A Process Model of Rho GTP-binding Proteins Luca Cardelli 1, 4 Emmanuelle Caron 2, 4 Philippa Gardner 3, 4 Ozan Kahramanoğulları 3, 4 Andrew Phillips 1 1. Microsoft Research Cambridge 2. Centre for Molecular Biology and Infection, Imperial College 3. Department of Computing, Imperial College 4. CISBIC, Imperial College 20.11.2007 – CISB’07, Newcastle
A Process Model of Rho GTP-binding Proteins. Luca Cardelli 1, 4 Emmanuelle Caron 2, 4 Philippa Gardner 3, 4 Ozan Kahramanoğulları 3, 4 Andrew Phillips 1 1. Microsoft Research Cambridge 2. Centre for Molecular Biology and Infection, Imperial College - PowerPoint PPT Presentation
Welcome message from author
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
and with varying r3 and r4, there is no effect on the inhibitory behavior of the GDIs.
r1=1, r2=104
r1=10-4, r2=104 r1=10-4, r2=10-4
Outlook
• A process model of Rho GTP-binding proteins.• Our model successfully mimics the ODE model.• We compositionally extend the model with GDIs. • Parameter estimation by hand (and automated?).• Rho GTP-binding proteins: experimental validation
of GDI and active Rho binding.• By composing this model with other components of
FcR-mediated phagocytosis, e.g., actin polymerisation, obtain a systems understanding.
• Reuse the Rho-GTP model as a template for Ras super-family proteins.