Pathology MCQ

Pathology MCQ

PHASE 1

1.Which of the following appear in the red cells of Ivemark syndrome/asplenic individuals?

a. Macroovalocytosis b.Basophilic stipplingc. Howell-Jolly bodiesd.Target cells

2. The life span of platelets in circulation is about?

a. 1 to 3 days b.3 to 5 days c. 5 to 7 days d. 7 to 10 days

3. A 13 yr old child suffered from dysentery one week ago, currently complaining of hematuria and raised serum creatinine. PBS examination is expected to show:

a. Target cellb.Spherocyte c. Schistocyte d.Bite cell

4. HbC is best illustrated as?

a. Α2ß2 3Glu→Lys

b. Α2ß2 4Glu→Lys

c. Α2ß2 5Glu→Lys

d. Α2ß2 6Glu→Lys

5. The 4T ‘s scoring system for pre-test probability of HIT includes all except:

a. Thrombocytopenia b. Timing of platelet count fallc. Thrombosisd. Treatment dose

6.In comparison to myeloma,which is more frequent in plasma cell leukemia:

a. Osteolytic lesionb.Bone painc. Renal failured.All of the above

7. Leukaemia with t(15;17)(q22;q12) usually has the immunophenotype:

a. CD13,CD33,CD15,CD117b.CD13,CD33,CD117,HLADRc. CD13,CD33,CD117,cMPOd.CD13,CD33,CD15,cMPO

8. Match the following with respect to iron deficiency

anaemia:

a. Red cell zinc protoporphyrin (ZPP)

b. Serum transferrin receptor

c. Transferrin saturationd. Hepcidin

1. Increases

2. Decreases

3. Increases 4. Decreases

9. Which of the following is safe in therapeutic doses in patients with G6PD deficiency:

a. Primaquineb.Acetaminophenc. Sulfamethoxazoled.Dapsone

10. The affinity of haemoglobin for Oxygen is decreased by all except:

a. Fever b.Alkalosisc. Binding of CO2d.Binding of 2,3-DPG

11. An Increased percentage of HbA2 is expected in :

a. αthal traitb. ßthal traitc. δßthal traitd. All of the above

12. A 15 yr old child presents with fever and generalised petechiae, lab investigation reveal:

• Hb 6gm% MCV = 105fl MCH = 30pg • WBC = 1.2 X 109 /L PC = 10 X 109 /L • LYMP%- 73%, GRAN%-25%,MID%-2%• BM: Hypo cellular. What is the most likely diagnosis?a. Severe aplastic anemiab. Very severe aplastic anemiac. Nonsevere aplastic anemiad. Hypoplastic MDS

13. All are direct thrombin inhibitors except:a. Fondaparinux sodiumb.Bivalirudinc. Argatroband.Lepirudin

14. For the given coagulation work up results which is the most probable diagnosis:

• BT- 5 min• PT- 11 sec ( 10 sec)• APTT- 50sec (32 sec)• Mixing study with factor IX deficient plasma: APTT – 40

seca. Hemophilia Ab. Hemophilia Bc. Hemophilia Cd. Factor VIII inhibitor positive

15. Regarding febrile nonhemolytic transfusion reaction false is:

a. More common in multiply transfused patientsb.HLA antibodies are most commonc. Leucodepletion of blood products is not

helpfuld.Due to transfusion of cytokines

16. Which is not a GpIIb/IIIa inhibitor:a. Abciximabb.Eptifibatidec. Tirofiband.Argatroban

17.Haemolytic disease of new born(erythroblastosis fetalis ) is an example of:

a. Type I hypersenstivityb.Type II hypersenstivityc. Type III hypersenstivityd.Type IV hypersenstivity

18. Pre-transfusion cross-match is not required for:

a. Cryoprecipitateb.pRBCc. FFPd.Granulocyte tranfusion

19. Neutrophilia is seen in all except:a. Leucocyte adhesion defectb.Steroid administrationc. Lithium therapyd.Kostmann syndrome

20. Infectious complications of blood transfusion may result from all except:

a. HTLV Ib.HTLV IIc. West Nile virus d.None of the above

21. Good prognosis ALL:a. t(4;11)b.t(9;22)c. t(12;21)d.t(1;19)

22. For diagnosis of Smoldering Myeloma, false is:

a. BM plasma cells ≤ 10%b.Absence of anemiac. Serum monoclonal protein ≥ 3g/dld.None of the above

23. IPSS for MDS includes all except:a. Marrow blast %b.Karyotype c. Cytopeniasd.Age

24. Hairy cell leukaemia , immunophenotype:a. Bright CD20,CD10,CD25,CD103b.Dim CD20,CD10,CD25,CD103c. Bright CD20,CD11c,CD25,CD103d.Dim CD20,CD11c,CD25,CD103

25. WHO definition of anaemia in pregnancy requires Hb below:

a. 10g%b.11g%c. 12g%d.13g%

26. Albino child with repeated infection

most probable diagnosis:a. Grescilli syndromeb. Chediac Higashi syndromec. Dohle bodiesd. Toxic granules

27.

Comment on PBS:

28.

Identify the cell with arrow head:a.Gaucher cellb.Mott cellc.Histoplasma inclusion d.Fungal bodies

29.

Identify the abnormality in the Karyotype

30.Identify the cytogenetic finding shown in the FISH metaphase spread.