Blood Components -93 % RBCs -6 % Platelets -1 % WBCs

A Short Introduction To Platelet Rich Plasma Therapy

Blood Components

• Blood Components -93 % RBCs -6 % Platelets -1 % WBCs -Plasma(Liquid Component) • PRP - 94 % Platelets and Plasma - 5 % WBCs

Function of Blood Cells

Leukocytes ;Infection Removal Bacteria

Erythrocytes;Oxygen Transport

Platelets;Blood clotting and wound healing.

Platelets

• Platelets derived from megokaryocytes• Important in Hemostasis/Clotting• Platelets are normally activated during the inflammatory phase to begin healing• Role in the normal healing response via the

secrection of local growth factors• Growth factors released by platelets recruit

reparative cells and augment soft-tissue repair

What Is PRP

Platelet-rich plasma (PRP) is blood plasma that has been enriched with platelets. As a concentrated source of autologous platelets, PRP contains (and releases through degranulation) several different growth factors and other cytokines that stimulate healing of bone and soft tissue.

PRP Application Areas

• Orthopedic and Traumatology• Maxillo-Facial Surgery• Plastic/Reconstructive Surgery• Cardiac Surgery• Cosmetic Surgery• General Surgery• Sports Medicine• Hair Transplantation• Skin Rejuvanation

Platelet Growth Factors

Growth Factor

Transforing Growth Factor –BetaTGF-β

Basic Fibroblast Growth Factor,bFGF

Epidermal Growth FactorEGF

Vascular Endothelial Growth FactorVEGF

Connective Tissue Growth FactorCTGF

Sources

Platelets,extra cellular matrix of bone,Cartilage matrix,activated TH cells and natural killer cells,macrophages/monocytesAnd neutrophils.

Platelets,macrophages,mesenchymal cells,chondrocytes,osteoblasts

Platelets,macrophages,monocytes

Platelets,endothelial cells

Platelets through endocytosis from extra-Cellular environment in bone marrow.

Action of PRP Growth Factors

Healing Cascade

Platelet Count

Normal Platelet Count Concentrated Platelet Count

Cellular Factors İn Wound Healing

Benefits of PRP in the Healing Cascade

Easy PRP Kit

Advantages

• Easy to use• High concentrated PRP• Buffy Coat• Cost Effective• Simple Operation• No Contamination by Pathogens• Convenient for Office use

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