intake of heat- and storage-inducedproteotoxins: glycated (AGEs), lipoxidatedmolecules (ALEs),processed carbohydratesinduces: - Dysbiosis: reduced numbers & diversity- Various body membranes leak like a sieve; leaky gut, leaky airways, leaky skin, leaky vagina, leaky eye cavity , leaky nose, leaky placenta, leaky blood-brain barrier etc.

Dennis Burkitt 1911 - 1993Suggested that many

Western diseases, rare in

Africa are primarily the

result of diet and lifestyle.

Reported an association

between low fibre in diet

higher risk of colorectal

cancer and other chronic

diseases such as

CHV and diabetes

GI PERISTALSIS – UK vs UGANDA

Appr GI transit time:

UK: 100 hrs vs Uganda: 20 hours

Appr stool weight:

UK 60 g/day vs Uganda 600 g/day Burkitt DP et al Lancet 1972;300 (7792):1408-11

British geriatric patients:

GI transit time: >14 days

in > half of the patientsBrocklehurst JC, Khan MY. Gerontol Clin 1969;11:293-300

FERMENT YOUR VEGETABLES

2013-05-05

3

1800, 1812, 1821,

1836 and 1856 were

years of total crop

failure and extreme

suffering & 1801,

1822, 1828, 1844

and 1863 were

years with food in

abundance.

Bygren LO et al Acta

Biotheor 2001

;49:53-59

MOTHER´S EATING– EFFECTS ON OFFSPRINGCanini RB et al Nutr Res Rev 2011 E-pub

NONBREAST-FEEDING & UNHEALTH

Non-breastfeeders: - have an increased chance of becoming over-weightChapman DJ J Hum Lact 2009;25:242–243

- suffer an increased risk of breast-cancer later in lifeStuebe AM et al Arch Intern Med 2009;169:1364–1371

- are less stress-resistent Mezzacappa ES et al. J Psycho Res 2005;58:351–365

- are more prone to get depression after deliveryGallup Jr GG et al Med Hypotheses 2010;74:174–176

- may contribute to autism in the next childGallup GC et al Medical Hypotheses 77 2011;77:345–346

Daily Mail 2011 Dec 22 - Commentary to IGF-1 & Breastfeeding

Madsen AL et al Growth Horm IGF Res 2011;21:199-204

2013-05-05

4

Maccaferri S et al Dig Dis 2011;29:525–530

LEAKY BARRIERS

• Gastrointestinal tract

• Airways

• Skin

• Oral cavity

• Vagina

• Nose

• Eye cavity

• Placenta

• Blood brain barriers

METABOLIC SYNDROME – DYSBIOSISTremellen K, Pearce K Med Hypotheses 2012;79:104-112

DIFFERENT MICROBIOTA IN OBESE vs LEANAngelakis E et al Future Microbiol. 2012;7: 91–109

GUT MICROBIOTA & METABOLISMVrieze A et al Diabetologia 2010;53:606-613

↓ FaMy acid oxidaNon

↑ LPS (endotoxin) – inflammation

↓ Buturate secreNon

↑ FaMy acid oxidaNon

↓ LPS – inflammation

↑ Buturate secreNon

MICROBIONTA, ENDOTOXIN & OBESITY

Muccioli GG et al Mol Syst Biol 2010;6:392

Obesity is characterised by altered gut

microbiota & low-grade inflammation

ENDOTOXIN (LPS) acts as a master switch

to control adipose tissue metabolism

Gut microbiota regulates

plasma lipopolysaccharide (LPS) levels,

gut permeability & adipogenesis

2013-05-05

5

OBESITY – A METABOLIC DISORDERCani PD, Delzenne NM Curr Pharm Des. 2009;15:1546-1558

OBESITY – A METABOLIC DISORDERCani PD, Delzenne NM Curr Pharm Des. 2009;15:1546-1558

OBESITY – A METABOLIC DISORDERCani PD, Delzenne NM Curr Pharm Des. 2009;15:1546-1558

INFLAMMATION IN OBESE PREGNANT WOMEN

Basu S et al Obesity 2011;19:476-482

PALEOLITHIC DIET“Much support that our genes, adapted during million of

years to the lifestyle of our prehistoric ancestors badly

tolerate the dramatic changes, especially in food habits,

which have occurred”.

