AP Biology 2008-2009 Regulating the Internal Environment.

2008-2009 AP Biology

Regulating the InternalEnvironment

AP Biology

Conformers vs. Regulators Two evolutionary paths for organisms

______________________________________ maintain relatively constant internal conditions

______________________________________ allow internal conditions to fluctuate along with external changes

conformer

thermoregulation

regulator

conformer

osmoregulation

regulator

AP Biology

Homeostasis Keeping the balance

animal body needs to coordinate many systems all at once temperature blood sugar levels energy production water balance & intracellular waste disposal nutrients ion balance cell growth

maintaining a “steady state” condition



Water Balance & Nitrogenous Waste

Removal

AP Biology

intracellular waste

extracellular waste

Animal systems evolved to support multicellular life

O2

CHO

CHO

aa

aa

CH

CO2

NH3aa

O2

CH

O2

aa

CO2

CO2

CO2

CO2

CO2

CO2 CO2

CO2

CO2

CO2

NH3

NH3 NH3

NH3

NH3

NH3

NH3NH3

O2

aa

CH

aa

CHO

O2

Diffusion too slow!

AP Biology

Overcoming limitations of diffusion Evolution of exchange systems for

distributing nutrients _________________

removing wastes _________________

systems to support multicellular organisms

systems to support multicellular organisms

aa

CO2

CO2

CO2

CO2

CO2

CO2 CO2

CO2

CO2

CO2

NH3

NH3 NH3

NH3

NH3

NH3

NH3NH3

O2

aa

CH

aa

CHO

O2

AP Biology

Osmoregulation

Why do all land animals have to conserve water?

Water balance freshwater

_________________ water flow into cells & salt loss

saltwater _________________ water loss from cells

land dry environment need to conserve water may also need to conserve salt

hypotonic

hypertonic

AP Biology

Intracellular Waste What waste products?

what do we digest our food into… carbohydrates = CHO lipids = CHO proteins = CHON nucleic acids = CHOPN

CO2 + H2O

NH2 =

ammonia

CO2 + H2O CO2 + H2O

CO2 + H2O + N

CO2 + H2O + P + N

|

| ||H

HN C–OH

O

R

H–C–

Animalspoison themselves

from the insideby digesting

proteins!

lots!verylittle

cellular digestion…cellular waste

AP Biology

Nitrogenous waste disposal Ammonia (NH3)

______________________ carcinogenic

______________________ easily crosses membranes

must dilute it & get rid of it… fast!

How you get rid of nitrogenous wastes depends on who you are (evolutionary relationship) where you live (habitat)

aquatic terrestrial terrestrial egg layer

AP Biology

Nitrogen waste ____________________

can afford to lose water _________________

most toxic

____________________ need to conserve

water _________________

less toxic

________________ ________________

need to conserve water need to protect

embryo in egg _________________

least toxic

AP Biology

Freshwater animals Water removal & nitrogen waste disposal

remove surplus water use surplus water to dilute ammonia & excrete it

need to excrete a lot of water so dilute ammonia & excrete it as very dilute urine

also diffuse ammonia continuously through gills or through any moist membrane

overcome loss of salts reabsorb in kidneys or active transport across gills

AP Biology

Land animals Nitrogen waste disposal on land

need to conserve water must process ammonia so less toxic

_____ = larger molecule = less soluble = less toxic 2NH2 + CO2 = urea produced in liver

_______________ filter solutes out of blood reabsorb H2O (+ any useful solutes) excrete waste

_____ = urea, salts, excess sugar & H2O urine is very concentrated concentrated NH3 would be too toxic

OC

HNH

HNH

Ureacosts energyto synthesize,

but it’s worth it!

mammals

AP Biology

Egg-laying land animals

itty bittyliving space!

QuickTime™ and aTIFF (Uncompressed) decompressor

are needed to see this picture.

Nitrogen waste disposal in egg no place to get rid of waste in egg need even less soluble molecule

_________ = BIGGER = less soluble = less toxic birds, reptiles, insects

AP Biology

N

N N

N

O

HO

O

H

HH

Uric acidAnd that folks,

is why a male birddoesn’t have

a penis! Polymerized urea large molecule __________________________

doesn’t harm embryo in eggwhite dust in egg

adults excrete N waste as white pasteno liquid wasteurea = white bird “poop”!

AP Biology

Mammalian System Filter solutes out of blood &

reabsorb H2O + desirable solutes Key functions

____________________ fluids (water & solutes) filtered out

of blood ____________________

selectively reabsorb (diffusion) needed water + solutes back to blood

____________________ pump out any other unwanted

solutes to urine ____________________

expel concentrated urine (N waste + solutes + toxins) from body

blood filtrate

concentratedurine

AP Biology

Mammalian Kidney

kidney

bladder

ureter

urethra

renal vein& artery

nephron

epithelialcells

adrenal glandinferior

vena cavaaorta

AP Biology

Nephron Functional units of kidney

1 million nephrons per kidney

Function filter out urea & other

solutes (salt, sugar…) ________________________

into nephron high pressure flow

________________________ of valuable solutes & H2O back into bloodstream greater flexibility & control

“counter current exchange system”

whyselective reabsorption

& not selectivefiltration?

