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Prova PO II - Gabriella Luiza Camargo Custos Bom (B) Médio (M) Ruim (U) manutenção -300 Bom (B) 0.99 0.007 0.002 conserto -800 Médio (M) 0 0.99 0.008 aluguel/dia -300 Ruim (U) 0 0 0.8 Dia/trabalho 150 Reparo Bom (B) Médio (M) Ruim (U) 0.972 0.028 0 ESTADO INICIAL ESTADO B M R Q B M 1 0 0 0 1 0 1 0 0 0 0 1 1 0 0 0 0 1 1 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 1 0 0 1 0 0 0 1 0 1 0 0 0 1 0 1 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 1 0 1 0 0 0 1 0 0 1 0 0 1 0 0 1 0 0 1 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 1 1 0 0 0 0 1 0 1 0 0 0 1 0 1
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Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

Jan 17, 2023

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Page 1: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

Prova PO II - Gabriella Luiza Camargo

Custos Bom (B) Médio (M) Ruim (U)manutenção -300 Bom (B) 0.99 0.007 0.002conserto -800 Médio (M) 0 0.99 0.008aluguel/dia -300 Ruim (U) 0 0 0.8

Dia/trabalho 150 Reparo Bom (B) Médio (M) Ruim (U)0.972 0.028 0

ESTADO INICIAL ESTADO FINALB M R Q B M

1 0 0 0 1 01 0 0 0 0 11 0 0 0 0 11 0 0 0 0 01 0 0 0 0 01 0 0 0 0 00 1 0 0 1 00 1 0 0 0 10 1 0 0 0 10 1 0 0 0 00 1 0 0 0 00 1 0 0 0 00 0 1 0 1 00 0 1 0 0 10 0 1 0 0 10 0 1 0 0 00 0 1 0 0 00 0 1 0 0 00 0 0 1 1 00 0 0 1 0 10 0 0 1 0 1

Page 2: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

Quebrado (Q)0.0010.0020.2

Quebrado (Q)0

ESTADO FINALR Q Conserto manutenção aluguel Probabilidade

0 0 0 0 0 0.990 0 0 0 0 0.990 0 0 -300 -300 0.991 0 0 0 0 0.991 0 0 -300 -300 0.990 1 -800 0 -600 0.990 0 0 0 0 00 0 0 0 0 00 0 0 -300 -300 01 0 0 0 0 01 0 0 -300 -300 00 1 -800 0 -600 00 0 0 0 0 00 0 0 0 0 00 0 0 -300 -300 01 0 0 0 0 01 0 0 -300 -300 00 1 -800 0 -600 00 0 -800 0 -600 0.9720 0 -800 0 -600 0.9720 0 -800 1 -900 0.972

Page 3: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

Probabilidade receita lucro0.007 0.002 0.001 150 148.50.007 0.002 0.001 150 1.050.007 0.002 0.001 150 -598.950.007 0.002 0.001 150 0.30.007 0.002 0.001 150 -599.70.007 0.002 0.001 300 -1399.70.99 0.008 0.002 150 00.99 0.008 0.002 150 148.50.99 0.008 0.002 150 -451.50.99 0.008 0.002 150 1.20.99 0.008 0.002 150 -598.80.99 0.008 0.002 300 -1399.4

0 0.8 0.2 150 00 0.8 0.2 150 00 0.8 0.2 150 -6000 0.8 0.2 150 1200 0.8 0.2 150 -4800 0.8 0.2 300 -1340

0.028 0 0 300 -1108.40.028 0 0 300 -1391.60.028 0 0 450 -1686.4

Page 4: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

MÊS DEMANDA Custo estocagem 60001 402 280

estoque inicial Produção Custo Estoque final

1

0 40 30004 00 41 30001 10 42 30000 20 43 30001 30 44 30004 40 45 30009 50 46 30016 60 47 30025 70 48 30036 80 49 30049 90 50 30064 100 51 30081 110 52 30100 120 53 30121 130 54 30144 140 55 30169 150 56 30196 160 57 30225 170 58 30256 180 59 30289 190 60 30324 200 61 30361 210 62 30400 220 63 30441 230 64 30484 240 65 30529 250 66 30576 260 67 30625 270 68 30676 280 69 30729 290 70 30784 300 71 30841 310 72 30900 320 73 30961 330 74 31024 340 75 31089 350 76 31156 36

