An informa business SLA Pipeline Town Hall Meeting Christine Blazynski PhD Sr. Vice-President Product Development.

An informa business www.citeline.com

SLA Pipeline Town Hall Meeting

Christine Blazynski PhDSr. Vice-President

Product Development

An informa business www.citeline.com

TrialTroveClinical Trials Intelligence

Integrated and Enterprise-Wide ServicesPipeline / Pharmaprojects

Drug Intelligence

All Drugs InDevelopmentFrom BenchTo Market

TrialPredictTrials Timing / Benchmarking

Citeline Proprietary

Prediction of Trials Enrollment

Timing

World’s foremost collection

of

clinical trials,investigators, sites,

drugs & analysis

Global Coverage

Of Clinical Trials Design and Status

SiteTroveInvestigator / Site Selection

Investigators And Sites

Based UponDirect TrialsExperience

Citeline AnalyticsMapping the Competition

Map Date:

6/23/07 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4

Adjuvant

Phase II Biomarker/Tox

Phase III Biomarker/SE, PGX

EI, Biomarker/SE, PGX

Neoadjuvant

Phase II Biomarker/SE

PGX

Biomarker/SE

Biomarker/SE

Biomarker/SE

PGX

Biomarker/SE

Biomarker/SE

Phase III Biomarker/SE, PGX

PGX

NeoAdjuvant and Adjuvant

Phase II Biomarker/Tox

2010 2011

Competitive Development Map

20142012 201320052004

Drug: Tykerb (Lapatinib)Disease: Breast CancerAdjuvant and Neoadjuvant Therapy

2006 2007 2008 2009

Lap +Tras (+ AC,Doxo,Pac,Surg), 0/I/II/III, TA100, #70768

Lap, I/II/III, TA150, #52438

Lap, I/II/III, TA120, #45628

Lap (+ AC,Doc,Doxo), II/III, TA71, #60281

Lap (+/vs Tras, + Chemo), II/III, TA120, #63895

Lap (+/vs Tras, + Pac), I/II, TA450, NEO-ALTTO, (#53035)

Lap (+/vs Tras, +AC,Doxo), II/III, TA522, #71240

Lap (+/vs Let), II/III, TA91, #63171

Lap, II/III, #51923

Lap, II/III/IV, TA22-55, #33321

Lap (+ AC,Doxo,Pac,Tras), 0/I/II/III, TA109, #65110

Lap (4-arm trial), I/II, TA8000, ALTTO, (#45399)

Lap, I/II/III, TA3000, TEACH, (#56312)

Lap (+/vs Tras, + AC,Doxo), I/II, #55823

Lap (+ Pac,Surg), III/IV, AA50/TA60, #29064

Lap (+ Ab), I/II/III, TA30, #50405

Visualization ofClinical

DevelopmentPrograms

An informa business www.citeline.com

Depth and Breadth of Citeline Data

150 countries covered 180+ disease areas in TrialTrove/ >1000 in Pipeline

☐ 222 therapeutic categories in Pipeline 250+ analysts and editors 18,000 data sources >4,000 companies developing therapeutics >46,000 drugs

☐ Over 30 years of history >120,000 interventional trials >250,000 investigator profiles

An informa business www.citeline.com

Citeline’s Drug Intelligence

One centralized database of drug information

Deep integration with Citeline’s clinical development offerings

An informa business www.citeline.com

Pharmaprojects

Legacy pipeline database☐ PJB publications

Thirty-one continual years of tracking drug development☐ Print 3rd party electronic distributer CD ROM Web

delivery☐ Updated once weekly

Trends data from 1995 through 2010

An informa business www.citeline.com

Pipeline

Continually updated/real-time

Clean, simple, user-friendly interface

Customized alerts, saved searches, and share search

Unlimited research support

Search criteria expanded over time

All fields export or disease-focused export

Integration with TrialTrove, SiteTrove and TrialPredict

An informa business www.citeline.com

Export Options

An informa business www.citeline.com

An informa business www.citeline.com

Recent Enhancements

☐ Hierarchical mechanism search

☐ Addition of biosimilars/biogenerics

☐ Company country HQ search and research focus

☐ Delivery route/medium/technology search

☐ Advanced search [phase 1]

☐ Automatic search for trials from multiple drug results

☐ Search by latest change date or range

An informa business www.citeline.com

Pipeline

An informa business www.citeline.com

Planned Enhancements

☐ Advanced Search: nested booleans, ability to move search terms, edit operators within and between categories

☐ NCE search

☐ Search by chemical name

☐ Search by originator OR licensee

☐ Trial reporting: tabular view

☐ Dashboard reporting

An informa business www.citeline.com

An informa business www.citeline.com

Citeline’s Drug Intelligence

One centralized database of drug information

Drug, company data to meet all business development needs

An informa business www.citeline.com

Citeline - MedTrack MedTrack joined Citeline in late March 2011. As of April 6:

☐ 21,326 companies☐ 107,199 drugs (not all unique; includes generics)☐ 1,556 drug delivery technologies☐ 55,758 deals☐ 642 indications☐ 615,114 searchable news releases☐ 142,525 management bios☐ 481,558 searchable SEC documents

MedTrack V2 migration continues Planning for initial integration between products just starting but clear

synergies exist Need for market research and focus groups……… will you help?