Access in Access in Pediatric CRRT Pediatric CRRT Patrick D Brophy MD Patrick D Brophy MD Pediatric Nephrology, Dialysis & Pediatric Nephrology, Dialysis & Transplantation Transplantation CS Mott Children’s Hospital CS Mott Children’s Hospital University of Michigan University of Michigan
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Access in Pediatric CRRT Patrick D Brophy MD Pediatric Nephrology, Dialysis & Transplantation CS Mott Children’s Hospital University of Michigan.
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Access in Access in Pediatric CRRTPediatric CRRT
Patrick D Brophy MDPatrick D Brophy MDPediatric Nephrology, Dialysis & Pediatric Nephrology, Dialysis &
High Recirculation RateHigh Recirculation Rate KinkingKinking
Shorter and Larger CathetersShorter and Larger Catheters SIZE DOES MATTERSIZE DOES MATTER Lower Resistance Lower Resistance Improved BloodflowImproved Bloodflow
Minimum 30 to 50 ml/min to minimize Minimum 30 to 50 ml/min to minimize access and filter clottingaccess and filter clotting
Maximum rate of 400 ml/min/1.73mMaximum rate of 400 ml/min/1.73m2 2 oror 10-12 ml/kg/min in neonates and infants10-12 ml/kg/min in neonates and infants 4-6 ml/kg/min in children4-6 ml/kg/min in children 2-4 ml/kg/min in adolescents2-4 ml/kg/min in adolescents
PATIENT SIZE CATHETER SIZE &
SOURCE
SITE OF INSERTION
NEONATE Single-lumen 5 Fr (COOK) Femoral artery or vein
Dual-Lumen 7.0 French
(COOK/MEDCOMP)
Femoral vein
3-6 KG Dual-Lumen 7.0 French
(COOK/MEDCOMP)
Internal/External-Jugular,
Subclavian or Femoral vein
Triple-Lumen 7.0 Fr
(MEDCOMP)
Internal/External-Jugular,
Subclavian or Femoral vein
6-30 KG Dual-Lumen 8.0 French
(KENDALL, ARROW)
Internal/External-Jugular,
Subclavian or Femoral vein
>15-KG Dual-Lumen 9.0 French
(MEDCOMP)
Internal/External-Jugular,
Subclavian or Femoral vein
>30 KG Dual-Lumen 10.0 French
(ARROW, KENDALL)
Internal/External-Jugular,
Subclavian or Femoral vein
>30 KG Triple-Lumen 12.5 French
(ARROW, KENDALL)
Internal/External-Jugular,
Subclavian or Femoral vein
Venous Access for CRRTVenous Access for CRRT
Match catheter size to patient size Match catheter size to patient size and anatomical siteand anatomical site
One dual- or triple-lumen or two One dual- or triple-lumen or two single lumen uncuffed catheterssingle lumen uncuffed catheters
SitesSites femoralfemoral internal jugularinternal jugular avoid sub-clavian vein if possibleavoid sub-clavian vein if possible
Catheter PositionCatheter Position
No Right or Wrong Choice of No Right or Wrong Choice of PlacementPlacement FACTORSFACTORS
Clinical expertiseClinical expertise Body HabitusBody Habitus Other catheters (Citrate anticoag-triple Other catheters (Citrate anticoag-triple
Internal Jugular-Right- aim for RA to Internal Jugular-Right- aim for RA to secure adequate BFRsecure adequate BFR
Subclavian-Patient mobility? Most Subclavian-Patient mobility? Most frequent site of inadequate frequent site of inadequate performance -catheter curves and performance -catheter curves and abutts against SVC-Vein collapses abutts against SVC-Vein collapses against catheter due to against catheter due to positional/volume changepositional/volume change
Femoral- optimal position in tip of IVCFemoral- optimal position in tip of IVC
Vascular Access for Pediatric Vascular Access for Pediatric CRRT: Pros and Cons of CRRT: Pros and Cons of
Femoral SiteFemoral Site
Relatively larger vessel Relatively larger vessel may allow formay allow for larger catheterlarger catheter higher flowshigher flows
Ease of placementEase of placement No risk of No risk of
Femoral versus IJ catheter Femoral versus IJ catheter performanceperformance
TypeType NumberNumber Qb Qb (ml/min)(ml/min)
RecirculationRecirculation(%)(%) 95% CI95% CI
FemoralFemoral 2626 237.1237.1 13.1*13.1* 7.6 to 7.6 to 18.618.6
> > 20cm20cm
1919 233.3233.3 8.5**8.5** 2.9 to 2.9 to 13.713.7
< < 20cm20cm
77 247.5247.5 26.3**26.3** 17.1 to 17.1 to 35.535.5
JugularJugular 1313 226.4226.4 0.4*0.4* -0.1 to 1.0-0.1 to 1.0
Little et al: AJKD 36:1135-9, 2000
* p<0.001** p<0.007
Troubleshooting AccessTroubleshooting Access
How can you tell if How can you tell if you have a you have a problem before problem before starting?starting?
