Beta Oxidation Part I e break down of a fatty acid to acetyl- units…the ‘glycolysis’ of fatty acids Occurs in the mitochondria Exemplifies Aerobic Metabolism at its most powerful phase STRICTLY AEROBIC cetyl-CoA is fed directly into the Krebs cyc Overproduction causes KETOSIS
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Beta Oxidation Part I The break down of a fatty acid to acetyl-CoA units…the ‘glycolysis’ of fatty acids Occurs in the mitochondria Exemplifies Aerobic.
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Beta Oxidation Part IThe break down of a fatty acid to acetyl-CoA
units…the ‘glycolysis’ of fatty acids
Occurs in the mitochondria
Exemplifies Aerobic Metabolism
at its most powerful phase
STRICTLY AEROBIC
Acetyl-CoA is fed directly into the Krebs cycle
Overproduction causes KETOSIS
Schedule of Topics
• Digestion, absorption and transport
• General mechanism of fatty acid oxidation
• Oxidation of unsaturated fatty acids
• Odd chain fatty acids…role of vitamin B12
• Ketone bodies and ketosis
Fatty Acid OxidationFatty Acid Oxidation
CH3CH2CH2COOH
[CH3CH2CH2CO-AMP]
CH3CH2CH2CO~SCoA
HS-CoA
Fatty acyl CoA
ATP
PPi
AMPFatty acylCoA Ligase
Prepares a Fatty Acid for transport and metabolism