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(eI qrdNac\€^rl[.rem orn. sgnGc"r. -truo. d.hnttrons thcr. rrrtrrpro:c ((^pC6\)ph1u_ \n "ft" pnvr6\r (l]\drrrsun I tncvtas[ rn s\"c * nq,,iii-riri -'-- t r tnttEa( {rrt aptgrrnaar 6q,goo or app,rrp nr{r brqrrr$<r aditrrtr,r,r hut. mtt.s,s qdhn"\ dtdqmd rtntun\ cnd nparr ce\\dN6\tn - n$c\h/ du.l$rn vS <ltro\asmrc drsrrn sqr(c{u5 n\drr DN\ {e,phUtgtoCteStn ttrdl6q /ruos[ oi.d o.of^r,!t\.s NrU, fr. poYor\sbs i rqrodNrtron Vta brnt\ hsston 6ilpL Ph,{t tGz) * 6cp (or at\ drrrsrun X sttrr{ af\ qrc,uttt cn{ A1P anp6dronstqt -S\tnt ( -tD(G\) + &rt($\s nD\l(6iL, mr\tsrrspirt\tt form J E*'*h**as c,r sB, ^^_*:i*l{ff*qk,'- o*t'..do'n* KJ ^[))-\{#ir,.gw|:"* 'Am= 'o"oga\.HffiHu*\m$',H*. E)"'?13frt#&ff"**" I W*.* ,a '/ltt\-..- J u,L+-nrrrm*tptr{w5. _lr.*^-, _ . . . ^. r.{h^t. _ Stru aJ r.brde [u1 p\odg\tvc\ \cr$o1\ , :":1 "l tl*:::: po\pod, mrrL,rhar\N6e_*s d$otd , tro s*s ct chonqsrrtts I J humcn so-a\c cag5 drp\ord , a3huo\oqorrs pt'trt , 4( (hcrosowrs , 14izr tnqot chorussrntr frffi$st P"\crt SF qc^.^cos trrptord ,23 *rs*ssrms :*ffi:ff* :S,htfi"lnt huno\qoq ctrrurnosorru : rysrrt,l +pdrrv.l 6iyuct,rral\y r6rntlc{ , n61 qq.c\r (r{tl \dh\k6'\ "p0""*, *: 7 a, - l[**S* 'f\/t n ]_."t^*'^..,- -jYl$(( sr?r. lsrrqlx, '-ArttcrtdatUrrr*Glh q@\o(i _ sPtm\, hutt, ttrinngaWtult ffiffiTJ j xl$'*"m"&*i,tersH"fl .-rtff'-.. rcffi;m-E;ffi,k\tso*-px,Qns 1th::$ a0\c\&. lntrulu& + cc\\ dtrsr$n csern\ 4:nrrs\tmrr$rbJts * nsnd\ltn! o\ts sarct *o tt tn tht G" phau S1n\trsu Phnlr CS) * \hA{q. Dr.tlr frpli&tb.l ' prtdw2rr5q1u5 66 png r) - U^ch chorrxopt rlr\n 2 sstrchrorwd,crr ' syrftusr tt huqt gotrhl ,( Non-drvrdrq tttls DNA cxu\s Os tr.s.\6rd ,GdnMidr h,. ' + chmv.\n 1 g\chnrqdl^ a{ hrnrrothorrr^tn NuCVo'r cnvtlspe tn'tart , n$&sNs pn!&tr toncr rptronrr\ rrctr.r, qru erpnsr\Yvppart ErSrru rr&tr\ o[ qtrc\,. tnhnatrrn ur dcruht^r ol\ - DtrtA nptir6.icA r^x\n hqh 6&urarr1, ur\tr cr$l c\tsaty!d,.1, (Pl(droft nq\\rrg - DNA npli(dtoo occ\tG brhn hWoc eswlq d,srypr^s , nd prtor .0rvr&nq (t\ls gt\q q1,3rt bd hqnfj t,nArru.tr (trrm : Chnrrnsorxs ) (Srre qru,(t dqG001'on .o\ !. o\ {st\ UNA tnt6 av.ltfrt!. trl\ N$clu( e-rNctrpe dsrnt(rat<\ ) - nucVs\s atlr,rt travscrrptunr.\l J lnac\r( PGtl(o s)n\tstJ tmPo@tt3 crsPattu\ htltt\ coin,nr,c\ r $snrs rnt cra(srbl4 +o tGsoqPtro' m6$ nQ3 pa(nt6\ DNhto bc c. tr,rnpril {o Astrrh*trr gh qv,rtc rrv^tsnl -po\ar sg extnl tourra E\fNtor thrttOh(rtc sfrorun(ott{t,*tr\ of Ctrnnswts of rnr'x srstu chitrndntr ar\ c<,rtowrq cltrrlrrsrU\t t{t(rd{s p'\srtrolcJLai opp6\t pile! K\nt\uthoa SF atkh\ kmrtochc,r. * rmtc",zu tU,riW*.*, T$pt p! chmrnsortrr ct(ondclrt on( un(o\\ ""ii"r"i ^t ngrVrv ecvt\op< rc{nn sP\tu\\r t\b(5 d.'sc&unl& chtnc,* m(^! fQ\&{'( dnrcmosow, No parnrS Po\o(st r\ot cflxilG\,Ytq,$h ct ou<,bqo,r aq.a^r. hvoggprl. qq,r*r-g\ dqn sqty 5f mtapMs Nu&orrvlw dutn& of spnA\t lrtns rotln - t\wmr\n 6Mrsrs*t CAgudr) 4n ErrSunqur\dstrrbrfuu { f\[lror b{{AlF darqrfu al\s Shared by Benjamin Ng On owlcove.sg
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Page 1: Cells, Dna, Genomics

