Copyrightpharmrev.aspetjournals.org/content/pharmrev/18/1/local/front...BUEDING, ERNEST Johns Hopkins ... GREEN, A.P. Burroughs Wellcome Research Laboratories, ... Farmakoldski Institut

Copyright ©� 1966, BY THE WILLIAMS & WILKINS Co.

SECOND SYMPOSIUMON

CATE CHOLAMINE S

rrrn+i��1 �ii

Held at the

Istituto di Ricerche Farmacologiche “Mario Negri,” Milano.

July 4 to 9, 1965

Under the Editorship of

GEORGE H. ACHESON, M.D.

Published for the

American Society for Pharmacology and

Experimental Therapeutics

BY

The Williams & Wilkins CompanyBaltimore, Maryland 21202, U.S.A.

1966

Copyright ©, 1966, THE WILLI�ss & WILKINs Company

All Rights Reserved

Made in the United States of America

Composed and printed at

WAVERLY PRESS, INC

Baltimore, Md. 21202

PHARMACOLOGICAL REviEws VoL 18, No. 1, Part I

Copyright © 1966 by The Williams & Wilkins Co. Printed in U.S.A.

FOREWORD

The first Catecholamine Symposium was held at the National Institutes of

Health, Bethesda, Maryland, October 16 to 18, 1958. That symposium (Pharma-

col. Rev. 11: 241-566, 1959) summarized information and ideas in this field up

to 1958 and stimulated many scientists in their subsequent researches. The

decision to hold a Second Catecholarnine Symposium was made in April 1964,

and an Organizing Committee was created, composed of J. Axeirod, B. B. Brodie,

C. A. Chidsey, E. Costa, J. R. Crout, D. H. Efron, N. J. Giarman, i\I. Gold-

stein, S. Kaufman, S. Kety, I. J. Kopin, C. C. Porter, F. E. Shideman, P. A.

Shore, A. Sjoerdsma, S. Spector, D. Steinberg, C. Stone, E. W. Sutherland, and

H. Weil-Malherbe, with S. Udenfriend as Chairman. This committee was re-

sponsible for arranging the scientific program and made the decision to hold the

symposium in Europe. The gracious offer of Prof. S. Garattini to use the facili-

ties of the Istituto di Ricerche Farmacologiche “Mario Negri” in Milano, Italy,

was accepted and the Symposium was held at that institute July 4 to 9, 1965.

Prof. S. Garattini and his associate, Prof. A. Leonardi, were responsible for

creating an environment most conducive to the presentation and exchange of

scientific ideas.

The Second Catecholamine Symposium received its major financial support

from the National Institute of Mental Health, National Institutes of Health,

Bethesda, Maryland (NIMH contract no. PH 43-65-54). This was awarded to

the American Society for Pharmacology and Experimental Therapeutics, which

accordingly assumed the responsibility for administering the contract. Its admin-

istration was delegated to the Executive Officer of the Society, Dr. E. Cook. Ad-

ditional financial support was received from the Ministero della Pubblica Istru-

zione and the Ministero della Sanit#{224}of the Italian government, and from the

following private organizations: Abbott Laboratories, North Chicago, Ill., U.S.A.;

American Instrument Co., Silver Spring, Md., U.S.A.; Astra Pharmaceutical

Products, Inc., Worcester, Mass., U.S.A.; Boehringer Sohn, Ingelheim am

Rhein, Germany; Calbiochem, Los Angeles, Calif., U.S.A.; CIBA S.p.A., Milano,

Italy; Crinos S.p.A., Civello di Villaguardia, Como, Italy; Geigy S.A., Basel,

Switzerland; Geigy Research Laboratories, Yonkers, N.Y., U.S.A.; Hoffmann

La Roche S.A., Basel, Switzerland; Institute for Medical Research and Studies,

New York, U.S.A.; Lepetit S.p.A., Milano, Italy; N’Iaggioni S.p.A., ?�Tilano,

Italy; Martini & Rossi Co., Milano, Italy; Merck Sharp and Dohme Co., Inc.,

Rahway, N.J., U.S.A.; New England Nuclear Corporation, Boston, U.S.A.:

