dt=+ k1(rdquoHalpha hydroxylationrdquo) middot [rdquoHalphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo]
)minus(k1(rdquoH2alpha bindingrdquo) middot [H2alpha] middot [rdquoPD2minus Fe2minusDGminusO2minus ASrdquo]
minus k2(rdquoH2alpha bindingrdquo) middot [rdquoH2alphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo])
minus(k1(rdquoH2alpha binding without ASrdquo) middot [rdquoPD2minus Fe2minusDGminusO2rdquo] middot [H2alpha]
minus k2(rdquoH2alpha binding without ASrdquo) middot [rdquoH2alphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo])
+(k1(rdquoH2alpha bindingrdquo) middot [H2alpha] middot [rdquoPD2minus Fe2minusDGminusO2minus ASrdquo]
minus k2(rdquoH2alpha bindingrdquo) middot [rdquoH2alphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo])
+(k1(rdquoH2alpha binding without ASrdquo) middot [rdquoPD2minus Fe2minusDGminusO2rdquo] middot [H2alpha]
minus k2(rdquoH2alpha binding without ASrdquo) middot [rdquoH2alphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo])
minus k1(rdquoH2alpha hydroxylationrdquo) middot [rdquoH2alphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo]
dt=+ k1(rdquoH2alpha hydroxylationrdquo) middot [rdquoH2alphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo]
APPENDIX A LIST OF EQUATIONS
d ([rdquoTf minus Fe_intercellrdquo] )dt
=
+
(a(rdquoFpn Exportrdquo) middot
[Fpn]n(rdquoFpn Exportrdquo)
Kn(rdquoFpn Exportrdquo)
(rdquoFpn Exportrdquo) + [Fpn]n(rdquoFpn Exportrdquo)middot [LIP]
)minus k1(rdquoTfR1 bindingrdquo) middot [rdquoTf minus Fe_intercellrdquo] middot [TfR]
+ k1(rdquoTfR1 releaserdquo) middot [rdquoTf minus Feminus TfR1rdquo]
minus k1(rdquoTfR2 bindingrdquo) middot [rdquoTf minus Fe_intercellrdquo] middot [TfR2]
+ k1(rdquoTfR2 releaserdquo) middot [rdquoTf minus Feminus TfR2rdquo]
minus k1(rdquoTfR1 binding 2rdquo) middot [rdquoTf minus Feminus TfR1rdquo] middot [rdquoTf minus Fe_intercellrdquo]
+ k1(rdquoTfR1 release 2rdquo) middot [rdquo2(Tf minus Fe)minus TfR1rdquo]
minus k1(rdquoTfR2 binding 2rdquo) middot [rdquoTf minus Feminus TfR2rdquo] middot [rdquoTf minus Fe_intercellrdquo]
+ k1(rdquoTfR2 release 2rdquo) middot [rdquo2(Tf minus Fe)minus TfR2rdquo]
+
(a(rdquoint Fpn Exportrdquo) middot
[intFpn]n(rdquoint Fpn Exportrdquo)
Kn(rdquoint Fpn Exportrdquo)
(rdquoint Fpn Exportrdquo) + [intFpn]n(rdquoint Fpn Exportrdquo)middot [intLIP]
)
(A025)
d ([TfR] )
dt=
+a2(rdquoTfR1 expressionrdquo) middot [Halpha]n(rdquoTfR1 expressionrdquo)
K2n(rdquoTfR1 expressionrdquo)
(rdquoTfR1 expressionrdquo) + [Halpha]n(rdquoTfR1 expressionrdquo)
+a(rdquoTfR1 expressionrdquo) middot [IRP]n(rdquoTfR1 expressionrdquo)
Kn(rdquoTfR1 expressionrdquo)
(rdquoTfR1 expressionrdquo) + [IRP]n(rdquoTfR1 expressionrdquo)
minus k1(rdquoHFE TfR1 bindingrdquo) middot [HFE] middot [TfR]
+ k1(rdquoHFE TfR1 releaserdquo) middot [rdquoHFEminus TfRrdquo]
minus k1(rdquoTfR1 bindingrdquo) middot [rdquoTf minus Fe_intercellrdquo] middot [TfR]
+ k1(rdquoTfR1 releaserdquo) middot [rdquoTf minus Feminus TfR1rdquo]