Page 5: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

1

0 77 31225 370 78 31296 380 79 31369 390 80 31444 400 81 31521 410 82 31600 420 83 31681 430 84 31764 440 85 31849 450 86 31936 460 87 32025 470 88 32116 480 89 32209 490 90 32304 500 91 32401 510 92 32500 520 93 32601 530 94 32704 540 95 32809 550 96 32916 560 97 33025 570 98 33136 580 99 33249 590 100 33364 600 101 33481 610 102 33600 620 103 33721 630 104 33844 640 105 33969 650 106 34096 660 107 34225 670 108 34356 680 109 34489 690 110 34624 700 111 34761 710 112 34900 720 113 35041 730 114 35184 740 115 35329 750 116 35476 760 117 35625 770 118 35776 780 119 35929 790 120 36084 800 121 36241 81

Page 6: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

1

0 122 36400 820 123 36561 830 124 36724 840 125 36889 850 126 37056 860 127 37225 870 128 37396 880 129 37569 890 130 37744 900 131 37921 910 132 38100 920 133 38281 930 134 38464 940 135 38649 950 136 38836 960 137 39025 970 138 39216 980 139 39409 990 140 39604 1000 141 39801 1010 142 40000 1020 143 40201 1030 144 40404 1040 145 40609 1050 146 40816 1060 147 41025 1070 148 41236 1080 149 41449 1090 150 41664 1100 151 41881 1110 152 42100 1120 153 42321 1130 154 42544 1140 155 42769 1150 156 42996 1160 157 43225 1170 158 43456 1180 159 43689 1190 160 43924 1200 161 44161 1210 162 44400 1220 163 44641 1230 164 44884 1240 165 45129 1250 166 45376 126

Page 7: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

1

0 167 45625 1270 168 45876 1280 169 46129 1290 170 46384 1300 171 46641 1310 172 46900 1320 173 47161 1330 174 47424 1340 175 47689 1350 176 47956 1360 177 48225 1370 178 48496 1380 179 48769 1390 180 49044 1400 181 49321 1410 182 49600 1420 183 49881 1430 184 50164 1440 185 50449 1450 186 50736 1460 187 51025 1470 188 51316 1480 189 51609 1490 190 51904 1500 191 52201 1510 192 52500 1520 193 52801 1530 194 53104 1540 195 53409 1550 196 53716 1560 197 54025 1570 198 54336 1580 199 54649 1590 200 54964 1600 201 55281 1610 202 55600 1620 203 55921 1630 204 56244 1640 205 56569 1650 206 56896 1660 207 57225 1670 208 57556 1680 209 57889 1690 210 58224 1700 211 58561 171

Page 8: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

1

0 212 58900 1720 213 59241 1730 214 59584 1740 215 59929 1750 216 60276 1760 217 60625 1770 218 60976 1780 219 61329 1790 220 61684 1800 221 62041 1810 222 62400 1820 223 62761 1830 224 63124 1840 225 63489 1850 226 63856 1860 227 64225 1870 228 64596 1880 229 64969 1890 230 65344 1900 231 65721 1910 232 66100 1920 233 66481 1930 234 66864 1940 235 67249 1950 236 67636 1960 237 68025 1970 238 68416 1980 239 68809 1990 240 69204 2000 241 69601 2010 242 70000 2020 243 70401 2030 244 70804 2040 245 71209 2050 246 71616 2060 247 72025 2070 248 72436 2080 249 72849 2090 250 73264 2100 251 73681 2110 252 74100 2120 253 74521 2130 254 74944 2140 255 75369 2150 256 75796 216

