Top Banner
1 | 2011 White-Line – revolutionary concept for very small lots facts KöRBER MEDIPAK - Customer Magazine
11

1 | 2011 revolutionary concept facts Customer Magazine2011 facts 03 Contents editorial Körber MedipaK Group 04-08 Seidenader: enlargement and expansion for KÖRBER MEDIPAK Interpack

Apr 25, 2018

Download

Documents

phamnhu
Welcome message from author
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Page 1: 1 | 2011 revolutionary concept facts Customer Magazine2011 facts 03 Contents editorial Körber MedipaK Group 04-08 Seidenader: enlargement and expansion for KÖRBER MEDIPAK Interpack

1 | 2011 White-Line – revolutionary concept for very small lots fa

cts

rb

er

Me

dip

aK

- Cus

tom

er M

agaz

ine

Page 2: 1 | 2011 revolutionary concept facts Customer Magazine2011 facts 03 Contents editorial Körber MedipaK Group 04-08 Seidenader: enlargement and expansion for KÖRBER MEDIPAK Interpack

031 | 2011 facts

editorialContents

Körber MedipaK Group 04 - 08Seidenader: enlargement and expansion for KÖRBER MEDIPAK

Interpack 2011: Technological highlights for integrated packaging solutions

We’d like you to meet … 05the management of Seidenader Maschinenbau GmbH

Show previews 2011 09

MediSeal 10 - 13White-Line by MediSeal – Revolutionary supply chain concept for very small lots

rondo 14 -15More safety in the box

dividella 16 -19How can the sustainability of pharmaceutical packaging be measured?

New to our team 19

approaches, the problem of very small lots is solved by further development of the production process and an optimised sup-ply chain, providing a comprehensive Small Lot Solution. The modular system allows packaging of a pharmaceutical product in a single production process, without the time-consuming and expensive machine changeovers for specific national mar-kets which would otherwise be necessary. This means that our customers can save a lot of time and money.

The ongoing social trend towards greater sustainability is placing ever more demands on packaging – the ecological footprint is now an important consideration for many companies when they devel-op and manufacture new products. The study carried out by our colleagues at Dividella shows how sustainability can be measured with regard to pharmaceutical packaging and that ecological and economic needs are not contradictory but actually complement each other.

The security of packaging also remains an important issue – tamper protection and tamper evidence are just two of the key concepts. With its innovative patented “folding box with Tamper Evidence”, Rondo has not only developed an effective means of protection but also keeps costs low and plant efficiency high.

I am especially pleased today to be able to introduce you to the SEIDENADER Group. Since the beginning of this year the compa-nies, which specialise among other things in inspection machines and Track &Trace solutions, have been members of the KÖRBER

MEDIPAK Group. This allows us to offer our customers an even broader range of services and an expanded presence in the mar-kets, with new opportunities for cooperation. It only remains for me to wish you an enjoyable read!

My very best wishes,

Gerhard Breu

The changes in the pharmaceutical market demand ever greater efficiency and flexibility, especially in the packaging process. Con-ventional machine optimisation and line optimisation techniques are no longer sufficient to offset the sometimes massive decline in productivity due to shrinking lot sizes. MediSeal‘s LSC® – Late Stage Customization – concept already provides an opportunity to combine small packaging batches and then to customize them in a decoupled secondary packaging process, thereby increasing OEE by up to 25 %.

With White-Line, MediSeal is further extending this concept to create a new, forward-looking packaging and logistics concept for lot sizes from 1 to 2000 blisters. In contrast to conventional

dear Customers,

Page 3: 1 | 2011 revolutionary concept facts Customer Magazine2011 facts 03 Contents editorial Körber MedipaK Group 04-08 Seidenader: enlargement and expansion for KÖRBER MEDIPAK Interpack

04 facts 1 | 2011 051 | 2011 facts

We’d like youto meet …

Nik Seidenader Managing Director of Seidenader Maschinenbau GmbH

Nik Seidenader (50) is Managing Director of Seidenader Maschinenbau GmbH, Markt Schwaben near Munich, and is responsible for sales and marketing. Before starting with Seidenader he worked for Bain & Co., a management consulting group, in their offices in Boston, London, Paris and Munich on projects in the glass, packaging materials and automotive industry, as well as in the retail industry. He worked on several M&A projects, and on strategic reorientations of big international group of companies. Nik Seidenader graduated as Diplom-Kaufmann (MBA) from Ludwig-Maximilians-University in Munich, with focus on international marketing and strategic manage-ment. He also studied art history, political science and psychology. He is member of the IPDA (Parenteral Drug Association), the organization where industry giants meet to discuss trends in the pharmaceutical industry, equip-ment and process technologies.