Olivetti, Ivrea, Italy; Roussel Uclaf, Paris, France; Sandoz S.p.A., i\Iilano,

Italy; Schering Corporation, Bloomfield, N.J., U.S.A.; Senheiser Electronic,

Hanover, Germany and Exibo Italiana S.r.L., Milano, Italy; Smith Kline &

French Laboratories, Philadelphia, Pa., U.S.A.; Sterling Winthrop Research

Institute, Rensselaer, N.Y., U.S.A.; Warner Lambert Research Institute, I\ior-

ris Plains, N.J., U.S.A.: Wellcome Foundation Ltd., London, England; Well-

come Foundation, Tuckahoe, N.Y., U.S.A.; Academic Press, Inc., New York,

U.S.A.; and Farbenfabriken Bayer AG, Wuppertal-Elberfeld, Germany.

3

4 FOREWORD

Participation in the Symposium did not impose upon the contributors strict

uniformity in presentation, order of material, or nomenclature. Accordingly, for

purposes of publication these diversities remain. Special problems raised by

variations in the names of compounds, of techniques and of apparatus will be

evident. Differences in nomenclature, indeed, still may emphasize an ever-

present need within the medical sciences for continued efforts toward a commonusage. In accordance with the policy of Pharmacological Reviews, the editors

have attempted to follow either of two canons of spelling and nomenclature,

the British and the American, according to the author’s preference. A reporter

was assigned to each session to provide an account of the comments made duringthe discussion period, including his own editorial observations on the proceedings

at that session.

The following deserve thanks for their trouble and care in participating in the

editorial process: Charles Chidsey, Erminio Costa, Robert F. Furchgott, Sey-

mour Kety, George B. Koelle, Neil C. Moran, and J. R. Vane.

GEORGE H. ACHESON, Editor

Sn�EY UDENFRIEND, Chairman of the Organizing Committee

PHARMACOLOGICAL REVIEWS Vol. 18, No. 1. Part I

Copyright © 1966 by The Williams & Wilkins Co. Printed in U.S.A.

PARTICIPANTS IN THE SYMPOSIUM

ACHESON, GEORGE H.

Department of Pharmacology, College of 1\Iedicine, University of Cincin-

nati, Eden Ave., Cincinnati 19, Ohio

AND1�N, N. E.

Department of Pharmacology, University of Goteborg, Medicina Regatan

7, Goteborg, Sweden

ANGELETFI, P. U.

Department of Zoology, Washington University, St. Louis, Missouri

ARCHER, SIDNEY

Chemical Research and Development, Sterling-Winthrop, Rensselaer,

New York

AXELROD, JULIUS

Laboratory of Clinical Sciences, National Institute of Mental Health, Be-

thesda 14, Maryland

BACQ, Z. M.

Laboratoire de Pathologie et Th#{233}rapeutique G#{233}n#{233}rale,Universit#{233} de Liege,

32, Boulevard de la Constitution, Liege, Belgique

BANKS, PETER

Department of Biochemistry, The University, Sheffield 10, England

BARTONICEK, VACLAV

Psychiatric Research Institute, Prague 8, Czechoslovakia

BELFORD, JULIUS

Department of Pharmacology, State University of New York, Downstate

Medical Center, 450 Clarkson Ave., Brooklyn 3, New York, New York

BELLEATJ, B.

Department of Chemistry, Faculty of Pure and Applied Science, University

of Ottawa, Ontario, Canada

BEItTLER, A.

Department of Pharmacology, University of Lund, Lund, Sweden

BIEL, JOHN

Aldrich Chemical Co., Inc., 2371 North 30th Street, Milwaukee, Wisconsin

53210

BIzzI, A.

Istituto di Ricerche Farmacologiche “Mario Negri,” Via Eritrea 62, Milano,

Italy

BLAKELEY, A. G. H.

University Laboratory of Physiology, South Parks Road, Oxford, England

BLASCHKO, HERMANN

Department of Pharmacology, South Parks Road, Oxford, England

BONACCORSI, AURORA

Istituto di Ricerche Farmacologiche “Mario Negri,” Via Eritrea, 62, Milano,

Italy

14

PARTICIPANTS 15

BOOKER, W. i\’I.

Department of Pharmacology, Howard University School of i\Iedicine,

Washington 2, D. C.

