BWF Programs and Priorities January 23, 2008 U.S. Veterans Administration Office of Research and Development Research Cyber Seminar Nancy Sung, Ph.D.
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BWF Programs and Priorities
January 23, 2008U.S. Veterans Administration Office of Research and DevelopmentResearch Cyber Seminar
Nancy Sung, Ph.D.
Outline
• Funding for Biomedical Research
• About Burroughs Wellcome Fund
• Mission and Strategy
• Award Programs
0
50
100
150
200
250
300
1965 1970 1975 1980 1985 1990 1995 2000 20050
50
100
150
200
250
300
1965 1970 1975 1980 1985 1990 1995 2000 2005
Recessions in green: 1969–70; 1973–75; 1980; 1981–82; 1990–91; 2001Recessions in green: 1969–70; 1973–75; 1980; 1981–82; 1990–91; 2001
Inflation-adjusted dollarsInflation-adjusted dollarsCurrent dollarsCurrent dollars
($ in billions)($ in billions)TOTAL GIVING, 1965–2005
Steep growth 1996-2000Source: Giving USA, 2007
•
GIVING BY FOUNDATIONS, 1965–2005($ in billions)($ in billions)
Data: The Foundation CenterData: The Foundation Center
30.00
24.58
1.90
10.567.23
1.13 1.65 2.814.90
27.88
13.5310.80
5.998.89
6.667.019.56
1965 1970 1975 1980 1985 1990 1995 2000 2005
30.00
24.58
1.90
10.567.23
1.13 1.65 2.814.90
27.88
13.5310.80
5.998.89
6.667.019.56
1965 1970 1975 1980 1985 1990 1995 2000 2005
Current dollarsInflation-adjusted dollars
•Tripling of foundation giving from 1995-2005•Number of foundations nearly doubled,
now over 71,000 (50/week)
•Foundation assets in 2006: over $550 billion•Foundation payout in 2006: $40.7 billion
Environmentand animals
$8.863.4%
Foundations$21.70 8.3%
Human services$25.36 9.7%
Internationalaffairs$6.392.5%
Arts, culture, and humanities
$13.515.2%Public-society
benefit$14.035.4%
Unallocatedgiving$16.156.2%
Health $22.548.7%
Religion $93.18 35.8%Education
$38.56 14.8%
WHERE DID THE $260.28 BILLION GO?
Grants for biomedical, translational and clinical research account for about 4% of the total
0
20
40
60
80
100
120
140
1996 1998 2000 2002 2004 2006
Year
Fu
nd
ing
, $
in B
illi
on
s
Medical Device Firms
Biotechnology Firms
Pharmaceutical Firms
Private Funds
State & Local Govt.
Federal Support Other than NIH
National Institutes of Health
Funding the Biomedical Research Enterprise
Total investment tripled since 1996
Majority funded by industry
Proportion from private, non-profit unchanged
Source: JAMA 2005; 294:1333-1342; Hamilton Moses, Alerion 2007
The Two Translational Blocks
Translation from basic science to
human studies
Translation ofnew knowledge
into clinical practice
Basic Biomedical
Research
Clinical Science
and Knowledge
Block 1
Block 2
Goal: Improved
Health
Adapted from IOM Clinical Research Roundtable
This is not the goal!
Adapted from IOM Clinical Research Roundtable, 2002
Funding the Health Research Continuum
Basic Biomedical
Research
Clinical Science
and Knowledge
Block 1
Block 2
Goal: Improved
Health
Adapted from IOM Clinical Research Roundtable
NIH AHRQ
PHARMA
VHAs: ACS, AHA, ADA, CFF
HHMI, DDCFBWF
RWJF
Health Foundations?
Under what conditions should philanthropy support biomedical research?
Under what conditions should philanthropy support biomedical research?
“[Foundations should] concentrate resources on problems that are not being dealt with by governments or for-profit organizations. Being constrained by neither voters nor shareholders, they can take risks to find pioneering new solutions that can then be adopted on a larger scale by governments or for-profit firms”
The Business of Giving: A Survey of Wealth and Philanthropy, The Economist, 2006.
Silas Mainville Burroughs (1880 photo) started his career as a pharmaceutical sales representative in Philadelphia and moved to London in 1878 as an
agent for a U.S. drug firm.
Henry Wellcome enrolled in the Chicago College of Pharmacy in 1872 and finished his
education at the Philadelphia College of Pharmacy, where me met Silas Burroughs.