Volker Wedershoven Managing Director of Seidenader Maschinenbau GmbH

Volker Wedershoven (51) is Managing Director of Seidenader Maschinenbau GmbH, Markt Schwaben near Munich, and is responsible for finances, engineering and company orga-nisation. In the course of the expansion of the Seidenader group, he is also responsible as Managing Director for the companies Seidenader Vision GmbH and Seidenader Präzi-sionstechnik GmbH. Volker Wedershoven studied Business Administration at the University Passau and Ludwig- Maximilians-University in Munich, where he graduated as Diplom-Kaufmann (MBA) from, with focus on taxes/account-ing and private law. In 1987 he joined Seidenader as Assis- tant to the Managing Director, took responsibility for differ-ent departments until announced Managing Director 1993.

Körber MedipaK Group

With the acquisition of the Seidenader Group, which specialises in inspection solutions, KÖRBER MEDIPAK is significantly enhancing its expertise in the area of pharmaceutical packaging systems. The inspection and Track&Trace systems for the health-care industry are an important and very promising addition to the range of services we provide.

Seidenader, based in Markt Schwaben near Munich, is a leading global manufacturer of inspection equipment, software and vision applications for pharmaceutical production. Vials, pre-filled syringes and ampoules are checked for product contamination, cosmetic defects and correct level. There is a wide range of models available, from a table top device for random sampling to a camera-based high-performance machine with a throughput of up to 36,000 containers per hour. Both liquid and freeze-dried products are inspected. The range also includes exterior cleaning and drying machines, sorting and grading machines for tablets and dragees, and cleaning and polishing machines for hard gelatine capsules.

More than a century of innovation in the market

Seidenader have been developing machinery of outstanding quality for more than 115 years. This extraordinary wealth of experience enables the company to offer a full range of models to suit every requirement. A glance at the current Series VI in the high-performance inspection sector reveals some in-novative elements for the parenteral products sector in terms of particle inspection and the detection of cosmetic defects such as scratches or cracks in the sidewall. The key factor is the modular design of the equipment, which enables custo-mised machines to be designed to meet specific customer requirements. A new, patented system ensures transport at maximum speed with minimum product spacing. In this way, products are fed in, separated and then individually inspected. Production takes place in a new building which was expanded a few years ago to an area of 4500 square metres. In addition to its machine-building activities, Seidenader also specialises in business sectors which are directly related to the stringent quality requirements of the pharmaceutical industry: Seiden-ader Vision GmbH provides image processing solutions and

customised inspection applications. Of particularly importance in terms of quality and safety: the development of the company's own Track&Trace systems enables product to be tracked to the patient and prevents not only counterfeiting of medicines but also confusion between products. Alongside Seidenader Automation GmbH as software developer, the group's product range also includes programming and integration of software solutions, e.g. console systems, PLC programming and visualisation software. Finally, Seidenader Präzisionstechnik GmbH specialises in the production of precision mechanical parts and module assembly.

an ideal match: growing together

Seidenader and KÖRBER MEDIPAK complement each other perfectly: many additional joint development and growth opportunities will be generated in the future. Some of the Seidenader products complement the offerings available from our Dividella and MediSeal divisions – but many products are successful in the market quite independently,” says Gerhard Breu, KÖRBER MEDIPAK's CEO. “The acquisition of Seidenader is part of our consistent commitment to our customers as a systems provider for integrated packaging solutions and technologies.”

In the past there have regularly been joint projects with MediSeal and Dividella, so the companies already know each other. This means that in the future cus-tomers will benefit even more from the transfer of know-how and the resulting innovative applications and integrated solutions for the pharmaceutical industry. At the same time, the KÖRBER MEDIPAK Group's presence in world markets continues to grow.

Despite all the changes and the successful ongoing integration process, Seiden-ader remains an independent company; the existing corporate and management structure will remain intact. Nik Seidenader and Volker Wedershoven remain as directors at the head of the Seidenader companies. All of Seidenader's 360 or so employees will continue to work at the sites in Germany and the USA. Nor will the production program be affected by the company's membership of the KÖRBER MEDIPAK Group.