BRADLEY, P. B.Department of Experimental Neuropharmacology, The Medical School,

Birmingham 15, England

BRODIE, BERNARD B.Laboratory of Chemical Pharmacology, National Heart Institute, Bethesda

14, Maryland

BRODY, THEODORE M.

Department of Pharmacology, University of Michigan, M. 6322 Medical

Science Building, Ann Arbor, Michigan

BRUCKE, F.

Pharmakologisches Institut der Universit#{228}t, Wahringerstrasse 13a, Wien

IX, Austria

BRUNJES, SHANNON D.1200 North State Street, Los Angeles, California

BUEDING, ERNEST

Johns Hopkins University School of Hygiene and Public Health, Depart-

ment of Pathobiology, 615 North Wolfe Street, Baltimore, Maryland

BULBRING, E.

Department of Pharmacology, South Parks Road, Oxford, England

BURN, J. H.

Oxford University, 2 Capel Close, Oxford, England

BURNSTOCK, G.Department of Zoology, University of Melbourne, Parkville, N. 2, Victoria,

Australia

BUTCHER, R. W.Department of Physiology, Vanderbilt University Medical School, Nash-

ville, Tennessee

BUYSKE, D. A.Lederle Laboratories, Pearl River, New York

CAPON, A.Laboratoire de Pathologie G#{233}n#{233}rale,Universit#{233} de Bruxelles, Belgium

CARLSON, L. A.King Gustaf V#{176}Research Institute, Karolinska Hospital, Stockholm 60,

Sweden

CARLSON, LOREN D.Department of Physiology and Biophysics, University of Kentucky Medical

Center, Lexington, Kentucky

CARLSSON, ARVID

Department of Pharmacology, University of Goteborg, Goteborg, Sweden

CAPRI, A.Department of Therapeutic Chemistry, Istituto Superiore di Sanit#{224},Viale

Regina Elena 299, Rome, Italy

16 PARTICIPANTS

CHENOWETH, M. B.Biochemical Research Laboratory, 1701 Building, The Dow Chemical Co.,

Midland, Michigan

CHIDSEY, CHARLES

Department of Medicine, University of Colorado School of Medicine,

Denver, Colorado

CLARK, WILLIAM G.Veterans Administration Hospital, Department of Psychopharmacology,

Sepulveda, California

COOK, ELLSWORTH B.American Society for Pharmacology and Experimental Therpeutics, Inc.,

9650 Wisconsin Avenue, Washington, D. C.

COOPER, T.Department of Surgery, St. Louis University, School of Medicine, 1325

South Grand Boulevard, St. Louis, Missouri

Corn, CARL

Department of Biochemistry, St. Louis University, 1402 South Grand

Boulevard, St. Louis, Missouri

C0RR0DI, HANS

A. B. Hassle, Anders Personsgatan, Box 691, GOteborg 6, Sweden

COSTA, ERMINIO

Department of Pharmacology, College of Physicians and Surgeons, Colum-

bia University, New York, New York

CREVELING, CYRUS ROBERT

National Institute of Arthritis and Metabolic Diseases, Bethesda 14, Mary-

land

CROUT, J. RIcHARDDepartments of Pharmacology and Internal Medicine, University of Texas,

Southwestern School of Medicine, 5323 Harry Hines Boulevard, Dallas,

Texas

DAHLSTROM, ANNICA

Department of Histology, Karolinska Institute, Stockholm, Sweden

DAVIS, Ross

Neurophysiology Laboratory, Psychiatric Research Unit, Callan Park,

Rozelle, Sydney, Australia

DELLA BELLA, D.

Zambon S.p.A., Via Lillo del Duca 12, Milano, Italy

DENGLER, HANS

Medizinische-Universit#{228}tsklinik, Bergheimerstra.sse 58, Heidelberg, Ger-

many

DE ROBERTIS, E.

Instituto de Anatomia General y Embriologia, Paraguay 2155 P. 2#{176},Buenos

Aires, Argentia

PARTICIPANTS 17

DE SCHAEPDRYVER, A. F.

Department of Pharmacology, Ghent University, School of Medicine,

Albert Boertsoenkaai 3, Ghent, Belgium

D’Iorno, ANTOINE

Department of Biochemistry, University of Ottawa Faculty of Medicine,

Ottawa, Ontario, Canada

DOEPFNER, WOLFANG

Sandoz Pharmaceuticals, Medical Department, Basle, Switzerland

DOMINGUEZ, ABEL M.