Page 9: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

1

0 257 76225 2170 258 76656 2180 259 77089 2190 260 77524 2200 261 77961 2210 262 78400 2220 263 78841 2230 264 79284 2240 265 79729 2250 266 80176 2260 267 80625 2270 268 81076 2280 269 81529 2290 270 81984 2300 271 82441 2310 272 82900 2320 273 83361 2330 274 83824 2340 275 84289 2350 276 84756 2360 277 85225 2370 278 85696 2380 279 86169 2390 280 86644 2400 281 87121 2410 282 87600 2420 283 88081 2430 284 88564 2440 285 89049 2450 286 89536 2460 287 90025 2470 288 90516 2480 289 91009 2490 290 91504 2500 291 92001 2510 292 92500 2520 293 93001 2530 294 93504 2540 295 94009 2550 296 94516 2560 297 95025 2570 298 95536 2580 299 96049 2590 300 96564 2600 301 97081 261

Page 10: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

1

0 302 97600 2620 303 98121 2630 304 98644 2640 305 99169 2650 306 99696 2660 307 100225 2670 308 100756 2680 309 101289 2690 310 101824 2700 311 102361 2710 312 102900 2720 313 103441 2730 314 103984 2740 315 104529 2750 316 105076 2760 317 105625 2770 318 106176 2780 319 106729 2790 320 107284 280

2

0 280 93504 01 279 93001 02 278 92500 03 277 92001 04 276 91504 05 275 91009 06 274 90516 07 273 90025 08 272 89536 09 271 89049 0

10 270 88564 011 269 88081 012 268 87600 013 267 87121 014 266 86644 015 265 86169 016 264 85696 017 263 85225 018 262 84756 019 261 84289 020 260 83824 021 259 83361 022 258 82900 023 257 82441 024 256 81984 025 255 81529 0

Page 11: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

2

26 254 81076 027 253 80625 028 252 80176 029 251 79729 030 250 79284 031 249 78841 032 248 78400 033 247 77961 034 246 77524 035 245 77089 036 244 76656 037 243 76225 038 242 75796 039 241 75369 040 240 74944 041 239 74521 042 238 74100 043 237 73681 044 236 73264 045 235 72849 046 234 72436 047 233 72025 048 232 71616 049 231 71209 050 230 70804 051 229 70401 052 228 70000 053 227 69601 054 226 69204 055 225 68809 056 224 68416 057 223 68025 058 222 67636 059 221 67249 060 220 66864 061 219 66481 062 218 66100 063 217 65721 064 216 65344 065 215 64969 066 214 64596 067 213 64225 068 212 63856 069 211 63489 070 210 63124 0

Page 12: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

2

71 209 62761 072 208 62400 073 207 62041 074 206 61684 075 205 61329 076 204 60976 077 203 60625 078 202 60276 079 201 59929 080 200 59584 081 199 59241 082 198 58900 083 197 58561 084 196 58224 085 195 57889 086 194 57556 087 193 57225 088 192 56896 089 191 56569 090 190 56244 091 189 55921 092 188 55600 093 187 55281 094 186 54964 095 185 54649 096 184 54336 097 183 54025 098 182 53716 099 181 53409 0

100 180 53104 0101 179 52801 0102 178 52500 0103 177 52201 0104 176 51904 0105 175 51609 0106 174 51316 0107 173 51025 0108 172 50736 0109 171 50449 0110 170 50164 0111 169 49881 0112 168 49600 0113 167 49321 0114 166 49044 0115 165 48769 0