(eI qrdNac\€^rl[.rem

orn. sgnGc"r.

-truo. d.hnttrons

thcr. rrrtrrpro:c

((^pC6\)ph1u_

\n "ft" pnvr6\r (l]\drrrsun

I tncvtas[ rn s\"c* nq,,iii-riri -'-- tr tnttEa( {rrt aptgrrnaar 6q,goo

or app,rrp nr{r brqrrr$<r aditrrtr,r,r

hut. mtt.s,s

qdhn"\ dtdqmd rtntun\ cnd nparr

ce\\dN6\tn - n$c\h/ du.l$rn vS <ltro\asmrc drsrrnsqr(c{u5 n\drr DN\ {e,phUtgtoCteStnttrdl6q /ruos[ oi.d o.of^r,!t\.s

NrU, fr. poYor\sbs i rqrodNrtron

Vta brnt\ hsston

6ilpL Ph,{t tGz)* 6cp (or at\ drrrsrun

X sttrr{ af\ qrc,uttt cn{ A1P anp6dronstqt-S\tnt ( -tD(G\)

+ &rt($\s nD\l(6iL,mr\tsrrspirt\tt form

J E*'*h**as c,r sB, ^^_*:i*l{ff*qk,'- o*t'..do'n*

KJ ^[))-\{#ir,.gw|:"*'Am= 'o"oga\.HffiHu*\m$',H*. E)"'?13frt#&ff"**"

I W*.* ,a '/ltt\-..- J u,L+-nrrrm*tptr{w5._lr.*^-, _ . . . ^. r.{h^t. _ Stru aJ r.brde [u1

p\odg\tvc\ \cr$o1\

, :":1 "l tl*:::: po\pod, mrrL,rhar\N6e_*sd$otd , tro s*s ct chonqsrrtts I J

humcn so-a\c cag5 drp\ord , a3huo\oqorrs pt'trt , 4( (hcrosowrs , 14izr tnqot chorussrntr frffi$st P"\crt SF

qc^.^cos trrptord ,23 *rs*ssrms :*ffi:ff* :S,htfi"lnthuno\qoq ctrrurnosorru : rysrrt,l +pdrrv.l 6iyuct,rral\y r6rntlc{ , n61 qq.c\r (r{tl \dh\k6'\ "p0""*, *: 7 a, -

l[**S*'f\/t n ]_."t^*'^..,- -jYl$(( sr?r. lsrrqlx, '-ArttcrtdatUrrr*Glh q@\o(i _ sPtm\, hutt, ttrinngaWtult

ffiffiTJ j xl$'*"m"&*i,tersH"fl .-rtff'-.. rcffi;m-E;ffi,k\tso*-px,Qns

1th::$

a0\c\&. lntrulu& + cc\\ dtrsr$n csern\ 4:nrrs\tmrr$rbJts

* nsnd\ltn! o\ts sarct *o tt tn tht G" phau

S1n\trsu Phnlr CS)

* \hA{q. Dr.tlr frpli&tb.l' prtdw2rr5q1u5 66 png r)- U^ch chorrxopt rlr\n

2 sstrchrorwd,crr' syrftusr tt huqt gotrhl

,(

Non-drvrdrq tttlsDNA cxu\s Os tr.s.\6rd ,GdnMidr h,.' + chmv.\n 1 g\chnrqdl^ a{ hrnrrothorrr^tn

NuCVo'r cnvtlspe tn'tart ,

n$&sNs pn!&trtoncr rptronrr\ rrctr.r,

qru erpnsr\Yvppart

ErSrru rr&tr\ o[ qtrc\,. tnhnatrrn ur dcruht^r ol\- DtrtA nptir6.icA r^x\n hqh 6&urarr1, ur\tr cr$l c\tsaty!d,.1, (Pl(droft nq\\rrg- DNA npli(dtoo occ\tG brhn hWoc eswlq d,srypr^s ,

nd prtor

.0rvr&nq (t\lsgt\q q1,3rt bd hqnfj t,nArru.tr (trrm : Chnrrnsorxs) (Srre qru,(t dqG001'on .o\

