Cours du 14-10-2013 - Collège de France · 2013-12-17 · Fig. 4. Repair of single stranded lesions. Figure shows a simplified model for single strand break repair (SSBR) and transcription-coupled

Page 1 <img data-url='document/cours-du-14-10-2013-collge-de-france-2013-12-17-fig-4-repair-of-single-stranded.html?page=1' data-page='1' class='cut-thumb lazyload' alt='Page 1: Cours du 14-10-2013 - Collège de France · 2013-12-17 · Fig. 4. Repair of single stranded lesions. Figure shows a simplified model for single strand break repair (SSBR) and transcription-coupled' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022042117/5e951297558f9f56ae2c8fae/html5/thumbnails/1.jpg' width='140' height='200' /> Cours du 14‐10‐2013

Longévité cérébrale

Page 2 <img data-url='document/cours-du-14-10-2013-collge-de-france-2013-12-17-fig-4-repair-of-single-stranded.html?page=2' data-page='2' class='cut-thumb lazyload' alt='Page 2: Cours du 14-10-2013 - Collège de France · 2013-12-17 · Fig. 4. Repair of single stranded lesions. Figure shows a simplified model for single strand break repair (SSBR) and transcription-coupled' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022042117/5e951297558f9f56ae2c8fae/html5/thumbnails/2.jpg' width='140' height='200' /> Page 3 <img data-url='document/cours-du-14-10-2013-collge-de-france-2013-12-17-fig-4-repair-of-single-stranded.html?page=3' data-page='3' class='cut-thumb lazyload' alt='Page 3: Cours du 14-10-2013 - Collège de France · 2013-12-17 · Fig. 4. Repair of single stranded lesions. Figure shows a simplified model for single strand break repair (SSBR) and transcription-coupled' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022042117/5e951297558f9f56ae2c8fae/html5/thumbnails/3.jpg' width='140' height='200' /> Page 4 <img data-url='document/cours-du-14-10-2013-collge-de-france-2013-12-17-fig-4-repair-of-single-stranded.html?page=4' data-page='4' class='cut-thumb lazyload' alt='Page 4: Cours du 14-10-2013 - Collège de France · 2013-12-17 · Fig. 4. Repair of single stranded lesions. Figure shows a simplified model for single strand break repair (SSBR) and transcription-coupled' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022042117/5e951297558f9f56ae2c8fae/html5/thumbnails/4.jpg' width='140' height='200' /> TDP1: tyrosil‐DNA phosphodiesteraseAPTX: aprataxinPNKP: polynucleotide kinase 3’‐phosphatase

Page 5 <img data-url='document/cours-du-14-10-2013-collge-de-france-2013-12-17-fig-4-repair-of-single-stranded.html?page=5' data-page='5' class='cut-thumb lazyload' alt='Page 5: Cours du 14-10-2013 - Collège de France · 2013-12-17 · Fig. 4. Repair of single stranded lesions. Figure shows a simplified model for single strand break repair (SSBR) and transcription-coupled' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022042117/5e951297558f9f56ae2c8fae/html5/thumbnails/5.jpg' width='140' height='200' /> Page 6 <img data-url='document/cours-du-14-10-2013-collge-de-france-2013-12-17-fig-4-repair-of-single-stranded.html?page=6' data-page='6' class='cut-thumb lazyload' alt='Page 6: Cours du 14-10-2013 - Collège de France · 2013-12-17 · Fig. 4. Repair of single stranded lesions. Figure shows a simplified model for single strand break repair (SSBR) and transcription-coupled' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022042117/5e951297558f9f56ae2c8fae/html5/thumbnails/6.jpg' width='140' height='200' /> H1H1

histone sur DNA linkerparticipe au “packing” du nucléosome

Page 7 <img data-url='document/cours-du-14-10-2013-collge-de-france-2013-12-17-fig-4-repair-of-single-stranded.html?page=7' data-page='7' class='cut-thumb lazyload' alt='Page 7: Cours du 14-10-2013 - Collège de France · 2013-12-17 · Fig. 4. Repair of single stranded lesions. Figure shows a simplified model for single strand break repair (SSBR) and transcription-coupled' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022042117/5e951297558f9f56ae2c8fae/html5/thumbnails/7.jpg' width='140' height='200' /> γH2AX

Page 8 <img data-url='document/cours-du-14-10-2013-collge-de-france-2013-12-17-fig-4-repair-of-single-stranded.html?page=8' data-page='8' class='cut-thumb lazyload' alt='Page 8: Cours du 14-10-2013 - Collège de France · 2013-12-17 · Fig. 4. Repair of single stranded lesions. Figure shows a simplified model for single strand break repair (SSBR) and transcription-coupled' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022042117/5e951297558f9f56ae2c8fae/html5/thumbnails/8.jpg' width='140' height='200' /> Page 9 <img data-url='document/cours-du-14-10-2013-collge-de-france-2013-12-17-fig-4-repair-of-single-stranded.html?page=9' data-page='9' class='cut-thumb lazyload' alt='Page 9: Cours du 14-10-2013 - Collège de France · 2013-12-17 · Fig. 4. Repair of single stranded lesions. Figure shows a simplified model for single strand break repair (SSBR) and transcription-coupled' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022042117/5e951297558f9f56ae2c8fae/html5/thumbnails/9.jpg' width='140' height='200' /> ? plutôt le contraire ?

