FAT SOLUBLE FAT SOLUBLE VITAMINS VITAMINS Dr Ayyub Patel, PhD CChem MRSC FRSC Assistant Professor, Medicine KKU KSA
FAT SOLUBLE FAT SOLUBLE VITAMINSVITAMINS
Dr Ayyub Patel, PhD CChem MRSC FRSC
Assistant Professor, Medicine KKU KSA
Lipid (FAT) solubleLipid (FAT) soluble Vitamins Vitamins
Retinoic acid -Vitamin ARetinoic acid -Vitamin A
Retinoic acid (Vitamin A)Retinoic acid (Vitamin A)• Active forms: Retinol, Retinal & Retinoic acid • Functions: Maintenance of reproduction Vision Promotion of growth Differentiation & maintenance of epithelial tissues Gene expression • Deficiency: impotence, night blindness, retardation of
growth, xerophthalmia • Signs & Symptoms: Dryness of cornea
Retinoic acid (Vitamin A)Retinoic acid (Vitamin A)
• Source: Liver, kidney, cream, butter, and egg yolk. Yellow and dark green vegetables are good source of the carotenes ( precursor of vitamin A )
• RDA: 800 – 1000 RE (retinol equivalents)
1 RE = 1 mg of retinol or
= 6 mg of β carotene
Cholecalciferol - Vitamin DCholecalciferol - Vitamin D
• Other Names: Ergocalciferol, cholecalciferol• Active form: 1,25-Dihydroxy-cholecalciferol• Function: Calcium uptake• Deficiency: Rickets in children Osteomalacia in adults
Sign and symptom: Soft, pliable bones
Cholecalciferol - Vitamin Cholecalciferol - Vitamin DD
• Source: Fatty fish, liver egg yolk, milk
• RDA: 5 mg cholecalciferol OR 200 IU of vitamin D
αα Tocopherol - Vitamin E Tocopherol - Vitamin E• Active form: several derivatives of tocopherols • Function: Antioxidant• Deficiency: Rare
• Sign and symptom: red cell fragility leads to hemolytic anemia
• Source: Vegetable oils,(good source) liver, eggs
• RDA: 8 – 10 mg/day
Phylloquinone –Vitamin KPhylloquinone –Vitamin K• Active forms: Menadione, menaquinone, &
phylloquinone• Function: γ-Carboxylation of glutamate residue in clotting
and other proteins
• Deficiency: Rare in adults
• Sign and symptom: bleeding in children
• Source: Cabbage, cauliflower, spinch, egg yolk and liver• RDA: 70 – 140 mg/day