AP Biology

Mammalian kidney

Proximaltubule

Distal tubule

Glomerulus

Collecting ductLoop of Henle

Aminoacids

Glucose

H2O

H2O

H2O

H2O

H2O

H2O

Na+ Cl-

Mg++ Ca++

Interaction of circulatory & excretory systems

Circulatory system _______________ =

ball of capillaries Excretory system

__________________ __________________ __________________

proximal tubule descending limb ascending limb distal tubule

__________________

How candifferent sectionsallow the diffusion

of different molecules?

Bowman’s capsule

Na+ Cl-

AP Biology

Nephron: Filtration At glomerulus

filtered out of blood H2O

glucose salts / ions urea

not filtered out cells proteins

high blood pressure in kidneys force to push (filter) H2O & solutes out of blood vessel

high blood pressure in kidneys force to push (filter) H2O & solutes out of blood vessel

BIG problems when you start out with high blood pressure in systemhypertension = kidney damage

BIG problems when you start out with high blood pressure in systemhypertension = kidney damage

AP Biology

Nephron: Re-absorption

Descendinglimb

Ascendinglimb

Proximal tubule reabsorbed back into blood

NaCl active transport

of Na+

Cl– follows by diffusion

H2O

glucose HCO3

-

bicarbonate buffer for

blood pH

AP Biology

Descendinglimb

Ascendinglimb

Nephron: Re-absorption Loop of Henle

________________ _________________

_________________ __________________

__________________

low permeability to salt few Na+ or Cl–

channels

reabsorbed H2O

structure fitsfunction!

AP Biology

Nephron: Re-absorption

Descendinglimb

Ascendinglimb

Loop of Henle ________________

low permeability to H2O

_________________ _________________

_________________ different membrane

proteins

reabsorbed salts

maintains osmotic gradient

structure fitsfunction!

AP Biology

Nephron: Re-absorption Distal tubule

reabsorbed salts H2O

HCO3-

bicarbonate

AP Biology

Nephron: Reabsorption & Excretion Collecting duct

reabsorbed H2O

excretion concentrated

urine passed to bladder impermeable

lining

Descendinglimb

Ascendinglimb

AP Biology

Osmotic control in nephron How is all this re-absorption achieved?

tight osmotic control to reduce the energy cost of excretion

use diffusion instead of active transportwherever possible

the value of acounter current exchange system

AP Biology

Summary _____________________

cells proteins remain in blood (too big)

Reabsorbed: __________________ Na+ amino acids Cl– glucose

Reabsorbed: __________________ Na+ Cl–

H2O Excreted

urea excess H2O excess solutes (glucose,

salts) toxins, drugs, “unknowns”

whyselective reabsorption

& not selectivefiltration?


Any Questions?



Maintaining Homeostasis

AP Biology

sensor

Negative Feedback Loop

high

low

hormone or nerve signal

lowersbody condition(return to set point)

hormone or nerve signal

gland or nervous system

raisesbody condition (return to set point)

gland or nervous system

sensor

specific body condition

AP Biology

Controlling Body Temperature

high

low

nerve signals

sweat

nerve signals

body temperature

shiver brain

dilates surfaceblood vessels

constricts surfaceblood vessels

Nervous System Control

brain

AP Biology

nephron

low

Blood Osmolarity

blood osmolarityblood pressure

ADH

increasedwater

reabsorption

increasethirst

high

Endocrine System Control

pituitary

ADH = AntiDiuretic Hormone

AP Biology

H2O

H2O

H2O

Maintaining Water BalanceGet morewater intoblood fast

Alcohol suppresses ADH…

makes youurinate a lot!

High blood osmolarity level too many solutes in blood

dehydration, high salt diet stimulates thirst = drink more release ADH from pituitary gland

antidiuretic hormone increases permeability of collecting duct

& reabsorption of water in kidneys increase water absorption back into blood decrease urination

AP Biology

low

Blood Osmolarity


increasedwater & saltreabsorption

in kidney

high


angiotensigenangiotensin

nephronadrenalgland

aldosterone

JGA

JGA = JuxtaGlomerular Apparatus

Oooooh,zymogen!

renin

AP Biology

Maintaining Water Balance Low blood osmolarity level

or low blood pressure JGA releases renin in kidney renin converts angiotensinogen to angiotensin angiotensin causes arterioles to constrict

increase blood pressure angiotensin triggers release of aldosterone from

adrenal gland increases reabsorption of NaCl & H2O in kidneys

puts more water & salts back in blood

Get morewater & salt into

blood fast!

adrenalgland

Why such arapid response

system?Spring a leak?

AP Biology

nephron

low

Blood Osmolarity


ADH

increasedwater

reabsorption

increasethirst

renin

increasedwater & saltreabsorption

high


pituitary

angiotensinogenangiotensin

nephronadrenalgland

aldosterone

JuxtaGlomerularApparatus


Don’t get batty…

Ask Questions!!

AP Biology 2008-2009 Regulating the Internal Environment.

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