Fluid and Electrolyte Management of the Surgical Patient Dr Abdollahi Afshar Hospital.

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Fluid and Electrolyte Management of the

Surgical Patient

Dr Abdollahi

Afshar Hospital

Fluid therapy is often poorly taught poorly understood and

poorly done

lsquolsquoFluid therapy should be directed not only to Fluid therapy should be directed not only to effective volume expansion of a leaky effective volume expansion of a leaky circulation but also to micro vascular circulation but also to micro vascular protectionrsquoprotectionrsquo

Fluid and electrolyte management are paramount to the care of the surgical patient Changes in both fluid volume and electrolyte composition occur preoperatively intraoperatively and post operatively as well as in response to trauma and sepsis

Total Body Water

Who is having higher proportion of body weight as water And Why

1048699Males or Females

1048699Lean or Obese

1048699Young or elderly

Body Fluid CompartmentsBody Fluid Compartments

ICFICF55~7555~75

IntravascularIntravascularplasmaplasma

X 50~70 X 50~70 lean body weightlean body weight

ExtravascularExtravascularInterstitial Interstitial

fluidfluid

TBWTBW

ECFECF

34

14

bull Male (55) gt female (45)bull Most concentrated in skeletal musclebull TBW=06xBWbull ICF=04xBWbull ECF=02xBW

23

13

Total body water (TBW)

bull TBW varies with age gender and body habitus

bull In adult males= 55 of body weight

bull In adult female=45 of body weight

bull In infant = 80 of body weight

bull Obese patients have less TBW per Kg than lean body

adult

1= Intracellular fluid (ICF)=55 TBW or 30-40 BW

2= Extracellular fluid (ECF) =45TBW or 20 BW

Interstitial fluid =15 of body weight

Intravascular fluid or plasma volume

= 5 of body weight

Body compartment fluid

Example men with 70kg TBW= 5570 =385 L

ICF = 55 385 =212L

ECF = 45 385=173L

1 ISF = 15 70 = 105L

2 PV = 5 70 =35L

Your User Name

Fluid compartments

ICF

Fluid compartments

ICF

ECF

Interstitial

Pla

sma

Fluid compartments

ICF

ECF

Interstitial

Pla

sma

Fluid compartments

ICF

ECF

Interstitial

Pla

sma

Capillary Membrane

Fluid compartments

ICF

ECF

Interstitial

Pla

sma

Capillary Membrane

Fluid compartments

ICF

ECF

Interstitial

Pla

sma

Capillary Membrane Cell Membrane

Colloid osmotic pressure

ECF

Interstitial

Pla

sma

Capillary Membrane

Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

Colloid osmotic pressure

ECF

Interstitial

Pla

sma

Capillary Membrane

Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

Colloid osmotic pressure

ECF

Interstitial

Pla

sma

Capillary Membrane

Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

H2O

H2O

Colloid osmotic pressure

ECF

Interstitial

Pla

sma

Capillary Membrane

Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

This is balanced out by the hydrostatic pressure difference

H2O

H2O12080

H2O

H2O

Cell Membrane

ICF

Cell Membrane

Interstitial

H2O

H2O

Cell membrane is freely permeable to H20 but

Cell Membrane

ICF

Cell Membrane

Na+

K+

Interstitial

H2O

H2O

Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

Cell Membrane

ICF

Cell Membrane

Na-

K+

Interstitial

H2O

H2O

Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

[K+] =4

Cell Membrane

ICF

Cell Membrane

Na-

K+

Interstitial

H2O

H2O

Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

[K+] =4 [K+] =150

Cell Membrane

ICF

Cell Membrane

Na-

K+

Interstitial

H2O

H2O

Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

[K+] =4 [K+] =150

Na+= 144

Cell Membrane

ICF

Cell Membrane

Na-

K+

Interstitial

H2O

H2O

Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

[K+] =4 [K+] =150

Na+= 144Na+= 10

Composition of Fluid Compartments

CATIONS ANIONS

Na+ 142 Cl - 103

HC03- 27

504mdash

3 PO4

---

K+ 4 organicCa++ 5 Acid 5

Mg++ 3 Protein 16

CATIONS ANIONS

Na+ 144 Cl - 114

HC03- 30

504mdash

K+ 4 3 PO4

---

organic

Ca++ 3 Acid 5

Mg++ 2 Protein 1

CATIONS ANIONS

K+ 150 HPO4

150 504

mdash

HCO3- 10

Mg++ 40 Protein 40

Na+ 10

154 mEqL 153 mEqL 153 mEqL154 mEqL

PLASMA INTERSTITAL FLID

200 mEqL 200 mEqL

INTRACELLULAR FLID

Composition of Body FluidsComposition of Body Fluids

Ca 2+

Mg 2+

K+

Na+

Cl-

PO43-

Organic anion

HCO3-

Protein

0

50

50

100

150

100

150

Cations Anions

EC

FICF

Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

والکترولیت آب تغییرات روی موثر عوامل

1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

عمل 2 از قبل والکترولیت آب وضعیت

اندوکرینوپاتی )3 همراه )بیماریهای

4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

Reasons for fluid therapyReasons for fluid therapy

Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

bull Correct hypovolaemiaCorrect hypovolaemia

bull Maintain cardiac outputMaintain cardiac output

bull Optimise gas exchangeOptimise gas exchange

bull Replace electrolytes amp waterReplace electrolytes amp water

bull Maintain urine outputMaintain urine output

Colloids + RBCs

Crystalloids

Identify what is the goal

Choose fluid which best achieves the goal

عروقی داخل مایع حجم ارزیابی

بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

وریدی محلولهای

Fluids bull Crystalloids

bull Colloids

bull blood

Which of the following solutions is isotonic

A D5W

B 045 saline

C 09 saline

D D5 in 09 saline

SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

ECFECF 142 4 5 103 27 280-310

Lactated Lactated RingerrsquosRingerrsquos

130 4 3 109 28 273

09 NaCl09 NaCl 154 154 308

045 045 NaClNaCl

77 77 154

D5WD5W

D5045 D5045 NaClNaCl

77 77 50 406

3 NaCl3 NaCl 513 513 1026

6 6 HetastarchHetastarch

500 154 154 310

5 5 AlbuminAlbumin

250500130-160

lt25130-160

330

25 25 AlbuminAlbumin

2050100130-160

lt25130-160

330

Common parenteral fluid therapyCommon parenteral fluid therapy

CrystalloidsCrystalloids

bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

Colloid SolutionsColloid Solutions

bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

- Haes-steril 10

الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

osm=273

09Nacl

bull Na=154

bull CL= 154

کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

PH=56است

Postoperative (maintenance)

045Nacl +5 dextrose +KCL

Perioperative management of fluid balance include

1 Preoperative evaluation

2 Intraoperative maintenance

3 Replacement of fluid losses

Preexisting fluid deficits

bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

bull Hypotonic fluid (05 saline ) or isotonic crystalloids

Maintenance requirements

bull Up to 10 kg = 4cckghr

bull 11-20kg = add 2cckghr

bull 21kg and above = add 1cckghr

bull Insensible losses = 2cckghr

Surgical fluid losses

Blood loss (measurement)

1 Suction container

2 Surgical sponge

3 Hct and tachycardia not specific

4 ABG and UO if hypoperfusion occur

5 Blood loss=31 with crystalloid

Other losses (third space loss)

Third space loss

1 Minimal (herniorrapy) =2-4cckghr

2 Moderate (cholecystectomy)=4-6cckghr

3 Severe (bowel resection) = 6-8cckghr

Crystalloid solution

1 The main solutions is either glucose or saline

2 Hypotonic or isotonic or hypertonic

3 Safe nontoxic reaction free inexpensive

4 Complication is edema if large volumes are needed

5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

Colloids

1 Albumin

2 Hydroxyethyl starch

3 Dextran

Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

factor )These colloid is best avoided in patients with

coagulopaty

The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

1000cc

500cc

500cc

500cc

200

600

1000

Lactated Ringers

5 Albumin

6 Hetastarch

Whole blood

Blood volumeInfusion volume

Colloid versus crystalloid solutions

Transfusion consideration

bull HB lt7 mg dl increase CO

bull Ideal Hb is 7-8 mgdl

bull In IHD patients or pulmonary disease gt 10 mgdl

بدن مایعات حجم در اختالل

1 Fluid volume deficit

2 Fluid volume excess

Fluid volume deficit(FVD)

) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

باشد آن با همراه دیگری اختالل مگر

DEHYDRATION

سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

سلولی خارج حجم کاهش علل

1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

Signs of HypovolemiaSigns of Hypovolemia

bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

Signs of HypervolemiaSigns of Hypervolemia

bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

Especially when hypo-albuminemia

Management of Management of HypervolemiaHypervolemia

bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

Fluid ManagementFluid Management

bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

Electrolyte physiology

Sodium physiology

Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

Normal amount 135-145 meql

Osmotic Pressure

Calculated serum osmolality =

2 sodium+ glucose18 + BUN 28

Osmolality = 290 mosm

Concentration

1Serum sodium concentration2Serum osmolarity

bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

DW5)

Hypernatremia

Serum Nagt145mEqL

- Hypernatremia

Loss of Free Water

Gain of sodium in excess of water

Hypernatremia

-Hypernatremia Hypo volemic

Hyper volemic

Normo volemic

Hypernatremia

Volume Status

Normal

Nonrenal water loss

Skin

Gastrointestinal

Renal water loss

Renal disease

Diuretics

Diabetes insipidus

High

Iatrogenic sodium administration

Mineralocorticoid excess

Aldosteronism

Cushingrsquos disease

Congenital adrenal

hyperplasia

Low

Nonrenal water loss

Skin

Gastrointestinal losses

Renal water losses

Renal (tubular) Diuretics

Osmotic diuretics

Diabetes insipidus

Adrenal failure

Asymptomatic

Hypernatremia Symptomatic (Nagt160 meqL)

Clinical Manifestations of Abnormalities in Serum Sodium

Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

Body system hypernatremia

Treatment

Normal saline in hypovolemic patients

Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

saline or entral water)

Water deficit (L)= times TBW

The formula used to estimate the amount of water required to correct hypernatremia

Estimate TBW as 55 of lean body mass in men and 45 in women

Serum sodium-140

140

The rate of fluid administration

1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

Hyponatremia Nalt135mEqL

Causes

1 Sodium depletion

2 Sodium dilution

bull Incidence = 45

bull After surgery=1

bull Mortality = 2 times normal

Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

volume deficit

Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

Sign and symptoms

bull CNS symptom when Nalt123 meql

bull Cardiac symptom when Nalt100 meql

For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

Body System Hyponatremia

central nervous system Headache confusion hyper-or hypoactive deep tendon

reflexes seizures coma increased intracranial pressure

Musculoskeletal Weakness fatigue muscle crampstwitching

Gastrointestinal Anorexia nausea vomiting watery diarrhea

Cardiovascular Hypertension and bradycardia if significant increases in

intracranial pressure

Tissue Lacrimation salivation

Renal Oliguria

Clinical Manifestations of Abnormalities in Serum Sodium

Treatment

1=Depend on ECF

2=CNS sign

Treatment

1 Asymptomatic increase the sodium level by no more than

05-1 meqLh to a maximum increase of 12 meqL per day

2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

more than 1meqL per hour until the serum Na level reaches 130

meqL or neurologic symptoms are improved

Rapid correction of hyponatremia

Pontine myelinolysis

Seizures weaknessparesis akinetic

movements unresponsiveness

Permanent brain damage

Death

Dose

Na deficit meq =(140- Na meql) TBW

باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

شود اصالح آهسته سپس

Potassium abnormalities

bull The average dietary intake of potassium 50-100meqd

bull The average renal excretion of potassium 10-700 meqd

- 2 of the total body potassium in ECF (45meqL)

- Factors that influence serum potassium

1 Surgical stress

2 Injury

3 Acidosis

4 Tissue catabolism

Hyperkalemia

The normal range of serum potassium 35-5 meqL

Etiology of Hyperkalemia

Increased intake Potassium supplementation

Blood transfusions

Endogenous loaddestruction

hemolysis rhabdomyolysis

cruch injury gastrointestinal hemorrhage

Increased release Acidosis

Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

Renal insufficiencyfailure

Clinical manifestation of hyperkalemia

System hyperkalemia

Gastrointestinal Nauseavomiting colic diarrhea

Neuromuscular weakness paralysis respiratory failure

Cardiovascular Arrhythmia arrest

ECG changes Peaked T waves (early change)

Flattened P wave

Prolonged PR interval (first-degree block)

Widened QRS complex

Sine wave formation

Ventricular fibrillation

Treatment

Treatment of symptomatic hyperkalemia

Potassium removal Kayexalate

Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

Rectal administration is 50 g in 200 mL 20 sorbitol

Dialysis

Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

Bicarbonate 1 vial intravenous

Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

HypokalemiaEtiology

inadequate intake

Dietary potassium-free intravenous fluids potassium-deficient

total parenteral nutrition

Excessive potassium excretion

Hyperaldosteronism

Medications

Gastrointestinal losses

Direct loss of potassium from gastrointestinal fluid (diarrhea)

Renal loss of potassium (gastric fluid either as vomiting or high

nasogastric output)

Intracellular-shift (metabolic alkalosis or insulin therapy)

Potassium changes associated with alkalosis

Potassium decrease by 03 meqL for every 01

increase in PH above normal

Magnesium Depletion

(drug induced amphotericin amioglycosides cisplatin)

Renal potassium wastage

Hypokalemia

Magnesium Depletion

(drug induced amphotericin amioglycosides cisplatin)

Renal potassium wastage

Hypokalemia

Clinical Manifestation of Abnormalities in potassium

System hypokalemia

Gastrointestinal Ileus constipation

Neuromuscular Decreased reflexes fatigue weakness

paralysis

Cardiovascular Arrest

ECG changes U-waves

T-wave flattening

ST-segment changes

Arrhythmias

Treatment

Potassium

Serum potassium level lt40 mEqL

Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

times 1 doses

Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

Symptomatic KC1 20 mEq IV q1h times 4 doses

Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

asymptomatic replace as per above protocol

Electrolyte Replacement Therapy Protocol

bull Oral repletion for mild and asymptomatic hypokalemia

bull IV repletion for severe and symptomatic hypokalemia

Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

( دندانها( ndash استخوانbull كلسيم نقش

عصبي 1 ايمپالسهاي )NMJ(انتقال

صاف 2 عضالت انقباض

هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

انعقاد 4

یونیزه Calt45 meql هيپوكلسمي

عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

( شود می پیوند شده

هیپوکلسمی عالئم

رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

سایرعالئم

قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

درمان

ای bull زمینه علت کردن طرف بروریدی bull کلسیم

Cagt55meql هيپركلسمي

هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

عالئم

bullGI

bullCardiovascular bullRenal (polyuria)

bullCNS

قلبی عالئم

bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

QRS شدن )Q-Tوكوتاه

درمان

ایزوتونیک 1 نمکی محلول انفوزیون

الزیکس2

تونین 3 کلسی

کورتون4

دیالیز5

Magnesium Abnormalities

Normal dietary intake 20meq (240mg)

Excretion in both the feces and urine

Normal serum level 19-25 mgdL

منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

Hypermagnesemia

Etiology

1 Impaired renal function

2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

Clinical manifestation hypermanesemia

System hypermanesemia

Gastrointestinal Nauseavomiting

Neuromuscular weakness lethargy Decreased

reflexes

Cardiovascular Hypotension arrest

ECG changes Increased PR interval

Widened QRS complex

Elevated T waves

Treatment

1 Withhold exogenous sources of magnesium

2 Correct volume deficit

3 Correct acidosis if present

4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

5 Dialysis (if elevated levels or symptoms persist)

عالئم

bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

meqL

Hypomagnesemia

Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

homeostasis

Etiology

1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

inadequate supplementation of magnesium)

2 Increased renal excretion (alcohol most diuretics and amphotericin B)

3 GI losses (diarrhea)

4 Malabsorption

5 Acute pancreatitis

6 Diabetic ketoacidosis

7 Primary aldosteronism

Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

2 Delirium and seizures in severe deficiency

3 ECG changes Prolonged QT and PR interval

ST-segment depression

Flattening or inversion of P waves

Torsades de pointes

Arrhythmia

Treatment

1 For asymptomatic and mild hypomagnesemia administer oral mg

2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

Message for Today

ICF

Interstitial

Pla

sma

5 Dex

bull Do not reccussitate sick patients with any Dextrose solution

  • Fluid and Electrolyte Management of the Surgical Patient
  • Slide 2
  • Slide 3
  • Slide 4
  • Total Body Water
  • Body Fluid Compartments
  • Total body water (TBW)
  • Body compartment fluid
  • Example men with 70kg
  • Fluid compartments
  • Slide 11
  • Slide 12
  • Slide 13
  • Slide 14
  • Slide 15
  • Colloid osmotic pressure
  • Slide 17
  • Slide 18
  • Slide 19
  • Cell Membrane
  • Slide 21
  • Slide 22
  • Slide 23
  • Slide 24
  • Slide 25
  • Composition of Fluid Compartments
  • Composition of Body Fluids
  • عوامل موثر روی تغییرات آب والکترولیت
  • Reasons for fluid therapy
  • ارزیابی حجم مایع داخل عروقی
  • محلولهای وریدی
  • Fluids
  • Slide 33
  • Slide 34
  • Slide 35
  • Crystalloids
  • Colloid Solutions
  • رینگر لاکتات
  • 09Nacl
  • Postoperative (maintenance)
  • Slide 41
  • Preexisting fluid deficits
  • Maintenance requirements
  • Surgical fluid losses
  • Third space loss
  • Crystalloid solution
  • Colloids
  • Complications
  • The Influence of Colloid amp Crystalloid on Blood Volume
  • Colloid versus crystalloid solutions
  • Transfusion consideration
  • اختلال در حجم مایعات بدن
  • Fluid volume deficit (FVD)
  • DEHYDRATION
  • علل کاهش حجم خارج سلولی
  • Signs of Hypovolemia
  • Clinical Diagnosis of Hypovolemia
  • Signs of Hypervolemia
  • Management of Hypervolemia
  • Fluid Management
  • Electrolyte physiology
  • Sodium physiology
  • Osmotic Pressure
  • Concentration
  • Hypernatremia
  • - Hypernatremia
  • Slide 67
  • Slide 68
  • Clinical Manifestations of Abnormalities in Serum Sodium
  • Treatment
  • Water deficit (L)= times TBW
  • The rate of fluid administration
  • Hyponatremia Nalt135mEqL
  • Slide 74
  • Sodium depletion
  • Sodium dilution
  • Sign and symptoms
  • Slide 78
  • Treatment
  • Slide 80
  • Slide 81
  • Dose
  • Potassium abnormalities
  • Hyperkalemia
  • Clinical manifestation of hyperkalemia
  • Slide 86
  • Slide 87
  • Hypokalemia
  • Potassium changes associated with alkalosis
  • Slide 90
  • Clinical Manifestation of Abnormalities in potassium
  • Slide 92
  • Calcium
  • هيپوكلسمي یونیزه Calt45 meql
  • علائم هیپوکلسمی
  • Slide 96
  • Slide 97
  • Slide 98
  • Slide 99
  • سایرعلائم
  • درمان
  • هيپركلسمي Cagt55meql
  • علائم
  • علائم قلبی
  • Slide 105
  • Magnesium Abnormalities
  • منیزیوم
  • Hypermagnesemia
  • Clinical manifestation hypermanesemia
  • Slide 110
  • Slide 111
  • Hypomagnesemia
  • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
  • Slide 114
  • Message for Today
  • Slide 116

    Fluid therapy is often poorly taught poorly understood and

    poorly done

    lsquolsquoFluid therapy should be directed not only to Fluid therapy should be directed not only to effective volume expansion of a leaky effective volume expansion of a leaky circulation but also to micro vascular circulation but also to micro vascular protectionrsquoprotectionrsquo

    Fluid and electrolyte management are paramount to the care of the surgical patient Changes in both fluid volume and electrolyte composition occur preoperatively intraoperatively and post operatively as well as in response to trauma and sepsis

    Total Body Water

    Who is having higher proportion of body weight as water And Why

    1048699Males or Females

    1048699Lean or Obese

    1048699Young or elderly

    Body Fluid CompartmentsBody Fluid Compartments

    ICFICF55~7555~75

    IntravascularIntravascularplasmaplasma

    X 50~70 X 50~70 lean body weightlean body weight

    ExtravascularExtravascularInterstitial Interstitial

    fluidfluid

    TBWTBW

    ECFECF

    34

    14

    bull Male (55) gt female (45)bull Most concentrated in skeletal musclebull TBW=06xBWbull ICF=04xBWbull ECF=02xBW

    23

    13

    Total body water (TBW)

    bull TBW varies with age gender and body habitus

    bull In adult males= 55 of body weight

    bull In adult female=45 of body weight

    bull In infant = 80 of body weight

    bull Obese patients have less TBW per Kg than lean body

    adult

    1= Intracellular fluid (ICF)=55 TBW or 30-40 BW

    2= Extracellular fluid (ECF) =45TBW or 20 BW

    Interstitial fluid =15 of body weight

    Intravascular fluid or plasma volume

    = 5 of body weight

    Body compartment fluid

    Example men with 70kg TBW= 5570 =385 L

    ICF = 55 385 =212L

    ECF = 45 385=173L

    1 ISF = 15 70 = 105L

    2 PV = 5 70 =35L

    Your User Name

    Fluid compartments

    ICF

    Fluid compartments

    ICF

    ECF

    Interstitial

    Pla

    sma

    Fluid compartments

    ICF

    ECF

    Interstitial

    Pla

    sma

    Fluid compartments

    ICF

    ECF

    Interstitial

    Pla

    sma

    Capillary Membrane

    Fluid compartments

    ICF

    ECF

    Interstitial

    Pla

    sma

    Capillary Membrane

    Fluid compartments

    ICF

    ECF

    Interstitial

    Pla

    sma

    Capillary Membrane Cell Membrane

    Colloid osmotic pressure

    ECF

    Interstitial

    Pla

    sma

    Capillary Membrane

    Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

    Colloid osmotic pressure

    ECF

    Interstitial

    Pla

    sma

    Capillary Membrane

    Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

    Colloid osmotic pressure

    ECF

    Interstitial

    Pla

    sma

    Capillary Membrane

    Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

    The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

    H2O

    H2O

    Colloid osmotic pressure

    ECF

    Interstitial

    Pla

    sma

    Capillary Membrane

    Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

    The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

    This is balanced out by the hydrostatic pressure difference

    H2O

    H2O12080

    H2O

    H2O

    Cell Membrane

    ICF

    Cell Membrane

    Interstitial

    H2O

    H2O

    Cell membrane is freely permeable to H20 but

    Cell Membrane

    ICF

    Cell Membrane

    Na+

    K+

    Interstitial

    H2O

    H2O

    Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

    Cell Membrane

    ICF

    Cell Membrane

    Na-

    K+

    Interstitial

    H2O

    H2O

    Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

    [K+] =4

    Cell Membrane

    ICF

    Cell Membrane

    Na-

    K+

    Interstitial

    H2O

    H2O

    Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

    [K+] =4 [K+] =150

    Cell Membrane

    ICF

    Cell Membrane

    Na-

    K+

    Interstitial

    H2O

    H2O

    Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

    [K+] =4 [K+] =150

    Na+= 144

    Cell Membrane

    ICF

    Cell Membrane

    Na-

    K+

    Interstitial

    H2O

    H2O

    Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

    [K+] =4 [K+] =150

    Na+= 144Na+= 10

    Composition of Fluid Compartments

    CATIONS ANIONS

    Na+ 142 Cl - 103

    HC03- 27

    504mdash

    3 PO4

    ---

    K+ 4 organicCa++ 5 Acid 5

    Mg++ 3 Protein 16

    CATIONS ANIONS

    Na+ 144 Cl - 114

    HC03- 30

    504mdash

    K+ 4 3 PO4

    ---

    organic

    Ca++ 3 Acid 5

    Mg++ 2 Protein 1

    CATIONS ANIONS

    K+ 150 HPO4

    150 504

    mdash

    HCO3- 10

    Mg++ 40 Protein 40

    Na+ 10

    154 mEqL 153 mEqL 153 mEqL154 mEqL

    PLASMA INTERSTITAL FLID

    200 mEqL 200 mEqL

    INTRACELLULAR FLID

    Composition of Body FluidsComposition of Body Fluids

    Ca 2+

    Mg 2+

    K+

    Na+

    Cl-

    PO43-

    Organic anion

    HCO3-

    Protein

    0

    50

    50

    100

    150

    100

    150

    Cations Anions

    EC

    FICF

    Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

    والکترولیت آب تغییرات روی موثر عوامل

    1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

    عمل 2 از قبل والکترولیت آب وضعیت

    اندوکرینوپاتی )3 همراه )بیماریهای

    4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

    Reasons for fluid therapyReasons for fluid therapy

    Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

    bull Correct hypovolaemiaCorrect hypovolaemia

    bull Maintain cardiac outputMaintain cardiac output

    bull Optimise gas exchangeOptimise gas exchange

    bull Replace electrolytes amp waterReplace electrolytes amp water

    bull Maintain urine outputMaintain urine output

    Colloids + RBCs

    Crystalloids

    Identify what is the goal

    Choose fluid which best achieves the goal

    عروقی داخل مایع حجم ارزیابی

    بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

    وریدی محلولهای

    Fluids bull Crystalloids

    bull Colloids

    bull blood

    Which of the following solutions is isotonic

    A D5W

    B 045 saline

    C 09 saline

    D D5 in 09 saline

    SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

    ECFECF 142 4 5 103 27 280-310

    Lactated Lactated RingerrsquosRingerrsquos

    130 4 3 109 28 273

    09 NaCl09 NaCl 154 154 308

    045 045 NaClNaCl

    77 77 154

    D5WD5W

    D5045 D5045 NaClNaCl

    77 77 50 406

    3 NaCl3 NaCl 513 513 1026

    6 6 HetastarchHetastarch

    500 154 154 310

    5 5 AlbuminAlbumin

    250500130-160

    lt25130-160

    330

    25 25 AlbuminAlbumin

    2050100130-160

    lt25130-160

    330

    Common parenteral fluid therapyCommon parenteral fluid therapy

    CrystalloidsCrystalloids

    bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

    Colloid SolutionsColloid Solutions

    bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

    - Haes-steril 10

    الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

    کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

    ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

    osm=273

    09Nacl

    bull Na=154

    bull CL= 154

    کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

    PH=56است

    Postoperative (maintenance)

    045Nacl +5 dextrose +KCL

    Perioperative management of fluid balance include

    1 Preoperative evaluation

    2 Intraoperative maintenance

    3 Replacement of fluid losses

    Preexisting fluid deficits

    bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

    bull Hypotonic fluid (05 saline ) or isotonic crystalloids

    Maintenance requirements

    bull Up to 10 kg = 4cckghr

    bull 11-20kg = add 2cckghr

    bull 21kg and above = add 1cckghr

    bull Insensible losses = 2cckghr

    Surgical fluid losses

    Blood loss (measurement)

    1 Suction container

    2 Surgical sponge

    3 Hct and tachycardia not specific

    4 ABG and UO if hypoperfusion occur

    5 Blood loss=31 with crystalloid

    Other losses (third space loss)

    Third space loss

    1 Minimal (herniorrapy) =2-4cckghr

    2 Moderate (cholecystectomy)=4-6cckghr

    3 Severe (bowel resection) = 6-8cckghr

    Crystalloid solution

    1 The main solutions is either glucose or saline

    2 Hypotonic or isotonic or hypertonic

    3 Safe nontoxic reaction free inexpensive

    4 Complication is edema if large volumes are needed

    5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

    Colloids

    1 Albumin

    2 Hydroxyethyl starch

    3 Dextran

    Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

    factor )These colloid is best avoided in patients with

    coagulopaty

    The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

    1000cc

    500cc

    500cc

    500cc

    200

    600

    1000

    Lactated Ringers

    5 Albumin

    6 Hetastarch

    Whole blood

    Blood volumeInfusion volume

    Colloid versus crystalloid solutions

    Transfusion consideration

    bull HB lt7 mg dl increase CO

    bull Ideal Hb is 7-8 mgdl

    bull In IHD patients or pulmonary disease gt 10 mgdl

    بدن مایعات حجم در اختالل

    1 Fluid volume deficit

    2 Fluid volume excess

    Fluid volume deficit(FVD)

    ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

    کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

    ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

    باشد آن با همراه دیگری اختالل مگر

    DEHYDRATION

    سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

    سلولی خارج حجم کاهش علل

    1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

    2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

    کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

    Signs of HypovolemiaSigns of Hypovolemia

    bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

    Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

    bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

    Signs of HypervolemiaSigns of Hypervolemia

    bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

    Especially when hypo-albuminemia

    Management of Management of HypervolemiaHypervolemia

    bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

    Fluid ManagementFluid Management

    bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

    Electrolyte physiology

    Sodium physiology

    Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

    Normal amount 135-145 meql

    Osmotic Pressure

    Calculated serum osmolality =

    2 sodium+ glucose18 + BUN 28

    Osmolality = 290 mosm

    Concentration

    1Serum sodium concentration2Serum osmolarity

    bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

    drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

    DW5)

    Hypernatremia

    Serum Nagt145mEqL

    - Hypernatremia

    Loss of Free Water

    Gain of sodium in excess of water

    Hypernatremia

    -Hypernatremia Hypo volemic

    Hyper volemic

    Normo volemic

    Hypernatremia

    Volume Status

    Normal

    Nonrenal water loss

    Skin

    Gastrointestinal

    Renal water loss

    Renal disease

    Diuretics

    Diabetes insipidus

    High

    Iatrogenic sodium administration

    Mineralocorticoid excess

    Aldosteronism

    Cushingrsquos disease

    Congenital adrenal

    hyperplasia

    Low

    Nonrenal water loss

    Skin

    Gastrointestinal losses

    Renal water losses

    Renal (tubular) Diuretics

    Osmotic diuretics

    Diabetes insipidus

    Adrenal failure

    Asymptomatic

    Hypernatremia Symptomatic (Nagt160 meqL)

    Clinical Manifestations of Abnormalities in Serum Sodium

    Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

    Body system hypernatremia

    Treatment

    Normal saline in hypovolemic patients

    Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

    saline or entral water)

    Water deficit (L)= times TBW

    The formula used to estimate the amount of water required to correct hypernatremia

    Estimate TBW as 55 of lean body mass in men and 45 in women

    Serum sodium-140

    140

    The rate of fluid administration

    1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

    2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

    Hyponatremia Nalt135mEqL

    Causes

    1 Sodium depletion

    2 Sodium dilution

    bull Incidence = 45

    bull After surgery=1

    bull Mortality = 2 times normal

    Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

    volume deficit

    Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

    Sign and symptoms

    bull CNS symptom when Nalt123 meql

    bull Cardiac symptom when Nalt100 meql

    For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

    Body System Hyponatremia

    central nervous system Headache confusion hyper-or hypoactive deep tendon

    reflexes seizures coma increased intracranial pressure

    Musculoskeletal Weakness fatigue muscle crampstwitching

    Gastrointestinal Anorexia nausea vomiting watery diarrhea

    Cardiovascular Hypertension and bradycardia if significant increases in

    intracranial pressure

    Tissue Lacrimation salivation

    Renal Oliguria

    Clinical Manifestations of Abnormalities in Serum Sodium

    Treatment

    1=Depend on ECF

    2=CNS sign

    Treatment

    1 Asymptomatic increase the sodium level by no more than

    05-1 meqLh to a maximum increase of 12 meqL per day

    2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

    more than 1meqL per hour until the serum Na level reaches 130

    meqL or neurologic symptoms are improved

    Rapid correction of hyponatremia

    Pontine myelinolysis

    Seizures weaknessparesis akinetic

    movements unresponsiveness

    Permanent brain damage

    Death

    Dose

    Na deficit meq =(140- Na meql) TBW

    باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

    شود اصالح آهسته سپس

    Potassium abnormalities

    bull The average dietary intake of potassium 50-100meqd

    bull The average renal excretion of potassium 10-700 meqd

    - 2 of the total body potassium in ECF (45meqL)

    - Factors that influence serum potassium

    1 Surgical stress

    2 Injury

    3 Acidosis

    4 Tissue catabolism

    Hyperkalemia

    The normal range of serum potassium 35-5 meqL

    Etiology of Hyperkalemia

    Increased intake Potassium supplementation

    Blood transfusions

    Endogenous loaddestruction

    hemolysis rhabdomyolysis

    cruch injury gastrointestinal hemorrhage

    Increased release Acidosis

    Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

    Renal insufficiencyfailure

    Clinical manifestation of hyperkalemia

    System hyperkalemia

    Gastrointestinal Nauseavomiting colic diarrhea

    Neuromuscular weakness paralysis respiratory failure

    Cardiovascular Arrhythmia arrest

    ECG changes Peaked T waves (early change)

    Flattened P wave

    Prolonged PR interval (first-degree block)

    Widened QRS complex

    Sine wave formation

    Ventricular fibrillation

    Treatment

    Treatment of symptomatic hyperkalemia

    Potassium removal Kayexalate

    Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

    Rectal administration is 50 g in 200 mL 20 sorbitol

    Dialysis

    Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

    Bicarbonate 1 vial intravenous

    Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

    HypokalemiaEtiology

    inadequate intake

    Dietary potassium-free intravenous fluids potassium-deficient

    total parenteral nutrition

    Excessive potassium excretion

    Hyperaldosteronism

    Medications

    Gastrointestinal losses

    Direct loss of potassium from gastrointestinal fluid (diarrhea)

    Renal loss of potassium (gastric fluid either as vomiting or high

    nasogastric output)

    Intracellular-shift (metabolic alkalosis or insulin therapy)

    Potassium changes associated with alkalosis

    Potassium decrease by 03 meqL for every 01

    increase in PH above normal

    Magnesium Depletion

    (drug induced amphotericin amioglycosides cisplatin)

    Renal potassium wastage

    Hypokalemia

    Magnesium Depletion

    (drug induced amphotericin amioglycosides cisplatin)

    Renal potassium wastage

    Hypokalemia

    Clinical Manifestation of Abnormalities in potassium

    System hypokalemia

    Gastrointestinal Ileus constipation

    Neuromuscular Decreased reflexes fatigue weakness

    paralysis

    Cardiovascular Arrest

    ECG changes U-waves

    T-wave flattening

    ST-segment changes

    Arrhythmias

    Treatment

    Potassium

    Serum potassium level lt40 mEqL

    Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

    times 1 doses

    Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

    Symptomatic KC1 20 mEq IV q1h times 4 doses

    Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

    asymptomatic replace as per above protocol

    Electrolyte Replacement Therapy Protocol

    bull Oral repletion for mild and asymptomatic hypokalemia

    bull IV repletion for severe and symptomatic hypokalemia

    Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

    ( دندانها( ndash استخوانbull كلسيم نقش

    عصبي 1 ايمپالسهاي )NMJ(انتقال

    صاف 2 عضالت انقباض

    هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

    انعقاد 4

    یونیزه Calt45 meql هيپوكلسمي

    عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

    ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

    میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

    ( شود می پیوند شده

    هیپوکلسمی عالئم

    رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

    سایرعالئم

    قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

    درمان

    ای bull زمینه علت کردن طرف بروریدی bull کلسیم

    Cagt55meql هيپركلسمي

    هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

    عالئم

    bullGI

    bullCardiovascular bullRenal (polyuria)

    bullCNS

    قلبی عالئم

    bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

    QRS شدن )Q-Tوكوتاه

    درمان

    ایزوتونیک 1 نمکی محلول انفوزیون

    الزیکس2

    تونین 3 کلسی

    کورتون4

    دیالیز5

    Magnesium Abnormalities

    Normal dietary intake 20meq (240mg)

    Excretion in both the feces and urine

    Normal serum level 19-25 mgdL

    منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

    تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

    bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

    Hypermagnesemia

    Etiology

    1 Impaired renal function

    2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

    Clinical manifestation hypermanesemia

    System hypermanesemia

    Gastrointestinal Nauseavomiting

    Neuromuscular weakness lethargy Decreased

    reflexes

    Cardiovascular Hypotension arrest

    ECG changes Increased PR interval

    Widened QRS complex

    Elevated T waves

    Treatment

    1 Withhold exogenous sources of magnesium

    2 Correct volume deficit

    3 Correct acidosis if present

    4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

    5 Dialysis (if elevated levels or symptoms persist)

    عالئم

    bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

    meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

    meqL

    Hypomagnesemia

    Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

    homeostasis

    Etiology

    1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

    inadequate supplementation of magnesium)

    2 Increased renal excretion (alcohol most diuretics and amphotericin B)

    3 GI losses (diarrhea)

    4 Malabsorption

    5 Acute pancreatitis

    6 Diabetic ketoacidosis

    7 Primary aldosteronism

    Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

    1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

    2 Delirium and seizures in severe deficiency

    3 ECG changes Prolonged QT and PR interval

    ST-segment depression

    Flattening or inversion of P waves

    Torsades de pointes

    Arrhythmia

    Treatment

    1 For asymptomatic and mild hypomagnesemia administer oral mg

    2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

    Message for Today

    ICF

    Interstitial

    Pla

    sma

    5 Dex

    bull Do not reccussitate sick patients with any Dextrose solution

    • Fluid and Electrolyte Management of the Surgical Patient
    • Slide 2
    • Slide 3
    • Slide 4
    • Total Body Water
    • Body Fluid Compartments
    • Total body water (TBW)
    • Body compartment fluid
    • Example men with 70kg
    • Fluid compartments
    • Slide 11
    • Slide 12
    • Slide 13
    • Slide 14
    • Slide 15
    • Colloid osmotic pressure
    • Slide 17
    • Slide 18
    • Slide 19
    • Cell Membrane
    • Slide 21
    • Slide 22
    • Slide 23
    • Slide 24
    • Slide 25
    • Composition of Fluid Compartments
    • Composition of Body Fluids
    • عوامل موثر روی تغییرات آب والکترولیت
    • Reasons for fluid therapy
    • ارزیابی حجم مایع داخل عروقی
    • محلولهای وریدی
    • Fluids
    • Slide 33
    • Slide 34
    • Slide 35
    • Crystalloids
    • Colloid Solutions
    • رینگر لاکتات
    • 09Nacl
    • Postoperative (maintenance)
    • Slide 41
    • Preexisting fluid deficits
    • Maintenance requirements
    • Surgical fluid losses
    • Third space loss
    • Crystalloid solution
    • Colloids
    • Complications
    • The Influence of Colloid amp Crystalloid on Blood Volume
    • Colloid versus crystalloid solutions
    • Transfusion consideration
    • اختلال در حجم مایعات بدن
    • Fluid volume deficit (FVD)
    • DEHYDRATION
    • علل کاهش حجم خارج سلولی
    • Signs of Hypovolemia
    • Clinical Diagnosis of Hypovolemia
    • Signs of Hypervolemia
    • Management of Hypervolemia
    • Fluid Management
    • Electrolyte physiology
    • Sodium physiology
    • Osmotic Pressure
    • Concentration
    • Hypernatremia
    • - Hypernatremia
    • Slide 67
    • Slide 68
    • Clinical Manifestations of Abnormalities in Serum Sodium
    • Treatment
    • Water deficit (L)= times TBW
    • The rate of fluid administration
    • Hyponatremia Nalt135mEqL
    • Slide 74
    • Sodium depletion
    • Sodium dilution
    • Sign and symptoms
    • Slide 78
    • Treatment
    • Slide 80
    • Slide 81
    • Dose
    • Potassium abnormalities
    • Hyperkalemia
    • Clinical manifestation of hyperkalemia
    • Slide 86
    • Slide 87
    • Hypokalemia
    • Potassium changes associated with alkalosis
    • Slide 90
    • Clinical Manifestation of Abnormalities in potassium
    • Slide 92
    • Calcium
    • هيپوكلسمي یونیزه Calt45 meql
    • علائم هیپوکلسمی
    • Slide 96
    • Slide 97
    • Slide 98
    • Slide 99
    • سایرعلائم
    • درمان
    • هيپركلسمي Cagt55meql
    • علائم
    • علائم قلبی
    • Slide 105
    • Magnesium Abnormalities
    • منیزیوم
    • Hypermagnesemia
    • Clinical manifestation hypermanesemia
    • Slide 110
    • Slide 111
    • Hypomagnesemia
    • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
    • Slide 114
    • Message for Today
    • Slide 116

      lsquolsquoFluid therapy should be directed not only to Fluid therapy should be directed not only to effective volume expansion of a leaky effective volume expansion of a leaky circulation but also to micro vascular circulation but also to micro vascular protectionrsquoprotectionrsquo

      Fluid and electrolyte management are paramount to the care of the surgical patient Changes in both fluid volume and electrolyte composition occur preoperatively intraoperatively and post operatively as well as in response to trauma and sepsis

      Total Body Water

      Who is having higher proportion of body weight as water And Why

      1048699Males or Females

      1048699Lean or Obese

      1048699Young or elderly

      Body Fluid CompartmentsBody Fluid Compartments

      ICFICF55~7555~75

      IntravascularIntravascularplasmaplasma

      X 50~70 X 50~70 lean body weightlean body weight

      ExtravascularExtravascularInterstitial Interstitial

      fluidfluid

      TBWTBW

      ECFECF

      34

      14

      bull Male (55) gt female (45)bull Most concentrated in skeletal musclebull TBW=06xBWbull ICF=04xBWbull ECF=02xBW

      23

      13

      Total body water (TBW)

      bull TBW varies with age gender and body habitus

      bull In adult males= 55 of body weight

      bull In adult female=45 of body weight

      bull In infant = 80 of body weight

      bull Obese patients have less TBW per Kg than lean body

      adult

      1= Intracellular fluid (ICF)=55 TBW or 30-40 BW

      2= Extracellular fluid (ECF) =45TBW or 20 BW

      Interstitial fluid =15 of body weight

      Intravascular fluid or plasma volume

      = 5 of body weight

      Body compartment fluid

      Example men with 70kg TBW= 5570 =385 L

      ICF = 55 385 =212L

      ECF = 45 385=173L

      1 ISF = 15 70 = 105L

      2 PV = 5 70 =35L

      Your User Name

      Fluid compartments

      ICF

      Fluid compartments

      ICF

      ECF

      Interstitial

      Pla

      sma

      Fluid compartments

      ICF

      ECF

      Interstitial

      Pla

      sma

      Fluid compartments

      ICF

      ECF

      Interstitial

      Pla

      sma

      Capillary Membrane

      Fluid compartments

      ICF

      ECF

      Interstitial

      Pla

      sma

      Capillary Membrane

      Fluid compartments

      ICF

      ECF

      Interstitial

      Pla

      sma

      Capillary Membrane Cell Membrane

      Colloid osmotic pressure

      ECF

      Interstitial

      Pla

      sma

      Capillary Membrane

      Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

      Colloid osmotic pressure

      ECF

      Interstitial

      Pla

      sma

      Capillary Membrane

      Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

      Colloid osmotic pressure

      ECF

      Interstitial

      Pla

      sma

      Capillary Membrane

      Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

      The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

      H2O

      H2O

      Colloid osmotic pressure

      ECF

      Interstitial

      Pla

      sma

      Capillary Membrane

      Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

      The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

      This is balanced out by the hydrostatic pressure difference

      H2O

      H2O12080

      H2O

      H2O

      Cell Membrane

      ICF

      Cell Membrane

      Interstitial

      H2O

      H2O

      Cell membrane is freely permeable to H20 but

      Cell Membrane

      ICF

      Cell Membrane

      Na+

      K+

      Interstitial

      H2O

      H2O

      Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

      Cell Membrane

      ICF

      Cell Membrane

      Na-

      K+

      Interstitial

      H2O

      H2O

      Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

      [K+] =4

      Cell Membrane

      ICF

      Cell Membrane

      Na-

      K+

      Interstitial

      H2O

      H2O

      Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

      [K+] =4 [K+] =150

      Cell Membrane

      ICF

      Cell Membrane

      Na-

      K+

      Interstitial

      H2O

      H2O

      Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

      [K+] =4 [K+] =150

      Na+= 144

      Cell Membrane

      ICF

      Cell Membrane

      Na-

      K+

      Interstitial

      H2O

      H2O

      Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

      [K+] =4 [K+] =150

      Na+= 144Na+= 10

      Composition of Fluid Compartments

      CATIONS ANIONS

      Na+ 142 Cl - 103

      HC03- 27

      504mdash

      3 PO4

      ---

      K+ 4 organicCa++ 5 Acid 5

      Mg++ 3 Protein 16

      CATIONS ANIONS

      Na+ 144 Cl - 114

      HC03- 30

      504mdash

      K+ 4 3 PO4

      ---

      organic

      Ca++ 3 Acid 5

      Mg++ 2 Protein 1

      CATIONS ANIONS

      K+ 150 HPO4

      150 504

      mdash

      HCO3- 10

      Mg++ 40 Protein 40

      Na+ 10

      154 mEqL 153 mEqL 153 mEqL154 mEqL

      PLASMA INTERSTITAL FLID

      200 mEqL 200 mEqL

      INTRACELLULAR FLID

      Composition of Body FluidsComposition of Body Fluids

      Ca 2+

      Mg 2+

      K+

      Na+

      Cl-

      PO43-

      Organic anion

      HCO3-

      Protein

      0

      50

      50

      100

      150

      100

      150

      Cations Anions

      EC

      FICF

      Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

      والکترولیت آب تغییرات روی موثر عوامل

      1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

      عمل 2 از قبل والکترولیت آب وضعیت

      اندوکرینوپاتی )3 همراه )بیماریهای

      4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

      Reasons for fluid therapyReasons for fluid therapy

      Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

      bull Correct hypovolaemiaCorrect hypovolaemia

      bull Maintain cardiac outputMaintain cardiac output

      bull Optimise gas exchangeOptimise gas exchange

      bull Replace electrolytes amp waterReplace electrolytes amp water

      bull Maintain urine outputMaintain urine output

      Colloids + RBCs

      Crystalloids

      Identify what is the goal

      Choose fluid which best achieves the goal

      عروقی داخل مایع حجم ارزیابی

      بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

      وریدی محلولهای

      Fluids bull Crystalloids

      bull Colloids

      bull blood

      Which of the following solutions is isotonic

      A D5W

      B 045 saline

      C 09 saline

      D D5 in 09 saline

      SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

      ECFECF 142 4 5 103 27 280-310

      Lactated Lactated RingerrsquosRingerrsquos

      130 4 3 109 28 273

      09 NaCl09 NaCl 154 154 308

      045 045 NaClNaCl

      77 77 154

      D5WD5W

      D5045 D5045 NaClNaCl

      77 77 50 406

      3 NaCl3 NaCl 513 513 1026

      6 6 HetastarchHetastarch

      500 154 154 310

      5 5 AlbuminAlbumin

      250500130-160

      lt25130-160

      330

      25 25 AlbuminAlbumin

      2050100130-160

      lt25130-160

      330

      Common parenteral fluid therapyCommon parenteral fluid therapy

      CrystalloidsCrystalloids

      bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

      Colloid SolutionsColloid Solutions

      bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

      - Haes-steril 10

      الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

      کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

      ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

      osm=273

      09Nacl

      bull Na=154

      bull CL= 154

      کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

      PH=56است

      Postoperative (maintenance)

      045Nacl +5 dextrose +KCL

      Perioperative management of fluid balance include

      1 Preoperative evaluation

      2 Intraoperative maintenance

      3 Replacement of fluid losses

      Preexisting fluid deficits

      bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

      bull Hypotonic fluid (05 saline ) or isotonic crystalloids

      Maintenance requirements

      bull Up to 10 kg = 4cckghr

      bull 11-20kg = add 2cckghr

      bull 21kg and above = add 1cckghr

      bull Insensible losses = 2cckghr

      Surgical fluid losses

      Blood loss (measurement)

      1 Suction container

      2 Surgical sponge

      3 Hct and tachycardia not specific

      4 ABG and UO if hypoperfusion occur

      5 Blood loss=31 with crystalloid

      Other losses (third space loss)

      Third space loss

      1 Minimal (herniorrapy) =2-4cckghr

      2 Moderate (cholecystectomy)=4-6cckghr

      3 Severe (bowel resection) = 6-8cckghr

      Crystalloid solution

      1 The main solutions is either glucose or saline

      2 Hypotonic or isotonic or hypertonic

      3 Safe nontoxic reaction free inexpensive

      4 Complication is edema if large volumes are needed

      5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

      Colloids

      1 Albumin

      2 Hydroxyethyl starch

      3 Dextran

      Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

      factor )These colloid is best avoided in patients with

      coagulopaty

      The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

      1000cc

      500cc

      500cc

      500cc

      200

      600

      1000

      Lactated Ringers

      5 Albumin

      6 Hetastarch

      Whole blood

      Blood volumeInfusion volume

      Colloid versus crystalloid solutions

      Transfusion consideration

      bull HB lt7 mg dl increase CO

      bull Ideal Hb is 7-8 mgdl

      bull In IHD patients or pulmonary disease gt 10 mgdl

      بدن مایعات حجم در اختالل

      1 Fluid volume deficit

      2 Fluid volume excess

      Fluid volume deficit(FVD)

      ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

      کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

      ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

      باشد آن با همراه دیگری اختالل مگر

      DEHYDRATION

      سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

      سلولی خارج حجم کاهش علل

      1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

      2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

      کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

      Signs of HypovolemiaSigns of Hypovolemia

      bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

      Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

      bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

      Signs of HypervolemiaSigns of Hypervolemia

      bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

      Especially when hypo-albuminemia

      Management of Management of HypervolemiaHypervolemia

      bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

      Fluid ManagementFluid Management

      bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

      Electrolyte physiology

      Sodium physiology

      Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

      Normal amount 135-145 meql

      Osmotic Pressure

      Calculated serum osmolality =

      2 sodium+ glucose18 + BUN 28

      Osmolality = 290 mosm

      Concentration

      1Serum sodium concentration2Serum osmolarity

      bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

      drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

      DW5)

      Hypernatremia

      Serum Nagt145mEqL

      - Hypernatremia

      Loss of Free Water

      Gain of sodium in excess of water

      Hypernatremia

      -Hypernatremia Hypo volemic

      Hyper volemic

      Normo volemic

      Hypernatremia

      Volume Status

      Normal

      Nonrenal water loss

      Skin

      Gastrointestinal

      Renal water loss

      Renal disease

      Diuretics

      Diabetes insipidus

      High

      Iatrogenic sodium administration

      Mineralocorticoid excess

      Aldosteronism

      Cushingrsquos disease

      Congenital adrenal

      hyperplasia

      Low

      Nonrenal water loss

      Skin

      Gastrointestinal losses

      Renal water losses

      Renal (tubular) Diuretics

      Osmotic diuretics

      Diabetes insipidus

      Adrenal failure

      Asymptomatic

      Hypernatremia Symptomatic (Nagt160 meqL)

      Clinical Manifestations of Abnormalities in Serum Sodium

      Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

      Body system hypernatremia

      Treatment

      Normal saline in hypovolemic patients

      Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

      saline or entral water)

      Water deficit (L)= times TBW

      The formula used to estimate the amount of water required to correct hypernatremia

      Estimate TBW as 55 of lean body mass in men and 45 in women

      Serum sodium-140

      140

      The rate of fluid administration

      1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

      2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

      Hyponatremia Nalt135mEqL

      Causes

      1 Sodium depletion

      2 Sodium dilution

      bull Incidence = 45

      bull After surgery=1

      bull Mortality = 2 times normal

      Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

      volume deficit

      Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

      Sign and symptoms

      bull CNS symptom when Nalt123 meql

      bull Cardiac symptom when Nalt100 meql

      For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

      Body System Hyponatremia

      central nervous system Headache confusion hyper-or hypoactive deep tendon

      reflexes seizures coma increased intracranial pressure

      Musculoskeletal Weakness fatigue muscle crampstwitching

      Gastrointestinal Anorexia nausea vomiting watery diarrhea

      Cardiovascular Hypertension and bradycardia if significant increases in

      intracranial pressure

      Tissue Lacrimation salivation

      Renal Oliguria

      Clinical Manifestations of Abnormalities in Serum Sodium

      Treatment

      1=Depend on ECF

      2=CNS sign

      Treatment

      1 Asymptomatic increase the sodium level by no more than

      05-1 meqLh to a maximum increase of 12 meqL per day

      2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

      more than 1meqL per hour until the serum Na level reaches 130

      meqL or neurologic symptoms are improved

      Rapid correction of hyponatremia

      Pontine myelinolysis

      Seizures weaknessparesis akinetic

      movements unresponsiveness

      Permanent brain damage

      Death

      Dose

      Na deficit meq =(140- Na meql) TBW

      باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

      شود اصالح آهسته سپس

      Potassium abnormalities

      bull The average dietary intake of potassium 50-100meqd

      bull The average renal excretion of potassium 10-700 meqd

      - 2 of the total body potassium in ECF (45meqL)

      - Factors that influence serum potassium

      1 Surgical stress

      2 Injury

      3 Acidosis

      4 Tissue catabolism

      Hyperkalemia

      The normal range of serum potassium 35-5 meqL

      Etiology of Hyperkalemia

      Increased intake Potassium supplementation

      Blood transfusions

      Endogenous loaddestruction

      hemolysis rhabdomyolysis

      cruch injury gastrointestinal hemorrhage

      Increased release Acidosis

      Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

      Renal insufficiencyfailure

      Clinical manifestation of hyperkalemia

      System hyperkalemia

      Gastrointestinal Nauseavomiting colic diarrhea

      Neuromuscular weakness paralysis respiratory failure

      Cardiovascular Arrhythmia arrest

      ECG changes Peaked T waves (early change)

      Flattened P wave

      Prolonged PR interval (first-degree block)

      Widened QRS complex

      Sine wave formation

      Ventricular fibrillation

      Treatment

      Treatment of symptomatic hyperkalemia

      Potassium removal Kayexalate

      Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

      Rectal administration is 50 g in 200 mL 20 sorbitol

      Dialysis

      Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

      Bicarbonate 1 vial intravenous

      Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

      HypokalemiaEtiology

      inadequate intake

      Dietary potassium-free intravenous fluids potassium-deficient

      total parenteral nutrition

      Excessive potassium excretion

      Hyperaldosteronism

      Medications

      Gastrointestinal losses

      Direct loss of potassium from gastrointestinal fluid (diarrhea)

      Renal loss of potassium (gastric fluid either as vomiting or high

      nasogastric output)

      Intracellular-shift (metabolic alkalosis or insulin therapy)

      Potassium changes associated with alkalosis

      Potassium decrease by 03 meqL for every 01

      increase in PH above normal

      Magnesium Depletion

      (drug induced amphotericin amioglycosides cisplatin)

      Renal potassium wastage

      Hypokalemia

      Magnesium Depletion

      (drug induced amphotericin amioglycosides cisplatin)

      Renal potassium wastage

      Hypokalemia

      Clinical Manifestation of Abnormalities in potassium

      System hypokalemia

      Gastrointestinal Ileus constipation

      Neuromuscular Decreased reflexes fatigue weakness

      paralysis

      Cardiovascular Arrest

      ECG changes U-waves

      T-wave flattening

      ST-segment changes

      Arrhythmias

      Treatment

      Potassium

      Serum potassium level lt40 mEqL

      Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

      times 1 doses

      Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

      Symptomatic KC1 20 mEq IV q1h times 4 doses

      Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

      asymptomatic replace as per above protocol

      Electrolyte Replacement Therapy Protocol

      bull Oral repletion for mild and asymptomatic hypokalemia

      bull IV repletion for severe and symptomatic hypokalemia

      Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

      ( دندانها( ndash استخوانbull كلسيم نقش

      عصبي 1 ايمپالسهاي )NMJ(انتقال

      صاف 2 عضالت انقباض

      هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

      انعقاد 4

      یونیزه Calt45 meql هيپوكلسمي

      عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

      ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

      میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

      ( شود می پیوند شده

      هیپوکلسمی عالئم

      رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

      سایرعالئم

      قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

      درمان

      ای bull زمینه علت کردن طرف بروریدی bull کلسیم

      Cagt55meql هيپركلسمي

      هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

      عالئم

      bullGI

      bullCardiovascular bullRenal (polyuria)

      bullCNS

      قلبی عالئم

      bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

      QRS شدن )Q-Tوكوتاه

      درمان

      ایزوتونیک 1 نمکی محلول انفوزیون

      الزیکس2

      تونین 3 کلسی

      کورتون4

      دیالیز5

      Magnesium Abnormalities

      Normal dietary intake 20meq (240mg)

      Excretion in both the feces and urine

      Normal serum level 19-25 mgdL

      منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

      تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

      bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

      Hypermagnesemia

      Etiology

      1 Impaired renal function

      2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

      Clinical manifestation hypermanesemia

      System hypermanesemia

      Gastrointestinal Nauseavomiting

      Neuromuscular weakness lethargy Decreased

      reflexes

      Cardiovascular Hypotension arrest

      ECG changes Increased PR interval

      Widened QRS complex

      Elevated T waves

      Treatment

      1 Withhold exogenous sources of magnesium

      2 Correct volume deficit

      3 Correct acidosis if present

      4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

      5 Dialysis (if elevated levels or symptoms persist)

      عالئم

      bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

      meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

      meqL

      Hypomagnesemia

      Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

      homeostasis

      Etiology

      1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

      inadequate supplementation of magnesium)

      2 Increased renal excretion (alcohol most diuretics and amphotericin B)

      3 GI losses (diarrhea)

      4 Malabsorption

      5 Acute pancreatitis

      6 Diabetic ketoacidosis

      7 Primary aldosteronism

      Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

      1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

      2 Delirium and seizures in severe deficiency

      3 ECG changes Prolonged QT and PR interval

      ST-segment depression

      Flattening or inversion of P waves

      Torsades de pointes

      Arrhythmia

      Treatment

      1 For asymptomatic and mild hypomagnesemia administer oral mg

      2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

      Message for Today

      ICF

      Interstitial

      Pla

      sma

      5 Dex

      bull Do not reccussitate sick patients with any Dextrose solution

      • Fluid and Electrolyte Management of the Surgical Patient
      • Slide 2
      • Slide 3
      • Slide 4
      • Total Body Water
      • Body Fluid Compartments
      • Total body water (TBW)
      • Body compartment fluid
      • Example men with 70kg
      • Fluid compartments
      • Slide 11
      • Slide 12
      • Slide 13
      • Slide 14
      • Slide 15
      • Colloid osmotic pressure
      • Slide 17
      • Slide 18
      • Slide 19
      • Cell Membrane
      • Slide 21
      • Slide 22
      • Slide 23
      • Slide 24
      • Slide 25
      • Composition of Fluid Compartments
      • Composition of Body Fluids
      • عوامل موثر روی تغییرات آب والکترولیت
      • Reasons for fluid therapy
      • ارزیابی حجم مایع داخل عروقی
      • محلولهای وریدی
      • Fluids
      • Slide 33
      • Slide 34
      • Slide 35
      • Crystalloids
      • Colloid Solutions
      • رینگر لاکتات
      • 09Nacl
      • Postoperative (maintenance)
      • Slide 41
      • Preexisting fluid deficits
      • Maintenance requirements
      • Surgical fluid losses
      • Third space loss
      • Crystalloid solution
      • Colloids
      • Complications
      • The Influence of Colloid amp Crystalloid on Blood Volume
      • Colloid versus crystalloid solutions
      • Transfusion consideration
      • اختلال در حجم مایعات بدن
      • Fluid volume deficit (FVD)
      • DEHYDRATION
      • علل کاهش حجم خارج سلولی
      • Signs of Hypovolemia
      • Clinical Diagnosis of Hypovolemia
      • Signs of Hypervolemia
      • Management of Hypervolemia
      • Fluid Management
      • Electrolyte physiology
      • Sodium physiology
      • Osmotic Pressure
      • Concentration
      • Hypernatremia
      • - Hypernatremia
      • Slide 67
      • Slide 68
      • Clinical Manifestations of Abnormalities in Serum Sodium
      • Treatment
      • Water deficit (L)= times TBW
      • The rate of fluid administration
      • Hyponatremia Nalt135mEqL
      • Slide 74
      • Sodium depletion
      • Sodium dilution
      • Sign and symptoms
      • Slide 78
      • Treatment
      • Slide 80
      • Slide 81
      • Dose
      • Potassium abnormalities
      • Hyperkalemia
      • Clinical manifestation of hyperkalemia
      • Slide 86
      • Slide 87
      • Hypokalemia
      • Potassium changes associated with alkalosis
      • Slide 90
      • Clinical Manifestation of Abnormalities in potassium
      • Slide 92
      • Calcium
      • هيپوكلسمي یونیزه Calt45 meql
      • علائم هیپوکلسمی
      • Slide 96
      • Slide 97
      • Slide 98
      • Slide 99
      • سایرعلائم
      • درمان
      • هيپركلسمي Cagt55meql
      • علائم
      • علائم قلبی
      • Slide 105
      • Magnesium Abnormalities
      • منیزیوم
      • Hypermagnesemia
      • Clinical manifestation hypermanesemia
      • Slide 110
      • Slide 111
      • Hypomagnesemia
      • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
      • Slide 114
      • Message for Today
      • Slide 116

        Fluid and electrolyte management are paramount to the care of the surgical patient Changes in both fluid volume and electrolyte composition occur preoperatively intraoperatively and post operatively as well as in response to trauma and sepsis

        Total Body Water

        Who is having higher proportion of body weight as water And Why

        1048699Males or Females

        1048699Lean or Obese

        1048699Young or elderly

        Body Fluid CompartmentsBody Fluid Compartments

        ICFICF55~7555~75

        IntravascularIntravascularplasmaplasma

        X 50~70 X 50~70 lean body weightlean body weight

        ExtravascularExtravascularInterstitial Interstitial

        fluidfluid

        TBWTBW

        ECFECF

        34

        14

        bull Male (55) gt female (45)bull Most concentrated in skeletal musclebull TBW=06xBWbull ICF=04xBWbull ECF=02xBW

        23

        13

        Total body water (TBW)

        bull TBW varies with age gender and body habitus

        bull In adult males= 55 of body weight

        bull In adult female=45 of body weight

        bull In infant = 80 of body weight

        bull Obese patients have less TBW per Kg than lean body

        adult

        1= Intracellular fluid (ICF)=55 TBW or 30-40 BW

        2= Extracellular fluid (ECF) =45TBW or 20 BW

        Interstitial fluid =15 of body weight

        Intravascular fluid or plasma volume

        = 5 of body weight

        Body compartment fluid

        Example men with 70kg TBW= 5570 =385 L

        ICF = 55 385 =212L

        ECF = 45 385=173L

        1 ISF = 15 70 = 105L

        2 PV = 5 70 =35L

        Your User Name

        Fluid compartments

        ICF

        Fluid compartments

        ICF

        ECF

        Interstitial

        Pla

        sma

        Fluid compartments

        ICF

        ECF

        Interstitial

        Pla

        sma

        Fluid compartments

        ICF

        ECF

        Interstitial

        Pla

        sma

        Capillary Membrane

        Fluid compartments

        ICF

        ECF

        Interstitial

        Pla

        sma

        Capillary Membrane

        Fluid compartments

        ICF

        ECF

        Interstitial

        Pla

        sma

        Capillary Membrane Cell Membrane

        Colloid osmotic pressure

        ECF

        Interstitial

        Pla

        sma

        Capillary Membrane

        Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

        Colloid osmotic pressure

        ECF

        Interstitial

        Pla

        sma

        Capillary Membrane

        Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

        Colloid osmotic pressure

        ECF

        Interstitial

        Pla

        sma

        Capillary Membrane

        Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

        The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

        H2O

        H2O

        Colloid osmotic pressure

        ECF

        Interstitial

        Pla

        sma

        Capillary Membrane

        Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

        The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

        This is balanced out by the hydrostatic pressure difference

        H2O

        H2O12080

        H2O

        H2O

        Cell Membrane

        ICF

        Cell Membrane

        Interstitial

        H2O

        H2O

        Cell membrane is freely permeable to H20 but

        Cell Membrane

        ICF

        Cell Membrane

        Na+

        K+

        Interstitial

        H2O

        H2O

        Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

        Cell Membrane

        ICF

        Cell Membrane

        Na-

        K+

        Interstitial

        H2O

        H2O

        Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

        [K+] =4

        Cell Membrane

        ICF

        Cell Membrane

        Na-

        K+

        Interstitial

        H2O

        H2O

        Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

        [K+] =4 [K+] =150

        Cell Membrane

        ICF

        Cell Membrane

        Na-

        K+

        Interstitial

        H2O

        H2O

        Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

        [K+] =4 [K+] =150

        Na+= 144

        Cell Membrane

        ICF

        Cell Membrane

        Na-

        K+

        Interstitial

        H2O

        H2O

        Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

        [K+] =4 [K+] =150

        Na+= 144Na+= 10

        Composition of Fluid Compartments

        CATIONS ANIONS

        Na+ 142 Cl - 103

        HC03- 27

        504mdash

        3 PO4

        ---

        K+ 4 organicCa++ 5 Acid 5

        Mg++ 3 Protein 16

        CATIONS ANIONS

        Na+ 144 Cl - 114

        HC03- 30

        504mdash

        K+ 4 3 PO4

        ---

        organic

        Ca++ 3 Acid 5

        Mg++ 2 Protein 1

        CATIONS ANIONS

        K+ 150 HPO4

        150 504

        mdash

        HCO3- 10

        Mg++ 40 Protein 40

        Na+ 10

        154 mEqL 153 mEqL 153 mEqL154 mEqL

        PLASMA INTERSTITAL FLID

        200 mEqL 200 mEqL

        INTRACELLULAR FLID

        Composition of Body FluidsComposition of Body Fluids

        Ca 2+

        Mg 2+

        K+

        Na+

        Cl-

        PO43-

        Organic anion

        HCO3-

        Protein

        0

        50

        50

        100

        150

        100

        150

        Cations Anions

        EC

        FICF

        Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

        والکترولیت آب تغییرات روی موثر عوامل

        1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

        عمل 2 از قبل والکترولیت آب وضعیت

        اندوکرینوپاتی )3 همراه )بیماریهای

        4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

        Reasons for fluid therapyReasons for fluid therapy

        Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

        bull Correct hypovolaemiaCorrect hypovolaemia

        bull Maintain cardiac outputMaintain cardiac output

        bull Optimise gas exchangeOptimise gas exchange

        bull Replace electrolytes amp waterReplace electrolytes amp water

        bull Maintain urine outputMaintain urine output

        Colloids + RBCs

        Crystalloids

        Identify what is the goal

        Choose fluid which best achieves the goal

        عروقی داخل مایع حجم ارزیابی

        بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

        وریدی محلولهای

        Fluids bull Crystalloids

        bull Colloids

        bull blood

        Which of the following solutions is isotonic

        A D5W

        B 045 saline

        C 09 saline

        D D5 in 09 saline

        SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

        ECFECF 142 4 5 103 27 280-310

        Lactated Lactated RingerrsquosRingerrsquos

        130 4 3 109 28 273

        09 NaCl09 NaCl 154 154 308

        045 045 NaClNaCl

        77 77 154

        D5WD5W

        D5045 D5045 NaClNaCl

        77 77 50 406

        3 NaCl3 NaCl 513 513 1026

        6 6 HetastarchHetastarch

        500 154 154 310

        5 5 AlbuminAlbumin

        250500130-160

        lt25130-160

        330

        25 25 AlbuminAlbumin

        2050100130-160

        lt25130-160

        330

        Common parenteral fluid therapyCommon parenteral fluid therapy

        CrystalloidsCrystalloids

        bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

        Colloid SolutionsColloid Solutions

        bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

        - Haes-steril 10

        الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

        کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

        ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

        osm=273

        09Nacl

        bull Na=154

        bull CL= 154

        کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

        PH=56است

        Postoperative (maintenance)

        045Nacl +5 dextrose +KCL

        Perioperative management of fluid balance include

        1 Preoperative evaluation

        2 Intraoperative maintenance

        3 Replacement of fluid losses

        Preexisting fluid deficits

        bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

        bull Hypotonic fluid (05 saline ) or isotonic crystalloids

        Maintenance requirements

        bull Up to 10 kg = 4cckghr

        bull 11-20kg = add 2cckghr

        bull 21kg and above = add 1cckghr

        bull Insensible losses = 2cckghr

        Surgical fluid losses

        Blood loss (measurement)

        1 Suction container

        2 Surgical sponge

        3 Hct and tachycardia not specific

        4 ABG and UO if hypoperfusion occur

        5 Blood loss=31 with crystalloid

        Other losses (third space loss)

        Third space loss

        1 Minimal (herniorrapy) =2-4cckghr

        2 Moderate (cholecystectomy)=4-6cckghr

        3 Severe (bowel resection) = 6-8cckghr

        Crystalloid solution

        1 The main solutions is either glucose or saline

        2 Hypotonic or isotonic or hypertonic

        3 Safe nontoxic reaction free inexpensive

        4 Complication is edema if large volumes are needed

        5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

        Colloids

        1 Albumin

        2 Hydroxyethyl starch

        3 Dextran

        Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

        factor )These colloid is best avoided in patients with

        coagulopaty

        The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

        1000cc

        500cc

        500cc

        500cc

        200

        600

        1000

        Lactated Ringers

        5 Albumin

        6 Hetastarch

        Whole blood

        Blood volumeInfusion volume

        Colloid versus crystalloid solutions

        Transfusion consideration

        bull HB lt7 mg dl increase CO

        bull Ideal Hb is 7-8 mgdl

        bull In IHD patients or pulmonary disease gt 10 mgdl

        بدن مایعات حجم در اختالل

        1 Fluid volume deficit

        2 Fluid volume excess

        Fluid volume deficit(FVD)

        ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

        کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

        ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

        باشد آن با همراه دیگری اختالل مگر

        DEHYDRATION

        سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

        سلولی خارج حجم کاهش علل

        1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

        2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

        کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

        Signs of HypovolemiaSigns of Hypovolemia

        bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

        Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

        bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

        Signs of HypervolemiaSigns of Hypervolemia

        bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

        Especially when hypo-albuminemia

        Management of Management of HypervolemiaHypervolemia

        bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

        Fluid ManagementFluid Management

        bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

        Electrolyte physiology

        Sodium physiology

        Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

        Normal amount 135-145 meql

        Osmotic Pressure

        Calculated serum osmolality =

        2 sodium+ glucose18 + BUN 28

        Osmolality = 290 mosm

        Concentration

        1Serum sodium concentration2Serum osmolarity

        bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

        drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

        DW5)

        Hypernatremia

        Serum Nagt145mEqL

        - Hypernatremia

        Loss of Free Water

        Gain of sodium in excess of water

        Hypernatremia

        -Hypernatremia Hypo volemic

        Hyper volemic

        Normo volemic

        Hypernatremia

        Volume Status

        Normal

        Nonrenal water loss

        Skin

        Gastrointestinal

        Renal water loss

        Renal disease

        Diuretics

        Diabetes insipidus

        High

        Iatrogenic sodium administration

        Mineralocorticoid excess

        Aldosteronism

        Cushingrsquos disease

        Congenital adrenal

        hyperplasia

        Low

        Nonrenal water loss

        Skin

        Gastrointestinal losses

        Renal water losses

        Renal (tubular) Diuretics

        Osmotic diuretics

        Diabetes insipidus

        Adrenal failure

        Asymptomatic

        Hypernatremia Symptomatic (Nagt160 meqL)

        Clinical Manifestations of Abnormalities in Serum Sodium

        Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

        Body system hypernatremia

        Treatment

        Normal saline in hypovolemic patients

        Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

        saline or entral water)

        Water deficit (L)= times TBW

        The formula used to estimate the amount of water required to correct hypernatremia

        Estimate TBW as 55 of lean body mass in men and 45 in women

        Serum sodium-140

        140

        The rate of fluid administration

        1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

        2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

        Hyponatremia Nalt135mEqL

        Causes

        1 Sodium depletion

        2 Sodium dilution

        bull Incidence = 45

        bull After surgery=1

        bull Mortality = 2 times normal

        Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

        volume deficit

        Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

        Sign and symptoms

        bull CNS symptom when Nalt123 meql

        bull Cardiac symptom when Nalt100 meql

        For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

        Body System Hyponatremia

        central nervous system Headache confusion hyper-or hypoactive deep tendon

        reflexes seizures coma increased intracranial pressure

        Musculoskeletal Weakness fatigue muscle crampstwitching

        Gastrointestinal Anorexia nausea vomiting watery diarrhea

        Cardiovascular Hypertension and bradycardia if significant increases in

        intracranial pressure

        Tissue Lacrimation salivation

        Renal Oliguria

        Clinical Manifestations of Abnormalities in Serum Sodium

        Treatment

        1=Depend on ECF

        2=CNS sign

        Treatment

        1 Asymptomatic increase the sodium level by no more than

        05-1 meqLh to a maximum increase of 12 meqL per day

        2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

        more than 1meqL per hour until the serum Na level reaches 130

        meqL or neurologic symptoms are improved

        Rapid correction of hyponatremia

        Pontine myelinolysis

        Seizures weaknessparesis akinetic

        movements unresponsiveness

        Permanent brain damage

        Death

        Dose

        Na deficit meq =(140- Na meql) TBW

        باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

        شود اصالح آهسته سپس

        Potassium abnormalities

        bull The average dietary intake of potassium 50-100meqd

        bull The average renal excretion of potassium 10-700 meqd

        - 2 of the total body potassium in ECF (45meqL)

        - Factors that influence serum potassium

        1 Surgical stress

        2 Injury

        3 Acidosis

        4 Tissue catabolism

        Hyperkalemia

        The normal range of serum potassium 35-5 meqL

        Etiology of Hyperkalemia

        Increased intake Potassium supplementation

        Blood transfusions

        Endogenous loaddestruction

        hemolysis rhabdomyolysis

        cruch injury gastrointestinal hemorrhage

        Increased release Acidosis

        Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

        Renal insufficiencyfailure

        Clinical manifestation of hyperkalemia

        System hyperkalemia

        Gastrointestinal Nauseavomiting colic diarrhea

        Neuromuscular weakness paralysis respiratory failure

        Cardiovascular Arrhythmia arrest

        ECG changes Peaked T waves (early change)

        Flattened P wave

        Prolonged PR interval (first-degree block)

        Widened QRS complex

        Sine wave formation

        Ventricular fibrillation

        Treatment

        Treatment of symptomatic hyperkalemia

        Potassium removal Kayexalate

        Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

        Rectal administration is 50 g in 200 mL 20 sorbitol

        Dialysis

        Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

        Bicarbonate 1 vial intravenous

        Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

        HypokalemiaEtiology

        inadequate intake

        Dietary potassium-free intravenous fluids potassium-deficient

        total parenteral nutrition

        Excessive potassium excretion

        Hyperaldosteronism

        Medications

        Gastrointestinal losses

        Direct loss of potassium from gastrointestinal fluid (diarrhea)

        Renal loss of potassium (gastric fluid either as vomiting or high

        nasogastric output)

        Intracellular-shift (metabolic alkalosis or insulin therapy)

        Potassium changes associated with alkalosis

        Potassium decrease by 03 meqL for every 01

        increase in PH above normal

        Magnesium Depletion

        (drug induced amphotericin amioglycosides cisplatin)

        Renal potassium wastage

        Hypokalemia

        Magnesium Depletion

        (drug induced amphotericin amioglycosides cisplatin)

        Renal potassium wastage

        Hypokalemia

        Clinical Manifestation of Abnormalities in potassium

        System hypokalemia

        Gastrointestinal Ileus constipation

        Neuromuscular Decreased reflexes fatigue weakness

        paralysis

        Cardiovascular Arrest

        ECG changes U-waves

        T-wave flattening

        ST-segment changes

        Arrhythmias

        Treatment

        Potassium

        Serum potassium level lt40 mEqL

        Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

        times 1 doses

        Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

        Symptomatic KC1 20 mEq IV q1h times 4 doses

        Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

        asymptomatic replace as per above protocol

        Electrolyte Replacement Therapy Protocol

        bull Oral repletion for mild and asymptomatic hypokalemia

        bull IV repletion for severe and symptomatic hypokalemia

        Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

        ( دندانها( ndash استخوانbull كلسيم نقش

        عصبي 1 ايمپالسهاي )NMJ(انتقال

        صاف 2 عضالت انقباض

        هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

        انعقاد 4

        یونیزه Calt45 meql هيپوكلسمي

        عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

        ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

        میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

        ( شود می پیوند شده

        هیپوکلسمی عالئم

        رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

        سایرعالئم

        قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

        درمان

        ای bull زمینه علت کردن طرف بروریدی bull کلسیم

        Cagt55meql هيپركلسمي

        هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

        عالئم

        bullGI

        bullCardiovascular bullRenal (polyuria)

        bullCNS

        قلبی عالئم

        bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

        QRS شدن )Q-Tوكوتاه

        درمان

        ایزوتونیک 1 نمکی محلول انفوزیون

        الزیکس2

        تونین 3 کلسی

        کورتون4

        دیالیز5

        Magnesium Abnormalities

        Normal dietary intake 20meq (240mg)

        Excretion in both the feces and urine

        Normal serum level 19-25 mgdL

        منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

        تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

        bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

        Hypermagnesemia

        Etiology

        1 Impaired renal function

        2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

        Clinical manifestation hypermanesemia

        System hypermanesemia

        Gastrointestinal Nauseavomiting

        Neuromuscular weakness lethargy Decreased

        reflexes

        Cardiovascular Hypotension arrest

        ECG changes Increased PR interval

        Widened QRS complex

        Elevated T waves

        Treatment

        1 Withhold exogenous sources of magnesium

        2 Correct volume deficit

        3 Correct acidosis if present

        4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

        5 Dialysis (if elevated levels or symptoms persist)

        عالئم

        bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

        meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

        meqL

        Hypomagnesemia

        Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

        homeostasis

        Etiology

        1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

        inadequate supplementation of magnesium)

        2 Increased renal excretion (alcohol most diuretics and amphotericin B)

        3 GI losses (diarrhea)

        4 Malabsorption

        5 Acute pancreatitis

        6 Diabetic ketoacidosis

        7 Primary aldosteronism

        Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

        1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

        2 Delirium and seizures in severe deficiency

        3 ECG changes Prolonged QT and PR interval

        ST-segment depression

        Flattening or inversion of P waves

        Torsades de pointes

        Arrhythmia

        Treatment

        1 For asymptomatic and mild hypomagnesemia administer oral mg

        2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

        Message for Today

        ICF

        Interstitial

        Pla

        sma

        5 Dex

        bull Do not reccussitate sick patients with any Dextrose solution

        • Fluid and Electrolyte Management of the Surgical Patient
        • Slide 2
        • Slide 3
        • Slide 4
        • Total Body Water
        • Body Fluid Compartments
        • Total body water (TBW)
        • Body compartment fluid
        • Example men with 70kg
        • Fluid compartments
        • Slide 11
        • Slide 12
        • Slide 13
        • Slide 14
        • Slide 15
        • Colloid osmotic pressure
        • Slide 17
        • Slide 18
        • Slide 19
        • Cell Membrane
        • Slide 21
        • Slide 22
        • Slide 23
        • Slide 24
        • Slide 25
        • Composition of Fluid Compartments
        • Composition of Body Fluids
        • عوامل موثر روی تغییرات آب والکترولیت
        • Reasons for fluid therapy
        • ارزیابی حجم مایع داخل عروقی
        • محلولهای وریدی
        • Fluids
        • Slide 33
        • Slide 34
        • Slide 35
        • Crystalloids
        • Colloid Solutions
        • رینگر لاکتات
        • 09Nacl
        • Postoperative (maintenance)
        • Slide 41
        • Preexisting fluid deficits
        • Maintenance requirements
        • Surgical fluid losses
        • Third space loss
        • Crystalloid solution
        • Colloids
        • Complications
        • The Influence of Colloid amp Crystalloid on Blood Volume
        • Colloid versus crystalloid solutions
        • Transfusion consideration
        • اختلال در حجم مایعات بدن
        • Fluid volume deficit (FVD)
        • DEHYDRATION
        • علل کاهش حجم خارج سلولی
        • Signs of Hypovolemia
        • Clinical Diagnosis of Hypovolemia
        • Signs of Hypervolemia
        • Management of Hypervolemia
        • Fluid Management
        • Electrolyte physiology
        • Sodium physiology
        • Osmotic Pressure
        • Concentration
        • Hypernatremia
        • - Hypernatremia
        • Slide 67
        • Slide 68
        • Clinical Manifestations of Abnormalities in Serum Sodium
        • Treatment
        • Water deficit (L)= times TBW
        • The rate of fluid administration
        • Hyponatremia Nalt135mEqL
        • Slide 74
        • Sodium depletion
        • Sodium dilution
        • Sign and symptoms
        • Slide 78
        • Treatment
        • Slide 80
        • Slide 81
        • Dose
        • Potassium abnormalities
        • Hyperkalemia
        • Clinical manifestation of hyperkalemia
        • Slide 86
        • Slide 87
        • Hypokalemia
        • Potassium changes associated with alkalosis
        • Slide 90
        • Clinical Manifestation of Abnormalities in potassium
        • Slide 92
        • Calcium
        • هيپوكلسمي یونیزه Calt45 meql
        • علائم هیپوکلسمی
        • Slide 96
        • Slide 97
        • Slide 98
        • Slide 99
        • سایرعلائم
        • درمان
        • هيپركلسمي Cagt55meql
        • علائم
        • علائم قلبی
        • Slide 105
        • Magnesium Abnormalities
        • منیزیوم
        • Hypermagnesemia
        • Clinical manifestation hypermanesemia
        • Slide 110
        • Slide 111
        • Hypomagnesemia
        • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
        • Slide 114
        • Message for Today
        • Slide 116

          Total Body Water

          Who is having higher proportion of body weight as water And Why

          1048699Males or Females

          1048699Lean or Obese

          1048699Young or elderly

          Body Fluid CompartmentsBody Fluid Compartments

          ICFICF55~7555~75

          IntravascularIntravascularplasmaplasma

          X 50~70 X 50~70 lean body weightlean body weight

          ExtravascularExtravascularInterstitial Interstitial

          fluidfluid

          TBWTBW

          ECFECF

          34

          14

          bull Male (55) gt female (45)bull Most concentrated in skeletal musclebull TBW=06xBWbull ICF=04xBWbull ECF=02xBW

          23

          13

          Total body water (TBW)

          bull TBW varies with age gender and body habitus

          bull In adult males= 55 of body weight

          bull In adult female=45 of body weight

          bull In infant = 80 of body weight

          bull Obese patients have less TBW per Kg than lean body

          adult

          1= Intracellular fluid (ICF)=55 TBW or 30-40 BW

          2= Extracellular fluid (ECF) =45TBW or 20 BW

          Interstitial fluid =15 of body weight

          Intravascular fluid or plasma volume

          = 5 of body weight

          Body compartment fluid

          Example men with 70kg TBW= 5570 =385 L

          ICF = 55 385 =212L

          ECF = 45 385=173L

          1 ISF = 15 70 = 105L

          2 PV = 5 70 =35L

          Your User Name

          Fluid compartments

          ICF

          Fluid compartments

          ICF

          ECF

          Interstitial

          Pla

          sma

          Fluid compartments

          ICF

          ECF

          Interstitial

          Pla

          sma

          Fluid compartments

          ICF

          ECF

          Interstitial

          Pla

          sma

          Capillary Membrane

          Fluid compartments

          ICF

          ECF

          Interstitial

          Pla

          sma

          Capillary Membrane

          Fluid compartments

          ICF

          ECF

          Interstitial

          Pla

          sma

          Capillary Membrane Cell Membrane

          Colloid osmotic pressure

          ECF

          Interstitial

          Pla

          sma

          Capillary Membrane

          Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

          Colloid osmotic pressure

          ECF

          Interstitial

          Pla

          sma

          Capillary Membrane

          Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

          Colloid osmotic pressure

          ECF

          Interstitial

          Pla

          sma

          Capillary Membrane

          Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

          The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

          H2O

          H2O

          Colloid osmotic pressure

          ECF

          Interstitial

          Pla

          sma

          Capillary Membrane

          Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

          The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

          This is balanced out by the hydrostatic pressure difference

          H2O

          H2O12080

          H2O

          H2O

          Cell Membrane

          ICF

          Cell Membrane

          Interstitial

          H2O

          H2O

          Cell membrane is freely permeable to H20 but

          Cell Membrane

          ICF

          Cell Membrane

          Na+

          K+

          Interstitial

          H2O

          H2O

          Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

          Cell Membrane

          ICF

          Cell Membrane

          Na-

          K+

          Interstitial

          H2O

          H2O

          Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

          [K+] =4

          Cell Membrane

          ICF

          Cell Membrane

          Na-

          K+

          Interstitial

          H2O

          H2O

          Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

          [K+] =4 [K+] =150

          Cell Membrane

          ICF

          Cell Membrane

          Na-

          K+

          Interstitial

          H2O

          H2O

          Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

          [K+] =4 [K+] =150

          Na+= 144

          Cell Membrane

          ICF

          Cell Membrane

          Na-

          K+

          Interstitial

          H2O

          H2O

          Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

          [K+] =4 [K+] =150

          Na+= 144Na+= 10

          Composition of Fluid Compartments

          CATIONS ANIONS

          Na+ 142 Cl - 103

          HC03- 27

          504mdash

          3 PO4

          ---

          K+ 4 organicCa++ 5 Acid 5

          Mg++ 3 Protein 16

          CATIONS ANIONS

          Na+ 144 Cl - 114

          HC03- 30

          504mdash

          K+ 4 3 PO4

          ---

          organic

          Ca++ 3 Acid 5

          Mg++ 2 Protein 1

          CATIONS ANIONS

          K+ 150 HPO4

          150 504

          mdash

          HCO3- 10

          Mg++ 40 Protein 40

          Na+ 10

          154 mEqL 153 mEqL 153 mEqL154 mEqL

          PLASMA INTERSTITAL FLID

          200 mEqL 200 mEqL

          INTRACELLULAR FLID

          Composition of Body FluidsComposition of Body Fluids

          Ca 2+

          Mg 2+

          K+

          Na+

          Cl-

          PO43-

          Organic anion

          HCO3-

          Protein

          0

          50

          50

          100

          150

          100

          150

          Cations Anions

          EC

          FICF

          Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

          والکترولیت آب تغییرات روی موثر عوامل

          1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

          عمل 2 از قبل والکترولیت آب وضعیت

          اندوکرینوپاتی )3 همراه )بیماریهای

          4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

          Reasons for fluid therapyReasons for fluid therapy

          Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

          bull Correct hypovolaemiaCorrect hypovolaemia

          bull Maintain cardiac outputMaintain cardiac output

          bull Optimise gas exchangeOptimise gas exchange

          bull Replace electrolytes amp waterReplace electrolytes amp water

          bull Maintain urine outputMaintain urine output

          Colloids + RBCs

          Crystalloids

          Identify what is the goal

          Choose fluid which best achieves the goal

          عروقی داخل مایع حجم ارزیابی

          بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

          وریدی محلولهای

          Fluids bull Crystalloids

          bull Colloids

          bull blood

          Which of the following solutions is isotonic

          A D5W

          B 045 saline

          C 09 saline

          D D5 in 09 saline

          SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

          ECFECF 142 4 5 103 27 280-310

          Lactated Lactated RingerrsquosRingerrsquos

          130 4 3 109 28 273

          09 NaCl09 NaCl 154 154 308

          045 045 NaClNaCl

          77 77 154

          D5WD5W

          D5045 D5045 NaClNaCl

          77 77 50 406

          3 NaCl3 NaCl 513 513 1026

          6 6 HetastarchHetastarch

          500 154 154 310

          5 5 AlbuminAlbumin

          250500130-160

          lt25130-160

          330

          25 25 AlbuminAlbumin

          2050100130-160

          lt25130-160

          330

          Common parenteral fluid therapyCommon parenteral fluid therapy

          CrystalloidsCrystalloids

          bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

          Colloid SolutionsColloid Solutions

          bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

          - Haes-steril 10

          الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

          کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

          ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

          osm=273

          09Nacl

          bull Na=154

          bull CL= 154

          کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

          PH=56است

          Postoperative (maintenance)

          045Nacl +5 dextrose +KCL

          Perioperative management of fluid balance include

          1 Preoperative evaluation

          2 Intraoperative maintenance

          3 Replacement of fluid losses

          Preexisting fluid deficits

          bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

          bull Hypotonic fluid (05 saline ) or isotonic crystalloids

          Maintenance requirements

          bull Up to 10 kg = 4cckghr

          bull 11-20kg = add 2cckghr

          bull 21kg and above = add 1cckghr

          bull Insensible losses = 2cckghr

          Surgical fluid losses

          Blood loss (measurement)

          1 Suction container

          2 Surgical sponge

          3 Hct and tachycardia not specific

          4 ABG and UO if hypoperfusion occur

          5 Blood loss=31 with crystalloid

          Other losses (third space loss)

          Third space loss

          1 Minimal (herniorrapy) =2-4cckghr

          2 Moderate (cholecystectomy)=4-6cckghr

          3 Severe (bowel resection) = 6-8cckghr

          Crystalloid solution

          1 The main solutions is either glucose or saline

          2 Hypotonic or isotonic or hypertonic

          3 Safe nontoxic reaction free inexpensive

          4 Complication is edema if large volumes are needed

          5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

          Colloids

          1 Albumin

          2 Hydroxyethyl starch

          3 Dextran

          Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

          factor )These colloid is best avoided in patients with

          coagulopaty

          The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

          1000cc

          500cc

          500cc

          500cc

          200

          600

          1000

          Lactated Ringers

          5 Albumin

          6 Hetastarch

          Whole blood

          Blood volumeInfusion volume

          Colloid versus crystalloid solutions

          Transfusion consideration

          bull HB lt7 mg dl increase CO

          bull Ideal Hb is 7-8 mgdl

          bull In IHD patients or pulmonary disease gt 10 mgdl

          بدن مایعات حجم در اختالل

          1 Fluid volume deficit

          2 Fluid volume excess

          Fluid volume deficit(FVD)

          ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

          کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

          ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

          باشد آن با همراه دیگری اختالل مگر

          DEHYDRATION

          سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

          سلولی خارج حجم کاهش علل

          1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

          2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

          کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

          Signs of HypovolemiaSigns of Hypovolemia

          bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

          Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

          bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

          Signs of HypervolemiaSigns of Hypervolemia

          bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

          Especially when hypo-albuminemia

          Management of Management of HypervolemiaHypervolemia

          bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

          Fluid ManagementFluid Management

          bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

          Electrolyte physiology

          Sodium physiology

          Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

          Normal amount 135-145 meql

          Osmotic Pressure

          Calculated serum osmolality =

          2 sodium+ glucose18 + BUN 28

          Osmolality = 290 mosm

          Concentration

          1Serum sodium concentration2Serum osmolarity

          bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

          drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

          DW5)

          Hypernatremia

          Serum Nagt145mEqL

          - Hypernatremia

          Loss of Free Water

          Gain of sodium in excess of water

          Hypernatremia

          -Hypernatremia Hypo volemic

          Hyper volemic

          Normo volemic

          Hypernatremia

          Volume Status

          Normal

          Nonrenal water loss

          Skin

          Gastrointestinal

          Renal water loss

          Renal disease

          Diuretics

          Diabetes insipidus

          High

          Iatrogenic sodium administration

          Mineralocorticoid excess

          Aldosteronism

          Cushingrsquos disease

          Congenital adrenal

          hyperplasia

          Low

          Nonrenal water loss

          Skin

          Gastrointestinal losses

          Renal water losses

          Renal (tubular) Diuretics

          Osmotic diuretics

          Diabetes insipidus

          Adrenal failure

          Asymptomatic

          Hypernatremia Symptomatic (Nagt160 meqL)

          Clinical Manifestations of Abnormalities in Serum Sodium

          Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

          Body system hypernatremia

          Treatment

          Normal saline in hypovolemic patients

          Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

          saline or entral water)

          Water deficit (L)= times TBW

          The formula used to estimate the amount of water required to correct hypernatremia

          Estimate TBW as 55 of lean body mass in men and 45 in women

          Serum sodium-140

          140

          The rate of fluid administration

          1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

          2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

          Hyponatremia Nalt135mEqL

          Causes

          1 Sodium depletion

          2 Sodium dilution

          bull Incidence = 45

          bull After surgery=1

          bull Mortality = 2 times normal

          Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

          volume deficit

          Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

          Sign and symptoms

          bull CNS symptom when Nalt123 meql

          bull Cardiac symptom when Nalt100 meql

          For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

          Body System Hyponatremia

          central nervous system Headache confusion hyper-or hypoactive deep tendon

          reflexes seizures coma increased intracranial pressure

          Musculoskeletal Weakness fatigue muscle crampstwitching

          Gastrointestinal Anorexia nausea vomiting watery diarrhea

          Cardiovascular Hypertension and bradycardia if significant increases in

          intracranial pressure

          Tissue Lacrimation salivation

          Renal Oliguria

          Clinical Manifestations of Abnormalities in Serum Sodium

          Treatment

          1=Depend on ECF

          2=CNS sign

          Treatment

          1 Asymptomatic increase the sodium level by no more than

          05-1 meqLh to a maximum increase of 12 meqL per day

          2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

          more than 1meqL per hour until the serum Na level reaches 130

          meqL or neurologic symptoms are improved

          Rapid correction of hyponatremia

          Pontine myelinolysis

          Seizures weaknessparesis akinetic

          movements unresponsiveness

          Permanent brain damage

          Death

          Dose

          Na deficit meq =(140- Na meql) TBW

          باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

          شود اصالح آهسته سپس

          Potassium abnormalities

          bull The average dietary intake of potassium 50-100meqd

          bull The average renal excretion of potassium 10-700 meqd

          - 2 of the total body potassium in ECF (45meqL)

          - Factors that influence serum potassium

          1 Surgical stress

          2 Injury

          3 Acidosis

          4 Tissue catabolism

          Hyperkalemia

          The normal range of serum potassium 35-5 meqL

          Etiology of Hyperkalemia

          Increased intake Potassium supplementation

          Blood transfusions

          Endogenous loaddestruction

          hemolysis rhabdomyolysis

          cruch injury gastrointestinal hemorrhage

          Increased release Acidosis

          Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

          Renal insufficiencyfailure

          Clinical manifestation of hyperkalemia

          System hyperkalemia

          Gastrointestinal Nauseavomiting colic diarrhea

          Neuromuscular weakness paralysis respiratory failure

          Cardiovascular Arrhythmia arrest

          ECG changes Peaked T waves (early change)

          Flattened P wave

          Prolonged PR interval (first-degree block)

          Widened QRS complex

          Sine wave formation

          Ventricular fibrillation

          Treatment

          Treatment of symptomatic hyperkalemia

          Potassium removal Kayexalate

          Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

          Rectal administration is 50 g in 200 mL 20 sorbitol

          Dialysis

          Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

          Bicarbonate 1 vial intravenous

          Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

          HypokalemiaEtiology

          inadequate intake

          Dietary potassium-free intravenous fluids potassium-deficient

          total parenteral nutrition

          Excessive potassium excretion

          Hyperaldosteronism

          Medications

          Gastrointestinal losses

          Direct loss of potassium from gastrointestinal fluid (diarrhea)

          Renal loss of potassium (gastric fluid either as vomiting or high

          nasogastric output)

          Intracellular-shift (metabolic alkalosis or insulin therapy)

          Potassium changes associated with alkalosis

          Potassium decrease by 03 meqL for every 01

          increase in PH above normal

          Magnesium Depletion

          (drug induced amphotericin amioglycosides cisplatin)

          Renal potassium wastage

          Hypokalemia

          Magnesium Depletion

          (drug induced amphotericin amioglycosides cisplatin)

          Renal potassium wastage

          Hypokalemia

          Clinical Manifestation of Abnormalities in potassium

          System hypokalemia

          Gastrointestinal Ileus constipation

          Neuromuscular Decreased reflexes fatigue weakness

          paralysis

          Cardiovascular Arrest

          ECG changes U-waves

          T-wave flattening

          ST-segment changes

          Arrhythmias

          Treatment

          Potassium

          Serum potassium level lt40 mEqL

          Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

          times 1 doses

          Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

          Symptomatic KC1 20 mEq IV q1h times 4 doses

          Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

          asymptomatic replace as per above protocol

          Electrolyte Replacement Therapy Protocol

          bull Oral repletion for mild and asymptomatic hypokalemia

          bull IV repletion for severe and symptomatic hypokalemia

          Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

          ( دندانها( ndash استخوانbull كلسيم نقش

          عصبي 1 ايمپالسهاي )NMJ(انتقال

          صاف 2 عضالت انقباض

          هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

          انعقاد 4

          یونیزه Calt45 meql هيپوكلسمي

          عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

          ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

          میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

          ( شود می پیوند شده

          هیپوکلسمی عالئم

          رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

          سایرعالئم

          قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

          درمان

          ای bull زمینه علت کردن طرف بروریدی bull کلسیم

          Cagt55meql هيپركلسمي

          هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

          عالئم

          bullGI

          bullCardiovascular bullRenal (polyuria)

          bullCNS

          قلبی عالئم

          bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

          QRS شدن )Q-Tوكوتاه

          درمان

          ایزوتونیک 1 نمکی محلول انفوزیون

          الزیکس2

          تونین 3 کلسی

          کورتون4

          دیالیز5

          Magnesium Abnormalities

          Normal dietary intake 20meq (240mg)

