PHOTO: GERRY ELLIS/MINDEN PICTURES 25 SEPTEMBER 2020 • VOL 369 ISSUE 6511 1539 SCIENCE sciencemag.org 25 SEPTEMBER 2020 • VOLUME 369 • ISSUE 6511 1558 Costa Rica’s biodiversity has been a magnet for outside scientists. NEWS IN BRIEF 1548 News at a glance IN DEPTH 1550 Flawed interferon response spurs severe illness Antibodies or mutations that cripple key antivirus protein underlie 14% of severe cases By M. Wadman RESEARCH ARTICLE BY Q. ZHANG ET AL. DX.DOI.ORG/10.1126/SCIENCE.ABD4570; RESEARCH ARTICLE BY P. BASTARD ET AL. DX.DOI.ORG/10.1126/SCIENCE.ABD4585 1551 Fighting to be counted The pandemic has fueled Abigail Echo-Hawk’s quest for health data on Indigenous people in the United States By L. Wade 1553 Despite obstacles, WHO unveils plan to distribute vaccine Nations with nearly two-thirds of world’s population have joined, but not the United States, Russia, or China By K. Kupferschmidt 1554 Turkey targets critics of its pandemic response Researchers and physicians who question data or policies face lengthy investigations By K. McTighe 1555 Curved scour marks trace the directions of ancient quakes “Slickenlines” etched in rocks could help refine shaking hazard for cities near the ends of faults By P. Voosen 1565 The last pieces of a puzzling early meeting Y chromosomes transferred from Homo sapiens to Neanderthals between 350,000 to 150,000 years ago By M. H. Schierup REPORT p. 1653 1567 Birds do have a brain cortex— and think Like mammals, birds have a pallium that sustains correlates of consciousness By S. Herculano-Houzel RESEARCH ARTICLE p. 1585; REPORT p. 1626 1568 Intense x-rays can be (slightly) exciting Imaging of neutral “survivor” atoms excited by x-ray blasts fights radiation damage By T. Pfeifer REPORT p. 1630 POLICY FORUM 1570 Self-experimentation, ethics, and regulation of vaccines DIY COVID-19 vaccines raise legal and ethical questions By C. J. Guerrini et al. BOOKS ET AL. 1573 Understanding quantum cause and effect Correlations at a distance needn’t necessarily be “spooky” By A. Stairs 1574 The race to decipher Egyptian hieroglyphs A pair of scholars recount the rivalry that defined efforts to interpret the Rosetta stone By A. Robinson 1556 The short, strange life of quantum radar In spite of military interest, quantum mechanics won’t defeat stealth technologies By A. Cho 1557 Sizing up a green carbon sink Studies zero in on forests’ potential to fight warming By G. Popkin FEATURES 1558 Seeking a niche Costa Rica is producing a new generation of skilled tropical biologists. But many can’t find jobs at home By J. Kaiser 1561 A tropical research treasure faces difficult times By J. Kaiser CONTENTS INSIGHTS PERSPECTIVES 1562 Transformative tools for parasitic flatworms Schistosome single-cell atlas and genome-wide functional dissection reveal druggable targets By T. J. C. Anderson and M. T. Duraisingh REPORTS pp. 1644 & 1649 1564 Preventing pores and inflammation Metabolite-directed modification of pore-forming cell death protein limits inflammation By R. J. Pickering and C. E. Bryant REPORT p. 1633 Published by AAAS on February 2, 2021 http://science.sciencemag.org/ Downloaded from
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25 SEPTEMBER 2020 • VOL 369 ISSUE 6511 1539SCIENCE sciencemag.org
25 SEPTEMBER 2020 • VOLUME 369 • ISSUE 6511
1558Costa Rica’s biodiversity
has been a magnet
for outside scientists.
NEWS
IN BRIEF
1548 News at a glance
IN DEPTH
1550 Flawed interferon response spurs severe illnessAntibodies or mutations that cripple key antivirus protein underlie 14% of severe cases By M. Wadman
RESEARCH ARTICLE BY Q. ZHANG ET AL.
DX.DOI.ORG/10.1126/SCIENCE.ABD4570;
RESEARCH ARTICLE BY P. BASTARD ET AL.
