Congratulations to the HSDM Class of 2015Congratulations to the HSDM Class of 2015 . 2 Research Bulletin • May – June 2015 • Harvard School of Dental Medicine Research Day Poster

May – June 2015ReseaRch Bulletin

Peter Fung, DMD, received the Quintessence Award in Research and Honors in Research. At HSDM, Fung worked on, “DNA Nanotechnology for Programmable Targeting and Localization to Tumor Cells” in the Yin Lab at the Wyss Institute. After graduation, he will join NIDCR as a postdoctoral fellow in the Craniofacial Anomalies and Regeneration Section.

Gino inverso, DMD, received the American Association of Oral Biologists’ Award and Honors in Research. Inverso’s research, “Extracting Value from Oral and Maxillofacial Surgery,” was completed under the mentorship of Drs. John Meara and Bonnie Padwa.

Michael Jungwirth, DMD, received the Harvard Odontological Award. Jungwirth spent a year working on, “Non-Endothelial Origin of Midpalatal Suture Osteoblasts,” under the mentorship of Dr. Bjorn R. Olsen and Dr. Wei Huang.

arthur Kim, DMD, received the Grace Milliken Award and Honors in Research. Kim’s research, “Guided Bone Regeneration: Effect of Solid Freeform Fabrication-Based Polycaprolactone/ Poly(lactic-co-glycolic acid)/Collagen Scaffolds on Cellular Activities of Human Adipose-Derived Stem Cells and Rat Primary Hepatocytes,” was completed under the mentorship of Dr. David Kim.

scott Parker irwin, DDs, MPh, certificate (Dental Public health), received the James M. Dunning Award. Irwin’s research, “Dental Diagnostic Codes in the US Air Force,” was completed under the mentorship of Drs. Christine Riedy and Mary Tavares.

abdulmonem alshihri, BDs, DMsc, certificate (implant Dentistry), received the AAID Post-Doctoral Student Award. After receiving his DMSc in Prosthdontics from HSDM in 2014, Alshiri entered the Implantology Program and continued his research with Dr. Myron Spector. His project was, “The Effects of Physical and Chemical Stimulation of Mesenchymal Stem Cells in an Injectable Hydrogel for Bone

Reconstruction.”

hawazin elani, DDs, PhD, MMsc (Prosthodontics), received the Lois K. Cohen Award. Elani’s research, “Socioeconomic Inequalities and Oral Health: A Multi-Country Study,” was completed under the mentorship of Dr. Ichiro Kawachi in the Department of Social and Behavioral Sciences at HSPH. Elani continues to expand trans-national collaborations and work cross-culturally to compare and contrast

different health systems and social policies in finding solutions for common oral health problems.

Mindy Gil, DMD, DMsc (Periodontology), received the Joseph L. Henry Award Award. After graduating from HSDM with her DMD degree, Gil matriculated into the DMSc program in Prosthodontics in 2011, where she continued her research with Dr. Shigemi Nagai. Gil’s DMSc thesis research was enttiled, “Comprehensive Optical Assessment of the Peri-Implant Mucosa.”

chin-Wei (Jeff) Wang, DDs, DMsc (Periodontology), received the James H. Shaw Award. Wang’s DMSc thesis research, “Pro-Resolving Maresins in Inflammation: New Pathway and Mechanisms with Oral Pathogens,” was completed under the mentorship of Dr. Charles Serhan in the Department of Experimental Therapeutics and Reperfusion Injury at Brigham and Women’s Hospital.

Congratulations to the HSDM Class of 2015

2 Research Bulletin • May – June 2015 • Harvard School of Dental Medicine

Research Day Poster Awardsnaeem ali, DMD 2015Change in Mandibular Position in Patients with Syndromic Craniosynostosis after Midfacial Advancement with Distraction Osteogenesis (Mentor, Dr. Bonnie Padwa)

Michelle chou, DDs, DMsc 2016 (Orthodontics) Saturation of Biological Response to Orthodontic Forces and its Effect on Tooth Movement (Mentors, Drs. Mani Alikhani and Mohammed Masoud)

lauren Manning, DDs, DMsc 2015 (Prosthodontics) Experimental Evaluation of DDR2 as an Ideal Target for Development of Disease-Modifying Osteoarthritis Drugs (Mentor, Dr. Yefu Li)

henry Ohiomoba, BDs, MPh, MMsc 2015 (Orthodontics)Quantitative Evaluation of Maxillary Alveolar Cortical Bone Thickness and Density Using Computed Tomography Imaging (Mentor, Dr. Andrew Sonis)