          Excretion in both the feces and urine

          Normal serum level 19-25 mgdL

          منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

          تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

          bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

          Hypermagnesemia

          Etiology

          1 Impaired renal function

          2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

          Clinical manifestation hypermanesemia

          System hypermanesemia

          Gastrointestinal Nauseavomiting

          Neuromuscular weakness lethargy Decreased

          reflexes

          Cardiovascular Hypotension arrest

          ECG changes Increased PR interval

          Widened QRS complex

          Elevated T waves

          Treatment

          1 Withhold exogenous sources of magnesium

          2 Correct volume deficit

          3 Correct acidosis if present

          4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

          5 Dialysis (if elevated levels or symptoms persist)

          عالئم

          bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

          meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

          meqL

          Hypomagnesemia

          Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

          homeostasis

          Etiology

          1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

          inadequate supplementation of magnesium)

          2 Increased renal excretion (alcohol most diuretics and amphotericin B)

          3 GI losses (diarrhea)

          4 Malabsorption

          5 Acute pancreatitis

          6 Diabetic ketoacidosis

          7 Primary aldosteronism

          Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

          1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

          2 Delirium and seizures in severe deficiency

          3 ECG changes Prolonged QT and PR interval

          ST-segment depression

          Flattening or inversion of P waves

          Torsades de pointes

          Arrhythmia

          Treatment

          1 For asymptomatic and mild hypomagnesemia administer oral mg

          2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

          Message for Today

          ICF

          Interstitial

          Pla

          sma

          5 Dex

          bull Do not reccussitate sick patients with any Dextrose solution

          • Fluid and Electrolyte Management of the Surgical Patient
          • Slide 2
          • Slide 3
          • Slide 4
          • Total Body Water
          • Body Fluid Compartments
          • Total body water (TBW)
          • Body compartment fluid
          • Example men with 70kg
          • Fluid compartments
          • Slide 11
          • Slide 12
          • Slide 13
          • Slide 14
          • Slide 15
          • Colloid osmotic pressure
          • Slide 17
          • Slide 18
          • Slide 19
          • Cell Membrane
          • Slide 21
          • Slide 22
          • Slide 23
          • Slide 24
          • Slide 25
          • Composition of Fluid Compartments
          • Composition of Body Fluids
          • عوامل موثر روی تغییرات آب والکترولیت
          • Reasons for fluid therapy
          • ارزیابی حجم مایع داخل عروقی
          • محلولهای وریدی
          • Fluids
          • Slide 33
          • Slide 34
          • Slide 35
          • Crystalloids
          • Colloid Solutions
          • رینگر لاکتات
          • 09Nacl
          • Postoperative (maintenance)
          • Slide 41
          • Preexisting fluid deficits
          • Maintenance requirements
          • Surgical fluid losses
          • Third space loss
          • Crystalloid solution
          • Colloids
          • Complications
          • The Influence of Colloid amp Crystalloid on Blood Volume
          • Colloid versus crystalloid solutions
          • Transfusion consideration
          • اختلال در حجم مایعات بدن
          • Fluid volume deficit (FVD)
          • DEHYDRATION
          • علل کاهش حجم خارج سلولی
          • Signs of Hypovolemia
          • Clinical Diagnosis of Hypovolemia
          • Signs of Hypervolemia
          • Management of Hypervolemia
          • Fluid Management
          • Electrolyte physiology
          • Sodium physiology
          • Osmotic Pressure
          • Concentration
          • Hypernatremia
          • - Hypernatremia
          • Slide 67
          • Slide 68
          • Clinical Manifestations of Abnormalities in Serum Sodium
          • Treatment
          • Water deficit (L)= times TBW
          • The rate of fluid administration
          • Hyponatremia Nalt135mEqL
          • Slide 74
          • Sodium depletion
          • Sodium dilution
          • Sign and symptoms
          • Slide 78
          • Treatment
          • Slide 80
          • Slide 81
          • Dose
          • Potassium abnormalities
          • Hyperkalemia
          • Clinical manifestation of hyperkalemia
          • Slide 86
          • Slide 87
          • Hypokalemia
          • Potassium changes associated with alkalosis
          • Slide 90
          • Clinical Manifestation of Abnormalities in potassium
          • Slide 92
          • Calcium
          • هيپوكلسمي یونیزه Calt45 meql
          • علائم هیپوکلسمی
          • Slide 96
          • Slide 97
          • Slide 98
          • Slide 99
          • سایرعلائم
          • درمان
          • هيپركلسمي Cagt55meql
          • علائم
          • علائم قلبی
          • Slide 105
          • Magnesium Abnormalities
          • منیزیوم
          • Hypermagnesemia
          • Clinical manifestation hypermanesemia
          • Slide 110
          • Slide 111
          • Hypomagnesemia
          • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
          • Slide 114
          • Message for Today
          • Slide 116

            Body Fluid CompartmentsBody Fluid Compartments

            ICFICF55~7555~75

            IntravascularIntravascularplasmaplasma

            X 50~70 X 50~70 lean body weightlean body weight

            ExtravascularExtravascularInterstitial Interstitial

            fluidfluid

            TBWTBW

            ECFECF

            34

            14

            bull Male (55) gt female (45)bull Most concentrated in skeletal musclebull TBW=06xBWbull ICF=04xBWbull ECF=02xBW

            23

            13

            Total body water (TBW)

            bull TBW varies with age gender and body habitus

            bull In adult males= 55 of body weight

            bull In adult female=45 of body weight

            bull In infant = 80 of body weight

            bull Obese patients have less TBW per Kg than lean body

            adult

            1= Intracellular fluid (ICF)=55 TBW or 30-40 BW

            2= Extracellular fluid (ECF) =45TBW or 20 BW

            Interstitial fluid =15 of body weight

            Intravascular fluid or plasma volume

            = 5 of body weight

            Body compartment fluid

            Example men with 70kg TBW= 5570 =385 L

            ICF = 55 385 =212L

            ECF = 45 385=173L

            1 ISF = 15 70 = 105L

            2 PV = 5 70 =35L

            Your User Name

            Fluid compartments

            ICF

            Fluid compartments

            ICF

            ECF

            Interstitial

            Pla

            sma

            Fluid compartments

            ICF

            ECF

            Interstitial

            Pla

            sma

            Fluid compartments

            ICF

            ECF

            Interstitial

            Pla

            sma

            Capillary Membrane

            Fluid compartments

            ICF

            ECF

            Interstitial

            Pla

            sma

            Capillary Membrane

            Fluid compartments

            ICF

            ECF

            Interstitial

            Pla

            sma

            Capillary Membrane Cell Membrane

            Colloid osmotic pressure

            ECF

            Interstitial

            Pla

            sma

            Capillary Membrane

            Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

            Colloid osmotic pressure

            ECF

            Interstitial

            Pla

            sma

            Capillary Membrane

            Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

            Colloid osmotic pressure

            ECF

            Interstitial

            Pla

            sma

            Capillary Membrane

            Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

            The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

            H2O

            H2O

            Colloid osmotic pressure

            ECF

            Interstitial

            Pla

            sma

            Capillary Membrane

            Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

            The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

            This is balanced out by the hydrostatic pressure difference

            H2O

            H2O12080

            H2O

            H2O

            Cell Membrane

            ICF

            Cell Membrane

            Interstitial

            H2O

            H2O

            Cell membrane is freely permeable to H20 but

            Cell Membrane

            ICF

            Cell Membrane

            Na+

            K+

            Interstitial

            H2O

            H2O

            Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

            Cell Membrane

            ICF

            Cell Membrane

            Na-

            K+

            Interstitial

            H2O

            H2O

            Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

            [K+] =4

            Cell Membrane

            ICF

            Cell Membrane

            Na-

            K+

            Interstitial

            H2O

            H2O

            Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

            [K+] =4 [K+] =150

            Cell Membrane

            ICF

            Cell Membrane

            Na-

            K+

            Interstitial

            H2O

            H2O

            Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

            [K+] =4 [K+] =150

            Na+= 144

            Cell Membrane

            ICF

            Cell Membrane

            Na-

            K+

            Interstitial

            H2O

            H2O

            Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

            [K+] =4 [K+] =150

            Na+= 144Na+= 10

            Composition of Fluid Compartments

            CATIONS ANIONS

            Na+ 142 Cl - 103

            HC03- 27

            504mdash

            3 PO4

            ---

            K+ 4 organicCa++ 5 Acid 5

            Mg++ 3 Protein 16

            CATIONS ANIONS

            Na+ 144 Cl - 114

            HC03- 30

            504mdash

            K+ 4 3 PO4

            ---

            organic

            Ca++ 3 Acid 5

            Mg++ 2 Protein 1

            CATIONS ANIONS

            K+ 150 HPO4

            150 504

            mdash

            HCO3- 10

            Mg++ 40 Protein 40

            Na+ 10

            154 mEqL 153 mEqL 153 mEqL154 mEqL

            PLASMA INTERSTITAL FLID

            200 mEqL 200 mEqL

            INTRACELLULAR FLID

            Composition of Body FluidsComposition of Body Fluids

            Ca 2+

            Mg 2+

            K+

            Na+

            Cl-

            PO43-

            Organic anion

            HCO3-

            Protein

            0

            50

            50

            100

            150

            100

            150

            Cations Anions

            EC

            FICF

            Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

            والکترولیت آب تغییرات روی موثر عوامل

            1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

            عمل 2 از قبل والکترولیت آب وضعیت

            اندوکرینوپاتی )3 همراه )بیماریهای

            4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

            Reasons for fluid therapyReasons for fluid therapy

            Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

            bull Correct hypovolaemiaCorrect hypovolaemia

            bull Maintain cardiac outputMaintain cardiac output

            bull Optimise gas exchangeOptimise gas exchange

            bull Replace electrolytes amp waterReplace electrolytes amp water

            bull Maintain urine outputMaintain urine output

            Colloids + RBCs

            Crystalloids

            Identify what is the goal

            Choose fluid which best achieves the goal

            عروقی داخل مایع حجم ارزیابی

            بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

            وریدی محلولهای

            Fluids bull Crystalloids

            bull Colloids

            bull blood

            Which of the following solutions is isotonic

            A D5W

            B 045 saline

            C 09 saline

            D D5 in 09 saline

            SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

            ECFECF 142 4 5 103 27 280-310

            Lactated Lactated RingerrsquosRingerrsquos

            130 4 3 109 28 273

            09 NaCl09 NaCl 154 154 308

            045 045 NaClNaCl

            77 77 154

            D5WD5W

            D5045 D5045 NaClNaCl

            77 77 50 406

            3 NaCl3 NaCl 513 513 1026

            6 6 HetastarchHetastarch

            500 154 154 310

            5 5 AlbuminAlbumin

            250500130-160

            lt25130-160

            330

            25 25 AlbuminAlbumin

            2050100130-160

            lt25130-160

            330

            Common parenteral fluid therapyCommon parenteral fluid therapy

            CrystalloidsCrystalloids

            bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

            Colloid SolutionsColloid Solutions

            bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

            - Haes-steril 10

            الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

            کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

            ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

            osm=273

            09Nacl

            bull Na=154

            bull CL= 154

            کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

            PH=56است

            Postoperative (maintenance)

            045Nacl +5 dextrose +KCL

            Perioperative management of fluid balance include

            1 Preoperative evaluation

            2 Intraoperative maintenance

            3 Replacement of fluid losses

            Preexisting fluid deficits

            bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

            bull Hypotonic fluid (05 saline ) or isotonic crystalloids

            Maintenance requirements

            bull Up to 10 kg = 4cckghr

            bull 11-20kg = add 2cckghr

            bull 21kg and above = add 1cckghr

            bull Insensible losses = 2cckghr

            Surgical fluid losses

            Blood loss (measurement)

            1 Suction container

            2 Surgical sponge

            3 Hct and tachycardia not specific

            4 ABG and UO if hypoperfusion occur

            5 Blood loss=31 with crystalloid

            Other losses (third space loss)

            Third space loss

            1 Minimal (herniorrapy) =2-4cckghr

            2 Moderate (cholecystectomy)=4-6cckghr

            3 Severe (bowel resection) = 6-8cckghr

            Crystalloid solution

            1 The main solutions is either glucose or saline

            2 Hypotonic or isotonic or hypertonic

            3 Safe nontoxic reaction free inexpensive

            4 Complication is edema if large volumes are needed

            5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

            Colloids

            1 Albumin

            2 Hydroxyethyl starch

            3 Dextran

            Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

            factor )These colloid is best avoided in patients with

            coagulopaty

            The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

            1000cc

            500cc

            500cc

            500cc

            200

            600

            1000

            Lactated Ringers

            5 Albumin

            6 Hetastarch

            Whole blood

            Blood volumeInfusion volume

            Colloid versus crystalloid solutions

            Transfusion consideration

            bull HB lt7 mg dl increase CO

            bull Ideal Hb is 7-8 mgdl

            bull In IHD patients or pulmonary disease gt 10 mgdl

            بدن مایعات حجم در اختالل

            1 Fluid volume deficit

            2 Fluid volume excess

            Fluid volume deficit(FVD)

            ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

            کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

            ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

            باشد آن با همراه دیگری اختالل مگر

            DEHYDRATION

            سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

            سلولی خارج حجم کاهش علل

            1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

            2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

            کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

            Signs of HypovolemiaSigns of Hypovolemia

            bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

            Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

            bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

            Signs of HypervolemiaSigns of Hypervolemia

            bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

            Especially when hypo-albuminemia

            Management of Management of HypervolemiaHypervolemia

            bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

            Fluid ManagementFluid Management

            bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

            Electrolyte physiology

            Sodium physiology

            Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

            Normal amount 135-145 meql

            Osmotic Pressure

            Calculated serum osmolality =

            2 sodium+ glucose18 + BUN 28

            Osmolality = 290 mosm

            Concentration

            1Serum sodium concentration2Serum osmolarity

            bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

            drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

            DW5)

            Hypernatremia

            Serum Nagt145mEqL

            - Hypernatremia

            Loss of Free Water

            Gain of sodium in excess of water

            Hypernatremia

            -Hypernatremia Hypo volemic

            Hyper volemic

            Normo volemic

            Hypernatremia

            Volume Status

            Normal

            Nonrenal water loss

            Skin

            Gastrointestinal

            Renal water loss

            Renal disease

            Diuretics

            Diabetes insipidus

            High

            Iatrogenic sodium administration

            Mineralocorticoid excess

            Aldosteronism

            Cushingrsquos disease

            Congenital adrenal

            hyperplasia

            Low

            Nonrenal water loss

            Skin

            Gastrointestinal losses

            Renal water losses

            Renal (tubular) Diuretics

            Osmotic diuretics

            Diabetes insipidus

            Adrenal failure

            Asymptomatic

            Hypernatremia Symptomatic (Nagt160 meqL)

            Clinical Manifestations of Abnormalities in Serum Sodium

            Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

            Body system hypernatremia

            Treatment

            Normal saline in hypovolemic patients

            Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

            saline or entral water)

            Water deficit (L)= times TBW

            The formula used to estimate the amount of water required to correct hypernatremia

            Estimate TBW as 55 of lean body mass in men and 45 in women

            Serum sodium-140

            140

            The rate of fluid administration

            1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

            2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

            Hyponatremia Nalt135mEqL

            Causes

            1 Sodium depletion

            2 Sodium dilution

            bull Incidence = 45

            bull After surgery=1

            bull Mortality = 2 times normal

            Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

            volume deficit

            Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

            Sign and symptoms

            bull CNS symptom when Nalt123 meql

            bull Cardiac symptom when Nalt100 meql

            For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

            Body System Hyponatremia

            central nervous system Headache confusion hyper-or hypoactive deep tendon

            reflexes seizures coma increased intracranial pressure

            Musculoskeletal Weakness fatigue muscle crampstwitching

            Gastrointestinal Anorexia nausea vomiting watery diarrhea

            Cardiovascular Hypertension and bradycardia if significant increases in

            intracranial pressure

            Tissue Lacrimation salivation

            Renal Oliguria

            Clinical Manifestations of Abnormalities in Serum Sodium

            Treatment

            1=Depend on ECF

            2=CNS sign

            Treatment

            1 Asymptomatic increase the sodium level by no more than

            05-1 meqLh to a maximum increase of 12 meqL per day

            2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

            more than 1meqL per hour until the serum Na level reaches 130

            meqL or neurologic symptoms are improved

            Rapid correction of hyponatremia

            Pontine myelinolysis

            Seizures weaknessparesis akinetic

            movements unresponsiveness

            Permanent brain damage

            Death

            Dose

            Na deficit meq =(140- Na meql) TBW

            باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

            شود اصالح آهسته سپس

            Potassium abnormalities

            bull The average dietary intake of potassium 50-100meqd

            bull The average renal excretion of potassium 10-700 meqd

            - 2 of the total body potassium in ECF (45meqL)

            - Factors that influence serum potassium

            1 Surgical stress

            2 Injury

            3 Acidosis

            4 Tissue catabolism

            Hyperkalemia

            The normal range of serum potassium 35-5 meqL

            Etiology of Hyperkalemia

            Increased intake Potassium supplementation

            Blood transfusions

            Endogenous loaddestruction

            hemolysis rhabdomyolysis

            cruch injury gastrointestinal hemorrhage

            Increased release Acidosis

            Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

            Renal insufficiencyfailure

            Clinical manifestation of hyperkalemia

            System hyperkalemia

            Gastrointestinal Nauseavomiting colic diarrhea

            Neuromuscular weakness paralysis respiratory failure

            Cardiovascular Arrhythmia arrest

            ECG changes Peaked T waves (early change)

            Flattened P wave

            Prolonged PR interval (first-degree block)

            Widened QRS complex

            Sine wave formation

            Ventricular fibrillation

            Treatment

            Treatment of symptomatic hyperkalemia

            Potassium removal Kayexalate

            Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

            Rectal administration is 50 g in 200 mL 20 sorbitol

            Dialysis

            Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

            Bicarbonate 1 vial intravenous

            Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

            HypokalemiaEtiology

            inadequate intake

            Dietary potassium-free intravenous fluids potassium-deficient

            total parenteral nutrition

            Excessive potassium excretion

            Hyperaldosteronism

            Medications

            Gastrointestinal losses

            Direct loss of potassium from gastrointestinal fluid (diarrhea)

            Renal loss of potassium (gastric fluid either as vomiting or high

            nasogastric output)

            Intracellular-shift (metabolic alkalosis or insulin therapy)

            Potassium changes associated with alkalosis

            Potassium decrease by 03 meqL for every 01

            increase in PH above normal

            Magnesium Depletion

            (drug induced amphotericin amioglycosides cisplatin)

            Renal potassium wastage

            Hypokalemia

            Magnesium Depletion

            (drug induced amphotericin amioglycosides cisplatin)

            Renal potassium wastage

            Hypokalemia

            Clinical Manifestation of Abnormalities in potassium

            System hypokalemia

            Gastrointestinal Ileus constipation

            Neuromuscular Decreased reflexes fatigue weakness

            paralysis

            Cardiovascular Arrest

            ECG changes U-waves

            T-wave flattening

            ST-segment changes

            Arrhythmias

            Treatment

            Potassium

            Serum potassium level lt40 mEqL

            Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

            times 1 doses

            Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

            Symptomatic KC1 20 mEq IV q1h times 4 doses

            Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

            asymptomatic replace as per above protocol

            Electrolyte Replacement Therapy Protocol

            bull Oral repletion for mild and asymptomatic hypokalemia

            bull IV repletion for severe and symptomatic hypokalemia

            Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

            ( دندانها( ndash استخوانbull كلسيم نقش

            عصبي 1 ايمپالسهاي )NMJ(انتقال

            صاف 2 عضالت انقباض

            هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

            انعقاد 4

            یونیزه Calt45 meql هيپوكلسمي

            عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

            ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

            میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

            ( شود می پیوند شده

            هیپوکلسمی عالئم

            رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

            سایرعالئم

            قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

            درمان

            ای bull زمینه علت کردن طرف بروریدی bull کلسیم

            Cagt55meql هيپركلسمي

            هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

            عالئم

            bullGI

            bullCardiovascular bullRenal (polyuria)

            bullCNS

            قلبی عالئم

            bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

            QRS شدن )Q-Tوكوتاه

            درمان

            ایزوتونیک 1 نمکی محلول انفوزیون

            الزیکس2

            تونین 3 کلسی

            کورتون4

            دیالیز5

            Magnesium Abnormalities

            Normal dietary intake 20meq (240mg)

            Excretion in both the feces and urine

            Normal serum level 19-25 mgdL

            منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

            تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

            bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

            Hypermagnesemia

            Etiology

            1 Impaired renal function

            2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

            Clinical manifestation hypermanesemia

            System hypermanesemia

            Gastrointestinal Nauseavomiting

            Neuromuscular weakness lethargy Decreased

            reflexes

            Cardiovascular Hypotension arrest

            ECG changes Increased PR interval

            Widened QRS complex

            Elevated T waves

            Treatment

            1 Withhold exogenous sources of magnesium

            2 Correct volume deficit

            3 Correct acidosis if present

            4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

            5 Dialysis (if elevated levels or symptoms persist)

            عالئم

            bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

            meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

            meqL

            Hypomagnesemia

            Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

            homeostasis

            Etiology

            1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

            inadequate supplementation of magnesium)

            2 Increased renal excretion (alcohol most diuretics and amphotericin B)

            3 GI losses (diarrhea)

            4 Malabsorption

            5 Acute pancreatitis

            6 Diabetic ketoacidosis

            7 Primary aldosteronism

            Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

            1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

            2 Delirium and seizures in severe deficiency

            3 ECG changes Prolonged QT and PR interval

            ST-segment depression

            Flattening or inversion of P waves

            Torsades de pointes

            Arrhythmia

            Treatment

            1 For asymptomatic and mild hypomagnesemia administer oral mg

            2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

            Message for Today

            ICF

            Interstitial

            Pla

            sma

            5 Dex

            bull Do not reccussitate sick patients with any Dextrose solution

            • Fluid and Electrolyte Management of the Surgical Patient
            • Slide 2
            • Slide 3
            • Slide 4
            • Total Body Water
            • Body Fluid Compartments
            • Total body water (TBW)
            • Body compartment fluid
            • Example men with 70kg
            • Fluid compartments
            • Slide 11
            • Slide 12
            • Slide 13
            • Slide 14
            • Slide 15
            • Colloid osmotic pressure
            • Slide 17
            • Slide 18
            • Slide 19
            • Cell Membrane
            • Slide 21
            • Slide 22
            • Slide 23
            • Slide 24
            • Slide 25
            • Composition of Fluid Compartments
            • Composition of Body Fluids
            • عوامل موثر روی تغییرات آب والکترولیت
            • Reasons for fluid therapy
            • ارزیابی حجم مایع داخل عروقی
            • محلولهای وریدی
            • Fluids
            • Slide 33
            • Slide 34
            • Slide 35
            • Crystalloids
            • Colloid Solutions
            • رینگر لاکتات
            • 09Nacl
            • Postoperative (maintenance)
            • Slide 41
            • Preexisting fluid deficits
            • Maintenance requirements
            • Surgical fluid losses
            • Third space loss
            • Crystalloid solution
            • Colloids
            • Complications
            • The Influence of Colloid amp Crystalloid on Blood Volume
            • Colloid versus crystalloid solutions
            • Transfusion consideration
            • اختلال در حجم مایعات بدن
            • Fluid volume deficit (FVD)
            • DEHYDRATION
            • علل کاهش حجم خارج سلولی
            • Signs of Hypovolemia
            • Clinical Diagnosis of Hypovolemia
            • Signs of Hypervolemia
            • Management of Hypervolemia
            • Fluid Management
            • Electrolyte physiology
            • Sodium physiology
            • Osmotic Pressure
            • Concentration
            • Hypernatremia
            • - Hypernatremia
            • Slide 67
            • Slide 68
            • Clinical Manifestations of Abnormalities in Serum Sodium
            • Treatment
            • Water deficit (L)= times TBW
            • The rate of fluid administration
            • Hyponatremia Nalt135mEqL
            • Slide 74
            • Sodium depletion
            • Sodium dilution
            • Sign and symptoms
            • Slide 78
            • Treatment
            • Slide 80
            • Slide 81
            • Dose
            • Potassium abnormalities
            • Hyperkalemia
            • Clinical manifestation of hyperkalemia
            • Slide 86
            • Slide 87
            • Hypokalemia
            • Potassium changes associated with alkalosis
            • Slide 90
            • Clinical Manifestation of Abnormalities in potassium
            • Slide 92
            • Calcium
            • هيپوكلسمي یونیزه Calt45 meql
            • علائم هیپوکلسمی
            • Slide 96
            • Slide 97
            • Slide 98
            • Slide 99
            • سایرعلائم
            • درمان
            • هيپركلسمي Cagt55meql
            • علائم
            • علائم قلبی
            • Slide 105
            • Magnesium Abnormalities
            • منیزیوم
            • Hypermagnesemia
            • Clinical manifestation hypermanesemia
            • Slide 110
            • Slide 111
            • Hypomagnesemia
            • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
            • Slide 114
            • Message for Today
            • Slide 116

              Total body water (TBW)

              bull TBW varies with age gender and body habitus

              bull In adult males= 55 of body weight

              bull In adult female=45 of body weight

              bull In infant = 80 of body weight

              bull Obese patients have less TBW per Kg than lean body

              adult

              1= Intracellular fluid (ICF)=55 TBW or 30-40 BW

              2= Extracellular fluid (ECF) =45TBW or 20 BW

              Interstitial fluid =15 of body weight

              Intravascular fluid or plasma volume

              = 5 of body weight

              Body compartment fluid

              Example men with 70kg TBW= 5570 =385 L

              ICF = 55 385 =212L

              ECF = 45 385=173L

              1 ISF = 15 70 = 105L

              2 PV = 5 70 =35L

              Your User Name

              Fluid compartments

              ICF

              Fluid compartments

              ICF

              ECF

              Interstitial

              Pla

              sma

              Fluid compartments

              ICF

              ECF

              Interstitial

              Pla

              sma

              Fluid compartments

              ICF

              ECF

              Interstitial

              Pla

              sma

              Capillary Membrane

              Fluid compartments

              ICF

              ECF

              Interstitial

              Pla

              sma

              Capillary Membrane

              Fluid compartments

              ICF

              ECF

              Interstitial

              Pla

              sma

              Capillary Membrane Cell Membrane

              Colloid osmotic pressure

              ECF

              Interstitial

              Pla

              sma

              Capillary Membrane

              Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

              Colloid osmotic pressure

              ECF

              Interstitial

              Pla

              sma

              Capillary Membrane

              Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

              Colloid osmotic pressure

              ECF

              Interstitial

              Pla

              sma

              Capillary Membrane

              Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

              The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

              H2O

              H2O

              Colloid osmotic pressure

              ECF

              Interstitial

              Pla

              sma

              Capillary Membrane

              Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

              The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

              This is balanced out by the hydrostatic pressure difference

              H2O

              H2O12080

              H2O

              H2O

              Cell Membrane

              ICF

              Cell Membrane

              Interstitial

              H2O

              H2O

              Cell membrane is freely permeable to H20 but

              Cell Membrane

              ICF

              Cell Membrane

              Na+

              K+

              Interstitial

              H2O

              H2O

              Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

              Cell Membrane

              ICF

              Cell Membrane

              Na-

              K+

              Interstitial

              H2O

              H2O

              Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

              [K+] =4

              Cell Membrane

              ICF

              Cell Membrane

              Na-

              K+

              Interstitial

              H2O

              H2O

              Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

              [K+] =4 [K+] =150

              Cell Membrane

              ICF

              Cell Membrane

              Na-

              K+

              Interstitial

              H2O

              H2O

              Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

              [K+] =4 [K+] =150

              Na+= 144

              Cell Membrane

              ICF

              Cell Membrane

              Na-

              K+

              Interstitial

              H2O

              H2O

              Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

              [K+] =4 [K+] =150

              Na+= 144Na+= 10

              Composition of Fluid Compartments

              CATIONS ANIONS

              Na+ 142 Cl - 103

              HC03- 27

              504mdash

              3 PO4

              ---

              K+ 4 organicCa++ 5 Acid 5

              Mg++ 3 Protein 16

              CATIONS ANIONS

              Na+ 144 Cl - 114

              HC03- 30

              504mdash

              K+ 4 3 PO4

              ---

              organic

              Ca++ 3 Acid 5

              Mg++ 2 Protein 1

              CATIONS ANIONS

              K+ 150 HPO4

              150 504

              mdash

              HCO3- 10

              Mg++ 40 Protein 40

              Na+ 10

              154 mEqL 153 mEqL 153 mEqL154 mEqL

              PLASMA INTERSTITAL FLID

              200 mEqL 200 mEqL

              INTRACELLULAR FLID

              Composition of Body FluidsComposition of Body Fluids

              Ca 2+

              Mg 2+

              K+

              Na+

              Cl-

              PO43-

              Organic anion

              HCO3-

              Protein

              0

              50

              50

              100

              150

              100

              150

              Cations Anions

              EC

              FICF

              Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

              والکترولیت آب تغییرات روی موثر عوامل

              1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

              عمل 2 از قبل والکترولیت آب وضعیت

              اندوکرینوپاتی )3 همراه )بیماریهای

              4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

              Reasons for fluid therapyReasons for fluid therapy

              Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

              bull Correct hypovolaemiaCorrect hypovolaemia

              bull Maintain cardiac outputMaintain cardiac output

              bull Optimise gas exchangeOptimise gas exchange

              bull Replace electrolytes amp waterReplace electrolytes amp water

              bull Maintain urine outputMaintain urine output

              Colloids + RBCs

              Crystalloids

              Identify what is the goal

              Choose fluid which best achieves the goal

              عروقی داخل مایع حجم ارزیابی

              بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

              وریدی محلولهای

              Fluids bull Crystalloids

              bull Colloids

              bull blood

              Which of the following solutions is isotonic

              A D5W

              B 045 saline

              C 09 saline

              D D5 in 09 saline

              SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

              ECFECF 142 4 5 103 27 280-310

              Lactated Lactated RingerrsquosRingerrsquos

              130 4 3 109 28 273

              09 NaCl09 NaCl 154 154 308

              045 045 NaClNaCl

              77 77 154

              D5WD5W

              D5045 D5045 NaClNaCl

              77 77 50 406

              3 NaCl3 NaCl 513 513 1026

              6 6 HetastarchHetastarch

              500 154 154 310

              5 5 AlbuminAlbumin

              250500130-160

              lt25130-160

              330

              25 25 AlbuminAlbumin

              2050100130-160

              lt25130-160

              330

              Common parenteral fluid therapyCommon parenteral fluid therapy

              CrystalloidsCrystalloids

              bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

              Colloid SolutionsColloid Solutions

              bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

              - Haes-steril 10

              الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

              کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

              ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

              osm=273

              09Nacl

              bull Na=154

              bull CL= 154

              کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

              PH=56است

              Postoperative (maintenance)

              045Nacl +5 dextrose +KCL

              Perioperative management of fluid balance include

              1 Preoperative evaluation

              2 Intraoperative maintenance

              3 Replacement of fluid losses

              Preexisting fluid deficits

              bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

              bull Hypotonic fluid (05 saline ) or isotonic crystalloids

              Maintenance requirements

              bull Up to 10 kg = 4cckghr

              bull 11-20kg = add 2cckghr

              bull 21kg and above = add 1cckghr

              bull Insensible losses = 2cckghr

              Surgical fluid losses

              Blood loss (measurement)

              1 Suction container

              2 Surgical sponge

              3 Hct and tachycardia not specific

              4 ABG and UO if hypoperfusion occur

              5 Blood loss=31 with crystalloid

              Other losses (third space loss)

              Third space loss

              1 Minimal (herniorrapy) =2-4cckghr

              2 Moderate (cholecystectomy)=4-6cckghr

              3 Severe (bowel resection) = 6-8cckghr

              Crystalloid solution

              1 The main solutions is either glucose or saline

              2 Hypotonic or isotonic or hypertonic

              3 Safe nontoxic reaction free inexpensive

              4 Complication is edema if large volumes are needed

              5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

              Colloids

              1 Albumin

              2 Hydroxyethyl starch

              3 Dextran

              Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

              factor )These colloid is best avoided in patients with

              coagulopaty

              The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

              1000cc

              500cc

              500cc

              500cc

              200

              600

              1000

              Lactated Ringers

              5 Albumin

              6 Hetastarch

              Whole blood

              Blood volumeInfusion volume

              Colloid versus crystalloid solutions

              Transfusion consideration

              bull HB lt7 mg dl increase CO

              bull Ideal Hb is 7-8 mgdl

              bull In IHD patients or pulmonary disease gt 10 mgdl

              بدن مایعات حجم در اختالل

              1 Fluid volume deficit

              2 Fluid volume excess

              Fluid volume deficit(FVD)

              ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

              کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

              ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

              باشد آن با همراه دیگری اختالل مگر

              DEHYDRATION

              سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

              سلولی خارج حجم کاهش علل

              1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

              2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

              کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

              Signs of HypovolemiaSigns of Hypovolemia

              bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

              Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

              bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

              Signs of HypervolemiaSigns of Hypervolemia

              bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

              Especially when hypo-albuminemia

              Management of Management of HypervolemiaHypervolemia

              bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

              Fluid ManagementFluid Management

              bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

              Electrolyte physiology

              Sodium physiology

              Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

              Normal amount 135-145 meql

              Osmotic Pressure

              Calculated serum osmolality =

              2 sodium+ glucose18 + BUN 28

              Osmolality = 290 mosm

              Concentration

              1Serum sodium concentration2Serum osmolarity

              bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

              drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

              DW5)

              Hypernatremia

              Serum Nagt145mEqL

              - Hypernatremia

              Loss of Free Water

              Gain of sodium in excess of water

              Hypernatremia

              -Hypernatremia Hypo volemic

              Hyper volemic

              Normo volemic

              Hypernatremia

              Volume Status

              Normal

              Nonrenal water loss

              Skin

              Gastrointestinal

              Renal water loss

              Renal disease

              Diuretics

              Diabetes insipidus

              High

              Iatrogenic sodium administration

              Mineralocorticoid excess

              Aldosteronism

              Cushingrsquos disease

              Congenital adrenal

              hyperplasia

              Low

              Nonrenal water loss

              Skin

              Gastrointestinal losses

              Renal water losses

              Renal (tubular) Diuretics

              Osmotic diuretics

              Diabetes insipidus

              Adrenal failure

              Asymptomatic

              Hypernatremia Symptomatic (Nagt160 meqL)

              Clinical Manifestations of Abnormalities in Serum Sodium

              Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

              Body system hypernatremia

              Treatment

              Normal saline in hypovolemic patients

              Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

              saline or entral water)

              Water deficit (L)= times TBW

              The formula used to estimate the amount of water required to correct hypernatremia

              Estimate TBW as 55 of lean body mass in men and 45 in women

              Serum sodium-140

              140

              The rate of fluid administration

              1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

              2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

              Hyponatremia Nalt135mEqL

              Causes

              1 Sodium depletion

              2 Sodium dilution

              bull Incidence = 45

              bull After surgery=1

              bull Mortality = 2 times normal

              Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

              volume deficit

              Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

              Sign and symptoms

              bull CNS symptom when Nalt123 meql

              bull Cardiac symptom when Nalt100 meql

              For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

              Body System Hyponatremia

              central nervous system Headache confusion hyper-or hypoactive deep tendon

              reflexes seizures coma increased intracranial pressure

              Musculoskeletal Weakness fatigue muscle crampstwitching

              Gastrointestinal Anorexia nausea vomiting watery diarrhea

              Cardiovascular Hypertension and bradycardia if significant increases in

              intracranial pressure

              Tissue Lacrimation salivation

              Renal Oliguria

              Clinical Manifestations of Abnormalities in Serum Sodium

              Treatment

              1=Depend on ECF

              2=CNS sign

              Treatment

              1 Asymptomatic increase the sodium level by no more than

              05-1 meqLh to a maximum increase of 12 meqL per day

              2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

              more than 1meqL per hour until the serum Na level reaches 130

              meqL or neurologic symptoms are improved

              Rapid correction of hyponatremia

              Pontine myelinolysis

              Seizures weaknessparesis akinetic

              movements unresponsiveness

              Permanent brain damage

              Death

              Dose

              Na deficit meq =(140- Na meql) TBW

              باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

              شود اصالح آهسته سپس

              Potassium abnormalities

              bull The average dietary intake of potassium 50-100meqd

              bull The average renal excretion of potassium 10-700 meqd

              - 2 of the total body potassium in ECF (45meqL)

              - Factors that influence serum potassium

              1 Surgical stress

              2 Injury

              3 Acidosis

              4 Tissue catabolism

              Hyperkalemia

              The normal range of serum potassium 35-5 meqL

              Etiology of Hyperkalemia

              Increased intake Potassium supplementation

              Blood transfusions

              Endogenous loaddestruction

              hemolysis rhabdomyolysis

              cruch injury gastrointestinal hemorrhage

              Increased release Acidosis

              Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

              Renal insufficiencyfailure

              Clinical manifestation of hyperkalemia

              System hyperkalemia

              Gastrointestinal Nauseavomiting colic diarrhea

              Neuromuscular weakness paralysis respiratory failure

              Cardiovascular Arrhythmia arrest

              ECG changes Peaked T waves (early change)

              Flattened P wave

              Prolonged PR interval (first-degree block)

              Widened QRS complex

              Sine wave formation

              Ventricular fibrillation

              Treatment

              Treatment of symptomatic hyperkalemia

              Potassium removal Kayexalate

              Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

              Rectal administration is 50 g in 200 mL 20 sorbitol

              Dialysis

              Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

              Bicarbonate 1 vial intravenous

              Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

              HypokalemiaEtiology

              inadequate intake

              Dietary potassium-free intravenous fluids potassium-deficient

              total parenteral nutrition

              Excessive potassium excretion

              Hyperaldosteronism

              Medications

              Gastrointestinal losses

              Direct loss of potassium from gastrointestinal fluid (diarrhea)

              Renal loss of potassium (gastric fluid either as vomiting or high

              nasogastric output)

              Intracellular-shift (metabolic alkalosis or insulin therapy)

              Potassium changes associated with alkalosis

              Potassium decrease by 03 meqL for every 01

              increase in PH above normal

              Magnesium Depletion

              (drug induced amphotericin amioglycosides cisplatin)

              Renal potassium wastage

              Hypokalemia

              Magnesium Depletion

              (drug induced amphotericin amioglycosides cisplatin)

              Renal potassium wastage

              Hypokalemia

              Clinical Manifestation of Abnormalities in potassium

              System hypokalemia

              Gastrointestinal Ileus constipation

              Neuromuscular Decreased reflexes fatigue weakness

              paralysis

              Cardiovascular Arrest

              ECG changes U-waves

              T-wave flattening

              ST-segment changes

              Arrhythmias

              Treatment

              Potassium

              Serum potassium level lt40 mEqL

              Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

              times 1 doses

              Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

              Symptomatic KC1 20 mEq IV q1h times 4 doses

              Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

              asymptomatic replace as per above protocol

              Electrolyte Replacement Therapy Protocol

              bull Oral repletion for mild and asymptomatic hypokalemia

              bull IV repletion for severe and symptomatic hypokalemia

              Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

              ( دندانها( ndash استخوانbull كلسيم نقش

              عصبي 1 ايمپالسهاي )NMJ(انتقال

              صاف 2 عضالت انقباض

              هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

              انعقاد 4

              یونیزه Calt45 meql هيپوكلسمي

              عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

              ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

              میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

              ( شود می پیوند شده

              هیپوکلسمی عالئم

              رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

              سایرعالئم

              قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

              درمان

              ای bull زمینه علت کردن طرف بروریدی bull کلسیم

              Cagt55meql هيپركلسمي

              هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

              عالئم

              bullGI

              bullCardiovascular bullRenal (polyuria)

              bullCNS

              قلبی عالئم

              bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

              QRS شدن )Q-Tوكوتاه

              درمان

              ایزوتونیک 1 نمکی محلول انفوزیون

              الزیکس2

              تونین 3 کلسی

              کورتون4

              دیالیز5

              Magnesium Abnormalities

              Normal dietary intake 20meq (240mg)

              Excretion in both the feces and urine

              Normal serum level 19-25 mgdL

              منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

              تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

              bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

              Hypermagnesemia

              Etiology

              1 Impaired renal function

              2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

              Clinical manifestation hypermanesemia

              System hypermanesemia

              Gastrointestinal Nauseavomiting

              Neuromuscular weakness lethargy Decreased

              reflexes

              Cardiovascular Hypotension arrest

              ECG changes Increased PR interval

              Widened QRS complex

              Elevated T waves

              Treatment

              1 Withhold exogenous sources of magnesium

              2 Correct volume deficit

              3 Correct acidosis if present

              4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

              5 Dialysis (if elevated levels or symptoms persist)

              عالئم

              bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

              meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

              meqL

              Hypomagnesemia

              Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

              homeostasis

              Etiology

              1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

              inadequate supplementation of magnesium)

              2 Increased renal excretion (alcohol most diuretics and amphotericin B)

              3 GI losses (diarrhea)

              4 Malabsorption

              5 Acute pancreatitis

              6 Diabetic ketoacidosis

              7 Primary aldosteronism

              Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

              1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

              2 Delirium and seizures in severe deficiency

              3 ECG changes Prolonged QT and PR interval

              ST-segment depression

              Flattening or inversion of P waves

              Torsades de pointes

              Arrhythmia

              Treatment

              1 For asymptomatic and mild hypomagnesemia administer oral mg

              2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

              Message for Today

              ICF

              Interstitial

              Pla

              sma

              5 Dex

              bull Do not reccussitate sick patients with any Dextrose solution

              • Fluid and Electrolyte Management of the Surgical Patient
              • Slide 2
              • Slide 3
              • Slide 4
              • Total Body Water
              • Body Fluid Compartments
              • Total body water (TBW)
              • Body compartment fluid
              • Example men with 70kg
              • Fluid compartments
              • Slide 11
              • Slide 12
              • Slide 13
              • Slide 14
              • Slide 15
              • Colloid osmotic pressure
              • Slide 17
              • Slide 18
              • Slide 19
              • Cell Membrane
              • Slide 21
              • Slide 22
              • Slide 23
              • Slide 24
              • Slide 25
              • Composition of Fluid Compartments
              • Composition of Body Fluids
              • عوامل موثر روی تغییرات آب والکترولیت
              • Reasons for fluid therapy
              • ارزیابی حجم مایع داخل عروقی
              • محلولهای وریدی
              • Fluids
              • Slide 33
              • Slide 34
              • Slide 35
              • Crystalloids
              • Colloid Solutions
              • رینگر لاکتات
              • 09Nacl
              • Postoperative (maintenance)
              • Slide 41
              • Preexisting fluid deficits
              • Maintenance requirements
              • Surgical fluid losses
              • Third space loss
              • Crystalloid solution
              • Colloids
              • Complications
              • The Influence of Colloid amp Crystalloid on Blood Volume
              • Colloid versus crystalloid solutions
              • Transfusion consideration
              • اختلال در حجم مایعات بدن
              • Fluid volume deficit (FVD)
              • DEHYDRATION
              • علل کاهش حجم خارج سلولی
              • Signs of Hypovolemia
              • Clinical Diagnosis of Hypovolemia
              • Signs of Hypervolemia
              • Management of Hypervolemia
              • Fluid Management
              • Electrolyte physiology
              • Sodium physiology
              • Osmotic Pressure
              • Concentration
              • Hypernatremia
              • - Hypernatremia
              • Slide 67
              • Slide 68
              • Clinical Manifestations of Abnormalities in Serum Sodium
              • Treatment
              • Water deficit (L)= times TBW
              • The rate of fluid administration
              • Hyponatremia Nalt135mEqL
              • Slide 74
              • Sodium depletion
              • Sodium dilution
              • Sign and symptoms
              • Slide 78
              • Treatment
              • Slide 80
              • Slide 81
              • Dose
              • Potassium abnormalities
              • Hyperkalemia
              • Clinical manifestation of hyperkalemia
              • Slide 86
              • Slide 87
              • Hypokalemia
              • Potassium changes associated with alkalosis
              • Slide 90
              • Clinical Manifestation of Abnormalities in potassium
              • Slide 92
              • Calcium
              • هيپوكلسمي یونیزه Calt45 meql
              • علائم هیپوکلسمی
              • Slide 96
              • Slide 97
              • Slide 98
              • Slide 99
              • سایرعلائم
              • درمان
              • هيپركلسمي Cagt55meql
              • علائم
              • علائم قلبی
              • Slide 105
              • Magnesium Abnormalities
              • منیزیوم
              • Hypermagnesemia
              • Clinical manifestation hypermanesemia
              • Slide 110
              • Slide 111
              • Hypomagnesemia
              • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
              • Slide 114
              • Message for Today
              • Slide 116

                1= Intracellular fluid (ICF)=55 TBW or 30-40 BW

                2= Extracellular fluid (ECF) =45TBW or 20 BW

                Interstitial fluid =15 of body weight

                Intravascular fluid or plasma volume

                = 5 of body weight

                Body compartment fluid

                Example men with 70kg TBW= 5570 =385 L

                ICF = 55 385 =212L

                ECF = 45 385=173L

                1 ISF = 15 70 = 105L

                2 PV = 5 70 =35L

                Your User Name

                Fluid compartments

                ICF

                Fluid compartments

                ICF

                ECF

                Interstitial

                Pla

                sma

                Fluid compartments

                ICF

                ECF

                Interstitial

                Pla

                sma

                Fluid compartments

                ICF

                ECF

                Interstitial

                Pla

                sma

                Capillary Membrane

                Fluid compartments

                ICF

                ECF

                Interstitial

                Pla

                sma

                Capillary Membrane

                Fluid compartments

                ICF

                ECF

                Interstitial

                Pla

                sma

                Capillary Membrane Cell Membrane

                Colloid osmotic pressure

                ECF

                Interstitial

                Pla

                sma

                Capillary Membrane

                Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                Colloid osmotic pressure

                ECF

                Interstitial

                Pla

                sma

                Capillary Membrane

                Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                Colloid osmotic pressure

                ECF

                Interstitial

                Pla

                sma

                Capillary Membrane

                Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                H2O

                H2O

                Colloid osmotic pressure

                ECF

                Interstitial

                Pla

                sma

                Capillary Membrane

                Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                This is balanced out by the hydrostatic pressure difference

                H2O

                H2O12080

                H2O

                H2O

                Cell Membrane

                ICF

                Cell Membrane

                Interstitial

                H2O

                H2O

                Cell membrane is freely permeable to H20 but

                Cell Membrane

                ICF

                Cell Membrane

                Na+

                K+

                Interstitial

                H2O

                H2O

                Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                Cell Membrane

                ICF

                Cell Membrane

                Na-

                K+

                Interstitial

                H2O

                H2O

                Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                [K+] =4

                Cell Membrane

                ICF

                Cell Membrane

                Na-

                K+

                Interstitial

                H2O

                H2O

                Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                [K+] =4 [K+] =150

                Cell Membrane

                ICF

                Cell Membrane

                Na-

                K+

                Interstitial

                H2O

                H2O

                Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                [K+] =4 [K+] =150

                Na+= 144

                Cell Membrane

                ICF

                Cell Membrane

                Na-

                K+

                Interstitial

                H2O

                H2O

                Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                [K+] =4 [K+] =150

                Na+= 144Na+= 10

                Composition of Fluid Compartments

                CATIONS ANIONS

                Na+ 142 Cl - 103

                HC03- 27

                504mdash

                3 PO4

                ---

                K+ 4 organicCa++ 5 Acid 5

                Mg++ 3 Protein 16

                CATIONS ANIONS

                Na+ 144 Cl - 114

                HC03- 30

                504mdash

                K+ 4 3 PO4

                ---

                organic

                Ca++ 3 Acid 5

                Mg++ 2 Protein 1

                CATIONS ANIONS

                K+ 150 HPO4

                150 504

                mdash

                HCO3- 10

                Mg++ 40 Protein 40

                Na+ 10

                154 mEqL 153 mEqL 153 mEqL154 mEqL

                PLASMA INTERSTITAL FLID

                200 mEqL 200 mEqL

                INTRACELLULAR FLID

                Composition of Body FluidsComposition of Body Fluids

                Ca 2+

                Mg 2+

                K+

                Na+

                Cl-

                PO43-

                Organic anion

                HCO3-

                Protein

                0

                50

                50

                100

                150

                100

                150

                Cations Anions

                EC

                FICF

                Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                والکترولیت آب تغییرات روی موثر عوامل

                1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                عمل 2 از قبل والکترولیت آب وضعیت