Biosciences Division, European Office of Aerospace Research, Shell Build-

ing, 47 Cantersteen, Bruxelles, Belgium

DORNHORST, A. C.

St. George’s Hospital, Medical School, London, England

DOUGLAS, W. W.

Department of Pharmacology, Albert Einstein University Medical School,

1300 Morris Park Avenue, Bronx 61, New York

DRAIN, D. J.

Smith and Nephew Research Ltd., Gilston Park, Harlow, Essex, England

DRELL, WILLIAM

Calbiochem Corporation, 3625 ?vledford Street, Los Angeles 63, California

DUBNICK, BERNARD

Warner-Lambert Research Institute, Morris Plains, New Jersey

EFRON, DANIEL

Psychopharmacology Service Center, National Institutes of Health, Be-

thesda, Maryland

ELLENBOGEN, LEON

Lederle Laboratories, Pearl River, New York

ELLIS, SYDNEY

Department of Pharmacology, Woman’s Medical College of Pennsylvania,

3300 Henry Avenue, Philadelphia, Pennsylvania

EI�XNxO, OLAVI

Department of Anatomy, University of Helsinki, Siltavuorenpenger, Hel-

sinki, Finland

EULER, U. S. VON

Fysiologiska Institutionen I, Karolitiska Inst itutet, Solnavagen, Stock-

holm, Sweden

EVERETT, GUT M.

Department of Pharmacology, Abbott Laboratories, Scientific Division,

North Chicago, Illinois

FALK, BENGT

Department of Histology, University of Lund, Lund, Sweden

FEKETE, MARTON

Department of Pharmacology, Research Institute for Pharmaceutical

Chemistry, Szabadsagharcosok u 47-49, Budapest 4, Hungary

18 PARTICIPANTS

FELDBERG, W. S.

National Institute for Medical Research, Mill Hill Road, London, England

FRIEDMAN, STANLEY

Department of Molecular Biology, Gibbs Research Labs., Yale Station Box

2166, New Haven, Connecticut

FURCHGOVr, ROBERT F.

Department of Pharmacology, State University of New York, Downstate

Medical Center, 450 Clarkson Ave., Brooklyn 3, New York

FUXE, KJELL

Department of Histology, Karolinska Institutet, Stockholm, Sweden

GAFFNEY, THOMAS E.

Department of Pharmacology, College of Medicine, University of Cinch-


GARATrINI, SILVI0


Italy

GE5SA, GIAN L.

Istituto di Farmacologia, University of Cagliari, Cagliari, Italy

GEY, K. F.

Hoffmann-La Roche and Co., Basle, Switzerland

GILLESPIE, J. S.

Department of Physiology, Glasgow University, Glasgow, Great Britain

Gimow, STANLEY E.

Mt. Sinai Hospital, 5th Ave. and 100th St., New York, New York

GJESSING, LEIV

Dikemark Hospital, Asker, Norway

GLOwINSKI, JACQUES

Laboratory of Clinical Science, National Institute of Mental Health, Be.

thesda, Maryland

GOLDBERG, LEON I.

Department of Pharmacology, Emory University School of Medicine,

Atlanta, Georgia

GOLDFIEN, ALAN

Department of Medicine, University of California Medical Center, San

Francisco, California

GOLDSTEIN, MENEK

Department of Biochemistry, New York University Medical Center, 550

First Avenue, New York, New York

GORKIN, V.

Institute of Biological and \Iedical Chemistry, Academy of Medical Sci-

ences of the USSR, Pogodinska 10, Moskow G-117, USSR

GOTH, ANDRES

Department of Pharmacology, University of Texas, Southwestern Medical

School, .5323 Harry Hines Blvd., Dallas 35, Texas

PARTICIPANTS 19

GREEN, A. P.Burroughs Wellcome Research Laboratories, Langley Court, Beckenham,

Kent, England

GREEN, HARRY

Smith, Kline and French Laboratories, 1500 Spring Garden Street, Phila-

delphia 1, Pennsylvania

GRILLO, MARY

Department of Anatomy, Western Reserve University Medical School,

Cleveland, Ohio

GROSSMAN, S. P.

