Cell Biology of Sex

Cell Biology of Sex

Barry Bean

for BioS 10 & 90

18 September 2009

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Poll

Bean

Poll

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A.D.2000

A.D.

1000A.D.

1

1000

B.C.

2000

B.C.3000B.C.

4000B.C.

5000

B.C.

6000

B.C.

7000B.C.

1+ million years

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7

6

5

2

1

4

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OldStoneAge New Stone Age

BronzeAge

IronAge

MiddleAges

ModernAge

Black Death —The Plague

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10

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A.D.3000

A.D.4000

A.D.5000

1800

1900

1950

1975

2000

2100

Future

Billions

Source: Population Reference Bureau; and United Nations, World Population Projections to 2100 (1998).

World Population Growth Through History

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Fig. 13-01from Sylvia Mader, Human Reproductive Biology,

3rd. ed., 2005

Population growth rate ~ 1.2

Doubling time ~ 58 yrs

(PRB)

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It’s all about YOU…

The most important day of your life…

Poll

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World Population Clock

math.berkeley.edu/~galen/popclk.html

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Figure 1. Montage transmission electron micrograph of a human sperm cell. The cell has a compact nucleus, conspicuous mitochondria, no endoplasmic reticulum, minimal cytoplasm and a large tail (about 45 μm in length). Superfluous cytoplasm and associated machinery is jettisoned when the sperm emerges from the testis, leaving a 'stripped down', minimalist cell.Barratt et al. Journal of Biology 2009 8:63 doi:10.1186/jbiol167

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“Mammalian Fertilization” R.Yanagimachi, 1994.

http://usuarios.lycos.es/biologiacelular1/Aparato%20reproductor%20

masculino8_archivos/532047.jpg

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Assignment for Points:

Portray the role of each

compartment

Used with permission of the artist, Patrick Moberg

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Try to

remember…

when you

were

gametes !

Think like a sperm…

Think like an oocyte… 11

Gametes are prefabricated for action, a

cascade of functions.

Gamete production includes unique

patterns of gene expression and

regulation.

Gametes have complex structure and

many phenotypes.

Every Gamete is a genetically distinct

human individual!

Here’s where they came from…12

from Sylvia Mader,

Human

Reproductive

Biology, 3rd ed.

All sexually

reproducing

organisms do

something like

this!

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Zygo- = yoked,

paired [Greek]

Fig. 05-05Your parents…

When

fetuses…

from Sylvia Mader,

Human Reproductive

Biology

PGCs, Primordial

Germ Cells

populated the

presumptive

gonadal tissue…

(And YOU)

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9

14

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from Sylvia Mader,

Human

Reproductive

Biology, 3rd ed.

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Fig. 01-09from Sylvia Mader,

Human

Reproductive

Biology, 3rd ed.

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From Alberts et al., Molecular Biology of the Cell, 5th ed., 2008

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from Sylvia Mader, Human Reproductive Biology

250 m

0.16 miles

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From Alberts et al., Molecular Biology of the Cell, 5th ed., 200819

From: Rupert Amann, Journal of Andrology,

Vol. 29, No. 5, September/October 2008

DSP = daily sperm production ~108/day

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Fig. 06-07from Sylvia Mader,

Human

Reproductive

Biology, 3rd ed.

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From Alberts et al., Molecular Biology of the Cell, 5th ed., 200822

http://www.shoppbs.org/product/index.jsp?productId=1402972

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Fertilization

Green=Acrosome

Purple=Zona

Pelludica

Gray= Sperm w/out

Acrosome

**note that the

acrosome

compartment

opened after contact

with the zona

pellucida

http://www.nature.com/fertility/content/images/ncb-nm-fertilitys57-f1.jpg24

http://www.cnuh.co.kr/kckang/FemaleReproductiveMedicine/images/fig2

5-003.png 25

From Cell Mol Life Sci 64 (2007)

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Fig. 08-01

from Sylvia Mader, Human Reproductive Biology, 3rd ed.28

From Alberts et al., Molecular Biology of the Cell, 5th ed., 200829

Jennifer Venditti 30

From Alberts

et al.,

Molecular

Biology of

the Cell, 5th

ed., 200831

from Sylvia Mader, Human Reproductive Biology

And then…

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Questions

Discussion

Editorials

Jokes

Thanks! Watch DVD

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