                اندوکرینوپاتی )3 همراه )بیماریهای

                4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                Reasons for fluid therapyReasons for fluid therapy

                Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                bull Correct hypovolaemiaCorrect hypovolaemia

                bull Maintain cardiac outputMaintain cardiac output

                bull Optimise gas exchangeOptimise gas exchange

                bull Replace electrolytes amp waterReplace electrolytes amp water

                bull Maintain urine outputMaintain urine output

                Colloids + RBCs

                Crystalloids

                Identify what is the goal

                Choose fluid which best achieves the goal

                عروقی داخل مایع حجم ارزیابی

                بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                وریدی محلولهای

                Fluids bull Crystalloids

                bull Colloids

                bull blood

                Which of the following solutions is isotonic

                A D5W

                B 045 saline

                C 09 saline

                D D5 in 09 saline

                SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                ECFECF 142 4 5 103 27 280-310

                Lactated Lactated RingerrsquosRingerrsquos

                130 4 3 109 28 273

                09 NaCl09 NaCl 154 154 308

                045 045 NaClNaCl

                77 77 154

                D5WD5W

                D5045 D5045 NaClNaCl

                77 77 50 406

                3 NaCl3 NaCl 513 513 1026

                6 6 HetastarchHetastarch

                500 154 154 310

                5 5 AlbuminAlbumin

                250500130-160

                lt25130-160

                330

                25 25 AlbuminAlbumin

                2050100130-160

                lt25130-160

                330

                Common parenteral fluid therapyCommon parenteral fluid therapy

                CrystalloidsCrystalloids

                bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                Colloid SolutionsColloid Solutions

                bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                - Haes-steril 10

                الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                osm=273

                09Nacl

                bull Na=154

                bull CL= 154

                کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                PH=56است

                Postoperative (maintenance)

                045Nacl +5 dextrose +KCL

                Perioperative management of fluid balance include

                1 Preoperative evaluation

                2 Intraoperative maintenance

                3 Replacement of fluid losses

                Preexisting fluid deficits

                bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                Maintenance requirements

                bull Up to 10 kg = 4cckghr

                bull 11-20kg = add 2cckghr

                bull 21kg and above = add 1cckghr

                bull Insensible losses = 2cckghr

                Surgical fluid losses

                Blood loss (measurement)

                1 Suction container

                2 Surgical sponge

                3 Hct and tachycardia not specific

                4 ABG and UO if hypoperfusion occur

                5 Blood loss=31 with crystalloid

                Other losses (third space loss)

                Third space loss

                1 Minimal (herniorrapy) =2-4cckghr

                2 Moderate (cholecystectomy)=4-6cckghr

                3 Severe (bowel resection) = 6-8cckghr

                Crystalloid solution

                1 The main solutions is either glucose or saline

                2 Hypotonic or isotonic or hypertonic

                3 Safe nontoxic reaction free inexpensive

                4 Complication is edema if large volumes are needed

                5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                Colloids

                1 Albumin

                2 Hydroxyethyl starch

                3 Dextran

                Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                factor )These colloid is best avoided in patients with

                coagulopaty

                The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                1000cc

                500cc

                500cc

                500cc

                200

                600

                1000

                Lactated Ringers

                5 Albumin

                6 Hetastarch

                Whole blood

                Blood volumeInfusion volume

                Colloid versus crystalloid solutions

                Transfusion consideration

                bull HB lt7 mg dl increase CO

                bull Ideal Hb is 7-8 mgdl

                bull In IHD patients or pulmonary disease gt 10 mgdl

                بدن مایعات حجم در اختالل

                1 Fluid volume deficit

                2 Fluid volume excess

                Fluid volume deficit(FVD)

                ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                باشد آن با همراه دیگری اختالل مگر

                DEHYDRATION

                سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                سلولی خارج حجم کاهش علل

                1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                Signs of HypovolemiaSigns of Hypovolemia

                bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                Signs of HypervolemiaSigns of Hypervolemia

                bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                Especially when hypo-albuminemia

                Management of Management of HypervolemiaHypervolemia

                bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                Fluid ManagementFluid Management

                bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                Electrolyte physiology

                Sodium physiology

                Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                Normal amount 135-145 meql

                Osmotic Pressure

                Calculated serum osmolality =

                2 sodium+ glucose18 + BUN 28

                Osmolality = 290 mosm

                Concentration

                1Serum sodium concentration2Serum osmolarity

                bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                DW5)

                Hypernatremia

                Serum Nagt145mEqL

                - Hypernatremia

                Loss of Free Water

                Gain of sodium in excess of water

                Hypernatremia

                -Hypernatremia Hypo volemic

                Hyper volemic

                Normo volemic

                Hypernatremia

                Volume Status

                Normal

                Nonrenal water loss

                Skin

                Gastrointestinal

                Renal water loss

                Renal disease

                Diuretics

                Diabetes insipidus

                High

                Iatrogenic sodium administration

                Mineralocorticoid excess

                Aldosteronism

                Cushingrsquos disease

                Congenital adrenal

                hyperplasia

                Low

                Nonrenal water loss

                Skin

                Gastrointestinal losses

                Renal water losses

                Renal (tubular) Diuretics

                Osmotic diuretics

                Diabetes insipidus

                Adrenal failure

                Asymptomatic

                Hypernatremia Symptomatic (Nagt160 meqL)

                Clinical Manifestations of Abnormalities in Serum Sodium

                Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                Body system hypernatremia

                Treatment

                Normal saline in hypovolemic patients

                Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                saline or entral water)

                Water deficit (L)= times TBW

                The formula used to estimate the amount of water required to correct hypernatremia

                Estimate TBW as 55 of lean body mass in men and 45 in women

                Serum sodium-140

                140

                The rate of fluid administration

                1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                Hyponatremia Nalt135mEqL

                Causes

                1 Sodium depletion

                2 Sodium dilution

                bull Incidence = 45

                bull After surgery=1

                bull Mortality = 2 times normal

                Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                volume deficit

                Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                Sign and symptoms

                bull CNS symptom when Nalt123 meql

                bull Cardiac symptom when Nalt100 meql

                For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                Body System Hyponatremia

                central nervous system Headache confusion hyper-or hypoactive deep tendon

                reflexes seizures coma increased intracranial pressure

                Musculoskeletal Weakness fatigue muscle crampstwitching

                Gastrointestinal Anorexia nausea vomiting watery diarrhea

                Cardiovascular Hypertension and bradycardia if significant increases in

                intracranial pressure

                Tissue Lacrimation salivation

                Renal Oliguria

                Clinical Manifestations of Abnormalities in Serum Sodium

                Treatment

                1=Depend on ECF

                2=CNS sign

                Treatment

                1 Asymptomatic increase the sodium level by no more than

                05-1 meqLh to a maximum increase of 12 meqL per day

                2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                more than 1meqL per hour until the serum Na level reaches 130

                meqL or neurologic symptoms are improved

                Rapid correction of hyponatremia

                Pontine myelinolysis

                Seizures weaknessparesis akinetic

                movements unresponsiveness

                Permanent brain damage

                Death

                Dose

                Na deficit meq =(140- Na meql) TBW

                باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                شود اصالح آهسته سپس

                Potassium abnormalities

                bull The average dietary intake of potassium 50-100meqd

                bull The average renal excretion of potassium 10-700 meqd

                - 2 of the total body potassium in ECF (45meqL)

                - Factors that influence serum potassium

                1 Surgical stress

                2 Injury

                3 Acidosis

                4 Tissue catabolism

                Hyperkalemia

                The normal range of serum potassium 35-5 meqL

                Etiology of Hyperkalemia

                Increased intake Potassium supplementation

                Blood transfusions

                Endogenous loaddestruction

                hemolysis rhabdomyolysis

                cruch injury gastrointestinal hemorrhage

                Increased release Acidosis

                Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                Renal insufficiencyfailure

                Clinical manifestation of hyperkalemia

                System hyperkalemia

                Gastrointestinal Nauseavomiting colic diarrhea

                Neuromuscular weakness paralysis respiratory failure

                Cardiovascular Arrhythmia arrest

                ECG changes Peaked T waves (early change)

                Flattened P wave

                Prolonged PR interval (first-degree block)

                Widened QRS complex

                Sine wave formation

                Ventricular fibrillation

                Treatment

                Treatment of symptomatic hyperkalemia

                Potassium removal Kayexalate

                Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                Rectal administration is 50 g in 200 mL 20 sorbitol

                Dialysis

                Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                Bicarbonate 1 vial intravenous

                Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                HypokalemiaEtiology

                inadequate intake

                Dietary potassium-free intravenous fluids potassium-deficient

                total parenteral nutrition

                Excessive potassium excretion

                Hyperaldosteronism

                Medications

                Gastrointestinal losses

                Direct loss of potassium from gastrointestinal fluid (diarrhea)

                Renal loss of potassium (gastric fluid either as vomiting or high

                nasogastric output)

                Intracellular-shift (metabolic alkalosis or insulin therapy)

                Potassium changes associated with alkalosis

                Potassium decrease by 03 meqL for every 01

                increase in PH above normal

                Magnesium Depletion

                (drug induced amphotericin amioglycosides cisplatin)

                Renal potassium wastage

                Hypokalemia

                Magnesium Depletion

                (drug induced amphotericin amioglycosides cisplatin)

                Renal potassium wastage

                Hypokalemia

                Clinical Manifestation of Abnormalities in potassium

                System hypokalemia

                Gastrointestinal Ileus constipation

                Neuromuscular Decreased reflexes fatigue weakness

                paralysis

                Cardiovascular Arrest

                ECG changes U-waves

                T-wave flattening

                ST-segment changes

                Arrhythmias

                Treatment

                Potassium

                Serum potassium level lt40 mEqL

                Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                times 1 doses

                Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                Symptomatic KC1 20 mEq IV q1h times 4 doses

                Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                asymptomatic replace as per above protocol

                Electrolyte Replacement Therapy Protocol

                bull Oral repletion for mild and asymptomatic hypokalemia

                bull IV repletion for severe and symptomatic hypokalemia

                Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                ( دندانها( ndash استخوانbull كلسيم نقش

                عصبي 1 ايمپالسهاي )NMJ(انتقال

                صاف 2 عضالت انقباض

                هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                انعقاد 4

                یونیزه Calt45 meql هيپوكلسمي

                عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                ( شود می پیوند شده

                هیپوکلسمی عالئم

                رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                سایرعالئم

                قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                درمان

                ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                Cagt55meql هيپركلسمي

                هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                عالئم

                bullGI

                bullCardiovascular bullRenal (polyuria)

                bullCNS

                قلبی عالئم

                bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                QRS شدن )Q-Tوكوتاه

                درمان

                ایزوتونیک 1 نمکی محلول انفوزیون

                الزیکس2

                تونین 3 کلسی

                کورتون4

                دیالیز5

                Magnesium Abnormalities

                Normal dietary intake 20meq (240mg)

                Excretion in both the feces and urine

                Normal serum level 19-25 mgdL

                منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                Hypermagnesemia

                Etiology

                1 Impaired renal function

                2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                Clinical manifestation hypermanesemia

                System hypermanesemia

                Gastrointestinal Nauseavomiting

                Neuromuscular weakness lethargy Decreased

                reflexes

                Cardiovascular Hypotension arrest

                ECG changes Increased PR interval

                Widened QRS complex

                Elevated T waves

                Treatment

                1 Withhold exogenous sources of magnesium

                2 Correct volume deficit

                3 Correct acidosis if present

                4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                5 Dialysis (if elevated levels or symptoms persist)

                عالئم

                bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                meqL

                Hypomagnesemia

                Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                homeostasis

                Etiology

                1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                inadequate supplementation of magnesium)

                2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                3 GI losses (diarrhea)

                4 Malabsorption

                5 Acute pancreatitis

                6 Diabetic ketoacidosis

                7 Primary aldosteronism

                Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                2 Delirium and seizures in severe deficiency

                3 ECG changes Prolonged QT and PR interval

                ST-segment depression

                Flattening or inversion of P waves

                Torsades de pointes

                Arrhythmia

                Treatment

                1 For asymptomatic and mild hypomagnesemia administer oral mg

                2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                Message for Today

                ICF

                Interstitial

                Pla

                sma

                5 Dex

                bull Do not reccussitate sick patients with any Dextrose solution

                • Fluid and Electrolyte Management of the Surgical Patient
                • Slide 2
                • Slide 3
                • Slide 4
                • Total Body Water
                • Body Fluid Compartments
                • Total body water (TBW)
                • Body compartment fluid
                • Example men with 70kg
                • Fluid compartments
                • Slide 11
                • Slide 12
                • Slide 13
                • Slide 14
                • Slide 15
                • Colloid osmotic pressure
                • Slide 17
                • Slide 18
                • Slide 19
                • Cell Membrane
                • Slide 21
                • Slide 22
                • Slide 23
                • Slide 24
                • Slide 25
                • Composition of Fluid Compartments
                • Composition of Body Fluids
                • عوامل موثر روی تغییرات آب والکترولیت
                • Reasons for fluid therapy
                • ارزیابی حجم مایع داخل عروقی
                • محلولهای وریدی
                • Fluids
                • Slide 33
                • Slide 34
                • Slide 35
                • Crystalloids
                • Colloid Solutions
                • رینگر لاکتات
                • 09Nacl
                • Postoperative (maintenance)
                • Slide 41
                • Preexisting fluid deficits
                • Maintenance requirements
                • Surgical fluid losses
                • Third space loss
                • Crystalloid solution
                • Colloids
                • Complications
                • The Influence of Colloid amp Crystalloid on Blood Volume
                • Colloid versus crystalloid solutions
                • Transfusion consideration
                • اختلال در حجم مایعات بدن
                • Fluid volume deficit (FVD)
                • DEHYDRATION
                • علل کاهش حجم خارج سلولی
                • Signs of Hypovolemia
                • Clinical Diagnosis of Hypovolemia
                • Signs of Hypervolemia
                • Management of Hypervolemia
                • Fluid Management
                • Electrolyte physiology
                • Sodium physiology
                • Osmotic Pressure
                • Concentration
                • Hypernatremia
                • - Hypernatremia
                • Slide 67
                • Slide 68
                • Clinical Manifestations of Abnormalities in Serum Sodium
                • Treatment
                • Water deficit (L)= times TBW
                • The rate of fluid administration
                • Hyponatremia Nalt135mEqL
                • Slide 74
                • Sodium depletion
                • Sodium dilution
                • Sign and symptoms
                • Slide 78
                • Treatment
                • Slide 80
                • Slide 81
                • Dose
                • Potassium abnormalities
                • Hyperkalemia
                • Clinical manifestation of hyperkalemia
                • Slide 86
                • Slide 87
                • Hypokalemia
                • Potassium changes associated with alkalosis
                • Slide 90
                • Clinical Manifestation of Abnormalities in potassium
                • Slide 92
                • Calcium
                • هيپوكلسمي یونیزه Calt45 meql
                • علائم هیپوکلسمی
                • Slide 96
                • Slide 97
                • Slide 98
                • Slide 99
                • سایرعلائم
                • درمان
                • هيپركلسمي Cagt55meql
                • علائم
                • علائم قلبی
                • Slide 105
                • Magnesium Abnormalities
                • منیزیوم
                • Hypermagnesemia
                • Clinical manifestation hypermanesemia
                • Slide 110
                • Slide 111
                • Hypomagnesemia
                • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                • Slide 114
                • Message for Today
                • Slide 116

                  Example men with 70kg TBW= 5570 =385 L

                  ICF = 55 385 =212L

                  ECF = 45 385=173L

                  1 ISF = 15 70 = 105L

                  2 PV = 5 70 =35L

                  Your User Name

                  Fluid compartments

                  ICF

                  Fluid compartments

                  ICF

                  ECF

                  Interstitial

                  Pla

                  sma

                  Fluid compartments

                  ICF

                  ECF

                  Interstitial

                  Pla

                  sma

                  Fluid compartments

                  ICF

                  ECF

                  Interstitial

                  Pla

                  sma

                  Capillary Membrane

                  Fluid compartments

                  ICF

                  ECF

                  Interstitial

                  Pla

                  sma

                  Capillary Membrane

                  Fluid compartments

                  ICF

                  ECF

                  Interstitial

                  Pla

                  sma

                  Capillary Membrane Cell Membrane

                  Colloid osmotic pressure

                  ECF

                  Interstitial

                  Pla

                  sma

                  Capillary Membrane

                  Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                  Colloid osmotic pressure

                  ECF

                  Interstitial

                  Pla

                  sma

                  Capillary Membrane

                  Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                  Colloid osmotic pressure

                  ECF

                  Interstitial

                  Pla

                  sma

                  Capillary Membrane

                  Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                  The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                  H2O

                  H2O

                  Colloid osmotic pressure

                  ECF

                  Interstitial

                  Pla

                  sma

                  Capillary Membrane

                  Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                  The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                  This is balanced out by the hydrostatic pressure difference

                  H2O

                  H2O12080

                  H2O

                  H2O

                  Cell Membrane

                  ICF

                  Cell Membrane

                  Interstitial

                  H2O

                  H2O

                  Cell membrane is freely permeable to H20 but

                  Cell Membrane

                  ICF

                  Cell Membrane

                  Na+

                  K+

                  Interstitial

                  H2O

                  H2O

                  Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                  Cell Membrane

                  ICF

                  Cell Membrane

                  Na-

                  K+

                  Interstitial

                  H2O

                  H2O

                  Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                  [K+] =4

                  Cell Membrane

                  ICF

                  Cell Membrane

                  Na-

                  K+

                  Interstitial

                  H2O

                  H2O

                  Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                  [K+] =4 [K+] =150

                  Cell Membrane

                  ICF

                  Cell Membrane

                  Na-

                  K+

                  Interstitial

                  H2O

                  H2O

                  Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                  [K+] =4 [K+] =150

                  Na+= 144

                  Cell Membrane

                  ICF

                  Cell Membrane

                  Na-

                  K+

                  Interstitial

                  H2O

                  H2O

                  Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                  [K+] =4 [K+] =150

                  Na+= 144Na+= 10

                  Composition of Fluid Compartments

                  CATIONS ANIONS

                  Na+ 142 Cl - 103

                  HC03- 27

                  504mdash

                  3 PO4

                  ---

                  K+ 4 organicCa++ 5 Acid 5

                  Mg++ 3 Protein 16

                  CATIONS ANIONS

                  Na+ 144 Cl - 114

                  HC03- 30

                  504mdash

                  K+ 4 3 PO4

                  ---

                  organic

                  Ca++ 3 Acid 5

                  Mg++ 2 Protein 1

                  CATIONS ANIONS

                  K+ 150 HPO4

                  150 504

                  mdash

                  HCO3- 10

                  Mg++ 40 Protein 40

                  Na+ 10

                  154 mEqL 153 mEqL 153 mEqL154 mEqL

                  PLASMA INTERSTITAL FLID

                  200 mEqL 200 mEqL

                  INTRACELLULAR FLID

                  Composition of Body FluidsComposition of Body Fluids

                  Ca 2+

                  Mg 2+

                  K+

                  Na+

                  Cl-

                  PO43-

                  Organic anion

                  HCO3-

                  Protein

                  0

                  50

                  50

                  100

                  150

                  100

                  150

                  Cations Anions

                  EC

                  FICF

                  Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                  والکترولیت آب تغییرات روی موثر عوامل

                  1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                  عمل 2 از قبل والکترولیت آب وضعیت

                  اندوکرینوپاتی )3 همراه )بیماریهای

                  4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                  Reasons for fluid therapyReasons for fluid therapy

                  Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                  bull Correct hypovolaemiaCorrect hypovolaemia

                  bull Maintain cardiac outputMaintain cardiac output

                  bull Optimise gas exchangeOptimise gas exchange

                  bull Replace electrolytes amp waterReplace electrolytes amp water

                  bull Maintain urine outputMaintain urine output

                  Colloids + RBCs

                  Crystalloids

                  Identify what is the goal

                  Choose fluid which best achieves the goal

                  عروقی داخل مایع حجم ارزیابی

                  بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                  وریدی محلولهای

                  Fluids bull Crystalloids

                  bull Colloids

                  bull blood

                  Which of the following solutions is isotonic

                  A D5W

                  B 045 saline

                  C 09 saline

                  D D5 in 09 saline

                  SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                  ECFECF 142 4 5 103 27 280-310

                  Lactated Lactated RingerrsquosRingerrsquos

                  130 4 3 109 28 273

                  09 NaCl09 NaCl 154 154 308

                  045 045 NaClNaCl

                  77 77 154

                  D5WD5W

                  D5045 D5045 NaClNaCl

                  77 77 50 406

                  3 NaCl3 NaCl 513 513 1026

                  6 6 HetastarchHetastarch

                  500 154 154 310

                  5 5 AlbuminAlbumin

                  250500130-160

                  lt25130-160

                  330

                  25 25 AlbuminAlbumin

                  2050100130-160

                  lt25130-160

                  330

                  Common parenteral fluid therapyCommon parenteral fluid therapy

                  CrystalloidsCrystalloids

                  bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                  Colloid SolutionsColloid Solutions

                  bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                  - Haes-steril 10

                  الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                  کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                  ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                  osm=273

                  09Nacl

                  bull Na=154

                  bull CL= 154

                  کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                  PH=56است

                  Postoperative (maintenance)

                  045Nacl +5 dextrose +KCL

                  Perioperative management of fluid balance include

                  1 Preoperative evaluation

                  2 Intraoperative maintenance

                  3 Replacement of fluid losses

                  Preexisting fluid deficits

                  bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                  bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                  Maintenance requirements

                  bull Up to 10 kg = 4cckghr

                  bull 11-20kg = add 2cckghr

                  bull 21kg and above = add 1cckghr

                  bull Insensible losses = 2cckghr

                  Surgical fluid losses

                  Blood loss (measurement)

                  1 Suction container

                  2 Surgical sponge

                  3 Hct and tachycardia not specific

                  4 ABG and UO if hypoperfusion occur

                  5 Blood loss=31 with crystalloid

                  Other losses (third space loss)

                  Third space loss

                  1 Minimal (herniorrapy) =2-4cckghr

                  2 Moderate (cholecystectomy)=4-6cckghr

                  3 Severe (bowel resection) = 6-8cckghr

                  Crystalloid solution

                  1 The main solutions is either glucose or saline

                  2 Hypotonic or isotonic or hypertonic

                  3 Safe nontoxic reaction free inexpensive

                  4 Complication is edema if large volumes are needed

                  5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                  Colloids

                  1 Albumin

                  2 Hydroxyethyl starch

                  3 Dextran

                  Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                  factor )These colloid is best avoided in patients with

                  coagulopaty

                  The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                  1000cc

                  500cc

                  500cc

                  500cc

                  200

                  600

                  1000

                  Lactated Ringers

                  5 Albumin

                  6 Hetastarch

                  Whole blood

                  Blood volumeInfusion volume

                  Colloid versus crystalloid solutions

                  Transfusion consideration

                  bull HB lt7 mg dl increase CO

                  bull Ideal Hb is 7-8 mgdl

                  bull In IHD patients or pulmonary disease gt 10 mgdl

                  بدن مایعات حجم در اختالل

                  1 Fluid volume deficit

                  2 Fluid volume excess

                  Fluid volume deficit(FVD)

                  ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                  کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                  ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                  باشد آن با همراه دیگری اختالل مگر

                  DEHYDRATION

                  سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                  سلولی خارج حجم کاهش علل

                  1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                  2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                  کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                  Signs of HypovolemiaSigns of Hypovolemia

                  bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                  Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                  bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                  Signs of HypervolemiaSigns of Hypervolemia

                  bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                  Especially when hypo-albuminemia

                  Management of Management of HypervolemiaHypervolemia

                  bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                  Fluid ManagementFluid Management

                  bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                  Electrolyte physiology

                  Sodium physiology

                  Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                  Normal amount 135-145 meql

                  Osmotic Pressure

                  Calculated serum osmolality =

                  2 sodium+ glucose18 + BUN 28

                  Osmolality = 290 mosm

                  Concentration

                  1Serum sodium concentration2Serum osmolarity

                  bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                  drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                  DW5)

                  Hypernatremia

                  Serum Nagt145mEqL

                  - Hypernatremia

                  Loss of Free Water

                  Gain of sodium in excess of water

                  Hypernatremia

                  -Hypernatremia Hypo volemic

                  Hyper volemic

                  Normo volemic

                  Hypernatremia

                  Volume Status

                  Normal

                  Nonrenal water loss

                  Skin

                  Gastrointestinal

                  Renal water loss

                  Renal disease

                  Diuretics

                  Diabetes insipidus

                  High

                  Iatrogenic sodium administration

                  Mineralocorticoid excess

                  Aldosteronism

                  Cushingrsquos disease

                  Congenital adrenal

                  hyperplasia

                  Low

                  Nonrenal water loss

                  Skin

                  Gastrointestinal losses

                  Renal water losses

                  Renal (tubular) Diuretics

                  Osmotic diuretics

                  Diabetes insipidus

                  Adrenal failure

                  Asymptomatic

                  Hypernatremia Symptomatic (Nagt160 meqL)

                  Clinical Manifestations of Abnormalities in Serum Sodium

                  Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                  Body system hypernatremia

                  Treatment

                  Normal saline in hypovolemic patients

                  Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                  saline or entral water)

                  Water deficit (L)= times TBW

                  The formula used to estimate the amount of water required to correct hypernatremia

                  Estimate TBW as 55 of lean body mass in men and 45 in women

                  Serum sodium-140

                  140

                  The rate of fluid administration

                  1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                  2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                  Hyponatremia Nalt135mEqL

                  Causes

                  1 Sodium depletion

                  2 Sodium dilution

                  bull Incidence = 45

                  bull After surgery=1

                  bull Mortality = 2 times normal

                  Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                  volume deficit

                  Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                  Sign and symptoms

                  bull CNS symptom when Nalt123 meql

                  bull Cardiac symptom when Nalt100 meql

                  For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                  Body System Hyponatremia

                  central nervous system Headache confusion hyper-or hypoactive deep tendon

                  reflexes seizures coma increased intracranial pressure

                  Musculoskeletal Weakness fatigue muscle crampstwitching

                  Gastrointestinal Anorexia nausea vomiting watery diarrhea

                  Cardiovascular Hypertension and bradycardia if significant increases in

                  intracranial pressure

                  Tissue Lacrimation salivation

                  Renal Oliguria

                  Clinical Manifestations of Abnormalities in Serum Sodium

                  Treatment

                  1=Depend on ECF

                  2=CNS sign

                  Treatment

                  1 Asymptomatic increase the sodium level by no more than

                  05-1 meqLh to a maximum increase of 12 meqL per day

                  2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                  more than 1meqL per hour until the serum Na level reaches 130

                  meqL or neurologic symptoms are improved

                  Rapid correction of hyponatremia

                  Pontine myelinolysis

                  Seizures weaknessparesis akinetic

                  movements unresponsiveness

                  Permanent brain damage

                  Death

                  Dose

                  Na deficit meq =(140- Na meql) TBW

                  باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                  شود اصالح آهسته سپس

                  Potassium abnormalities

                  bull The average dietary intake of potassium 50-100meqd

                  bull The average renal excretion of potassium 10-700 meqd

                  - 2 of the total body potassium in ECF (45meqL)

                  - Factors that influence serum potassium

                  1 Surgical stress

                  2 Injury

                  3 Acidosis

                  4 Tissue catabolism

                  Hyperkalemia

                  The normal range of serum potassium 35-5 meqL

                  Etiology of Hyperkalemia

                  Increased intake Potassium supplementation

                  Blood transfusions

                  Endogenous loaddestruction

                  hemolysis rhabdomyolysis

                  cruch injury gastrointestinal hemorrhage

                  Increased release Acidosis

                  Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                  Renal insufficiencyfailure

                  Clinical manifestation of hyperkalemia

                  System hyperkalemia

                  Gastrointestinal Nauseavomiting colic diarrhea

                  Neuromuscular weakness paralysis respiratory failure

                  Cardiovascular Arrhythmia arrest

                  ECG changes Peaked T waves (early change)

                  Flattened P wave

                  Prolonged PR interval (first-degree block)

                  Widened QRS complex

                  Sine wave formation

                  Ventricular fibrillation

                  Treatment

                  Treatment of symptomatic hyperkalemia

                  Potassium removal Kayexalate

                  Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                  Rectal administration is 50 g in 200 mL 20 sorbitol

                  Dialysis

                  Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                  Bicarbonate 1 vial intravenous

                  Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                  HypokalemiaEtiology

                  inadequate intake

                  Dietary potassium-free intravenous fluids potassium-deficient

                  total parenteral nutrition

                  Excessive potassium excretion

                  Hyperaldosteronism

                  Medications

                  Gastrointestinal losses

                  Direct loss of potassium from gastrointestinal fluid (diarrhea)

                  Renal loss of potassium (gastric fluid either as vomiting or high

                  nasogastric output)

                  Intracellular-shift (metabolic alkalosis or insulin therapy)

                  Potassium changes associated with alkalosis

                  Potassium decrease by 03 meqL for every 01

                  increase in PH above normal

                  Magnesium Depletion

                  (drug induced amphotericin amioglycosides cisplatin)

                  Renal potassium wastage

                  Hypokalemia

                  Magnesium Depletion

                  (drug induced amphotericin amioglycosides cisplatin)

                  Renal potassium wastage

                  Hypokalemia

                  Clinical Manifestation of Abnormalities in potassium

                  System hypokalemia

                  Gastrointestinal Ileus constipation

                  Neuromuscular Decreased reflexes fatigue weakness

                  paralysis

                  Cardiovascular Arrest

                  ECG changes U-waves

                  T-wave flattening

                  ST-segment changes

                  Arrhythmias

                  Treatment

                  Potassium

                  Serum potassium level lt40 mEqL

                  Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                  times 1 doses

                  Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                  Symptomatic KC1 20 mEq IV q1h times 4 doses

                  Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                  asymptomatic replace as per above protocol

                  Electrolyte Replacement Therapy Protocol

                  bull Oral repletion for mild and asymptomatic hypokalemia

                  bull IV repletion for severe and symptomatic hypokalemia

                  Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                  ( دندانها( ndash استخوانbull كلسيم نقش

                  عصبي 1 ايمپالسهاي )NMJ(انتقال

                  صاف 2 عضالت انقباض

                  هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                  انعقاد 4

                  یونیزه Calt45 meql هيپوكلسمي

                  عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                  ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                  میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                  ( شود می پیوند شده

                  هیپوکلسمی عالئم

                  رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                  سایرعالئم

                  قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                  درمان

                  ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                  Cagt55meql هيپركلسمي

                  هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                  عالئم

                  bullGI

                  bullCardiovascular bullRenal (polyuria)

                  bullCNS

                  قلبی عالئم

                  bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                  QRS شدن )Q-Tوكوتاه

                  درمان

                  ایزوتونیک 1 نمکی محلول انفوزیون

                  الزیکس2

                  تونین 3 کلسی

                  کورتون4

                  دیالیز5

                  Magnesium Abnormalities

                  Normal dietary intake 20meq (240mg)

                  Excretion in both the feces and urine

                  Normal serum level 19-25 mgdL

                  منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                  تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                  bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                  Hypermagnesemia

                  Etiology

                  1 Impaired renal function

                  2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                  Clinical manifestation hypermanesemia

                  System hypermanesemia

                  Gastrointestinal Nauseavomiting

                  Neuromuscular weakness lethargy Decreased

                  reflexes

                  Cardiovascular Hypotension arrest

                  ECG changes Increased PR interval

                  Widened QRS complex

                  Elevated T waves

                  Treatment

                  1 Withhold exogenous sources of magnesium

                  2 Correct volume deficit

                  3 Correct acidosis if present

                  4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                  5 Dialysis (if elevated levels or symptoms persist)

                  عالئم

                  bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                  meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                  meqL

                  Hypomagnesemia

                  Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                  homeostasis

                  Etiology

                  1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                  inadequate supplementation of magnesium)

                  2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                  3 GI losses (diarrhea)

                  4 Malabsorption

                  5 Acute pancreatitis

                  6 Diabetic ketoacidosis

                  7 Primary aldosteronism

                  Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                  1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                  2 Delirium and seizures in severe deficiency

                  3 ECG changes Prolonged QT and PR interval

                  ST-segment depression

                  Flattening or inversion of P waves

                  Torsades de pointes

                  Arrhythmia

                  Treatment

                  1 For asymptomatic and mild hypomagnesemia administer oral mg

                  2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                  Message for Today

                  ICF

                  Interstitial

                  Pla

                  sma

                  5 Dex

                  bull Do not reccussitate sick patients with any Dextrose solution

                  • Fluid and Electrolyte Management of the Surgical Patient
                  • Slide 2
                  • Slide 3
                  • Slide 4
                  • Total Body Water
                  • Body Fluid Compartments
                  • Total body water (TBW)
                  • Body compartment fluid
                  • Example men with 70kg
                  • Fluid compartments
                  • Slide 11
                  • Slide 12
                  • Slide 13
                  • Slide 14
                  • Slide 15
                  • Colloid osmotic pressure
                  • Slide 17
                  • Slide 18
                  • Slide 19
                  • Cell Membrane
                  • Slide 21
                  • Slide 22
                  • Slide 23
                  • Slide 24
                  • Slide 25
                  • Composition of Fluid Compartments
                  • Composition of Body Fluids
                  • عوامل موثر روی تغییرات آب والکترولیت
                  • Reasons for fluid therapy
                  • ارزیابی حجم مایع داخل عروقی
                  • محلولهای وریدی
                  • Fluids
                  • Slide 33
                  • Slide 34
                  • Slide 35
                  • Crystalloids
                  • Colloid Solutions
                  • رینگر لاکتات
                  • 09Nacl
                  • Postoperative (maintenance)
                  • Slide 41
                  • Preexisting fluid deficits
                  • Maintenance requirements
                  • Surgical fluid losses
                  • Third space loss
                  • Crystalloid solution
                  • Colloids
                  • Complications
                  • The Influence of Colloid amp Crystalloid on Blood Volume
                  • Colloid versus crystalloid solutions
                  • Transfusion consideration
                  • اختلال در حجم مایعات بدن
                  • Fluid volume deficit (FVD)
                  • DEHYDRATION
                  • علل کاهش حجم خارج سلولی
                  • Signs of Hypovolemia
                  • Clinical Diagnosis of Hypovolemia
                  • Signs of Hypervolemia
                  • Management of Hypervolemia
                  • Fluid Management
                  • Electrolyte physiology
                  • Sodium physiology
                  • Osmotic Pressure
                  • Concentration
                  • Hypernatremia
                  • - Hypernatremia
                  • Slide 67
                  • Slide 68
                  • Clinical Manifestations of Abnormalities in Serum Sodium
                  • Treatment
                  • Water deficit (L)= times TBW
                  • The rate of fluid administration
                  • Hyponatremia Nalt135mEqL
                  • Slide 74
                  • Sodium depletion
                  • Sodium dilution
                  • Sign and symptoms
                  • Slide 78
                  • Treatment
                  • Slide 80
                  • Slide 81
                  • Dose
                  • Potassium abnormalities
                  • Hyperkalemia
                  • Clinical manifestation of hyperkalemia
                  • Slide 86
                  • Slide 87
                  • Hypokalemia
                  • Potassium changes associated with alkalosis
                  • Slide 90
                  • Clinical Manifestation of Abnormalities in potassium
                  • Slide 92
                  • Calcium
                  • هيپوكلسمي یونیزه Calt45 meql
                  • علائم هیپوکلسمی
                  • Slide 96
                  • Slide 97
                  • Slide 98
                  • Slide 99
                  • سایرعلائم
                  • درمان
                  • هيپركلسمي Cagt55meql
                  • علائم
                  • علائم قلبی
                  • Slide 105
                  • Magnesium Abnormalities
                  • منیزیوم
                  • Hypermagnesemia
                  • Clinical manifestation hypermanesemia
                  • Slide 110
                  • Slide 111
                  • Hypomagnesemia
                  • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                  • Slide 114
                  • Message for Today
                  • Slide 116

                    Fluid compartments

                    ICF

                    Fluid compartments

                    ICF

                    ECF

                    Interstitial

                    Pla

                    sma

                    Fluid compartments

                    ICF

                    ECF

                    Interstitial

                    Pla

                    sma

                    Fluid compartments

                    ICF

                    ECF

                    Interstitial

                    Pla

                    sma

                    Capillary Membrane

                    Fluid compartments

                    ICF

                    ECF

                    Interstitial

                    Pla

                    sma

                    Capillary Membrane

                    Fluid compartments

                    ICF

                    ECF

                    Interstitial

                    Pla

                    sma

                    Capillary Membrane Cell Membrane

                    Colloid osmotic pressure

                    ECF

                    Interstitial

                    Pla

                    sma

                    Capillary Membrane

                    Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                    Colloid osmotic pressure

                    ECF

                    Interstitial

                    Pla

                    sma

                    Capillary Membrane

                    Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                    Colloid osmotic pressure

                    ECF

                    Interstitial

                    Pla

                    sma

                    Capillary Membrane

                    Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                    The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                    H2O

                    H2O

                    Colloid osmotic pressure

                    ECF

                    Interstitial

                    Pla

                    sma

                    Capillary Membrane

                    Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                    The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                    This is balanced out by the hydrostatic pressure difference

                    H2O

                    H2O12080

                    H2O

                    H2O

                    Cell Membrane

                    ICF

                    Cell Membrane

                    Interstitial

                    H2O

                    H2O

                    Cell membrane is freely permeable to H20 but

                    Cell Membrane

                    ICF

                    Cell Membrane

                    Na+

                    K+

                    Interstitial

                    H2O

                    H2O

                    Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                    Cell Membrane

                    ICF

                    Cell Membrane

                    Na-

                    K+

                    Interstitial

                    H2O

                    H2O

                    Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                    [K+] =4

                    Cell Membrane

                    ICF

                    Cell Membrane

                    Na-

                    K+

                    Interstitial

                    H2O

                    H2O

                    Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                    [K+] =4 [K+] =150

                    Cell Membrane

                    ICF

                    Cell Membrane

                    Na-

                    K+

                    Interstitial

                    H2O

                    H2O

                    Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                    [K+] =4 [K+] =150

                    Na+= 144

                    Cell Membrane

                    ICF

                    Cell Membrane

                    Na-

                    K+

                    Interstitial

                    H2O

                    H2O

                    Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                    [K+] =4 [K+] =150

                    Na+= 144Na+= 10

                    Composition of Fluid Compartments

                    CATIONS ANIONS

                    Na+ 142 Cl - 103

                    HC03- 27

                    504mdash

                    3 PO4

                    ---

                    K+ 4 organicCa++ 5 Acid 5

                    Mg++ 3 Protein 16

                    CATIONS ANIONS

                    Na+ 144 Cl - 114

                    HC03- 30

                    504mdash

                    K+ 4 3 PO4

                    ---

                    organic

                    Ca++ 3 Acid 5

                    Mg++ 2 Protein 1

                    CATIONS ANIONS

                    K+ 150 HPO4

                    150 504

                    mdash

                    HCO3- 10

                    Mg++ 40 Protein 40

                    Na+ 10

                    154 mEqL 153 mEqL 153 mEqL154 mEqL

                    PLASMA INTERSTITAL FLID

                    200 mEqL 200 mEqL

                    INTRACELLULAR FLID

                    Composition of Body FluidsComposition of Body Fluids

                    Ca 2+

                    Mg 2+

                    K+

                    Na+

                    Cl-

                    PO43-

                    Organic anion

                    HCO3-

                    Protein

                    0

                    50

                    50

                    100

                    150

                    100

                    150

                    Cations Anions

                    EC

                    FICF

                    Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                    والکترولیت آب تغییرات روی موثر عوامل

                    1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                    عمل 2 از قبل والکترولیت آب وضعیت

                    اندوکرینوپاتی )3 همراه )بیماریهای

                    4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                    Reasons for fluid therapyReasons for fluid therapy

                    Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                    bull Correct hypovolaemiaCorrect hypovolaemia

                    bull Maintain cardiac outputMaintain cardiac output

                    bull Optimise gas exchangeOptimise gas exchange

                    bull Replace electrolytes amp waterReplace electrolytes amp water

                    bull Maintain urine outputMaintain urine output

                    Colloids + RBCs

                    Crystalloids

                    Identify what is the goal

                    Choose fluid which best achieves the goal

                    عروقی داخل مایع حجم ارزیابی

                    بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                    وریدی محلولهای

                    Fluids bull Crystalloids

                    bull Colloids

                    bull blood

                    Which of the following solutions is isotonic

                    A D5W

                    B 045 saline

                    C 09 saline

                    D D5 in 09 saline

                    SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                    ECFECF 142 4 5 103 27 280-310

                    Lactated Lactated RingerrsquosRingerrsquos

                    130 4 3 109 28 273

                    09 NaCl09 NaCl 154 154 308

                    045 045 NaClNaCl

                    77 77 154

                    D5WD5W

                    D5045 D5045 NaClNaCl

                    77 77 50 406

                    3 NaCl3 NaCl 513 513 1026

                    6 6 HetastarchHetastarch

                    500 154 154 310

                    5 5 AlbuminAlbumin

                    250500130-160

                    lt25130-160

                    330

                    25 25 AlbuminAlbumin

                    2050100130-160

                    lt25130-160

                    330

                    Common parenteral fluid therapyCommon parenteral fluid therapy

                    CrystalloidsCrystalloids

                    bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                    Colloid SolutionsColloid Solutions

                    bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                    - Haes-steril 10

                    الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                    کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                    ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                    osm=273

                    09Nacl

                    bull Na=154

                    bull CL= 154

                    کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                    PH=56است

                    Postoperative (maintenance)

                    045Nacl +5 dextrose +KCL

                    Perioperative management of fluid balance include

                    1 Preoperative evaluation

                    2 Intraoperative maintenance

                    3 Replacement of fluid losses

                    Preexisting fluid deficits

                    bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                    bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                    Maintenance requirements

                    bull Up to 10 kg = 4cckghr

                    bull 11-20kg = add 2cckghr

                    bull 21kg and above = add 1cckghr

                    bull Insensible losses = 2cckghr

                    Surgical fluid losses

                    Blood loss (measurement)

                    1 Suction container

                    2 Surgical sponge

                    3 Hct and tachycardia not specific

                    4 ABG and UO if hypoperfusion occur

                    5 Blood loss=31 with crystalloid

                    Other losses (third space loss)

                    Third space loss

                    1 Minimal (herniorrapy) =2-4cckghr

                    2 Moderate (cholecystectomy)=4-6cckghr

                    3 Severe (bowel resection) = 6-8cckghr

                    Crystalloid solution

                    1 The main solutions is either glucose or saline

                    2 Hypotonic or isotonic or hypertonic

                    3 Safe nontoxic reaction free inexpensive

                    4 Complication is edema if large volumes are needed

                    5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                    Colloids

                    1 Albumin

                    2 Hydroxyethyl starch

                    3 Dextran

                    Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                    factor )These colloid is best avoided in patients with

                    coagulopaty

                    The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                    1000cc

                    500cc

                    500cc

                    500cc

                    200

                    600

                    1000

                    Lactated Ringers

                    5 Albumin

                    6 Hetastarch

                    Whole blood

                    Blood volumeInfusion volume

                    Colloid versus crystalloid solutions

                    Transfusion consideration

                    bull HB lt7 mg dl increase CO

                    bull Ideal Hb is 7-8 mgdl

                    bull In IHD patients or pulmonary disease gt 10 mgdl

                    بدن مایعات حجم در اختالل

                    1 Fluid volume deficit

                    2 Fluid volume excess

                    Fluid volume deficit(FVD)

                    ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                    کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                    ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                    باشد آن با همراه دیگری اختالل مگر

                    DEHYDRATION

                    سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                    سلولی خارج حجم کاهش علل

                    1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                    2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                    کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                    Signs of HypovolemiaSigns of Hypovolemia

                    bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                    Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                    bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                    Signs of HypervolemiaSigns of Hypervolemia

                    bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                    Especially when hypo-albuminemia

                    Management of Management of HypervolemiaHypervolemia

                    bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                    Fluid ManagementFluid Management

                    bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                    Electrolyte physiology

                    Sodium physiology

                    Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                    Normal amount 135-145 meql

                    Osmotic Pressure

                    Calculated serum osmolality =

                    2 sodium+ glucose18 + BUN 28

                    Osmolality = 290 mosm

                    Concentration

                    1Serum sodium concentration2Serum osmolarity

                    bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                    drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                    DW5)

                    Hypernatremia

                    Serum Nagt145mEqL

                    - Hypernatremia

                    Loss of Free Water

                    Gain of sodium in excess of water

                    Hypernatremia

                    -Hypernatremia Hypo volemic

                    Hyper volemic

                    Normo volemic

                    Hypernatremia

                    Volume Status

                    Normal

                    Nonrenal water loss

                    Skin

                    Gastrointestinal

                    Renal water loss

                    Renal disease

                    Diuretics

                    Diabetes insipidus

                    High

                    Iatrogenic sodium administration

                    Mineralocorticoid excess

                    Aldosteronism

                    Cushingrsquos disease

                    Congenital adrenal

                    hyperplasia

                    Low

                    Nonrenal water loss

                    Skin

                    Gastrointestinal losses

                    Renal water losses

                    Renal (tubular) Diuretics

                    Osmotic diuretics

                    Diabetes insipidus

                    Adrenal failure

                    Asymptomatic

                    Hypernatremia Symptomatic (Nagt160 meqL)

                    Clinical Manifestations of Abnormalities in Serum Sodium

                    Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                    Body system hypernatremia

                    Treatment

                    Normal saline in hypovolemic patients

                    Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                    saline or entral water)

                    Water deficit (L)= times TBW

                    The formula used to estimate the amount of water required to correct hypernatremia

                    Estimate TBW as 55 of lean body mass in men and 45 in women

                    Serum sodium-140

                    140

                    The rate of fluid administration

                    1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                    2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                    Hyponatremia Nalt135mEqL

                    Causes

                    1 Sodium depletion

                    2 Sodium dilution

                    bull Incidence = 45

                    bull After surgery=1

                    bull Mortality = 2 times normal

                    Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                    volume deficit

                    Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                    Sign and symptoms

                    bull CNS symptom when Nalt123 meql

                    bull Cardiac symptom when Nalt100 meql

                    For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                    Body System Hyponatremia

                    central nervous system Headache confusion hyper-or hypoactive deep tendon

                    reflexes seizures coma increased intracranial pressure

                    Musculoskeletal Weakness fatigue muscle crampstwitching

                    Gastrointestinal Anorexia nausea vomiting watery diarrhea

                    Cardiovascular Hypertension and bradycardia if significant increases in

                    intracranial pressure

                    Tissue Lacrimation salivation

                    Renal Oliguria

                    Clinical Manifestations of Abnormalities in Serum Sodium

                    Treatment

                    1=Depend on ECF

                    2=CNS sign

                    Treatment

                    1 Asymptomatic increase the sodium level by no more than

                    05-1 meqLh to a maximum increase of 12 meqL per day

                    2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                    more than 1meqL per hour until the serum Na level reaches 130

                    meqL or neurologic symptoms are improved

                    Rapid correction of hyponatremia

                    Pontine myelinolysis

                    Seizures weaknessparesis akinetic

                    movements unresponsiveness

                    Permanent brain damage

                    Death

                    Dose

                    Na deficit meq =(140- Na meql) TBW

                    باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                    شود اصالح آهسته سپس

                    Potassium abnormalities

                    bull The average dietary intake of potassium 50-100meqd

                    bull The average renal excretion of potassium 10-700 meqd

                    - 2 of the total body potassium in ECF (45meqL)

                    - Factors that influence serum potassium

                    1 Surgical stress

                    2 Injury

                    3 Acidosis

                    4 Tissue catabolism

                    Hyperkalemia

                    The normal range of serum potassium 35-5 meqL

                    Etiology of Hyperkalemia

                    Increased intake Potassium supplementation

                    Blood transfusions

                    Endogenous loaddestruction

                    hemolysis rhabdomyolysis

                    cruch injury gastrointestinal hemorrhage

                    Increased release Acidosis

                    Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                    Renal insufficiencyfailure

                    Clinical manifestation of hyperkalemia

                    System hyperkalemia

                    Gastrointestinal Nauseavomiting colic diarrhea

                    Neuromuscular weakness paralysis respiratory failure

                    Cardiovascular Arrhythmia arrest

                    ECG changes Peaked T waves (early change)

                    Flattened P wave

                    Prolonged PR interval (first-degree block)

                    Widened QRS complex

                    Sine wave formation

                    Ventricular fibrillation

                    Treatment

                    Treatment of symptomatic hyperkalemia

                    Potassium removal Kayexalate

                    Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                    Rectal administration is 50 g in 200 mL 20 sorbitol

                    Dialysis

                    Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                    Bicarbonate 1 vial intravenous