!. o\ {st\ UNA tnt6 av.ltfrt!. trl\N$clu( e-rNctrpe dsrnt(rat<\ ) -

nucVs\s atlr,rttravscrrptunr.\l J lnac\r(

PGtl(o s)n\tstJ tmPo@tt3 crsPattu\

htltt\ coin,nr,c\ r $snrs rnt cra(srbl4 +o tGsoqPtro' m6$ nQ3

pa(nt6\ DNhto bc c. tr,rnpril{o Astrrh*trr gh qv,rtc rrv^tsnl

-po\ar sg extnl tourra E\fNtor

thrttOh(rtc

sfrorun(ott{t,*tr\ of Ctrnnswts of rnr'x

srstu chitrndntr ar\ c<,rtowrq cltrrlrrsrU\tt{t(rd{s p'\srtrolcJLai opp6\t pile!K\nt\uthoa SF atkh\ kmrtochc,r. * rmtc",zu tU,riW*.*,

T$pt p!chmrnsortrr ct(ondclrt on( un(o\\

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- t\wmr\n 6Mrsrs*t

CAgudr)4n ErrSunqur\dstrrbrfuu { f\[lror b{{AlF darqrfu al\s

Shared by Benjamin NgOn owlcove.sg

Page 2: Cells, Dna, Genomics

{oo..tu5 g1o1q*"6 | splrt\q c\at1lrtv .r[s qgrt , nt\ oqwul\o wrn\y drsrrrbsur\ r.* poVs , pr{ur 2 {oc\rca\t1 tt{tiLd tr\\s

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+ fur tv6orA {rr\ tdtlnor rdrt(tca.\A,a*,1t*11 6911

Shared by Benjamin NgOn owlcove.sg

Page 3: Cells, Dna, Genomics

Cell and Nuclear Division Notes

Animal and Plant Cellsof Mitosis in

Centrioles Present Centrioles Absent

Astral Spindle Fibers Present Astral Spindle Fibers Absent

Cytokinesis occurs via formation of cleavage furrow Cytokinesis occurs via formation of a cell plate bycoalescence of vesicles

Mitosis occurs throughout the body Mitosis only occurs in meristematic tissue, localized

regions of active cell division in the shoot and rootmeristem

of Mitosis and Meiosis

Prophase Homologues unpairedNo chiasmata formationNo crossing over

Homologues pair up to form bivalentsChiasmata formationCrossing Over occurs

Metaphase Pairs of chromatids line up at metaphase plate Pairs of chromosomes line up at metaphase plate

Anaphase Centromeres divideSister chromatids separateSeparating chromatids genetically identitcal

Centromeres do not divideHomologous Chromosomes separateSeparating chromosomes not genetically identical

Telophase Same number of chromosomes in daughter cellsas parent cellsBoth homologous chromosomes present in eachdaughter cell

Half the number ofphromosomes prcsent indaughter cellsOne of each pair of homologues present in each

daughter cell

Occurrence May occur in haploid, diploid or polyploid cellsOccurs in the formation of somatic cells, somespores and during formation of gametes in plants

Only occurs in diploid or polyploid cellsOccurs in the formation of most spores and theformation of gametes

Similarhies Mechanisms by which chromosomes and cell organelles replicate and are maneuvered wrthin the cell

prior and during cell division is similarMechanisms of the processes of nuclear and cytoplasmic division is similar

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Page 4: Cells, Dna, Genomics

Cell and Nuclear Division Notes

Significance of Mitosis- Genetic Stability

- Daughter cells same no. of chromosomes a parent cells

- Same Hereditary lnformation- Daugl"rter cells genetically identical to parent cells, with no variation

- Gen&ic stabil{ within the populations of cells derived from parent cells, as all cells produced by mitosis are

clones ofeach other- Growth, Repair and Regeneration

Mitosis is the only way to increase no. of cells (increase no. of cells - hyperplasia)

- New cells identical to existing cells, thus c:rn carry out the same function

- Damaged cells in body must be replaced by exact copies

- Regeneration of body parts (eg. Starfish) is by Mhosis

- Asexual Reproduction- lnvolves mitotic division of cells to derive genetically identical oflspring

- Meiosis not involved- e.g.Vegetative ProPagation

- Restores Sur[ace Area toVolume Ratio in Cells

- When a cell enlarges, volume increases faster than surface area

- Upon hrtting critical ratio, cell divides- [ sukace are to volume ratio is too small, exchange of substances across membranes would be too

slow- Mitotic division would restore the ratio, maintaining optimum size forthe cell to survive

Significance of Meiosis- Sexual Reproduction (Production of gametes)

- Meiosis allows ior production-of cells with half the number of chromosomes, else chromosome number will

double for each generation- Stabilizes and maintains a constant chromosome number in every generation

- GeneticVariation- Provides opportunities for new combinations of alleles

- Genetic variation in genotype and phenotype in offspring prcduced by fusion of gametes

- Achieved by (details see handwritten notes)- Crossing Orer (ProPhase l)