Michael sunwoo, DDs, MMsc 2015 (Orthodontics) Using Triggers to Document Orthodontic Adverse Events in the Academic Setting (Mentor, Dr. Elsbeth Kalenderian)

Yau-hua Yu, DDs, DMsc, MMsc 2015 (Periodontology)Cardiovascular Risks Associated with Incident and Prevalent Periodontal Disease (Mentor, Dr. Paul Ridker)

Jeff Wang, DDs, DMsc 2015 (Periodontology) Maresin 1 Rescues Impaired Phagocyte Functions with Localized Aggressive Periodontitis Leukocytes (Mentor, Dr. Charles Serhan)

Thank you to the poster reviewers: Drs. Bjorn R. Olsen, Elsbeth Kalenderian, Tanya Besschetnova, Nina Anderson, Agnes Berendsen, Francesca Gori, Beppe Intini, Porsche Jumlongras, Toshi Kawai, Sang Lee, Chia-Cheng Li, Hiroe Ohyama, Sang Park, Christine Riedy, Brittany Seymour, Mary Tavares, Yingzi Yang, and Ms. Jane Barrow.

Donald Giddon, DMD, PhD, Endowed Lecture

Bruce S. McEwen, PhD, Alfred E. Mirsky Professor and Head of the Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology at The Rockefeller University, was this year’s guest speaker for the Professor Donald B. Gid-don, DMD, PhD Annual Lec-ture in Behavioral Medicine and Dentistry. Dr. McEwen, (photographed above with Dr. Bruce Donoff), presented, “The Brain on Stress: Epigenetic Mechanisms of Brain Plasticity Through the Life Course.”

Cameron Lee Receives the 2015 ADA/Dentsply Student Clinician Award

Cameron Lee, DMD Honors in Research Candidate, in the class of 2016, (photographed here with Joel Monteiro from Dentsply Interna-tional), received the 2015 Student

Clinician Award. Lee conducted his HSDM honor’s re-search project in the HSDM department of oral and maxil-lofacial surgery/MGH Skeletal Biology Research Center with Dr. Zachary Peacock. For this work, “Orthognathic Surgery in Patients Over 40 Years of Age: Incidence and Special Considerations,” he received a 2015 ADEA Gies Foundation Fellowship. He also worked in the BWH Divi-sion of Plastic and Reconstructive Surgery/Laboratory of Tissue Repair and Gene Transfer with Drs. Edward Cater-son and Elof Eriksson. Lee has published many papers in his three years at HSDM, including first author publica-tions in journals such as: Plastic and Reconstructive Sur-gery; Journal of Oral and Maxillofacial Surgery; Internation-al Wound Journal; Journal of Craniofacial Surgery; and, the Journal of Wound Technology. Lee received several awards and honors as a DMD student, including: 2013 Hinmann Excellence in Research Award; 2013 BWH Plastic Surgery Training Award; 2013 MGH Oral and Maxillofaical Sur-gery Training Award; and, the 2014 Journal of Oral and Maxillofaical Surgery Issue Highlight.

An

ne-M

arie

For

d

Anne

-Mar

ie F

ord

Research Bulletin • May – June 2015 • Harvard School of Dental Medicine 3

AGE & DMD Student Research Presentations

Lauren B. Manning, DDS, DMSc (Prosthodonitcs), won first place in the 2015 American Prosthodontics Society Graduate Research Competition. Manning gave an oral presentation to the congress at the 87th Annual Meeting in Chicago. The presentation, “Experimental Evaluation of DDR2 as an Ideal Target for the Development of Disease Modifying Osteoarthritis Drugs,” was completed under the mentorship of Dr. Yefu Li.

Adam Patenaude DMD Class of 2017, presented, “Tissue Engineered Bone with Three-Dimensionally Printed b-TCP/PCL Scaffolds and Early Implantation: In Vivo Study in a Porcine Mandible Model” at the Massachusetts General Hospital Strategic Advisory Committee Research Day on April 2, 2015. There were two-hundred posters and Patenaude’s poster was selected as one of the 30 finalists by the poster judging panel. This was an honor as the vast majority of these posters were presented by postdoctroal fellows. He worked on this project under the mentorship of Dr. Maria Troulis. Patenaude is photographed above with Dr. Leonard Kaban (left) and Dr. Maria Troulis (right).