Department of Psychology, University of Chicago, Chicago, Illinois 60637

HAGGENDAL, J.

Department of Pharmacology, University of Goteborg, Goteborg, Sweden

HAMBERGER, BERTIL

Department of Histology, Karolinska Institutet, Stockholm, Sweden

HARRISON, WILLIAM HENRY

Department of Neurology, Presbyterian St. Luke’s Hospital, Chicago,

Illinois

HAUGAARD, N.

Department of Pharmacology, University of Pennsylvania Schools of Medi-

cine, Philadelphia, Pennsylvania

HAYAISHI, OSAMU

Department of Medical Chemistry, Kyoto University Faculty of Medicine,

Sakyo-ku, Kyoto, Japan

HELMREICH, ERNST

Department of Biological Chemistry, Washington University School of

1\iedicine, 660 South Kingshighway, St. Louis, Missouri

HERTTING, G.

Pharmakologisches Institut (1cr Universit#{228}t,Waehringerstrasse 13a, Wien

IX, Austria

HESS, MARILYN

Department of Pharmacology, University of Pennsylvania Schools of

1\iedicine, Philadelphia, Pennsylvania

HESS, SIDNEY

Squibb Research Institute, New Brunswick, New Jersey

HOLMAN, M.

Department of Physiology, University of Monash, Clayton, Victoria,

Australia

HOLTZ, P.

Pharmakologisehes Institut der Universit#{228}t, Ludwig-Rehn Str. 14, Frank-

furt am M., Germany

HORITA, AKIRA

Department of Pharmacology, School of i\Tedicine, University of Washing-

ton, Seattle, Washington

20 PARTICIPANTS

HORNYKIEWICZ, 0.

Pharmakologisches Institut der Universit#{228}t,Wahringerstrasse 13a, Wien LX,

Austria

HRDINA, PAVOL

Department of Pharmacology, Komensky University, Bratislava, Czecho-

slovakia

HUKOVIC, S.

Farmakoldski Institut Mediciniski Facultet, Sarajevo, Yugoslavia

HYNIE, S.

Department of Pharmacology, Charles University, Prague, Czechoslovakia

IVERSEN, LESLIE

Laboratory of Clinical Science, National Institute of Mental Health, Be-

thesda 14, Maryland

J0RI, ARMANDA


Italy

KAPLAN, NATHAN

Department of Biochemistry, Brandeis University, Waltham, Massachusetts

KASER, HANS

University of Berne, Schweiz. Zentrale f. klinischer Tumorforschung, Tiefen-

auspital, Berne, Switzerland

KAUFMAN, SEYMOUR

Laboratory of Cellular Pharmacology, National Institute of Mental Health,

Bethesda, Maryland

KETY, SEYMOUR

Laboratory of Clinical Sciences, National Institute of Mental Health, Be-

thesda, Maryland

KIRSHNER, NORMAN

Department of Biochemistry, Duke University School of Medicine, Durham,

North Carolina

KOELLE, GEORGE B.

Department of Pharmacology, University of Pennsylvania Schools of Medi-

cine, Philadelphia, Pennsylvania

KOPIN, IRWIN J.


thesda, Maryland

KREBS, E. G.

Department of Biochemistry, University of Washington, Seattle 5, Washing-

ton

KRONEBERG, GUNTHER

Farbenfabriken Bayer A. G., Leverkusen, Germany

KUNTZMAN, RONALD

Burroughs Wellcome and Co., The Wellcome Research Laboratories, 1

Scarsdale Road, Tuckahoe, New York

PARTICIPANTS 21

LA BROSSE, ELWOOD H.

Department of Surgery, University of Maryland Medical School, 29 5.

Green Street, Baltimore, Maryland

LANGEMANN, HEINRICH

Pharmakologisches Institut, University of Zurich, Gloriastrasse 32, Zurich,

Switzerland

LAPIN, I. P.

Chief Laboratory of Psychopharmacology, Bechterev Psychoneurological

Research Institute, 3 Bechterev Street, Leningrad C-19, Leningrad, USSR

LEONARDI, A.


Italy

LEVI, R.

Department of Pharmacology, University of Pisa, Via Roma 55, Pisa, Italy

LEVI MONTALCINI, R.

Department of Zoology, Washington University, St. Louis, Missouri, and

Istituto Superiore di Sanit#{224}, Roma, Italy

LEVIN, E.

Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland

LUNDHOLM, C. L.

Department of Pharmacology, University of Goteborg, G#{246}teborg, Sweden

M.AFFII, GIULIO

Lepetit S.p.A, Via Durando 38, Milano, Italy

MAITRE, LAURENT

Ciba Aktiengesellschaft, Basel, Switzerland

MALMFORS, T.

Department of Histology, Karolinska Institutet, Stockholm 60, Sweden

MANARA, LUCIANO


Italy

MANSOUR, T. E.

Department of Pharmacology, Stanford University School of Medicine,

Palo Alto, California

MANTEGAZZA, PAOLO

Istituto di Farmacologia, Universit#{224} di Milano, Via Andrea del Sarto 21,

Milano, Italy

MAN’IAI, SUSAN

Experimental Research Department of Medical University, Budapest,

Hungary

MARLEY, E.

Institute of Psychiatry, Maudsley Hospital, London S.E. 5, England

MAsuo�, DAVID

Department of Histology, Karolinska Institutet, Stockholm 60, Sweden

MAXWELL, ROBERT A.

Department of Pharmacology, University of Vermont School of Medicine,

Burlington, Vermont

22 PARTICIPANTS

MAY NERT, EVERETT W.

Department of Pharmacology, University of Illinois College of Medicine,

901 S. Walcott, P.O.B. 6998, Chicago, Illinois

MERRILLS, R. J.

Department of Pharmacology, Pfizer Limited, Sandwich, Kent, England

MICHAELSON, I. ARTHUR

Department of Pharmacology, College of Medicine, University of Cincin-


MILLER, J. W.

Department of Pharmacology, University of Minnesota, 105 Millard Hall,

Minneapolis, Minnesota

MORAN, NEIL C.

Department of Pharmacology, Emory University, Atlanta, Georgia 30322

MULLER, E.

Geigy S.A., Basel, Switzerland

MUSACCHIO, JOSE


thesda, Maryland

MUSCHOLL, E.

Pharmakologisches Institut der Universit#{228}t, Langenbeck Strasse 1, Mainz,

Germany

MUSKUS, ANTONIO

I)epartment of Pharmacology, University of Caracas, P.O. 8993, Caracas,

Venezuela

NAGATSU, TOSHIHARU

Department of Biochemistry, Faculty of Medicine, University of Nagoya,

89-203 Naruko-Danchi, 1-6 Naruko-cho, Midori-ku, Nagoya, Japan

NASH, C. W.

Department of Pharmacology, University of Alberta, Edmonton, Alberta,

Canada

NICKERSON, M.

Department of Pharmacology and Therapeutics, University of Manitoba,

Bannatyne am! Emily Sts., Winnipeg 3, Manitoba, Canada

NIKODIJEVIC, BRANISLAV

Department of Pharmacology and Toxicology, Medical Faculty, University

of Skopje, Skopje, Yugoslavia

NORBERG, K. A.

Histology Department, Karolinska Institutet, Stockholm 60, Sweden

OWMAN, CHRISTEn

Department of Anatomy, University of Lund, Biskopsgatan 7, Lund.

Sweden

PAASONEN, M. K.

Department of Pharmacology, University of Helsinki, Siltavuorenpenger

10, Helsinki, Finland

PARTICIPANTS 23

PAGE, IRVINE

Cleveland Clinic, Cleveland, Ohio

PALM, DIETER

Pharmacologisches Institut der Universit#{228}t, Ludwig-Rehn Str. 14, Frank-

furt am Main, Germany

PAOLETTI, RODOLFO

Istituto di Farmacologia, Universit#{224} di Milano, Via Andrea del Sarto 21,

Milano, Italy

PARK, CHARLES

Department of Physiology, Vanderbilt University School of Medicine,

Nashville, Tennessee

PEART, W. S.

St. 1\Iary’s Hospital, London, England

PEKKARINEN, AIM0

Department of Pharmacology, University of Turku, Kiinamyllynk 10,

Turku, Finland

PETERS, SIR RUDOLPH

Department of Biochemistry of Cambridge University, Cambridge, England

PHILIPPU, A.