Synapsis allow for crossing overFormation of new combinations of alleles

- Phosphoester linkages broken at interyenic regions

- This breakage of linked genes occurs simultaneously on patemal and matemal

homologues- Reattachment of segment of chromatid from the non-sister chromatid

- lndependentAssortment(Metaphasel)Orientation of bivalents is random50% chance dauglrter will get a patemal chromosome/matemal chromosomeOrientation of bivalents are independera of each other- Random assortment of patemal and matemal chromosomes between daughter cells

- Random FertilizationRandom fertilization of different combinations of gametes in nature also adds to genetic

variation of a rygote formed

Shared by Benjamin NgOn owlcove.sg

Page 5: Cells, Dna, Genomics

CrLLtuAt fuuc'rrous - Cqrbo\:)c\ratcs

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Page 17: Cells, Dna, Genomics

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Sqni -cq'D?Ya\t\,8 mtch&nkmNrrN DNA mt\tts\rs hGrt ort pnnnt'\ stranA a'c\ohr rl(N\S sgnrrhsurd &rttt/ str,{ .

Xrn6c\s6n - Stah\ Fxpvrrwr\crk,'. Paftr\&\ oNA Lc$d\d \^rth'rN

E.6\i c\Nnd fu qanatrons tn q.".rA'rm t'rfln t'Nlncorpu,&.or bFSN rn\o \lt nsdr\ir(te5

tr^s : tronst<nnq t fxlk4 E.6\i +o o.mrirrrn r.11nh hNC$\\)ed istth trght ntVqrr

{lnt r Br\racion oF O*n 6oc,r E 6\i tw qatr aar<rdrun ')

*p6rrd DNq L* ehq ont qu(,tro/l 4 qorln ({6ft( t\o qu<,rdru 4 qowrCn .|

4. DttlA Rt$tutttm - Ttr prrc:

]0.r,<*.,4

Natson -Cr,t\<\ hr1 po\tu5 rs

-tr.rapanntd s\rardr se*ric bq bnakr"n H'loon/s- l1h:Jqlo$s t s.+thgdc ftr syrr\hrlL of rrtu,r pr\nrc\rshdcchc{o- enzJflt Lnk tc trsc\qr\rd,ts

) 2 r&n\rrJ rn5\1a\6 of ONA

t23(rstq, Att

oN Jrrntrwdt^tt->oNA ce\t.vl oe

'sNst.t,tf ,hdoflqN sta'd

d,s\nqrsrr Dt\A dos56 - dusv CNA sp" Au^n $< tubc

llft:\ltl* - \qht< bt'A ctosqr\trt{oP

Ctntn5n.L*

-*dffis,tp<rarlc rrM sirark a* lhc,onqtn d'r@\i coC[uro' ?npltra\on bnbb\t:--+ar-____J

0A\ lptcrhc huckc\rdr s6{(^rrA'l rvh (us nrph.,c\a^.robrukbs^a)

- cddn c^d of bubb\ forms np\rrtron 6rk ----------+- rc[\rto*ron x brdrrrrhuq\ tb6lh dr(ct$ns)

Pltkalsins Ertkcqct:S\nq\r OBI il\\\rolt 6R1s

" ffr6rynilttrd,q.ur*:/br$ttrs

\n'. seatron 4 nAsinnA-tus. orr urrrmdrr\tnt d,{pkx

[{1a51 brrd 66 moltc a\u/ulh$ra^dbrcok. H ktrvl.s rn Pn5+te ol'JA1P

'.pa(ztt pa(/It s'lrznd!

\'n *rs S\cior\r<c- S\nl\ts\rrrnd JS:raq\c sftrtn(tA. Brndtnl pruurns

Df t r'cak rt-Onnr rr\rnor -'P^td( %DNN 6\,i a"1..,tt*^ tnnr nuc\<ckt

{"s.tnrrr. n[g1st6gr>n frtrr uvrr,lnAqlnu\r<\ ahtaA { frt h"k+opEomr@sd $'z,Stg crtrfu -\rorirttt sv.1|e stro^il(( n(k0\\orro srqn(r{ 4uncril Asd.x bNtr +o sort/t\wxnA 1n{att straru\, hxfarl rt-s(a\t1gj

ihttt'. Drrmv.,uttA p$st .,",n-;;;rlffsuilrhts,5 dt nlvo- can on\ stact fum prt<xsh\ B6t1 <ac\

A Porhon o[ un'qo\^A partn{ DNA servr e.t trmD\atq6r pnrrr-r (trna\o ioAyr omuoo*ac^x b6t( 6.ou^(

- KNA pnnret Gru\ysts \qh1g'ot i o",Frrlr Prrnr.G( cv\rs(s JQh\l5ot J pfip..oun."\rtbonsdta'\t\r r -ts (04fi(v({ RNA pnrntr I "' 't*-' -'

- pn$de 5 fnr :'$lcnA {tv( fr$ pO\mq'a5r. con erctnc\- cvtt$€.\\ q$atd. B DNA I

{u.nr grdtvs,, d da.roiltv.r S\rrzt\bastd on t*rplrt"rrl^l@ tht s\rvtd, rss{,rULi nqdr$fu 5

DNA P\\T(lase t,\{&s vl 6. 5' ts 3' }rrc'rrour cn\I dN\P \s:rr pyophrsghdumc\rr"\r 1.*qI ftttn *rssoh. csttr btru{ *rn 3'ttl arA SbhosPYr<tt / 'II {(((I\ *\\sph..sttr btrut *rn 3'ttl arA S'ohsp}rctt /.