Lauren Hum, DMD Class of 2016, won 2nd place in the American Dental Education Associaton/Dentsply student poster competition at the annual session in March. Hum

presented her research, “The Junior Faculty Experience: Development of Teaching Skills,” under the mentorship of Dr. Sang Park.

Krakow Harvard/Forsyth Endowed Endodontic Research Fund AwardsThe Department of Restorative Dentistry and Biomaterials Sciences at HSDM is pleased to announce the recipients of the 2015 Krakow Awards. The purpose of these awards is to stimulate endodontic research and strengthen the scientific foundation of this specialty.

Dr. abdullah albassam A Study of Possible Anti-Bone Loss Effect by a Novel Endodontic Material, Bio-Ceramics (Mentor, Dr. Toshi Kawai)

Dr. Ziyad allahem Evaluation of TGFβ Role in Periapical Periodontitis (Mentor, Dr. Susan Rittling)

Dr. Mariana alves Comparison of Efficacy of Removal of 2% Chlorhexidine Gluconate Gel and Calcium Hydroxide When Used as Intracanal Medicaments and Evaluation of Coronal Discoloration Induced by 2% Chlorhexidine Gluconate Gel When Used as an Intracanal Medicament (Mentor, Dr. Robert White)

Dr. ana andrada The Therapeutic Effect of Resolvin E-1 in Murine Endodontic Infection and Inflammation (Mentor, Dr. Hajime Sasaki)

Dr. ian Grayson A Comparison of Sodium Hypochlorite Penetration into Dentinal Tubules With and Without the Presence of Various Surfactants (Mentor, Dr. Toshi Kawai)

Dr. Kimberley ung In Vitro Comparison of Two Infection Control Techniques for Root Canal Therapy: Nonsurgical Aseptic Technique and Surgical Aseptic Technique (Mentor, Dr. Bruce Paster)

4 Research Bulletin • May – June 2015 • Harvard School of Dental Medicine

BSDM PhD Graduates

laura Jacox, PhD, DMD 2016

DissertationRole of the Extreme

Anterior Domain Organizer in

Craniofacial Development

Advisor: Dr. Hazel Sive, MIT

Kai hu, DDs, PhD Dissertation

VEGF-Dependent Mechanisms Controlling

Osteoblast Differentiation and Bone Formation During Bone Repair

Advisor: Dr. Bjorn R. Olsen, HSDM

liang Ye, DDs, PhD

Dissertation The Role of Sorting Nexin

10 (Snx10) in Control of Osteoclast Function

and Regulation of Bone Homeostasis

Advisor: Dr. Ricardo Battaglino, The Forsyth Institute

Malcolm Whitman, PhD and Yefu Li, MD, PhD, Received U.S. Department of Defense Research Award

Malcolm Whitman, PhD, professor, and Yefu Li, MD, PhD, assistant professor of developmental biology, received funding from the U.S. Department of Defense for, “An Herbal Derivative as the Basis for a New Approach to Treat-

ing Post-Traumatic Osteoarthritis.” Co-Investigators on this project include Tracy Keller, PhD and Lin Xu, MD, PhD, in-structors in developmental biology.

Osteoarthritis (OA) is the most common cause of disability in adults, and the most common cause of disability among military service members who are removed from active duty for medical reasons. Post-traumatic osteoarthritis (PTOA) is a cause of disability in young adults who are exposed to traumatic joint damage, and is therefore a major concern for military personnel. OA is a painful disease that involves the progressive deterioration of joint structures such as cartilage that coats the end of bones. Progressive joint deterioration in OA is accompanied by cellular and biochemical changes that drive and mediate the tissue destruction. Whitman and Li believe that this “progressive phase” of the disease provides a good target for therapeutic intervention that ultimately will prevent joint damage.

