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126 THE JOURNAL OF TAIWAN PHARMACY Vol.28 No.2 Jun. 30 2012
用 藥 安 全 Drug Safety
實例探討藥物引起 SJS 或 TEN 的評分方法 — Naranjo Score vs. ALDEN Score
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第28卷第2期Jun. 30 2012
實例探討藥物引起 SJS 或 TEN 的評分方法 — Naranjo Score vs. ALDEN Score
藥學雜誌 第111冊 131
Assessment Tools for Drug-Induced SJS or TEN by A Case Study — Naranjo Score vs. ALDEN Score
Department of Pharmacy, Chang Gung Memorial Hospital, Linkou1
Pharmacy Headquarters, Chang Gung Memorial Hospital2
Abstract
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe drug induced cutaneous adverse reactions, characterized by extensive detachment of epidermis and erosions of mucous membranes. Although rare, the death rate from epidermal necrolysis averages 23%. Hence, finding the culprit and avoiding to take place again are very important issues. In addition to the long term adopted Naranjo score to assess the causality of adverse drug reactions, ALDEN score also proved to be a useful assessment tool to evaluate the causality of drug induced epidermal necrolysis recently. We describe ALDEN score in detail and compare the assessment results of both tools applied through a real TEN case in this paper.