Glucose Glucose Glutamine Glucose-6P Glucose-6P Glycerol-3P Fatty Acids Glutamate Ribose-5P 2 NADP+ NADP+ NADP+ Acetyl-CoA α-KG ETC Malate Fructose-6P Fructose-1,6-P 2 1,3-Biphosphoglycerate 3-Phosphoglycerate 2-Phosphoglycerate Phosphoenolpyruvate Pyruvate Pyruvate Glyceraldehyde-3P Dihydroxyacetone-P PI3K PI3K PI3K MYC MYC MYC NUCLEOTIDE SYNTHESIS NUCLEOTIDE SYNTHESIS LIPID SYNTHESIS HIF p53 p53 Lactate p53 P AMPK AMPK 2 NADPH 2 NADPH 2 NADPH HIF HIF-1 p53 HIF HIF HIF HIF MYC HIF Aldolase Glutaminase GLUT1 Hexokinase Hexokinase 2 Pyruvate Kinase Phosphofructokinase Phosphoglucomutase Enolase Pyruvate Kinase Phosphoglucose Isomerase Phosphoglycerate Kinase Triosephosphate Isomerase Fatty Acid Synthase ATP Citrate Lyase Pyruvate Dehydrogenase Lactate Dehydrogenase A 13 B Glyceraldehyde-3- phosphate Dehydrogenase Pyruvate Dehydrogenase Kinase 1 Carnitine Palmitoy- ltransferase 1 Glucose Transporter 1 ROS Acetyl-CoA Acetyl-CoA α -Ketoglutarate FATTY ACID SYNTHESIS Electron Transport Chain MYC MYC MYC HIF HIF HIF Aconitase 2 Citrate Synthase Pyruvate Dehydrogenase α-Ketoglutarate Dehydrogenase Lactate Dehydrogenase Fatty Acid Synthase Pyruvate Dehydrogenase Kinase 1 C A A Carnitine Palmitoy- ltransferase 1 ROS LIPID SYNTHESIS LIPID SYNTHESIS Pyruvate Oxaloacetate Citrate Isocitrate Glutamate Glutamine α-Ketoglutarate Dehydr oge na Succinyl-CoA Succinate Citrate Pyruvate Lactate Glutaminase 2HG Malate Fumarate Malate Succinyl-CoA Ligase Malic Enzyme 1 e Malate Dehydrogenase Mutant Fumarate Hydratase Mutant Isocitrate Dehydrogenase 2 Mutant Isocitrate Dehydrogenase 1 Mutant Succinate Dehydrogenase TCA Cycle Citrate at abcam.com/cancer Copyright © 2014 Abcam, All Rights Reserved. The Abcam logo is a registered trademark. All information / detail is correct at time of going to print. Produced in collaboration with Meghan Verschoor (McMaster University, Hamilton, Ontario, Canada). Kits Size Description Species Product reactivity code MitoProfile® Total OXPHOS Human 360 or 720 μg The cocktail is suitable for Western Blotting Hu ab110411 WB Antibody Cocktail analysis of the relative levels of the 5 OXPHOS complexes in mitochondrial preparations MitoProfile® Total OXPHOS Rodent 360 or 720 μg The cocktail is suitable for Western Blotting Ms, Rt ,Hu, ab110413 WB Antibody Cocktail analysis of the relative levels of the 5 OXPHOS Cow, Mk complexes in mitochondrial preparations ATP citrate lyase (ab40793) Clonality Applications Host Species cross reactivity M WB, IP, ELISA, Rb Hu, Ms, Rt IHC-P, ICC/IF c-Myc (ab32072) Clonality Applications Host Species cross reactivity M WB, IP, IHC-P, ICC/IF Rb Hu, Ms, Rt Glucose Transporter GLUT1 (ab115730) Clonality Applications Host Species cross reactivity M WB, IHC-P, Flow Cyt, Rb Hu, Ms, Rt ICC/IF p53 (ab26) Clonality Applications Host Species cross reactivity M WB, IP, IHC-Fr, IHC-P, Ms Hs, Ms, Rt, Chk, Cow, Flow Cyt, ICC/IF CMk, Dog, Hm, Dog, Hm Pyrovate Dehydrogenase E2 (ab66511) Clonality Applications Host Species cross reactivity P ELISA, IHC-P, WB Rb Hu, Ms, Rt, Dog Aconitase 2 [6F12BD9] M Flow Cyt, ICC/IF , In-Cell ELISA, IP , WB Ms Hu, Rt, Dm ab110321 AMPK alpha 1 + AMPK alpha 2 M WB, IP, ELISA, IHC-Fr, ICC/IF Ms Hu, Rt, Dm ab80039 c-Myc [9E10] - ChIP Grade ChIP, ELISA, Flow Cyt, ICC, ICC/IF, IHC (Methanol fixed), IHC-Fr, IHC-P, M IP, Purification, WB Ms Hu, Ms, Dm ab32 Fatty Acid Synthase P ICC/IF , IHC (PFA fixed), IHC-Fr, IP , WB Rb Hu, Ms, Rt ab22759 Glucose Transporter GLUT1 P WB, IP, IHC-P, ICC/IF Rb Hu, Ms, Rt ab32551 Hexokinase II P ELISA, IHC-P, WB Rb Hu ab37593 HIF1 alpha M WB, IP, IHC-P, Flow Cyt, ICC/IF Rb Hu ab51608 Lactate Dehydrogenase M WB, IP, IHC-P, Flow Cyt, ICC/IF Rb Hs, Ms, Rt ab52488 Mitochondrial Pyruvate dehydrogenase kinase 1 P WB, IP, IHC-P, ICC/IF Rb Hu, Ms, Rt ab92959 p53 WB, IP, ELISA, IHC-Fr, IHC-P, M Flow Cyt, ICC/IF Ms Hu, Rt, ab28 PFKL M WB, Flow Cyt, ICC/IF Rb Hs, Ms, Rt ab181064 Pyruvate Dehydrogenase E2 Hu, Ms, M WB, IHC-P, Flow Cyt, ICC/IF Ms Rt, Cow ab110333 GAPDH P WB, IP , ELISA, IHC-Fr, Flow Cyt, ICC/IF Rb Hs, Ms, Rt, Ckn, ab9485 AGMk, XI, Sc, Sp And for superb IF and ICC results use our pre-adsorbed secondary antibodies Available conjugated to: Alexa Fluor ® 405, Alexa Fluor ® 488, Alexa Fluor ® 555, Alexa Fluor ® 568, Alexa Fluor ® 594, Alexa Fluor ® 647, Alexa Fluor ® 750 Key MitoScience Rat - Rt Chicken - Chk Saccharomyces cerevisiae - Sc RabMAb Cow-Cow Xenopus laevis - XI Saccharomyces pombe - Sp Human - Hu Dog - Dog Syrian hamster - Hm Drosophila melanogaster - Dm Mouse - Ms Monkey - Mk Cynomolgus Monkey - CMk African Green Monkey - AGMk Antibody Clonality Applications Host Species Product reactivity code DyLight® is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. Biochemicals Size Description Product code Diclofenac Sodium 1g Potent cyclo-oxygenase inhibitor ab120621 FCCP 10mg,50mg Mitochondrial oxidative phosphorylation inhibitor ab120081 Lovastatin 10mg,50mg Potent HMG CoA reductase inhibitor ab120614 NS 398 10mg,50mg COX-2 inhibitor ab120295 Product highlights