Check placement Check placement first, then use first, then use syringe to test syringe to test resistance and resistance and blood return.blood return.
What if you have What if you have problems during problems during treatment?treatment?
Check line for Check line for kink, then assess kink, then assess patients position or patients position or need for sedation.need for sedation.
AccessAccess Clotting or sluggish catheter.Clotting or sluggish catheter.
tPA (tissue plasminogen activator).tPA (tissue plasminogen activator). (Spry et al., Dialysis&Transplantation. Jan. 2001).(Spry et al., Dialysis&Transplantation. Jan. 2001).
Normal saline flush.Normal saline flush.
Reason to replace catheter.Reason to replace catheter. Clotted catheter with no response to tPA.Clotted catheter with no response to tPA. Exit site blood leakage with no response to Exit site blood leakage with no response to
pressure dressing.pressure dressing. Severe kinked catheter.Severe kinked catheter. Bad re-circulation issues.Bad re-circulation issues.
PressuresPressures Arterial or outflow pressuresArterial or outflow pressures
High negative pressure = access problem.High negative pressure = access problem. High positive pressure = filter problem.High positive pressure = filter problem. Moderate to high positive pressure + high return Moderate to high positive pressure + high return
Venous or return pressuresVenous or return pressures Moderate to high positive pressure + high arterial Moderate to high positive pressure + high arterial
Vascular Access for Pediatric Vascular Access for Pediatric CRRT:CRRT:
Some Final ThoughtsSome Final Thoughts
Catheters with poor function will function Catheters with poor function will function poorly… over and over and over and overpoorly… over and over and over and over
Balance between surgical/ICU expertise Balance between surgical/ICU expertise (preference?) and the necessary evils (preference?) and the necessary evils dictated by the patientdictated by the patient high PEEP… femoral catheter?high PEEP… femoral catheter? massive ascites… IJ catheter?massive ascites… IJ catheter? available sites… are there any?available sites… are there any?
Which vessel are you willing to traumatize?Which vessel are you willing to traumatize?
ConclusionsConclusions
Poor Access-- May as well stopPoor Access-- May as well stop Choice- patient size and optimal flowsChoice- patient size and optimal flows Site- IJ/Femoral -recommendedSite- IJ/Femoral -recommended Care- Local standard + Lock issues- Care- Local standard + Lock issues-
heparinheparin Troubleshooting- anticipate, what is Troubleshooting- anticipate, what is
the machine saying?the machine saying? Happy Hemofiltering!Happy Hemofiltering!
Thanks!Thanks!
Stu GoldsteinStu Goldstein Tim BunchmanTim Bunchman Theresa MottesTheresa Mottes Tim KudelkaTim Kudelka Betsy AdamsBetsy Adams Tammy KellyTammy Kelly Robin NievaardRobin Nievaard