Abbrevations Autoantibodies Guidelines for diagnostic evaluation of autoimmune diseases ANA ds-DNA ss-DNA Histone Nucleosome ENA RNP Sm SS-A SS-B Scl-70 Jo-1 Centromere Ribosomal P PM-Scl PCNA RF Waaler-Rose CCP ANCA MPO PR-3 Lactoferrin BP1 GS-ANA GBM TBM Cardiolipin ß-2 GP1 LA anti-C1q AMA SMA LKM SLA ASCA Endothelium Reticulin APCA Striated muscle Cardiac muscle Coombs Thrombocyte TPO HTG TSH receptor ICA Adrenal (gland) Steroid cell Sperm EMA-IgA EMA-IgG tTG-IgA tTG-IgG Gliadin IgA Gliadin IgG Pemphigus (IC) BMZ AChR Parathyroid Systemic autoimmune diseases Active SLE • • • • Inactive SLE • • • Discoid LE Subacute cutaneous LE Drug-induced lupus • • Neonatal LE • • MCTD / Sharp syndrome • PSS • CREST syndrome • Raynaud syndrome PM / DM • PM / Scl overlap • UCTD RA adult • • • Felty syndrome • • • • JCA Sjögren syndrome • Polyarthritis nodosa Primary APS • • Wegener’s granulomatosis • • Vasculitis Churg-Strauss syndrome Micropolyangiitis Arthritis, arthralgia Myalgia Hermatological diseases HUVS • AIHA Pernicious anemia • ITP Cryoglobulinemia Autoimm. thrombosis • • • Gastrointestinal diseases Atrophic gastritis Celiac disease • • Celiac (IgA-deficient) • • • Crohn’s disease Ulcerative colitis Liver diseases CAH • CAH / HBsAg positive CAH / HCV positive Viral hepatitis Drug induced hepatitis PBC • PSC PBC / PSC overlap syndrome Renal diseases Goodpasture syndrome • RPGN Interstitial nephritis Lupus nephritis • • • • • Hematuria, proteinuria Postinfection GN Cardiovascular diseases Endocarditis lenta Pericarditis Dressler syndrome Endocrine diseases IDDM (new diagnosis) • Hashimoto’s thyroiditis • Grave’s disease • Hypoparathyroidism Hyperthyroidism Hypothyroidism Autoimmune PEP I/II Addison’s disease • • Fertility problems Habitual abortion Skin diseases Pemphigus • Pemphigoid • Alopecia Vitiligo Dermatitis herpetiformis • Neurological diseases Myasthenia gravis • Periferal neuropathy >90% • 50-90% • 30-50% • 10-30% • <10% Frequency Diagnostic Marker Legend AChR acetylcholine receptor AIHA autoimmune hemolytic anemia AMA antimitochondrial antibodies ANA antinuclear antibodies ANCA antineutrophil cytoplasmic antibodies APCA gastric parietal cell antibodies APS antiphospholipid syndrome ASCA anti-Saccharomyces cerevisiae antibody BMZ basal membrane zone BPI bactericidal permeability-increasing protein ß-2 GP1 beta-2 glycoprotein I CAH chronic autoimmune hepatitis CCP cyclic citrullinated peptides CREST calcinosis, Raynaud phenomenon, oesophagus dismotility, sclerodactyly, teleargiectasia C1q complement protein DIL drug induced lupus DM dermatomyositis ds-DNA double stranded DNA EMA endomysium antibody ENA extractable nuclear antibody GBM glomerular basal membrane GN glomerulonephritis GS-ANA granulocyte-specific ANA HBsAg hepatitis B virus antigen HCV hepatitis C virus HTG human thyroglobulin HUVS hypocomplementemic urticarial vasculitis syndrome IC intercellular ICA islet cell antibody IDDM insulin dependent diabetes mellitus ITP idiopathic thrombocytopenia JCA juvenile chronic arthritis Jo-1 PM/DM antigen LA lupus anticoagulant LE lupus erythematosus LKM liver-kidney microsomal antibody MCTD mixed connective tissue disease MPO myeloperoxidase PBC primary biliary cirrhosis PCNA proliferating cell nuclearantigen PEP polyendocrinopathy PM polymyositis PR-3 proteinase 3 PSC primary sclerotic cholangitis PSS progressive systemic sclerosis RA rheumatoid arthritis RF rheumatoid factor RNP ribonucleoprotein RPGN rapid progressive glomerulonephritis Scl scleroderma Scl-70 scleroderma antigen (70kD) SLA soluble liver antigen SLE systemic lupus erythematosus Sm Smith antigen SMA smooth muscle antibody SS-A Sjögren’s syndrome A antigen SS-B Sjögren’s syndrome B antigen ss-DNA single-stranded DNA TBM tubular basal membrane TPO thyroidperoxidase TSH thyroid stimulating hormone tTG tissue transglutaminase UCTD undifferentiated connective tissue disease Diagnosis Autoantibody Map Edited by: Julianna Németh MD and Katalin Miklós PhD, National Medical Centre, Department of Immundiagnostics, Budapest, Hungary Guidelines for diagnostic evaluation of autoimmune diseases © HYCOR Biomedical, Inc., 2010 P/N A60051 Rev. 7/10 www.hycorbiomedical.com