minus k1(rdquoTfR1 degradationrdquo) middot [TfR]
+(k1(rdquoTfR1 iron internalisationrdquo) middot [rdquo2(Tf minus Fe)minus TfR1rdquo]
)(A026)
184
d ([rdquoTf minus Feminus TfR1rdquo] )
dt= +Vintercell middot
(k1(rdquoTfR1 bindingrdquo) middot [rdquoTf minus Fe_intercellrdquo] middot [TfR]
)minus k1(rdquoTfR1 releaserdquo) middot [rdquoTf minus Feminus TfR1rdquo]
minus k1(rdquoTfR1 binding 2rdquo) middot [rdquoTf minus Feminus TfR1rdquo] middot [rdquoTf minus Fe_intercellrdquo]
+ k1(rdquoTfR1 release 2rdquo) middot [rdquo2(Tf minus Fe)minus TfR1rdquo]
(A027)
d ([HFE] )
dt=minus k1(rdquoHFE TfR1 bindingrdquo) middot [HFE] middot [TfR]
+ k1(rdquoHFE TfR1 releaserdquo) middot [rdquoHFEminus TfRrdquo]
minus 2 middot k1(rdquoHFE TfR2 bindingrdquo) middot [HFE] middot [HFE] middot [TfR2]
+ 2 middot k1(rdquoHFE TfR2 releaserdquo) middot [rdquo2HFEminus TfR2rdquo]
minus k1(rdquoHFE TfR1 binding 2rdquo) middot [rdquoHFEminus TfRrdquo] middot [HFE]
+ k1(rdquoHFE TfR1 release 2rdquo) middot [rdquo2HFEminus TfRrdquo]
minus k1(rdquoHFE degradationrdquo) middot [HFE]
+ v(rdquoHFE expressionrdquo)
(A028)
d ([rdquoHFEminus TfRrdquo] )
dt=+ k1(rdquoHFE TfR1 bindingrdquo) middot [HFE] middot [TfR]
minus k1(rdquoHFE TfR1 releaserdquo) middot [rdquoHFEminus TfRrdquo]
minus k1(rdquoHFE TfR1 binding 2rdquo) middot [rdquoHFEminus TfRrdquo] middot [HFE]
+ k1(rdquoHFE TfR1 release 2rdquo) middot [rdquo2HFEminus TfRrdquo]
(A029)
d ([rdquoTf minus Feminus TfR2rdquo] )
dt=+ k1(rdquoTfR2 bindingrdquo) middot [rdquoTf minus Fe_intercellrdquo] middot [TfR2]
minusk1(rdquoTfR2 releaserdquo) middot [rdquoTf minus Feminus TfR2rdquo]
minusk1(rdquoTfR2 binding 2rdquo) middot [rdquoTf minus Feminus TfR2rdquo] middot [rdquoTf minus Fe_intercellrdquo]
+k1(rdquoTfR2 release 2rdquo) middot [rdquo2(Tf minus Fe)minus TfR2rdquo]
(A030)
185
APPENDIX A LIST OF EQUATIONS
d ([rdquo2(Tf minus Fe)minus TfR1rdquo] )
dt=+ k1(rdquoTfR1 binding 2rdquo) middot [rdquoTf minus Feminus TfR1rdquo] middot [rdquoTf minus Fe_intercellrdquo]
minus k1(rdquoTfR1 release 2rdquo) middot [rdquo2(Tf minus Fe)minus TfR1rdquo]
minus k1(rdquoTfR1 iron internalisationrdquo) middot [rdquo2(Tf minus Fe)minus TfR1rdquo]
(A031)
d ([rdquo2HFEminus TfRrdquo] )
dt= + k1(rdquoHFE TfR1 binding 2rdquo) middot [rdquoHFEminus TfRrdquo] middot [HFE]
minus k1(rdquoHFE TfR1 release 2rdquo) middot [rdquo2HFEminus TfRrdquo]
minus k1(rdquoHFETfR degradationrdquo) middot [rdquo2HFEminus TfRrdquo]
(A032)
d ([rdquo2HFEminus TfR2rdquo])
dt= + k1(rdquoHFE TfR2 bindingrdquo) middot [HFE] middot [HFE] middot [TfR2]
minus k1(rdquoHFE TfR2 releaserdquo) middot [rdquo2HFEminus TfR2rdquo]
xs minus k1(rdquoHFETfR2 degradationrdquo) middot [rdquo2HFEminus TfR2rdquo]
(A033)
d ([rdquo2HFEminus TfR2rdquo] )
dt=+ k1(rdquoHFE TfR2 bindingrdquo) middot [HFE] middot [HFE] middot [TfR2]
minus k1(rdquoHFE TfR2 releaserdquo) middot [rdquo2HFEminus TfR2rdquo]
minus k1(rdquoHFETfR2 degradationrdquo) middot [rdquo2HFEminus TfR2rdquo]
(A034)
d ([rdquo2HFEminus TfR2rdquo])