Eaton BS, Konner M. Paleotlithic nutrition: a consideration of its nature and current implications. N Engl J Med 1985;312:283-289

Contained more of: (X = times more)

Minerals 2 X

Fibers/greens 4 to 10 X

Antioxidants 10 X

Omega-3 FA 50 X

Lactic acid bacteria >1010 X

Contained less of:(X = times less)

Protein 2 X

Saturated FA 4 X

Sodium 10 X

Proc carbohydrates >1000 X

LIFESTYLE & CHOLESTEROL/S

Mg/dL mM/L

Westerners <200 <5.18

Rural Chinese 127+15 3.3+0.4

Hunters-gatherers 123+7 3.2+2.2

Other Primates 90-135 2.3-3.5

2013-05-05

6

Homo erectus2 milj – 100 000 years bC

”diet consisted of

leaves, wild grasses,

nuts, berries, flowers,

less often tubers, roots,

honey, occasional red

meat, shellfish and

bird's eggs.”

OMEGA-3/OMEGA-6 RATIO Simopoulos AP Mol Neurobiol 2011;44:203-215

FOREFATHER´S CHOICES

1. To store foods in the soil

2. To use heat for production and

preparation of foods

3. To cultivate grains for food

4. To domesticate animals

RECENT GENERATIONS ADDED

MANIPULATIONS:• PLANT BREEDING

• ANIMAL BREEDING

• MODERN AGRICULTURE• FOOD PROCESSING: separation, condensation, drying , freezing, irradiation, burning, roasting, curing, microvawing, emulsifying, toasting , supplementing salt etc

• BAKING

• COOKING

• FRYING

• GRILLING

• etc.

HEATING EFFECTS:

� app 28 C antioxidants start to disappear> app 41 C food enzymesinactivated

� > 80 C addition ofglycated and lipoxidatedmolecules called AGEs & ALEs

� > app 130 C addition ofheterocyclic amines

VITAMIN D DEFICIENCY COMMON IN PATIENTS

Burkina Faso:

115nmol/L

(> 70 nmol/L)

Luxwolda MF

et al. Brit J Nutr

2012; E-pub

• 95% of Afro-Americans undergoing renal transplantation Tripathy SS et al Transplantation 2008;85: 767–770

• 85 % of patients undergoing hip or kneereplacement

• Breijawi N et al Eur Surg Res 2009;42:1–10

• 77 % of chronic pancreatitis patients Dujsikova H et al Pancreatology 2008;8:583–586

• 67 % of renal transplantation patients Ducloux D et al Transplantation 2008;85: 1755–1759

• 57 % obesity surgery patients (79 % in black and Hispanic) Gemmel K et al Surg Obes Rel Dis 2009,5, 54–59

Vitamin D deficiencies (< 30 mol/L)

In Westerners undergoing surgery:

2013-05-05

7

VITAMIN D DEFICIENCY & DISEASE• Aging

• Allergy

• Alzheimer’s disease

• Asthma

• Athletic performance

• Autism

• Cancer

• Cavities

• Colds

• Crohn´s disease

• Cystic fibrosis

• Depression

• Diabetes 1 and 2

• Eczema

• Heart disease

• Hearing loss

• Hypertension

• Infertility

• Influenza

• Insomnia

• Liver diseases

• Macular

degeneration

• Migraines

• Multiple Sclerosis

• Muscle pain

• Obesity

• Periodontal disease

• Pre-eclampsia

• Psoriasis

• Rheumatoid

diseases

Schizophrenia

• Seizures

• Septicemia

• Tuberculosis

MICROBIOTA, AFRICAN & EUROPEANDe Filippo C et al Proc Natl Acad Sci USA 2010; 107:14691–14696

MICROBIOTA, AFRICAN & EUROPEANDe Filippo C et al Proc Natl Acad Sci USA 2010; 107:14691–14696

MICROBIOTA, AFRICAN & EUROPEANDe Filippo C et al Proc Natl Acad Sci USA 2010; 107:14691–14696

Maccaferri S et al Dig Dis 2011;29:525–530

LEAKY BARRIERS

• Gastrointestinal tract

• Airways

• Skin

• Oral cavity

• Vagina

• Nose

• Eye cavity

• Placenta

• Blood brain barriersBoutenko V.

