Organs for research and education Matthew Bock. When are organs used for research? Only after they have been determined unsuitable for transplant.

Organs for researchOrgans for researchand educationand education

Matthew BockMatthew Bock

When are organs usedWhen are organs usedfor research?for research?

Only after they have been determined unsuitable Only after they have been determined unsuitable for transplantfor transplant

What makes an organ unsuitable for What makes an organ unsuitable for transplant?transplant?

PerformancePerformance ConditionCondition

PerformancePerformance

KidneysKidneysCreatinineCreatinine

LiverLiverAST/ALTAST/ALT

PancreasPancreasA1CA1C

HeartHeart Troponin, EchoTroponin, Echo

Lungs

X-ray, PO2

ConditionCondition

Fatty pancreasFatty pancreas Polycystic kidneyPolycystic kidney Fibrotic or fatty liverFibrotic or fatty liver

If we can’t transplant…If we can’t transplant…

There is still an option…There is still an option…

Research consentResearch consent

Page 2 (back) of consent formPage 2 (back) of consent form

Page 2 (back) of consent formPage 2 (back) of consent form

Research consent for transplanted Research consent for transplanted organsorgans

Liver studyLiver study BiopsyBiopsy

Lung studyLung study Bronch washings and blood ampleBronch washings and blood ample

Kidney studyKidney study

OrderOrder

11stst - Transplant - Transplant 22ndnd- In-house research- In-house research 33rdrd - National - National

OrderOrder

11stst - Transplant - Transplant 22ndnd- In-house research- In-house research 33rdrd - National - National

OrderOrder

11stst - Transplant - Transplant 22ndnd- In-house research- In-house research

Pancreas islet cellsPancreas islet cells 33rdrd - National - National

OrderOrder

11stst - Transplant - Transplant 22ndnd- In-house research- In-house research 33rdrd - National - National

OrderOrder

11stst - Transplant - Transplant 22ndnd- In-house research- In-house research 33rdrd - National - National

NDRINDRI IIAMIIAM

Who are NDRI and IIAM?Who are NDRI and IIAM?

NDRINDRI, National disease research interchange, National disease research interchange IIAMIIAM, International Institute for the , International Institute for the

Advancement of MedicineAdvancement of Medicine

Both are 501c non-profitBoth are 501c non-profit

HeartHeart

Heart, Arteries and VeinsHeart, Arteries and VeinsMedical investigators use the human heart Medical investigators use the human heart

to learn about the development of to learn about the development of atherosclerosis in coronary arteriesatherosclerosis in coronary arteries

KidneysKidneys

Renal tissues is used to study the toxicity of Renal tissues is used to study the toxicity of anti-cancer therapies and to study the safe anti-cancer therapies and to study the safe concentrations of other drugs in development concentrations of other drugs in development

LungsLungs

Research into chronic obstructive pulmonary Research into chronic obstructive pulmonary disease (COPD), cystic fibrosis, asthma, disease (COPD), cystic fibrosis, asthma, emphysema and allergies emphysema and allergies

PancresPancres

Diabetes researchers rely on pancreatic tissues Diabetes researchers rely on pancreatic tissues to explore the regulation of insulin production, to explore the regulation of insulin production, to identify the genetic components of the to identify the genetic components of the disease and for toxicity studies on new disease and for toxicity studies on new compounds. compounds.

LiverLiver

Hepatocyte cell isolation for transplantationHepatocyte cell isolation for transplantation Human model for drug interaction, toxicity Human model for drug interaction, toxicity

and metabolism testingand metabolism testing

EducationEducation

Whole body donationWhole body donation