The goal of this study is to develop and validate in an animal model of PTOA, a practical new class of therapeutics that targets the progressive phase of PTOA. Unlike existing treat-ments, these drugs are meant to arrest disease progression and prevent the onset of PTOA-related disability. This drug class is based on Halofuginone (HF), a compound that is derived from the active ingredient in an herbal remedy origi-nally used in Traditional Chinese Medicine. Whitman and Li recently solved HF’s therapeutic mechanism of action. Pre-liminary data from a mouse model of PTOA show that HF potently suppresses disease development. Data from cartilage cells and cells that make up the synovial joint lining show that HF and related compounds suppress the tissue destruc-tive program that is activated during the progressive phase of PTOA. Work on this project will expand these studies and provide the basis for developing this drug class for treatment of human PTOA in the near term.

Research Bulletin • May – June 2015 • Harvard School of Dental Medicine 5

Student Research Day 2015

An

ne-M

arie

For

d

Anne

-Mar

ie F

ord

An

ne-M

arie

For

d

Bjorn R. Olsen, MD, PhD, and Yingzi Yang, PhD, professors of developmental biology, reviewing student posters.

Henry Ohiomoba, DDS, MMSc (Orthodontics), discussing his poster with John Da Silva, DMD, MPH, associate professor of restorative dentistry and biomaterials sciences andvice dean of HSDM.

Shanele Williams, DDS, Received the Joseph L. Henry Oral Health

Shanele Williams, DDS, MPH 2016, received the The Jo-seph L. Henry Oral Health Program Award. Williams is a General Practice Resident at HSDM working at the Cambridge Health Alliance. She will

receive her MPH from the Harvard T.H. Chan School of Public Health in 2016. Williams, a dedicated public health and community service advocate, is currently the supervising dentist for the Boys and Girls Club of Boston. She is a clinic volunteer for the following organizations: ACTION (Action for Children and Teens in Oral Health Needs); the HSDM Wampanoag Oral Health Initiative; iSCAPE (Improve Special Care Access and Patient Equality); and, WIC (Women, Infants, and Children of Boston). She recently completed a study, “Using Pop-up Oral Health Clinics to Maximize Well Child Pediat-ric Visits,” under the mentorship of Sang Park, DDS, associate professor of restorative dentistry and biomaterials sciences.

“The Joseph L. Henry Oral Health Program is supported by the Dental Service of Massachu-setts/Delta Dental Plan through a cooperative agreement between the Office of Minority Health and Minority Faculty Development Program at Harvard Medical School. The Oral Health Program is an academic degree-granting program, designed to create oral health lead-ers, particularly minority oral health leaders, who will pursue careers in health policy, public health practice and academia. The program is intended to incorporate the critical skills taught in schools of public health, government, busi-ness, and dental medicine with supervised practicum, leadership forums, and seminar series conducted by leading scholars and nation-ally recognized leaders in minority health and public policy.” Retreived from http://www.mfdp.med.harvard.edu/oral_health.

Sung-Kiang Chuang, MD, DMD, associate professor of oral and maxillofacial surgery with Michael Sunwoo, DDS, MMSc (Orthodontics), and

(Prosthodontics).

Program Award

Hawazin ani, DDS, PhD, MMSc

El

6 Research Bulletin • May – June 2015 • Harvard School of Dental Medicine

A publication of the Office of Research

188 Longwood Avenue — Boston, MA 02115 www.hsdm.harvard.edu

Bjorn R. Olsen, MD, PhD, Dean for ResearchDawn M. DeCosta, Editor and Layout

Heather M. Denny, EditingLeanne “Jake” Jacobellis, Editing

For information regarding the Research Bulletin, please contact Dawn DeCosta at [email protected], or 617.432.1121.

HSDM Publications DEVELOPMENTAL BIOLOGY Abula K, Muneta T, Miyatake K, Yamada J, Matsukura Y, Inoue M, Sekiya I, Graf D, Economides A, Rosen V, Tsuji K. Elimination of BMP7 from the developing limb mesenchyme leads to articular cartilage degeneration and synovial inflam-mation with increased age. FEBS Letters 2015; Apr 15.

Alikhani M, Alyami B, Lee I, Almoammar S, Vongthongleur T, Alikhani M, Alansari S, Sangsuwon C, Chou M, Khoo E, Boskey A, Teixeira C. Saturation of the biological response to orthodontic forces and its effect on the rate of tooth movement. Orthodontics Craniofacial Research 2015;18 Suppl 1:8-17.