Page 10 <img data-url='document/cours-du-14-10-2013-collge-de-france-2013-12-17-fig-4-repair-of-single-stranded.html?page=10' data-page='10' class='cut-thumb lazyload' alt='Page 10: Cours du 14-10-2013 - Collège de France · 2013-12-17 · Fig. 4. Repair of single stranded lesions. Figure shows a simplified model for single strand break repair (SSBR) and transcription-coupled' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022042117/5e951297558f9f56ae2c8fae/html5/thumbnails/10.jpg' width='140' height='200' /> Page 11 <img data-url='document/cours-du-14-10-2013-collge-de-france-2013-12-17-fig-4-repair-of-single-stranded.html?page=11' data-page='11' class='cut-thumb lazyload' alt='Page 11: Cours du 14-10-2013 - Collège de France · 2013-12-17 · Fig. 4. Repair of single stranded lesions. Figure shows a simplified model for single strand break repair (SSBR) and transcription-coupled' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022042117/5e951297558f9f56ae2c8fae/html5/thumbnails/11.jpg' width='140' height='200' /> Page 12 <img data-url='document/cours-du-14-10-2013-collge-de-france-2013-12-17-fig-4-repair-of-single-stranded.html?page=12' data-page='12' class='cut-thumb lazyload' alt='Page 12: Cours du 14-10-2013 - Collège de France · 2013-12-17 · Fig. 4. Repair of single stranded lesions. Figure shows a simplified model for single strand break repair (SSBR) and transcription-coupled' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022042117/5e951297558f9f56ae2c8fae/html5/thumbnails/12.jpg' width='140' height='200' /> Page 13 <img data-url='document/cours-du-14-10-2013-collge-de-france-2013-12-17-fig-4-repair-of-single-stranded.html?page=13' data-page='13' class='cut-thumb lazyload' alt='Page 13: Cours du 14-10-2013 - Collège de France · 2013-12-17 · Fig. 4. Repair of single stranded lesions. Figure shows a simplified model for single strand break repair (SSBR) and transcription-coupled' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022042117/5e951297558f9f56ae2c8fae/html5/thumbnails/13.jpg' width='140' height='200' /> Page 14 <img data-url='document/cours-du-14-10-2013-collge-de-france-2013-12-17-fig-4-repair-of-single-stranded.html?page=14' data-page='14' class='cut-thumb lazyload' alt='Page 14: Cours du 14-10-2013 - Collège de France · 2013-12-17 · Fig. 4. Repair of single stranded lesions. Figure shows a simplified model for single strand break repair (SSBR) and transcription-coupled' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022042117/5e951297558f9f56ae2c8fae/html5/thumbnails/14.jpg' width='140' height='200' /> Replicative Senescence, Chronological aging

Oncogne‐induced senescence

Hutchinson‐Gilford Progeria Syndrom

Caloric Restriction

Page 15 <img data-url='document/cours-du-14-10-2013-collge-de-france-2013-12-17-fig-4-repair-of-single-stranded.html?page=15' data-page='15' class='cut-thumb lazyload' alt='Page 15: Cours du 14-10-2013 - Collège de France · 2013-12-17 · Fig. 4. Repair of single stranded lesions. Figure shows a simplified model for single strand break repair (SSBR) and transcription-coupled' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022042117/5e951297558f9f56ae2c8fae/html5/thumbnails/15.jpg' width='140' height='200' /> Page 16 <img data-url='document/cours-du-14-10-2013-collge-de-france-2013-12-17-fig-4-repair-of-single-stranded.html?page=16' data-page='16' class='cut-thumb lazyload' alt='Page 16: Cours du 14-10-2013 - Collège de France · 2013-12-17 · Fig. 4. Repair of single stranded lesions. Figure shows a simplified model for single strand break repair (SSBR) and transcription-coupled' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022042117/5e951297558f9f56ae2c8fae/html5/thumbnails/16.jpg' width='140' height='200' /> 16

Page 17 <img data-url='document/cours-du-14-10-2013-collge-de-france-2013-12-17-fig-4-repair-of-single-stranded.html?page=17' data-page='17' class='cut-thumb lazyload' alt='Page 17: Cours du 14-10-2013 - Collège de France · 2013-12-17 · Fig. 4. Repair of single stranded lesions. Figure shows a simplified model for single strand break repair (SSBR) and transcription-coupled' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022042117/5e951297558f9f56ae2c8fae/html5/thumbnails/17.jpg' width='140' height='200' />