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Energy and Metabolism
Chapter 6
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Flow of Energy
• Thermodynamics– Branch of chemistry concerned with energy
changes
• Cells are governed by the laws of physics and chemistry
• Energy – capacity to do work– 2 states
1. Kinetic – energy of motion
2. Potential – stored energy
– Many forms – mechanical, heat, sound, electric current, light, or radioactivity
– Heat the most convenient way of measuring energy
• 1 calorie = heat required to raise 1 gram of water 1ºC
1. The substrate, sucrose, consists of glucose and fructose bonded together.
2. The substrate binds to the active site of the enzyme, forming an enzyme– substrate complex.
3. The binding of the substrate and enzyme places stress on the glucose– fructose bond, and the bond breaks.
4. Products arereleased, andthe enzyme isfree to bind othersubstrates.
BondGlucose
Fructose
Active site
Enzymesucrase
H2O
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• Enzymes may be suspended in the cytoplasm or attached to cell membranes and organelles
• Multienzyme complexes – subunits work together to form molecular machine– Product can be delivered easily to next
enzyme– Unwanted side reactions prevented– All reactions can be controlled as a unit
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Nonprotein enzymes
• Ribozymes• 1981 discovery that certain reactions
catalyzed in cells by RNA molecule itself1. 2 kinds
1. Intramolecular catalysis – catalyze reaction on RNA molecule itself
2. Intermolecular catalysis – RNA acts on another molecule
Enzyme function
• Rate of enzyme-catalyzed reaction depends on concentrations of substrate and enzyme
• Any chemical or physical condition that affects the enzyme’s three-dimensional shape can change rate– Optimum temperature– Optimum pH
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