December 12, 2017 1 Aaron Michael Mohs, Ph.D. Department of Pharmaceutical Sciences College of Pharmacy University of Nebraska Medical Center Physical Address: 5-12315 Scott Research Tower Fred & Pamela Buffett Cancer Center 986858 Nebraska Medical Center Omaha, NE 68198-6858 EDUCATION Aug. 2002 – Dec. 2006 Doctor of Philosophy Pharmaceutics and Pharmaceutical Chemistry University of Utah Salt Lake City, UT Dissertation: Biodegradable Macromolecular Contrast Agents for Magnetic Resonance Imaging. (Defended Sept. 28, 2006) Mentor: Dr. Zheng-Rong Lu, Ph.D. Aug. 1998 – May 2002 Bachelor of Arts Chemistry (Biology concentration) Saint John’s University/College of Saint Benedict Collegeville, MN Undergraduate Research: Bidentate nitrogenous molybdenum complexes as catalysts. Mentor: Dr. Chris Schaller, Ph.D. POSTDOCTORAL TRAINING Oct. 2006 – July 2011 Postdoctoral Fellowship Biomedical Engineering Emory University–Georgia Institute of Technology Atlanta, GA Research Emphasis: Nanotechnology for Biomedical Imaging Applications Mentor: Dr. Shuming Nie, Ph.D. ACADEMIC APPOINTMENTS 2015 – Present Assistant Professor (Tenure-Track), Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center
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Aaron Michael Mohs, Ph.D. 12, 2017 1 Aaron Michael Mohs, Ph.D. Department of Pharmaceutical Sciences College of Pharmacy University of Nebraska Medical Center
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2013–2014 Selection Committee Chair, Wake Forest Institute of RegenerativeMedicine Young Investigator Award; Tissue Engineering andRegenerativeMedicineInternationalSociety
2013–2014 Abstract Reviewer, Cancer Technologies, Biomedical EngineeringSocietyAnnualMeeting
2013 Invited Faculty Panelist on Career Development at the BiomaterialsGordonResearchSeminar;Holderness,NH
5. Kelkar SS, Hill TK, Payne WM,Mohs AM. Near Infrared Fluorescent Self-AssembledNanoparticles for Image-Guided Surgery; Materials Research Society Fall Meeting &Exhibit;Boston,MA,December2015.
7. Mohs AM, Raghavan S, Gilmont R, Somara S, Marini FC, Bitar KN. Near InfraredFluorescent Neural Progenitor Cells to Track Differentiation and Tissue Innervation;BiomedicalEngineeringSocietyAnnualMeeting;SanAntonio,TX,October2014.
8. MohsAM.NanotechnologyforMinimallyInvasiveCancerDetectionandResection;NCIAlliance for Nanotechnology in Cancer InvestigatorsMeeting; Rockville, MD, October2014.
9. Mohs AM. Near Infrared Fluorescent Protein Labeling of Enteric Nerve Cells:Development and Initial Characterization of IM-FEN-iRFP Cells, North Carolina TissueEngineering and RegenerativeMedicine Society AnnualMeeting;Winston-Salem, NC,October2013.
10. Mohs AM. Nanotechnology for Image-Guided Intervention: Potential for ProstateCancer?, Prostate Cancer Research and Translation Symposium; Winston-Salem, NC,March2013.
11. MohsAM,ManciniMC,QianX,WangY,ProvenzaleJM,NieS.NanotechnologyforGuidedTumor Resection, NCI Alliance for Nanotechnology in Cancer Investigators Meeting;Houston,TX,November2012.
12. Mohs AM, Wang Y, Qian X, Mancini MC, Provenzale J, Nie S. Nanotechnology forSpectroscopic and Image-Guided Tumor Resection, Biomedical Engineering SocietyAnnualMeeting;Atlanta,GA,October2012.
15. MohsAM,ManciniMC,ProvenzaleJM,SinghalS,WangMD,NieS.Ahand-heldimagingand spectroscopy device for intraoperative, contrast-enhanced tumor detection,BiomedicalEngineeringSocietyAnnualMeeting;Austin,TX,October2010.
16. MohsAM,RazaSH,White,WB,KaddiC,ManciniMC,NieS,WangMD,SinghalS.Thedevelopment of a novel endoscope to visualize residual tumor cells following cancersurgery,AmericanCollegeofSurgeons95thAnnualClinicalCongress;Chicago,IL,October2009.