However, there will still be two separate stands at Interpack in Düsseldorf (12 to 18 May): KÖRBER MEDIPAK will be found in Hall 16, Stand A25/B26, with Seidenader not too far away, also in Hall 16 on stand B47. A shared cor-porate image, however, is the first step towards togetherness!

Seidenader: enlargement and expansion for Körber MedipaK

“We are overjoyed that we can expand our activities in the healthcare market of the future with Seidenader, an innovative company with some very exciting technologies.” This was how Richard Bauer, head of Körber, welcomed the new acquisition to the group at the end of last year. Today we would like to introduce the Seidenader Group and outline for you the possibilities of future cooperation with KÖRBER MEDIPAK.

Page 4: 1 | 2011 revolutionary concept facts Customer Magazine2011 facts 03 Contents editorial Körber MedipaK Group 04-08 Seidenader: enlargement and expansion for KÖRBER MEDIPAK Interpack

0706

interpack 2011: Technological highlights for integrated packaging solutions

Once again this year, the KÖRBER MEDIPAK companies are appearing together at Interpack. In Hall 16, Stand A25/B26, Rondo, Dividella and MediSeal will be presenting technological innovations which set the standard for pharmaceutical packaging in terms of efficiency, flexibility and reliability. Seidenader will also be present, in Hall 16 on Stand B47, with its latest inspection and Track&Trace solutions.

Highlight: The “ White-Line” concept

Specifically for lot sizes in the 1-2000 blister range, MediSeal, with its innovative White-Line concept, demonstrates an entirely new approach by revolutionizing the supply chain on all levels – in a single step, all individual country variants can be combined into one batch.

Higher plant efficiency and lower production costs

The advantages of White-Line production are impressive. Initial customer experience shows that small lots which previously took 4 days to produce owing to the long changeover times can now be processed in just one day. The concept also allows an extremely fast time-to-market, as production can be started almost immedi-ately after receiving national approval. No lead time for individual films, leaflets and folding boxes is needed, as only an electronic layout is required. This results not only in time savings but also lower storage costs. Also, thanks to demand-based just-in-time production of the lot, the storage and depreciation costs for stored “residual lots” are reduced.

dividella: NeoTOp 804 TopLoad cartoner with Triple-Mode

features high flexibility

The focus this time is on the NeoTOP 804 packaging line. The technical design of the NeoTOP 804 fully meets the requirements of many customers who wish to stack multiple products in the same pack. The concept of the NeoTOP 804 has been extended to include triple-mode configuration for the same economic and flexible packaging of individual products. This unique enhance-ment enables highly flexible operation, as the NeoTOP 804 can be operated in either Single Mode or Triple Mode. The Dividella NeoTOP 804 on show has a capacity of up to 240 cartons per mi-nute in triple mode and packs pre-filled syringes, vials and a pack insert in a combined pack. The NeoTOP 804 has been specifically designed for applications for which a high degree of flexibility is required and where particularly high output has to be achieved.

MediSeal pUMa300: Combining efficiency and flexibility

With the PUMA300, MediSeal has developed a blister line which combines maximum efficiency, outstanding flexibility and future-proofing: product excellence, upgradeability, modularity and adapt-ability – these are the key features of the PUMA300. Thanks to the consistent use of servo technology, the number of format parts

is reduced to a new industrial reference value, reducing life-cycle costs and production costs. The unique modular concept allows plate-type sealing to complement or replace the standard roller-type sealing, as required. Shortened cleaning time and fast change-over make the PUMA300 extra efficient.

La600 Sp stick pack machine

This high-speed stick pack machine has been specially designed for the pharmaceutical market. The LA600 SP machine featured at Interpack produces more than 600 stick packs per minute on ten tracks and has an extremely small footprint of approximately five square metres.

Also not to be missed at Interpack: the LA160 edge-seal sachet machine – a compact (1 m²) and highly versatile machine. The LA160 is the ideal entry-level model for packaging all pharma-ceutical and cosmetic products.

