SCIENTIFIC RESULTS OF TRANS2CARE PROJECT - Lovro Ziberna
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SCIENTIFIC RESULTS OF
TRANS2CARE PROJECT
Lovro Žiberna, PhD MPharm
LP – University of Trieste
Trieste, September 11, 2014
Final conference
1. cell biology, membrane transport
2. statistics, chemometrics
3. transcriptome analysis
4. analytical chemistry
5. genetics, clinical markers
6. IP management
7. clinical chemistry in intensive care
8. electrochemistry
9. anti-microbial peptides
10. IHC, clinical specimens
11. antibody production, stem cells
12. biocompatible materials
13. genetics, clinical markers
THE SCIENCE OF OUR Partners
can we link
local
Institutions by
research
synergies?
CLINICIANSBASIC
SCIENTISTSTECHNO-LOGISTS
Unmet medical needsScientific understanding and possible solutions Technical solutions
TRANS2CARE at start
1. CARDIOVASCULAR DISEASES2. NEURODEGENERATIVE
DISEASES3. CANCER4. OBESITY5. ORTHOPAEDIC DISEASES6. AUTOIMMUNE DISEASES
1. Nephrotoxicity following coronarystent
2. Prion diseases3. Nutrigenomics of obesity4. R&D on implants lifespan5. Bio-availability and bioactivity of
dietary polyphenols6. Coeliac disease
1. Computational and statistical support
2. Analytical chemistry3. Research antibodies4. Nanoparticles, biosensors5. Tech transfer, IP protection
PP2
priondiseases
PP10
diagnosticmAbs
PP6nefrotoxicity
post-coronarydilation
PP6, PP12
plasma free bilirubin
LP
membrane transport
PP9anti-
transglutaminaseantibodies in plasma
PP4
Klothoprotein in
plasma PP7Electro-chemical
biosensors
PP3
Analyticalchemistry
br
NGAL
cytotox
br
Ab
Klo
Ab-BTL
Ab-prion
PP1chemometrics
BTL
prion
PP5training
tech transferIP
PP8
BTL in plantanti-microb.
peptides PP11
biomaterialsfor implants
AMP
Ab-BTL
IDEAS PRODUCTS
technical tools
pre-clinical studies
clinical applications
0
2
4
6
8
10
12
14
LP PP1 PP2 PP3 PP4 PP5 PP6 PP7 PP8 PP9 PP10 PP11 PP12
nu
mb
er
of
pu
blic
atio
ns
scientific papers/bookchapters
active contributions atthe scientificconference
papers in preparation
SCIENTIFIC OUTPUT OF T2C RESEARCHERS
2.38 scientific papers/researcher
3.77 active conference contributions/ researcher
>1 T2C partner (networking):
20.7 % of all scientific papers
37.8 % of all conference contributions
0
5
10
15
20
25
30
scientific papers/book chapters
active contributions at the scientificconference
1
>1
620
23
29
SCIENTIFIC OUTPUT OF T2C RESEARCHERS
pre-disease screening
21st century medicine
focused on identifying the window of opportunity before the full development of pathology (REVERSIBLE CHANGES)
healthy aging
disease diagnosis and causative treatment
20th century medicine
focused on diagnostics (after pathology fully developed) and treatment: pharmacology and/or surgery
chronic treatment to keep body close to homeostasis (IRREVERSIBLE CHANGES)
alleviation of symptoms
pre-historic – 19th century medicine
focused on reducing the pain or other symptoms
NO CAUSATIVE THERAPY
PALLIATIVE THERAPY
cardiovascular
diseases
genotype
diet
physical activity
mental activity
psycho-social activity
biomarkers
no clinical signsbiomarkers
clinical signs biomarkers
clinical signs
deathASYMPTOMATIC ≠ HEALTHY
overweight/ob
esity,
dyslipidemia,
mild
hypertension
acute myocardial
infarction,
arrhythmia,
hypertension
heart failure
(NYHA I-IV),
cardiac death
BIRTH DISEASE DEATH
OBESITY AND OVERWEIGHT
► how specific dietary compounds intake modulates the
gene expression of the adipokines (nutrigenomics)
► interaction between specific dietary compound
and certain genetic polymorphisms by using
Kohonen neural network (nutrigenomics and
personalized medicine) new knowledge on food
and gene interactions to design better diet protocols
ANA PETELIN
ANA PETELIN KATJA VENKO
OBESITY AND OVERWEIGHT
► Identification of early biomarkers of metabolic
imbalance in healthy subjects
► bilirubin as a pre-disease biomarker in
asymptomatic individuals
ANA PETELIN LOVRO ŽIBERNA
CANCER AND LIFESTYLES
“local adjuvant therapy” by anthocyanins-enriched diet
for colon cancer patients
focus on membrane transporters involved in uptake
(bilitranslocase) and efflux (multridrug resistance
proteins) in GIT
JOVANA ČVOROVIĆ
UROŠ RAJČEVIĆ morphological and proteomic characterization of
organotypic spheroids derived from colorectal
cancer tissue
CANCER AND LIFESTYLES
new histological biomarker (expression of
bilitranslocase) for the diagnosis of kidney
cancer
development of anti-bilitranslocase monoclonal
antibodies (diagnostic tool)
UROŠ RAJČEVIĆ LUIGINA DE LEO
NEURODEGENERATION
large-scale transcriptional profiling of brains
from prion-infected macaques, which are an
excellent model for human prion disorders
identification of potential disease biomarkers
and novel potential targets for therapeutics
MAURA BARBISIN KATJA VENKO
novel predictive computational model
(artificial neural network model) for
designing new compounds with anti-
prion activity that can be further
experimentally tested using cell-screening
assay pre-clinical studies
CARDIOVASCULAR DISEASES
interventional cardiology iodine contrast-induced
nephropathy
detection of early signs of nephropathy by
serum biomarker NGAL
POLONA LIKAR MITJA MARTELANC
POLONA LIKAR LOVRO ŽIBERNA
pharmacological and nutraceutical modulations of
contrast-induced toxicity on human vascular
endothelial cells
COELIAC DISEASE
double immunofluorescence analysis allowed the
early diagnosis in subjects at high risk of celiac
disease
pre-disease diagnosis (early diet modification leads
to better prognosis)
LUIGINA DE LEO
LUIGINA DE LEO MORENA SILVESTRINI
development of electrochemical
biosensors for the detection of different
autoantibodies (e.g., anti-tTG), anti-
gliadin, anti-thyroid peroxidase (anti-TPO)
involved in celiac disease and associated
autoimmune diseases, directly in biological
samples
new technology: electrochemical
impedance spectroscopy
BONE HEALTH
improving life-span of orthopedic implants by the
prevention of prosthetic joint infections
incorporation/immobilization of antimicrobial
peptides (AMPs) into biopolymeric matrices as
potential coatings for orthopedic implants.