17. Mohs AM, Smith AM, Mancini MC, Wen MM, Nie S. Investigating the Interactions,Consequences,andApplicationsofNanoparticlesatBiologicalInterfaces,NCIAllianceforNanotechnologyinCancerInvestigatorsMeeting;Chicago,IL,September2008.
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18. MohsAM,ZongY,GoodrichKC,ParkerDL,LuZR.PEG-g-(GdDTPA-co-L-cystine):effectofPEG chain lengthon in vivo contrast enhancement inMRI,UtahCenter forAdvancedImagingResearch17thAnnualSymposium;SaltLakeCity,UT,October2005.
1. Mohs AM. Surgical imaging using near infrared fluorescence. South Dakota StateUniversity;Brookings,SD,December2017.
2. Mohs AM. Biomedical imaging and nanotechnology: An example of how clinicalchallenges guide scientific innovation. Glen Arth Seminar Series, College of St.Benedict/St.John’sUniversity;St.Joseph,MN,November2016.
3. Mohs AM. Contrast-enhanced fluorescence for intraoperative imaging. Frank ReidyResearchCenterforBioelectrics(FRRCBE),OldDominionUniversity;Norfolk,VA,October2016.
4. MohsAM.Hyaluronan-derivednanoparticlesforbiomedicalapplications:Experiencesinimaging and drug delivery. China Pharmaceutical University; Nanjing, China, October2016.
5. MohsAM. The Role of CancerNanotechnology for Intraoperative Imaging, College ofEngineering,UniversityofNebraskaatLincoln;Lincoln,NE,April2016.
8. MohsAM.Nanotechnology for Image-GuidedTumorSurgery;BiomedicalEngineering,UniversityofSouthDakota;SiouxFalls,SD,September2014.
9. MohsAM.HyaluronicAcidDerivedNanoparticles for Image-GuidedSurgery andDrugDelivery;Chemistry,WakeForestUniversity;Winston-Salem,NC,September2014.
10. Mohs AM. Nanotechnology for Emerging Biomedical Applications, Joint School forNanoscience andNanoengineering atUNCGreensboro andNCA&T,Greensboro,NC,November2012.
11. MohsAM.Nanotechnologyformedicalandsurgicalimaging:currentstatusandfuturepossibilities, Duke Radiology Grand Rounds; Durham, NC, January 2011 (co-presenterProvenzaleJM).
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12. Mohs AM.Wide-field optical imagingwith interactive excitation and spectroscopy toresectcontrast-enhancedtumors,NortheasternUniversity;Boston,MA,January2011.
PUBLICATIONSA) PublishedJournalArticles(oldesttonewest)1. MohsAM,WangX,GoodrichKC, ZongY, ParkerDL, Lu Z-R. PEG-g-poly(GdDTPA-co-L-
cystine): a biodegradablemacromolecular blood pool contrast agent forMR imaging.BioconjugChem.2004;15(6):1424–30.PMID:15546211
2. MohsAM,ZongY,GuoJ,ParkerDL,LuZ-R.PEG-g-poly(GdDTPA-co-L-cystine):effectofPEG chain length on in vivo contrast enhancement in MRI. Biomacromolecules.2005;6(4):2305–11.PMID:16004476
3. ZongY,WangX,GoodrichKC,MohsAM,ParkerDL,LuZ-R.Contrast-enhancedMRIwithnew biodegradable macromolecular Gd(III) complexes in tumor-bearing mice.MagnResonMed.2005;53(4):835–42.PMID:15799038
4. Lu Z-R, Mohs AM, Zong Y, Feng Y. Polydisulfide Gd(III) chelates as biodegradablemacromolecular magnetic resonance imaging contrast agents. Int J Nanomedicine.2006;1(1):31–40.PMID:17722260
5. Zong Y, Guo J, Ke T, Mohs AM, Parker DL, Lu Z-R. Effect of size and charge onpharmacokineticsandinvivoMRIcontrastenhancementofbiodegradablepolydisulfideGd(III)complexes.JControlRelease.2006;112(3):350–6.PMID:16631270
6. MohsAM,NguyenT,JeongE-K,FengY,EmersonL,ZongY,ParkerDL,LuZ-R.ModificationofGd-DTPA cystine copolymerswithPEG-1000optimizespharmacokinetics and tissueretention for magnetic resonance angiography.Magn Reson Med. 2007;58(1):110–8.PMID:17659618
7. Mohs AM, Lu Z-R. Gadolinium(III)-based blood-pool contrast agents for magneticresonanceimaging:statusandclinicalpotential.ExpertOpinDrugDeliv.2007;4(2):149–64.PMID:17335412
8. FengY,JeongE-K,MohsAM,EmersonL,LuZ-R.Characterizationoftumorangiogenesiswith dynamic contrast-enhanced MRI and biodegradable macromolecular contrastagentsinmice.MagnResonMed.2008;60(6):1347–52.PMID:19025902
10. Smith AM,Mohs AM, Nie S. Tuning the optical and electronic properties of colloidalnanocrystalsbylatticestrain.NatNanotechnol.2009;4(1):56–63.PMID:19119284
12. MohsAM, Provenzale JM. Applications of nanotechnology to imaging and therapy ofbraintumors.NeuroimagingClinNAm.2010;20(3):283–92.PMID:20708547
13. MohsAM,ManciniMC,SinghalS,ProvenzaleJM,Leyland-JonesB,WangMD,NieS.Hand-held spectroscopic device for in vivo and intraoperative tumor detection: contrastenhancement, detection sensitivity, and tissue penetration. Anal Chem.2010;82(21):9058–65.PMID:20925393
