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Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang , Sandilya V.B. Garimella, Spencer A. Prost, Ian K. Webb, Randolph V. Norheim, Brian L. LaMarche, Tsung-Chi Chen, Aleksey V. Tolmachev, Gordon A. Anderson, Yehia M. Ibrahim and Richard D. Smith Pacific Northwest National Laboratory
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Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

Apr 08, 2020

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Page 1: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM)

Xinyu Zhang, Sandilya V.B. Garimella, Spencer A. Prost, Ian K. Webb, Randolph V. Norheim, Brian L. LaMarche, Tsung-Chi Chen, Aleksey V. Tolmachev,

Gordon A. Anderson, Yehia M. Ibrahim and Richard D. Smith

Pacific Northwest National Laboratory

Page 2: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

Basic Gas Phase Ion Manipulations

Ion transport

Ion trapping

Ion-ion/ion-molecule reactions

Ion mobility separations (IMS)

Page 3: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

Ion Trapping in SLIM Explored at ~Torr Pressures

Ion accumulation and charge capacity in a SLIM trap

Ion release from a SLIM trap

Ion storage for extended times to e.g. enable more efficient use of MS

Page 4: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

Structures for Lossless Ion Manipulation

See Poster WP714 by Ian Webb et al., Jun 17

5 mm

Page 5: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

Slim Electrode Designs Used in This Study

5.6 mm

0.76 mm

0.76 mm

0.76 mm

Rung electrodes

Guard electrodes

Guard electrodes

Page 6: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

DC Rung gradient

Guard gradient

+ - + - + - + - + - + -

Comparable DC Voltages Used on Rung and Guard Electrodes to Facilitate Ion Confinement

Guard gradient

DC for ion confinement and manipulation used in conjunction with RF confinement potentials applied to rung electrodes

Page 7: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

10.00 40.00 70.00

0 25 50 75

Potential (V)0

25

50

Pot

entia

l (V)

Pseudo Potential Well (Ion Confinement)

X

Y

Charge: 1+Mass: 1000RF: 200 Vp-p at 800 kHzGuard Bias: +5 V

See Poster WP716 by Sandilya Garimella et al., Jun 17

Page 8: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

7.000 53.50 100.0

0 20 40 60

Potential (V)

Pot

entia

l (V)

01020

Z

Y

Pseudo Potential Well (Ion Transport)

See Poster WP716 by Sandilya Garimella et al., Jun 17

DC: 12 V/cm

Page 9: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

6

10.00 55.00 100.0

0 50

Potential (V)

Pot

entia

l (V)

15

20

Z

Y

Pseudo Potential Well (Ion Trapping)

See Poster WP716 by Sandilya Garimella et al., Jun 17

DC: 12 V/cm

Page 10: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

Instrumental Arrangement Used

Pressure: 4.3 torr (Nitrogen)RF: 165 Vp-p, 1.7 MHz

Page 11: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

Continuous Mode (DC Gradient Arrangement)

40 V

Fill

30 cm

Sample Tetraoctylammonium Bromide1μM in CH3CN/H2O/CH3COOH (75/24/1)

m/z: 466.3

Page 12: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

Continuous Mode (Current Measurements)

0 100 200 300 4000

10

20

30

continuous mode

Cur

rent

(pA

)

Arrival Time (ms)

Page 13: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

SLIM Used for the Charge Capacity Study

Entrance Gate Exit GateTrapping Region

Page 14: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

Charge Capacity (DC Gradient Arrangement)

40 V

15 V

Fill(Time varies)

Release

7.5 cm 7.5 cm15 cm

Page 15: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

Charge Capacity (Current Measurements)

0 100 200 300 4000

10

20

30

continuous mode

320 ms (filling time)

Cur

rent

(pA

)

Arrival Time (ms)

Page 16: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

0 100 200 300 4000

10

20

30

continuous mode

320 ms (filling time)

Cur

rent

(pA

)

