US 20120251502A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2012/0251502 A1 Towner et al. (43) Pub. Date: Oct. 4, 2012 (54) HUMAN EBOLA VIRUS SPECIES AND Publication Classi?cation COMPOSITIONS AND METHODS THEREOF (51) Int. Cl. (75) Inventors: Jonathan S. ToWner, Atlanta, GA A61K 35/76 (200601) (US); Stuart T. Nichol, Atlanta, GA C07H 21/04 (200601) (US); James A. Comer, Atlanta, CIZN 7/04 (200601) GA (US); Thomas G. Ksiazek, C07K 14/08 (200601) Atlanta, GA (US); Pierre E. Rollin, A61K 38/02 (2006-01) Atlanta, GA (Us) A61K 31/7088 (2006.01) C07K 7/06 (2006.01) (73) Assignee: The Government of the US as C07K 7/08 (200601) Represented by the Secretary of CIZN 7/00 (200601) the Dept. of health, Atlanta, GA C07H 21/02 (200601) (Us) (52) U.S. Cl. ................ .. 424/93.6; 435/235.1; 536/2372; (21) App1_ NO; 13/125,390 435/236; 530/350; 514/1.1; 514/44 R; 530/330; 530/329; 530/328; 530/327; 530/326; 530/325; (22) PCT Filed: Oct. 26, 2009 530/324 (86) PCT No.: PCT/US09/62079 (57) ABSTRACT §371 (c)(1), Com . . . . positions and methods including and related to the Ebola (2)’ (4) Date: Jun‘ 21’ 2011 Bundibugyo virus (EboBun) are provided. Compositions are Related U 5 Application Data provided that are operable as immunogens to elicit and ' ' immune response or protection from EboBun challenge in a (62) Division of application No, 61 /108,175, ?led on Oct subject such as a primate. Inventive methods are directed to 24, 2008. detection and treatment of EboBun infection.
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Human Ebola Virus Species and Compositions and Methods Thereof
Compositions and methods including and related to the Ebola Bundibugyo virus (EboBun) are provided. Compositions are provided that are operable as immunogens to elicit and immune response or protection from EboBun challenge in a subject such as a primate. Inventive methods are directed to detection and treatment of EboBun infection.
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US 20120251502A1
(19) United States (12) Patent Application Publication (10) Pub. No.: US 2012/0251502 A1
Towner et al. (43) Pub. Date: Oct. 4, 2012
(54) HUMAN EBOLA VIRUS SPECIES AND Publication Classi?cation COMPOSITIONS AND METHODS THEREOF
(51) Int. Cl. (75) Inventors: Jonathan S. ToWner, Atlanta, GA A61K 35/76 (200601)
(US); Stuart T. Nichol, Atlanta, GA C07H 21/04 (200601) (US); James A. Comer, Atlanta, CIZN 7/04 (200601) GA (US); Thomas G. Ksiazek, C07K 14/08 (200601) Atlanta, GA (US); Pierre E. Rollin, A61K 38/02 (2006-01) Atlanta, GA (Us) A61K 31/7088 (2006.01)
C07K 7/06 (2006.01) (73) Assignee: The Government of the US as C07K 7/08 (200601)
Represented by the Secretary of CIZN 7/00 (200601) the Dept. of health, Atlanta, GA C07H 21/02 (200601)
(Us) (52) U.S. Cl. ................ .. 424/93.6; 435/235.1; 536/2372;
§371 (c)(1), Com . . . . positions and methods including and related to the Ebola (2)’ (4) Date: Jun‘ 21’ 2011 Bundibugyo virus (EboBun) are provided. Compositions are
Related U 5 Application Data provided that are operable as immunogens to elicit and ' ' immune response or protection from EboBun challenge in a
(62) Division of application No, 61 /108,175, ?led on Oct subject such as a primate. Inventive methods are directed to 24, 2008. detection and treatment of EboBun infection.