Syphilis 制作人: 陈永 冯斌 时迎斌 张伟强 孙景福 陈娜 徐平 周强 于晓宁 叶茜 主讲人:叶茜.
Post on 28-Dec-2015
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Syphilis There are more than 7
0,000 new cases of syphilis (梅毒) each year .
Syphilis, chronic and slowly progressive, is the third most common sexually transmitted disease.
SpirochetesSpirochetes Gram negative bacteria
long, thin, helical and motile Axial filaments - (a form of flagella) -
are the locomotory organelles
• found between the peptidoglycan layer and outer membrane and running parallel to them
TransmissionTransmission
T. pallidum is generally transmitted by genital/genital contact.
Transmission in utero or during birth can also occur.
It can also be transmitted through blood transfusion.
Primary syphilis
After initial infection hard chancre present.
Mainly seen in outer genital organ.
Last for 4 to 8 weeks.
Secondary syphilis
The organisms has penetrate and systemically spread during this time period.
The patient has flu-like symptoms with secondary lesion particularly affecting the skin(2-10 weeks later)
Mainly in trunk and limbs.
Common features of primary and secondary syphilis
In these two stages large numbers of T. Pallidum often present.
Strong infection , weak damage.
Self-limited
Tertiary syphilis The final stage is tertiary syphilis ( after
several years later). As the disease progresses immunity co
ntrols the bacterial replication and few organisms are seen.
Main manifestation are chronic granuloma and tissue necrosis.
Diagnosis(1) The organisms are often present in
sufficient numbers in exudates detected by dark field microscopy.
The actively motile organisms appears brightly lit against the dark backdrop.
The FTA-ABS (荧光密螺旋体抗体吸收试验 ) is often used.
Diagnosis(2)Diagnosis(2)
3.VDRL and RPR are also widely used.
1. Serological methods are usually used to detect syphilis.
2. Screening methods are based on detecting serum antibodies to cardiolipin in patients (including VDRL test).
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