DX.DOI.ORG/10.1126/SCIENCE.ABD4585
1551 Fighting to be countedThe pandemic has fueled Abigail Echo-Hawk’s quest for health data on Indigenous people in the United States By L. Wade
1553 Despite obstacles, WHO unveils plan to distribute vaccineNations with nearly two-thirds of world’s population have joined, but not the United States, Russia, or China By K. Kupferschmidt
1554 Turkey targets critics of its pandemic responseResearchers and physicians who question data or policies face lengthy investigations By K. McTighe
1555 Curved scour marks trace the directions of ancient quakes“Slickenlines” etched in rocks could help refine shaking hazard for cities near the ends of faults By P. Voosen
1565 The last pieces of a puzzlingearly meetingY chromosomes transferred from Homo sapiens to Neanderthals between 350,000 to 150,000 years ago By M. H. Schierup
REPORT p. 1653
1567 Birds do have a brain cortex—and thinkLike mammals, birds have a pallium that sustains correlates of consciousness By S. Herculano-Houzel
RESEARCH ARTICLE p. 1585; REPORT p. 1626
1568 Intense x-rays can be (slightly) excitingImaging of neutral “survivor” atoms excited by x-ray blasts fights radiation damage By T. Pfeifer
REPORT p. 1630
POLICY FORUM
1570 Self-experimentation, ethics, and regulation of vaccinesDIY COVID-19 vaccines raise legal and ethical questions By C. J. Guerrini et al.
BOOKS ET AL.
1573 Understanding quantumcause and effectCorrelations at a distance needn’t necessarily be “spooky” By A. Stairs
1574 The race to decipher Egyptian hieroglyphsA pair of scholars recount the rivalry that defined efforts to interpret the Rosetta stone By A. Robinson
1556 The short, strange life of quantum radarIn spite of military interest, quantum
mechanics won’t defeat stealth
technologies By A. Cho
1557 Sizing up a green carbon sinkStudies zero in on forests’ potential to fight
warming By G. Popkin
FEATURES
1558 Seeking a nicheCosta Rica is producing a new generation
of skilled tropical biologists. But many can’t
find jobs at home By J. Kaiser
1561 A tropical research treasure
faces difficult times By J. Kaiser
CONTENTS
INSIGHTS
PERSPECTIVES
1562 Transformative tools for parasitic flatwormsSchistosome single-cell atlas and genome-wide functional dissection reveal druggable targets By T. J. C. Anderson and M. T. Duraisingh
REPORTS pp. 1644 & 1649
1564 Preventing pores and inflammationMetabolite-directed modification of pore-forming cell death protein limits inflammation By R. J. Pickering and C. E. Bryant
25 SEPTEMBER 2020 • VOL 369 ISSUE 6511 1541SCIENCE sciencemag.org
RESEARCH
IN BRIEF
1579 From Science and other journals
REVIEW
1582 ImmunologyThe science and medicine of human immunology B. Pulendran and M. M. Davis
REVIEW SUMMARY; FOR FULL TEXT:
DX.DOI.ORG/10.1126/SCIENCE.AAY4014
RESEARCH ARTICLES
1583 Structural biologyThe endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase M. J. McKenna et al.RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:
DX.DOI.ORG/10.1126/SCIENCE.ABC5809
1584 Prebiotic chemistrySynthetic connectivity, emergence, and self-regeneration in the network of prebiotic chemistry A. Wołos et al.RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:
DX.DOI.ORG/10.1126/SCIENCE.AAW1955
1585 NeuroscienceA cortex-like canonical circuit in the avian forebrain M. Stacho et al.RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:
DX.DOI.ORG/10.1126/SCIENCE.ABC5534
PERSPECTIVE p. 1567
1586 CoronavirusDistinct conformational states of SARS-CoV-2 spike protein Y. Cai et al.
1592 Chemical physicsRotational resonances in the H2CO roaming reaction are revealed by detailed correlations M. S. Quinn et al.
1597 GrapheneInducing metallicity in graphene nanoribbons via zero-mode superlattices D. J. Rizzo et al.
1603 CoronavirusAdaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy H. Gu et al.
1608 Immune systemsThe immunogenetics of sexual parasitism J. B. Swann et al.
REPORTS
1615 Solar cellsStable perovskite solar cells with efficiency exceeding 24.8% and 0.3-V voltage loss M. Jeong et al.
1621 Ocean temperatureHigh-impact marine heatwaves attributable to human-induced global warming C. Laufkötter et al.
1626 ConsciousnessA neural correlate of sensory consciousness in a corvid bird A. Nieder et al.PERSPECTIVE P. 1567
ON THE COVER
The ancestors of the carrion crow diverged from the mammalian lineage as early as 320 million years ago. Carrion crow brain activity suggests that sensory consciousness developed either before the emergence
of mammals or independently in the avian lineage and may not require a cerebral cortex, as we know it. See pages 1567 and 1626. Photo: Tobias Machts, University of Tübingen
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