Human Ebola Virus Species and Compositions and Methods Thereof
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US 20120251502A1
(19) United States (12) Patent Application Publication (10) Pub. No.: US 2012/0251502 A1
Towner et al. (43) Pub. Date: Oct. 4, 2012
(54) HUMAN EBOLA VIRUS SPECIES AND Publication Classi?cation COMPOSITIONS AND METHODS THEREOF
(51) Int. Cl. (75) Inventors: Jonathan S. ToWner, Atlanta, GA A61K 35/76 (200601)
(US); Stuart T. Nichol, Atlanta, GA C07H 21/04 (200601) (US); James A. Comer, Atlanta, CIZN 7/04 (200601) GA (US); Thomas G. Ksiazek, C07K 14/08 (200601) Atlanta, GA (US); Pierre E. Rollin, A61K 38/02 (2006-01) Atlanta, GA (Us) A61K 31/7088 (2006.01)
C07K 7/06 (2006.01) (73) Assignee: The Government of the US as C07K 7/08 (200601)
Represented by the Secretary of CIZN 7/00 (200601) the Dept. of health, Atlanta, GA C07H 21/02 (200601)
(Us) (52) U.S. Cl. ................ .. 424/93.6; 435/235.1; 536/2372;
(21) App1_ NO; 13/125,390 435/236; 530/350; 514/1.1; 514/44 R; 530/330; 530/329; 530/328; 530/327; 530/326; 530/325;
(22) PCT Filed: Oct. 26, 2009 530/324
(86) PCT No.: PCT/US09/62079 (57) ABSTRACT
§371 (c)(1), Com . . . . positions and methods including and related to the Ebola (2)’ (4) Date: Jun‘ 21’ 2011 Bundibugyo virus (EboBun) are provided. Compositions are
Related U 5 Application Data provided that are operable as immunogens to elicit and ' ' immune response or protection from EboBun challenge in a
(62) Division of application No, 61 /108,175, ?led on Oct subject such as a primate. Inventive methods are directed to 24, 2008. detection and treatment of EboBun infection.
Patent Application Publication Oct. 4, 2012 Sheet 1 0f 27 US 2012/0251502 A1
09 DFIC 1999 1/100
Ravn Kenya 1987
M al'bu F9 _94 Ozolin Zimbabwe 1975
07 BBC 1999
05 DRC 1999
13790 Angola 2005
Popp Uganda/Germany1967
Musoke Kenya 1980
1mm Za|re, Yambuku 1976
& ZaIre, Kikwit1995
1/100 Cote d’lv0ire1994 Ebola 1 T
1/100 |:S|,ldal‘|, Gulu Uganda 2000 0.5 subst/site Heston USA 1989
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