                    Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                    HypokalemiaEtiology

                    inadequate intake

                    Dietary potassium-free intravenous fluids potassium-deficient

                    total parenteral nutrition

                    Excessive potassium excretion

                    Hyperaldosteronism

                    Medications

                    Gastrointestinal losses

                    Direct loss of potassium from gastrointestinal fluid (diarrhea)

                    Renal loss of potassium (gastric fluid either as vomiting or high

                    nasogastric output)

                    Intracellular-shift (metabolic alkalosis or insulin therapy)

                    Potassium changes associated with alkalosis

                    Potassium decrease by 03 meqL for every 01

                    increase in PH above normal

                    Magnesium Depletion

                    (drug induced amphotericin amioglycosides cisplatin)

                    Renal potassium wastage

                    Hypokalemia

                    Magnesium Depletion

                    (drug induced amphotericin amioglycosides cisplatin)

                    Renal potassium wastage

                    Hypokalemia

                    Clinical Manifestation of Abnormalities in potassium

                    System hypokalemia

                    Gastrointestinal Ileus constipation

                    Neuromuscular Decreased reflexes fatigue weakness

                    paralysis

                    Cardiovascular Arrest

                    ECG changes U-waves

                    T-wave flattening

                    ST-segment changes

                    Arrhythmias

                    Treatment

                    Potassium

                    Serum potassium level lt40 mEqL

                    Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                    times 1 doses

                    Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                    Symptomatic KC1 20 mEq IV q1h times 4 doses

                    Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                    asymptomatic replace as per above protocol

                    Electrolyte Replacement Therapy Protocol

                    bull Oral repletion for mild and asymptomatic hypokalemia

                    bull IV repletion for severe and symptomatic hypokalemia

                    Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                    ( دندانها( ndash استخوانbull كلسيم نقش

                    عصبي 1 ايمپالسهاي )NMJ(انتقال

                    صاف 2 عضالت انقباض

                    هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                    انعقاد 4

                    یونیزه Calt45 meql هيپوكلسمي

                    عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                    ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                    میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                    ( شود می پیوند شده

                    هیپوکلسمی عالئم

                    رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                    سایرعالئم

                    قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                    درمان

                    ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                    Cagt55meql هيپركلسمي

                    هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                    عالئم

                    bullGI

                    bullCardiovascular bullRenal (polyuria)

                    bullCNS

                    قلبی عالئم

                    bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                    QRS شدن )Q-Tوكوتاه

                    درمان

                    ایزوتونیک 1 نمکی محلول انفوزیون

                    الزیکس2

                    تونین 3 کلسی

                    کورتون4

                    دیالیز5

                    Magnesium Abnormalities

                    Normal dietary intake 20meq (240mg)

                    Excretion in both the feces and urine

                    Normal serum level 19-25 mgdL

                    منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                    تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                    bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                    Hypermagnesemia

                    Etiology

                    1 Impaired renal function

                    2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                    Clinical manifestation hypermanesemia

                    System hypermanesemia

                    Gastrointestinal Nauseavomiting

                    Neuromuscular weakness lethargy Decreased

                    reflexes

                    Cardiovascular Hypotension arrest

                    ECG changes Increased PR interval

                    Widened QRS complex

                    Elevated T waves

                    Treatment

                    1 Withhold exogenous sources of magnesium

                    2 Correct volume deficit

                    3 Correct acidosis if present

                    4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                    5 Dialysis (if elevated levels or symptoms persist)

                    عالئم

                    bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                    meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                    meqL

                    Hypomagnesemia

                    Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                    homeostasis

                    Etiology

                    1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                    inadequate supplementation of magnesium)

                    2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                    3 GI losses (diarrhea)

                    4 Malabsorption

                    5 Acute pancreatitis

                    6 Diabetic ketoacidosis

                    7 Primary aldosteronism

                    Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                    1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                    2 Delirium and seizures in severe deficiency

                    3 ECG changes Prolonged QT and PR interval

                    ST-segment depression

                    Flattening or inversion of P waves

                    Torsades de pointes

                    Arrhythmia

                    Treatment

                    1 For asymptomatic and mild hypomagnesemia administer oral mg

                    2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                    Message for Today

                    ICF

                    Interstitial

                    Pla

                    sma

                    5 Dex

                    bull Do not reccussitate sick patients with any Dextrose solution

                    • Fluid and Electrolyte Management of the Surgical Patient
                    • Slide 2
                    • Slide 3
                    • Slide 4
                    • Total Body Water
                    • Body Fluid Compartments
                    • Total body water (TBW)
                    • Body compartment fluid
                    • Example men with 70kg
                    • Fluid compartments
                    • Slide 11
                    • Slide 12
                    • Slide 13
                    • Slide 14
                    • Slide 15
                    • Colloid osmotic pressure
                    • Slide 17
                    • Slide 18
                    • Slide 19
                    • Cell Membrane
                    • Slide 21
                    • Slide 22
                    • Slide 23
                    • Slide 24
                    • Slide 25
                    • Composition of Fluid Compartments
                    • Composition of Body Fluids
                    • عوامل موثر روی تغییرات آب والکترولیت
                    • Reasons for fluid therapy
                    • ارزیابی حجم مایع داخل عروقی
                    • محلولهای وریدی
                    • Fluids
                    • Slide 33
                    • Slide 34
                    • Slide 35
                    • Crystalloids
                    • Colloid Solutions
                    • رینگر لاکتات
                    • 09Nacl
                    • Postoperative (maintenance)
                    • Slide 41
                    • Preexisting fluid deficits
                    • Maintenance requirements
                    • Surgical fluid losses
                    • Third space loss
                    • Crystalloid solution
                    • Colloids
                    • Complications
                    • The Influence of Colloid amp Crystalloid on Blood Volume
                    • Colloid versus crystalloid solutions
                    • Transfusion consideration
                    • اختلال در حجم مایعات بدن
                    • Fluid volume deficit (FVD)
                    • DEHYDRATION
                    • علل کاهش حجم خارج سلولی
                    • Signs of Hypovolemia
                    • Clinical Diagnosis of Hypovolemia
                    • Signs of Hypervolemia
                    • Management of Hypervolemia
                    • Fluid Management
                    • Electrolyte physiology
                    • Sodium physiology
                    • Osmotic Pressure
                    • Concentration
                    • Hypernatremia
                    • - Hypernatremia
                    • Slide 67
                    • Slide 68
                    • Clinical Manifestations of Abnormalities in Serum Sodium
                    • Treatment
                    • Water deficit (L)= times TBW
                    • The rate of fluid administration
                    • Hyponatremia Nalt135mEqL
                    • Slide 74
                    • Sodium depletion
                    • Sodium dilution
                    • Sign and symptoms
                    • Slide 78
                    • Treatment
                    • Slide 80
                    • Slide 81
                    • Dose
                    • Potassium abnormalities
                    • Hyperkalemia
                    • Clinical manifestation of hyperkalemia
                    • Slide 86
                    • Slide 87
                    • Hypokalemia
                    • Potassium changes associated with alkalosis
                    • Slide 90
                    • Clinical Manifestation of Abnormalities in potassium
                    • Slide 92
                    • Calcium
                    • هيپوكلسمي یونیزه Calt45 meql
                    • علائم هیپوکلسمی
                    • Slide 96
                    • Slide 97
                    • Slide 98
                    • Slide 99
                    • سایرعلائم
                    • درمان
                    • هيپركلسمي Cagt55meql
                    • علائم
                    • علائم قلبی
                    • Slide 105
                    • Magnesium Abnormalities
                    • منیزیوم
                    • Hypermagnesemia
                    • Clinical manifestation hypermanesemia
                    • Slide 110
                    • Slide 111
                    • Hypomagnesemia
                    • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                    • Slide 114
                    • Message for Today
                    • Slide 116

                      Fluid compartments

                      ICF

                      ECF

                      Interstitial

                      Pla

                      sma

                      Fluid compartments

                      ICF

                      ECF

                      Interstitial

                      Pla

                      sma

                      Fluid compartments

                      ICF

                      ECF

                      Interstitial

                      Pla

                      sma

                      Capillary Membrane

                      Fluid compartments

                      ICF

                      ECF

                      Interstitial

                      Pla

                      sma

                      Capillary Membrane

                      Fluid compartments

                      ICF

                      ECF

                      Interstitial

                      Pla

                      sma

                      Capillary Membrane Cell Membrane

                      Colloid osmotic pressure

                      ECF

                      Interstitial

                      Pla

                      sma

                      Capillary Membrane

                      Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                      Colloid osmotic pressure

                      ECF

                      Interstitial

                      Pla

                      sma

                      Capillary Membrane

                      Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                      Colloid osmotic pressure

                      ECF

                      Interstitial

                      Pla

                      sma

                      Capillary Membrane

                      Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                      The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                      H2O

                      H2O

                      Colloid osmotic pressure

                      ECF

                      Interstitial

                      Pla

                      sma

                      Capillary Membrane

                      Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                      The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                      This is balanced out by the hydrostatic pressure difference

                      H2O

                      H2O12080

                      H2O

                      H2O

                      Cell Membrane

                      ICF

                      Cell Membrane

                      Interstitial

                      H2O

                      H2O

                      Cell membrane is freely permeable to H20 but

                      Cell Membrane

                      ICF

                      Cell Membrane

                      Na+

                      K+

                      Interstitial

                      H2O

                      H2O

                      Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                      Cell Membrane

                      ICF

                      Cell Membrane

                      Na-

                      K+

                      Interstitial

                      H2O

                      H2O

                      Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                      [K+] =4

                      Cell Membrane

                      ICF

                      Cell Membrane

                      Na-

                      K+

                      Interstitial

                      H2O

                      H2O

                      Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                      [K+] =4 [K+] =150

                      Cell Membrane

                      ICF

                      Cell Membrane

                      Na-

                      K+

                      Interstitial

                      H2O

                      H2O

                      Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                      [K+] =4 [K+] =150

                      Na+= 144

                      Cell Membrane

                      ICF

                      Cell Membrane

                      Na-

                      K+

                      Interstitial

                      H2O

                      H2O

                      Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                      [K+] =4 [K+] =150

                      Na+= 144Na+= 10

                      Composition of Fluid Compartments

                      CATIONS ANIONS

                      Na+ 142 Cl - 103

                      HC03- 27

                      504mdash

                      3 PO4

                      ---

                      K+ 4 organicCa++ 5 Acid 5

                      Mg++ 3 Protein 16

                      CATIONS ANIONS

                      Na+ 144 Cl - 114

                      HC03- 30

                      504mdash

                      K+ 4 3 PO4

                      ---

                      organic

                      Ca++ 3 Acid 5

                      Mg++ 2 Protein 1

                      CATIONS ANIONS

                      K+ 150 HPO4

                      150 504

                      mdash

                      HCO3- 10

                      Mg++ 40 Protein 40

                      Na+ 10

                      154 mEqL 153 mEqL 153 mEqL154 mEqL

                      PLASMA INTERSTITAL FLID

                      200 mEqL 200 mEqL

                      INTRACELLULAR FLID

                      Composition of Body FluidsComposition of Body Fluids

                      Ca 2+

                      Mg 2+

                      K+

                      Na+

                      Cl-

                      PO43-

                      Organic anion

                      HCO3-

                      Protein

                      0

                      50

                      50

                      100

                      150

                      100

                      150

                      Cations Anions

                      EC

                      FICF

                      Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                      والکترولیت آب تغییرات روی موثر عوامل

                      1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                      عمل 2 از قبل والکترولیت آب وضعیت

                      اندوکرینوپاتی )3 همراه )بیماریهای

                      4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                      Reasons for fluid therapyReasons for fluid therapy

                      Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                      bull Correct hypovolaemiaCorrect hypovolaemia

                      bull Maintain cardiac outputMaintain cardiac output

                      bull Optimise gas exchangeOptimise gas exchange

                      bull Replace electrolytes amp waterReplace electrolytes amp water

                      bull Maintain urine outputMaintain urine output

                      Colloids + RBCs

                      Crystalloids

                      Identify what is the goal

                      Choose fluid which best achieves the goal

                      عروقی داخل مایع حجم ارزیابی

                      بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                      وریدی محلولهای

                      Fluids bull Crystalloids

                      bull Colloids

                      bull blood

                      Which of the following solutions is isotonic

                      A D5W

                      B 045 saline

                      C 09 saline

                      D D5 in 09 saline

                      SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                      ECFECF 142 4 5 103 27 280-310

                      Lactated Lactated RingerrsquosRingerrsquos

                      130 4 3 109 28 273

                      09 NaCl09 NaCl 154 154 308

                      045 045 NaClNaCl

                      77 77 154

                      D5WD5W

                      D5045 D5045 NaClNaCl

                      77 77 50 406

                      3 NaCl3 NaCl 513 513 1026

                      6 6 HetastarchHetastarch

                      500 154 154 310

                      5 5 AlbuminAlbumin

                      250500130-160

                      lt25130-160

                      330

                      25 25 AlbuminAlbumin

                      2050100130-160

                      lt25130-160

                      330

                      Common parenteral fluid therapyCommon parenteral fluid therapy

                      CrystalloidsCrystalloids

                      bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                      Colloid SolutionsColloid Solutions

                      bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                      - Haes-steril 10

                      الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                      کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                      ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                      osm=273

                      09Nacl

                      bull Na=154

                      bull CL= 154

                      کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                      PH=56است

                      Postoperative (maintenance)

                      045Nacl +5 dextrose +KCL

                      Perioperative management of fluid balance include

                      1 Preoperative evaluation

                      2 Intraoperative maintenance

                      3 Replacement of fluid losses

                      Preexisting fluid deficits

                      bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                      bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                      Maintenance requirements

                      bull Up to 10 kg = 4cckghr

                      bull 11-20kg = add 2cckghr

                      bull 21kg and above = add 1cckghr

                      bull Insensible losses = 2cckghr

                      Surgical fluid losses

                      Blood loss (measurement)

                      1 Suction container

                      2 Surgical sponge

                      3 Hct and tachycardia not specific

                      4 ABG and UO if hypoperfusion occur

                      5 Blood loss=31 with crystalloid

                      Other losses (third space loss)

                      Third space loss

                      1 Minimal (herniorrapy) =2-4cckghr

                      2 Moderate (cholecystectomy)=4-6cckghr

                      3 Severe (bowel resection) = 6-8cckghr

                      Crystalloid solution

                      1 The main solutions is either glucose or saline

                      2 Hypotonic or isotonic or hypertonic

                      3 Safe nontoxic reaction free inexpensive

                      4 Complication is edema if large volumes are needed

                      5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                      Colloids

                      1 Albumin

                      2 Hydroxyethyl starch

                      3 Dextran

                      Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                      factor )These colloid is best avoided in patients with

                      coagulopaty

                      The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                      1000cc

                      500cc

                      500cc

                      500cc

                      200

                      600

                      1000

                      Lactated Ringers

                      5 Albumin

                      6 Hetastarch

                      Whole blood

                      Blood volumeInfusion volume

                      Colloid versus crystalloid solutions

                      Transfusion consideration

                      bull HB lt7 mg dl increase CO

                      bull Ideal Hb is 7-8 mgdl

                      bull In IHD patients or pulmonary disease gt 10 mgdl

                      بدن مایعات حجم در اختالل

                      1 Fluid volume deficit

                      2 Fluid volume excess

                      Fluid volume deficit(FVD)

                      ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                      کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                      ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                      باشد آن با همراه دیگری اختالل مگر

                      DEHYDRATION

                      سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                      سلولی خارج حجم کاهش علل

                      1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                      2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                      کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                      Signs of HypovolemiaSigns of Hypovolemia

                      bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                      Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                      bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                      Signs of HypervolemiaSigns of Hypervolemia

                      bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                      Especially when hypo-albuminemia

                      Management of Management of HypervolemiaHypervolemia

                      bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                      Fluid ManagementFluid Management

                      bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                      Electrolyte physiology

                      Sodium physiology

                      Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                      Normal amount 135-145 meql

                      Osmotic Pressure

                      Calculated serum osmolality =

                      2 sodium+ glucose18 + BUN 28

                      Osmolality = 290 mosm

                      Concentration

                      1Serum sodium concentration2Serum osmolarity

                      bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                      drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                      DW5)

                      Hypernatremia

                      Serum Nagt145mEqL

                      - Hypernatremia

                      Loss of Free Water

                      Gain of sodium in excess of water

                      Hypernatremia

                      -Hypernatremia Hypo volemic

                      Hyper volemic

                      Normo volemic

                      Hypernatremia

                      Volume Status

                      Normal

                      Nonrenal water loss

                      Skin

                      Gastrointestinal

                      Renal water loss

                      Renal disease

                      Diuretics

                      Diabetes insipidus

                      High

                      Iatrogenic sodium administration

                      Mineralocorticoid excess

                      Aldosteronism

                      Cushingrsquos disease

                      Congenital adrenal

                      hyperplasia

                      Low

                      Nonrenal water loss

                      Skin

                      Gastrointestinal losses

                      Renal water losses

                      Renal (tubular) Diuretics

                      Osmotic diuretics

                      Diabetes insipidus

                      Adrenal failure

                      Asymptomatic

                      Hypernatremia Symptomatic (Nagt160 meqL)

                      Clinical Manifestations of Abnormalities in Serum Sodium

                      Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                      Body system hypernatremia

                      Treatment

                      Normal saline in hypovolemic patients

                      Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                      saline or entral water)

                      Water deficit (L)= times TBW

                      The formula used to estimate the amount of water required to correct hypernatremia

                      Estimate TBW as 55 of lean body mass in men and 45 in women

                      Serum sodium-140

                      140

                      The rate of fluid administration

                      1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                      2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                      Hyponatremia Nalt135mEqL

                      Causes

                      1 Sodium depletion

                      2 Sodium dilution

                      bull Incidence = 45

                      bull After surgery=1

                      bull Mortality = 2 times normal

                      Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                      volume deficit

                      Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                      Sign and symptoms

                      bull CNS symptom when Nalt123 meql

                      bull Cardiac symptom when Nalt100 meql

                      For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                      Body System Hyponatremia

                      central nervous system Headache confusion hyper-or hypoactive deep tendon

                      reflexes seizures coma increased intracranial pressure

                      Musculoskeletal Weakness fatigue muscle crampstwitching

                      Gastrointestinal Anorexia nausea vomiting watery diarrhea

                      Cardiovascular Hypertension and bradycardia if significant increases in

                      intracranial pressure

                      Tissue Lacrimation salivation

                      Renal Oliguria

                      Clinical Manifestations of Abnormalities in Serum Sodium

                      Treatment

                      1=Depend on ECF

                      2=CNS sign

                      Treatment

                      1 Asymptomatic increase the sodium level by no more than

                      05-1 meqLh to a maximum increase of 12 meqL per day

                      2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                      more than 1meqL per hour until the serum Na level reaches 130

                      meqL or neurologic symptoms are improved

                      Rapid correction of hyponatremia

                      Pontine myelinolysis

                      Seizures weaknessparesis akinetic

                      movements unresponsiveness

                      Permanent brain damage

                      Death

                      Dose

                      Na deficit meq =(140- Na meql) TBW

                      باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                      شود اصالح آهسته سپس

                      Potassium abnormalities

                      bull The average dietary intake of potassium 50-100meqd

                      bull The average renal excretion of potassium 10-700 meqd

                      - 2 of the total body potassium in ECF (45meqL)

                      - Factors that influence serum potassium

                      1 Surgical stress

                      2 Injury

                      3 Acidosis

                      4 Tissue catabolism

                      Hyperkalemia

                      The normal range of serum potassium 35-5 meqL

                      Etiology of Hyperkalemia

                      Increased intake Potassium supplementation

                      Blood transfusions

                      Endogenous loaddestruction

                      hemolysis rhabdomyolysis

                      cruch injury gastrointestinal hemorrhage

                      Increased release Acidosis

                      Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                      Renal insufficiencyfailure

                      Clinical manifestation of hyperkalemia

                      System hyperkalemia

                      Gastrointestinal Nauseavomiting colic diarrhea

                      Neuromuscular weakness paralysis respiratory failure

                      Cardiovascular Arrhythmia arrest

                      ECG changes Peaked T waves (early change)

                      Flattened P wave

                      Prolonged PR interval (first-degree block)

                      Widened QRS complex

                      Sine wave formation

                      Ventricular fibrillation

                      Treatment

                      Treatment of symptomatic hyperkalemia

                      Potassium removal Kayexalate

                      Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                      Rectal administration is 50 g in 200 mL 20 sorbitol

                      Dialysis

                      Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                      Bicarbonate 1 vial intravenous

                      Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                      HypokalemiaEtiology

                      inadequate intake

                      Dietary potassium-free intravenous fluids potassium-deficient

                      total parenteral nutrition

                      Excessive potassium excretion

                      Hyperaldosteronism

                      Medications

                      Gastrointestinal losses

                      Direct loss of potassium from gastrointestinal fluid (diarrhea)

                      Renal loss of potassium (gastric fluid either as vomiting or high

                      nasogastric output)

                      Intracellular-shift (metabolic alkalosis or insulin therapy)

                      Potassium changes associated with alkalosis

                      Potassium decrease by 03 meqL for every 01

                      increase in PH above normal

                      Magnesium Depletion

                      (drug induced amphotericin amioglycosides cisplatin)

                      Renal potassium wastage

                      Hypokalemia

                      Magnesium Depletion

                      (drug induced amphotericin amioglycosides cisplatin)

                      Renal potassium wastage

                      Hypokalemia

                      Clinical Manifestation of Abnormalities in potassium

                      System hypokalemia

                      Gastrointestinal Ileus constipation

                      Neuromuscular Decreased reflexes fatigue weakness

                      paralysis

                      Cardiovascular Arrest

                      ECG changes U-waves

                      T-wave flattening

                      ST-segment changes

                      Arrhythmias

                      Treatment

                      Potassium

                      Serum potassium level lt40 mEqL

                      Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                      times 1 doses

                      Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                      Symptomatic KC1 20 mEq IV q1h times 4 doses

                      Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                      asymptomatic replace as per above protocol

                      Electrolyte Replacement Therapy Protocol

                      bull Oral repletion for mild and asymptomatic hypokalemia

                      bull IV repletion for severe and symptomatic hypokalemia

                      Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                      ( دندانها( ndash استخوانbull كلسيم نقش

                      عصبي 1 ايمپالسهاي )NMJ(انتقال

                      صاف 2 عضالت انقباض

                      هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                      انعقاد 4

                      یونیزه Calt45 meql هيپوكلسمي

                      عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                      ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                      میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                      ( شود می پیوند شده

                      هیپوکلسمی عالئم

                      رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                      سایرعالئم

                      قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                      درمان

                      ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                      Cagt55meql هيپركلسمي

                      هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                      عالئم

                      bullGI

                      bullCardiovascular bullRenal (polyuria)

                      bullCNS

                      قلبی عالئم

                      bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                      QRS شدن )Q-Tوكوتاه

                      درمان

                      ایزوتونیک 1 نمکی محلول انفوزیون

                      الزیکس2

                      تونین 3 کلسی

                      کورتون4

                      دیالیز5

                      Magnesium Abnormalities

                      Normal dietary intake 20meq (240mg)

                      Excretion in both the feces and urine

                      Normal serum level 19-25 mgdL

                      منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                      تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                      bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                      Hypermagnesemia

                      Etiology

                      1 Impaired renal function

                      2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                      Clinical manifestation hypermanesemia

                      System hypermanesemia

                      Gastrointestinal Nauseavomiting

                      Neuromuscular weakness lethargy Decreased

                      reflexes

                      Cardiovascular Hypotension arrest

                      ECG changes Increased PR interval

                      Widened QRS complex

                      Elevated T waves

                      Treatment

                      1 Withhold exogenous sources of magnesium

                      2 Correct volume deficit

                      3 Correct acidosis if present

                      4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                      5 Dialysis (if elevated levels or symptoms persist)

                      عالئم

                      bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                      meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                      meqL

                      Hypomagnesemia

                      Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                      homeostasis

                      Etiology

                      1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                      inadequate supplementation of magnesium)

                      2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                      3 GI losses (diarrhea)

                      4 Malabsorption

                      5 Acute pancreatitis

                      6 Diabetic ketoacidosis

                      7 Primary aldosteronism

                      Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                      1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                      2 Delirium and seizures in severe deficiency

                      3 ECG changes Prolonged QT and PR interval

                      ST-segment depression

                      Flattening or inversion of P waves

                      Torsades de pointes

                      Arrhythmia

                      Treatment

                      1 For asymptomatic and mild hypomagnesemia administer oral mg

                      2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                      Message for Today

                      ICF

                      Interstitial

                      Pla

                      sma

                      5 Dex

                      bull Do not reccussitate sick patients with any Dextrose solution

                      • Fluid and Electrolyte Management of the Surgical Patient
                      • Slide 2
                      • Slide 3
                      • Slide 4
                      • Total Body Water
                      • Body Fluid Compartments
                      • Total body water (TBW)
                      • Body compartment fluid
                      • Example men with 70kg
                      • Fluid compartments
                      • Slide 11
                      • Slide 12
                      • Slide 13
                      • Slide 14
                      • Slide 15
                      • Colloid osmotic pressure
                      • Slide 17
                      • Slide 18
                      • Slide 19
                      • Cell Membrane
                      • Slide 21
                      • Slide 22
                      • Slide 23
                      • Slide 24
                      • Slide 25
                      • Composition of Fluid Compartments
                      • Composition of Body Fluids
                      • عوامل موثر روی تغییرات آب والکترولیت
                      • Reasons for fluid therapy
                      • ارزیابی حجم مایع داخل عروقی
                      • محلولهای وریدی
                      • Fluids
                      • Slide 33
                      • Slide 34
                      • Slide 35
                      • Crystalloids
                      • Colloid Solutions
                      • رینگر لاکتات
                      • 09Nacl
                      • Postoperative (maintenance)
                      • Slide 41
                      • Preexisting fluid deficits
                      • Maintenance requirements
                      • Surgical fluid losses
                      • Third space loss
                      • Crystalloid solution
                      • Colloids
                      • Complications
                      • The Influence of Colloid amp Crystalloid on Blood Volume
                      • Colloid versus crystalloid solutions
                      • Transfusion consideration
                      • اختلال در حجم مایعات بدن
                      • Fluid volume deficit (FVD)
                      • DEHYDRATION
                      • علل کاهش حجم خارج سلولی
                      • Signs of Hypovolemia
                      • Clinical Diagnosis of Hypovolemia
                      • Signs of Hypervolemia
                      • Management of Hypervolemia
                      • Fluid Management
                      • Electrolyte physiology
                      • Sodium physiology
                      • Osmotic Pressure
                      • Concentration
                      • Hypernatremia
                      • - Hypernatremia
                      • Slide 67
                      • Slide 68
                      • Clinical Manifestations of Abnormalities in Serum Sodium
                      • Treatment
                      • Water deficit (L)= times TBW
                      • The rate of fluid administration
                      • Hyponatremia Nalt135mEqL
                      • Slide 74
                      • Sodium depletion
                      • Sodium dilution
                      • Sign and symptoms
                      • Slide 78
                      • Treatment
                      • Slide 80
                      • Slide 81
                      • Dose
                      • Potassium abnormalities
                      • Hyperkalemia
                      • Clinical manifestation of hyperkalemia
                      • Slide 86
                      • Slide 87
                      • Hypokalemia
                      • Potassium changes associated with alkalosis
                      • Slide 90
                      • Clinical Manifestation of Abnormalities in potassium
                      • Slide 92
                      • Calcium
                      • هيپوكلسمي یونیزه Calt45 meql
                      • علائم هیپوکلسمی
                      • Slide 96
                      • Slide 97
                      • Slide 98
                      • Slide 99
                      • سایرعلائم
                      • درمان
                      • هيپركلسمي Cagt55meql
                      • علائم
                      • علائم قلبی
                      • Slide 105
                      • Magnesium Abnormalities
                      • منیزیوم
                      • Hypermagnesemia
                      • Clinical manifestation hypermanesemia
                      • Slide 110
                      • Slide 111
                      • Hypomagnesemia
                      • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                      • Slide 114
                      • Message for Today
                      • Slide 116

                        Fluid compartments

                        ICF

                        ECF

                        Interstitial

                        Pla

                        sma

                        Fluid compartments

                        ICF

                        ECF

                        Interstitial

                        Pla

                        sma

                        Capillary Membrane

                        Fluid compartments

                        ICF

                        ECF

                        Interstitial

                        Pla

                        sma

                        Capillary Membrane

                        Fluid compartments

                        ICF

                        ECF

                        Interstitial

                        Pla

                        sma

                        Capillary Membrane Cell Membrane

                        Colloid osmotic pressure

                        ECF

                        Interstitial

                        Pla

                        sma

                        Capillary Membrane

                        Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                        Colloid osmotic pressure

                        ECF

                        Interstitial

                        Pla

                        sma

                        Capillary Membrane

                        Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                        Colloid osmotic pressure

                        ECF

                        Interstitial

                        Pla

                        sma

                        Capillary Membrane

                        Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                        The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                        H2O

                        H2O

                        Colloid osmotic pressure

                        ECF

                        Interstitial

                        Pla

                        sma

                        Capillary Membrane

                        Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                        The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                        This is balanced out by the hydrostatic pressure difference

                        H2O

                        H2O12080

                        H2O

                        H2O

                        Cell Membrane

                        ICF

                        Cell Membrane

                        Interstitial

                        H2O

                        H2O

                        Cell membrane is freely permeable to H20 but

                        Cell Membrane

                        ICF

                        Cell Membrane

                        Na+

                        K+

                        Interstitial

                        H2O

                        H2O

                        Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                        Cell Membrane

                        ICF

                        Cell Membrane

                        Na-

                        K+

                        Interstitial

                        H2O

                        H2O

                        Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                        [K+] =4

                        Cell Membrane

                        ICF

                        Cell Membrane

                        Na-

                        K+

                        Interstitial

                        H2O

                        H2O

                        Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                        [K+] =4 [K+] =150

                        Cell Membrane

                        ICF

                        Cell Membrane

                        Na-

                        K+

                        Interstitial

                        H2O

                        H2O

                        Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                        [K+] =4 [K+] =150

                        Na+= 144

                        Cell Membrane

                        ICF

                        Cell Membrane

                        Na-

                        K+

                        Interstitial

                        H2O

                        H2O

                        Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                        [K+] =4 [K+] =150

                        Na+= 144Na+= 10

                        Composition of Fluid Compartments

                        CATIONS ANIONS

                        Na+ 142 Cl - 103

                        HC03- 27

                        504mdash

                        3 PO4

                        ---

                        K+ 4 organicCa++ 5 Acid 5

                        Mg++ 3 Protein 16

                        CATIONS ANIONS

                        Na+ 144 Cl - 114

                        HC03- 30

                        504mdash

                        K+ 4 3 PO4

                        ---

                        organic

                        Ca++ 3 Acid 5

                        Mg++ 2 Protein 1

                        CATIONS ANIONS

                        K+ 150 HPO4

                        150 504

                        mdash

                        HCO3- 10

                        Mg++ 40 Protein 40

                        Na+ 10

                        154 mEqL 153 mEqL 153 mEqL154 mEqL

                        PLASMA INTERSTITAL FLID

                        200 mEqL 200 mEqL

                        INTRACELLULAR FLID

                        Composition of Body FluidsComposition of Body Fluids

                        Ca 2+

                        Mg 2+

                        K+

                        Na+

                        Cl-

                        PO43-

                        Organic anion

                        HCO3-

                        Protein

                        0

                        50

                        50

                        100

                        150

                        100

                        150

                        Cations Anions

                        EC

                        FICF

                        Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                        والکترولیت آب تغییرات روی موثر عوامل

                        1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                        عمل 2 از قبل والکترولیت آب وضعیت

                        اندوکرینوپاتی )3 همراه )بیماریهای

                        4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                        Reasons for fluid therapyReasons for fluid therapy

                        Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                        bull Correct hypovolaemiaCorrect hypovolaemia

                        bull Maintain cardiac outputMaintain cardiac output

                        bull Optimise gas exchangeOptimise gas exchange

                        bull Replace electrolytes amp waterReplace electrolytes amp water

                        bull Maintain urine outputMaintain urine output

                        Colloids + RBCs

                        Crystalloids

                        Identify what is the goal

                        Choose fluid which best achieves the goal

                        عروقی داخل مایع حجم ارزیابی

                        بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                        وریدی محلولهای

                        Fluids bull Crystalloids

                        bull Colloids

                        bull blood

                        Which of the following solutions is isotonic

                        A D5W

                        B 045 saline

                        C 09 saline

                        D D5 in 09 saline

                        SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                        ECFECF 142 4 5 103 27 280-310

                        Lactated Lactated RingerrsquosRingerrsquos

                        130 4 3 109 28 273

                        09 NaCl09 NaCl 154 154 308

                        045 045 NaClNaCl

                        77 77 154

                        D5WD5W

                        D5045 D5045 NaClNaCl

                        77 77 50 406

                        3 NaCl3 NaCl 513 513 1026

                        6 6 HetastarchHetastarch

                        500 154 154 310

                        5 5 AlbuminAlbumin

                        250500130-160

                        lt25130-160

                        330

                        25 25 AlbuminAlbumin

                        2050100130-160

                        lt25130-160

                        330

                        Common parenteral fluid therapyCommon parenteral fluid therapy

                        CrystalloidsCrystalloids

                        bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                        Colloid SolutionsColloid Solutions

                        bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                        - Haes-steril 10

                        الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                        کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                        ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                        osm=273

                        09Nacl

                        bull Na=154

                        bull CL= 154

                        کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                        PH=56است

                        Postoperative (maintenance)

                        045Nacl +5 dextrose +KCL

                        Perioperative management of fluid balance include

                        1 Preoperative evaluation

                        2 Intraoperative maintenance

                        3 Replacement of fluid losses

                        Preexisting fluid deficits

                        bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                        bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                        Maintenance requirements

                        bull Up to 10 kg = 4cckghr

                        bull 11-20kg = add 2cckghr

                        bull 21kg and above = add 1cckghr

                        bull Insensible losses = 2cckghr

                        Surgical fluid losses

                        Blood loss (measurement)

                        1 Suction container

                        2 Surgical sponge

                        3 Hct and tachycardia not specific

                        4 ABG and UO if hypoperfusion occur

                        5 Blood loss=31 with crystalloid

                        Other losses (third space loss)

                        Third space loss

                        1 Minimal (herniorrapy) =2-4cckghr

                        2 Moderate (cholecystectomy)=4-6cckghr

                        3 Severe (bowel resection) = 6-8cckghr

                        Crystalloid solution

                        1 The main solutions is either glucose or saline

                        2 Hypotonic or isotonic or hypertonic

                        3 Safe nontoxic reaction free inexpensive

                        4 Complication is edema if large volumes are needed

                        5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                        Colloids

                        1 Albumin

                        2 Hydroxyethyl starch

                        3 Dextran

                        Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                        factor )These colloid is best avoided in patients with

                        coagulopaty

                        The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                        1000cc

                        500cc

                        500cc

                        500cc

                        200

                        600

                        1000

                        Lactated Ringers

                        5 Albumin

                        6 Hetastarch

                        Whole blood

                        Blood volumeInfusion volume

                        Colloid versus crystalloid solutions

                        Transfusion consideration

                        bull HB lt7 mg dl increase CO

                        bull Ideal Hb is 7-8 mgdl

                        bull In IHD patients or pulmonary disease gt 10 mgdl

                        بدن مایعات حجم در اختالل

                        1 Fluid volume deficit

                        2 Fluid volume excess

                        Fluid volume deficit(FVD)

                        ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                        کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                        ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                        باشد آن با همراه دیگری اختالل مگر

                        DEHYDRATION

                        سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                        سلولی خارج حجم کاهش علل

                        1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                        2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                        کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                        Signs of HypovolemiaSigns of Hypovolemia

                        bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                        Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                        bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                        Signs of HypervolemiaSigns of Hypervolemia

                        bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                        Especially when hypo-albuminemia

                        Management of Management of HypervolemiaHypervolemia

                        bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                        Fluid ManagementFluid Management

                        bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                        Electrolyte physiology

                        Sodium physiology

                        Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                        Normal amount 135-145 meql

                        Osmotic Pressure

                        Calculated serum osmolality =

                        2 sodium+ glucose18 + BUN 28

                        Osmolality = 290 mosm

                        Concentration

                        1Serum sodium concentration2Serum osmolarity

                        bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                        drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                        DW5)

                        Hypernatremia

                        Serum Nagt145mEqL

                        - Hypernatremia

                        Loss of Free Water

                        Gain of sodium in excess of water

                        Hypernatremia

                        -Hypernatremia Hypo volemic

                        Hyper volemic

                        Normo volemic

                        Hypernatremia

                        Volume Status

                        Normal

                        Nonrenal water loss

                        Skin

                        Gastrointestinal

                        Renal water loss

                        Renal disease

                        Diuretics

                        Diabetes insipidus

                        High

                        Iatrogenic sodium administration

                        Mineralocorticoid excess

                        Aldosteronism

                        Cushingrsquos disease

                        Congenital adrenal

                        hyperplasia

                        Low

                        Nonrenal water loss

                        Skin

                        Gastrointestinal losses

                        Renal water losses

                        Renal (tubular) Diuretics

                        Osmotic diuretics

                        Diabetes insipidus

                        Adrenal failure

                        Asymptomatic

                        Hypernatremia Symptomatic (Nagt160 meqL)

                        Clinical Manifestations of Abnormalities in Serum Sodium

                        Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                        Body system hypernatremia

                        Treatment

                        Normal saline in hypovolemic patients

                        Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                        saline or entral water)

                        Water deficit (L)= times TBW

                        The formula used to estimate the amount of water required to correct hypernatremia

                        Estimate TBW as 55 of lean body mass in men and 45 in women

                        Serum sodium-140

                        140

                        The rate of fluid administration

                        1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                        2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                        Hyponatremia Nalt135mEqL

                        Causes

                        1 Sodium depletion

                        2 Sodium dilution

                        bull Incidence = 45

                        bull After surgery=1

                        bull Mortality = 2 times normal

                        Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                        volume deficit

                        Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                        Sign and symptoms

                        bull CNS symptom when Nalt123 meql

                        bull Cardiac symptom when Nalt100 meql

                        For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                        Body System Hyponatremia

                        central nervous system Headache confusion hyper-or hypoactive deep tendon

                        reflexes seizures coma increased intracranial pressure

                        Musculoskeletal Weakness fatigue muscle crampstwitching

                        Gastrointestinal Anorexia nausea vomiting watery diarrhea

                        Cardiovascular Hypertension and bradycardia if significant increases in

                        intracranial pressure

                        Tissue Lacrimation salivation

                        Renal Oliguria

                        Clinical Manifestations of Abnormalities in Serum Sodium

                        Treatment

                        1=Depend on ECF

                        2=CNS sign

                        Treatment

                        1 Asymptomatic increase the sodium level by no more than

                        05-1 meqLh to a maximum increase of 12 meqL per day

                        2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                        more than 1meqL per hour until the serum Na level reaches 130

                        meqL or neurologic symptoms are improved

                        Rapid correction of hyponatremia

                        Pontine myelinolysis

                        Seizures weaknessparesis akinetic

                        movements unresponsiveness

                        Permanent brain damage

                        Death

                        Dose

                        Na deficit meq =(140- Na meql) TBW

                        باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                        شود اصالح آهسته سپس

                        Potassium abnormalities

                        bull The average dietary intake of potassium 50-100meqd

                        bull The average renal excretion of potassium 10-700 meqd

                        - 2 of the total body potassium in ECF (45meqL)

                        - Factors that influence serum potassium

                        1 Surgical stress

                        2 Injury

                        3 Acidosis

                        4 Tissue catabolism

                        Hyperkalemia

                        The normal range of serum potassium 35-5 meqL

                        Etiology of Hyperkalemia

                        Increased intake Potassium supplementation

                        Blood transfusions

                        Endogenous loaddestruction

                        hemolysis rhabdomyolysis

                        cruch injury gastrointestinal hemorrhage

                        Increased release Acidosis

                        Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                        Renal insufficiencyfailure

                        Clinical manifestation of hyperkalemia

                        System hyperkalemia

                        Gastrointestinal Nauseavomiting colic diarrhea

                        Neuromuscular weakness paralysis respiratory failure

                        Cardiovascular Arrhythmia arrest

                        ECG changes Peaked T waves (early change)

                        Flattened P wave

                        Prolonged PR interval (first-degree block)

                        Widened QRS complex

                        Sine wave formation

                        Ventricular fibrillation

                        Treatment

                        Treatment of symptomatic hyperkalemia

                        Potassium removal Kayexalate

                        Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                        Rectal administration is 50 g in 200 mL 20 sorbitol

                        Dialysis

                        Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                        Bicarbonate 1 vial intravenous

                        Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                        HypokalemiaEtiology

                        inadequate intake

                        Dietary potassium-free intravenous fluids potassium-deficient

                        total parenteral nutrition

                        Excessive potassium excretion

                        Hyperaldosteronism

                        Medications

                        Gastrointestinal losses

                        Direct loss of potassium from gastrointestinal fluid (diarrhea)

                        Renal loss of potassium (gastric fluid either as vomiting or high

                        nasogastric output)

                        Intracellular-shift (metabolic alkalosis or insulin therapy)

                        Potassium changes associated with alkalosis

                        Potassium decrease by 03 meqL for every 01

                        increase in PH above normal

                        Magnesium Depletion

                        (drug induced amphotericin amioglycosides cisplatin)

                        Renal potassium wastage

                        Hypokalemia

                        Magnesium Depletion

                        (drug induced amphotericin amioglycosides cisplatin)

                        Renal potassium wastage

                        Hypokalemia

                        Clinical Manifestation of Abnormalities in potassium

                        System hypokalemia

                        Gastrointestinal Ileus constipation

                        Neuromuscular Decreased reflexes fatigue weakness

                        paralysis

                        Cardiovascular Arrest

                        ECG changes U-waves

                        T-wave flattening

                        ST-segment changes

                        Arrhythmias

                        Treatment

                        Potassium

                        Serum potassium level lt40 mEqL

                        Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                        times 1 doses

                        Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                        Symptomatic KC1 20 mEq IV q1h times 4 doses

                        Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                        asymptomatic replace as per above protocol

                        Electrolyte Replacement Therapy Protocol

                        bull Oral repletion for mild and asymptomatic hypokalemia

                        bull IV repletion for severe and symptomatic hypokalemia

                        Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                        ( دندانها( ndash استخوانbull كلسيم نقش

                        عصبي 1 ايمپالسهاي )NMJ(انتقال

                        صاف 2 عضالت انقباض

                        هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                        انعقاد 4

                        یونیزه Calt45 meql هيپوكلسمي

                        عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                        ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                        میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                        ( شود می پیوند شده

                        هیپوکلسمی عالئم

                        رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                        سایرعالئم

                        قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                        درمان

                        ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                        Cagt55meql هيپركلسمي

                        هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                        عالئم

                        bullGI

                        bullCardiovascular bullRenal (polyuria)

                        bullCNS

                        قلبی عالئم

                        bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                        QRS شدن )Q-Tوكوتاه

                        درمان

                        ایزوتونیک 1 نمکی محلول انفوزیون

                        الزیکس2

                        تونین 3 کلسی

                        کورتون4

                        دیالیز5

                        Magnesium Abnormalities

                        Normal dietary intake 20meq (240mg)

                        Excretion in both the feces and urine

                        Normal serum level 19-25 mgdL

                        منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                        تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                        bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                        Hypermagnesemia

                        Etiology

                        1 Impaired renal function

                        2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                        Clinical manifestation hypermanesemia

                        System hypermanesemia

                        Gastrointestinal Nauseavomiting

                        Neuromuscular weakness lethargy Decreased

                        reflexes

                        Cardiovascular Hypotension arrest

                        ECG changes Increased PR interval

                        Widened QRS complex

                        Elevated T waves

                        Treatment

                        1 Withhold exogenous sources of magnesium

                        2 Correct volume deficit

                        3 Correct acidosis if present

                        4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                        5 Dialysis (if elevated levels or symptoms persist)

                        عالئم

                        bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                        meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                        meqL

                        Hypomagnesemia

                        Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                        homeostasis

                        Etiology

                        1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                        inadequate supplementation of magnesium)

                        2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                        3 GI losses (diarrhea)

                        4 Malabsorption

                        5 Acute pancreatitis

                        6 Diabetic ketoacidosis

                        7 Primary aldosteronism

                        Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                        1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                        2 Delirium and seizures in severe deficiency

                        3 ECG changes Prolonged QT and PR interval

                        ST-segment depression

                        Flattening or inversion of P waves

                        Torsades de pointes

                        Arrhythmia

                        Treatment

                        1 For asymptomatic and mild hypomagnesemia administer oral mg

                        2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                        Message for Today

                        ICF

                        Interstitial

                        Pla

                        sma

                        5 Dex

                        bull Do not reccussitate sick patients with any Dextrose solution

                        • Fluid and Electrolyte Management of the Surgical Patient
                        • Slide 2
                        • Slide 3
                        • Slide 4
                        • Total Body Water
                        • Body Fluid Compartments
                        • Total body water (TBW)
                        • Body compartment fluid
                        • Example men with 70kg
                        • Fluid compartments
                        • Slide 11
                        • Slide 12
                        • Slide 13
                        • Slide 14
                        • Slide 15
                        • Colloid osmotic pressure
                        • Slide 17
                        • Slide 18
                        • Slide 19
                        • Cell Membrane
                        • Slide 21
                        • Slide 22
                        • Slide 23
                        • Slide 24
                        • Slide 25
                        • Composition of Fluid Compartments
                        • Composition of Body Fluids
                        • عوامل موثر روی تغییرات آب والکترولیت
                        • Reasons for fluid therapy
                        • ارزیابی حجم مایع داخل عروقی
                        • محلولهای وریدی
                        • Fluids
                        • Slide 33
                        • Slide 34
                        • Slide 35
                        • Crystalloids
                        • Colloid Solutions
                        • رینگر لاکتات
                        • 09Nacl
                        • Postoperative (maintenance)
                        • Slide 41
                        • Preexisting fluid deficits
                        • Maintenance requirements
                        • Surgical fluid losses
                        • Third space loss
                        • Crystalloid solution
                        • Colloids
                        • Complications
                        • The Influence of Colloid amp Crystalloid on Blood Volume
                        • Colloid versus crystalloid solutions
                        • Transfusion consideration
                        • اختلال در حجم مایعات بدن
                        • Fluid volume deficit (FVD)
                        • DEHYDRATION
                        • علل کاهش حجم خارج سلولی
                        • Signs of Hypovolemia
                        • Clinical Diagnosis of Hypovolemia
                        • Signs of Hypervolemia
                        • Management of Hypervolemia
                        • Fluid Management
                        • Electrolyte physiology
                        • Sodium physiology
                        • Osmotic Pressure
                        • Concentration
                        • Hypernatremia
                        • - Hypernatremia
                        • Slide 67
                        • Slide 68
                        • Clinical Manifestations of Abnormalities in Serum Sodium
                        • Treatment
                        • Water deficit (L)= times TBW
                        • The rate of fluid administration
                        • Hyponatremia Nalt135mEqL
                        • Slide 74
                        • Sodium depletion
                        • Sodium dilution
                        • Sign and symptoms
                        • Slide 78
                        • Treatment
                        • Slide 80
                        • Slide 81
                        • Dose
                        • Potassium abnormalities
                        • Hyperkalemia
                        • Clinical manifestation of hyperkalemia
                        • Slide 86
                        • Slide 87
                        • Hypokalemia
                        • Potassium changes associated with alkalosis
                        • Slide 90
                        • Clinical Manifestation of Abnormalities in potassium
                        • Slide 92
                        • Calcium
                        • هيپوكلسمي یونیزه Calt45 meql
                        • علائم هیپوکلسمی
                        • Slide 96
                        • Slide 97
                        • Slide 98
                        • Slide 99
                        • سایرعلائم
                        • درمان
                        • هيپركلسمي Cagt55meql
                        • علائم
                        • علائم قلبی
                        • Slide 105
                        • Magnesium Abnormalities
                        • منیزیوم
                        • Hypermagnesemia
                        • Clinical manifestation hypermanesemia
                        • Slide 110
                        • Slide 111
                        • Hypomagnesemia
                        • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                        • Slide 114
                        • Message for Today
                        • Slide 116

                          Fluid compartments

                          ICF

                          ECF

                          Interstitial

                          Pla

                          sma

                          Capillary Membrane

                          Fluid compartments

                          ICF

                          ECF

                          Interstitial

                          Pla

                          sma

                          Capillary Membrane

                          Fluid compartments

                          ICF

                          ECF

                          Interstitial

                          Pla

                          sma

                          Capillary Membrane Cell Membrane

                          Colloid osmotic pressure

                          ECF

                          Interstitial

                          Pla

                          sma

                          Capillary Membrane

                          Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                          Colloid osmotic pressure