1955 Burroughs Wellcome Fund (BWF) created as the corporate foundation of the U.S. company
1993 The Wellcome Trust sells the company and endows BWF with $400 million; Burroughs Wellcome Co. contributes $30 million to give BWF complete independence
2008 Endowment grows to $800 million
History of the Burroughs Wellcome Fund
Top 10 U.S. Foundations Awarding Grants for Medical Research, 2005*
Foundation Amount, US $
No. of Grants
Bill and Melinda Gates Foundation 270,976,718 26
The Starr Foundation 33,075,000 14
Burroughs Wellcome Fund 25,804,239 83
Flight Attendant Medical Research Institute, Inc. 20,461,776 143
Avon Foundation 16,216,577 16
The Dana Foundation 15,506,843 50
W.M. Keck Foundation 14,970,000 16
The Picower Foundation 13,198,221 8
Eli & Edythe L. Broad Foundation 12,689,219 45
The Robert A. Welch Foundation 10,960,000 37
*Based on grants of $10,000 or more awarded by a national sample of 1010 larger U.S. foundations.Source: JAMA 2005; 294:1333-1342
Burroughs Wellcome Fund
“To advance the biomedical sciences by supporting research and other scientific
and educational activities.”
• Career development of outstanding young scientists
• Development of investigators in targeted areas of science that are undervalued or underfunded
Grantmaking Strategies
Independent private foundation
Endowment of ~ $800 million
Award ~$40 million annually in US & Canada
~ 85% of our grants are made through competitive peer-reviewed award programs
Each program has an Advisory Committee
~ 15% of our grants are catalytic and adhoc
~ Engage in “Terrain” Mapping every five years
About BWF. . .
BWF Board of Directors
• J. Michael Bishop, M.D.
University of California at San Francisco
• Enriqueta C. Bond, Ph.D.
Burroughs Wellcome Fund
• Carlos J. Bustamante, Ph.D.
University of California-Berkeley
• Geoff Gerber, Ph.D.
TWIN Capital Management
• Phil Gold, M.D., Ph.D. (chair)
McGill University
• I. George Miller, M.D.
Yale University School of Medicine
• Mary-Lou Pardue, Ph.D.
Massachusetts Institute of Technology
• Jerome F. Strauss, III, M.D.
Virginia Commonwealth University
• Judith Swain, M.D.
University of California-San Diego
• Philip R. Tracy, Esq.
Smith, Anderson, Blount, Dorsett, Mitchell & Jernigan, L.L.P.
Basic Medical Sciences
Interfaces in Science
Infectious Disease
Translational Research (bench to bedside) Science Education
Population Laboratory-based biological sciences
Science and Philanthropy
Focus Areas
Competitive Program Matrix
Eligible applicants
Institutions Postdoctoral fellows
UniversityFaculty
Type of science
K-12 education Student Science Enrichment Program
Physician scientists Career Awards in the Medical Sciences
Clinical Scientist Awards in Translational Research
Investigators in Pathogenesis of Infectious DiseaseInfectious disease
investigators
Interdisciplinary science
New population/basic science program
Career Awards at the Scientific Interface
Hitchings Elion Fellowship
Biomedical Sciences
Wellcome Research Travel Grants
1978
Evaluation:Annual Advisory Committee reviewsAcademic Medicine78:177-186, 2003Comparative MS Complete
Career Development:Awardee ConferencesInformal Awardee UpdatesLab Management CourseHelp with Individual IssuesLab ManualCareer Development Pieces on website
Field Development:Professional Society SupportSupport for outside studies and Initiatives Preterm Birth Initiative
Training Programs:Frontiers in ReproductionAAOGFRSDP
1992 1995 2007
Career Awards at theBiomedical Sciences
Career Awards forMedical Scientists
20061999
Basic Medical Sciences
Target D.D.S., D.V.M., M.D., or M.D.-Ph.D. degreeWorking in any basic biomedical science, with not more than 120 months past most recent doctorateDisease-oriented, translational or molecular, genetic or pharmacological epidemiology research
Amount $700,000 over five years
Career Awards in the Medical Sciences (CAMS)
Deadline October 1
Goal To bridge advanced postdoctoral training, or fellowship & the first years of faculty service
Interfaces in Science:Physical/mathematical/computational science and biology
Institutional Awards at the Scientific Interface (IASI)
1996 2000 2001 2008
Career Awards at the Scientific Interface (CASI)
Evaluation:Progress report review2003: Science 301:14852007: Trainee Outcomes project
Career Development:Lab management courseFaculty offer analysis Awardee convening events
Innovation Awards in Functional Genomics
Field Development:“Bridging the Sciences” initiativeSupport for professional societiesDisseminating experience at NIH, NSF, HHMI, NAS
Training Programs:MBL Modeling CourseMBL Physiology CourseKITP Programs
Interfaces in Science
Target - Ph.D. degree in physical/mathematical/ computational sciences - Working to address biological questions- With at least 12 months, but not more than 48 months
of postdoctoral training
Amount $500,000 over five years
Career Awards at the Scientific Interface (CASI)
Deadline April 15
Goal To bridge advanced postdoctoral training & the first years of faculty service
Interfaces in Science
U.S. or Canadian citizens orpermanent residents
Career Awards at the Scientific Interface (CASI)
Foreign scientists who present evidence that lawful immigration status has been granted
& will extend through award duration
Eligibility Exception
(only one such nominee per institution)
BWF/WT Joint program
Infectious Diseases
Scholars in Molecular Parasitology
Field Development:
