Clinical and Epidemiological Characteristics of Vitiligo at Different Ages: An Analysis of 571 Patients in Northwest China Jing-Zhan Zhang, Dong Luo, Cai-Xia An, Chen Xu, Ya-Nan Zhao, Jin-Xi Li, Shi-Rong Yu, De-Zhi Zhang, Xiao-Jing Kang ∗ Department of Dermatology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China. Abstract Objective: This study was performed to elucidate the clinical and epidemiological characteristics of vitiligo patients of different ages in Northwest China. Methods: We retrospectively reviewed the case records and questionnaires of all patients diagnosed with vitiligo, who visited People’s Hospital of Xinjiang Uygur Autonomous Region from May 2016 to December 2017. The clinical and epidemiological characteristics of these patients were analyzed by Pearson’s x 2 test and Fisher’s exact test. Results: In total, we collected data of 571 vitiligo patients with age of 32.9 ± 16.4 years. The prevalence of segmental vitiligo in children and adolescents 19 years old (24/175[13.7%]) was higher than that in adults aged from 20-59 years (23/370[6.2%]) and advanced patients aged ≥60 years (1/26[3.8%]) (P = 0.020). The prevalence of progressive vitiligo was higher in children and adolescents 19 years (72/175[41.1%]) and adults from 20–59 years (141/370[38.1%) than in patients ≥60 years (5/26[19.2%]) (P = 0.063). Children and adolescents 19 years with vitiligo had a higher rate of a family history of vitiligo (20/175[11.4%]) than adults (20/370[5.4%]) and advanced age (1/26[3.8%]) (P = 0.031). Conclusions: This study provides clinical evidence that vitiligo at different ages has different characteristics, mainly regarding an increased incidence of segmental vitiligo, a higher prevalence of atopic dermatitis and halo nevus, and a more common positive family history among children and adolescent patients. Keywords: vitiligo, age grouping, epidemiology, prevalence Introduction Vitiligo is a common acquired pigmented skin disease, not only places economic pressure on patients, but also seriously affects patients’ mental health and social activities. 1-2 Many studies have focused on the clinical features of vitiligo. 3–6 However, the clinical and epidemi- ological characteristics of vitiligo at different ages are limitedly studied especially in Northwest China. In the present study, we analyzed the general situation, clinical manifestations, and associated diseases of 571 patients with vitiligo, to further study the clinical and epidemiological characteristics of vitiligo in different age groups and provide a possible basis for early treatment of vitiligo. Materials and methods Study population Electronic and paper medical records were collected to identify patients diagnosed with vitiligo in the Department of Dermatology of the People’s Hospital of Xinjiang Uygur Autonomous Region from May 2016 to December 2017. Vitiligo was diagnosed according to family history, clinical manifestations, and Wood lamp or pathological examina- tion of the skin by experienced dermatologists. Vitiligo was broadly classified into segmental, nonsegmental, mixed, and unclassified disease according to the 2013 European guidelines for the management of vitiligo. 7 Unclassified vitiligo was diagnosed after a sufficient observation time (and, if necessary, further investigations, for example, history of trauma). ∗ Corresponding author: Dr. Xiao-Jing Kang, Department of Dermatology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China. E-mail: [email protected]. Conflicts of interest: The authors report no conflicts of interest. Copyright © 2019 Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences, and Chinese Medical Association, published by Wolters Kluwer, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC- ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. International Journal of Dermatology and Venereology (2019) 2:3 Received: 11 December 2018, Revised: 19 March 2019, Accepted: 13 April 2019 doi: 10.1097/JD9.0000000000000028 Brief Report International Journal of Dermatology and Venereology OPEN 165 © Chinese Medical Association Publishing House Downloaded from mednexus.org on [May 12, 2023]. For personal use only.
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