0^qn*"' Utli s ry6Vrs rzrA ln oPPos${ d\ct^'rrtr, Sm\ d.sbr(rn"qu

LeAprsG3tnnug

lA(rGvlGqq$D

{r6plUn r: exg66ad 3r +65;'. ctft\lo\oArstoucras np\t t n\rrn (urk

srvilt B$A prmrrrr<c{dsyndusrzd'al 1 po)*.,."\d.

f,sftrovrt ttzqthcrjovd Grsyiwrs

.a.

dtsrsrtrnort<xn\Wsr".d or chod t(}qr\ntsi' *o J ,crqavrst a,atton- 4 tork

-- fs*fOrdvl-'-z 6.^s (',s\ ofrz.ki kqrnur\-2 6rms Prrsu -

.L

- zfltt[* {sdwsvru'n}.,n1

al,

0tYxfl nmsvua lNNtgasr' v.a - fornr phsV\rt\rcJtq^ lEvt\r

6tmudra*,np\aa{ -----> Uot* &,q*v*Sb0 ct\N

- P + dqN)nsaqnitr{( crd ttrm nuDNA

-c+RtrlOftruvprrpnmqfDNhprym<alt h[ S"P

5. E.Jdnvb'rn^\n vs

- lour\u oad<d- \.s dn'd,nyA-Loopd doo.ans

- S\A \ansono\wY.\\s ac\sr.

- Ftdcanrtdcj r n O\ L{^bb\rctrtgar{ut cdts

+Cft{tvh 4etC rxpftls,rMl

HtltoQrrowrct\n- \t\\r bo<h{- h,qtr\-v 'tot &,"1lr\- rrcio\rl ci\txr pralons

->rrtrt 6rvad tb\hrq- 1n'rsctrphorv^lll trvit\rt- twrtuVrl^c\ rir adyonr(g

tr.d -\t\omrn"- dus r*f *ort- u,rdtrs,<d +hro.q\b.A \tte

lvd( 4 (dl

Shared by Benjamin NgOn owlcove.sg

Shared by Benjamin NgOn owlcove.sg

Page 18: Cells, Dna, Genomics

qENE E&tEssroN. T}lt\'(&\NoN t.I?.ANSLA1ITN (EU$R\0rEj) W ll

t. The C,r*r*." *a"i4au ft nrrues ( rue t9dst6 ad&

,"I^pte+ code

- ekh uRttA odr{r^*$tsea on srrnnt nu{ m0til\w\de dr.rwr ool(rslrtt 3 00lAE{^1\,s

N{cotda bfr$s-ftc\ q 43"M odons

- sttyt cod$,\: AUer (d\rt 6{15 gy bQ]|}l\oh$e)

- $N! odons: uqA, hAA,ulq

I.CoAStrc ou{e tS hl$,oSt Ur\\wrso,t

- Sfti0 t{do\ q,e(lfiel)fu +\t 80\ I\s O.[r.lrl0 o.dd

Ir\ ft^q u{qtr(te(

3. Gustro ailo ( de$lcYoqo

- onq I onwroqutt sYt 00deAfuV\q'st$+ct0d$\

!dlq-r\eih\ot\\1Aa UtU -tqptphavr

- h\0$ 0\III\A\1^,! ltq(s 0irs odd {r Ulrt,uvc tunurc radovt

- 0$ctrr codon 0q audes oropwtrcular ar*w ru{

4" CoQttr, o(e rs av*{v\\rol^S qMd !16$-6,AMttFx{

-etq* &lfon d$nu ttro veadwq{vurne {rmM-e[0\0dp{r^1 haot$ rp[d al o,t\tt r$ilr,

g*St4rwchsvr

- no eh?t\ t t rrutteohdcr

s. U{dd0\0 SIO $rtxowr{,novr oq,u0rg

- htgroilf{r\$ 0.rrds aros^rs{sd. 4dqell€vofeoAsv\s *foruq rvr {he, },{ psttrtrt {b[ro

- ll\ s0r^Ag ctrttg, 0t s\t\$e IQNA cqn rcuoqNrr

.I6Y twtc of $^ut 4q$^{Yd, ordMs

&alrt7to, pha'.q\aratrv!9 *.Nih h\!it avfi oJdt!4

U- Alr.:a.-E, i+r{al*i g_i Uorl/_r

d-u(0-, t s'_uur^-3

- \,b\q\$\^ ( USU't^lbnSe-porvrtnq vrrrle.s ut 3rdr

hwtrcltilg ut r ^uorr

tg cet\eA 'woloblcn

- fieuqo \vt ?rr4b0.A ( O,ootorrqur,rfUfwrrvol

St\\ prut enwe*Noytoffirrnot n $uuno{iir.$\o q$d r\ 0\ !$t$h

(q{cr{trrutffi0u)

1. -ltrwrgortlhtvt

+'liefro*:* \ \"rhd!\ [ co'tt$lx,t*,rari RNA m$er,ta\e rc

h^o.AS twJ| e ti4$t{c re4i,,u,1 q tue. DNn h,ri\e$*{.

