AHF Timeline Infographic

HISTORY of ACUTE HEART FAILURE

1. Ventura. J Card Fail 2005;11:247–52; 2. Katz. Circulation 2008;1:63–71; 3. Ventura. Congestive Heart Failure 2001;7:172; 4. Davis et al. BMJ 2000;320:39–40; 5. http://fdazilla.com/drugs (Accessed 1 May 2013); 6. McMurray et al. Eur Heart J 2012;33:1787–847; 7. Ramirez & Abelmann. N Engl J Med 1974;290:499–501

4000BC

2000BC

There have been few advances in the treatment of acute heart failure (AHF). Many of the therapies used today

are the same as those introduced in the 1970’s

2000BC

475AD

1500

1900

1900

1970

1970

1990

1990

Present

Click on the timeline for information

HISTORY of ACUTE HEART FAILURE

1. Ventura. J Card Fail 2005;11:247–52; 2. Katz. Circulation 2008;1:63–71; 3. Ventura. Congestive Heart Failure 2001;7:172; 4. Davis et al. BMJ 2000;320:39–40; 5. http://fdazilla.com/drugs (Accessed 1 May 2013); 6. McMurray et al. Eur Heart J 2012;33:1787–847; 7. Ramirez & Abelmann. N Engl J Med 1974;290:499–501

4000BC

2000BC

There have been few advances in the treatment of acute heart failure (AHF). Many of the therapies used today

are the same as those introduced in the 1970’s

2000BC

475AD

1500

1900

1900

1970

1970

1990

1990

Present

Click on the timeline for information

The use of diuretic therapy for reducing excessfluid in cases of heart failure, dates back toAncient Egypt when a mixture of wormwood,

elderberries and beer was drunk.

4000BC

2000BC

HISTORY of ACUTE HEART FAILURE

1. Ventura. J Card Fail 2005;11:247–52; 2. Katz. Circulation 2008;1:63–71; 3. Ventura. Congestive Heart Failure 2001;7:172; 4. Davis et al. BMJ 2000;320:39–40; 5. http://fdazilla.com/drugs (Accessed 1 May 2013); 6. McMurray et al. Eur Heart J 2012;33:1787–847; 7. Ramirez & Abelmann. N Engl J Med 1974;290:499–501

4000BC

2000BC

There have been few advances in the treatment of acute heart failure (AHF). Many of the therapies used today

are the same as those introduced in the 1970’s

2000BC

475AD

1500

1900

1900

1970

1970

1990

1990

Present

Click on the timeline for information

Ancient Greek physicians characterized the symptoms of heart failure including breathlessness and fluid build-up

in the abdomen and around the body.

2000BC

475AD

HISTORY of ACUTE HEART FAILURE

1. Ventura. J Card Fail 2005;11:247–52; 2. Katz. Circulation 2008;1:63–71; 3. Ventura. Congestive Heart Failure 2001;7:172; 4. Davis et al. BMJ 2000;320:39–40; 5. http://fdazilla.com/drugs (Accessed 1 May 2013); 6. McMurray et al. Eur Heart J 2012;33:1787–847; 7. Ramirez & Abelmann. N Engl J Med 1974;290:499–501

4000BC

2000BC

There have been few advances in the treatment of acute heart failure (AHF). Many of the therapies used today

are the same as those introduced in the 1970’s

2000BC

475AD

1500

1900

1900

1970

1970

1990

1990

Present

Click on the timeline for information

William Withering’s book in 1785 cited extracts of digitalis, a type of plant, for treating excess fluid build up in the body.

Digitalis is the active ingredient in treatments used today such as Digoxin and Digitoxin.

1500

1900

HISTORY of ACUTE HEART FAILURE

1. Ventura. J Card Fail 2005;11:247–52; 2. Katz. Circulation 2008;1:63–71; 3. Ventura. Congestive Heart Failure 2001;7:172; 4. Davis et al. BMJ 2000;320:39–40; 5. http://fdazilla.com/drugs (Accessed 1 May 2013); 6. McMurray et al. Eur Heart J 2012;33:1787–847; 7. Ramirez & Abelmann. N Engl J Med 1974;290:499–501

4000BC

2000BC

There have been few advances in the treatment of acute heart failure (AHF). Many of the therapies used today

are the same as those introduced in the 1970’s

2000BC

475AD

1500

1900

1900

1970

1970

1990

1990

Present

Click on the timeline for information

1900

1970

The first half of the 20th Century saw the widespread use of diuretics. By 1967, loop diuretics, which block channels in the kidney and vasodilators, which relax blood vessels, were introduced as treatments for the symptoms of heart failure.

Both of which are still used today.

HISTORY of ACUTE HEART FAILURE

1. Ventura. J Card Fail 2005;11:247–52; 2. Katz. Circulation 2008;1:63–71; 3. Ventura. Congestive Heart Failure 2001;7:172; 4. Davis et al. BMJ 2000;320:39–40; 5. http://fdazilla.com/drugs (Accessed 1 May 2013); 6. McMurray et al. Eur Heart J 2012;33:1787–847; 7. Ramirez & Abelmann. N Engl J Med 1974;290:499–501

4000BC

2000BC

There have been few advances in the treatment of acute heart failure (AHF). Many of the therapies used today

are the same as those introduced in the 1970’s

2000BC

475AD

1500

1900

1900

1970

1970

1990

1990

Present

Click on the timeline for information

1970

1990

During the 1970’s and 1980’s, intravenous nitrates and inotropes were approved for patients with AHF. These drugs assist patients by relaxing blood vessels and increasing the

number of contractions in the heart, respectively. Nitrates are still used to treat acute heart failure today.

IV

HISTORY of ACUTE HEART FAILURE

1. Ventura. J Card Fail 2005;11:247–52; 2. Katz. Circulation 2008;1:63–71; 3. Ventura. Congestive Heart Failure 2001;7:172; 4. Davis et al. BMJ 2000;320:39–40; 5. http://fdazilla.com/drugs (Accessed 1 May 2013); 6. McMurray et al. Eur Heart J 2012;33:1787–847; 7. Ramirez & Abelmann. N Engl J Med 1974;290:499–501

4000BC

2000BC

There have been few advances in the treatment of acute heart failure (AHF). Many of the therapies used today

are the same as those introduced in the 1970’s

2000BC

475AD

1500

1900

1900

1970

1970

1990

1990

Present

Click on the timeline for information

Despite significant progress in treating patients with other heart conditions, patients with AHF haven’t benefited from a treatment breakthrough in 20 years. Commonly used medicines for AHF treat only the immediate signs and symptoms, such as fluid build up

and shortness of breath. There is an urgent need for new treatments that have the potential to increase a patient’s life expectancy and protect vital organs against the

life-threatening damage of an AHF episode.

1990

Present