Page 1 Med Chem Res 14:3 (2005) 169–179� Birkhauser Boston 2005Page 2 170Page 3 171Page 4 172Page 5 173Page 6 174Page 7 175Page 8 176Page 9 177Page 10 178Page 11 Received: 10-06-04 Accepted: 08-26-05 179