dt=+ k1(rdquoHFE TfR2 bindingrdquo) middot [HFE] middot [HFE] middot [TfR2]
minus k1(rdquoHFE TfR2 releaserdquo) middot [rdquo2HFEminus TfR2rdquo]
minus k1(rdquoHFETfR2 degradationrdquo) middot [rdquo2HFEminus TfR2rdquo]
(A035)
186
d ([rdquo2(Tf minus Fe)minus TfR2rdquo] )
dt=
+ k1(rdquoTfR2 binding 2rdquo) middot [rdquoTf minus Feminus TfR2rdquo] middot [rdquoTf minus Fe_intercellrdquo]
minus k1(rdquoTfR2 release 2rdquo) middot [rdquo2(Tf minus Fe)minus TfR2rdquo]
minus k1(rdquoTfR2 iron internalisationrdquo) middot [rdquo2(Tf minus Fe)minus TfR2rdquo]
(A036)
d ([TfR2] )
dt=minus a(rdquoTfR2 degradationrdquo) middot [TfR2]
middot
(1 minus [rdquoTf minus Fe_intercellrdquo]n(rdquoTfR2 degradationrdquo)
Kn(rdquoTfR2 degradationrdquo)
(rdquoTfR2 degradationrdquo) + [rdquoTf minus Fe_intercellrdquo]n(rdquoTfR2 degradationrdquo)
)minus k1(rdquoHFE TfR2 bindingrdquo) middot [HFE] middot [HFE] middot [TfR2]
+ k1(rdquoHFE TfR2 releaserdquo) middot [rdquo2HFEminus TfR2rdquo]
minus k1(rdquoTfR2 bindingrdquo) middot [rdquoTf minus Fe_intercellrdquo] middot [TfR2]
+ k1(rdquoTfR2 releaserdquo) middot [rdquoTf minus Feminus TfR2rdquo]
+(k1(rdquoTfR2 iron internalisationrdquo) middot [rdquo2(Tf minus Fe)minus TfR2rdquo]
)+ v(rdquoTfR2 expressionrdquo)
(A037)
d ([Heme_intercell] )dt
=minusV(rdquoHeme uptakerdquo) middot [Heme_intercell]
Km(rdquoHeme uptakerdquo) + [Heme_intercell]
+
(V(rdquoHeme exportrdquo) middot [Heme]
Km(rdquoHeme exportrdquo) + [Heme]
)+
(V(rdquoint Heme Exportrdquo) middot [intHeme]
Km(rdquoint Heme Exportrdquo) + [intHeme]
)
(A038)
187
APPENDIX A LIST OF EQUATIONS
d ([intLIP] )
dt=+K(rdquoint Ferritin Degredation Full Iron Releaserdquo) middot
[intFT1]
[intFT]middot [intFT]
+ [intFT1] middot kloss(rdquoint Ferritin internalised iron releaserdquo)
middot
(1 +
0048 middot [intFT1][intFT]
1 + [intFT1][intFT]
)minus k1(rdquoint Ferritin Iron bindingrdquo) middot [intLIP] middot [intFT]
+ k1(rdquoint Ferritin Iron releaserdquo) middot [rdquointFeminus FTrdquo]
minus 2 middot
(a(rdquoint Fpn Exportrdquo) middot
[intFpn]n(rdquoint Fpn Exportrdquo)
Kn(rdquoint Fpn Exportrdquo)
(rdquoint Fpn Exportrdquo) + [intFpn]n(rdquoint Fpn Exportrdquo)
middot [intLIP]
)
+[intDMT1] middot C(rdquoint Iron Import DMT1rdquo) middot [gutFe2]
K(rdquoint Iron Import DMT1rdquo) + [gutFe2]
+[rdquointHOminus 1rdquo] middot C(rdquoint Heme Oxygenationrdquo) middot [intHeme]
K(rdquoint Heme Oxygenationrdquo) + [intHeme]
minus k1(rdquoint outflowrdquo) middot [intLIP]
minus k1(rdquoint Fe2 oxidation by H202rdquo) middot [intLIP] middot [intH202]
minus(k1(rdquoint Fe2 PD2 bindingrdquo) middot [intLIP] middot [intPD2]minus
k2(rdquoint Fe2 PD2 bindingrdquo) middot [rdquointPD2minus Fe2rdquo])
+(k1(rdquoint Fe3 reduction by AS and O2rdquo) middot [intFe3] middot [intO2] middot [intAS]
)(A039)
d ([intDMT1] )
dt= minus k1(rdquoint Dmt1 Degradationrdquo) middot [intDMT1]
+a2(rdquoint DMT1 Expressionrdquo) middot [intH2alpha]n(rdquoint DMT1 Expressionrdquo)
K2(rdquoint DMT1 Expressionrdquo)n(rdquoint DMT1 Expressionrdquo) + [intH2alpha]n(rdquoint DMT1 Expressionrdquo)