                          ECF

                          Interstitial

                          Pla

                          sma

                          Capillary Membrane

                          Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                          Colloid osmotic pressure

                          ECF

                          Interstitial

                          Pla

                          sma

                          Capillary Membrane

                          Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                          The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                          H2O

                          H2O

                          Colloid osmotic pressure

                          ECF

                          Interstitial

                          Pla

                          sma

                          Capillary Membrane

                          Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                          The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                          This is balanced out by the hydrostatic pressure difference

                          H2O

                          H2O12080

                          H2O

                          H2O

                          Cell Membrane

                          ICF

                          Cell Membrane

                          Interstitial

                          H2O

                          H2O

                          Cell membrane is freely permeable to H20 but

                          Cell Membrane

                          ICF

                          Cell Membrane

                          Na+

                          K+

                          Interstitial

                          H2O

                          H2O

                          Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                          Cell Membrane

                          ICF

                          Cell Membrane

                          Na-

                          K+

                          Interstitial

                          H2O

                          H2O

                          Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                          [K+] =4

                          Cell Membrane

                          ICF

                          Cell Membrane

                          Na-

                          K+

                          Interstitial

                          H2O

                          H2O

                          Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                          [K+] =4 [K+] =150

                          Cell Membrane

                          ICF

                          Cell Membrane

                          Na-

                          K+

                          Interstitial

                          H2O

                          H2O

                          Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                          [K+] =4 [K+] =150

                          Na+= 144

                          Cell Membrane

                          ICF

                          Cell Membrane

                          Na-

                          K+

                          Interstitial

                          H2O

                          H2O

                          Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                          [K+] =4 [K+] =150

                          Na+= 144Na+= 10

                          Composition of Fluid Compartments

                          CATIONS ANIONS

                          Na+ 142 Cl - 103

                          HC03- 27

                          504mdash

                          3 PO4

                          ---

                          K+ 4 organicCa++ 5 Acid 5

                          Mg++ 3 Protein 16

                          CATIONS ANIONS

                          Na+ 144 Cl - 114

                          HC03- 30

                          504mdash

                          K+ 4 3 PO4

                          ---

                          organic

                          Ca++ 3 Acid 5

                          Mg++ 2 Protein 1

                          CATIONS ANIONS

                          K+ 150 HPO4

                          150 504

                          mdash

                          HCO3- 10

                          Mg++ 40 Protein 40

                          Na+ 10

                          154 mEqL 153 mEqL 153 mEqL154 mEqL

                          PLASMA INTERSTITAL FLID

                          200 mEqL 200 mEqL

                          INTRACELLULAR FLID

                          Composition of Body FluidsComposition of Body Fluids

                          Ca 2+

                          Mg 2+

                          K+

                          Na+

                          Cl-

                          PO43-

                          Organic anion

                          HCO3-

                          Protein

                          0

                          50

                          50

                          100

                          150

                          100

                          150

                          Cations Anions

                          EC

                          FICF

                          Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                          والکترولیت آب تغییرات روی موثر عوامل

                          1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                          عمل 2 از قبل والکترولیت آب وضعیت

                          اندوکرینوپاتی )3 همراه )بیماریهای

                          4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                          Reasons for fluid therapyReasons for fluid therapy

                          Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                          bull Correct hypovolaemiaCorrect hypovolaemia

                          bull Maintain cardiac outputMaintain cardiac output

                          bull Optimise gas exchangeOptimise gas exchange

                          bull Replace electrolytes amp waterReplace electrolytes amp water

                          bull Maintain urine outputMaintain urine output

                          Colloids + RBCs

                          Crystalloids

                          Identify what is the goal

                          Choose fluid which best achieves the goal

                          عروقی داخل مایع حجم ارزیابی

                          بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                          وریدی محلولهای

                          Fluids bull Crystalloids

                          bull Colloids

                          bull blood

                          Which of the following solutions is isotonic

                          A D5W

                          B 045 saline

                          C 09 saline

                          D D5 in 09 saline

                          SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                          ECFECF 142 4 5 103 27 280-310

                          Lactated Lactated RingerrsquosRingerrsquos

                          130 4 3 109 28 273

                          09 NaCl09 NaCl 154 154 308

                          045 045 NaClNaCl

                          77 77 154

                          D5WD5W

                          D5045 D5045 NaClNaCl

                          77 77 50 406

                          3 NaCl3 NaCl 513 513 1026

                          6 6 HetastarchHetastarch

                          500 154 154 310

                          5 5 AlbuminAlbumin

                          250500130-160

                          lt25130-160

                          330

                          25 25 AlbuminAlbumin

                          2050100130-160

                          lt25130-160

                          330

                          Common parenteral fluid therapyCommon parenteral fluid therapy

                          CrystalloidsCrystalloids

                          bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                          Colloid SolutionsColloid Solutions

                          bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                          - Haes-steril 10

                          الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                          کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                          ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                          osm=273

                          09Nacl

                          bull Na=154

                          bull CL= 154

                          کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                          PH=56است

                          Postoperative (maintenance)

                          045Nacl +5 dextrose +KCL

                          Perioperative management of fluid balance include

                          1 Preoperative evaluation

                          2 Intraoperative maintenance

                          3 Replacement of fluid losses

                          Preexisting fluid deficits

                          bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                          bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                          Maintenance requirements

                          bull Up to 10 kg = 4cckghr

                          bull 11-20kg = add 2cckghr

                          bull 21kg and above = add 1cckghr

                          bull Insensible losses = 2cckghr

                          Surgical fluid losses

                          Blood loss (measurement)

                          1 Suction container

                          2 Surgical sponge

                          3 Hct and tachycardia not specific

                          4 ABG and UO if hypoperfusion occur

                          5 Blood loss=31 with crystalloid

                          Other losses (third space loss)

                          Third space loss

                          1 Minimal (herniorrapy) =2-4cckghr

                          2 Moderate (cholecystectomy)=4-6cckghr

                          3 Severe (bowel resection) = 6-8cckghr

                          Crystalloid solution

                          1 The main solutions is either glucose or saline

                          2 Hypotonic or isotonic or hypertonic

                          3 Safe nontoxic reaction free inexpensive

                          4 Complication is edema if large volumes are needed

                          5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                          Colloids

                          1 Albumin

                          2 Hydroxyethyl starch

                          3 Dextran

                          Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                          factor )These colloid is best avoided in patients with

                          coagulopaty

                          The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                          1000cc

                          500cc

                          500cc

                          500cc

                          200

                          600

                          1000

                          Lactated Ringers

                          5 Albumin

                          6 Hetastarch

                          Whole blood

                          Blood volumeInfusion volume

                          Colloid versus crystalloid solutions

                          Transfusion consideration

                          bull HB lt7 mg dl increase CO

                          bull Ideal Hb is 7-8 mgdl

                          bull In IHD patients or pulmonary disease gt 10 mgdl

                          بدن مایعات حجم در اختالل

                          1 Fluid volume deficit

                          2 Fluid volume excess

                          Fluid volume deficit(FVD)

                          ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                          کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                          ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                          باشد آن با همراه دیگری اختالل مگر

                          DEHYDRATION

                          سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                          سلولی خارج حجم کاهش علل

                          1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                          2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                          کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                          Signs of HypovolemiaSigns of Hypovolemia

                          bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                          Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                          bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                          Signs of HypervolemiaSigns of Hypervolemia

                          bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                          Especially when hypo-albuminemia

                          Management of Management of HypervolemiaHypervolemia

                          bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                          Fluid ManagementFluid Management

                          bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                          Electrolyte physiology

                          Sodium physiology

                          Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                          Normal amount 135-145 meql

                          Osmotic Pressure

                          Calculated serum osmolality =

                          2 sodium+ glucose18 + BUN 28

                          Osmolality = 290 mosm

                          Concentration

                          1Serum sodium concentration2Serum osmolarity

                          bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                          drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                          DW5)

                          Hypernatremia

                          Serum Nagt145mEqL

                          - Hypernatremia

                          Loss of Free Water

                          Gain of sodium in excess of water

                          Hypernatremia

                          -Hypernatremia Hypo volemic

                          Hyper volemic

                          Normo volemic

                          Hypernatremia

                          Volume Status

                          Normal

                          Nonrenal water loss

                          Skin

                          Gastrointestinal

                          Renal water loss

                          Renal disease

                          Diuretics

                          Diabetes insipidus

                          High

                          Iatrogenic sodium administration

                          Mineralocorticoid excess

                          Aldosteronism

                          Cushingrsquos disease

                          Congenital adrenal

                          hyperplasia

                          Low

                          Nonrenal water loss

                          Skin

                          Gastrointestinal losses

                          Renal water losses

                          Renal (tubular) Diuretics

                          Osmotic diuretics

                          Diabetes insipidus

                          Adrenal failure

                          Asymptomatic

                          Hypernatremia Symptomatic (Nagt160 meqL)

                          Clinical Manifestations of Abnormalities in Serum Sodium

                          Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                          Body system hypernatremia

                          Treatment

                          Normal saline in hypovolemic patients

                          Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                          saline or entral water)

                          Water deficit (L)= times TBW

                          The formula used to estimate the amount of water required to correct hypernatremia

                          Estimate TBW as 55 of lean body mass in men and 45 in women

                          Serum sodium-140

                          140

                          The rate of fluid administration

                          1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                          2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                          Hyponatremia Nalt135mEqL

                          Causes

                          1 Sodium depletion

                          2 Sodium dilution

                          bull Incidence = 45

                          bull After surgery=1

                          bull Mortality = 2 times normal

                          Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                          volume deficit

                          Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                          Sign and symptoms

                          bull CNS symptom when Nalt123 meql

                          bull Cardiac symptom when Nalt100 meql

                          For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                          Body System Hyponatremia

                          central nervous system Headache confusion hyper-or hypoactive deep tendon

                          reflexes seizures coma increased intracranial pressure

                          Musculoskeletal Weakness fatigue muscle crampstwitching

                          Gastrointestinal Anorexia nausea vomiting watery diarrhea

                          Cardiovascular Hypertension and bradycardia if significant increases in

                          intracranial pressure

                          Tissue Lacrimation salivation

                          Renal Oliguria

                          Clinical Manifestations of Abnormalities in Serum Sodium

                          Treatment

                          1=Depend on ECF

                          2=CNS sign

                          Treatment

                          1 Asymptomatic increase the sodium level by no more than

                          05-1 meqLh to a maximum increase of 12 meqL per day

                          2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                          more than 1meqL per hour until the serum Na level reaches 130

                          meqL or neurologic symptoms are improved

                          Rapid correction of hyponatremia

                          Pontine myelinolysis

                          Seizures weaknessparesis akinetic

                          movements unresponsiveness

                          Permanent brain damage

                          Death

                          Dose

                          Na deficit meq =(140- Na meql) TBW

                          باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                          شود اصالح آهسته سپس

                          Potassium abnormalities

                          bull The average dietary intake of potassium 50-100meqd

                          bull The average renal excretion of potassium 10-700 meqd

                          - 2 of the total body potassium in ECF (45meqL)

                          - Factors that influence serum potassium

                          1 Surgical stress

                          2 Injury

                          3 Acidosis

                          4 Tissue catabolism

                          Hyperkalemia

                          The normal range of serum potassium 35-5 meqL

                          Etiology of Hyperkalemia

                          Increased intake Potassium supplementation

                          Blood transfusions

                          Endogenous loaddestruction

                          hemolysis rhabdomyolysis

                          cruch injury gastrointestinal hemorrhage

                          Increased release Acidosis

                          Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                          Renal insufficiencyfailure

                          Clinical manifestation of hyperkalemia

                          System hyperkalemia

                          Gastrointestinal Nauseavomiting colic diarrhea

                          Neuromuscular weakness paralysis respiratory failure

                          Cardiovascular Arrhythmia arrest

                          ECG changes Peaked T waves (early change)

                          Flattened P wave

                          Prolonged PR interval (first-degree block)

                          Widened QRS complex

                          Sine wave formation

                          Ventricular fibrillation

                          Treatment

                          Treatment of symptomatic hyperkalemia

                          Potassium removal Kayexalate

                          Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                          Rectal administration is 50 g in 200 mL 20 sorbitol

                          Dialysis

                          Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                          Bicarbonate 1 vial intravenous

                          Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                          HypokalemiaEtiology

                          inadequate intake

                          Dietary potassium-free intravenous fluids potassium-deficient

                          total parenteral nutrition

                          Excessive potassium excretion

                          Hyperaldosteronism

                          Medications

                          Gastrointestinal losses

                          Direct loss of potassium from gastrointestinal fluid (diarrhea)

                          Renal loss of potassium (gastric fluid either as vomiting or high

                          nasogastric output)

                          Intracellular-shift (metabolic alkalosis or insulin therapy)

                          Potassium changes associated with alkalosis

                          Potassium decrease by 03 meqL for every 01

                          increase in PH above normal

                          Magnesium Depletion

                          (drug induced amphotericin amioglycosides cisplatin)

                          Renal potassium wastage

                          Hypokalemia

                          Magnesium Depletion

                          (drug induced amphotericin amioglycosides cisplatin)

                          Renal potassium wastage

                          Hypokalemia

                          Clinical Manifestation of Abnormalities in potassium

                          System hypokalemia

                          Gastrointestinal Ileus constipation

                          Neuromuscular Decreased reflexes fatigue weakness

                          paralysis

                          Cardiovascular Arrest

                          ECG changes U-waves

                          T-wave flattening

                          ST-segment changes

                          Arrhythmias

                          Treatment

                          Potassium

                          Serum potassium level lt40 mEqL

                          Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                          times 1 doses

                          Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                          Symptomatic KC1 20 mEq IV q1h times 4 doses

                          Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                          asymptomatic replace as per above protocol

                          Electrolyte Replacement Therapy Protocol

                          bull Oral repletion for mild and asymptomatic hypokalemia

                          bull IV repletion for severe and symptomatic hypokalemia

                          Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                          ( دندانها( ndash استخوانbull كلسيم نقش

                          عصبي 1 ايمپالسهاي )NMJ(انتقال

                          صاف 2 عضالت انقباض

                          هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                          انعقاد 4

                          یونیزه Calt45 meql هيپوكلسمي

                          عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                          ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                          میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                          ( شود می پیوند شده

                          هیپوکلسمی عالئم

                          رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                          سایرعالئم

                          قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                          درمان

                          ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                          Cagt55meql هيپركلسمي

                          هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                          عالئم

                          bullGI

                          bullCardiovascular bullRenal (polyuria)

                          bullCNS

                          قلبی عالئم

                          bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                          QRS شدن )Q-Tوكوتاه

                          درمان

                          ایزوتونیک 1 نمکی محلول انفوزیون

                          الزیکس2

                          تونین 3 کلسی

                          کورتون4

                          دیالیز5

                          Magnesium Abnormalities

                          Normal dietary intake 20meq (240mg)

                          Excretion in both the feces and urine

                          Normal serum level 19-25 mgdL

                          منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                          تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                          bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                          Hypermagnesemia

                          Etiology

                          1 Impaired renal function

                          2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                          Clinical manifestation hypermanesemia

                          System hypermanesemia

                          Gastrointestinal Nauseavomiting

                          Neuromuscular weakness lethargy Decreased

                          reflexes

                          Cardiovascular Hypotension arrest

                          ECG changes Increased PR interval

                          Widened QRS complex

                          Elevated T waves

                          Treatment

                          1 Withhold exogenous sources of magnesium

                          2 Correct volume deficit

                          3 Correct acidosis if present

                          4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                          5 Dialysis (if elevated levels or symptoms persist)

                          عالئم

                          bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                          meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                          meqL

                          Hypomagnesemia

                          Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                          homeostasis

                          Etiology

                          1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                          inadequate supplementation of magnesium)

                          2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                          3 GI losses (diarrhea)

                          4 Malabsorption

                          5 Acute pancreatitis

                          6 Diabetic ketoacidosis

                          7 Primary aldosteronism

                          Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                          1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                          2 Delirium and seizures in severe deficiency

                          3 ECG changes Prolonged QT and PR interval

                          ST-segment depression

                          Flattening or inversion of P waves

                          Torsades de pointes

                          Arrhythmia

                          Treatment

                          1 For asymptomatic and mild hypomagnesemia administer oral mg

                          2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                          Message for Today

                          ICF

                          Interstitial

                          Pla

                          sma

                          5 Dex

                          bull Do not reccussitate sick patients with any Dextrose solution

                          • Fluid and Electrolyte Management of the Surgical Patient
                          • Slide 2
                          • Slide 3
                          • Slide 4
                          • Total Body Water
                          • Body Fluid Compartments
                          • Total body water (TBW)
                          • Body compartment fluid
                          • Example men with 70kg
                          • Fluid compartments
                          • Slide 11
                          • Slide 12
                          • Slide 13
                          • Slide 14
                          • Slide 15
                          • Colloid osmotic pressure
                          • Slide 17
                          • Slide 18
                          • Slide 19
                          • Cell Membrane
                          • Slide 21
                          • Slide 22
                          • Slide 23
                          • Slide 24
                          • Slide 25
                          • Composition of Fluid Compartments
                          • Composition of Body Fluids
                          • عوامل موثر روی تغییرات آب والکترولیت
                          • Reasons for fluid therapy
                          • ارزیابی حجم مایع داخل عروقی
                          • محلولهای وریدی
                          • Fluids
                          • Slide 33
                          • Slide 34
                          • Slide 35
                          • Crystalloids
                          • Colloid Solutions
                          • رینگر لاکتات
                          • 09Nacl
                          • Postoperative (maintenance)
                          • Slide 41
                          • Preexisting fluid deficits
                          • Maintenance requirements
                          • Surgical fluid losses
                          • Third space loss
                          • Crystalloid solution
                          • Colloids
                          • Complications
                          • The Influence of Colloid amp Crystalloid on Blood Volume
                          • Colloid versus crystalloid solutions
                          • Transfusion consideration
                          • اختلال در حجم مایعات بدن
                          • Fluid volume deficit (FVD)
                          • DEHYDRATION
                          • علل کاهش حجم خارج سلولی
                          • Signs of Hypovolemia
                          • Clinical Diagnosis of Hypovolemia
                          • Signs of Hypervolemia
                          • Management of Hypervolemia
                          • Fluid Management
                          • Electrolyte physiology
                          • Sodium physiology
                          • Osmotic Pressure
                          • Concentration
                          • Hypernatremia
                          • - Hypernatremia
                          • Slide 67
                          • Slide 68
                          • Clinical Manifestations of Abnormalities in Serum Sodium
                          • Treatment
                          • Water deficit (L)= times TBW
                          • The rate of fluid administration
                          • Hyponatremia Nalt135mEqL
                          • Slide 74
                          • Sodium depletion
                          • Sodium dilution
                          • Sign and symptoms
                          • Slide 78
                          • Treatment
                          • Slide 80
                          • Slide 81
                          • Dose
                          • Potassium abnormalities
                          • Hyperkalemia
                          • Clinical manifestation of hyperkalemia
                          • Slide 86
                          • Slide 87
                          • Hypokalemia
                          • Potassium changes associated with alkalosis
                          • Slide 90
                          • Clinical Manifestation of Abnormalities in potassium
                          • Slide 92
                          • Calcium
                          • هيپوكلسمي یونیزه Calt45 meql
                          • علائم هیپوکلسمی
                          • Slide 96
                          • Slide 97
                          • Slide 98
                          • Slide 99
                          • سایرعلائم
                          • درمان
                          • هيپركلسمي Cagt55meql
                          • علائم
                          • علائم قلبی
                          • Slide 105
                          • Magnesium Abnormalities
                          • منیزیوم
                          • Hypermagnesemia
                          • Clinical manifestation hypermanesemia
                          • Slide 110
                          • Slide 111
                          • Hypomagnesemia
                          • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                          • Slide 114
                          • Message for Today
                          • Slide 116

                            Fluid compartments

                            ICF

                            ECF

                            Interstitial

                            Pla

                            sma

                            Capillary Membrane

                            Fluid compartments

                            ICF

                            ECF

                            Interstitial

                            Pla

                            sma

                            Capillary Membrane Cell Membrane

                            Colloid osmotic pressure

                            ECF

                            Interstitial

                            Pla

                            sma

                            Capillary Membrane

                            Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                            Colloid osmotic pressure

                            ECF

                            Interstitial

                            Pla

                            sma

                            Capillary Membrane

                            Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                            Colloid osmotic pressure

                            ECF

                            Interstitial

                            Pla

                            sma

                            Capillary Membrane

                            Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                            The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                            H2O

                            H2O

                            Colloid osmotic pressure

                            ECF

                            Interstitial

                            Pla

                            sma

                            Capillary Membrane

                            Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                            The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                            This is balanced out by the hydrostatic pressure difference

                            H2O

                            H2O12080

                            H2O

                            H2O

                            Cell Membrane

                            ICF

                            Cell Membrane

                            Interstitial

                            H2O

                            H2O

                            Cell membrane is freely permeable to H20 but

                            Cell Membrane

                            ICF

                            Cell Membrane

                            Na+

                            K+

                            Interstitial

                            H2O

                            H2O

                            Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                            Cell Membrane

                            ICF

                            Cell Membrane

                            Na-

                            K+

                            Interstitial

                            H2O

                            H2O

                            Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                            [K+] =4

                            Cell Membrane

                            ICF

                            Cell Membrane

                            Na-

                            K+

                            Interstitial

                            H2O

                            H2O

                            Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                            [K+] =4 [K+] =150

                            Cell Membrane

                            ICF

                            Cell Membrane

                            Na-

                            K+

                            Interstitial

                            H2O

                            H2O

                            Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                            [K+] =4 [K+] =150

                            Na+= 144

                            Cell Membrane

                            ICF

                            Cell Membrane

                            Na-

                            K+

                            Interstitial

                            H2O

                            H2O

                            Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                            [K+] =4 [K+] =150

                            Na+= 144Na+= 10

                            Composition of Fluid Compartments

                            CATIONS ANIONS

                            Na+ 142 Cl - 103

                            HC03- 27

                            504mdash

                            3 PO4

                            ---

                            K+ 4 organicCa++ 5 Acid 5

                            Mg++ 3 Protein 16

                            CATIONS ANIONS

                            Na+ 144 Cl - 114

                            HC03- 30

                            504mdash

                            K+ 4 3 PO4

                            ---

                            organic

                            Ca++ 3 Acid 5

                            Mg++ 2 Protein 1

                            CATIONS ANIONS

                            K+ 150 HPO4

                            150 504

                            mdash

                            HCO3- 10

                            Mg++ 40 Protein 40

                            Na+ 10

                            154 mEqL 153 mEqL 153 mEqL154 mEqL

                            PLASMA INTERSTITAL FLID

                            200 mEqL 200 mEqL

                            INTRACELLULAR FLID

                            Composition of Body FluidsComposition of Body Fluids

                            Ca 2+

                            Mg 2+

                            K+

                            Na+

                            Cl-

                            PO43-

                            Organic anion

                            HCO3-

                            Protein

                            0

                            50

                            50

                            100

                            150

                            100

                            150

                            Cations Anions

                            EC

                            FICF

                            Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                            والکترولیت آب تغییرات روی موثر عوامل

                            1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                            عمل 2 از قبل والکترولیت آب وضعیت

                            اندوکرینوپاتی )3 همراه )بیماریهای

                            4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                            Reasons for fluid therapyReasons for fluid therapy

                            Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                            bull Correct hypovolaemiaCorrect hypovolaemia

                            bull Maintain cardiac outputMaintain cardiac output

                            bull Optimise gas exchangeOptimise gas exchange

                            bull Replace electrolytes amp waterReplace electrolytes amp water

                            bull Maintain urine outputMaintain urine output

                            Colloids + RBCs

                            Crystalloids

                            Identify what is the goal

                            Choose fluid which best achieves the goal

                            عروقی داخل مایع حجم ارزیابی

                            بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                            وریدی محلولهای

                            Fluids bull Crystalloids

                            bull Colloids

                            bull blood

                            Which of the following solutions is isotonic

                            A D5W

                            B 045 saline

                            C 09 saline

                            D D5 in 09 saline

                            SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                            ECFECF 142 4 5 103 27 280-310

                            Lactated Lactated RingerrsquosRingerrsquos

                            130 4 3 109 28 273

                            09 NaCl09 NaCl 154 154 308

                            045 045 NaClNaCl

                            77 77 154

                            D5WD5W

                            D5045 D5045 NaClNaCl

                            77 77 50 406

                            3 NaCl3 NaCl 513 513 1026

                            6 6 HetastarchHetastarch

                            500 154 154 310

                            5 5 AlbuminAlbumin

                            250500130-160

                            lt25130-160

                            330

                            25 25 AlbuminAlbumin

                            2050100130-160

                            lt25130-160

                            330

                            Common parenteral fluid therapyCommon parenteral fluid therapy

                            CrystalloidsCrystalloids

                            bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                            Colloid SolutionsColloid Solutions

                            bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                            - Haes-steril 10

                            الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                            کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                            ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                            osm=273

                            09Nacl

                            bull Na=154

                            bull CL= 154

                            کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                            PH=56است

                            Postoperative (maintenance)

                            045Nacl +5 dextrose +KCL

                            Perioperative management of fluid balance include

                            1 Preoperative evaluation

                            2 Intraoperative maintenance

                            3 Replacement of fluid losses

                            Preexisting fluid deficits

                            bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                            bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                            Maintenance requirements

                            bull Up to 10 kg = 4cckghr

                            bull 11-20kg = add 2cckghr

                            bull 21kg and above = add 1cckghr

                            bull Insensible losses = 2cckghr

                            Surgical fluid losses

                            Blood loss (measurement)

                            1 Suction container

                            2 Surgical sponge

                            3 Hct and tachycardia not specific

                            4 ABG and UO if hypoperfusion occur

                            5 Blood loss=31 with crystalloid

                            Other losses (third space loss)

                            Third space loss

                            1 Minimal (herniorrapy) =2-4cckghr

                            2 Moderate (cholecystectomy)=4-6cckghr

                            3 Severe (bowel resection) = 6-8cckghr

                            Crystalloid solution

                            1 The main solutions is either glucose or saline

                            2 Hypotonic or isotonic or hypertonic

                            3 Safe nontoxic reaction free inexpensive

                            4 Complication is edema if large volumes are needed

                            5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                            Colloids

                            1 Albumin

                            2 Hydroxyethyl starch

                            3 Dextran

                            Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                            factor )These colloid is best avoided in patients with

                            coagulopaty

                            The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                            1000cc

                            500cc

                            500cc

                            500cc

                            200

                            600

                            1000

                            Lactated Ringers

                            5 Albumin

                            6 Hetastarch

                            Whole blood

                            Blood volumeInfusion volume

                            Colloid versus crystalloid solutions

                            Transfusion consideration

                            bull HB lt7 mg dl increase CO

                            bull Ideal Hb is 7-8 mgdl

                            bull In IHD patients or pulmonary disease gt 10 mgdl

                            بدن مایعات حجم در اختالل

                            1 Fluid volume deficit

                            2 Fluid volume excess

                            Fluid volume deficit(FVD)

                            ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                            کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                            ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                            باشد آن با همراه دیگری اختالل مگر

                            DEHYDRATION

                            سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                            سلولی خارج حجم کاهش علل

                            1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                            2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                            کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                            Signs of HypovolemiaSigns of Hypovolemia

                            bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                            Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                            bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                            Signs of HypervolemiaSigns of Hypervolemia

                            bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                            Especially when hypo-albuminemia

                            Management of Management of HypervolemiaHypervolemia

                            bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                            Fluid ManagementFluid Management

                            bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                            Electrolyte physiology

                            Sodium physiology

                            Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                            Normal amount 135-145 meql

                            Osmotic Pressure

                            Calculated serum osmolality =

                            2 sodium+ glucose18 + BUN 28

                            Osmolality = 290 mosm

                            Concentration

                            1Serum sodium concentration2Serum osmolarity

                            bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                            drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                            DW5)

                            Hypernatremia

                            Serum Nagt145mEqL

                            - Hypernatremia

                            Loss of Free Water

                            Gain of sodium in excess of water

                            Hypernatremia

                            -Hypernatremia Hypo volemic

                            Hyper volemic

                            Normo volemic

                            Hypernatremia

                            Volume Status

                            Normal

                            Nonrenal water loss

                            Skin

                            Gastrointestinal

                            Renal water loss

                            Renal disease

                            Diuretics

                            Diabetes insipidus

                            High

                            Iatrogenic sodium administration

                            Mineralocorticoid excess

                            Aldosteronism

                            Cushingrsquos disease

                            Congenital adrenal

                            hyperplasia

                            Low

                            Nonrenal water loss

                            Skin

                            Gastrointestinal losses

                            Renal water losses

                            Renal (tubular) Diuretics

                            Osmotic diuretics

                            Diabetes insipidus

                            Adrenal failure

                            Asymptomatic

                            Hypernatremia Symptomatic (Nagt160 meqL)

                            Clinical Manifestations of Abnormalities in Serum Sodium

                            Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                            Body system hypernatremia

                            Treatment

                            Normal saline in hypovolemic patients

                            Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                            saline or entral water)

                            Water deficit (L)= times TBW

                            The formula used to estimate the amount of water required to correct hypernatremia

                            Estimate TBW as 55 of lean body mass in men and 45 in women

                            Serum sodium-140

                            140

                            The rate of fluid administration

                            1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                            2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                            Hyponatremia Nalt135mEqL

                            Causes

                            1 Sodium depletion

                            2 Sodium dilution

                            bull Incidence = 45

                            bull After surgery=1

                            bull Mortality = 2 times normal

                            Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                            volume deficit

                            Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                            Sign and symptoms

                            bull CNS symptom when Nalt123 meql

                            bull Cardiac symptom when Nalt100 meql

                            For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                            Body System Hyponatremia

                            central nervous system Headache confusion hyper-or hypoactive deep tendon

                            reflexes seizures coma increased intracranial pressure

                            Musculoskeletal Weakness fatigue muscle crampstwitching

                            Gastrointestinal Anorexia nausea vomiting watery diarrhea

                            Cardiovascular Hypertension and bradycardia if significant increases in

                            intracranial pressure

                            Tissue Lacrimation salivation

                            Renal Oliguria

                            Clinical Manifestations of Abnormalities in Serum Sodium

                            Treatment

                            1=Depend on ECF

                            2=CNS sign

                            Treatment

                            1 Asymptomatic increase the sodium level by no more than

                            05-1 meqLh to a maximum increase of 12 meqL per day

                            2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                            more than 1meqL per hour until the serum Na level reaches 130

                            meqL or neurologic symptoms are improved

                            Rapid correction of hyponatremia

                            Pontine myelinolysis

                            Seizures weaknessparesis akinetic

                            movements unresponsiveness

                            Permanent brain damage

                            Death

                            Dose

                            Na deficit meq =(140- Na meql) TBW

                            باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                            شود اصالح آهسته سپس

                            Potassium abnormalities

                            bull The average dietary intake of potassium 50-100meqd

                            bull The average renal excretion of potassium 10-700 meqd

                            - 2 of the total body potassium in ECF (45meqL)

                            - Factors that influence serum potassium

                            1 Surgical stress

                            2 Injury

                            3 Acidosis

                            4 Tissue catabolism

                            Hyperkalemia

                            The normal range of serum potassium 35-5 meqL

                            Etiology of Hyperkalemia

                            Increased intake Potassium supplementation

                            Blood transfusions

                            Endogenous loaddestruction

                            hemolysis rhabdomyolysis

                            cruch injury gastrointestinal hemorrhage

                            Increased release Acidosis

                            Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                            Renal insufficiencyfailure

                            Clinical manifestation of hyperkalemia

                            System hyperkalemia

                            Gastrointestinal Nauseavomiting colic diarrhea

                            Neuromuscular weakness paralysis respiratory failure

                            Cardiovascular Arrhythmia arrest

                            ECG changes Peaked T waves (early change)

                            Flattened P wave

                            Prolonged PR interval (first-degree block)

                            Widened QRS complex

                            Sine wave formation

                            Ventricular fibrillation

                            Treatment

                            Treatment of symptomatic hyperkalemia

                            Potassium removal Kayexalate

                            Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                            Rectal administration is 50 g in 200 mL 20 sorbitol

                            Dialysis

                            Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                            Bicarbonate 1 vial intravenous

                            Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                            HypokalemiaEtiology

                            inadequate intake

                            Dietary potassium-free intravenous fluids potassium-deficient

                            total parenteral nutrition

                            Excessive potassium excretion

                            Hyperaldosteronism

                            Medications

                            Gastrointestinal losses

                            Direct loss of potassium from gastrointestinal fluid (diarrhea)

                            Renal loss of potassium (gastric fluid either as vomiting or high

                            nasogastric output)

                            Intracellular-shift (metabolic alkalosis or insulin therapy)

                            Potassium changes associated with alkalosis

                            Potassium decrease by 03 meqL for every 01

                            increase in PH above normal

                            Magnesium Depletion

                            (drug induced amphotericin amioglycosides cisplatin)

                            Renal potassium wastage

                            Hypokalemia

                            Magnesium Depletion

                            (drug induced amphotericin amioglycosides cisplatin)

                            Renal potassium wastage

                            Hypokalemia

                            Clinical Manifestation of Abnormalities in potassium

                            System hypokalemia

                            Gastrointestinal Ileus constipation

                            Neuromuscular Decreased reflexes fatigue weakness

                            paralysis

                            Cardiovascular Arrest

                            ECG changes U-waves

                            T-wave flattening

                            ST-segment changes

                            Arrhythmias

                            Treatment

                            Potassium

                            Serum potassium level lt40 mEqL

                            Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                            times 1 doses

                            Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                            Symptomatic KC1 20 mEq IV q1h times 4 doses

                            Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                            asymptomatic replace as per above protocol

                            Electrolyte Replacement Therapy Protocol

                            bull Oral repletion for mild and asymptomatic hypokalemia

                            bull IV repletion for severe and symptomatic hypokalemia

                            Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                            ( دندانها( ndash استخوانbull كلسيم نقش

                            عصبي 1 ايمپالسهاي )NMJ(انتقال

                            صاف 2 عضالت انقباض

                            هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                            انعقاد 4

                            یونیزه Calt45 meql هيپوكلسمي

                            عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                            ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                            میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                            ( شود می پیوند شده

                            هیپوکلسمی عالئم

                            رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                            سایرعالئم

                            قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                            درمان

                            ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                            Cagt55meql هيپركلسمي

                            هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                            عالئم

                            bullGI

                            bullCardiovascular bullRenal (polyuria)

                            bullCNS

                            قلبی عالئم

                            bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                            QRS شدن )Q-Tوكوتاه

                            درمان

                            ایزوتونیک 1 نمکی محلول انفوزیون

                            الزیکس2

                            تونین 3 کلسی

                            کورتون4

                            دیالیز5

                            Magnesium Abnormalities

                            Normal dietary intake 20meq (240mg)

                            Excretion in both the feces and urine

                            Normal serum level 19-25 mgdL

                            منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                            تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                            bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                            Hypermagnesemia

                            Etiology

                            1 Impaired renal function

                            2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                            Clinical manifestation hypermanesemia

                            System hypermanesemia

                            Gastrointestinal Nauseavomiting

                            Neuromuscular weakness lethargy Decreased

                            reflexes

                            Cardiovascular Hypotension arrest

                            ECG changes Increased PR interval

                            Widened QRS complex

                            Elevated T waves

                            Treatment

                            1 Withhold exogenous sources of magnesium

                            2 Correct volume deficit

                            3 Correct acidosis if present

                            4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                            5 Dialysis (if elevated levels or symptoms persist)

                            عالئم

                            bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                            meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                            meqL

                            Hypomagnesemia

                            Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                            homeostasis

                            Etiology

                            1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                            inadequate supplementation of magnesium)

                            2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                            3 GI losses (diarrhea)

                            4 Malabsorption

                            5 Acute pancreatitis

                            6 Diabetic ketoacidosis

                            7 Primary aldosteronism

                            Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                            1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                            2 Delirium and seizures in severe deficiency

                            3 ECG changes Prolonged QT and PR interval

                            ST-segment depression

                            Flattening or inversion of P waves

                            Torsades de pointes

                            Arrhythmia

                            Treatment

                            1 For asymptomatic and mild hypomagnesemia administer oral mg

                            2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                            Message for Today

                            ICF

                            Interstitial

                            Pla

                            sma

                            5 Dex

                            bull Do not reccussitate sick patients with any Dextrose solution

                            • Fluid and Electrolyte Management of the Surgical Patient
                            • Slide 2
                            • Slide 3
                            • Slide 4
                            • Total Body Water
                            • Body Fluid Compartments
                            • Total body water (TBW)
                            • Body compartment fluid
                            • Example men with 70kg
                            • Fluid compartments
                            • Slide 11
                            • Slide 12
                            • Slide 13
                            • Slide 14
                            • Slide 15
                            • Colloid osmotic pressure
                            • Slide 17
                            • Slide 18
                            • Slide 19
                            • Cell Membrane
                            • Slide 21
                            • Slide 22
                            • Slide 23
                            • Slide 24
                            • Slide 25
                            • Composition of Fluid Compartments
                            • Composition of Body Fluids
                            • عوامل موثر روی تغییرات آب والکترولیت
                            • Reasons for fluid therapy
                            • ارزیابی حجم مایع داخل عروقی
                            • محلولهای وریدی
                            • Fluids
                            • Slide 33
                            • Slide 34
                            • Slide 35
                            • Crystalloids
                            • Colloid Solutions
                            • رینگر لاکتات
                            • 09Nacl
                            • Postoperative (maintenance)
                            • Slide 41
                            • Preexisting fluid deficits
                            • Maintenance requirements
                            • Surgical fluid losses
                            • Third space loss
                            • Crystalloid solution
                            • Colloids
                            • Complications
                            • The Influence of Colloid amp Crystalloid on Blood Volume
                            • Colloid versus crystalloid solutions
                            • Transfusion consideration
                            • اختلال در حجم مایعات بدن
                            • Fluid volume deficit (FVD)
                            • DEHYDRATION
                            • علل کاهش حجم خارج سلولی
                            • Signs of Hypovolemia
                            • Clinical Diagnosis of Hypovolemia
                            • Signs of Hypervolemia
                            • Management of Hypervolemia
                            • Fluid Management
                            • Electrolyte physiology
                            • Sodium physiology
                            • Osmotic Pressure
                            • Concentration
                            • Hypernatremia
                            • - Hypernatremia
                            • Slide 67
                            • Slide 68
                            • Clinical Manifestations of Abnormalities in Serum Sodium
                            • Treatment
                            • Water deficit (L)= times TBW
                            • The rate of fluid administration
                            • Hyponatremia Nalt135mEqL
                            • Slide 74
                            • Sodium depletion
                            • Sodium dilution
                            • Sign and symptoms
                            • Slide 78
                            • Treatment
                            • Slide 80
                            • Slide 81
                            • Dose
                            • Potassium abnormalities
                            • Hyperkalemia
                            • Clinical manifestation of hyperkalemia
                            • Slide 86
                            • Slide 87
                            • Hypokalemia
                            • Potassium changes associated with alkalosis
                            • Slide 90
                            • Clinical Manifestation of Abnormalities in potassium
                            • Slide 92
                            • Calcium
                            • هيپوكلسمي یونیزه Calt45 meql
                            • علائم هیپوکلسمی
                            • Slide 96
                            • Slide 97
                            • Slide 98
                            • Slide 99
                            • سایرعلائم
                            • درمان
                            • هيپركلسمي Cagt55meql
                            • علائم
                            • علائم قلبی
                            • Slide 105
                            • Magnesium Abnormalities
                            • منیزیوم
                            • Hypermagnesemia
                            • Clinical manifestation hypermanesemia
                            • Slide 110
                            • Slide 111
                            • Hypomagnesemia
                            • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                            • Slide 114
                            • Message for Today
                            • Slide 116

                              Fluid compartments

                              ICF

                              ECF

                              Interstitial

                              Pla

                              sma

                              Capillary Membrane Cell Membrane

                              Colloid osmotic pressure

                              ECF

                              Interstitial

                              Pla

                              sma

                              Capillary Membrane

                              Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                              Colloid osmotic pressure

                              ECF

                              Interstitial

                              Pla

                              sma

                              Capillary Membrane

                              Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                              Colloid osmotic pressure

                              ECF

                              Interstitial

                              Pla

                              sma

                              Capillary Membrane

                              Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                              The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                              H2O

                              H2O

                              Colloid osmotic pressure

                              ECF

                              Interstitial

                              Pla

                              sma

                              Capillary Membrane

                              Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                              The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                              This is balanced out by the hydrostatic pressure difference

                              H2O

                              H2O12080

                              H2O

                              H2O

                              Cell Membrane

                              ICF

                              Cell Membrane

                              Interstitial

                              H2O

                              H2O

                              Cell membrane is freely permeable to H20 but

                              Cell Membrane

                              ICF

                              Cell Membrane

                              Na+

                              K+

                              Interstitial

                              H2O

                              H2O

                              Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                              Cell Membrane

                              ICF

                              Cell Membrane

                              Na-

                              K+

                              Interstitial

                              H2O

                              H2O

                              Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                              [K+] =4

                              Cell Membrane

                              ICF

                              Cell Membrane

                              Na-

                              K+

                              Interstitial

                              H2O

                              H2O

                              Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                              [K+] =4 [K+] =150

                              Cell Membrane

                              ICF

                              Cell Membrane

                              Na-

                              K+

                              Interstitial

                              H2O

                              H2O

                              Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                              [K+] =4 [K+] =150

                              Na+= 144

                              Cell Membrane

                              ICF

                              Cell Membrane

                              Na-

                              K+

                              Interstitial

                              H2O

                              H2O

                              Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                              [K+] =4 [K+] =150

                              Na+= 144Na+= 10

                              Composition of Fluid Compartments

                              CATIONS ANIONS

                              Na+ 142 Cl - 103

                              HC03- 27

                              504mdash

                              3 PO4

                              ---

                              K+ 4 organicCa++ 5 Acid 5

                              Mg++ 3 Protein 16

                              CATIONS ANIONS

                              Na+ 144 Cl - 114

                              HC03- 30

                              504mdash

                              K+ 4 3 PO4

                              ---

                              organic

                              Ca++ 3 Acid 5

                              Mg++ 2 Protein 1

                              CATIONS ANIONS

                              K+ 150 HPO4

                              150 504

                              mdash

                              HCO3- 10

                              Mg++ 40 Protein 40

                              Na+ 10

                              154 mEqL 153 mEqL 153 mEqL154 mEqL

                              PLASMA INTERSTITAL FLID

                              200 mEqL 200 mEqL

                              INTRACELLULAR FLID

                              Composition of Body FluidsComposition of Body Fluids

                              Ca 2+

                              Mg 2+

                              K+

                              Na+

                              Cl-

                              PO43-

                              Organic anion

                              HCO3-

                              Protein

                              0

                              50

                              50

                              100

                              150

                              100

                              150

                              Cations Anions

                              EC

                              FICF

                              Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                              والکترولیت آب تغییرات روی موثر عوامل

                              1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                              عمل 2 از قبل والکترولیت آب وضعیت

                              اندوکرینوپاتی )3 همراه )بیماریهای

                              4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                              Reasons for fluid therapyReasons for fluid therapy

                              Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                              bull Correct hypovolaemiaCorrect hypovolaemia

                              bull Maintain cardiac outputMaintain cardiac output

                              bull Optimise gas exchangeOptimise gas exchange

                              bull Replace electrolytes amp waterReplace electrolytes amp water

                              bull Maintain urine outputMaintain urine output

                              Colloids + RBCs

                              Crystalloids

                              Identify what is the goal

                              Choose fluid which best achieves the goal

                              عروقی داخل مایع حجم ارزیابی

                              بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                              وریدی محلولهای

                              Fluids bull Crystalloids

                              bull Colloids

                              bull blood

                              Which of the following solutions is isotonic

                              A D5W

                              B 045 saline

                              C 09 saline

                              D D5 in 09 saline

                              SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                              ECFECF 142 4 5 103 27 280-310

                              Lactated Lactated RingerrsquosRingerrsquos

                              130 4 3 109 28 273

                              09 NaCl09 NaCl 154 154 308

                              045 045 NaClNaCl

                              77 77 154

                              D5WD5W

                              D5045 D5045 NaClNaCl

                              77 77 50 406

                              3 NaCl3 NaCl 513 513 1026

                              6 6 HetastarchHetastarch

                              500 154 154 310

                              5 5 AlbuminAlbumin

                              250500130-160

                              lt25130-160

                              330

                              25 25 AlbuminAlbumin

                              2050100130-160

                              lt25130-160

                              330

                              Common parenteral fluid therapyCommon parenteral fluid therapy

                              CrystalloidsCrystalloids

                              bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                              Colloid SolutionsColloid Solutions

                              bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                              - Haes-steril 10

                              الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                              کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                              ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                              osm=273

                              09Nacl

                              bull Na=154

                              bull CL= 154

                              کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                              PH=56است

                              Postoperative (maintenance)

                              045Nacl +5 dextrose +KCL

                              Perioperative management of fluid balance include

                              1 Preoperative evaluation

                              2 Intraoperative maintenance

                              3 Replacement of fluid losses

                              Preexisting fluid deficits

                              bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                              bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                              Maintenance requirements

                              bull Up to 10 kg = 4cckghr

                              bull 11-20kg = add 2cckghr

                              bull 21kg and above = add 1cckghr

                              bull Insensible losses = 2cckghr

                              Surgical fluid losses

                              Blood loss (measurement)

                              1 Suction container

                              2 Surgical sponge

                              3 Hct and tachycardia not specific

                              4 ABG and UO if hypoperfusion occur

                              5 Blood loss=31 with crystalloid

                              Other losses (third space loss)

                              Third space loss

                              1 Minimal (herniorrapy) =2-4cckghr

                              2 Moderate (cholecystectomy)=4-6cckghr

                              3 Severe (bowel resection) = 6-8cckghr

                              Crystalloid solution

                              1 The main solutions is either glucose or saline

                              2 Hypotonic or isotonic or hypertonic

                              3 Safe nontoxic reaction free inexpensive

                              4 Complication is edema if large volumes are needed

                              5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                              Colloids

                              1 Albumin

                              2 Hydroxyethyl starch

                              3 Dextran

                              Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                              factor )These colloid is best avoided in patients with

                              coagulopaty

                              The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                              1000cc

                              500cc

                              500cc

                              500cc

                              200

                              600

                              1000

                              Lactated Ringers

                              5 Albumin

                              6 Hetastarch

                              Whole blood

                              Blood volumeInfusion volume

                              Colloid versus crystalloid solutions

                              Transfusion consideration

                              bull HB lt7 mg dl increase CO

                              bull Ideal Hb is 7-8 mgdl

                              bull In IHD patients or pulmonary disease gt 10 mgdl

                              بدن مایعات حجم در اختالل

                              1 Fluid volume deficit

                              2 Fluid volume excess

                              Fluid volume deficit(FVD)

                              ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                              کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                              ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                              باشد آن با همراه دیگری اختالل مگر

                              DEHYDRATION

                              سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                              سلولی خارج حجم کاهش علل

                              1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                              2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                              کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                              Signs of HypovolemiaSigns of Hypovolemia

                              bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                              Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                              bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                              Signs of HypervolemiaSigns of Hypervolemia

                              bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                              Especially when hypo-albuminemia

                              Management of Management of HypervolemiaHypervolemia

                              bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                              Fluid ManagementFluid Management

                              bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                              Electrolyte physiology

                              Sodium physiology

                              Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                              Normal amount 135-145 meql

                              Osmotic Pressure

                              Calculated serum osmolality =

                              2 sodium+ glucose18 + BUN 28

                              Osmolality = 290 mosm

                              Concentration

                              1Serum sodium concentration2Serum osmolarity

                              bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                              drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                              DW5)

                              Hypernatremia

                              Serum Nagt145mEqL

                              - Hypernatremia

                              Loss of Free Water

                              Gain of sodium in excess of water

                              Hypernatremia

                              -Hypernatremia Hypo volemic

                              Hyper volemic

                              Normo volemic

                              Hypernatremia

                              Volume Status

                              Normal

                              Nonrenal water loss

                              Skin

                              Gastrointestinal

                              Renal water loss

                              Renal disease

                              Diuretics

                              Diabetes insipidus

                              High

                              Iatrogenic sodium administration

                              Mineralocorticoid excess

                              Aldosteronism

                              Cushingrsquos disease

                              Congenital adrenal

                              hyperplasia

                              Low

                              Nonrenal water loss

                              Skin

                              Gastrointestinal losses

                              Renal water losses

                              Renal (tubular) Diuretics

                              Osmotic diuretics

                              Diabetes insipidus

                              Adrenal failure

                              Asymptomatic

                              Hypernatremia Symptomatic (Nagt160 meqL)