Körber MedipaK Group

register online and secure your admission voucher!www.koerber-medipak.com/interpack

Körber MedipakHall 16, Stand a25/b26

SeidenaderHall 16, Stand b47

rondo aGHall 7.1., Stand d28

facts 1 | 2011 1 | 2011 facts

Page 5: 1 | 2011 revolutionary concept facts Customer Magazine2011 facts 03 Contents editorial Körber MedipaK Group 04-08 Seidenader: enlargement and expansion for KÖRBER MEDIPAK Interpack

0908

Show previews 2011

interpack May 12 – 18 | Düsseldorf (Germany)

FCe pharma May 24 – 26 | Saõ Paulo (Brazil)

paCKex internationalJune 21 – 23 | Toronto (Canada)

packexpo Las Vegas September 26 – 28 | Las Vegas (USA)

interphex prOctober 20 – 21 | San Juan (Puerto Rico)

Chinapharm October 25 – 28 | Shanghai (China)

expoquimia 2011 November 14 – 18 | Barcelona (Spain)

pharmtech November 22 – 25 | Moscow (Russia)

p-MeC indiaNovember 30 – December 02 | Mumbai (India)

packaging from rondo – for increased security

The Rondo company specialises in packaging development and packaging materials. In addition to its tried-and-tested products, at Interpack Rondo is focussing above all on the theme of packaging security. The new patented Pharma DDS (Discrete Dose Slider) child-resistant pack, which has been jointly developed with Stora Enso, is particularly suitable for packaging for clinical trials. With Rondo‘s likewise patented Tamper Evidence® packaging, tamper evidence is integrated into the box.

Seidenader: robot-assisted inspection

Among other things, Seidenader will be launching its new robot-assisted RIM inspection machine at Interpack. The RIM machine has been designed specifically for small batch production, e. g. in the product development environment or in clinical trials, or

for products for which automated inspection is preferred because of the nature of the product. Pressure measurement in vials: to pro-tect patients, the FDA demands full integrity of the pharmaceu-tical container and seal. The Seidenader HSA system measures the pressure in the vial or the oxygen content and can therefore relia-bly detect leaking containers-inline, at up to 600 containers/min.

Visit us at Interpack and see for yourself the top quality and out-standing technology of our machines and services.

We look forward to talking with you!

Seidenader riM robot-assisted inspection machine

Körber MedipaK Group

facts 1 | 2011 1 | 2011 facts

Page 6: 1 | 2011 revolutionary concept facts Customer Magazine2011 facts 03 Contents editorial Körber MedipaK Group 04-08 Seidenader: enlargement and expansion for KÖRBER MEDIPAK Interpack

1110

MediSeal

White-Line by MediSeal – revolutionary supply chain concept for very small lots

The trend towards smaller lot sizes is one which has become apparent in recent years and which will continue to grow. Units of up to 20 000 blisters are as a rule considered to be small lots, where the scale extends down to a lot size of one.

The LSC®-Late Stage Customization concept – which MediSeal has been offering since 2005 – consists of a variant of partially decoupled proces-ses, so that the blistering, cartoning and printing stages can be carried out independently of each other. This makes it possible to combine small packaging lots on the blister machine and then to customize them in a downstream, decoupled secondary packaging process.

a completely new and innovative packaging

and logistics concept

This concept has now been refined and developed consistently. Specially designed for lot sizes in the range from 1 to 2000 blisters, the White -Line by MediSeal concept constitutes a brand new and in-novative approach which revolutionises the entire supply chain within the company:

The cause is the increasing competition between pharmaceutical companies in the traditional thera-peutic sectors. For this reason, markets which were previously considered too small to be profitable are now being examined more closely. The development of new drugs in new, specific therapeutic areas with a smaller number of potential patients is also be-coming an area of growing interest. For the conven- tional packaging process, however, small lot sizes can mean a massive decline in productivity. Because of the rapidly increasing number of format changes, the efficiency of the packaging lines drops and so the cost per unit of production rises disproportion-ately. Even though constant improvements are being made in terms of conversion, cleaning and clearing processes, the improvements which are achieved are not sufficient in and of themselves to solve the problem of lots which are getting smaller and smaller.

All the different country variants are combined into one batch. This enables a change of country variant during a production run within less than fifteen minutes. The production of these “combined batches” takes place within spe-cific, predefined time frames. This eliminates storage, because, depending on the needs of a particular country, the total lot size can be adjusted individu-ally. To achieve these time savings, the production process must naturally apply new procedures. For example, all country-specific elements are “white”, i. e. they are brought onto the line unprinted and then printed inline.

This is what it looks like in detail: Blister printing uses two printers: one device applies a 2D code using UV printing for blister identification, whilst another unit prints the product information in black. To print the leaflet insert, blank paper from the roll is used – one printer respectively prints the front and back. Up to 30 leaflets per minute can be produced. The boxes are usually already printed with the logo and other non-country-specific data. The in-line printing is carried out by four printers in series: one black printer for the front and back, one printer for red, and one printer for application of the Braille text.