Anderson N, Jayaratne Y. Methodological challenges when performing a system-atic review. European Journal of Orthodontics 2015; Apr 6.

Andre P, Song H, Kim W, Kispert A, Yang Y. Wnt5a and Wnt11 regulate mam-malian anterior-posterior axis elongation. Development 2015; Mar 26.

Li Q, Doyran B, Gamer L, Lu X, Qin L, Ortiz C, Grodzinsky A, Rosen V, Han L. Biomechanical properties of murine meniscus surface via AFM-based nanoin-dentation. Journal of Biomechanics 2015; Mar 11.

Olsen BR, Brachvogel B. Thanks to all those who reviewed for Journal of Negative Results in Biomedicine in 2014. Negative Results in Biomedicine 2015;14(1):6.

ORal health POlicY, anD ePiDeMiOlOGYBenzian H, Greenspan J, Barrow J, Hutter J, Loomer P, Stauf N, Perry D. A com-petency matrix for global oral health. J Dental Education 2015;79(4):353-361.

Hebballi N, Ramoni R, Kalenderian E, Delattre V, Stewart D, Kent K, White J, Vaderhobli R, Walji M. The dangers of dental devices as reported in the Food and Drug Administration Manufacturer and User Facility Device Experience Data-base. Journal of the American Dental Association 2015;146(2):102-110.

Seymour B, Getman R, Saraf A, Zhang L, Kalenderian E. When advocacy obscures accuracy online: digital pandemics of public health misinformation through an antifluoride case study. Am J Public Health 2015;105(3):517-523.

ORAL AND MAxILLOFACIAL SURGERYAbramson Z, Susarla S, Lawler M, Choudhri A, Peacock Z. Geometry of anterior open bite correction. Craniofacial Surgery 2015; May 2.

Konopnicki S, Sharaf B, Resnick C, Patenaude A, Pogal-Sussman T, Hwang K, Abukawa H, Troulis M. Tissue-engineered bone with 3-dimensionally printed β-tricalcium phosphate and polycaprolactone scaffolds and early implantation: An in vivo pilot study in a porcine mandible model. Journal of Oral and Maxil-lofacial Surgery 2015;73(5):1016.e1-1016.e11.

Laviv A, Sadow P, Keith D. Pseudogout in the temporomandibular joint with imaging, arthroscopic, operative, and pathologic findings. Report of an unusual case. Journal of Oral and Maxillofacial Surgery 2015; Jan 13.

Pace C, Hwang K, Papadaki M, Troulis M. Sialadenitis without sialolithiasis treated by sialendoscopy. Journal of Oral and Maxillofacial Surgery 2015; Mar 18.

RESTORATIVE DENTISTRY AND BIOMATERIALS SCIENCESGil M, Kawai T, Ishikawa-Nagai S, Da Silva J, Nagai M. Identification of putative bone anabolic peptides targeting adherent plasma membrane. Biochemical Biophysical Research 2015; Feb 23.

Joda T, Gallucci G. The virtual patient in dental medicine. Clinical Oral Implants Research 2015;26(6):725-6.

Lee S, Betensky R, Gianneschi G, Gallucci G. Accuracy of digital versus conven-tional implant impressions. Clinical Oral Implants Research 2015;26(6):715-9.

Schnitman P, Hayashi C, Han R. Why guided when freehand is easier, quicker, and less costly? Oral Implantology 2014;40(6):670-8.

Shin J, Kinnunen T, Zarchy M, Da Silva J, Chang B, Wright R. Factors influencing dental students’ specialty choice: a survey of ten graduating classes at one institu-tion. J Dental Education 2015;79(4):369-377.

MULTI-DEPARTMENTFagin A, Howell T, Park S. Impact of the NBDE grading change on postgraduate admissions processes. J Dental Education 2015;79(4):362-328.

Giddon D, Donoff R, Guralnick W. Interprofessional collaboration: opportunity for dentists to reinvent themselves as oral physicians. California Dental Associa-tion 2015;43(2):63-4.

Kruse C, Nuutila K, Lee C, Kiwanuka E, Singh M, Caterson E, Eriksson E, So-rensen J. The external microenvironment of healing skin wounds. Wound Repair and Regeneration 2015; Apr 8.