                              Clinical Manifestations of Abnormalities in Serum Sodium

                              Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                              Body system hypernatremia

                              Treatment

                              Normal saline in hypovolemic patients

                              Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                              saline or entral water)

                              Water deficit (L)= times TBW

                              The formula used to estimate the amount of water required to correct hypernatremia

                              Estimate TBW as 55 of lean body mass in men and 45 in women

                              Serum sodium-140

                              140

                              The rate of fluid administration

                              1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                              2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                              Hyponatremia Nalt135mEqL

                              Causes

                              1 Sodium depletion

                              2 Sodium dilution

                              bull Incidence = 45

                              bull After surgery=1

                              bull Mortality = 2 times normal

                              Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                              volume deficit

                              Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                              Sign and symptoms

                              bull CNS symptom when Nalt123 meql

                              bull Cardiac symptom when Nalt100 meql

                              For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                              Body System Hyponatremia

                              central nervous system Headache confusion hyper-or hypoactive deep tendon

                              reflexes seizures coma increased intracranial pressure

                              Musculoskeletal Weakness fatigue muscle crampstwitching

                              Gastrointestinal Anorexia nausea vomiting watery diarrhea

                              Cardiovascular Hypertension and bradycardia if significant increases in

                              intracranial pressure

                              Tissue Lacrimation salivation

                              Renal Oliguria

                              Clinical Manifestations of Abnormalities in Serum Sodium

                              Treatment

                              1=Depend on ECF

                              2=CNS sign

                              Treatment

                              1 Asymptomatic increase the sodium level by no more than

                              05-1 meqLh to a maximum increase of 12 meqL per day

                              2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                              more than 1meqL per hour until the serum Na level reaches 130

                              meqL or neurologic symptoms are improved

                              Rapid correction of hyponatremia

                              Pontine myelinolysis

                              Seizures weaknessparesis akinetic

                              movements unresponsiveness

                              Permanent brain damage

                              Death

                              Dose

                              Na deficit meq =(140- Na meql) TBW

                              باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                              شود اصالح آهسته سپس

                              Potassium abnormalities

                              bull The average dietary intake of potassium 50-100meqd

                              bull The average renal excretion of potassium 10-700 meqd

                              - 2 of the total body potassium in ECF (45meqL)

                              - Factors that influence serum potassium

                              1 Surgical stress

                              2 Injury

                              3 Acidosis

                              4 Tissue catabolism

                              Hyperkalemia

                              The normal range of serum potassium 35-5 meqL

                              Etiology of Hyperkalemia

                              Increased intake Potassium supplementation

                              Blood transfusions

                              Endogenous loaddestruction

                              hemolysis rhabdomyolysis

                              cruch injury gastrointestinal hemorrhage

                              Increased release Acidosis

                              Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                              Renal insufficiencyfailure

                              Clinical manifestation of hyperkalemia

                              System hyperkalemia

                              Gastrointestinal Nauseavomiting colic diarrhea

                              Neuromuscular weakness paralysis respiratory failure

                              Cardiovascular Arrhythmia arrest

                              ECG changes Peaked T waves (early change)

                              Flattened P wave

                              Prolonged PR interval (first-degree block)

                              Widened QRS complex

                              Sine wave formation

                              Ventricular fibrillation

                              Treatment

                              Treatment of symptomatic hyperkalemia

                              Potassium removal Kayexalate

                              Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                              Rectal administration is 50 g in 200 mL 20 sorbitol

                              Dialysis

                              Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                              Bicarbonate 1 vial intravenous

                              Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                              HypokalemiaEtiology

                              inadequate intake

                              Dietary potassium-free intravenous fluids potassium-deficient

                              total parenteral nutrition

                              Excessive potassium excretion

                              Hyperaldosteronism

                              Medications

                              Gastrointestinal losses

                              Direct loss of potassium from gastrointestinal fluid (diarrhea)

                              Renal loss of potassium (gastric fluid either as vomiting or high

                              nasogastric output)

                              Intracellular-shift (metabolic alkalosis or insulin therapy)

                              Potassium changes associated with alkalosis

                              Potassium decrease by 03 meqL for every 01

                              increase in PH above normal

                              Magnesium Depletion

                              (drug induced amphotericin amioglycosides cisplatin)

                              Renal potassium wastage

                              Hypokalemia

                              Magnesium Depletion

                              (drug induced amphotericin amioglycosides cisplatin)

                              Renal potassium wastage

                              Hypokalemia

                              Clinical Manifestation of Abnormalities in potassium

                              System hypokalemia

                              Gastrointestinal Ileus constipation

                              Neuromuscular Decreased reflexes fatigue weakness

                              paralysis

                              Cardiovascular Arrest

                              ECG changes U-waves

                              T-wave flattening

                              ST-segment changes

                              Arrhythmias

                              Treatment

                              Potassium

                              Serum potassium level lt40 mEqL

                              Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                              times 1 doses

                              Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                              Symptomatic KC1 20 mEq IV q1h times 4 doses

                              Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                              asymptomatic replace as per above protocol

                              Electrolyte Replacement Therapy Protocol

                              bull Oral repletion for mild and asymptomatic hypokalemia

                              bull IV repletion for severe and symptomatic hypokalemia

                              Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                              ( دندانها( ndash استخوانbull كلسيم نقش

                              عصبي 1 ايمپالسهاي )NMJ(انتقال

                              صاف 2 عضالت انقباض

                              هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                              انعقاد 4

                              یونیزه Calt45 meql هيپوكلسمي

                              عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                              ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                              میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                              ( شود می پیوند شده

                              هیپوکلسمی عالئم

                              رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                              سایرعالئم

                              قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                              درمان

                              ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                              Cagt55meql هيپركلسمي

                              هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                              عالئم

                              bullGI

                              bullCardiovascular bullRenal (polyuria)

                              bullCNS

                              قلبی عالئم

                              bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                              QRS شدن )Q-Tوكوتاه

                              درمان

                              ایزوتونیک 1 نمکی محلول انفوزیون

                              الزیکس2

                              تونین 3 کلسی

                              کورتون4

                              دیالیز5

                              Magnesium Abnormalities

                              Normal dietary intake 20meq (240mg)

                              Excretion in both the feces and urine

                              Normal serum level 19-25 mgdL

                              منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                              تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                              bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                              Hypermagnesemia

                              Etiology

                              1 Impaired renal function

                              2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                              Clinical manifestation hypermanesemia

                              System hypermanesemia

                              Gastrointestinal Nauseavomiting

                              Neuromuscular weakness lethargy Decreased

                              reflexes

                              Cardiovascular Hypotension arrest

                              ECG changes Increased PR interval

                              Widened QRS complex

                              Elevated T waves

                              Treatment

                              1 Withhold exogenous sources of magnesium

                              2 Correct volume deficit

                              3 Correct acidosis if present

                              4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                              5 Dialysis (if elevated levels or symptoms persist)

                              عالئم

                              bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                              meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                              meqL

                              Hypomagnesemia

                              Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                              homeostasis

                              Etiology

                              1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                              inadequate supplementation of magnesium)

                              2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                              3 GI losses (diarrhea)

                              4 Malabsorption

                              5 Acute pancreatitis

                              6 Diabetic ketoacidosis

                              7 Primary aldosteronism

                              Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                              1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                              2 Delirium and seizures in severe deficiency

                              3 ECG changes Prolonged QT and PR interval

                              ST-segment depression

                              Flattening or inversion of P waves

                              Torsades de pointes

                              Arrhythmia

                              Treatment

                              1 For asymptomatic and mild hypomagnesemia administer oral mg

                              2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                              Message for Today

                              ICF

                              Interstitial

                              Pla

                              sma

                              5 Dex

                              bull Do not reccussitate sick patients with any Dextrose solution

                              • Fluid and Electrolyte Management of the Surgical Patient
                              • Slide 2
                              • Slide 3
                              • Slide 4
                              • Total Body Water
                              • Body Fluid Compartments
                              • Total body water (TBW)
                              • Body compartment fluid
                              • Example men with 70kg
                              • Fluid compartments
                              • Slide 11
                              • Slide 12
                              • Slide 13
                              • Slide 14
                              • Slide 15
                              • Colloid osmotic pressure
                              • Slide 17
                              • Slide 18
                              • Slide 19
                              • Cell Membrane
                              • Slide 21
                              • Slide 22
                              • Slide 23
                              • Slide 24
                              • Slide 25
                              • Composition of Fluid Compartments
                              • Composition of Body Fluids
                              • عوامل موثر روی تغییرات آب والکترولیت
                              • Reasons for fluid therapy
                              • ارزیابی حجم مایع داخل عروقی
                              • محلولهای وریدی
                              • Fluids
                              • Slide 33
                              • Slide 34
                              • Slide 35
                              • Crystalloids
                              • Colloid Solutions
                              • رینگر لاکتات
                              • 09Nacl
                              • Postoperative (maintenance)
                              • Slide 41
                              • Preexisting fluid deficits
                              • Maintenance requirements
                              • Surgical fluid losses
                              • Third space loss
                              • Crystalloid solution
                              • Colloids
                              • Complications
                              • The Influence of Colloid amp Crystalloid on Blood Volume
                              • Colloid versus crystalloid solutions
                              • Transfusion consideration
                              • اختلال در حجم مایعات بدن
                              • Fluid volume deficit (FVD)
                              • DEHYDRATION
                              • علل کاهش حجم خارج سلولی
                              • Signs of Hypovolemia
                              • Clinical Diagnosis of Hypovolemia
                              • Signs of Hypervolemia
                              • Management of Hypervolemia
                              • Fluid Management
                              • Electrolyte physiology
                              • Sodium physiology
                              • Osmotic Pressure
                              • Concentration
                              • Hypernatremia
                              • - Hypernatremia
                              • Slide 67
                              • Slide 68
                              • Clinical Manifestations of Abnormalities in Serum Sodium
                              • Treatment
                              • Water deficit (L)= times TBW
                              • The rate of fluid administration
                              • Hyponatremia Nalt135mEqL
                              • Slide 74
                              • Sodium depletion
                              • Sodium dilution
                              • Sign and symptoms
                              • Slide 78
                              • Treatment
                              • Slide 80
                              • Slide 81
                              • Dose
                              • Potassium abnormalities
                              • Hyperkalemia
                              • Clinical manifestation of hyperkalemia
                              • Slide 86
                              • Slide 87
                              • Hypokalemia
                              • Potassium changes associated with alkalosis
                              • Slide 90
                              • Clinical Manifestation of Abnormalities in potassium
                              • Slide 92
                              • Calcium
                              • هيپوكلسمي یونیزه Calt45 meql
                              • علائم هیپوکلسمی
                              • Slide 96
                              • Slide 97
                              • Slide 98
                              • Slide 99
                              • سایرعلائم
                              • درمان
                              • هيپركلسمي Cagt55meql
                              • علائم
                              • علائم قلبی
                              • Slide 105
                              • Magnesium Abnormalities
                              • منیزیوم
                              • Hypermagnesemia
                              • Clinical manifestation hypermanesemia
                              • Slide 110
                              • Slide 111
                              • Hypomagnesemia
                              • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                              • Slide 114
                              • Message for Today
                              • Slide 116

                                Colloid osmotic pressure

                                ECF

                                Interstitial

                                Pla

                                sma

                                Capillary Membrane

                                Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                                Colloid osmotic pressure

                                ECF

                                Interstitial

                                Pla

                                sma

                                Capillary Membrane

                                Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                                Colloid osmotic pressure

                                ECF

                                Interstitial

                                Pla

                                sma

                                Capillary Membrane

                                Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                                The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                                H2O

                                H2O

                                Colloid osmotic pressure

                                ECF

                                Interstitial

                                Pla

                                sma

                                Capillary Membrane

                                Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                                The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                                This is balanced out by the hydrostatic pressure difference

                                H2O

                                H2O12080

                                H2O

                                H2O

                                Cell Membrane

                                ICF

                                Cell Membrane

                                Interstitial

                                H2O

                                H2O

                                Cell membrane is freely permeable to H20 but

                                Cell Membrane

                                ICF

                                Cell Membrane

                                Na+

                                K+

                                Interstitial

                                H2O

                                H2O

                                Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                Cell Membrane

                                ICF

                                Cell Membrane

                                Na-

                                K+

                                Interstitial

                                H2O

                                H2O

                                Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                [K+] =4

                                Cell Membrane

                                ICF

                                Cell Membrane

                                Na-

                                K+

                                Interstitial

                                H2O

                                H2O

                                Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                [K+] =4 [K+] =150

                                Cell Membrane

                                ICF

                                Cell Membrane

                                Na-

                                K+

                                Interstitial

                                H2O

                                H2O

                                Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                [K+] =4 [K+] =150

                                Na+= 144

                                Cell Membrane

                                ICF

                                Cell Membrane

                                Na-

                                K+

                                Interstitial

                                H2O

                                H2O

                                Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                [K+] =4 [K+] =150

                                Na+= 144Na+= 10

                                Composition of Fluid Compartments

                                CATIONS ANIONS

                                Na+ 142 Cl - 103

                                HC03- 27

                                504mdash

                                3 PO4

                                ---

                                K+ 4 organicCa++ 5 Acid 5

                                Mg++ 3 Protein 16

                                CATIONS ANIONS

                                Na+ 144 Cl - 114

                                HC03- 30

                                504mdash

                                K+ 4 3 PO4

                                ---

                                organic

                                Ca++ 3 Acid 5

                                Mg++ 2 Protein 1

                                CATIONS ANIONS

                                K+ 150 HPO4

                                150 504

                                mdash

                                HCO3- 10

                                Mg++ 40 Protein 40

                                Na+ 10

                                154 mEqL 153 mEqL 153 mEqL154 mEqL

                                PLASMA INTERSTITAL FLID

                                200 mEqL 200 mEqL

                                INTRACELLULAR FLID

                                Composition of Body FluidsComposition of Body Fluids

                                Ca 2+

                                Mg 2+

                                K+

                                Na+

                                Cl-

                                PO43-

                                Organic anion

                                HCO3-

                                Protein

                                0

                                50

                                50

                                100

                                150

                                100

                                150

                                Cations Anions

                                EC

                                FICF

                                Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                                والکترولیت آب تغییرات روی موثر عوامل

                                1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                                عمل 2 از قبل والکترولیت آب وضعیت

                                اندوکرینوپاتی )3 همراه )بیماریهای

                                4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                                Reasons for fluid therapyReasons for fluid therapy

                                Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                                bull Correct hypovolaemiaCorrect hypovolaemia

                                bull Maintain cardiac outputMaintain cardiac output

                                bull Optimise gas exchangeOptimise gas exchange

                                bull Replace electrolytes amp waterReplace electrolytes amp water

                                bull Maintain urine outputMaintain urine output

                                Colloids + RBCs

                                Crystalloids

                                Identify what is the goal

                                Choose fluid which best achieves the goal

                                عروقی داخل مایع حجم ارزیابی

                                بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                                وریدی محلولهای

                                Fluids bull Crystalloids

                                bull Colloids

                                bull blood

                                Which of the following solutions is isotonic

                                A D5W

                                B 045 saline

                                C 09 saline

                                D D5 in 09 saline

                                SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                                ECFECF 142 4 5 103 27 280-310

                                Lactated Lactated RingerrsquosRingerrsquos

                                130 4 3 109 28 273

                                09 NaCl09 NaCl 154 154 308

                                045 045 NaClNaCl

                                77 77 154

                                D5WD5W

                                D5045 D5045 NaClNaCl

                                77 77 50 406

                                3 NaCl3 NaCl 513 513 1026

                                6 6 HetastarchHetastarch

                                500 154 154 310

                                5 5 AlbuminAlbumin

                                250500130-160

                                lt25130-160

                                330

                                25 25 AlbuminAlbumin

                                2050100130-160

                                lt25130-160

                                330

                                Common parenteral fluid therapyCommon parenteral fluid therapy

                                CrystalloidsCrystalloids

                                bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                Colloid SolutionsColloid Solutions

                                bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                - Haes-steril 10

                                الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                osm=273

                                09Nacl

                                bull Na=154

                                bull CL= 154

                                کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                PH=56است

                                Postoperative (maintenance)

                                045Nacl +5 dextrose +KCL

                                Perioperative management of fluid balance include

                                1 Preoperative evaluation

                                2 Intraoperative maintenance

                                3 Replacement of fluid losses

                                Preexisting fluid deficits

                                bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                Maintenance requirements

                                bull Up to 10 kg = 4cckghr

                                bull 11-20kg = add 2cckghr

                                bull 21kg and above = add 1cckghr

                                bull Insensible losses = 2cckghr

                                Surgical fluid losses

                                Blood loss (measurement)

                                1 Suction container

                                2 Surgical sponge

                                3 Hct and tachycardia not specific

                                4 ABG and UO if hypoperfusion occur

                                5 Blood loss=31 with crystalloid

                                Other losses (third space loss)

                                Third space loss

                                1 Minimal (herniorrapy) =2-4cckghr

                                2 Moderate (cholecystectomy)=4-6cckghr

                                3 Severe (bowel resection) = 6-8cckghr

                                Crystalloid solution

                                1 The main solutions is either glucose or saline

                                2 Hypotonic or isotonic or hypertonic

                                3 Safe nontoxic reaction free inexpensive

                                4 Complication is edema if large volumes are needed

                                5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                Colloids

                                1 Albumin

                                2 Hydroxyethyl starch

                                3 Dextran

                                Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                factor )These colloid is best avoided in patients with

                                coagulopaty

                                The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                1000cc

                                500cc

                                500cc

                                500cc

                                200

                                600

                                1000

                                Lactated Ringers

                                5 Albumin

                                6 Hetastarch

                                Whole blood

                                Blood volumeInfusion volume

                                Colloid versus crystalloid solutions

                                Transfusion consideration

                                bull HB lt7 mg dl increase CO

                                bull Ideal Hb is 7-8 mgdl

                                bull In IHD patients or pulmonary disease gt 10 mgdl

                                بدن مایعات حجم در اختالل

                                1 Fluid volume deficit

                                2 Fluid volume excess

                                Fluid volume deficit(FVD)

                                ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                باشد آن با همراه دیگری اختالل مگر

                                DEHYDRATION

                                سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                سلولی خارج حجم کاهش علل

                                1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                Signs of HypovolemiaSigns of Hypovolemia

                                bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                Signs of HypervolemiaSigns of Hypervolemia

                                bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                Especially when hypo-albuminemia

                                Management of Management of HypervolemiaHypervolemia

                                bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                Fluid ManagementFluid Management

                                bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                Electrolyte physiology

                                Sodium physiology

                                Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                Normal amount 135-145 meql

                                Osmotic Pressure

                                Calculated serum osmolality =

                                2 sodium+ glucose18 + BUN 28

                                Osmolality = 290 mosm

                                Concentration

                                1Serum sodium concentration2Serum osmolarity

                                bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                DW5)

                                Hypernatremia

                                Serum Nagt145mEqL

                                - Hypernatremia

                                Loss of Free Water

                                Gain of sodium in excess of water

                                Hypernatremia

                                -Hypernatremia Hypo volemic

                                Hyper volemic

                                Normo volemic

                                Hypernatremia

                                Volume Status

                                Normal

                                Nonrenal water loss

                                Skin

                                Gastrointestinal

                                Renal water loss

                                Renal disease

                                Diuretics

                                Diabetes insipidus

                                High

                                Iatrogenic sodium administration

                                Mineralocorticoid excess

                                Aldosteronism

                                Cushingrsquos disease

                                Congenital adrenal

                                hyperplasia

                                Low

                                Nonrenal water loss

                                Skin

                                Gastrointestinal losses

                                Renal water losses

                                Renal (tubular) Diuretics

                                Osmotic diuretics

                                Diabetes insipidus

                                Adrenal failure

                                Asymptomatic

                                Hypernatremia Symptomatic (Nagt160 meqL)

                                Clinical Manifestations of Abnormalities in Serum Sodium

                                Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                Body system hypernatremia

                                Treatment

                                Normal saline in hypovolemic patients

                                Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                saline or entral water)

                                Water deficit (L)= times TBW

                                The formula used to estimate the amount of water required to correct hypernatremia

                                Estimate TBW as 55 of lean body mass in men and 45 in women

                                Serum sodium-140

                                140

                                The rate of fluid administration

                                1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                Hyponatremia Nalt135mEqL

                                Causes

                                1 Sodium depletion

                                2 Sodium dilution

                                bull Incidence = 45

                                bull After surgery=1

                                bull Mortality = 2 times normal

                                Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                volume deficit

                                Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                Sign and symptoms

                                bull CNS symptom when Nalt123 meql

                                bull Cardiac symptom when Nalt100 meql

                                For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                Body System Hyponatremia

                                central nervous system Headache confusion hyper-or hypoactive deep tendon

                                reflexes seizures coma increased intracranial pressure

                                Musculoskeletal Weakness fatigue muscle crampstwitching

                                Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                Cardiovascular Hypertension and bradycardia if significant increases in

                                intracranial pressure

                                Tissue Lacrimation salivation

                                Renal Oliguria

                                Clinical Manifestations of Abnormalities in Serum Sodium

                                Treatment

                                1=Depend on ECF

                                2=CNS sign

                                Treatment

                                1 Asymptomatic increase the sodium level by no more than

                                05-1 meqLh to a maximum increase of 12 meqL per day

                                2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                more than 1meqL per hour until the serum Na level reaches 130

                                meqL or neurologic symptoms are improved

                                Rapid correction of hyponatremia

                                Pontine myelinolysis

                                Seizures weaknessparesis akinetic

                                movements unresponsiveness

                                Permanent brain damage

                                Death

                                Dose

                                Na deficit meq =(140- Na meql) TBW

                                باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                شود اصالح آهسته سپس

                                Potassium abnormalities

                                bull The average dietary intake of potassium 50-100meqd

                                bull The average renal excretion of potassium 10-700 meqd

                                - 2 of the total body potassium in ECF (45meqL)

                                - Factors that influence serum potassium

                                1 Surgical stress

                                2 Injury

                                3 Acidosis

                                4 Tissue catabolism

                                Hyperkalemia

                                The normal range of serum potassium 35-5 meqL

                                Etiology of Hyperkalemia

                                Increased intake Potassium supplementation

                                Blood transfusions

                                Endogenous loaddestruction

                                hemolysis rhabdomyolysis

                                cruch injury gastrointestinal hemorrhage

                                Increased release Acidosis

                                Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                Renal insufficiencyfailure

                                Clinical manifestation of hyperkalemia

                                System hyperkalemia

                                Gastrointestinal Nauseavomiting colic diarrhea

                                Neuromuscular weakness paralysis respiratory failure

                                Cardiovascular Arrhythmia arrest

                                ECG changes Peaked T waves (early change)

                                Flattened P wave

                                Prolonged PR interval (first-degree block)

                                Widened QRS complex

                                Sine wave formation

                                Ventricular fibrillation

                                Treatment

                                Treatment of symptomatic hyperkalemia

                                Potassium removal Kayexalate

                                Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                Rectal administration is 50 g in 200 mL 20 sorbitol

                                Dialysis

                                Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                Bicarbonate 1 vial intravenous

                                Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                HypokalemiaEtiology

                                inadequate intake

                                Dietary potassium-free intravenous fluids potassium-deficient

                                total parenteral nutrition

                                Excessive potassium excretion

                                Hyperaldosteronism

                                Medications

                                Gastrointestinal losses

                                Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                Renal loss of potassium (gastric fluid either as vomiting or high

                                nasogastric output)

                                Intracellular-shift (metabolic alkalosis or insulin therapy)

                                Potassium changes associated with alkalosis

                                Potassium decrease by 03 meqL for every 01

                                increase in PH above normal

                                Magnesium Depletion

                                (drug induced amphotericin amioglycosides cisplatin)

                                Renal potassium wastage

                                Hypokalemia

                                Magnesium Depletion

                                (drug induced amphotericin amioglycosides cisplatin)

                                Renal potassium wastage

                                Hypokalemia

                                Clinical Manifestation of Abnormalities in potassium

                                System hypokalemia

                                Gastrointestinal Ileus constipation

                                Neuromuscular Decreased reflexes fatigue weakness

                                paralysis

                                Cardiovascular Arrest

                                ECG changes U-waves

                                T-wave flattening

                                ST-segment changes

                                Arrhythmias

                                Treatment

                                Potassium

                                Serum potassium level lt40 mEqL

                                Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                times 1 doses

                                Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                Symptomatic KC1 20 mEq IV q1h times 4 doses

                                Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                asymptomatic replace as per above protocol

                                Electrolyte Replacement Therapy Protocol

                                bull Oral repletion for mild and asymptomatic hypokalemia

                                bull IV repletion for severe and symptomatic hypokalemia

                                Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                ( دندانها( ndash استخوانbull كلسيم نقش

                                عصبي 1 ايمپالسهاي )NMJ(انتقال

                                صاف 2 عضالت انقباض

                                هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                انعقاد 4

                                یونیزه Calt45 meql هيپوكلسمي

                                عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                ( شود می پیوند شده

                                هیپوکلسمی عالئم

                                رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                سایرعالئم

                                قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                درمان

                                ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                Cagt55meql هيپركلسمي

                                هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                عالئم

                                bullGI

                                bullCardiovascular bullRenal (polyuria)

                                bullCNS

                                قلبی عالئم

                                bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                QRS شدن )Q-Tوكوتاه

                                درمان

                                ایزوتونیک 1 نمکی محلول انفوزیون

                                الزیکس2

                                تونین 3 کلسی

                                کورتون4

                                دیالیز5

                                Magnesium Abnormalities

                                Normal dietary intake 20meq (240mg)

                                Excretion in both the feces and urine

                                Normal serum level 19-25 mgdL

                                منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                Hypermagnesemia

                                Etiology

                                1 Impaired renal function

                                2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                Clinical manifestation hypermanesemia

                                System hypermanesemia

                                Gastrointestinal Nauseavomiting

                                Neuromuscular weakness lethargy Decreased

                                reflexes

                                Cardiovascular Hypotension arrest

                                ECG changes Increased PR interval

                                Widened QRS complex

                                Elevated T waves

                                Treatment

                                1 Withhold exogenous sources of magnesium

                                2 Correct volume deficit

                                3 Correct acidosis if present

                                4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                5 Dialysis (if elevated levels or symptoms persist)

                                عالئم

                                bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                meqL

                                Hypomagnesemia

                                Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                homeostasis

                                Etiology

                                1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                inadequate supplementation of magnesium)

                                2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                3 GI losses (diarrhea)

                                4 Malabsorption

                                5 Acute pancreatitis

                                6 Diabetic ketoacidosis

                                7 Primary aldosteronism

                                Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                2 Delirium and seizures in severe deficiency

                                3 ECG changes Prolonged QT and PR interval

                                ST-segment depression

                                Flattening or inversion of P waves

                                Torsades de pointes

                                Arrhythmia

                                Treatment

                                1 For asymptomatic and mild hypomagnesemia administer oral mg

                                2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                Message for Today

                                ICF

                                Interstitial

                                Pla

                                sma

                                5 Dex

                                bull Do not reccussitate sick patients with any Dextrose solution

                                • Fluid and Electrolyte Management of the Surgical Patient
                                • Slide 2
                                • Slide 3
                                • Slide 4
                                • Total Body Water
                                • Body Fluid Compartments
                                • Total body water (TBW)
                                • Body compartment fluid
                                • Example men with 70kg
                                • Fluid compartments
                                • Slide 11
                                • Slide 12
                                • Slide 13
                                • Slide 14
                                • Slide 15
                                • Colloid osmotic pressure
                                • Slide 17
                                • Slide 18
                                • Slide 19
                                • Cell Membrane
                                • Slide 21
                                • Slide 22
                                • Slide 23
                                • Slide 24
                                • Slide 25
                                • Composition of Fluid Compartments
                                • Composition of Body Fluids
                                • عوامل موثر روی تغییرات آب والکترولیت
                                • Reasons for fluid therapy
                                • ارزیابی حجم مایع داخل عروقی
                                • محلولهای وریدی
                                • Fluids
                                • Slide 33
                                • Slide 34
                                • Slide 35
                                • Crystalloids
                                • Colloid Solutions
                                • رینگر لاکتات
                                • 09Nacl
                                • Postoperative (maintenance)
                                • Slide 41
                                • Preexisting fluid deficits
                                • Maintenance requirements
                                • Surgical fluid losses
                                • Third space loss
                                • Crystalloid solution
                                • Colloids
                                • Complications
                                • The Influence of Colloid amp Crystalloid on Blood Volume
                                • Colloid versus crystalloid solutions
                                • Transfusion consideration
                                • اختلال در حجم مایعات بدن
                                • Fluid volume deficit (FVD)
                                • DEHYDRATION
                                • علل کاهش حجم خارج سلولی
                                • Signs of Hypovolemia
                                • Clinical Diagnosis of Hypovolemia
                                • Signs of Hypervolemia
                                • Management of Hypervolemia
                                • Fluid Management
                                • Electrolyte physiology
                                • Sodium physiology
                                • Osmotic Pressure
                                • Concentration
                                • Hypernatremia
                                • - Hypernatremia
                                • Slide 67
                                • Slide 68
                                • Clinical Manifestations of Abnormalities in Serum Sodium
                                • Treatment
                                • Water deficit (L)= times TBW
                                • The rate of fluid administration
                                • Hyponatremia Nalt135mEqL
                                • Slide 74
                                • Sodium depletion
                                • Sodium dilution
                                • Sign and symptoms
                                • Slide 78
                                • Treatment
                                • Slide 80
                                • Slide 81
                                • Dose
                                • Potassium abnormalities
                                • Hyperkalemia
                                • Clinical manifestation of hyperkalemia
                                • Slide 86
                                • Slide 87
                                • Hypokalemia
                                • Potassium changes associated with alkalosis
                                • Slide 90
                                • Clinical Manifestation of Abnormalities in potassium
                                • Slide 92
                                • Calcium
                                • هيپوكلسمي یونیزه Calt45 meql
                                • علائم هیپوکلسمی
                                • Slide 96
                                • Slide 97
                                • Slide 98
                                • Slide 99
                                • سایرعلائم
                                • درمان
                                • هيپركلسمي Cagt55meql
                                • علائم
                                • علائم قلبی
                                • Slide 105
                                • Magnesium Abnormalities
                                • منیزیوم
                                • Hypermagnesemia
                                • Clinical manifestation hypermanesemia
                                • Slide 110
                                • Slide 111
                                • Hypomagnesemia
                                • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                • Slide 114
                                • Message for Today
                                • Slide 116

                                  Colloid osmotic pressure

                                  ECF

                                  Interstitial

                                  Pla

                                  sma

                                  Capillary Membrane

                                  Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                                  Colloid osmotic pressure

                                  ECF

                                  Interstitial

                                  Pla

                                  sma

                                  Capillary Membrane

                                  Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                                  The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                                  H2O

                                  H2O

                                  Colloid osmotic pressure

                                  ECF

                                  Interstitial

                                  Pla

                                  sma

                                  Capillary Membrane

                                  Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                                  The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                                  This is balanced out by the hydrostatic pressure difference

                                  H2O

                                  H2O12080

                                  H2O

                                  H2O

                                  Cell Membrane

                                  ICF

                                  Cell Membrane

                                  Interstitial

                                  H2O

                                  H2O

                                  Cell membrane is freely permeable to H20 but

                                  Cell Membrane

                                  ICF

                                  Cell Membrane

                                  Na+

                                  K+

                                  Interstitial

                                  H2O

                                  H2O

                                  Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                  Cell Membrane

                                  ICF

                                  Cell Membrane

                                  Na-

                                  K+

                                  Interstitial

                                  H2O

                                  H2O

                                  Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                  [K+] =4

                                  Cell Membrane

                                  ICF

                                  Cell Membrane

                                  Na-

                                  K+

                                  Interstitial

                                  H2O

                                  H2O

                                  Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                  [K+] =4 [K+] =150

                                  Cell Membrane

                                  ICF

                                  Cell Membrane

                                  Na-

                                  K+

                                  Interstitial

                                  H2O

                                  H2O

                                  Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                  [K+] =4 [K+] =150

                                  Na+= 144

                                  Cell Membrane

                                  ICF

                                  Cell Membrane

                                  Na-

                                  K+

                                  Interstitial

                                  H2O

                                  H2O

                                  Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                  [K+] =4 [K+] =150

                                  Na+= 144Na+= 10

                                  Composition of Fluid Compartments

                                  CATIONS ANIONS

                                  Na+ 142 Cl - 103

                                  HC03- 27

                                  504mdash

                                  3 PO4

                                  ---

                                  K+ 4 organicCa++ 5 Acid 5

                                  Mg++ 3 Protein 16

                                  CATIONS ANIONS

                                  Na+ 144 Cl - 114

                                  HC03- 30

                                  504mdash

                                  K+ 4 3 PO4

                                  ---

                                  organic

                                  Ca++ 3 Acid 5

                                  Mg++ 2 Protein 1

                                  CATIONS ANIONS

                                  K+ 150 HPO4

                                  150 504

                                  mdash

                                  HCO3- 10

                                  Mg++ 40 Protein 40

                                  Na+ 10

                                  154 mEqL 153 mEqL 153 mEqL154 mEqL

                                  PLASMA INTERSTITAL FLID

                                  200 mEqL 200 mEqL

                                  INTRACELLULAR FLID

                                  Composition of Body FluidsComposition of Body Fluids

                                  Ca 2+

                                  Mg 2+

                                  K+

                                  Na+

                                  Cl-

                                  PO43-

                                  Organic anion

                                  HCO3-

                                  Protein

                                  0

                                  50

                                  50

                                  100

                                  150

                                  100

                                  150

                                  Cations Anions

                                  EC

                                  FICF

                                  Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                                  والکترولیت آب تغییرات روی موثر عوامل

                                  1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                                  عمل 2 از قبل والکترولیت آب وضعیت

                                  اندوکرینوپاتی )3 همراه )بیماریهای

                                  4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                                  Reasons for fluid therapyReasons for fluid therapy

                                  Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                                  bull Correct hypovolaemiaCorrect hypovolaemia

                                  bull Maintain cardiac outputMaintain cardiac output

                                  bull Optimise gas exchangeOptimise gas exchange

                                  bull Replace electrolytes amp waterReplace electrolytes amp water

                                  bull Maintain urine outputMaintain urine output

                                  Colloids + RBCs

                                  Crystalloids

                                  Identify what is the goal

                                  Choose fluid which best achieves the goal

                                  عروقی داخل مایع حجم ارزیابی

                                  بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                                  وریدی محلولهای

                                  Fluids bull Crystalloids

                                  bull Colloids

                                  bull blood

                                  Which of the following solutions is isotonic

                                  A D5W

                                  B 045 saline

                                  C 09 saline

                                  D D5 in 09 saline

                                  SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                                  ECFECF 142 4 5 103 27 280-310

                                  Lactated Lactated RingerrsquosRingerrsquos

                                  130 4 3 109 28 273

                                  09 NaCl09 NaCl 154 154 308

                                  045 045 NaClNaCl

                                  77 77 154

                                  D5WD5W

                                  D5045 D5045 NaClNaCl

                                  77 77 50 406

                                  3 NaCl3 NaCl 513 513 1026

                                  6 6 HetastarchHetastarch

                                  500 154 154 310

                                  5 5 AlbuminAlbumin

                                  250500130-160

                                  lt25130-160

                                  330

                                  25 25 AlbuminAlbumin

                                  2050100130-160

                                  lt25130-160

                                  330

                                  Common parenteral fluid therapyCommon parenteral fluid therapy

                                  CrystalloidsCrystalloids

                                  bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                  Colloid SolutionsColloid Solutions

                                  bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                  - Haes-steril 10

                                  الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                  کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                  ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                  osm=273

                                  09Nacl

                                  bull Na=154

                                  bull CL= 154

                                  کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                  PH=56است

                                  Postoperative (maintenance)

                                  045Nacl +5 dextrose +KCL

                                  Perioperative management of fluid balance include

                                  1 Preoperative evaluation

                                  2 Intraoperative maintenance

                                  3 Replacement of fluid losses

                                  Preexisting fluid deficits

                                  bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                  bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                  Maintenance requirements

                                  bull Up to 10 kg = 4cckghr

                                  bull 11-20kg = add 2cckghr

                                  bull 21kg and above = add 1cckghr

                                  bull Insensible losses = 2cckghr

                                  Surgical fluid losses

                                  Blood loss (measurement)

                                  1 Suction container

                                  2 Surgical sponge

                                  3 Hct and tachycardia not specific

                                  4 ABG and UO if hypoperfusion occur

                                  5 Blood loss=31 with crystalloid

                                  Other losses (third space loss)

                                  Third space loss

                                  1 Minimal (herniorrapy) =2-4cckghr

                                  2 Moderate (cholecystectomy)=4-6cckghr

                                  3 Severe (bowel resection) = 6-8cckghr

                                  Crystalloid solution

                                  1 The main solutions is either glucose or saline

                                  2 Hypotonic or isotonic or hypertonic

                                  3 Safe nontoxic reaction free inexpensive

                                  4 Complication is edema if large volumes are needed

                                  5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                  Colloids

                                  1 Albumin

                                  2 Hydroxyethyl starch

                                  3 Dextran

                                  Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                  factor )These colloid is best avoided in patients with

                                  coagulopaty

                                  The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                  1000cc

                                  500cc

                                  500cc

                                  500cc

                                  200

                                  600

                                  1000

                                  Lactated Ringers

                                  5 Albumin

                                  6 Hetastarch

                                  Whole blood

                                  Blood volumeInfusion volume

                                  Colloid versus crystalloid solutions

                                  Transfusion consideration

                                  bull HB lt7 mg dl increase CO

                                  bull Ideal Hb is 7-8 mgdl

                                  bull In IHD patients or pulmonary disease gt 10 mgdl

                                  بدن مایعات حجم در اختالل

                                  1 Fluid volume deficit

                                  2 Fluid volume excess

                                  Fluid volume deficit(FVD)

                                  ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                  کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                  ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                  باشد آن با همراه دیگری اختالل مگر

                                  DEHYDRATION

                                  سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                  سلولی خارج حجم کاهش علل

                                  1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                  2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                  کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                  Signs of HypovolemiaSigns of Hypovolemia

                                  bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                  Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                  bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                  Signs of HypervolemiaSigns of Hypervolemia

                                  bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                  Especially when hypo-albuminemia

                                  Management of Management of HypervolemiaHypervolemia

                                  bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                  Fluid ManagementFluid Management

                                  bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                  Electrolyte physiology

                                  Sodium physiology

                                  Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                  Normal amount 135-145 meql

                                  Osmotic Pressure

                                  Calculated serum osmolality =

                                  2 sodium+ glucose18 + BUN 28

                                  Osmolality = 290 mosm

                                  Concentration

                                  1Serum sodium concentration2Serum osmolarity

                                  bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                  drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                  DW5)

                                  Hypernatremia

                                  Serum Nagt145mEqL

                                  - Hypernatremia

                                  Loss of Free Water

                                  Gain of sodium in excess of water

                                  Hypernatremia

                                  -Hypernatremia Hypo volemic

                                  Hyper volemic

                                  Normo volemic

                                  Hypernatremia

                                  Volume Status

                                  Normal

                                  Nonrenal water loss

                                  Skin

                                  Gastrointestinal

                                  Renal water loss

                                  Renal disease

                                  Diuretics

                                  Diabetes insipidus

                                  High

                                  Iatrogenic sodium administration

                                  Mineralocorticoid excess

                                  Aldosteronism

                                  Cushingrsquos disease

                                  Congenital adrenal

                                  hyperplasia

                                  Low

                                  Nonrenal water loss

                                  Skin

                                  Gastrointestinal losses

                                  Renal water losses

                                  Renal (tubular) Diuretics

                                  Osmotic diuretics

                                  Diabetes insipidus

                                  Adrenal failure

                                  Asymptomatic

                                  Hypernatremia Symptomatic (Nagt160 meqL)

                                  Clinical Manifestations of Abnormalities in Serum Sodium

                                  Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                  Body system hypernatremia

                                  Treatment

                                  Normal saline in hypovolemic patients

                                  Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                  saline or entral water)

                                  Water deficit (L)= times TBW

                                  The formula used to estimate the amount of water required to correct hypernatremia

                                  Estimate TBW as 55 of lean body mass in men and 45 in women

                                  Serum sodium-140

                                  140

                                  The rate of fluid administration

                                  1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                  2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                  Hyponatremia Nalt135mEqL

                                  Causes

                                  1 Sodium depletion

                                  2 Sodium dilution

                                  bull Incidence = 45

                                  bull After surgery=1

                                  bull Mortality = 2 times normal

                                  Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                  volume deficit

                                  Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                  Sign and symptoms

                                  bull CNS symptom when Nalt123 meql

                                  bull Cardiac symptom when Nalt100 meql

                                  For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                  Body System Hyponatremia

                                  central nervous system Headache confusion hyper-or hypoactive deep tendon

                                  reflexes seizures coma increased intracranial pressure

                                  Musculoskeletal Weakness fatigue muscle crampstwitching

                                  Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                  Cardiovascular Hypertension and bradycardia if significant increases in

                                  intracranial pressure

                                  Tissue Lacrimation salivation

                                  Renal Oliguria

                                  Clinical Manifestations of Abnormalities in Serum Sodium

                                  Treatment

                                  1=Depend on ECF

                                  2=CNS sign

                                  Treatment

                                  1 Asymptomatic increase the sodium level by no more than

                                  05-1 meqLh to a maximum increase of 12 meqL per day

                                  2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                  more than 1meqL per hour until the serum Na level reaches 130

                                  meqL or neurologic symptoms are improved

                                  Rapid correction of hyponatremia

                                  Pontine myelinolysis

                                  Seizures weaknessparesis akinetic

                                  movements unresponsiveness

                                  Permanent brain damage

                                  Death

                                  Dose

                                  Na deficit meq =(140- Na meql) TBW

                                  باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                  شود اصالح آهسته سپس

                                  Potassium abnormalities

                                  bull The average dietary intake of potassium 50-100meqd

                                  bull The average renal excretion of potassium 10-700 meqd

                                  - 2 of the total body potassium in ECF (45meqL)

                                  - Factors that influence serum potassium

                                  1 Surgical stress

                                  2 Injury

                                  3 Acidosis

                                  4 Tissue catabolism

                                  Hyperkalemia

                                  The normal range of serum potassium 35-5 meqL

                                  Etiology of Hyperkalemia

                                  Increased intake Potassium supplementation

                                  Blood transfusions

                                  Endogenous loaddestruction

                                  hemolysis rhabdomyolysis

                                  cruch injury gastrointestinal hemorrhage

                                  Increased release Acidosis

                                  Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                  Renal insufficiencyfailure

                                  Clinical manifestation of hyperkalemia

                                  System hyperkalemia

                                  Gastrointestinal Nauseavomiting colic diarrhea

                                  Neuromuscular weakness paralysis respiratory failure

                                  Cardiovascular Arrhythmia arrest

                                  ECG changes Peaked T waves (early change)

                                  Flattened P wave

                                  Prolonged PR interval (first-degree block)

                                  Widened QRS complex

                                  Sine wave formation

                                  Ventricular fibrillation

                                  Treatment

                                  Treatment of symptomatic hyperkalemia

                                  Potassium removal Kayexalate

                                  Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                  Rectal administration is 50 g in 200 mL 20 sorbitol

                                  Dialysis

                                  Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                  Bicarbonate 1 vial intravenous

                                  Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                  HypokalemiaEtiology

                                  inadequate intake

                                  Dietary potassium-free intravenous fluids potassium-deficient

                                  total parenteral nutrition

                                  Excessive potassium excretion

                                  Hyperaldosteronism

                                  Medications

                                  Gastrointestinal losses

                                  Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                  Renal loss of potassium (gastric fluid either as vomiting or high

                                  nasogastric output)

                                  Intracellular-shift (metabolic alkalosis or insulin therapy)

                                  Potassium changes associated with alkalosis

                                  Potassium decrease by 03 meqL for every 01

                                  increase in PH above normal

                                  Magnesium Depletion

                                  (drug induced amphotericin amioglycosides cisplatin)

                                  Renal potassium wastage

                                  Hypokalemia

                                  Magnesium Depletion

                                  (drug induced amphotericin amioglycosides cisplatin)

                                  Renal potassium wastage

                                  Hypokalemia

                                  Clinical Manifestation of Abnormalities in potassium

                                  System hypokalemia

                                  Gastrointestinal Ileus constipation

                                  Neuromuscular Decreased reflexes fatigue weakness

                                  paralysis

                                  Cardiovascular Arrest

                                  ECG changes U-waves

                                  T-wave flattening

                                  ST-segment changes

                                  Arrhythmias

                                  Treatment

                                  Potassium

                                  Serum potassium level lt40 mEqL

                                  Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                  times 1 doses

                                  Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                  Symptomatic KC1 20 mEq IV q1h times 4 doses

                                  Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                  asymptomatic replace as per above protocol

                                  Electrolyte Replacement Therapy Protocol

                                  bull Oral repletion for mild and asymptomatic hypokalemia

                                  bull IV repletion for severe and symptomatic hypokalemia

                                  Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                  ( دندانها( ndash استخوانbull كلسيم نقش

                                  عصبي 1 ايمپالسهاي )NMJ(انتقال

                                  صاف 2 عضالت انقباض

                                  هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                  انعقاد 4

                                  یونیزه Calt45 meql هيپوكلسمي

                                  عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                  ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                  میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                  ( شود می پیوند شده

                                  هیپوکلسمی عالئم

                                  رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                  سایرعالئم

                                  قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                  درمان

                                  ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                  Cagt55meql هيپركلسمي

                                  هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                  عالئم

                                  bullGI

                                  bullCardiovascular bullRenal (polyuria)

                                  bullCNS

                                  قلبی عالئم

                                  bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                  QRS شدن )Q-Tوكوتاه

                                  درمان

                                  ایزوتونیک 1 نمکی محلول انفوزیون

                                  الزیکس2

                                  تونین 3 کلسی

                                  کورتون4

                                  دیالیز5

                                  Magnesium Abnormalities

                                  Normal dietary intake 20meq (240mg)

                                  Excretion in both the feces and urine

                                  Normal serum level 19-25 mgdL

                                  منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                  تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                  bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                  Hypermagnesemia

                                  Etiology

                                  1 Impaired renal function

                                  2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                  Clinical manifestation hypermanesemia

                                  System hypermanesemia

                                  Gastrointestinal Nauseavomiting

                                  Neuromuscular weakness lethargy Decreased

                                  reflexes

                                  Cardiovascular Hypotension arrest

                                  ECG changes Increased PR interval

                                  Widened QRS complex

                                  Elevated T waves

                                  Treatment

                                  1 Withhold exogenous sources of magnesium

                                  2 Correct volume deficit

                                  3 Correct acidosis if present

                                  4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                  5 Dialysis (if elevated levels or symptoms persist)

                                  عالئم

                                  bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                  meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                  meqL

                                  Hypomagnesemia

                                  Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                  homeostasis

                                  Etiology

                                  1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                  inadequate supplementation of magnesium)

                                  2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                  3 GI losses (diarrhea)

                                  4 Malabsorption

                                  5 Acute pancreatitis

                                  6 Diabetic ketoacidosis

                                  7 Primary aldosteronism

                                  Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                  1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                  2 Delirium and seizures in severe deficiency

                                  3 ECG changes Prolonged QT and PR interval

                                  ST-segment depression

                                  Flattening or inversion of P waves

                                  Torsades de pointes

                                  Arrhythmia

                                  Treatment

                                  1 For asymptomatic and mild hypomagnesemia administer oral mg

                                  2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                  Message for Today