Page 13: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

2

116 164 48496 0117 163 48225 0118 162 47956 0119 161 47689 0120 160 47424 0121 159 47161 0122 158 46900 0123 157 46641 0124 156 46384 0125 155 46129 0126 154 45876 0127 153 45625 0128 152 45376 0129 151 45129 0130 150 44884 0131 149 44641 0132 148 44400 0133 147 44161 0134 146 43924 0135 145 43689 0136 144 43456 0137 143 43225 0138 142 42996 0139 141 42769 0140 140 42544 0141 139 42321 0142 138 42100 0143 137 41881 0144 136 41664 0145 135 41449 0146 134 41236 0147 133 41025 0148 132 40816 0149 131 40609 0150 130 40404 0151 129 40201 0152 128 40000 0153 127 39801 0154 126 39604 0155 125 39409 0156 124 39216 0157 123 39025 0158 122 38836 0159 121 38649 0160 120 38464 0

Page 14: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

2

161 119 38281 0162 118 38100 0163 117 37921 0164 116 37744 0165 115 37569 0166 114 37396 0167 113 37225 0168 112 37056 0169 111 36889 0170 110 36724 0171 109 36561 0172 108 36400 0173 107 36241 0174 106 36084 0175 105 35929 0176 104 35776 0177 103 35625 0178 102 35476 0179 101 35329 0180 100 35184 0181 99 35041 0182 98 34900 0183 97 34761 0184 96 34624 0185 95 34489 0186 94 34356 0187 93 34225 0188 92 34096 0189 91 33969 0190 90 33844 0191 89 33721 0192 88 33600 0193 87 33481 0194 86 33364 0195 85 33249 0196 84 33136 0197 83 33025 0198 82 32916 0199 81 32809 0200 80 32704 0201 79 32601 0202 78 32500 0203 77 32401 0204 76 32304 0205 75 32209 0

Page 15: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

2

206 74 32116 0207 73 32025 0208 72 31936 0209 71 31849 0210 70 31764 0211 69 31681 0212 68 31600 0213 67 31521 0214 66 31444 0215 65 31369 0216 64 31296 0217 63 31225 0218 62 31156 0219 61 31089 0220 60 31024 0221 59 30961 0222 58 30900 0223 57 30841 0224 56 30784 0225 55 30729 0226 54 30676 0227 53 30625 0228 52 30576 0229 51 30529 0230 50 30484 0231 49 30441 0232 48 30400 0233 47 30361 0234 46 30324 0235 45 30289 0236 44 30256 0237 43 30225 0238 42 30196 0239 41 30169 0240 40 30144 0241 39 30121 0242 38 30100 0243 37 30081 0244 36 30064 0245 35 30049 0246 34 30036 0247 33 30025 0248 32 30016 0249 31 30009 0250 30 30004 0

Page 16: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

2

251 29 30001 0252 28 30000 0253 27 30001 0254 26 30004 0255 25 30009 0256 24 30016 0257 23 30025 0258 22 30036 0259 21 30049 0260 20 30064 0261 19 30081 0262 18 30100 0263 17 30121 0264 16 30144 0265 15 30169 0266 14 30196 0267 13 30225 0268 12 30256 0269 11 30289 0270 10 30324 0271 9 30361 0272 8 30400 0273 7 30441 0274 6 30484 0275 5 30529 0276 4 30576 0277 3 30625 0278 2 30676 0279 1 30729 0280 0 30784 0

Page 17: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

mês 1Custo estoque Custo total Estoque final Produção total(MIL

0 30004 0 40 300046000 36001 1 41 36001

12000 42000 2 42 4200018000 48001 3 43 4800124000 54004 4 44 5400430000 60009 5 45 6000936000 66016 6 46 6601642000 72025 7 47 7202548000 78036 8 48 7803654000 84049 9 49 8404960000 90064 10 50 9006466000 96081 11 51 9608172000 102100 12 52 10210078000 108121 13 53 10812184000 114144 14 54 11414490000 120169 15 55 12016996000 126196 16 56 126196102000 132225 17 57 132225108000 138256 18 58 138256114000 144289 19 59 144289120000 150324 20 60 150324126000 156361 21 61 156361132000 162400 22 62 162400138000 168441 23 63 168441144000 174484 24 64 174484150000 180529 25 65 180529156000 186576 26 66 186576162000 192625 27 67 192625168000 198676 28 68 198676174000 204729 29 69 204729180000 210784 30 70 210784186000 216841 31 71 216841192000 222900 32 72 222900198000 228961 33 73 228961204000 235024 34 74 235024210000 241089 35 75 241089216000 247156 36 76 247156