Green for Life. North Atlantic Books

Calif, USA, 2010

2013-05-05

8

80/10/10 DIET80 % raw greens

10 % vegetable fats

10 % vegetable proteins

DIET & LONGEVITYRobbins J: Health at 100. USA 2007

HYPOTHESIS: NUTRITION-INDUCED METABOLIC DISORDERS

Cani PD et al Diabetes 2008;57:1470-1481

LPS concentration 10 to 50 X higher

than those obtained during septic

shockMitaka C. Clin Chim Acta 2005; 351(1-2):17-29

Bifidobacterim

spp.

ENDOTOXIN & PROSPECT OF LIFEPussinen PJ et al. Diabetes Care 2011; 34:392–397

2013-05-05

9

ENDOTOXIN-ASSOCIATED DISEASES• Alzheimer Jaeger LB et al. Brain

Behav Immun. 2009 May ; 23(4): 507–

517

• Cognitive impairment Lee JW

et al. J Neuroinflammation 2008; 5: 37

• Arterio-/Coronary Diseases Heo SK et al Immunol Lett 2008;120:57-

64

• Diabetes type 1 Nymark M et al

Diabetes Care 2009 32(9): 1689–1693

• Diabetes type 2 Andreasen AS

Intensive Care Med. 2010;36:1548-1555

• Cancer Hsu RY et al Cancer Res.

2011;71(5):1989-1898

• ADHD, allergy, ALS, autism, autoimmune diseases, bipolardisease, cataracts, chronicfatigue syndrome, COPD, minimal encephalopathy, fibromyalgia, glaucoma, gulf war syndrome, HIV, iritis, liver cirrhosis, maculardegeneration, multiplesclerosis, nephropathies, obesity, osteoporosis, paradontosis, Parkinson, polycystic ovary syndrome, rheumatoid disease, schizophrenia, stress, stroke, uveitis

ENERGY INTAKE & ENDOTOXIN/plasma Amar J et al Am J Clin Nutr. 2008;87:1219-1223

A FAT-RICH MEAL & INFLAMMATION Erridge E et al Am J Clin Nutr 2007;86:1286-1292

• Increases circulating leukocytes (neutrophils, lymphocytes, and platelets)

• Activates of the transcription factor nuclear transcription factor B (NF-B) in peripheral blood mononuclear cells

• Increases expression of tumor necrosis factor-(TNF-) in monocytes

• Alters some surface adhesion molecules in neutrophils and monocytes

• Activates Toll-like receptor 4 (TLR4) complex &

• Activates platelets and coagulation

ANIMAL FAT INTAKE – PANCREATIC CANCEROtsuko M, Tashiro M Intern Med 2007;46:109-113

FOOD & RISK OF PANCREATIC CANCERChan JM et al Cancer Causes Control 2007;18:1153-1167

• total dairy 2.6

• butter 2.4

• beef/lamb 2.2

• hamburgers 1.7

• egg 1.7

• chicken 0.7

• Highfat/processed-

meat products:

sausage, salami,

bacon especially

associated with risk:

• animal fat 1,9

• saturated fat 1.9

• total fat 1.6

• cholesterol 1.5

• monounsaturated fat 1.3

PROCESSED FOODS INDUCE DYSBIOSIS - Animal products (espec. dairy), rich in IGF-1

- Refined carbohydrates promotes IGF-1 synthesis in

the liver

• Increase expression of inflammatory messengers

• Induce dysbiosis

• Increase expression of inflammatory messengers

• Increase membrane leakages &

• Destabilize the immune system

Contributory are: Mental & physical stress, lack of physical

activity,, vitamin D deficiency, lack of anti-inflammatory

minerals; Mg, Zn, Se, lack of omega-3 FFAs etc.

