CD14 and Toll-like Receptors CD14 and Toll-like Receptors Regulate Lipopolysaccharide Regulate Lipopolysaccharide Induction of KGF-1 Protein Induction of KGF-1 Protein Expression Expression EE Putnins*, Sanaie AR, Firth JD, Wu Q. Faculty of Dentistry The University of British Columbia Vancouver, B.C., CANADA
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CD14 and Toll-like Receptors Regulate CD14 and Toll-like Receptors Regulate Lipopolysaccharide Induction of KGF-1 Lipopolysaccharide Induction of KGF-1
Protein ExpressionProtein Expression
EE Putnins*, Sanaie AR, Firth JD, Wu Q.
Faculty of Dentistry
The University of British Columbia
Vancouver, B.C., CANADA
IntroductionIntroduction Abnormal epithelial cell
proliferation is one aspect of PDD onset and progression.
Understanding the regulators of early disease onset may explain why some individuals are resistant/susceptible to disease.
If the epithelial barrier is perturbed then LPS from Gram negative microorganisms is likely to stimulate gingival fibroblasts.
Fibroblast Growth FactorsFibroblast Growth FactorsInterested in paracrine mediated epithelial
specific growth factors.
– Growth factors that are secreted by fibroblasts and specifically stimulate epithelial cell proliferation and migration.
– Keratinocyte Growth Factors-1 (FGF-7) and -2 (FGF-10).