Page 18: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

222000 253225 37 77 253225228000 259296 38 78 259296234000 265369 39 79 265369240000 271444 40 80 271444246000 277521 41 81 277521252000 283600 42 82 283600258000 289681 43 83 289681264000 295764 44 84 295764270000 301849 45 85 301849276000 307936 46 86 307936282000 314025 47 87 314025288000 320116 48 88 320116294000 326209 49 89 326209300000 332304 50 90 332304306000 338401 51 91 338401312000 344500 52 92 344500318000 350601 53 93 350601324000 356704 54 94 356704330000 362809 55 95 362809336000 368916 56 96 368916342000 375025 57 97 375025348000 381136 58 98 381136354000 387249 59 99 387249360000 393364 60 100 393364366000 399481 61 101 399481372000 405600 62 102 405600378000 411721 63 103 411721384000 417844 64 104 417844390000 423969 65 105 423969396000 430096 66 106 430096402000 436225 67 107 436225408000 442356 68 108 442356414000 448489 69 109 448489420000 454624 70 110 454624426000 460761 71 111 460761432000 466900 72 112 466900438000 473041 73 113 473041444000 479184 74 114 479184450000 485329 75 115 485329456000 491476 76 116 491476462000 497625 77 117 497625468000 503776 78 118 503776474000 509929 79 119 509929480000 516084 80 120 516084486000 522241 81 121 522241

Page 19: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

492000 528400 82 122 528400498000 534561 83 123 534561504000 540724 84 124 540724510000 546889 85 125 546889516000 553056 86 126 553056522000 559225 87 127 559225528000 565396 88 128 565396534000 571569 89 129 571569540000 577744 90 130 577744546000 583921 91 131 583921552000 590100 92 132 590100558000 596281 93 133 596281564000 602464 94 134 602464570000 608649 95 135 608649576000 614836 96 136 614836582000 621025 97 137 621025588000 627216 98 138 627216594000 633409 99 139 633409600000 639604 100 140 639604606000 645801 101 141 645801612000 652000 102 142 652000618000 658201 103 143 658201624000 664404 104 144 664404630000 670609 105 145 670609636000 676816 106 146 676816642000 683025 107 147 683025648000 689236 108 148 689236654000 695449 109 149 695449660000 701664 110 150 701664666000 707881 111 151 707881672000 714100 112 152 714100678000 720321 113 153 720321684000 726544 114 154 726544690000 732769 115 155 732769696000 738996 116 156 738996702000 745225 117 157 745225708000 751456 118 158 751456714000 757689 119 159 757689720000 763924 120 160 763924726000 770161 121 161 770161732000 776400 122 162 776400738000 782641 123 163 782641744000 788884 124 164 788884750000 795129 125 165 795129756000 801376 126 166 801376

Page 20: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

762000 807625 127 167 807625768000 813876 128 168 813876774000 820129 129 169 820129780000 826384 130 170 826384786000 832641 131 171 832641792000 838900 132 172 838900798000 845161 133 173 845161804000 851424 134 174 851424810000 857689 135 175 857689816000 863956 136 176 863956822000 870225 137 177 870225828000 876496 138 178 876496834000 882769 139 179 882769840000 889044 140 180 889044846000 895321 141 181 895321852000 901600 142 182 901600858000 907881 143 183 907881864000 914164 144 184 914164870000 920449 145 185 920449876000 926736 146 186 926736882000 933025 147 187 933025888000 939316 148 188 939316894000 945609 149 189 945609900000 951904 150 190 951904906000 958201 151 191 958201912000 964500 152 192 964500918000 970801 153 193 970801924000 977104 154 194 977104930000 983409 155 195 983409936000 989716 156 196 989716942000 996025 157 197 996025948000 1002336 158 198 1002336954000 1008649 159 199 1008649960000 1014964 160 200 1014964966000 1021281 161 201 1021281972000 1027600 162 202 1027600978000 1033921 163 203 1033921984000 1040244 164 204 1040244990000 1046569 165 205 1046569996000 1052896 166 206 1052896

