Development of CD8 + T cells in the thymus Raine Toivonen Double negative T cell Lymphoid progenitor Double positive T cell Cortical epithelial cell Death by Neglect due to Weak signalling CORTEX MEDULLA CD8 committed T cell CD4 committed T cell THYMUS Medullary epithelial cell Or Dendritic cell CD8 T cell Negative selection and death Positive selection TO THE PERIPHERY!
Development of CD8 + T cells in the thymus. THYMUS. Death by Neglect due to Weak signalling. Cortical epithelial cell. Medullary epithelial cell Or Dendritic cell. Lymphoid progenitor. Positive selection. CD8 committed T cell. CD8 T cell. TO THE PERIPHERY!. Negative selection - PowerPoint PPT Presentation
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Development of CD8+ T cells in the thymus
Raine Toivonen
Double negative T cell
Lymphoidprogenitor
Double positive T cell
Cortical epithelialcell
Death byNeglect due toWeak signalling
CORTEXMEDULLA
CD8 committed T cell
CD4 committed T cell
THYMUS
Medullary epithelial cellOr
Dendritic cell
CD8 T cell
Negative selectionand death
Positiveselection
TO THEPERIPHERY!
Activation of CD8+ T cells in the periphery
Raine Toivonen
CD8+ T CELL
AgTCR
CD28
IL-2IL-2
IL2R
IL2R
CD8
Dendritic cell
MHC I
CD80 / CD86
• CD8+ T cell encounters an activated APC
• The APC presents antigen on its surface within MHC I
• Antigens can be bound to MHC I either when they are synthesized within the cell (endogenous or viral antigens) or transferred from phagosomes to cytosolic compartment (cross-presentation of exogenous antigens)
• CD8 T cell produces IL-2 to drive its own proliferation
The DC is activated by CD4+ T cell: license to kill