By consolidating different country variants, total production time

can be reduced by up to a third.

facts 1 | 2011 1 | 2011 facts

Page 7: 1 | 2011 revolutionary concept facts Customer Magazine2011 facts 03 Contents editorial Körber MedipaK Group 04-08 Seidenader: enlargement and expansion for KÖRBER MEDIPAK Interpack

12 facts 1 | 2011 131 | 2011 facts

Security through specialised inspection systems

In order to guarantee pharmaceutical safety, multiple inspection systems must be installed on the line to check each blister, each leaflet and each box separately. The three camera systems for the blister printing area verify that each blister is completely filled and inspect the UV code and the black print. Two cameras are used to check the leaflet insert, one for the front and one for the back. The same applies to the box printing: one camera checks the top of the box and another the bottom, and a third checks the Braille text. The biggest challenge is to check the leaflet insert, because this is where the information density is very high. Here a line-scan camera approximately 4,000 pixels wide is used, generating an image with more than 20 megapixels.

All the print data is provided in the form of PDF documents: one document each for the blister, the leaflet and the print on the box. This information is managed in the customer‘s ERP system; an LMS (Line Management System) is used as the interface with the printers and inspection systems on the packaging machine. The line itself consists of a CP400 blister machine with an integrated P1600 cartoner, plus an attached weighing system and a table

for manual packing. A BIB-BOB module for tidy stacking of the blisters in a hopper can be fitted as an option. Final packaging is not needed for these very small lots. However, the White-Line does not necessarily have to be connected to a blister machine. In the case of a decoupled blister process and packaging process, the blisters have to be provided with blank film and a code system.

“Fundamental optimisation of the supply chain”

The advantages of White-Line production are impressive. Initial customer experience shows that small lots which previously took 4 days to produce owing to the long changeover times can now be processed in just one day. But it is not only line efficiency which can be improved dramatically. The concept also allows for an extremely fast time-to-market, as production can be started almost immediately after receiving national approval. No lead time for individual films, leaflets and folding boxes is needed, as only an electronic layout is required. This results not only in time savings but also lower storage costs. If the layout changes, existing inven-tory no longer has to be destroyed. Also, thanks to demand-based just-in-time production of the lot, the storage and depreciation costs for stored “residual lots” are reduced.

“With the White -Line we address and solve problems associated with small lots not through machine optimisation, but through further development of the entire production process and, above all, fundamental optimisation of the supply chain”, says Stephan Plewa, CEO of MediSeal GmbH. “In close cooperation with our customers we can achieve benefits which are impossible with traditional packaging lines.”

This year, the White-Line is also the centrepiece of our presence at Interpack! Visit us in Hall 16, Stand A25/B26!

MediSeal

blister printing: The blisters are printed individually using the DoD (“drop on demand”) method.

blank leaflet: After printing the front and back, the leaflet is folded and conveyed to the cartoning machine.

On the MediSeal White-Line, lot sizes from 1 to 2000 blisters

can be packaged.

Page 8: 1 | 2011 revolutionary concept facts Customer Magazine2011 facts 03 Contents editorial Körber MedipaK Group 04-08 Seidenader: enlargement and expansion for KÖRBER MEDIPAK Interpack

1514

a high degree of effectiveness at low cost

Neither material costs nor investment costs are incurred with Rondo‘s patented “folding box with Tamper Evidence”, as it involves neither security labels nor glue. The principle is rela-tively simple but still offers effective and visible protection. During the sealing process, cut-outs are included in the bottom and top flaps; these clearly and irreversibly indicate the first opening of the box. At first glance, the consumer can see from the break in the perforation whether the packaging is intact or if it has been tampered with. For the product manufacturer, Rondo Tamper Evidence also offers other advantages compared with other methods: Existing cutting tools can be used and slightly modified for the punching process. The blanks can be erected, filled and sealed on existing packaging lines. Nor is the packing rate affected by the Tamper Evident solution. Opening and resealing is just as simple and easy as it is with Rondo‘s conventional folding boxes. Even the design of the box benefits from the innovative Tamper Evident solution, as text and logos are not covered by a label.

applications in various fields

“There is no absolute security against counterfeiting and tam-pering,” stresses Staub. “Nevertheless, the manufacturer can make a major contribution to improving product safety with our

innovative solution and can offer added-value to retailers and consumers”, he notes. Staub sees possible applications for the new folding box with Tamper Evidence in many different areas. There is potential, for example, in the area of OTC products, which are increasingly being sold by drugstores and supermarkets, depending on the respective national legislation. This means that such items are accessible without restrictions to a much wider public, with the resulting greater security risks. But Rondo‘s Tamper Evidence will also be of interest in the case of cosmetics and prescription drugs which are at high risk of counterfeiting.