2013-05-05

10

HIGH FAT MEAL – ENDOTOXIN/sHarte AL et al Diabetes Care 2012;35:375-382

Non-obese controls (NOC) (n = 9), obese subjects (n = 15), impaired glucose tolerance (IGT) (n = 12), type 2 diabetes (n = 18).

HIGH FAT DIET & MICROBIAL TRANSLOCATIONAmar J et al EMBO Mol Med 2011;13:559-572

Live intestinal bacteria found present in large numbers in

adipose tissue (MAT), mesenteric lymph nodes (MLN) and

blood AFTER ONLY ONE WEEK ON HIGH FAT DIET (HFD)

INTAKE OF FOOD & INFLAMMATIONErridge C Brit J Nutr 2011;105:15-23

MEAT STORAGE – INFLAMMATION INDUCTIONErridge C J Food Sci 2011,76,72-79

VEGETABLE STORAGE – INFLAMMATION INDUCTIONErridge C Food and Chemical Toxicology 2011;49:1464–1467

HIGH FAT INTAKE, ENDOTOXIN/pl & LEAKY GUTCani PD et al Diabetes 2008;57:1470-1481

2013-05-05

11

ALMOST HALF OF

WESTERN BABIES BORN

BY CESAREAN SECTION

INFECTED DURING

THIRD SEMESTER OF

PREGNANCY

FETAL LIFE & IMPAIRED PROGRAMMING

Barker David JP, Southhampton:Curr Opin Nephrol Hypertens 1997; 6:106-110

“We have become accustomed to the idea that the major

disorders of adult life, including coronary heart disease,

stroke and diabetes, arise through interaction between

influences in our adult lifestyle and genetically determined

susceptibility. Recent research, however, suggest that

growth in utero may also play an important role.”

“Even brief periods of …………may permanently change or

`programme` the body…………………………………

and lead to persistent changes in blood pressure,

cholesterol metabolism, insulin response to glucose, and in

a range of other metabolic, endocrine and immune

parameters.” …… and chronic diseases later in life

LEAKY PLACENTAA shocking 9/20 (43 %) of umbilical cord blood, cultivated from healthy neonates born by cesarean section, demonstrated positive growth: Enterococcus faecium, Propionibacterium acnes, Staphylococcus epidermidis & Streptococcus sanguinisJiménez E et al. Curr Microbiol 2005;51:270–274.

ATHEROSCLEROSIS & BACTERIAL DEBRISNicolaou G et al J Atheroscler Thromb 2012;19:137-1498

Bacteria & bacterial debris

in human atheroma, in the

past considered harmless,

seems to

contribute to disease

progression via

TLR-dependent lipid body

formation in macrophages

CHRONIC DEPRESSION & LEAKY GUTMaes M J Affect Dis 2012 E-pub

CHRONIC DEPRESSION & LEAKY GUTMaes M J Affect Dis 2012 E-pub

2013-05-05

12

ENDOTOXIN & METABOLIC SYNDROMEPussinen PJ et al. Diabetes Care 2011; 34:392–397

ALZHEIMER, NEUROINFLAMMATION &

ENDOTOXIN (LPS)Piazza A, Lynch MA Biochem Soc Trans. 2009;37:303-307

FATTY ACIDS & INFLAMMATION(in vitro) Weatherill AR et al J Immunol 2005;174:5390-5397

• The saturated fatty acid, lauric acid, upregulates in dendritic cells and produce inflammation:

• Expression of costimulatory molecules (CD40, CD80, & CD86)

• MHC class II

• Cytokines (IL-12p70 and IL-6) &

• Increased T cell activation

• In contrast, the n-3 polyunsaturated fatty acid, docosahexaenoic acid inhibits inflammation:

• LPS-induced up-regulation of the co-stimulatory molecules

• MHC class II, and cytokine production

• LPS-induced T cell activation induced

PALMITATE-INDUCED INFLAMMATIONOberbach A et al PLoS One 2010; 28;5:e10882

Saturated free fatty acids (FFAs) especially palmitic acid (16:0),and

stearic acid (18:0) stimulate macrophage activation of NFκ-B &

expression of pro-inflammatory cytokines.

