A comparison of cerebral and venous microdialysis during experimental hypothermic antegrad cerebral perfusion. Authors: Jonsson O, Tovedal T, Zemgulis V, Lennmyr F, Hillered L, Thelin S. Department of Cardiothoracic surgery and anesthesiology Department of Neuroscience, Neurosurgery Uppsala University Uppsala University Hospital, Sweden
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A comparison of cerebral and venous microdialysis during experimental hypothermic antegrad cerebral perfusion. Authors: Jonsson O, Tovedal T, Zemgulis.
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A comparison of cerebral and venous microdialysis during experimental hypothermic antegrad cerebral perfusion.
Authors:Jonsson O, Tovedal T, Zemgulis V, Lennmyr F, Hillered L,
Thelin S.
Department of Cardiothoracic surgery and anesthesiologyDepartment of Neuroscience, Neurosurgery
Uppsala University Uppsala University Hospital, Sweden
SACP Selective Antegrade Cerebral Perfusion
A Carotis communis
Aortic cannula
Clamps
Microdialysis
Lactate/pyruvate
Lactate/glucose
Background
• To encircle any signs of energy metabolic crisis and cellular distress during SACP flows between 6 ml/kg/min and 4 ml/kg/min.
• Can intravenous microdialysis in the sagittal sinus reveal global cerebral metabolic changes not detected by the brain microdialysis catheter.
Aims
• To investigate the effects of two SACP flow levels (6 and 4 ml/kg/min) on the development of cerebral ischemia.
• To evaluate the agreement and correlation between microdialysis markers harvested from the brain and the sagittal sinus.