Lowery J, Intini G, Gamer L, Lotinun S, Salazar V, Ote S, Cox K, Baron R, Rosen V. Loss of BMPR2 leads to high bone mass due to increased osteoblast activity. Cell Science 2015;128(7):1308-1315.

Park S, Howell H. Implementation of a flipped classroom educational model in a predoctoral dental course. J Dental Education 2015;79(5):563-70.

Park S, Howell H. Implementation of a patient-centered approach to clinical den-tal education: a five-year reflection. J Dental Education 2015;79(5):523-9.

ORAL MEDICINE, INFECTION, AND IMMUNITYBelstrøm D, Fiehn N, Nielsen C, Klepac-Ceraj V, Paster B, Twetman S, Holmstrup P. Differentiation of salivary bacterial profiles of subjects with periodontitis and dental caries. Oral Microbiology 2015;7:27429.

Duran-Pinedo A, Frias-Lopez J. Beyond microbial community composition: Functional activities of the oral microbiome in health and disease. Microbes and Infection 2015; Apr 7.

Lee C, Huang H, Sun T, Karimbux N. Impact of patient compliance on tooth loss during supportive periodontal therapy: A systematic review and meta-analysis. J Dental Research 2015; Mar 27.

McMillan R, Taylor J, Shephard M, Ahmed R, Carrozzo M, Setterfield J, Grando S, Mignogna M, Kuten-Shorrer M, Musbah T, Elia A, McGowan R, Kerr A, Greenberg M, Hodgson T, Sirois D. World workshop on oral medicine VI: A systematic review of the treatment of mucocutaneous pemphigus vulgaris.Oral Surg Oral Med Oral Pathol Oral Radiol 2015; Mar 9.

Motyl K, DeMambro V, Barlow D, Olshan D, Nagano K, Baron R, Rosen C, Houseknecht K. Propranolol attenuates risperidone-induced trabecular bone loss in female mice. Endocrinology 2015; Apr 8.

Ní Ríordáin R, Shirlaw P, Alajbeg I, Al Zamel G, Fung P, Yuan A, McCreary C, Stoopler E, De Rossi S, Lodi G, Greenberg M, Brennan M. World workshop on oral medicine VI: Patient-reported outcome measures and oral mucosal disease: current status and future direction. Oral Surg Oral Med Oral Pathol Oral Radiol 2015; Mar 17.

Shin N, Choi H, Neff L, Wu Y, Saito H, Ferguson S, De Camilli P, Baron R. Dy-namin and endocytosis are required for the fusion of osteoclasts and myoblasts. Journal of Cell Biology 2014; 13207(1):73-89. Sultan A, Stojanov I, Lerman M, Kabani S, Haber J, Freedman J, Woo S. Oral li-chen planus pemphigoides: a series of four cases. Oral Surg Oral Med Oral Pathol Oral Radiol 2015; Apr 13.

Taylor J, McMillan R, Shephard M, Setterfield J, Ahmed R, Carrozzo M, Grando S, Mignogna M, Kuten-Shorrer M, Musbah T, Elia A, McGowan R, Kerr A, Greenberg M, Hodgson T, Sirois D. World workshop on oral medicine VI: A systematic review of the treatment of mucous membrane pemphigoid.Oral Surg Oral Med Oral Pathol Oral Radiol 2015; Mar 11.

Ye L, Morse L, Zhang L, Sasaki H, Mills J, Odgren P, Sibbel G, Stanley J, Wong G, Zamarioli A, Battaglino R. Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption. PLoS Genetics 2015;11(3):e1005057.

Yost S, Duran-Pinedo A, Teles R, Krishnan K, Frias-Lopez J. Functional signa-tures of oral dysbiosis during periodontitis progression revealed by microbial metatranscriptome analysis. Genome Medicine 2015;7(1):27.

Yu V, Saez B, Cook C, Lotinun S, Pardo-Saganta A, Wang Y, Lymperi S, Ferraro F, Raaijmakers M, Wu J, Zhou L, Rajagopal J, Kronenberg H, Baron R, Scadden D. Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow. Experimental Medicine 2015; Apr 27.

Zhang M, Ferrigno O, Wang Z, Ohnishi M, Prunier C, Levy L, Razzaque M, Horne W, Romero D, Tzivion G, Colland F, Baron R, Atfi A. TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis. Cancer Cell 2015;13;27(4):547-560.