Cyclooxygenase-2 (COX-2) Cyclooxygenase-2 (COX-2) overexpression overexpression is associated with a poor is associated with a poor prognosis prognosis in chondrosarcomas in chondrosarcomas Makoto Endo, Makoto Endo, 1 Tadaki Matsumura, Tadaki Matsumura, 2 Umio Umio Yamaguchi, Yamaguchi, 1 Fumihiko Nakatani, Fumihiko Nakatani, 1 Akira Kawai, Akira Kawai, 1 Hirokazu Hirokazu Chuman, Chuman, 1 Yasuo Beppu, Yasuo Beppu, 1 Tadashi Hasegawa Tadashi Hasegawa 2 1 Division of Orthopaedic Oncology, National Cancer Center Hospital, Division of Orthopaedic Oncology, National Cancer Center Hospital, Tokyo, Japan Tokyo, Japan 2 Department of Clinical Pathology, Sapporo Medical University School Department of Clinical Pathology, Sapporo Medical University School of Medicine, of Medicine, 12 th CTOS Annual Meeting in Venice, Italy 2-4, November, 2006
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Cyclooxygenase-2 (COX-2) overexpression is associated with a poor prognosis in chondrosarcomas
12 th CTOS Annual Meeting in Venice, Italy 2-4, November, 2006. Cyclooxygenase-2 (COX-2) overexpression is associated with a poor prognosis in chondrosarcomas. Makoto Endo, 1 Tadaki Matsumura, 2 Umio Yamaguchi, 1 Fumihiko Nakatani, 1 Akira Kawai, 1 Hirokazu Chuman, 1 - PowerPoint PPT Presentation
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Cyclooxygenase-2 (COX-2) overexpressionCyclooxygenase-2 (COX-2) overexpressionis associated with a poor prognosis is associated with a poor prognosis
11 Division of Orthopaedic Oncology, National Cancer Center Hospital, Tokyo, Japan Division of Orthopaedic Oncology, National Cancer Center Hospital, Tokyo, Japan22 Department of Clinical Pathology, Sapporo Medical University School of Medicine, Department of Clinical Pathology, Sapporo Medical University School of Medicine,
Sapporo, JapanSapporo, Japan
12th CTOS Annual Meeting in Venice, Italy2-4, November, 2006
BackgroundBackground
Chondrosarcoma
The second most common
malignant bone tumor A broad array of presentations The histologic grade is the standard
for predicting the outcome
12th CTOS Annual Meeting in Venice, Italy2-4, November, 2006
The he histologic grading system is
separated into three grades Based on
1. cellularity
2. nuclear atypia
3. pleomorphism
12th CTOS Annual Meeting in Venice, Italy2-4, November, 2006
Grading of chondrosarcomas
Fletcher CDM, et al (eds): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone, 2002.
In some borderline cases, exact histologic grading is
difficult using only routine histopathologic examinations
12th CTOS Annual Meeting in Venice, Italy2-4, November, 2006
Grade 1 Grade 3 Grade 2
Cyclooxygenase-2(COX-2) An isoform of COX A key enzyme that catalyzes the synthesis of prostaglandins (PGs) from arachidonic acid COX-2-derived PGs play an important role in carcinogenesis
1. induce angiogenesis2. inhibit apoptosis and immune surveillance3. increase invasion and metastatic potential
12th CTOS Annual Meeting in Venice, Italy2-4, November, 2006
To investigate the expression profile of investigate the expression profile of
COX-2 using immunohistochemical stainingCOX-2 using immunohistochemical staining
in formalin-fixed, in formalin-fixed, paraffin-embedded
chondrosarcoma specimenschondrosarcoma specimens
To confirm whether COX-2 expression isTo confirm whether COX-2 expression is
associated with prognosisassociated with prognosis
12th CTOS Annual Meeting in Venice, Italy2-4, November, 2006