Stakeholders at stake in implementing personalized healthcare Prof Alain van Gool Bootcamp Student meets innovation 27 Nov 2015
Feb 12, 2017
Stakeholders at stake in implementing personalized healthcare
Prof Alain van Gool
Bootcamp Student meets innovation 27 Nov 2015
My background
8 years academia (NL, UK)
(molecular mechanisms of disease)
13 years pharma (EU, USA, Asia)
(biomarkers, Omics)
4 years med school (NL)
(personalized healthcare, Omics, biomarkers)
4 years applied research institute (NL, EU)
(biomarkers, personalized health, nutrition)
A person / citizen / family man
(adventures in EU, USA, Asia)
1991-1996 (PhD)
1996-1998 (post-doc)
2009-2012 (visiting prof)
1999-2007 2007-2009 2009-2011
2011-now
2011-now (prof)
2
Professor of Personalized Healthcare Head Radboud Center for Proteomics, Glycomics and Metabolomics Coordinator Radboud Technology Centers
Senior Scientist Integrator Biomarkers
Collaboration towards teamwork
3
• Not easy to achieve
• If done well: great energy, good focussed output
• If done badly: ineffective, no desired output
Collaboration starts with understanding
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• Stakeholders can have (very) different interests, motivations, struggles
• Select your discussion partner
• Know his/her background
• Respect
• Discuss with open questions
• Listen, Learn, Adapt
• Be open for input & critisism
• Maintain big picture goal
• Aim for 1+1=3
Semantics
5
Translational science
• Molecular Biologist - Biochemistry to cell
• Pharmacologist - Cell to animal
• Clinical pharmacologist - Animal to man
• Clinician - Healthy person to patient
• Enterpreneur - Innovation beta version to product
Preclinical Clinical
• Cell, animal - Man
• Healthy person - Patient
• Research - Implemented product
Semantics
6
Intervention
• Pharmaceutical drug developer - Drug
• Psychologist - Provide right information to individual so he/she can take better informed decision about own health
Innovation
• Patent
• New product
• New implemented procedure
Part of my world • Glycoproteomics profiling in plasma • Detection of ~12.000 unique deconvoluted monoisotopic masses
per single analysis (> 50% are glycopeptides)
500
1000
1500
2000
m/z
5 10 15 20 25 30 35 40 Time [min]
Proof of principle study:
7
Part of my world
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Systems biology view on metabolic health and disease to map pharma-nutrition effects
Part of my world
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Radboudumc Technology Centers
About 250 dedicated people working in 18 Technology Centers, ~2000 users (internal, external), ~140 consortia www.radboudumc.nl/research/technologycenters/
Different worlds: molecular biologist and patient
“I’m afraid you’re
suffering from an
increased IL-1β and
an aberrant miR843
expression”
Adapted from:
?
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People are more than molecular pathways
Source: Barabási 2007 NEJM 357; 4}
• People are different • Different networks and influences • Different risk factors • Different preferences
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Personalized Healthcare @ Radboudumc
People are different Stratification by multilevel diagnosis
+ Patient’s preference of treatment
Exchange experiences in care communities Select personalized therapy
Population
Man
Molecule
Alain van Gool, Workshop Neuroinformatics and personalized health care , Nijmegen, 26 Nov 2015 13
Lab values Clinical outcomes
Pain Mobility Fatigue
INTEGRATE-HTA
Objectives patient and clinican may be different
R van Hoorn, W Kievit, M Tummers, GJ van der Wilt
How to do optimal shared decision making?
Intervention
Minor Personalized Health(care)
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• Opinion: Team work is only possible when you understand your partner’s motivation
• Task: get to know the stakeholders in Personalized Health(care)
o Patient o Clinician o Nurse o Basic researcher o Applied researcher o Care provider o Health insurer o Pharmaceutical developer o Nutrition developer o Health economist Teams Background check 10 Question-based interviews
Minor Personalized Health(care)
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• Task: pitch your 2025 innovation in Personalized Health(care)
+ involvement of stakeholders
Collaboration starts with understanding
24
• Stakeholders can have (very) different interests, motivations, struggles
• Select your discussion partner
• Know his/her background
• Respect
• Discuss with open questions
• Listen, Learn, Adapt
• Be open for input & critisism
• Maintain big picture goal
• Aim for 1+1=3
Available as innovation expert
Personalized Healthcare
Biomarkers
Molecular biology
Genomics / proteomics
www.radboudumc.nl/personalizedhealthcare
www.radboudumc.nl/research/technologycenters
www.radboudresearchfacilities.nl
www.linkedIn.com
www.slideshare.net/alainvangool
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Collaboration
Communication
Innovation
Validation
Pharmaceutical industry
Academia
Hospital
Spin-off companies