+a(rdquoint DMT1 Expressionrdquo) middot [intIRP]n(rdquoint DMT1 Expressionrdquo)
K(rdquoint DMT1 Expressionrdquo)n(rdquoint DMT1 Expressionrdquo) + [intIRP]n(rdquoint DMT1 Expressionrdquo)
(A040)
188
d ([intIRP] )
dt=
+ a(rdquoint IRP Expressionrdquo) middot
(1 minus [intLIP]n(rdquoint IRP Expressionrdquo)
Kn(rdquoint IRP Expressionrdquo)
(rdquoint IRP Expressionrdquo) + [intLIP]n(rdquoint IRP Expressionrdquo)
)minus k1(rdquoint IRP degradationrdquo) middot [intIRP]
(A041)
d ([intFpn] )
dt=
+ a(rdquoint Ferroportin Expressionrdquo) middot
(1 minus [intIRP]n(rdquoint Ferroportin Expressionrdquo)
Kn(rdquoint Ferroportin Expressionrdquo)
(rdquoint Ferroportin Expressionrdquo) + [intIRP]n(rdquoint Ferroportin Expressionrdquo)
)
minus a(rdquoint Fpn degradationrdquo) middot[intHamp]n(rdquoint Fpn degradationrdquo)
Kn(rdquoint Fpn degradationrdquo)
(rdquoint Fpn degradationrdquo) + [intHamp]n(rdquoint Fpn degradationrdquo)middot [intFpn]
(A042)
[intHamp] = [Hamp]
(A043)
d ([intHeme] )
dt=+
(V(rdquogutHeme uptakerdquo) middot [gutHeme]
Km(rdquogutHeme uptakerdquo) + [gutHeme]
)minus(
V(rdquoint Heme Exportrdquo) middot [intHeme]
Km(rdquoint Heme Exportrdquo) + [intHeme]
)minus([rdquointHOminus 1rdquo] middot C(rdquoint Heme Oxygenationrdquo) middot [intHeme]
K(rdquoint Heme Oxygenationrdquo) + [intHeme]
)
(A044)
d ([rdquointFeminus FTrdquo] )
dt=+ k1(rdquoint Ferritin Iron bindingrdquo) middot [intLIP] middot [intFT]
minus k1(rdquoint Ferritin Iron internalisationrdquo) middot [rdquointFeminus FTrdquo]
minus k1(rdquoint Ferritin Iron releaserdquo) middot [rdquointFeminus FTrdquo]
(A045)
189
APPENDIX A LIST OF EQUATIONS
d ([intFT] )
dt=minus k1(rdquoint Ferritin Degradation Fullrdquo) middot [intFT]
+ a(rdquoint ferritin expressionrdquo)
middot
(1 minus [intIRP]n(rdquoint ferritin expressionrdquo)
Kn(rdquoint ferritin expressionrdquo)
(rdquoint ferritin expressionrdquo) + [intIRP]n(rdquoint ferritin expressionrdquo)
)minus k1(rdquoint Ferritin Iron bindingrdquo) middot [intLIP] middot [intFT]
+ k1(rdquoint Ferritin Iron internalisationrdquo) middot [rdquointFeminus FTrdquo]
+ k1(rdquoint Ferritin Iron releaserdquo) middot [rdquointFeminus FTrdquo]
(A046)
d ([intFT1] )
dt=minusK(rdquoint Ferritin Degredation Full Iron Releaserdquo) middot
[intFT1]
[intFT]middot [intFT]
minus [intFT1] middot kloss(rdquoint Ferritin internalised iron releaserdquo) middot
(1 +
0048 middot [intFT1][intFT]
1 + [intFT1][intFT]
)+ k1(rdquoint Ferritin Iron internalisationrdquo) middot [rdquointFeminus FTrdquo]
(A047)
d ([rdquointHOminus 1rdquo] )
dt=+
a2(rdquoint HO1 exprdquo) middot [intHalpha]n(rdquoint HO1 exprdquo)
K2n(rdquoint HO1 exprdquo)
(rdquoint HO1 exprdquo) + [intHalpha]n(rdquoint HO1 exprdquo)
+a(rdquoint HO1 exprdquo) middot [intHeme]n(rdquoint HO1 exprdquo)
Kn(rdquoint HO1 exprdquo)
(rdquoint HO1 exprdquo) + [intHeme]n(rdquoint HO1 exprdquo)
minus k1(rdquoint HO1 degrdquo) middot [rdquointHOminus 1rdquo]
(A048)
d ([intFe3] )