“The greatest protection against counterfeiting and tampering is very important for our customers. The development of new, effective safety solutions is therefore a real customer need,” says Dr. Markus Staub, Rondo AG‘s CEO. Rondo Tamper Evidence, a patented folding box, is the latest product from the Rondo Innovation Centre and sets new standards in safety. The innova- tive packaging offers much more than a standard folding box can usually provide. Unlike traditional boxes, the tamper protection is integrated directly into the packaging.

Traditional solutions using labels and stickers

Currently, there are two main solutions in use to protect folding boxes from counterfeiting or tampering. One works with sealing labels which have a hologram and which can be stuck onto the flap of the box. The holograms, which are now no longer conside-red to be absolutely impossible to counterfeit, generate additional procurement and management costs. Also, the application pro-cess in the packaging line reduces line speed, thereby reducing productivity and efficiency. Another, more expensive security method is the direct bonding of the flap to the box. In this case, as well as the gluing machine, the manufacturer also needs an additional application unit which has to be integrated into the line and which involves investment costs. Here too, the gluing process has a negative effect on the efficiency of the packaging process.

rondo

More safety in the box

Occurrences of product tampering with food and beverages, as well as cosmetics and pharmaceutical products, always generate public headlines. They confuse consumers and create a risk for manufacturers and retailers which should not be underestima-ted. With Rondo Tamper Evidence, Körber Medipak’s Swiss subsidiary company Rondo has developed a folding box with integrated tamper evidence.

Consign product tampering to the past with the innovative rondo Tamper evidence folding box

facts 1 | 2011 1 | 2011 facts

Page 9: 1 | 2011 revolutionary concept facts Customer Magazine2011 facts 03 Contents editorial Körber MedipaK Group 04-08 Seidenader: enlargement and expansion for KÖRBER MEDIPAK Interpack

16 facts 1 | 2011 171 | 2011 facts

environmental life cycle assessment

Concepts such as the ecological footprint are doubtless very interesting, but they do not help us to assess the environmental impact which is generated by a single product throughout its life cycle. To do this we must go one step further and apply what is known as the ecological life cycle assessment (LCA) method. LCA is the model for the complex interaction between a particular product and its environment ’from cradle to grave‘.

Step 1 – Inventory (LCI - life cycle inventory): describes the emissions which occur and the raw materials which are used during the life cycle of a product. To make the comparison as objective and scientific as possible, commercially available software was used. 1

Step 2 – Assessment: A listing of the impact of these emissions and of the depletion of raw materials.

Using the widely recognised Eco-indicator 99 method 2, the damage caused by all the emissions calculated in step 1 to our ecosystems is measured. Finally, individual categories, such as CO2 emissions, can be compared.

Case study – NeoTOp packaging compared to a plastic tray

for a six-syringe pack

In this case study we examine the environmental impact caused by two different packs which serve precisely the same purpose in their life cycle – the delivery of six syringes to a hospital. The NeoTOP solution consists of two flat cardboard blanks which are erected automatically by the Dividella packaging machine. The other, more traditional packaging consists of a cardboard box and a plastic tray. The plastic tray is usually deep-drawn on a thermoforming machine and then placed in the cardboard box in the cartoner. For purposes of illustration, we have looked at plastic trays made from PVC and PP, in order to better clarify the differences between

different plastics. In this case, the aluminium tray serves only as a theoretical example, but can easily be applied to tablets, which are packaged in an aluminum blister.

In the scenario, the following aspects were considered:▪ Production of raw materials such as PVC, PP, PET and cardboard fibres▪ Manufacturing processes such as the production of card- board and plastic film▪ Energy consumption per pack by secondary packaging machines▪ Transport of cardboard and plastic over a distance of 100 kilometres to the pharmaceutical plant▪ End of life (landfill scenario)

The following aspects were not considered:▪ LCA of syringes and patient information, as these are the same for both solutions.▪ Transport from the pharmaceutical plant to end users. This subject is covered separately in the section on financial implications.