14. Provenzale JM, Mohs AM. Nanotechnology in neurology-current status and futurepossibilities.USNeurol.2010;6(1):12–17.
17. MohsAM*,ManciniMC,Provenzale JM, SabaCF,Cornell KK,HowerthEW,Nie S.Anintegrated widefield imaging and spectroscopy system for contrast-enhanced, image-guided resection of tumors. IEEE Trans Biomed Eng. 2015;62(5):1416–1424. PMID:25585410.*Denotescorrespondingauthor.
18. HillTK,AbdulahadA,KelkarSS,MariniFC,LongTE,ProvenzaleJM,MohsAM.Indocyaninegreen-loaded nanoparticles for image-guided tumor surgery. Bioconjug Chem.2015;26(2):294–303.PMID:25565445
19. Stevenson AT, Reese LM, Hill TK, McGuire J, Mohs AM, Shekhar R, Bickford LR,Whittington AR. Fabrication and characterization of medical grade polyurethanecomposite catheters for near-infrared imaging. Biomaterials. 2015;54:168–76. PMID:25907050
21. Hill TK,Mohs AM. Image-guided tumor surgery: will there be a role for fluorescentnanoparticles?WIREsNanomedNanobiotechnol.2016;8(4):498–511.PMID:26585556
27. SouchekJJ,DavisAL,HillTK,HolmesMB,QiB,SinghPK,KridelSJ,MohsAM.Combinationtreatmentwithorlistat-containingnanoparticlesandtaxanesissynergisticandenhancesmicrotubule stability in taxane-resistant prostate cancer cells.Mol Cancer Ther.2017;16(9):1819-1830.PMID:28615298
28. PayneWM,HillTK,SvechkarevD,HolmesMB,SajjaB,MohsAM.Multimodal imagingnanoparticles derived from hyaluronic acid for integrated preoperative andintraoperativecancer imaging.ContrastMediaMol Imaging.2017;Article ID9616791.PMID:29097944
5. BhattacharyaDS,SvechkarevD,Souchek JJ,Hill TK,TaylorM,NatarajanA,MohsAM.TuninghyaluronicacidbindingpropertiestoCD44usingsynthetic, invitroandinsilicoapproaches. 253rd American Chemical Society National Meeting and Exposition; SanFrancisco,CA,April2017.Poster.
6. HillTK,KelkarSS,SouchekJJ,PayneWM,MariniFC,MohsAM.Nearinfraredhyaluronan-derived nanoparticles for fluorescence image-guided tumor surgery. Imaging in 2020;JacksonHole,WY,September2016.Poster.
7. SouchekJJ,HillTK,DavisAL,QiB,HolmesMB,SinghPK,KridelSJ,MohsAM.Combinationtreatment with Nano-Orlistat and taxanes is synergistic and enhances microtubulestability in taxane-resistant prostate cancer cells. 14th International Nanomedicine &DrugDeliverySymposium(NanoDDS);Baltimore,MD,September2016.Poster.*Selectedfor “Rapid Fire Presentation” and awarded Society for Biomaterials-Drug DeliverySpecialInterestGroupResearchAward
8. Payne WM, Svechkarev DA, Boska MD, Mohs AM. Multimodal contrast agents forintegrated preoperative and intraoperative cancer imaging. AACR Engineering andPhysicalSciencesinOncology;Boston,MA,June2016.Poster.