Pharmakologisches Institut Klinikum Essen, Hufeland Str. 55, Essen,

Germany

PLETSCHER, ALFRED

Medical Research Department, F. Hoffmann-La Roche and Co., Ltd.,

Basle, Switzerland

POISNER, ALAN M.

Albert Einstein College of Medicine, Yeshiva University, Eastchester Road

and Morris Park Avenue, New York 61, New York

PORTER, C. C.

Merck Institute for Therapeutic Research, West Point, Pennsylvania

POTTER, L. T.

Department of Pharmacology, Harvard Medical School, 25 Shattuck

Street, Boston 15, Massachusetts

PRATESI, PIETRO

Istituto di Chimica Farmaceutica, Universit#{224} di Pavia, Pavia, Italy

RADHAKRISHNAN, A. N.

Weilcome Research Unit, Christian Medical College Hospital, Vellore,

South IndiaRALL, THEODORE W.

Department of Pharmacology, Western Reserve University School of

Medicine, Cleveland 6, Ohio

R&i�m, M. J.

School of Pharmacy, Department of Pharmacology, 29/30 Brunswick Square,

London W.C. 1, England

Roos, BJORN-ERIK

Department of Pharmacology, University of Goteborg, Goteborg SV,

Sweden

24 PARTICIPANTS

ROSELL, SUNE

Farmakologiska Institutionen, Karolinska Institutet, Stockholm 60, Sweden

ROSENGREN, E.

Department of Pharmacology, University of Lund, Lund, Sweden

RUTHVEN, C.

Department of Chemical Pathology, Queen Charlotte’s Maternity Hos-

pital, Goldhawk Road, London W. 6, England

SALMOIRAGHI, G. C.

National Institute of Mental Health, St. Elizabeth’s Hospital, Washington,

D.C.

SANDLER, M.

The Bernhard Baron Memorial Research Laboratories, Queen Charlotte’s

Maternity Hospital, London, England

SCRILD, H. 0.

Department of Pharmacology, University College, Gower Street, London

W.C. 1, England

SCHUMANN, H. J.

Pharmakologisches Institut Klinikum Essen, Hufelandstrasse 55, 43 Essen,

West Germany

SEKERIS, CONSTANTIN E.

Physiologisch-chemisches Institut der Universit#{228}t, 355 Marburg/Lahn,

Germany

SHANKS, R. G.

Pharmaceutical Division, Research Department, Imperial Chemical In-

dustries Ltd., Alderly Park, Macclesfield, Cheshire, England

SUARMAN, D. F.

Pharmacology Unit, Institute of Animal Physiology, Babraham, Cambridge,

England

SHIDEMAN, FREDERICK

Department of Pharmacology, College of Medical Sciences, University of

Minnesota, Minneapolis 14, Minnesota

SHORE, PARKURST A.

Department of Pharmacology, University of Texas, Southwestern Medical

School, 5323 Harry Hines Boulevard, Dallas, Texas

SIGO, ERNST B.

Geigy Research Laboratories, P.O. Box 430, Yonkers, New York

SJOERDSMA, ALBERT

Experimental Therapeutics Branch, National Heart Institute, Bethesda,

Maryland

SJ#{246}QVIST, F.

Department of Pharmacology, Karolinska Institutet, Stockholm 60, Sweden

SLATER, IRWIN H.

Lilly Research Laboratories, 740 South Alabama Street, Indianapolis 6,

Indiana

PARTICIPANTS 25

SMITH, A.

Department of Psychiatry, New York University, 550 First Ave., New York,

New York

SMITH, S. E.

Department of Pharmacology and Therapeutics, St. Thomas’ Hospital

Medical School, London S.E.1, England

SoLOMoN, LAWRENCE

Jewish General Hospital, 3755 Cote Street Catherine Road, Montreal,

Canada

SOURKES, THEODORE L.

Allan Memorial Institute of Psychiatry, 1025 Pine Avenue West, Montreal

2, Canada

SPECTOR, Snxr�ix

Experimental Therapeutics Branch, National Heart Institute, Bethesda,

Maryland

STARCICH, RICCARDO

Istituto di Clinica Medica, Universit#{224} di Parma, Parma, Italy

STASZEWSKA-BARCZAK, J.