The life cycles were modeled in the SimaPro software and assessed according to the above-mentioned steps. Figure 1 illustrates the inventory stage and indicates the influence of any form of pack-aging on different environmental categories, such as “organic emissions” or “climate change”. The latter includes, for example, emissions such as carbon dioxide or methane gas. The results from the database show that the CO2 footprint of the NeoTOP solution over its entire life cycle amounts to about 18 grams of carbon dioxide, whilst the plastic solutions are at about 80 grams and aluminum is at the top of the scale at 155 grams. In short, even if we assume an error bar of 20 % in the modelling, the fac-tor for Toploading is 4 to 5 times better with regard to the carbon dioxide environmental indicator.

dividella

How can the sustainability of pharmaceutical packaging be measured?

Today, sustainability for many businesses is no longer just an ecological factor but also an important economic factor. This article indicates how sustainability in the production and transportation of packaging for pharmaceutical products has a positive impact on costs.

by Dr. Manfred Zurkirch, Dividella AG, Switzerland

Page 10: 1 | 2011 revolutionary concept facts Customer Magazine2011 facts 03 Contents editorial Körber MedipaK Group 04-08 Seidenader: enlargement and expansion for KÖRBER MEDIPAK Interpack

0.0

4.0

6.0

8.0

Carcinogens

10.0

2.0

Resp.organics

Resp.inorganics

Climatechange

Radiation Ozonelayer

Ecotoxicity Acidification/Eutrophication

Land use Minerals Fossil fuels

PVC Alu PP Topload

0.0

4.0

6.0

8.0

Carcinogens

10.0

2.0

Resp.organics

Resp.inorganics

Climatechange

Radiation Ozonelayer

Ecotoxicity Acidification/Eutrophication

Land use Minerals Fossil fuels

PVC Alu PP Topload

Figure 1: Comparison of different packaging materials and solutions in a wide range of environmental categories according to Step 1 of the LCA.

Figure 2: Comparison of overall environmental impact caused by the two different packaging solutions and different materials, measured in Eco-indicator 99 points.

18 facts 1 | 2011 191 | 2011 facts

dividella

New to the Team of the Körber MedipaK Group

Smaller packs versus More advertising spaceLighter materials versus Better product protectionHigh pack density versus Single doses of medicationHigher OEE versus Smaller lot sizesSize optimisation versus More patient information

However, Dividella has proved on numerous occasions that cost savings of 10 to 40 % are possible on packaging materials when switching from combination packs to NeoTOP solutions which consist entirely of cardboard. Savings of 10 to 20 % are possible if the size of the two solutions is similar, and 40 to 50% if the size can be optimised. Depending on the number of packs produced in a year, these recurring cost savings can be considerable.

Of course, the smaller size of the densely packed NeoTOP solution (thanks to the cardboard flutes preventing contact between the glass components) has a major effect on the transport costs of refrigerated goods. As an example, we have calculated the annual savings for a four-syringe pack (NeoTOP compared to a plastic tray in a side-loading box) which is currently on the market. If one assumes a volume of 2.5 million packs per year and an average shipment distance of approximately 2 600 km per vessel, the savings amount to about one million US dollars a year. For air transport of the same volume, these savings amount to about 10 million US dollars.

It goes without saying that the precise savings depend on the logistics, such as the type of transportation, distribution channel and network, and the number of packs. The above examples clearly show that material and trans-portation costs for solutions which are also environmentally sustainable can be considerably lower. For secondary packaging of pharmaceutical products, there has not so far been a single case in which the ecological and economic aspects contradict each other.

This article presents a method for analytical measurement the impact of different products and services on the environment. The LCA method allows customers to evaluate packaging solutions and to select those which reduce their own ecological footprint. In general, this environmental ranking goes hand in hand with the economic ranking. In other words: sustainable pack-aging solutions also bring significant cost savings.

1 SimaPro by PréConusultants (www.pre.nl)2 Eco-indicator 99 impact assessment method – report available at www.pre.nl

The next stage examines how the different solutions look from the viewpoint of their overall impact. In Figure 2 all emissions of all categories are evaluated against each other and summated to give a total score for each packaging solution. The total en-vironmental impact is measured using Eco-indicator points in accordance with the Eco-indicator method.

