Transcript
FAT SOLUBLE FAT SOLUBLE VITAMINSVITAMINS
Dr Ayyub Patel, PhD CChem MRSC FRSC
Assistant Professor, Medicine KKU KSA
Lipid (FAT) solubleLipid (FAT) soluble Vitamins Vitamins
Retinoic acid -Vitamin ARetinoic acid -Vitamin A
Retinoic acid (Vitamin A)Retinoic acid (Vitamin A)• Active forms: Retinol, Retinal & Retinoic acid • Functions: Maintenance of reproduction Vision Promotion of growth Differentiation & maintenance of epithelial tissues Gene expression • Deficiency: impotence, night blindness, retardation of
growth, xerophthalmia • Signs & Symptoms: Dryness of cornea
Retinoic acid (Vitamin A)Retinoic acid (Vitamin A)
• Source: Liver, kidney, cream, butter, and egg yolk. Yellow and dark green vegetables are good source of the carotenes ( precursor of vitamin A )
• RDA: 800 – 1000 RE (retinol equivalents)
1 RE = 1 mg of retinol or
= 6 mg of β carotene
Cholecalciferol - Vitamin DCholecalciferol - Vitamin D
• Other Names: Ergocalciferol, cholecalciferol• Active form: 1,25-Dihydroxy-cholecalciferol• Function: Calcium uptake• Deficiency: Rickets in children Osteomalacia in adults
Sign and symptom: Soft, pliable bones
Cholecalciferol - Vitamin Cholecalciferol - Vitamin DD
• Source: Fatty fish, liver egg yolk, milk
• RDA: 5 mg cholecalciferol OR 200 IU of vitamin D
αα Tocopherol - Vitamin E Tocopherol - Vitamin E• Active form: several derivatives of tocopherols • Function: Antioxidant• Deficiency: Rare
• Sign and symptom: red cell fragility leads to hemolytic anemia
• Source: Vegetable oils,(good source) liver, eggs
• RDA: 8 – 10 mg/day
Phylloquinone –Vitamin KPhylloquinone –Vitamin K• Active forms: Menadione, menaquinone, &
phylloquinone• Function: γ-Carboxylation of glutamate residue in clotting
and other proteins
• Deficiency: Rare in adults
• Sign and symptom: bleeding in children
• Source: Cabbage, cauliflower, spinch, egg yolk and liver• RDA: 70 – 140 mg/day
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