1002000 1059225 167 207 10592251008000 1065556 168 208 10655561014000 1071889 169 209 10718891020000 1078224 170 210 10782241026000 1084561 171 211 1084561

Page 21: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

1032000 1090900 172 212 10909001038000 1097241 173 213 10972411044000 1103584 174 214 11035841050000 1109929 175 215 11099291056000 1116276 176 216 11162761062000 1122625 177 217 11226251068000 1128976 178 218 11289761074000 1135329 179 219 11353291080000 1141684 180 220 11416841086000 1148041 181 221 11480411092000 1154400 182 222 11544001098000 1160761 183 223 11607611104000 1167124 184 224 11671241110000 1173489 185 225 11734891116000 1179856 186 226 11798561122000 1186225 187 227 11862251128000 1192596 188 228 11925961134000 1198969 189 229 11989691140000 1205344 190 230 12053441146000 1211721 191 231 12117211152000 1218100 192 232 12181001158000 1224481 193 233 12244811164000 1230864 194 234 12308641170000 1237249 195 235 12372491176000 1243636 196 236 12436361182000 1250025 197 237 12500251188000 1256416 198 238 12564161194000 1262809 199 239 12628091200000 1269204 200 240 12692041206000 1275601 201 241 12756011212000 1282000 202 242 12820001218000 1288401 203 243 12884011224000 1294804 204 244 12948041230000 1301209 205 245 13012091236000 1307616 206 246 13076161242000 1314025 207 247 13140251248000 1320436 208 248 13204361254000 1326849 209 249 13268491260000 1333264 210 250 13332641266000 1339681 211 251 13396811272000 1346100 212 252 13461001278000 1352521 213 253 13525211284000 1358944 214 254 13589441290000 1365369 215 255 13653691296000 1371796 216 256 1371796

Page 22: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

1302000 1378225 217 257 13782251308000 1384656 218 258 13846561314000 1391089 219 259 13910891320000 1397524 220 260 13975241326000 1403961 221 261 14039611332000 1410400 222 262 14104001338000 1416841 223 263 14168411344000 1423284 224 264 14232841350000 1429729 225 265 14297291356000 1436176 226 266 14361761362000 1442625 227 267 14426251368000 1449076 228 268 14490761374000 1455529 229 269 14555291380000 1461984 230 270 14619841386000 1468441 231 271 14684411392000 1474900 232 272 14749001398000 1481361 233 273 14813611404000 1487824 234 274 14878241410000 1494289 235 275 14942891416000 1500756 236 276 15007561422000 1507225 237 277 15072251428000 1513696 238 278 15136961434000 1520169 239 279 15201691440000 1526644 240 280 15266441446000 1533121 241 281 15331211452000 1539600 242 282 15396001458000 1546081 243 283 15460811464000 1552564 244 284 15525641470000 1559049 245 285 15590491476000 1565536 246 286 15655361482000 1572025 247 287 15720251488000 1578516 248 288 15785161494000 1585009 249 289 15850091500000 1591504 250 290 15915041506000 1598001 251 291 15980011512000 1604500 252 292 16045001518000 1611001 253 293 16110011524000 1617504 254 294 16175041530000 1624009 255 295 16240091536000 1630516 256 296 16305161542000 1637025 257 297 16370251548000 1643536 258 298 16435361554000 1650049 259 299 16500491560000 1656564 260 300 16565641566000 1663081 261 301 1663081