PALMITATE & ASTROCYTE INFLAMMATION(in vitro) Gupta S et al J Neurochem 2012;120 :1060-1071

HIGH FAT DIET & ALLERGYWoods LG et al J Allergy Clin Immunol 2011;127:1133-1140

2013-05-05

13

VEGAN DIET & HEALTHKatcher HI et al Ann Nutr Metab 2010;56:245–252

Employees ( insurance company) with overweight and/or diabetes received either a low-fat vegan diet or regular food for 22 weeks. The vegan group reported improvements in: ● general health (p = 0.002)

● physical functioning (p = 0.001)

●mental health (p = 0.03)

● general vitality (p = 0.004)

● overall diet satisfaction (p = 0.001)

● reduced food costs (p = 0.003), but

● increased difficulty finding foods when eating out

Bill Clinton Turns 65

– and Vegan!Friday Aug 18.2011

Once known for his love of barbecue and

impromptu stops at McDonald's, former

President Bill Clinton has radically changed

his diet, dropped weight and improved his health.

The former junk food lover now calls himself a vegan,

shunning meat, eggs, dairy and almost all oil."I like the vegetables, the fruits, the beans, the stuff I eat now," Clinton tells CNN.

After experiencing periodic heart problems leading up to the 2004 surgery,

Clinton has now lost 20 lbs. and says:

"I feel good, and I also have … more energy."

• pH 9.0 –watermelon,

asparagus, garlic, carrot

• pH app 8,5 - dates, figs,

apricots, mango, parsley,

lemon, lime, grape fruit,

algae, sea grass

• Green leaves – espec

organic: spinach, arugula,

broccoli, germs, nettles

• Fruits – espec organic:

avocado, pear, apple,

banana, berries, grapes,

peach

• pH app 8.0 - peas,

pumpkin, parsnip

• pH app 7.5 –green beans and

peas, pepper, red beat, broccoli,

various cabbages

• Fish – preferable wild

• Nuts, almonds & seeds – espec

organic: - pumpkin seeds, sesame

seeds, flaxseeds, sun flower

seeds etc

• Various beans and sprouts; chick

peas, black peas etc, buckwheat

• Spices- ginger, turmeric,

cinnamon, cardamom etc

• Himalaya mineral salt, carob,

• coconut

• Vegetable fats – flax oil, coconut

oil , canola oil, olive oil, avocado

oil etc.

DYSBIOSIS-INDUCED METABOLIC DISORDERS Cani PD et al Diabetes 2008;57:1470-1481

LPS concentration 10 to 50 X higher

than those obtained during septic

shockMitaka C. Clin Chim Acta 2005; 351(1-2):17-29

Bifidobacterim

spp.

ENDOTOXIN-THE VILLAIN? ASSOCIATED DISEASES:

Alzheimer Jaeger LB et al. Brain

Behav Immun. 2009; 23: 507–17

Cognitive impairment Lee JW et

al. J Neuroinflammation 2008; 5: 37

Arterio-/Coronary Diseases Heo SK et al Immunol Lett

2008;120:57-64

Diabetes type 1 Nymark M et al

Diabetes Care 2009 32(9): 1689–

1693

Diabetes type 2 Andreasen AS

Intensive Care Med. 2010;36:1548-

1555

Cancer Hsu RY et al Cancer Res.

2011;71(5):1989-1998

Chronic Liver diesases Nolan JP

Hepatology 2010;52:1829-1835.

