Dachshunds and data: Developing a tool to help dog breeders predict genetic risks.

Dachshunds and DataDeveloping a tool to help dog breeders predict genetic risksOR56: Sept. 2014

Lafora disease and DNA testing.

Developing a tool

Overview

Learning and next

steps

Happy dogs and owners

Presented by Ian Seath & Sophie Carr

DNA tests Miniature Wirehaired Dachshunds

4 populations

2 tests available

Not consistently used

Tested and no recessive gene (clear)

Tested and non-symptomatic (carrier)

Known to suffer from epilepsy (Lafora disease)

Need to identify breeding pairs which may produce

affected puppies

Tested and symptomatic (affected)

Tested ”Not affected” (clear or carrier)

Identifies if the dog carries the recessive gene

Lafora disease and DNA testing

What is the probability of breeding an

affected puppy?

Has either parent dog had the DNA test?

Show dog?

Hobby breeder?Bred with the dog down the road?

If tested are the parent dogs:

clear; carriers or affected?

If the parent dogs have not been tested, do they show signs of being affected?

Underlying probabilities of a dog being clear, carrier or affected?

DataLots of unknowns and estimated values.

RequirementSimple, robust model which provides indicative results.

SolutionProbability trees.

1

2

3

Developing a tool

Clear

Affected

Carrier

0.4

5

0.1

0.45

Clear

Carrier

0.4

5

0.1

0.45

Affected

Clear

Carrier

Affected

0.75

0.25

0

When a carrier and clear dog breed, the resulting puppies can be clear or carriers – there are not two recessive genes present to allow for an affected puppy

Simple probability tree

THEORETICAL PROBABILITY OF PUPPIES WHICH ARECLEAR CARRIER AFFECTED

CLEAR TO CLEAR 1.000 0.000 0.000CLEAR TO AFFECTED 0.000 1.000 0.000CLEAR TO CARRIER 0.750 0.250 0.000CLEAR TO NOT AFFECTED 0.863 0.138 0.000CLEAR TO NOT TESTED 0.788 0.213 0.000CARRIER TO NOT AFFECTED 0.475 0.388 0.138NOT AFFECTED TO NOT AFFECTED 0.649 0.275 0.076CARRIER TO NOT TESTED 0.450 0.388 0.163NOT AFFECTED TO NOT TESTED 0.602 0.309 0.089NOT TESTED TO NOT TESTED 0.557 0.338 0.106AFFECTED TO NOT TESTED 0.000 0.675 0.325

The tool

The benefits

Increasing awareness

•Probability of breeding affected puppies

Informed decisions

•Robust, simple to use model

Simple methodology

• Investigate different breeding strategies

Predictive analysis

Enhance model methodology

Increased volume and accuracy of data

Review model assumptions

Investigate impact of new

breeding strategies

Future improveme

nts

• Ian Seath [email protected]

• Sophie Carr [email protected]

Thank you