dt=+ k1(rdquoint Fe2 oxidation by H202rdquo) middot [intLIP] middot [intH202]
minus(k1(rdquoint Fe3 reduction by AS and O2rdquo) middot [intFe3] middot [intO2] middot [intAS]
)(A049)
190
[intH202] = [H202]
(A050)
d ([intHalpha] )
dt=
minus(k1(rdquoint Halpha bindingrdquo) middot [intHalpha] middot [rdquointPD2minus Fe2minusDGminusO2minus ASrdquo]
minus k2(rdquoint Halpha bindingrdquo) middot [rdquointHalphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo])
minus(k1(rdquoint Halpha binding without ASrdquo) middot [rdquointPD2minus Fe2minusDGminusO2rdquo] middot [intHalpha]
minus k2(rdquoint Halpha binding without ASrdquo) middot [rdquointHalphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo])
+ v(rdquoint Halpha expressionrdquo)
(A051)
d ([rdquointHalphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo] )
dt=
+(k1(rdquoint Halpha bindingrdquo) middot [intHalpha] middot [rdquointPD2minus Fe2minusDGminusO2minus ASrdquo]
minus k2(rdquoint Halpha bindingrdquo) middot [rdquointHalphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo])
+(k1(rdquoint Halpha binding without ASrdquo) middot [rdquointPD2minus Fe2minusDGminusO2rdquo] middot [intHalpha]
minus k2(rdquoint Halpha binding without ASrdquo) middot [rdquointHalphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo])
minus k1(rdquoint Halpha hydroxylationrdquo) middot [rdquointHalphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo]
(A052)
d ([intHalphaH] )
dt=
+ k1(rdquoint Halpha hydroxylationrdquo) middot [rdquointHalphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo]
minus k1(rdquoint HalphaH degradationrdquo) middot [intHalphaH]
(A053)
191
APPENDIX A LIST OF EQUATIONS
d ([inthydroxylRadical] )
dt=+ k1(rdquoint Fe2 oxidation by H202rdquo) middot [intLIP] middot [intH202]
minus k1(rdquoint hydroxylRadical to waterrdquo) middot [inthydroxylRadical]
(A054)
[intO2] = [O2]
(A055)
d ([intPD2] )
dt=minus
(k1(rdquoint Fe2 PD2 bindingrdquo) middot [intLIP] middot [intPD2]
minus k2(rdquoint Fe2 PD2 bindingrdquo) middot [rdquointPD2minus Fe2rdquo])
+ [intHalpha] middot K(rdquoint PD2 expressionrdquo)
(A056)
d ([rdquointPD2minus Fe2rdquo] )
dt=minus
(k1(rdquoint DG bindingrdquo) middot [intDG] middot [rdquointPD2minus Fe2rdquo]
minus k2(rdquoint DG bindingrdquo) middot [rdquointPD2minus Fe2minusDGrdquo])
+(k1(rdquoint Fe2 PD2 bindingrdquo) middot [intLIP] middot [intPD2]
minus k2(rdquoint Fe2 PD2 bindingrdquo) middot [rdquointPD2minus Fe2rdquo])
(A057)
d ([rdquointPD2minus Fe2minusDGrdquo] )
dt=+
(k1(rdquoint DG bindingrdquo) middot [intDG] middot [rdquointPD2minus Fe2rdquo]
minus k2(rdquoint DG bindingrdquo) middot [rdquointPD2minus Fe2minusDGrdquo])
minus(k1(rdquoint O2 Bindingrdquo) middot [intO2] middot [rdquointPD2minus Fe2minusDGrdquo]
minus k2(rdquoint O2 Bindingrdquo) middot [rdquointPD2minus Fe2minusDGminusO2rdquo])
(A058)
192
d ([rdquointPD2minus Fe2minusDGminusO2rdquo] )
dt=
minus(k1(rdquoint H2alpha binding without ASrdquo) middot [rdquointPD2minus Fe2minusDGminusO2rdquo] middot [intH2alpha]