•ADHD, allergy, ALS, autism,

autoimmune diseases, bipolar

disease, cataracts, chronic

fatigue syndrome, COPD,

fibromyalgia, glaucoma, gulf war

syndrome, HIV, iritis,

macular degeneration, minimal

encephalopathy, multiple

sclerosis, nephropathies,

obesity, osteoporosis,

paradontosis, Parkinson,

polycystic ovary syndrome,

rheumatoid disease, stress,

schizophrenia, stroke, uveitis

FLORA IN WESTERNERS• Lb plantarum, a dominating LAB,

in only 25 % of omnivorous Americans & in 65 % of vegetarian AmericansFinegold SM et al. Human intestinal microflora in health and disease Academic Press, London, UK, 1983. pp 3-31

• Common colonic LAB species present only in

• about 50 % or less of healthy Scandinavians:Lb plantarum 52 %, Lb rhamnosus 26 %,Lb paracasei ssp paracasei 17 %Ahrné S et al. J Appl Microbiol 1998;85:88-94

2013-05-05

14

MICROBIOTA & OBESITYMillion M et al. Int J Obesity 2012;36:817-825

Obese (n=68) Controls (n=44) P-value

L. plantarum 0 (0%) 8 (18.2%) 0.0004

L. paracasei 10 (14.7%) 17 (38.6%) 0.004

L. reuteri 6 (8.8%) 1 (2.3%) 0.16

L. rhamnosus 3 (4.4%) 4 (9.1%) 0.27

L. ruminis 3 (4.4%) 4 (9.1%) 0.27

L. salivarius 5 (7.4%) 2 (4.5%) 0.43

ENDOTOXIN

& OBESITYFei N, Zhao L. ISME J.

2012. Epub 13 dec

HUMAN GUT MICROBIONTA & OBESITYLey RE et al. Nature 2006; 444:1022-1023

12 obese individuals

Fat- & carbohydrate restricted diet for 52 weeks

The relative numbers of Bacteroidetes

increased & the numbers of Firmicutes

decreased significantly

Increased numbers of Bacteroidetes correlated

with percentage loss of body weight

ENDOTOXIN & OBESITYFei N, Zhao L. ISME J. 2012 Epub 13 dec 2012.

A person weighing 174.8 kg lost 51.4 kg after

23 weeks on traditional Chinese medicinal

foods, whole grains, & prebiotic fibres

recovered totally from hyperglycemia and

hypertension.

The endotoxin-producing Enterobacter cloacae

B29 - found to constitute 35% of the gut

bacteria - decreased to non-detectable.

The Enterobacter cloacae inoculated in germfree

mice induces obesity and insulin resistance.

ELEMENTAL COMPOSITION OF THE BODYElement Percent by mass Atomic percent (calc.)

Oxygen 65% 25.6%

Carbon 18% 9.5%

Hydrogen 10% 63%

Nitrogen 3% 1.3%

Calcium 1.5% 0.24%

Phosphorus 1.2% 0.24%

Potassium 0.2% 0.03%

Sulfur 0.2% 0.04%

Chlorine 0.2% 0.04%

Sodium 0.1% 0.03%

Magnesium 0.05% 0.01%

Iron 3 g in men, 2.3 g in women

Cobolt, Copper,

Zinc, Iodine< 0.05% each

Selenium, Flour < 0.01% each

MG-DEFICIENCY & METABOLIC DISORDERSMagnesium (Mg), an essential mineral, required

for cellular energy-dependent reactions involving

ATP and the regulation of calcium channel

function.

Subclinical hypomagnesemia

- increases the severity of the systemic

inflammatory response

- worsens the systemic response to endotoxins,

- increases endotoxemia, insulin resistance,

- promotes organ injuries, commonly seen in

critically ill and in various chronic diseases

2013-05-05

15

MAGNESIUM/s & MORTALITY Reffelmann T et al. Atherosclerosis 2011;219:280-284

Mortality in subjects with Mg++ ≤ 0.73 mmol/l was in comparison to

higher Mg++ concentrations significantly higher for all-cause deaths:

10.95 death vs 1.45 deaths (7x) & for cardiovascular deaths: 3.44

deaths vs. 1.53 deaths (2.4x) per 1000 person years.