+ RNA s,qtie$e$ rn$h{ UrA e.r tr&pia.io

# Ts,r,rfltts slvnvd (q DNA)

-lvunsrribd I wdr,vq stlut(- c{u,q\g$r0ht{hl1! RNA qB$^.6-

t'lm-tu,tltote sttmaa

- h\rn-ta.t{scv1b€{ I norrodir,g ein'^4* ek0.0t eau\4 scqra^@fls Rt{Ar exqt $qh{ue, rr1

h.t& q\SEd wltl,r uaul ir.. RNA

iiihrltffe t h q04s

+segruurft o( tr\lA v{t$A tlv\qte. hutleoade lkftro s{quu^.sthot c4es W a. \r^v.ibilo./ RNft hokur.\e I poqpHi6g d.altl

lx*iote,v CoJ,,,q y%rrv1 &vf,ipl6t.rt qt.

- SEr^o^.s ,{ t*.\A-tl44r E l'vhhErf1k* i\It\ E\A

- qu*tce ryoifl$ ard {rtorsrytrun

+'tsq!\fi0 $lrtlird + oo{rq rt4w* hrtrxya,

!^pti*, lg tf$$,!er'ot4

l.le'rtq}!q\&te S*-n!1d s prxrttv, -ft'IA

iq, st,

"{pTltft11u ard " rhwh*re*$rofire drdlq Yddloliti {ttf,,:lt +f *wr$*'eo1$et8/oq M t'ai E,clp tl*h{

h$t'lnttutrun

l- 5 Stova\ lbtrat *unqonvfron {aoors (p$otuns) to,rrd

t phurtei/ tqu\r. Rt{A ttt\iAarNr, rt o$nil^Uq qt yx!ilfiertl lwwl

{mnrsonpon $ll\dlil^ c/olt\isr

6. NA ttubtc-l*rx rrrrvu,tdt {uo tq rVO htdrhq,nan$rlpltru

h$nc ft sl0irtstte0rrtn'^$6a $t[hd

4. +1y$ I nlfi\rrilo0$de {n$$phtrt{3 l0lhtd ttlhu/ ilffwth

{ommtn "[ ptrolptocto Wa ddpr{ \ nA fl\rucnc I

xq J6r,*n qc+g

Rl\Asfl\uq- mtto\^s iltt0E$l(d bCt*t^{sx0t^(

- t€t$S^$ ( bilrA rad\t^.ttw$$pFaO,a r,ut

cd^tt{\rOtS

- Fc-lf,ll.lA Wd$r8@s c$rtr.to4tu cnrto ruatrrre,

lwrtttur,\ nRI.$

- rtrttmvts, cys ror.r0vod, rx0Not 91,[email protected]$lt^gy

bg sp\ensoruee

l, *to*nq r? ftNnnl srrb,ilrttr of srrlNps

1 latan\\ v\uct{0lr nvronr.\chnp,$eWl

l+ aadn ortNp corttrrns rnRtiA UAfoUras-q\eosome gUhur$s hhA 1u eltrqtlo sequ{ {caa,

oil.rhtq tnto^ h trnp otthJoyd t0 $y$ aPNA \qil$f

- $t!l! ors lowulv* qot& \iei{^ov, loolh*tre

B' amAC gflrp, gtot otcu^t, Qrov\e aileqival{t{r\ qfff,d,^oi

- tv\Aq\A rq RlC0r0il u,trdrUrO,maEd,eqvnao{

- \dm\rs of ftt?

4.TY0tlv\stq\$-\hjo r?lothkhf\ rV,fE r

l. Cowcct wrt\*r !:fiw *Rlt( 0r\d 0trr,T . : tu.ril

:. sYvort irt+srr,[r niurn]. tslA ort\ruodqn. (lt1i

*rRt{At-o{orn

+ po\rlyEtrdo 0{^0(,?1 cr",!l1hgtr( l,1!l!rt!,r.sRh 0,{

ts*?\c{e

Tn{\St{hr PNA

- c\wtlv\enf :D I ero$dqx{st\,.cture,

L-$^q$d, 3!l to{t{0.Y\,i s\rci^vs (t'{awrde)