minus k2(rdquoint H2alpha binding without ASrdquo) middot [rdquointH2alphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo])
minus((k1(rdquoint As bindingrdquo) middot [rdquointPD2minus Fe2minusDGminusO2rdquo] middot [intAS]
minus k2(rdquoint As bindingrdquo) middot [rdquointPD2minus Fe2minusDGminusO2minus ASrdquo]))
minus(k1(rdquoint Halpha binding without ASrdquo) middot [rdquointPD2minus Fe2minusDGminusO2rdquo] middot [intHalpha]
minus k2(rdquoint Halpha binding without ASrdquo) middot [rdquointHalphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo])
+(k1(rdquoint O2 Bindingrdquo) middot [intO2] middot [rdquointPD2minus Fe2minusDGrdquo]
minus k2(rdquoint O2 Bindingrdquo) middot [rdquointPD2minus Fe2minusDGminusO2rdquo])
(A059)
d ([rdquointPD2minus Fe2minusDGminusO2minus ASrdquo] )
dt=
minus(k1(rdquoint H2alpha bindingrdquo) middot [intH2alpha] middot [rdquointPD2minus Fe2minusDGminusO2minus ASrdquo]
k2(rdquoint H2alpha bindingrdquo) middot [rdquointH2alphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo])
+((k1(rdquoint As bindingrdquo) middot [rdquointPD2minus Fe2minusDGminusO2rdquo] middot [intAS]
minus k2(rdquoint As bindingrdquo) middot [rdquointPD2minus Fe2minusDGminusO2minus ASrdquo]))
minus(k1(rdquoint Halpha bindingrdquo) middot [intHalpha] middot [rdquointPD2minus Fe2minusDGminusO2minus ASrdquo]
minus k2(rdquoint Halpha bindingrdquo) middot [rdquointHalphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo])
(A060)
d ([intH2alpha] )
dt=
minus(k1(rdquoint H2alpha bindingrdquo) middot [intH2alpha] middot [rdquointPD2minus Fe2minusDGminusO2minus ASrdquo]
minus k2(rdquoint H2alpha bindingrdquo) middot [rdquointH2alphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo])
minus(k1(rdquoint H2alpha binding without ASrdquo) middot [rdquointPD2minus Fe2minusDGminusO2rdquo] middot [intH2alpha]
minus k2(rdquoint H2alpha binding without ASrdquo) middot [rdquointH2alphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo])
+ a(rdquoint H2alpha expressionrdquo) middot(1 minus [intIRP]
K(rdquoint H2alpha expressionrdquo) + [intIRP]
)
(A061)
193
APPENDIX A LIST OF EQUATIONS
d ([rdquointH2alphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo] )
dt=
+(k1(rdquoint H2alpha bindingrdquo) middot [intH2alpha] middot [rdquointPD2minus Fe2minusDGminusO2minus ASrdquo]
minus k2(rdquoint H2alpha bindingrdquo) middot [rdquointH2alphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo])
minus k1(rdquoint H2alpha hydroxylationrdquo) middot [rdquointH2alphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo]
+(k1(rdquoint H2alpha binding without ASrdquo) middot [rdquointPD2minus Fe2minusDGminusO2rdquo] middot [intH2alpha]
minus k2(rdquoint H2alpha binding without ASrdquo) middot [rdquointH2alphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo])
(A062)
d ([intH2alphaH] )
dt=
+ k1(rdquoint H2alpha hydroxylationrdquo) middot [rdquointH2alphaminus PHD2minus Fe2minus ASminusDGminusO2rdquo]
minus k1(rdquoint H2alphaH degradationrdquo) middot [intH2alphaH]
(A063)
194