Arrival Time (ms)

Charge Capacity Measurements

Page 17: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

0 100 200 300 4000

10

20

30

continuous mode

320 ms (filling time)

Cur

rent

(pA

)

Arrival Time (ms)

Charge Capacity Measurements

Page 18: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

SLIM Charge Capacity

0 500 1000 1500 2000 2500

0

10M

20M

30M

40M

50M

60M

70M Number of Charges

Num

ber o

f Cha

rges

Filling Time (ms)

0.0

0.2

0.4

0.6

0.8

1.0

Trapping Effeciency Trapping Effeciency

Page 19: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

Exit GateEntrance Gate

Trapping Region

SLIM Used for the Release Time Study

Page 20: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

30 V/cm

7 cm0.46 cm

Accumulate

0.7 V/cm

14.5 V/cm

10 V/cm

Fill(80 ms)

Release(Released Ion # v.s. Release Time) 5 M charges

Release Time (DC Gradient Arrangement)

m/z: 466.3

Page 21: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

SLIM Release Time

0.0 0.5 1.0 1.50

50

100

150

200

250Io

n C

ount

(A.U

.)

Release Time (ms)

1 ms

37 38 39 40 41 42 430

20

40

60

Ion

Cou

nt (A

.U.)

Mobility Time (ms)

Page 22: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

SLIM Used for the Storage Time Study

Entrance Gate Exit GateTrapping Region

Page 23: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

40 V

15 V

15 V

Fill(5 ms)

Trap(Time varies)

Release

7.5 cm 7.5 cm15 cm

Storage Time (DC Gradient Arrangement)

m/z: 466.3 and 690.5

Page 24: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

0.0

0.2

0.4

0.6

0.8

1.0

1.2

m/z 466.3, (C8H17)4N+

m/z 690.5, (C12H25)4N+Nor

mal

ized

Inte

nsity

Trapping Time0 10 s 20 s 30 s 5 hr

SLIM Storage Time

Page 25: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

0.0

0.2

0.4

0.6

0.8

1.0

1.2

m/z 466.3, (C8H17)4N+

m/z 690.5, (C12H25)4N+Nor

mal

ized

Inte

nsity

Trapping Time0 10 s 20 s 30 s 5 hr

SLIM Storage Time

Page 26: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

0.0

0.2

0.4

0.6

0.8

1.0

1.2

m/z 466.3, (C8H17)4N+

m/z 690.5, (C12H25)4N+Nor

mal

ized

Inte

nsity

Trapping Time0 10 s 20 s 30 s 5 hr

SLIM Storage Time

Page 27: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

0.0

0.2

0.4

0.6

0.8

1.0

1.2

m/z 466.3, (C8H17)4N+

m/z 690.5, (C12H25)4N+Nor

mal

ized

Inte

nsity

Trapping Time0 10 s 20 s 30 s 5 hr

SLIM Storage Time

Page 28: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

400 500 600 700 8000

1000

2000

3000

4000

Abu

ndan

ce (A

.U.)

m/Z400 500 600 700 800

0

1000

2000

3000

4000

Abu

ndan

ce (A

.U.)

m/Z

Trapping for 1 s Trapping for 5 hours

SLIM Storage Time

Page 29: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

Conclusions

Effective pseudo potential wells in SLIM

The construction and application of a number of SLIM arrangements

Defined charge capacity of a SLIM trap

Ion release from a SLIM trap

Lossless ion trapping at Torr for hours in SLIM

Initial research has demonstrated:

Page 30: Lossless Ion Trapping in Structures for Lossless Ion ... · Lossless Ion Trapping in Structures for Lossless Ion Manipulation (SLIM) Xinyu Zhang, Sandilya V.B. Garimella, Spencer

Acknowledgements

NIH National Institute of General Medical Sciences Biomedical Technology Research Resource

DOE Office of Biological and Environmental Research

PNNL Laboratory Directed R&D