- 0Nm(0v\ + brvdstD \ts q?s4rc covrltct^s^\oq

rrrRNA r.odwt vt^ rduqle,Mq^1il,r{ !a&-[nuru1

- 3, CCA s^d, + n{tud^ r,i\aat tr syu(rc ourro o{,r4

S,tnthtw,- W\roC AS mr a{nyw &nighlg ry\ 1vA}{s\3jrsr^r{

hrCNff n*diqsi{, YVt^Ntu iNr arrr,o Atr,i

*{*.arce 4 fo\tp€?n(? oteiq

- tt{tilS?ry1l frr,,ii\0 afid( rh tqi0lir.f'li $ rrhg*rgi

1,v grqlopt a* qntre,ors

?*heor,^es

- J Slbun\B, endn mrrtntvrruS rxM otrt/ryntuns

- st$q\\ $br,.r\t (+os) +budrnn srle SrvrtN[- lovqe subunrt 6oela t hsdrtqertotktRNA

r' hFdt\'$sl[ettc (Ps\rs)r +8$lA c^ynltqilc $10"rrr,6 I*h{WFde el^4rvr

1' {nnmoc$-iilriA srk, tA s1B)+tRM'mrluq h$ft o,rrrrr$ ouA*o rro ddel

a-txt+ stte (t j$e,)

)drsol^qv{d tFNA r \enus {Ug y\b&ytr0

Srv',rut[wtoW tvaraglo*roY1

- 3t&&v*l rihaioit\4J cdr,1 *{t4ilCttis $vwl eue i+'ltlq

4t- t\e Sfiir,rf fl$,\a, regirhllt\n Stq]q4 frir]r1

fr.{ f\$[s6ya04

- csd&r.!g flUr,scf,Iltl1sra'"i pr,96le tte O'rA

e,$6adg rel}o$l,i"iie1b.f.r{,'t*wq*.

- ]i{T tlTrnti,r,ire'*

- {6i6\r1( -,diA v]i]. its b?

uqs11€ab1.fo&tky sti

{rt' h"rd.'*q S" Ai{ue'*t- d:ial*tlrrner t!ir.o,rt4 {rl

i.s$*.1-.dr d !*qrt $rtri(;,r I'ti,lliiir* Srrn"i

* gustwe\ Xo,rec- oirado a,ntuto 6ctd s{4ut^ttc, t\tYt/\s ttR{A

- tto\S0riloa4 \ RNA Ft{r.troso ll

liorr-ttu5rr1ta1 8u,teS- trot 'rrult\sldlod, 0!ge tr Y+Nfi, tRN[, $A]dA

-1v4ns0Y\loQd \ RM go\usnso I

Stqe rr €\ou6ftiNv\

t.nNA poqi\sr06{, t{wes d0uq1e&{$&t0 ol,l A $YryS, w$v$3tg

o1tllta1g lrdi$, $,t(c' +\,trttlollrftv\\lrbblC'

:. Tun$6o srrrnd rlted us t{$^$otstrr mNi Pduq*,RNA fdh1rsereEo

[ 6dd-x +s, nbrtrt,icterttile5 rn nuft.oghlmt

1D fiR 3'q^A 4 t or,lrn{ BNi $otoq^te h{ c$lr1lstno{b$l

MP-?"",nt

3' Tr0t\cs^\5lth^la*huroyq^i,r1^)ard\\ E + d dl4*rsvt,

ptryuwned qortrtu. o{ RNI Yr,o\Qrilto dtStlt'/rdot tvtr4^

bNA- tr[o^rg t]v sttltlitlgtl\qsw tqr\(\,vrftt\04 d hq1+

slYo11d at ill}tA

4. St0r60^ DNh stuMs hh$^a tt0it\gt'r Phttriililetet\^Yh trJ {outdo-hel\x stn&t\^,tg

:

S\qqe t' '[wln^\h&ho^

I . TyonscnP(g\A ltwtes*s u.lltl ofrw lllAF\\'t^em.te dtolN)Alel

a tsw\MoJh0v t{trqM0&, c^dt' 5tv a ?\aAen$t$tonsr0v,Al tt\ ?tshrBNAlYonsllYt

(AAUAM)

1- RlrA 1itr$S0frF /prcrnnArC amued &ryo$c w{{hg $ybvr$^{

INA d^0t'1, 10'15 bP d0$n$Y00s\4

Yo\qdo\\(t1sn srq[d 41uq^(e, ]r\4 yloiu$ Nhld^

o\j10il0t0 h$n ?,knNalos\t0 oild tr{t {kQ, RNA lrav\scnpl

{to {wwr?tt{ P\urmsc

3. hgt- ltqnsonPh$na\ Mu{$cntbn / $lA hntesqr!\rt

5'eaYPtn{

- 0qws w!*\Q- frewr$lth3 s1\\ hrhttyor/rs0\nb00\, us$q,t\Nh0l tY0tr\Sort$ ts o!-lE nteleshdoa wt tq,qU"