Page 23: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

1572000 1669600 262 302 16696001578000 1676121 263 303 16761211584000 1682644 264 304 16826441590000 1689169 265 305 16891691596000 1695696 266 306 16956961602000 1702225 267 307 17022251608000 1708756 268 308 17087561614000 1715289 269 309 17152891620000 1721824 270 310 17218241626000 1728361 271 311 17283611632000 1734900 272 312 17349001638000 1741441 273 313 17414411644000 1747984 274 314 17479841650000 1754529 275 315 17545291656000 1761076 276 316 17610761662000 1767625 277 317 17676251668000 1774176 278 318 17741761674000 1780729 279 319 17807291680000 1787284 280 320 1787284

0 1235080 1290020 1345000 1400020 1455080 1510180 1565320 1620500 1675720 1730980 1786280 1841620 1897000 1952420 2007880 2063380 2118920 2174500 2230120 2285780 2341480 2397220 2453000 2508820 2564680 262058

Page 24: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

0 2676520 2732500 2788520 2844580 2900680 2956820 3013000 3069220 3125480 3181780 3238120 3294500 3350920 3407380 3463880 3520420 3577000 3633620 3690280 3746980 3803720 3860500 3917320 3974180 4031080 4088020 4145000 4202020 4259080 4316180 4373320 4430500 4487720 4544980 4602280 4659620 4717000 4774420 4831880 4889380 4946920 5004500 5062120 5119780 517748

Page 25: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

0 5235220 5293000 5350820 5408680 5466580 5524520 5582500 5640520 5698580 5756680 5814820 5873000 5931220 5989480 6047780 6106120 6164500 6222920 6281380 6339880 6398420 6457000 6515620 6574280 6632980 6691720 6750500 6809320 6868180 6927080 6986020 7045000 7104020 7163080 7222180 7281320 7340500 7399720 7458980 7518280 7577620 7637000 7696420 7755880 781538

Page 26: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

0 7874920 7934500 7994120 8053780 8113480 8173220 8233000 8292820 8352680 8412580 8472520 8532500 8592520 8652580 8712680 8772820 8833000 8893220 8953480 9013780 9074120 9134500 9194920 9255380 9315880 9376420 9437000 9497620 9558280 9618980 9679720 9740500 9801320 9862180 9923080 9984020 10045000 10106020 10167080 10228180 10289320 10350500 10411720 10472980 1053428

Page 27: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

0 10595620 10657000 10718420 10779880 10841380 10902920 10964500 11026120 11087780 11149480 11211220 11273000 11334820 11396680 11458580 11520520 11582500 11644520 11706580 11768680 11830820 11893000 11955220 12017480 12079780 12142120 12204500 12266920 12329380 12391880 12454420 12517000 12579620 12642280 12704980 12767720 12830500 12893320 12956180 13019080 13082020 13145000 13208020 13271080 1333418

Page 28: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

0 13397320 13460500 13523720 13586980 13650280 13713620 13777000 13840420 13903880 13967380 14030920 14094500 14158120 14221780 14285480 14349220 14413000 14476820 14540680 14604580 14668520 14732500 14796520 14860580 14924680 14988820 15053000 15117220 15181480 15245780 15310120 15374500 15438920 15503380 15567880 15632420 15697000 15761620 15826280 15890980 15955720 16020500 16085320 16150180 1621508

Page 29: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

0 16280020 16345000 16410020 16475080 16540180 16605320 16670500 16735720 16800980 16866280 16931620 16997000 17062420 17127880 17193380 17258920 17324500 1739012 10 1745578 10 1752148 20 1758722 20 1765300 20 1771882 30 17784680 17850580 17916520 17982500 18048520 18114580 1818068

Page 30: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

mês 2Estoque finalProdução total(MIL)

0 280 123508

Produzirmês 1 30004 40 milmês 2 123508 280 mil

Page 31: Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method

1 12 23 104 35 1

1 2 6 22 3 7 53 12 8 99 8 9 68 11 10 9

10 12