MAGNESIUM – A KEY MOLECULE IN CELL REPLICATION

Mg involved in > 300 biochemical processes

Mg deficiency associated with:

• Anxiety and panic Asthma

• Bladder problems, cystitis

• Body aches

• Chronic bowel problems

• Diabetes type 2 &

metabolic syndrome

• Dysmenorrhea

• Eclampsia

• Fatigue

• Headaches, migraine

• Heart disease

• Hypertension

• Hypoglycemia

• Insomnia

• infertility

• Insulin resistanse

• Kidney Disease

• Leg cramps

MAGNESIUM DEFICIENCY – ASSOCIATED

DISEASES cont

• Liver Disease

• Low energi

• Musculoskeletal

conditions

• Muscle twitches

• Nerve problems

• Obesity

• Premenstrual syndrome

• Premature contractions

• Restless legs

• Stroke

• Sudden Infant

Death Syndrome

(SIDS)

• Raynaud's

Syndrome

• Tooth decay

MAGNESIUM & SEPSIS PROTECTION

• Magnesium replacement

provides significant protection

against endotoxin Salem M et al Crit Care Med 1995;23:108-118

• Administration of Mg to animals

with sepsis improves organ

function and survival time Harkema JM et al Crit Care Med 1992;20:263-275

HYPOMAGNESEMIA IN CRITICALLY ILLLimaye CS et al J Assoc Physicians India 2011;59:19-22

52% of patients show Mg-deficiency on

admission to MICU & suffer increased:

• Mortality rate (57.7% vs 31.7%)

• Need for ventilatory support (73% vs 53%)

• Duration of mechanical ventilation

(4.27 vs 2.15 days),

• Rate of sepsis (38% vs 19%)

• Hypocalcemia (69% vs 50%)

• Hypoalbuminemia (80.76% vs 70.8%)

MAGNESIUM – DAILY REQUIREMENT

Children: 1-3 years old: 80 milligrams

4-8 years old: 130 milligrams

9-13 years old: 240 milligrams

14-18 years old (boys): 410 milligrams

14-18 years old (girls): 360 milligrams

Adult: Females: 310 milligrams

Pregnancy: 360-400 milligrams

Breastfeeding women: 320-360 milligrams

Males: 400 milligram

2013-05-05

16

MAGNESIUM IN FOODS mg/100 gr

• Pumpkin &Squash seeds 540

• Cacao 20-22 % 520

• Wheat bran 355

• Sesame seeds 350

• Wheat germs 290

• Almonds 280

• Soya beans 265

• Cashew nuts 260

• Rosehip, dry 240

• OAT bran 235

• Peanuts 190

• Beans 190

• Peas 150

• Lentils 80

• Spinach 79

• Prunes 52

• Avocado 41

• Banana 35

• CHEESE 35

• Broccoli 23

• FRENCH FRIES 35

• BREAD, whole wheat 24

• HAMBURGERS 20

• KETCHUP 18

• MILK 15

• CREAM 14

• BUTTER 3

ZINC IN FOODS mg/100 g

(Daily need: 10 -15 mg) • Wheat germ 18

• Dry yeast 14

• Sesame seed 10.2

• Flaxseed, dry 7.8

• Pumpkin seed 7.5

• Squash seed 7.5

• Cacao 7.0

• Pecan nuts 5.5

• Sunflower seeds 5.1

• Liver 4-7

• BEEF 4-6

• Soy protein 4.4

• Brazil nuts 4.2

• Peas 3.8

• Lentils 3.1

• Peanuts 3.1

• BACON 3.0

• Walnuts 3.0

• CHEESE 2-3

• BREAD whole wheat 1

FRENCH FRIES 0.4

• Milk 0.4

• CREAM 0.3

• BREAD, Wheat 0

SELENO-ENZYMES DEFICIENCIESFoster HD Med Hypotheses 2007;69:1277-1280

• Selenium• depressed glutathione peroxidase

oxidative stress

• depressed CD4 T lymphocytes

• depressed trijodothyronine

• myocardial infarction

• Kaposi’s sarcoma

• depression

• Cysteine• depressed glutathione

• poor wound healing

• abnormal immune function

• psoriasis

• infections and cancers

• Glutamine• depression

• compromised gut barrier integrity

(relaxation of tight junctions)