- 1 - rnt\X\6rronm\ho l\/\o\eurlg

*,uicnuurg:

l. nouoqvttsA{ \uq-hndr'ir1 lrilutqrc Nhrei,r avevreedd

*o. -Fotsn extt { tr,t'}.}lA{wwttrur.\tng

- trrdtqt vrboguho trlrahstr{trtih

r. I\mtects lfl\RfiA$,tw\ Aeq$dr+'wr \ rrutlonse-r o.rd,

fosphfrtfiscs &tnuq ttrt $ulrn v\ud$,$ t0 n{to

1'ara

d po\odu$o*rrvr- td! (Al *ar\ odtad'urtanrrdd,lvl 3s^e 4try(a^c{, lo^f tg

ad.Ied q^a$^r\rM4w{ 4(r{^/ fre1'4RNA l( 1!0}1s0nb0il

- s1tu,q ( u{Mne nnotr.otr4% 0$ 6r &\d, t00-)t0

hrde$dla\n \e^,ql-

Sncu'o*g'

l. Prqi€d(.jr$$A $,"d.vt( dqvadattor' \ h'1&o\qY{'"lrv'v*ea

r. NtSld. ftv Ytt!0v CIxt sl $irNhtdi4 11rt\0t{S

s. 6t{Vir\r€S mPJ'iA {trryv,olslh ftv*kerts

ort

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Page 19: Cells, Dna, Genomics

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t. Arttnonotl-t$lA-sgrthetare cil\a{tt,te lt$\s firr{ho nf,dst$ cowqt SNAtedn anrupao{f tlNA-*thfio*hce, on\ }fr a g}qrffc o$rhluqwr of ortlrno octo\

orrtt tRM Nfi a pffiulor oftHt^t4ovr)

t. C0\,e\qfito\todl/$v\qft lc6!d. qr^\\o turd-t omA t$\4 catt$gt hrlh*t^ohu&,t\ns { 41}

3. R[$\iu( omrnoncrtr\ ilNA \<rsleogs{

Stano r' lnrttoiflwl

i oo\.y€S ,,rn*oh uetwet,rv\ -bltih a*tttWdo{ qlvd h&NA codrvt

t. Swot\ nh(ovi.ril Bulourr$ tands ft bcnt^ UIRNA oud A glr€atD il$ofi\tr

i[NA cAwlu{ r',retl,rtvnrue

r. Shrq\\ gulount etqns do$n$veNu q\$Aq mRl\A ramtrl l+ Yeo0ka gtort 0odon

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4. lnfio\tw$NA lrurs tt-bous oqlngqvlac4ov\

E. rrrhllA, lyllhctm tN{A, ot\A $tdl rrbtgouut gubuntt tc ntA$toil {qe'ttrov

$ h"rl0 hh0c0uil.4l sllbuNt ru {run a rmn$ortt0h t[ttofito4 o$aPls(

G.lnt\\ntr tRt{A nov! ln P stt { hboi$^e' vaca}t+ A $e

1. {i5dvdqns of 61P ttruolud\ (uwgt1)

gto.qo 3: S,ogofiun { tqvrStocnt ovl

+ ^l{[\Er

acdg aad.ei t" {-ta.!(,rrual ( trs€d$^{ 644^tt^n oted. uta {lo.?tde b.r{l

fuwro*rwr

srcF l' Codo\ rerc6nthot'l

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lrRNt odstt lYr tho A stts

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step r, ftrytdo hu{ fuilotrwr telr.rtolal,r$oaa4r^ctc axd e.lt}$dcct^fit1

- hpttdqtrmwft,mse )€h^rvo&P.qtthdl,t*l {RMN\P s$q (not^ra

&0.0tu14*0il tRNA) , tnrrSFr( tt 1o ths A$tno lud, htrh{ t0 rhO n}.i)

mfidI\ thNA rrr A s$c

- to*\ccs fwu4r$v1og Ffdsruordgtep 8: Tvam6(gg6gxy1

- Rrboeoug (llt/td\ br,RNAu 0!0 hl(l{,'Jg 1s eAil4 otl^$r h4 ot\o 'odilm thg

E'+ tt 4rwd\r / niroSss^e f$$l0uto b1 nrre o{ovt

- DQsaqterd till.tA thtts{ t{$^ P $P t0 E me {r wtme

- lqfidnt tN{A $t{t{* ta \ A u'10 t0 P'$te.

- NeYs hd0y\ o,\$\nNA a40U th v0$!t A $te th brtU$qh $o mr*

0rirurnql IINA.

Staqo 4'Ter.ruunrmonrSt!? a{0, t^,rrors I SnoO{ lthrr&r^,rg

UAq hAA UqA

t. Ra\tftsL to.$sv iY$tqqj brhrllt 9trlt,:*or. rrr A s\t{ rhftsc.d ')t

tlNA

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a. +lqo\o\1ere 4*\r'e amp'.e*e{ Po\ttF-hrle{{\, ,\tltNAin p a*a

4. Fg\sftse 0t Dtrll{Pst{Ao +.rd,'ijll^ s-\(t fiqhg\ E lctv4o n'00(0!l{41 $rrd^!r*

S. Rgr*niwlg\. d 1Yq$rit$al fi.*&,a&+, etl|.ea aPrt auc{ r( vefir\erl.,

5.?ost-lvtvdqnoual pyseq$\,,{ { ?v0tsv\ SOt{r 0

hgt-t\,an(haoyal ms{rtro*rsvt

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Page 22: Cells, Dna, Genomics

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Page 23: Cells, Dna, Genomics

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Page 24: Cells, Dna, Genomics

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