It is clear that the NeoTOP solution causes by far the least envi-ronmental damage. All other packaging solutions generate an environmental impact approximately 5 times higher. Of course, in the overall result many emissions are included; carbon dioxide is only a small factor, but an important one in the overall picture.

Financial implications of sustainable solutions

It is not particularly surprising that, as a general rule, more sus-tainable packaging also saves pharmaceutical companies money.On the one hand there is the cost of the packaging material. The less material used, e.g. an optimised size, the better the solution. Naturally, optimisation of size is not the only parameter in the development of pharmaceutical packaging. For each pack, there is always the challenge of weighing up different interests, some of which are in conflict, as shown below.

Martin MitullaProduct ManagerRondo AG

Martin Mitulla (43) joined Rondo AG, Allschwil, in Febru-ary 2011 as Product Manager. After studying International Relations in Geneva (HEI master’s degree), Mr Mitulla worked among other things as a product manager in the watch industry and in the investment goods department of the Post Office mail handling division. At Rondo AG, Mr Mitulla is responsible in particular for managing projects in the area of product innovation.

Jan NielebockProduct Manager MediSeal GmbH

Jan Nielebock joined MediSeal in April 2011 as Product Manager. After studying bioengineering and brewery technology he worked among other things for KHS GmbH. He brings wide experience in product management and R&D management.

Teresa (Terri) Westerhaug was appointed National Accounts Manager at Rondo-Pak, Inc., Norristown, Penn-sylvania/USA, December 2010. Terri has been in Sales and Strategic Business Development in the printing industry for over 25 years.

rick Leppert was appointed National Account Manager at Rondo-Pak, Inc., Norristown, PA/USA, a company belonging to the KORBER MEDIPAK Group in March 2010. Rick has over 20 years packaging experience and has worked most recently with Keller Crescent after a 20 year career with Rexam.

0.0

1.0

4.0

6.0

8.0

PVC PPAlu Topload

10.0

2.0

3.0

5.0

7.0

9.0

Page 11: 1 | 2011 revolutionary concept facts Customer Magazine2011 facts 03 Contents editorial Körber MedipaK Group 04-08 Seidenader: enlargement and expansion for KÖRBER MEDIPAK Interpack

facts 1 | 2011

carbon neutralnatureOffice.com | DE-142-653243

print production

publisher: Körber Medipak GmbH | Nagelsweg 33 - 35 | D-20097 Hamburg | T +49 40 211 07- 480 | F +49 40 211 07- 481 | [email protected] | responsible editor under German law: Gerhard Breu, CEO Körber Medipak | editor: Britta Riemann, Marketing

Körber MedipaK GmbH

Nagelsweg 33-35 | D-Hamburg | www.koerber-medipak.de

T +49 40 211 07-480 | F +49 40 211 07-481 | [email protected]

Körber MedipaK companies

rondo aG

Gewerbestraße 11 | CH-Allschwil | www.rondodruck.ch

T +41 46 486 87 87 | F +41 46 486 87 50 | [email protected]

dividella aG

Werdenstraße 76 | CH-9472 Grabs | www.dividella.com

T +41 81 750 33 66 | F +41 81 750 33 43 | [email protected]

MediSeal GmbH

Flurstraße 65 | D-33758 Schloss-Holte | www.mediseal.de

T +49 5207 888-0 | F +49 5207 888-299 | [email protected]

Seidenader Maschinenbau GmbH

Lilienthalstraße 8 | D-85570 Markt Schwaben | www.seidenader.de

T +49 8121 802-0 | F +49 8121 802-100 | [email protected]

Sales and Service companies

Körber MedipaK Na iNC.14501, 58th Street North | Clearwater, FL 33760 | USA | T +1 727 532 65 10 | F +1 727 532 65 37 [email protected]

Körber MedipaK France SarlEnergy Park 4 | 155 -159 rue du Dr. Bauer | 93400 Saint Ouen | France |T +33 140 11 40 11F +33 140 11 51 10 | [email protected]

Körber MedipaK Uk & rolMountbatton House | Fairacres | Windsor | Bershire SL4 4LE | UK | T +44 1753 75 48 65 [email protected]

Körber MedipaK asia-pacifikc/o Hauni Singapore Pte. Ltd. | 6 Temasek Boulevard 7 | #30-04 Suntec City Tower 4 | Singapore 038986T +65 68 35 98 86 | F +65 68 36 92 96 | [email protected]