Woods Hole Parasitology courseSocieties
Woods Hole MycologyIOM Microbial Threats Forum
NIAID Fungal WorkshopsSupport for small meetings
Investigators inPathogenesis of
Infectious Diseases
BWF/ASTMHID Fellowships
Field Development:
Aspergillus genomesC.albicans genome
Cryptococcus genomePlasmoDB
Tri-tryps genomesMalaria genomes
Malaria Next StepsNew tools for work on Metazoan Parasites
Career Development:
Communicating ScienceGrant writing course
Network BuildingAwardee Meetings
Lab Management BookInternational Lab Management Book
1981 1990 1995 1999 2000 2005
New Investigators in Molecular Parasitology
Scholars in Mycology
New Investigatorsin Mycology
Infectious Disease
Target - M.D. or Ph.D. - Assistant Professor with record of independent research
Amount $500,000 over five years
Investigators in Pathogenesis of Infectious Disease
Deadline November 1
Goal To provide new opportunities for accomplished investigators at the Asst. Professor level to study pathogenesis
TRANSLATIONAL RESEARCH
Scholar Awards in
Experimental Therapeutics
Clinical Scientist Awards in Translational Research
Field Development:IOM Clinical Research Roundtable, Drug ForumOther IOM, AAMC studies Support for professional societiesClinical research ethics, conflict of interestHealth Research Alliance
Career Development:Awardee/trainee convening eventsAAMC, APM initiatives on clinical investigator career trackDrug Development courseAAAS website for physician scientists
1997 2007
Translational Research
Target - M.D. or M.D.-Ph.D. degree - late Assistant Professor or early Associate Professor
Amount $750,000 over five years
Clinical Scientist Awards in Translational Research
Deadline October 1
Goal To foster the development of established independent physician-scientists whose work bridges gap between “bench and bedside”
PHYSICIAN SCIENTISTS AT BWF
Career Awards in the
Medical Sciences Clinical Scientist Awards in Translational Research
Field Development:IOM Clinical Research Roundtable, Drug ForumOther IOM, AAMC studies Support for professional societiesClinical research ethics, conflict of interestHealth Research Alliance
Career Development:Awardee/trainee convening eventsAAMC, APM initiatives on clinical investigator career trackLab management courseAAAS website for physician scientists
Postdocs Early faculty Mid career faculty
Investigators in Pathogenesis of Infectious Disease
Externally managed programs:ASTMH fellowshipsACOG/ AAOGF fellowshipsMBL courses
Bridges between the Population andLaboratory based Sciences
Field Development:
EpidemiologyEconometricsComputer ModelingEvolutionary BiologyPublic Health and more!
Bridges between the Population and Laboratory based Sciences
Field Development:
Advanced CoursesSocietiesAwardee Trainee GatheringsNetworking with existing BWF familySupport for small meetings
Field Development:
Trainee movement across institutionsProgram EvaluationCrosstalk with non-biological fields
Population Sciences
Target Degree-granting institutions in the US and Canada
Amount $500,000 per year for five years
Institutional Program Unifying Population and Laboratory-based Sciences
Deadline Letter of intent: March 3Full application (invitation only) May 15
Goal The programs supported by these awards will develop young researchers who will be equally at home with the ideas, approaches, and insights generated at the molecular scale and at the population scale.
BWF Science Education North Carolina Program
UNC Fast Track
Student Enrichment
Public Policy
NC Network of Education Funders
Convene AwardeesEvaluation Workshops
Sustainability Workshops
Proposal Writing
NC Grassroots Museum
Collaborative
NC School of Science and Math Education Future
Center
Institutional Capacity
Partnership Building
K-12 Outreach Conference NC SMT
Education Center
Teacher Development
NSRC LASER
1996 2007
Student Science
Enrichment Program
Institute for Educational
Policymakers
Science Education
Target non-profit organizations in North Carolina
Amount Up to $180,000 over three years
Student Science Enrichment Program (SSEP)
Deadline April 10
Goal To support creative inquiry-based science enrichment activities for elementary, middle and high school students
Science & Philanthropy
Target Non-profit organizations
Amount Varies
Noncompetitive “Complementary” Grants
Deadline Received all year
Goal To support activities that are closely related to our targeted areas and are intended to improve the general environment for science
Award Programs
Grants Awarded* by Focus Area: FY 2006
Interfaces in Science
13%Infectious Disease
23%
Translational Research
19%
Science Education
12%
Science & Philanthropy
1% Biomedical Sciences
32%
*Millions of dollars
Total Grants Awarded $39.6 M
Is this how it works?Is this how it works?
Info for Applicants
The Selection Process
Application by Nominated Candidates
Review by Scientific Advisory Committee
Initial Scoring Leads to Finalists
Advisory Committee Interviews All Finalists
Recommend Awardees to Board of Directors
Board Approval
Primarily to degree-granting institutions on behalf of researchers, who must be . . .
Secondarily to non-profit organizations conducting activities to improve the environment for science
Grants are made . . .
Info for Applicants
• Nominated by their institution
• Citizens or permanent residents of the US or Canada *
* An exception is made for one program
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