Organs for Organs for research research and education and education Matthew Bock Matthew Bock
Dec 24, 2015
When are organs usedWhen are organs usedfor research?for research?
Only after they have been determined unsuitable Only after they have been determined unsuitable for transplantfor transplant
What makes an organ unsuitable for What makes an organ unsuitable for transplant?transplant?
PerformancePerformance ConditionCondition
PerformancePerformance
KidneysKidneysCreatinineCreatinine
LiverLiverAST/ALTAST/ALT
PancreasPancreasA1CA1C
HeartHeart Troponin, EchoTroponin, Echo
Lungs
X-ray, PO2
ConditionCondition
Fatty pancreasFatty pancreas Polycystic kidneyPolycystic kidney Fibrotic or fatty liverFibrotic or fatty liver
If we can’t transplant…If we can’t transplant…
There is still an option…There is still an option…
Research consentResearch consent
Research consent for transplanted Research consent for transplanted organsorgans
Liver studyLiver study BiopsyBiopsy
Lung studyLung study Bronch washings and blood ampleBronch washings and blood ample
Kidney studyKidney study
OrderOrder
11stst - Transplant - Transplant 22ndnd- In-house research- In-house research 33rdrd - National - National
OrderOrder
11stst - Transplant - Transplant 22ndnd- In-house research- In-house research 33rdrd - National - National
OrderOrder
11stst - Transplant - Transplant 22ndnd- In-house research- In-house research
Pancreas islet cellsPancreas islet cells 33rdrd - National - National
OrderOrder
11stst - Transplant - Transplant 22ndnd- In-house research- In-house research 33rdrd - National - National
OrderOrder
11stst - Transplant - Transplant 22ndnd- In-house research- In-house research 33rdrd - National - National
NDRINDRI IIAMIIAM
Who are NDRI and IIAM?Who are NDRI and IIAM?
NDRINDRI, National disease research interchange, National disease research interchange IIAMIIAM, International Institute for the , International Institute for the
Advancement of MedicineAdvancement of Medicine
Both are 501c non-profitBoth are 501c non-profit
HeartHeart
Heart, Arteries and VeinsHeart, Arteries and VeinsMedical investigators use the human heart Medical investigators use the human heart
to learn about the development of to learn about the development of atherosclerosis in coronary arteriesatherosclerosis in coronary arteries
KidneysKidneys
Renal tissues is used to study the toxicity of Renal tissues is used to study the toxicity of anti-cancer therapies and to study the safe anti-cancer therapies and to study the safe concentrations of other drugs in development concentrations of other drugs in development
LungsLungs
Research into chronic obstructive pulmonary Research into chronic obstructive pulmonary disease (COPD), cystic fibrosis, asthma, disease (COPD), cystic fibrosis, asthma, emphysema and allergies emphysema and allergies
PancresPancres
Diabetes researchers rely on pancreatic tissues Diabetes researchers rely on pancreatic tissues to explore the regulation of insulin production, to explore the regulation of insulin production, to identify the genetic components of the to identify the genetic components of the disease and for toxicity studies on new disease and for toxicity studies on new compounds. compounds.
LiverLiver
Hepatocyte cell isolation for transplantationHepatocyte cell isolation for transplantation Human model for drug interaction, toxicity Human model for drug interaction, toxicity
and metabolism testingand metabolism testing