• diarrhea

• muscle wasting

• Tryptophan• depressed niacin and serotonin

• immune incompetence

• neuroendocrine disregulation

• polyneuropathy

• dementia

• dermatitis

• diarrhea

CYSTEINE IN FOODSmg/100 gr food

• Wheat germs 750

• Gelatin 670 Lamb 600

• Sesami seeds 520

• Wheat bran 440

• Oat 390

• Almonds 360

• Walnuts 350

• Peanuts 340

• Beans, dried 315

• Soya beans, dried 310

• Chicken 290

• Turkey 280

• Parmesan cheese 270

• Peas, dried 240

• Lentils, dried 230

• HAMBURGERS 110

• CHEESE 100

• Banana 60

• Figs 60

• FRENCH FRIES 28

• KETCHUP 5

METHIONINE IN FOODSmg/100 g food

• Brazil nuts 1010

• Sesame seeds 900

• Cheese 900

• Gelatin 670

• Roast chicken 801 Swiss cheese 784

• Baked codfish 679

• Fish 600

• Chicken 570

• Beef 560

• Pumpkin seeds 550

• Roast ham 535

• Dry yeast 520

• Sunflower seeds 490

• Wheat germs 470

• Soya beans, dried 410

• Hard boiled egg 392

• HAMBURGERS 360

• Beans, dried 325

• Peanuts, dried 280

• Peas, dried 260

• Almonds 230

• Cereals app 200

• Lentils, dried 190

• Banana 75

• Tofu 74

• KETCHUP 11

VITAMIN K IN FOODS mcg/portion

• Brussels sprouts,1/2 cup 460

• Broccoli, 1/2 cup 248

• Cauliflower, 1/2 cup 150

• Swiss Chards * 1/2 cup 123

• Spinach, raw, 1 cup 120

• BEEF, 3.5 oz 104

• PORK, 3.5 oz 88

• EGGS, whole, large 25

• Strawberries, 1 cup 23

• Oats, 1oz, dry 18

• MILK, 8 oz, whole 10 * mangold

2013-05-05

17

HEALTH – TEN COMMANDMENTS

7 NOS (restrict) & 3 YES (increase) 1. Restrict intake of IGF-1-inducing foods (refined carbohydrates)

2. Restrict intake of IGF-1-rich foods (dairy products)

3. Restrict intake of highly pro-inflammatory fructose

4. Restrict intake of foods heated above 100o

5. Restrict exposure to in microbe-derived highly inflammatory

endotoxin

6. Restrict exposure to chemicals including pharmaceutical drugs

7. Eliminate/Minimize intake of foods rich in proteotoxins such as

casein, gluten and zein (corn)

8. Increase the intake of fresh and raw greens, fresh spices and

vegetables -

9. Increase intake of ancient anti-oxidant-rich, high fiber, low-calorie

containing grains, seeds, peas, beans, almonds & nuts

10. Supplement vitamin D and omega fatty acids in large doses

The Saddleback Church InitiativeCollective Loss of 260 000 lbs – 130 tonsRick Warren - The Daniel Plan Fotograf: Shaon Fox

SUBSTITUTING VITAMIN DGant WB et al Prog Biophys Mol Biol 2009, 99:104-113

to all European to 40 ng/mL would reduce the direct economic burden of disease by 11.4%, or EUR 105,000 000 000

the indirect economic burden of disease by 6.4 % or EUR 82,000 000 000

the total reduction in economic burden of disease by 17.7%, or

EUR 187,000 000 000