Polska Akademia Nauk Zaktad Patologii Doswiadczalnej, Warsaw, ul,

Dworkowa Nr. 3, Poland

STEINBERG, DANIEL

Laboratory of Metabolism, National Heart Institute, Bethesda, Maryland

20014

STJARNE, LENNART

Department of Physiology, Karolinska Institutet, Stockholm 60, Sweden

STOCK, KLAUS

Pharmakologisches Institute der Universit#{228}t, Ludwig-Rehn Strasse, Frank-


STONE, CLEMENT

Merck Institute for Therapeutic Research, West Point, Pennsylvania

SUTHERLAND, EARL W., JR.

Vanderbilt University School of Medicine, Nashville, Tennessee

TABACHNICK, IRVING I. A.

Biochemical Pharmacology Research, Schering Corporation, Bloomfield,

New Jersey

Trrus, ELWOOD 0.

Laboratory of Chemical Pharmacology, National Heart Institute, Be-

thesda, Maryland

TRABUCCHI, EMILIO

Universit#{224} degli Studi, Istituto di Farmacologia, Via Andrea del Sarto 21,

Milano, Italy

TRENDELENBURG, U. G.

Department of Pharmacology, Harvard Medical School, 25 Shattuck Street,

Boston 15, Massachusetts

26 PARTICIPANTS

UDENFRIEND, SIDNEY

Laboratory of Clinical Biochemistry, National Heart Institute, Bethesda,

Maryland

UVNAS, BORJE

Department of Pharmacology, Karolinska Institutet, Stockholm 60, Sweden

VALDECASAS, F. G.

Department of Pharmacology, University of Barcelona, Calle Casanova 143.

Barcelona, Spain

VALZELLI, LuIGI

Istituto di Ricerche Farmacologiche “Mario Negri,” Via Eritrea, 62, Milano.

Italy

VANE, J. R.

Department of Pharmacology, Royal College of Surgeons of England.

Lincoln’s Inn Fields, London W.C. 2, England

VAN ROSSUM, J. M.

Department of Pharmacology, R. K. Universit#{228}t, Kapittelweg 40, Nijmegen,

Holland

VARAGI#{233}, VLADISLAV

Department of Pharmacology, Medical Faculty, Belgrade, Yugoslavia

VAUGHAN, MARTHA

National Institutes of Health, Bethesda, Maryland

VOGT, MARTHE

Institute of Animal Physiology, Babraham, Cambridge, England

VON STUDNITZ, W.Department of Clinical Chemistry, University of Lund, Malm#{246} General

Hospital, MalmO, Sweden

WALAAS, EVA

Institute of i\Iedical Biochemistry, University of Oslo, Oslo, Norway

WALAAS, 0.

Institute of \Iedical Biochemistry, University of Oslo, Oslo, Norway

WEIL-MALHERBE, HANS

Clinical Neuropharmacology Research Center, National Institute of Mental

Health, St. Elizabeth’s Hospital, Washington, D.C.

WEINER, NORMAN

Department of Pharmacology, Harvard 1\Iedical School, 25 Shattuck St.,

Boston 15, Massachusetts

WELCH, BRUCE L.

Department of Biology, College of William and Mary, Williamsburg,

Virginia

WENKE, M.

Department of Pharmacology, Faculty of General Medicine, Charles Uni-

versity, Prague, Czechoslovakia

WESTERMANN, ERICK

Pharmakologisches Institut der Universit#{228}t,Ludwig-Rehn Str. 14, Frank-


PARTICIPANTS 27

WHIrrAKER, V. P.

Biochemistry Department, Agricultural Research Council, Institute of

Animal Physiology, Babraham, Cambridge, England

WILLIAMSON, J. R.

Department of Biophysics and Physical Biochemistry, Johnson Research

Foundation, University of Pennsylvania, Philadelphia, Pennsylvania

WITKOP, BERNHARD

Laboratory of Chemistry, National Institute of Arthritis and 1\Ietabolic

Diseases, Bethesda, Maryland

ZAIMIS, E.

Department of Pharmacology, Royal Free Hospital School of Medicine,

8 Hunter, London, W.C.1, England

ZELLER, E. ALBERT

Department of Biochemistry, Northwestern University School of 1\Iedicine,

303 E. Chicago Ave., Chicago, Illinois

ZIEGLER, W.

University of Zurich School of Medicine, ZUrich, Switzerland

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