Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM)

Xinyu Zhang, Sandilya V.B. Garimella, Spencer A. Prost, Ian K. Webb, Randolph V. Norheim, Brian L. LaMarche, Tsung-Chi Chen, Aleksey V. Tolmachev,

Gordon A. Anderson, Yehia M. Ibrahim and Richard D. Smith

Pacific Northwest National Laboratory

Basic Gas Phase Ion Manipulations

Ion transport

Ion trapping

Ion-ion/ion-molecule reactions

Ion mobility separations (IMS)

Ion Trapping in SLIM Explored at ~Torr Pressures

Ion accumulation and charge capacity in a SLIM trap

Ion release from a SLIM trap

Ion storage for extended times to e.g. enable more efficient use of MS

Structures for Lossless Ion Manipulation

See Poster WP714 by Ian Webb et al., Jun 17

5 mm

Slim Electrode Designs Used in This Study

5.6 mm

0.76 mm

0.76 mm

0.76 mm

Rung electrodes

Guard electrodes

Guard electrodes

DC Rung gradient

Guard gradient

+ - + - + - + - + - + -

Comparable DC Voltages Used on Rung and Guard Electrodes to Facilitate Ion Confinement

Guard gradient

DC for ion confinement and manipulation used in conjunction with RF confinement potentials applied to rung electrodes

10.00 40.00 70.00

0 25 50 75

Potential (V)0

25

50

Pot

entia

l (V)

Pseudo Potential Well (Ion Confinement)

X

Y

Charge: 1+Mass: 1000RF: 200 Vp-p at 800 kHzGuard Bias: +5 V

See Poster WP716 by Sandilya Garimella et al., Jun 17

7.000 53.50 100.0

0 20 40 60

Potential (V)

Pot

entia

l (V)

01020

Z

Y

Pseudo Potential Well (Ion Transport)

See Poster WP716 by Sandilya Garimella et al., Jun 17

DC: 12 V/cm

6

10.00 55.00 100.0

0 50

Potential (V)

Pot

entia

l (V)

15

20

Z

Y

Pseudo Potential Well (Ion Trapping)

See Poster WP716 by Sandilya Garimella et al., Jun 17

DC: 12 V/cm

Instrumental Arrangement Used

Pressure: 4.3 torr (Nitrogen)RF: 165 Vp-p, 1.7 MHz

Continuous Mode (DC Gradient Arrangement)

40 V

Fill

30 cm

Sample Tetraoctylammonium Bromide1μM in CH3CN/H2O/CH3COOH (75/24/1)

m/z: 466.3

Continuous Mode (Current Measurements)

0 100 200 300 4000

10

20

30

continuous mode

Cur

rent

(pA

)

Arrival Time (ms)

SLIM Used for the Charge Capacity Study

Entrance Gate Exit GateTrapping Region

Charge Capacity (DC Gradient Arrangement)

40 V

15 V

Fill(Time varies)

Release

7.5 cm 7.5 cm15 cm

Charge Capacity (Current Measurements)

0 100 200 300 4000

10

20

30

continuous mode

320 ms (filling time)

Cur

rent

(pA

)

Arrival Time (ms)

0 100 200 300 4000

10

20

30

continuous mode

320 ms (filling time)

Cur

rent

(pA

)

Arrival Time (ms)

Charge Capacity Measurements

0 100 200 300 4000

10

20

30

continuous mode

320 ms (filling time)

Cur

rent

(pA

)

Arrival Time (ms)

Charge Capacity Measurements

SLIM Charge Capacity

0 500 1000 1500 2000 2500

0

10M

20M

30M

40M

50M

60M

70M Number of Charges

Num

ber o

f Cha

rges

Filling Time (ms)

0.0

0.2

0.4

0.6

0.8

1.0

Trapping Effeciency Trapping Effeciency

Exit GateEntrance Gate

Trapping Region

SLIM Used for the Release Time Study

30 V/cm

7 cm0.46 cm

Accumulate

0.7 V/cm

14.5 V/cm

10 V/cm

Fill(80 ms)

Release(Released Ion # v.s. Release Time) 5 M charges

Release Time (DC Gradient Arrangement)

m/z: 466.3

SLIM Release Time

0.0 0.5 1.0 1.50

50

100

150

200

250Io

n C

ount

(A.U

.)

Release Time (ms)

1 ms

37 38 39 40 41 42 430

20

40

60

Ion

Cou

nt (A

.U.)

Mobility Time (ms)

SLIM Used for the Storage Time Study

Entrance Gate Exit GateTrapping Region

40 V

15 V

15 V

Fill(5 ms)

Trap(Time varies)

Release

7.5 cm 7.5 cm15 cm

Storage Time (DC Gradient Arrangement)

m/z: 466.3 and 690.5

0.0

0.2

0.4

0.6

0.8

1.0

1.2

m/z 466.3, (C8H17)4N+

m/z 690.5, (C12H25)4N+Nor

mal

ized

Inte

nsity

Trapping Time0 10 s 20 s 30 s 5 hr

SLIM Storage Time

0.0

0.2

0.4

0.6

0.8

1.0

1.2

m/z 466.3, (C8H17)4N+

m/z 690.5, (C12H25)4N+Nor

mal

ized

Inte

nsity

Trapping Time0 10 s 20 s 30 s 5 hr

SLIM Storage Time

0.0

0.2

0.4

0.6

0.8

1.0

1.2

m/z 466.3, (C8H17)4N+

m/z 690.5, (C12H25)4N+Nor

mal

ized

Inte

nsity

Trapping Time0 10 s 20 s 30 s 5 hr

SLIM Storage Time

0.0

0.2

0.4

0.6

0.8

1.0

1.2

m/z 466.3, (C8H17)4N+

m/z 690.5, (C12H25)4N+Nor

mal

ized

Inte

nsity

Trapping Time0 10 s 20 s 30 s 5 hr

SLIM Storage Time

400 500 600 700 8000

1000

2000

3000

4000

Abu

ndan

ce (A

.U.)

m/Z400 500 600 700 800

0

1000

2000

3000

4000

Abu

ndan

ce (A

.U.)

m/Z

Trapping for 1 s Trapping for 5 hours

SLIM Storage Time

Conclusions

Effective pseudo potential wells in SLIM

The construction and application of a number of SLIM arrangements

Defined charge capacity of a SLIM trap

Ion release from a SLIM trap

Lossless ion trapping at Torr for hours in SLIM

Initial research has demonstrated:

Acknowledgements

NIH National Institute of General Medical Sciences Biomedical Technology Research Resource

DOE Office of Biological and Environmental Research

PNNL Laboratory Directed R&D