Customized IOLs Customized IOLs - - Post Insertion Post Insertion Christian A. Sandstedt, Ph.D. Christian A. Sandstedt, Ph.D. Calhoun Vision, Inc Calhoun Vision, Inc Pasadena, CA Pasadena, CA 4 4 th th International Conference of International Conference of Wavefront Sensing and Wavefront Sensing and Aberration Aberration - - Free Refractive Free Refractive Correction Correction San Francisco, CA San Francisco, CA February 15, 2003 February 15, 2003
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Customized IOLs-Post Insertionvoi.opt.uh.edu/VOI/WavefrontCongress/2003/presentations...Customized IOLs-Post Insertion Christian A. Sandstedt, Ph.D. Calhoun Vision, Inc Pasadena, CA
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Customized IOLsCustomized IOLs--Post InsertionPost InsertionChristian A. Sandstedt, Ph.D.Christian A. Sandstedt, Ph.D.
Calhoun Vision, IncCalhoun Vision, IncPasadena, CAPasadena, CA
44thth International Conference of International Conference of Wavefront Sensing and Wavefront Sensing and
Non-Invasive Alteration of IOL Power Post-OperativelyNonNon--Invasive Alteration of Invasive Alteration of
IOL Power PostIOL Power Post--OperativelyOperativelyFoldable IOL made of photosensitive material
Adjust IOL power post-operatively by treating with safe levels of light to alter its refractive properties
Foldable IOL made of photosensitive materialFoldable IOL made of photosensitive material
Adjust IOL power postAdjust IOL power post--operatively by treating operatively by treating with safe levels of light to alter its refractive with safe levels of light to alter its refractive propertiesproperties
Measurements made in double passThe number of interference fringes (OPD) proportional to the induced power change
Measurements made in double passMeasurements made in double passThe number of interference fringes (OPD) proportional to The number of interference fringes (OPD) proportional to the induced power changethe induced power change
Pre-irradiation +20 D LAL –2 D Correction
Sample In Vitro NomogramSample In Vitro NomogramSample In Vitro Nomogram
The intensity is kept constant and the time is varied The intensity is kept constant and the time is varied The intensity is kept constant and the time is varied
-2.0
-1.5
-1.0
-0.5
0.00 1 2 3 4 5 6 7 8 9
Dose #
∆D
iopt
ers
Method of LAL Optical Characterization: MTFMethod of LAL Optical Method of LAL Optical Characterization: MTFCharacterization: MTF
MTF measurements made in a wet cell with the ISO prescribed model eyeMTF of LAL comparable to commercial IOL
MTF measurements made in a wet cell with the ISO MTF measurements made in a wet cell with the ISO prescribed model eyeprescribed model eyeMTF of LAL comparable to commercial IOLMTF of LAL comparable to commercial IOL
Measurements made in double passThe number of interference fringes (OPD) proportional to the induced power change
Measurements made in double passMeasurements made in double passThe number of interference fringes (OPD) proportional to The number of interference fringes (OPD) proportional to the induced power changethe induced power change
Astigmatic Correction:3.50 D ± 0.15 Dof Toric Correction
Classic Astigmatic Wavefront
Multifocality
- Treatment of Presbyopia Without Need forAccommodation
- Embodiments- Diffractive Optics
- Refractive Optics- Central Add and Central Subtract- Repeating Zones (Allergan Array)
Calhoun CapabilitiesCalhoun Capabilities
Predictable Achievement of EmmetropiaMultifocal IOL Centered on Visual AxisCustomizable Zone SizeCenter Add and/or SubtractPotential Non Invasive Reversibility
Multifocality After Two Corrections
+2.0 D Add in Center 2 mm Zone Size
Patient with +22.5 D LAL –2.0 D Post-Op Myopic Error
Light Adjustment
In Situ Creation of MF
Removal of -0.5 D Of Power
Removal of –1.5 D Of Power
Light Adjustment
Digital Light Delivery DeviceDigital Light Delivery DeviceDigital Light Delivery DeviceBreadboard System Developed in Collaboration with Carl Zeiss-Meditech AGAllows Researcher/Physician Control of Applied Spatial Intensity Pattern
Digital Light Delivery DeviceDigital Light Delivery DeviceDigital Light Delivery Device
( ) θρ−ρ= 2cos34I 22Tetrafoil
Tetrafoil Bitmap Spatial Intensity Pattern for Input to the DMD
Different annular zones of a lens focus at different points along the optical axis
CauseCauseOPD between the paraxial and marginal rays OPD between the paraxial and marginal rays
Different annular zones of a lens focus at different Different annular zones of a lens focus at different points along the optical axispoints along the optical axis
Irradiation of an annular ring on the periphery of the LAL
Note the removal of ~2 fringes (1 Wave) of LSA
Treatment CorrectionTreatment CorrectionIrradiation of an annular ring on the periphery of the Irradiation of an annular ring on the periphery of the LALLAL
Note the removal of ~2 fringes (1 Wave) of LSA Note the removal of ~2 fringes (1 Wave) of LSA
Preirradiation 24 hours Post Irradiation
What The LAL Can DoWhat The LAL Can DoWhat The LAL Can Do
Correct spherical errors with high reproducibility and repeatibiltyMaintain optical quality through the entire treatment procedure Astigmatic correctionsCustomized BifocalityHigher order aberrations
All of these once it has been implanted in the eye!