FRANJA ŠULEK FRANCESCA D’ESTE
ALESSANDRO BALDAN correlation between blood biomarker Klotho
factor and bone mineral density
lower Klotho levels in peripheral blood are linked to
osteopenia and osteoporosis in the femur
DIAGNOSTIC BIOMARKERS
novel method for the detection of free bilirubin in
human serum (non-routine clinical measurement of
the bioactive form) – around 10 nM in human serum
MITJA MARTELANC
fast, cheap and easy-to use sensing
devices for the detection of molecules of
clinical importance, directly in biological
samples
improved method for total and
conjugated bilirubin detection in serum
samples using a novel biosensor based
on electrochemical detection
LOVRO ŽIBERNA
MORENA SILVESTRINI
INTELLECTUAL PROPERTY
open innovation
“Think before you publish.” “Perhaps, patent?”
creation of a necessary scientific bridge between
a number of entities:
- Universities; - Big industries;
- Research centres; - Tech transfer offices;
- The market; - Public institutions;
- SMEs; - Laboratories
• good connection improves the outputs of scientific
research
GIORGIA FAVARO
IP
BRIDGE
Academics
Big industries
ResearchCentres
TechTransfer Offices
Market
Public Insitution
s
SMEs
Laboratories
Trans2Care workpackagesEmbedding training in the network’s activities
WP6TECH
TRANSFER
WP2PREPARATORY
ACTIVITY
WP7SUSTAINABILITY
WP8DISSEMINATION
WP5MAPPING &
ROAD-MAPPING
COORDINATION
WP1MANAGEMENT
WP4part 1
TECHNOLOGICAL TRAINING
WP3RECRUITMENT
OF 14 RESEARCHERS
WP4 part 2
COMPLEMENTARYTRAINING
EVOLUTION OF HUMAN CAPITAL
The 14 researchers have done
large parts of WP 6-8
8 WPs
WP 6 as the core
WP 5,7,8ancillary to WP6
Training: WP4 and transversal to WPs
scientific research = technological training
SCIENTIFIC COMMUNICATION
OTHER SCIENTIFIC ACTIVITIESFocus on knowledge sharing and developing integrated skills
• acting as reviewers of original research manuscripts for SCI
scientific journals
• tutoring and co-mentorships of PhD and undergraduate students
• submission of post-doctoral grant applications
• active involvement in research discussion at online scientific
forums
• participation at online scientific webinars
Progetto Rete Transregionale per l’ innovazione ed il Trasferimento Tecnologico per ilMiglioramento della Sanità finanziato nell’ambito del Programma per la CooperazioneTransfrontaliera Italia-Slovenia 2007-2013, dal Fondo europeo di sviluppo regionale e dai fondinazionali.Projekt Transregionalno omrežje za inovacijo in prenos tehnološkega znanja za izboljšanjezdravstva sofinancirana v okviru Programa čezmejnega sodelovanja Slovenija-Italija 2007-2013
iz sredstev Evropskega sklada za regionalni razvoj in nacionalnih sredstev.
Thank you for the attention !
Partners: LP – Università degli Studi di Trieste, PP1 – Kemijski Inštitut Ljubljana, PP1 – Kemijski Inštitut Ljubljana, PP2 – ScuolaInternazionale Superiore di Studi Avanzati, PP3 – Univerza v Novi Gorici, PP4 – Università di Ferrara, PP5 – Treviso Tecnologia, PP6 –Splošna Bolnišnica Dr. Franca Derganca, PP7 – Università Ca’ Foscari di Venezia, PP8 – Università di Udine, PP9 – IRCCS Burlo Garofalo,PP10 – Zavod Republike Slovenije Za Transfuzijsko Medicino, PP11 – Ortopedska Bolnišnica Valdoltra, PP12 – Univerza na Primorskem -Fakulteta za Vede o Zdravju.
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