                                  ICF

                                  Interstitial

                                  Pla

                                  sma

                                  5 Dex

                                  bull Do not reccussitate sick patients with any Dextrose solution

                                  • Fluid and Electrolyte Management of the Surgical Patient
                                  • Slide 2
                                  • Slide 3
                                  • Slide 4
                                  • Total Body Water
                                  • Body Fluid Compartments
                                  • Total body water (TBW)
                                  • Body compartment fluid
                                  • Example men with 70kg
                                  • Fluid compartments
                                  • Slide 11
                                  • Slide 12
                                  • Slide 13
                                  • Slide 14
                                  • Slide 15
                                  • Colloid osmotic pressure
                                  • Slide 17
                                  • Slide 18
                                  • Slide 19
                                  • Cell Membrane
                                  • Slide 21
                                  • Slide 22
                                  • Slide 23
                                  • Slide 24
                                  • Slide 25
                                  • Composition of Fluid Compartments
                                  • Composition of Body Fluids
                                  • عوامل موثر روی تغییرات آب والکترولیت
                                  • Reasons for fluid therapy
                                  • ارزیابی حجم مایع داخل عروقی
                                  • محلولهای وریدی
                                  • Fluids
                                  • Slide 33
                                  • Slide 34
                                  • Slide 35
                                  • Crystalloids
                                  • Colloid Solutions
                                  • رینگر لاکتات
                                  • 09Nacl
                                  • Postoperative (maintenance)
                                  • Slide 41
                                  • Preexisting fluid deficits
                                  • Maintenance requirements
                                  • Surgical fluid losses
                                  • Third space loss
                                  • Crystalloid solution
                                  • Colloids
                                  • Complications
                                  • The Influence of Colloid amp Crystalloid on Blood Volume
                                  • Colloid versus crystalloid solutions
                                  • Transfusion consideration
                                  • اختلال در حجم مایعات بدن
                                  • Fluid volume deficit (FVD)
                                  • DEHYDRATION
                                  • علل کاهش حجم خارج سلولی
                                  • Signs of Hypovolemia
                                  • Clinical Diagnosis of Hypovolemia
                                  • Signs of Hypervolemia
                                  • Management of Hypervolemia
                                  • Fluid Management
                                  • Electrolyte physiology
                                  • Sodium physiology
                                  • Osmotic Pressure
                                  • Concentration
                                  • Hypernatremia
                                  • - Hypernatremia
                                  • Slide 67
                                  • Slide 68
                                  • Clinical Manifestations of Abnormalities in Serum Sodium
                                  • Treatment
                                  • Water deficit (L)= times TBW
                                  • The rate of fluid administration
                                  • Hyponatremia Nalt135mEqL
                                  • Slide 74
                                  • Sodium depletion
                                  • Sodium dilution
                                  • Sign and symptoms
                                  • Slide 78
                                  • Treatment
                                  • Slide 80
                                  • Slide 81
                                  • Dose
                                  • Potassium abnormalities
                                  • Hyperkalemia
                                  • Clinical manifestation of hyperkalemia
                                  • Slide 86
                                  • Slide 87
                                  • Hypokalemia
                                  • Potassium changes associated with alkalosis
                                  • Slide 90
                                  • Clinical Manifestation of Abnormalities in potassium
                                  • Slide 92
                                  • Calcium
                                  • هيپوكلسمي یونیزه Calt45 meql
                                  • علائم هیپوکلسمی
                                  • Slide 96
                                  • Slide 97
                                  • Slide 98
                                  • Slide 99
                                  • سایرعلائم
                                  • درمان
                                  • هيپركلسمي Cagt55meql
                                  • علائم
                                  • علائم قلبی
                                  • Slide 105
                                  • Magnesium Abnormalities
                                  • منیزیوم
                                  • Hypermagnesemia
                                  • Clinical manifestation hypermanesemia
                                  • Slide 110
                                  • Slide 111
                                  • Hypomagnesemia
                                  • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                  • Slide 114
                                  • Message for Today
                                  • Slide 116

                                    Colloid osmotic pressure

                                    ECF

                                    Interstitial

                                    Pla

                                    sma

                                    Capillary Membrane

                                    Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                                    The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                                    H2O

                                    H2O

                                    Colloid osmotic pressure

                                    ECF

                                    Interstitial

                                    Pla

                                    sma

                                    Capillary Membrane

                                    Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                                    The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                                    This is balanced out by the hydrostatic pressure difference

                                    H2O

                                    H2O12080

                                    H2O

                                    H2O

                                    Cell Membrane

                                    ICF

                                    Cell Membrane

                                    Interstitial

                                    H2O

                                    H2O

                                    Cell membrane is freely permeable to H20 but

                                    Cell Membrane

                                    ICF

                                    Cell Membrane

                                    Na+

                                    K+

                                    Interstitial

                                    H2O

                                    H2O

                                    Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                    Cell Membrane

                                    ICF

                                    Cell Membrane

                                    Na-

                                    K+

                                    Interstitial

                                    H2O

                                    H2O

                                    Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                    [K+] =4

                                    Cell Membrane

                                    ICF

                                    Cell Membrane

                                    Na-

                                    K+

                                    Interstitial

                                    H2O

                                    H2O

                                    Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                    [K+] =4 [K+] =150

                                    Cell Membrane

                                    ICF

                                    Cell Membrane

                                    Na-

                                    K+

                                    Interstitial

                                    H2O

                                    H2O

                                    Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                    [K+] =4 [K+] =150

                                    Na+= 144

                                    Cell Membrane

                                    ICF

                                    Cell Membrane

                                    Na-

                                    K+

                                    Interstitial

                                    H2O

                                    H2O

                                    Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                    [K+] =4 [K+] =150

                                    Na+= 144Na+= 10

                                    Composition of Fluid Compartments

                                    CATIONS ANIONS

                                    Na+ 142 Cl - 103

                                    HC03- 27

                                    504mdash

                                    3 PO4

                                    ---

                                    K+ 4 organicCa++ 5 Acid 5

                                    Mg++ 3 Protein 16

                                    CATIONS ANIONS

                                    Na+ 144 Cl - 114

                                    HC03- 30

                                    504mdash

                                    K+ 4 3 PO4

                                    ---

                                    organic

                                    Ca++ 3 Acid 5

                                    Mg++ 2 Protein 1

                                    CATIONS ANIONS

                                    K+ 150 HPO4

                                    150 504

                                    mdash

                                    HCO3- 10

                                    Mg++ 40 Protein 40

                                    Na+ 10

                                    154 mEqL 153 mEqL 153 mEqL154 mEqL

                                    PLASMA INTERSTITAL FLID

                                    200 mEqL 200 mEqL

                                    INTRACELLULAR FLID

                                    Composition of Body FluidsComposition of Body Fluids

                                    Ca 2+

                                    Mg 2+

                                    K+

                                    Na+

                                    Cl-

                                    PO43-

                                    Organic anion

                                    HCO3-

                                    Protein

                                    0

                                    50

                                    50

                                    100

                                    150

                                    100

                                    150

                                    Cations Anions

                                    EC

                                    FICF

                                    Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                                    والکترولیت آب تغییرات روی موثر عوامل

                                    1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                                    عمل 2 از قبل والکترولیت آب وضعیت

                                    اندوکرینوپاتی )3 همراه )بیماریهای

                                    4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                                    Reasons for fluid therapyReasons for fluid therapy

                                    Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                                    bull Correct hypovolaemiaCorrect hypovolaemia

                                    bull Maintain cardiac outputMaintain cardiac output

                                    bull Optimise gas exchangeOptimise gas exchange

                                    bull Replace electrolytes amp waterReplace electrolytes amp water

                                    bull Maintain urine outputMaintain urine output

                                    Colloids + RBCs

                                    Crystalloids

                                    Identify what is the goal

                                    Choose fluid which best achieves the goal

                                    عروقی داخل مایع حجم ارزیابی

                                    بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                                    وریدی محلولهای

                                    Fluids bull Crystalloids

                                    bull Colloids

                                    bull blood

                                    Which of the following solutions is isotonic

                                    A D5W

                                    B 045 saline

                                    C 09 saline

                                    D D5 in 09 saline

                                    SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                                    ECFECF 142 4 5 103 27 280-310

                                    Lactated Lactated RingerrsquosRingerrsquos

                                    130 4 3 109 28 273

                                    09 NaCl09 NaCl 154 154 308

                                    045 045 NaClNaCl

                                    77 77 154

                                    D5WD5W

                                    D5045 D5045 NaClNaCl

                                    77 77 50 406

                                    3 NaCl3 NaCl 513 513 1026

                                    6 6 HetastarchHetastarch

                                    500 154 154 310

                                    5 5 AlbuminAlbumin

                                    250500130-160

                                    lt25130-160

                                    330

                                    25 25 AlbuminAlbumin

                                    2050100130-160

                                    lt25130-160

                                    330

                                    Common parenteral fluid therapyCommon parenteral fluid therapy

                                    CrystalloidsCrystalloids

                                    bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                    Colloid SolutionsColloid Solutions

                                    bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                    - Haes-steril 10

                                    الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                    کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                    ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                    osm=273

                                    09Nacl

                                    bull Na=154

                                    bull CL= 154

                                    کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                    PH=56است

                                    Postoperative (maintenance)

                                    045Nacl +5 dextrose +KCL

                                    Perioperative management of fluid balance include

                                    1 Preoperative evaluation

                                    2 Intraoperative maintenance

                                    3 Replacement of fluid losses

                                    Preexisting fluid deficits

                                    bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                    bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                    Maintenance requirements

                                    bull Up to 10 kg = 4cckghr

                                    bull 11-20kg = add 2cckghr

                                    bull 21kg and above = add 1cckghr

                                    bull Insensible losses = 2cckghr

                                    Surgical fluid losses

                                    Blood loss (measurement)

                                    1 Suction container

                                    2 Surgical sponge

                                    3 Hct and tachycardia not specific

                                    4 ABG and UO if hypoperfusion occur

                                    5 Blood loss=31 with crystalloid

                                    Other losses (third space loss)

                                    Third space loss

                                    1 Minimal (herniorrapy) =2-4cckghr

                                    2 Moderate (cholecystectomy)=4-6cckghr

                                    3 Severe (bowel resection) = 6-8cckghr

                                    Crystalloid solution

                                    1 The main solutions is either glucose or saline

                                    2 Hypotonic or isotonic or hypertonic

                                    3 Safe nontoxic reaction free inexpensive

                                    4 Complication is edema if large volumes are needed

                                    5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                    Colloids

                                    1 Albumin

                                    2 Hydroxyethyl starch

                                    3 Dextran

                                    Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                    factor )These colloid is best avoided in patients with

                                    coagulopaty

                                    The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                    1000cc

                                    500cc

                                    500cc

                                    500cc

                                    200

                                    600

                                    1000

                                    Lactated Ringers

                                    5 Albumin

                                    6 Hetastarch

                                    Whole blood

                                    Blood volumeInfusion volume

                                    Colloid versus crystalloid solutions

                                    Transfusion consideration

                                    bull HB lt7 mg dl increase CO

                                    bull Ideal Hb is 7-8 mgdl

                                    bull In IHD patients or pulmonary disease gt 10 mgdl

                                    بدن مایعات حجم در اختالل

                                    1 Fluid volume deficit

                                    2 Fluid volume excess

                                    Fluid volume deficit(FVD)

                                    ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                    کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                    ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                    باشد آن با همراه دیگری اختالل مگر

                                    DEHYDRATION

                                    سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                    سلولی خارج حجم کاهش علل

                                    1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                    2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                    کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                    Signs of HypovolemiaSigns of Hypovolemia

                                    bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                    Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                    bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                    Signs of HypervolemiaSigns of Hypervolemia

                                    bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                    Especially when hypo-albuminemia

                                    Management of Management of HypervolemiaHypervolemia

                                    bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                    Fluid ManagementFluid Management

                                    bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                    Electrolyte physiology

                                    Sodium physiology

                                    Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                    Normal amount 135-145 meql

                                    Osmotic Pressure

                                    Calculated serum osmolality =

                                    2 sodium+ glucose18 + BUN 28

                                    Osmolality = 290 mosm

                                    Concentration

                                    1Serum sodium concentration2Serum osmolarity

                                    bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                    drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                    DW5)

                                    Hypernatremia

                                    Serum Nagt145mEqL

                                    - Hypernatremia

                                    Loss of Free Water

                                    Gain of sodium in excess of water

                                    Hypernatremia

                                    -Hypernatremia Hypo volemic

                                    Hyper volemic

                                    Normo volemic

                                    Hypernatremia

                                    Volume Status

                                    Normal

                                    Nonrenal water loss

                                    Skin

                                    Gastrointestinal

                                    Renal water loss

                                    Renal disease

                                    Diuretics

                                    Diabetes insipidus

                                    High

                                    Iatrogenic sodium administration

                                    Mineralocorticoid excess

                                    Aldosteronism

                                    Cushingrsquos disease

                                    Congenital adrenal

                                    hyperplasia

                                    Low

                                    Nonrenal water loss

                                    Skin

                                    Gastrointestinal losses

                                    Renal water losses

                                    Renal (tubular) Diuretics

                                    Osmotic diuretics

                                    Diabetes insipidus

                                    Adrenal failure

                                    Asymptomatic

                                    Hypernatremia Symptomatic (Nagt160 meqL)

                                    Clinical Manifestations of Abnormalities in Serum Sodium

                                    Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                    Body system hypernatremia

                                    Treatment

                                    Normal saline in hypovolemic patients

                                    Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                    saline or entral water)

                                    Water deficit (L)= times TBW

                                    The formula used to estimate the amount of water required to correct hypernatremia

                                    Estimate TBW as 55 of lean body mass in men and 45 in women

                                    Serum sodium-140

                                    140

                                    The rate of fluid administration

                                    1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                    2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                    Hyponatremia Nalt135mEqL

                                    Causes

                                    1 Sodium depletion

                                    2 Sodium dilution

                                    bull Incidence = 45

                                    bull After surgery=1

                                    bull Mortality = 2 times normal

                                    Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                    volume deficit

                                    Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                    Sign and symptoms

                                    bull CNS symptom when Nalt123 meql

                                    bull Cardiac symptom when Nalt100 meql

                                    For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                    Body System Hyponatremia

                                    central nervous system Headache confusion hyper-or hypoactive deep tendon

                                    reflexes seizures coma increased intracranial pressure

                                    Musculoskeletal Weakness fatigue muscle crampstwitching

                                    Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                    Cardiovascular Hypertension and bradycardia if significant increases in

                                    intracranial pressure

                                    Tissue Lacrimation salivation

                                    Renal Oliguria

                                    Clinical Manifestations of Abnormalities in Serum Sodium

                                    Treatment

                                    1=Depend on ECF

                                    2=CNS sign

                                    Treatment

                                    1 Asymptomatic increase the sodium level by no more than

                                    05-1 meqLh to a maximum increase of 12 meqL per day

                                    2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                    more than 1meqL per hour until the serum Na level reaches 130

                                    meqL or neurologic symptoms are improved

                                    Rapid correction of hyponatremia

                                    Pontine myelinolysis

                                    Seizures weaknessparesis akinetic

                                    movements unresponsiveness

                                    Permanent brain damage

                                    Death

                                    Dose

                                    Na deficit meq =(140- Na meql) TBW

                                    باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                    شود اصالح آهسته سپس

                                    Potassium abnormalities

                                    bull The average dietary intake of potassium 50-100meqd

                                    bull The average renal excretion of potassium 10-700 meqd

                                    - 2 of the total body potassium in ECF (45meqL)

                                    - Factors that influence serum potassium

                                    1 Surgical stress

                                    2 Injury

                                    3 Acidosis

                                    4 Tissue catabolism

                                    Hyperkalemia

                                    The normal range of serum potassium 35-5 meqL

                                    Etiology of Hyperkalemia

                                    Increased intake Potassium supplementation

                                    Blood transfusions

                                    Endogenous loaddestruction

                                    hemolysis rhabdomyolysis

                                    cruch injury gastrointestinal hemorrhage

                                    Increased release Acidosis

                                    Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                    Renal insufficiencyfailure

                                    Clinical manifestation of hyperkalemia

                                    System hyperkalemia

                                    Gastrointestinal Nauseavomiting colic diarrhea

                                    Neuromuscular weakness paralysis respiratory failure

                                    Cardiovascular Arrhythmia arrest

                                    ECG changes Peaked T waves (early change)

                                    Flattened P wave

                                    Prolonged PR interval (first-degree block)

                                    Widened QRS complex

                                    Sine wave formation

                                    Ventricular fibrillation

                                    Treatment

                                    Treatment of symptomatic hyperkalemia

                                    Potassium removal Kayexalate

                                    Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                    Rectal administration is 50 g in 200 mL 20 sorbitol

                                    Dialysis

                                    Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                    Bicarbonate 1 vial intravenous

                                    Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                    HypokalemiaEtiology

                                    inadequate intake

                                    Dietary potassium-free intravenous fluids potassium-deficient

                                    total parenteral nutrition

                                    Excessive potassium excretion

                                    Hyperaldosteronism

                                    Medications

                                    Gastrointestinal losses

                                    Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                    Renal loss of potassium (gastric fluid either as vomiting or high

                                    nasogastric output)

                                    Intracellular-shift (metabolic alkalosis or insulin therapy)

                                    Potassium changes associated with alkalosis

                                    Potassium decrease by 03 meqL for every 01

                                    increase in PH above normal

                                    Magnesium Depletion

                                    (drug induced amphotericin amioglycosides cisplatin)

                                    Renal potassium wastage

                                    Hypokalemia

                                    Magnesium Depletion

                                    (drug induced amphotericin amioglycosides cisplatin)

                                    Renal potassium wastage

                                    Hypokalemia

                                    Clinical Manifestation of Abnormalities in potassium

                                    System hypokalemia

                                    Gastrointestinal Ileus constipation

                                    Neuromuscular Decreased reflexes fatigue weakness

                                    paralysis

                                    Cardiovascular Arrest

                                    ECG changes U-waves

                                    T-wave flattening

                                    ST-segment changes

                                    Arrhythmias

                                    Treatment

                                    Potassium

                                    Serum potassium level lt40 mEqL

                                    Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                    times 1 doses

                                    Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                    Symptomatic KC1 20 mEq IV q1h times 4 doses

                                    Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                    asymptomatic replace as per above protocol

                                    Electrolyte Replacement Therapy Protocol

                                    bull Oral repletion for mild and asymptomatic hypokalemia

                                    bull IV repletion for severe and symptomatic hypokalemia

                                    Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                    ( دندانها( ndash استخوانbull كلسيم نقش

                                    عصبي 1 ايمپالسهاي )NMJ(انتقال

                                    صاف 2 عضالت انقباض

                                    هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                    انعقاد 4

                                    یونیزه Calt45 meql هيپوكلسمي

                                    عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                    ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                    میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                    ( شود می پیوند شده

                                    هیپوکلسمی عالئم

                                    رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                    سایرعالئم

                                    قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                    درمان

                                    ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                    Cagt55meql هيپركلسمي

                                    هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                    عالئم

                                    bullGI

                                    bullCardiovascular bullRenal (polyuria)

                                    bullCNS

                                    قلبی عالئم

                                    bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                    QRS شدن )Q-Tوكوتاه

                                    درمان

                                    ایزوتونیک 1 نمکی محلول انفوزیون

                                    الزیکس2

                                    تونین 3 کلسی

                                    کورتون4

                                    دیالیز5

                                    Magnesium Abnormalities

                                    Normal dietary intake 20meq (240mg)

                                    Excretion in both the feces and urine

                                    Normal serum level 19-25 mgdL

                                    منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                    تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                    bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                    Hypermagnesemia

                                    Etiology

                                    1 Impaired renal function

                                    2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                    Clinical manifestation hypermanesemia

                                    System hypermanesemia

                                    Gastrointestinal Nauseavomiting

                                    Neuromuscular weakness lethargy Decreased

                                    reflexes

                                    Cardiovascular Hypotension arrest

                                    ECG changes Increased PR interval

                                    Widened QRS complex

                                    Elevated T waves

                                    Treatment

                                    1 Withhold exogenous sources of magnesium

                                    2 Correct volume deficit

                                    3 Correct acidosis if present

                                    4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                    5 Dialysis (if elevated levels or symptoms persist)

                                    عالئم

                                    bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                    meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                    meqL

                                    Hypomagnesemia

                                    Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                    homeostasis

                                    Etiology

                                    1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                    inadequate supplementation of magnesium)

                                    2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                    3 GI losses (diarrhea)

                                    4 Malabsorption

                                    5 Acute pancreatitis

                                    6 Diabetic ketoacidosis

                                    7 Primary aldosteronism

                                    Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                    1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                    2 Delirium and seizures in severe deficiency

                                    3 ECG changes Prolonged QT and PR interval

                                    ST-segment depression

                                    Flattening or inversion of P waves

                                    Torsades de pointes

                                    Arrhythmia

                                    Treatment

                                    1 For asymptomatic and mild hypomagnesemia administer oral mg

                                    2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                    Message for Today

                                    ICF

                                    Interstitial

                                    Pla

                                    sma

                                    5 Dex

                                    bull Do not reccussitate sick patients with any Dextrose solution

                                    • Fluid and Electrolyte Management of the Surgical Patient
                                    • Slide 2
                                    • Slide 3
                                    • Slide 4
                                    • Total Body Water
                                    • Body Fluid Compartments
                                    • Total body water (TBW)
                                    • Body compartment fluid
                                    • Example men with 70kg
                                    • Fluid compartments
                                    • Slide 11
                                    • Slide 12
                                    • Slide 13
                                    • Slide 14
                                    • Slide 15
                                    • Colloid osmotic pressure
                                    • Slide 17
                                    • Slide 18
                                    • Slide 19
                                    • Cell Membrane
                                    • Slide 21
                                    • Slide 22
                                    • Slide 23
                                    • Slide 24
                                    • Slide 25
                                    • Composition of Fluid Compartments
                                    • Composition of Body Fluids
                                    • عوامل موثر روی تغییرات آب والکترولیت
                                    • Reasons for fluid therapy
                                    • ارزیابی حجم مایع داخل عروقی
                                    • محلولهای وریدی
                                    • Fluids
                                    • Slide 33
                                    • Slide 34
                                    • Slide 35
                                    • Crystalloids
                                    • Colloid Solutions
                                    • رینگر لاکتات
                                    • 09Nacl
                                    • Postoperative (maintenance)
                                    • Slide 41
                                    • Preexisting fluid deficits
                                    • Maintenance requirements
                                    • Surgical fluid losses
                                    • Third space loss
                                    • Crystalloid solution
                                    • Colloids
                                    • Complications
                                    • The Influence of Colloid amp Crystalloid on Blood Volume
                                    • Colloid versus crystalloid solutions
                                    • Transfusion consideration
                                    • اختلال در حجم مایعات بدن
                                    • Fluid volume deficit (FVD)
                                    • DEHYDRATION
                                    • علل کاهش حجم خارج سلولی
                                    • Signs of Hypovolemia
                                    • Clinical Diagnosis of Hypovolemia
                                    • Signs of Hypervolemia
                                    • Management of Hypervolemia
                                    • Fluid Management
                                    • Electrolyte physiology
                                    • Sodium physiology
                                    • Osmotic Pressure
                                    • Concentration
                                    • Hypernatremia
                                    • - Hypernatremia
                                    • Slide 67
                                    • Slide 68
                                    • Clinical Manifestations of Abnormalities in Serum Sodium
                                    • Treatment
                                    • Water deficit (L)= times TBW
                                    • The rate of fluid administration
                                    • Hyponatremia Nalt135mEqL
                                    • Slide 74
                                    • Sodium depletion
                                    • Sodium dilution
                                    • Sign and symptoms
                                    • Slide 78
                                    • Treatment
                                    • Slide 80
                                    • Slide 81
                                    • Dose
                                    • Potassium abnormalities
                                    • Hyperkalemia
                                    • Clinical manifestation of hyperkalemia
                                    • Slide 86
                                    • Slide 87
                                    • Hypokalemia
                                    • Potassium changes associated with alkalosis
                                    • Slide 90
                                    • Clinical Manifestation of Abnormalities in potassium
                                    • Slide 92
                                    • Calcium
                                    • هيپوكلسمي یونیزه Calt45 meql
                                    • علائم هیپوکلسمی
                                    • Slide 96
                                    • Slide 97
                                    • Slide 98
                                    • Slide 99
                                    • سایرعلائم
                                    • درمان
                                    • هيپركلسمي Cagt55meql
                                    • علائم
                                    • علائم قلبی
                                    • Slide 105
                                    • Magnesium Abnormalities
                                    • منیزیوم
                                    • Hypermagnesemia
                                    • Clinical manifestation hypermanesemia
                                    • Slide 110
                                    • Slide 111
                                    • Hypomagnesemia
                                    • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                    • Slide 114
                                    • Message for Today
                                    • Slide 116

                                      Colloid osmotic pressure

                                      ECF

                                      Interstitial

                                      Pla

                                      sma

                                      Capillary Membrane

                                      Capillary membrane freely permeable to water and electrolytes but not to large molecules such as proteins (albumin)

                                      The albumin on the plasma side gives rise to a colloid osmotic pressure gradient favouring movement of water into the plasma

                                      This is balanced out by the hydrostatic pressure difference

                                      H2O

                                      H2O12080

                                      H2O

                                      H2O

                                      Cell Membrane

                                      ICF

                                      Cell Membrane

                                      Interstitial

                                      H2O

                                      H2O

                                      Cell membrane is freely permeable to H20 but

                                      Cell Membrane

                                      ICF

                                      Cell Membrane

                                      Na+

                                      K+

                                      Interstitial

                                      H2O

                                      H2O

                                      Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                      Cell Membrane

                                      ICF

                                      Cell Membrane

                                      Na-

                                      K+

                                      Interstitial

                                      H2O

                                      H2O

                                      Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                      [K+] =4

                                      Cell Membrane

                                      ICF

                                      Cell Membrane

                                      Na-

                                      K+

                                      Interstitial

                                      H2O

                                      H2O

                                      Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                      [K+] =4 [K+] =150

                                      Cell Membrane

                                      ICF

                                      Cell Membrane

                                      Na-

                                      K+

                                      Interstitial

                                      H2O

                                      H2O

                                      Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                      [K+] =4 [K+] =150

                                      Na+= 144

                                      Cell Membrane

                                      ICF

                                      Cell Membrane

                                      Na-

                                      K+

                                      Interstitial

                                      H2O

                                      H2O

                                      Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                      [K+] =4 [K+] =150

                                      Na+= 144Na+= 10

                                      Composition of Fluid Compartments

                                      CATIONS ANIONS

                                      Na+ 142 Cl - 103

                                      HC03- 27

                                      504mdash

                                      3 PO4

                                      ---

                                      K+ 4 organicCa++ 5 Acid 5

                                      Mg++ 3 Protein 16

                                      CATIONS ANIONS

                                      Na+ 144 Cl - 114

                                      HC03- 30

                                      504mdash

                                      K+ 4 3 PO4

                                      ---

                                      organic

                                      Ca++ 3 Acid 5

                                      Mg++ 2 Protein 1

                                      CATIONS ANIONS

                                      K+ 150 HPO4

                                      150 504

                                      mdash

                                      HCO3- 10

                                      Mg++ 40 Protein 40

                                      Na+ 10

                                      154 mEqL 153 mEqL 153 mEqL154 mEqL

                                      PLASMA INTERSTITAL FLID

                                      200 mEqL 200 mEqL

                                      INTRACELLULAR FLID

                                      Composition of Body FluidsComposition of Body Fluids

                                      Ca 2+

                                      Mg 2+

                                      K+

                                      Na+

                                      Cl-

                                      PO43-

                                      Organic anion

                                      HCO3-

                                      Protein

                                      0

                                      50

                                      50

                                      100

                                      150

                                      100

                                      150

                                      Cations Anions

                                      EC

                                      FICF

                                      Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                                      والکترولیت آب تغییرات روی موثر عوامل

                                      1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                                      عمل 2 از قبل والکترولیت آب وضعیت

                                      اندوکرینوپاتی )3 همراه )بیماریهای

                                      4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                                      Reasons for fluid therapyReasons for fluid therapy

                                      Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                                      bull Correct hypovolaemiaCorrect hypovolaemia

                                      bull Maintain cardiac outputMaintain cardiac output

                                      bull Optimise gas exchangeOptimise gas exchange

                                      bull Replace electrolytes amp waterReplace electrolytes amp water

                                      bull Maintain urine outputMaintain urine output

                                      Colloids + RBCs

                                      Crystalloids

                                      Identify what is the goal

                                      Choose fluid which best achieves the goal

                                      عروقی داخل مایع حجم ارزیابی

                                      بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                                      وریدی محلولهای

                                      Fluids bull Crystalloids

                                      bull Colloids

                                      bull blood

                                      Which of the following solutions is isotonic

                                      A D5W

                                      B 045 saline

                                      C 09 saline

                                      D D5 in 09 saline

                                      SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                                      ECFECF 142 4 5 103 27 280-310

                                      Lactated Lactated RingerrsquosRingerrsquos

                                      130 4 3 109 28 273

                                      09 NaCl09 NaCl 154 154 308

                                      045 045 NaClNaCl

                                      77 77 154

                                      D5WD5W

                                      D5045 D5045 NaClNaCl

                                      77 77 50 406

                                      3 NaCl3 NaCl 513 513 1026

                                      6 6 HetastarchHetastarch

                                      500 154 154 310

                                      5 5 AlbuminAlbumin

                                      250500130-160

                                      lt25130-160

                                      330

                                      25 25 AlbuminAlbumin

                                      2050100130-160

                                      lt25130-160

                                      330

                                      Common parenteral fluid therapyCommon parenteral fluid therapy

                                      CrystalloidsCrystalloids

                                      bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                      Colloid SolutionsColloid Solutions

                                      bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                      - Haes-steril 10

                                      الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                      کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                      ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                      osm=273

                                      09Nacl

                                      bull Na=154

                                      bull CL= 154

                                      کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                      PH=56است

                                      Postoperative (maintenance)

                                      045Nacl +5 dextrose +KCL

                                      Perioperative management of fluid balance include

                                      1 Preoperative evaluation

                                      2 Intraoperative maintenance

                                      3 Replacement of fluid losses

                                      Preexisting fluid deficits

                                      bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                      bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                      Maintenance requirements

                                      bull Up to 10 kg = 4cckghr

                                      bull 11-20kg = add 2cckghr

                                      bull 21kg and above = add 1cckghr

                                      bull Insensible losses = 2cckghr

                                      Surgical fluid losses

                                      Blood loss (measurement)

                                      1 Suction container

                                      2 Surgical sponge

                                      3 Hct and tachycardia not specific

                                      4 ABG and UO if hypoperfusion occur

                                      5 Blood loss=31 with crystalloid

                                      Other losses (third space loss)

                                      Third space loss

                                      1 Minimal (herniorrapy) =2-4cckghr

                                      2 Moderate (cholecystectomy)=4-6cckghr

                                      3 Severe (bowel resection) = 6-8cckghr

                                      Crystalloid solution

                                      1 The main solutions is either glucose or saline

                                      2 Hypotonic or isotonic or hypertonic

                                      3 Safe nontoxic reaction free inexpensive

                                      4 Complication is edema if large volumes are needed

                                      5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                      Colloids

                                      1 Albumin

                                      2 Hydroxyethyl starch

                                      3 Dextran

                                      Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                      factor )These colloid is best avoided in patients with

                                      coagulopaty

                                      The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                      1000cc

                                      500cc

                                      500cc

                                      500cc

                                      200

                                      600

                                      1000

                                      Lactated Ringers

                                      5 Albumin

                                      6 Hetastarch

                                      Whole blood

                                      Blood volumeInfusion volume

                                      Colloid versus crystalloid solutions

                                      Transfusion consideration

                                      bull HB lt7 mg dl increase CO

                                      bull Ideal Hb is 7-8 mgdl

                                      bull In IHD patients or pulmonary disease gt 10 mgdl

                                      بدن مایعات حجم در اختالل

                                      1 Fluid volume deficit

                                      2 Fluid volume excess

                                      Fluid volume deficit(FVD)

                                      ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                      کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                      ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                      باشد آن با همراه دیگری اختالل مگر

                                      DEHYDRATION

                                      سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                      سلولی خارج حجم کاهش علل

                                      1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                      2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                      کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                      Signs of HypovolemiaSigns of Hypovolemia

                                      bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                      Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                      bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                      Signs of HypervolemiaSigns of Hypervolemia

                                      bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                      Especially when hypo-albuminemia

                                      Management of Management of HypervolemiaHypervolemia

                                      bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                      Fluid ManagementFluid Management

                                      bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                      Electrolyte physiology

                                      Sodium physiology

                                      Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                      Normal amount 135-145 meql

                                      Osmotic Pressure

                                      Calculated serum osmolality =

                                      2 sodium+ glucose18 + BUN 28

                                      Osmolality = 290 mosm

                                      Concentration

                                      1Serum sodium concentration2Serum osmolarity

                                      bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                      drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                      DW5)

                                      Hypernatremia

                                      Serum Nagt145mEqL

                                      - Hypernatremia

                                      Loss of Free Water

                                      Gain of sodium in excess of water

                                      Hypernatremia

                                      -Hypernatremia Hypo volemic

                                      Hyper volemic

                                      Normo volemic

                                      Hypernatremia

                                      Volume Status

                                      Normal

                                      Nonrenal water loss

                                      Skin

                                      Gastrointestinal

                                      Renal water loss

                                      Renal disease

                                      Diuretics

                                      Diabetes insipidus

                                      High

                                      Iatrogenic sodium administration

                                      Mineralocorticoid excess

                                      Aldosteronism

                                      Cushingrsquos disease

                                      Congenital adrenal

                                      hyperplasia

                                      Low

                                      Nonrenal water loss

                                      Skin

                                      Gastrointestinal losses

                                      Renal water losses

                                      Renal (tubular) Diuretics

                                      Osmotic diuretics

                                      Diabetes insipidus

                                      Adrenal failure

                                      Asymptomatic

                                      Hypernatremia Symptomatic (Nagt160 meqL)

                                      Clinical Manifestations of Abnormalities in Serum Sodium

                                      Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                      Body system hypernatremia

                                      Treatment

                                      Normal saline in hypovolemic patients

                                      Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                      saline or entral water)

                                      Water deficit (L)= times TBW

                                      The formula used to estimate the amount of water required to correct hypernatremia

                                      Estimate TBW as 55 of lean body mass in men and 45 in women

                                      Serum sodium-140

                                      140

                                      The rate of fluid administration

                                      1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                      2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                      Hyponatremia Nalt135mEqL

                                      Causes

                                      1 Sodium depletion

                                      2 Sodium dilution

                                      bull Incidence = 45

                                      bull After surgery=1

                                      bull Mortality = 2 times normal

                                      Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                      volume deficit

                                      Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                      Sign and symptoms

                                      bull CNS symptom when Nalt123 meql

                                      bull Cardiac symptom when Nalt100 meql

                                      For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                      Body System Hyponatremia

                                      central nervous system Headache confusion hyper-or hypoactive deep tendon

                                      reflexes seizures coma increased intracranial pressure

                                      Musculoskeletal Weakness fatigue muscle crampstwitching

                                      Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                      Cardiovascular Hypertension and bradycardia if significant increases in

                                      intracranial pressure

                                      Tissue Lacrimation salivation

                                      Renal Oliguria

                                      Clinical Manifestations of Abnormalities in Serum Sodium

                                      Treatment

                                      1=Depend on ECF

                                      2=CNS sign

                                      Treatment

                                      1 Asymptomatic increase the sodium level by no more than

                                      05-1 meqLh to a maximum increase of 12 meqL per day

                                      2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                      more than 1meqL per hour until the serum Na level reaches 130

                                      meqL or neurologic symptoms are improved

                                      Rapid correction of hyponatremia

                                      Pontine myelinolysis

                                      Seizures weaknessparesis akinetic

                                      movements unresponsiveness

                                      Permanent brain damage

                                      Death

                                      Dose

                                      Na deficit meq =(140- Na meql) TBW

                                      باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                      شود اصالح آهسته سپس

                                      Potassium abnormalities

                                      bull The average dietary intake of potassium 50-100meqd

                                      bull The average renal excretion of potassium 10-700 meqd

                                      - 2 of the total body potassium in ECF (45meqL)

                                      - Factors that influence serum potassium

                                      1 Surgical stress

                                      2 Injury

                                      3 Acidosis

                                      4 Tissue catabolism

                                      Hyperkalemia

                                      The normal range of serum potassium 35-5 meqL

                                      Etiology of Hyperkalemia

                                      Increased intake Potassium supplementation

                                      Blood transfusions

                                      Endogenous loaddestruction

                                      hemolysis rhabdomyolysis

                                      cruch injury gastrointestinal hemorrhage

                                      Increased release Acidosis

                                      Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                      Renal insufficiencyfailure

                                      Clinical manifestation of hyperkalemia

                                      System hyperkalemia

                                      Gastrointestinal Nauseavomiting colic diarrhea

                                      Neuromuscular weakness paralysis respiratory failure

                                      Cardiovascular Arrhythmia arrest

                                      ECG changes Peaked T waves (early change)

                                      Flattened P wave

                                      Prolonged PR interval (first-degree block)

                                      Widened QRS complex

                                      Sine wave formation

                                      Ventricular fibrillation

                                      Treatment

                                      Treatment of symptomatic hyperkalemia

                                      Potassium removal Kayexalate

                                      Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                      Rectal administration is 50 g in 200 mL 20 sorbitol

                                      Dialysis

                                      Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                      Bicarbonate 1 vial intravenous

                                      Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                      HypokalemiaEtiology

                                      inadequate intake

                                      Dietary potassium-free intravenous fluids potassium-deficient

                                      total parenteral nutrition

                                      Excessive potassium excretion

                                      Hyperaldosteronism

                                      Medications

                                      Gastrointestinal losses

                                      Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                      Renal loss of potassium (gastric fluid either as vomiting or high

                                      nasogastric output)

                                      Intracellular-shift (metabolic alkalosis or insulin therapy)

                                      Potassium changes associated with alkalosis

                                      Potassium decrease by 03 meqL for every 01

                                      increase in PH above normal

                                      Magnesium Depletion

                                      (drug induced amphotericin amioglycosides cisplatin)

                                      Renal potassium wastage

                                      Hypokalemia

                                      Magnesium Depletion

                                      (drug induced amphotericin amioglycosides cisplatin)

                                      Renal potassium wastage

                                      Hypokalemia

                                      Clinical Manifestation of Abnormalities in potassium

                                      System hypokalemia

                                      Gastrointestinal Ileus constipation

                                      Neuromuscular Decreased reflexes fatigue weakness

                                      paralysis

                                      Cardiovascular Arrest

                                      ECG changes U-waves

                                      T-wave flattening

                                      ST-segment changes

                                      Arrhythmias

                                      Treatment

                                      Potassium

                                      Serum potassium level lt40 mEqL

                                      Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                      times 1 doses

                                      Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                      Symptomatic KC1 20 mEq IV q1h times 4 doses

                                      Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                      asymptomatic replace as per above protocol

                                      Electrolyte Replacement Therapy Protocol

                                      bull Oral repletion for mild and asymptomatic hypokalemia

                                      bull IV repletion for severe and symptomatic hypokalemia

                                      Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                      ( دندانها( ndash استخوانbull كلسيم نقش

                                      عصبي 1 ايمپالسهاي )NMJ(انتقال

                                      صاف 2 عضالت انقباض

                                      هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                      انعقاد 4

                                      یونیزه Calt45 meql هيپوكلسمي

                                      عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                      ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                      میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                      ( شود می پیوند شده

                                      هیپوکلسمی عالئم

                                      رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                      سایرعالئم

                                      قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                      درمان

                                      ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                      Cagt55meql هيپركلسمي

                                      هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                      عالئم

                                      bullGI

                                      bullCardiovascular bullRenal (polyuria)

                                      bullCNS

                                      قلبی عالئم

                                      bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                      QRS شدن )Q-Tوكوتاه

                                      درمان

                                      ایزوتونیک 1 نمکی محلول انفوزیون

                                      الزیکس2

                                      تونین 3 کلسی

                                      کورتون4

                                      دیالیز5

                                      Magnesium Abnormalities

                                      Normal dietary intake 20meq (240mg)

                                      Excretion in both the feces and urine

                                      Normal serum level 19-25 mgdL

                                      منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                      تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                      bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                      Hypermagnesemia

                                      Etiology

                                      1 Impaired renal function

                                      2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                      Clinical manifestation hypermanesemia

                                      System hypermanesemia

                                      Gastrointestinal Nauseavomiting

                                      Neuromuscular weakness lethargy Decreased

                                      reflexes

                                      Cardiovascular Hypotension arrest

                                      ECG changes Increased PR interval

                                      Widened QRS complex

                                      Elevated T waves

                                      Treatment

                                      1 Withhold exogenous sources of magnesium

                                      2 Correct volume deficit

                                      3 Correct acidosis if present

                                      4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                      5 Dialysis (if elevated levels or symptoms persist)

                                      عالئم

                                      bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                      meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                      meqL

                                      Hypomagnesemia

                                      Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                      homeostasis

                                      Etiology

                                      1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                      inadequate supplementation of magnesium)

                                      2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                      3 GI losses (diarrhea)

                                      4 Malabsorption

                                      5 Acute pancreatitis

                                      6 Diabetic ketoacidosis

                                      7 Primary aldosteronism

                                      Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                      1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                      2 Delirium and seizures in severe deficiency

                                      3 ECG changes Prolonged QT and PR interval

                                      ST-segment depression

                                      Flattening or inversion of P waves

                                      Torsades de pointes

                                      Arrhythmia

                                      Treatment

                                      1 For asymptomatic and mild hypomagnesemia administer oral mg

                                      2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                      Message for Today

                                      ICF

                                      Interstitial

                                      Pla

                                      sma

                                      5 Dex

                                      bull Do not reccussitate sick patients with any Dextrose solution

                                      • Fluid and Electrolyte Management of the Surgical Patient
                                      • Slide 2
                                      • Slide 3
                                      • Slide 4
                                      • Total Body Water
                                      • Body Fluid Compartments
                                      • Total body water (TBW)
                                      • Body compartment fluid
                                      • Example men with 70kg
                                      • Fluid compartments
                                      • Slide 11
                                      • Slide 12
                                      • Slide 13
                                      • Slide 14
                                      • Slide 15
                                      • Colloid osmotic pressure
                                      • Slide 17
                                      • Slide 18
                                      • Slide 19
                                      • Cell Membrane
                                      • Slide 21
                                      • Slide 22
                                      • Slide 23
                                      • Slide 24
                                      • Slide 25
                                      • Composition of Fluid Compartments
                                      • Composition of Body Fluids
                                      • عوامل موثر روی تغییرات آب والکترولیت
                                      • Reasons for fluid therapy
                                      • ارزیابی حجم مایع داخل عروقی
                                      • محلولهای وریدی
                                      • Fluids
                                      • Slide 33
                                      • Slide 34
                                      • Slide 35
                                      • Crystalloids
                                      • Colloid Solutions
                                      • رینگر لاکتات
                                      • 09Nacl
                                      • Postoperative (maintenance)
                                      • Slide 41
                                      • Preexisting fluid deficits
                                      • Maintenance requirements
                                      • Surgical fluid losses
                                      • Third space loss
                                      • Crystalloid solution
                                      • Colloids
                                      • Complications
                                      • The Influence of Colloid amp Crystalloid on Blood Volume
                                      • Colloid versus crystalloid solutions
                                      • Transfusion consideration
                                      • اختلال در حجم مایعات بدن
                                      • Fluid volume deficit (FVD)
                                      • DEHYDRATION
                                      • علل کاهش حجم خارج سلولی
                                      • Signs of Hypovolemia
                                      • Clinical Diagnosis of Hypovolemia
                                      • Signs of Hypervolemia
                                      • Management of Hypervolemia
                                      • Fluid Management
                                      • Electrolyte physiology
                                      • Sodium physiology
                                      • Osmotic Pressure
                                      • Concentration
                                      • Hypernatremia
                                      • - Hypernatremia
                                      • Slide 67
                                      • Slide 68
                                      • Clinical Manifestations of Abnormalities in Serum Sodium
                                      • Treatment
                                      • Water deficit (L)= times TBW
                                      • The rate of fluid administration
                                      • Hyponatremia Nalt135mEqL
                                      • Slide 74
                                      • Sodium depletion
                                      • Sodium dilution
                                      • Sign and symptoms
                                      • Slide 78
                                      • Treatment
                                      • Slide 80
                                      • Slide 81
                                      • Dose
                                      • Potassium abnormalities
                                      • Hyperkalemia
                                      • Clinical manifestation of hyperkalemia
                                      • Slide 86
                                      • Slide 87
                                      • Hypokalemia
                                      • Potassium changes associated with alkalosis
                                      • Slide 90
                                      • Clinical Manifestation of Abnormalities in potassium
                                      • Slide 92
                                      • Calcium
                                      • هيپوكلسمي یونیزه Calt45 meql
                                      • علائم هیپوکلسمی
                                      • Slide 96
                                      • Slide 97
                                      • Slide 98
                                      • Slide 99
                                      • سایرعلائم
                                      • درمان
                                      • هيپركلسمي Cagt55meql
                                      • علائم
                                      • علائم قلبی
                                      • Slide 105
                                      • Magnesium Abnormalities
                                      • منیزیوم
                                      • Hypermagnesemia
                                      • Clinical manifestation hypermanesemia
                                      • Slide 110
                                      • Slide 111
                                      • Hypomagnesemia
                                      • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                      • Slide 114
                                      • Message for Today
                                      • Slide 116

                                        Cell Membrane

                                        ICF

                                        Cell Membrane

                                        Interstitial

                                        H2O

                                        H2O

                                        Cell membrane is freely permeable to H20 but

                                        Cell Membrane

                                        ICF

                                        Cell Membrane

                                        Na+

                                        K+

                                        Interstitial

                                        H2O

                                        H2O

                                        Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                        Cell Membrane

                                        ICF

                                        Cell Membrane

                                        Na-

                                        K+

                                        Interstitial

                                        H2O

                                        H2O

                                        Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                        [K+] =4

                                        Cell Membrane

                                        ICF

                                        Cell Membrane

                                        Na-

                                        K+

                                        Interstitial

                                        H2O

                                        H2O

                                        Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                        [K+] =4 [K+] =150

                                        Cell Membrane

                                        ICF

                                        Cell Membrane

                                        Na-

                                        K+

                                        Interstitial

                                        H2O

                                        H2O

                                        Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                        [K+] =4 [K+] =150

                                        Na+= 144

                                        Cell Membrane

                                        ICF

                                        Cell Membrane

                                        Na-

                                        K+

                                        Interstitial

                                        H2O

                                        H2O

                                        Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                        [K+] =4 [K+] =150

                                        Na+= 144Na+= 10

                                        Composition of Fluid Compartments

                                        CATIONS ANIONS

                                        Na+ 142 Cl - 103

                                        HC03- 27

                                        504mdash

                                        3 PO4

                                        ---

                                        K+ 4 organicCa++ 5 Acid 5

                                        Mg++ 3 Protein 16

                                        CATIONS ANIONS

                                        Na+ 144 Cl - 114

                                        HC03- 30

                                        504mdash

                                        K+ 4 3 PO4

                                        ---

                                        organic

                                        Ca++ 3 Acid 5

                                        Mg++ 2 Protein 1

                                        CATIONS ANIONS

                                        K+ 150 HPO4

                                        150 504

                                        mdash

                                        HCO3- 10

                                        Mg++ 40 Protein 40

                                        Na+ 10

                                        154 mEqL 153 mEqL 153 mEqL154 mEqL

                                        PLASMA INTERSTITAL FLID

                                        200 mEqL 200 mEqL

                                        INTRACELLULAR FLID

                                        Composition of Body FluidsComposition of Body Fluids

                                        Ca 2+

                                        Mg 2+

                                        K+

                                        Na+

                                        Cl-

                                        PO43-

                                        Organic anion

                                        HCO3-

                                        Protein

                                        0

                                        50

                                        50

                                        100

                                        150

                                        100

                                        150

                                        Cations Anions

                                        EC

                                        FICF

                                        Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                                        والکترولیت آب تغییرات روی موثر عوامل

                                        1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                                        عمل 2 از قبل والکترولیت آب وضعیت

                                        اندوکرینوپاتی )3 همراه )بیماریهای

                                        4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                                        Reasons for fluid therapyReasons for fluid therapy

                                        Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                                        bull Correct hypovolaemiaCorrect hypovolaemia

                                        bull Maintain cardiac outputMaintain cardiac output

                                        bull Optimise gas exchangeOptimise gas exchange

                                        bull Replace electrolytes amp waterReplace electrolytes amp water

                                        bull Maintain urine outputMaintain urine output

                                        Colloids + RBCs

                                        Crystalloids

                                        Identify what is the goal

                                        Choose fluid which best achieves the goal

                                        عروقی داخل مایع حجم ارزیابی

                                        بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                                        وریدی محلولهای

                                        Fluids bull Crystalloids

                                        bull Colloids

                                        bull blood

                                        Which of the following solutions is isotonic

                                        A D5W

                                        B 045 saline

                                        C 09 saline

                                        D D5 in 09 saline

                                        SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                                        ECFECF 142 4 5 103 27 280-310

                                        Lactated Lactated RingerrsquosRingerrsquos

                                        130 4 3 109 28 273

                                        09 NaCl09 NaCl 154 154 308

                                        045 045 NaClNaCl

                                        77 77 154

                                        D5WD5W

                                        D5045 D5045 NaClNaCl

                                        77 77 50 406

                                        3 NaCl3 NaCl 513 513 1026

                                        6 6 HetastarchHetastarch

                                        500 154 154 310

                                        5 5 AlbuminAlbumin

                                        250500130-160

                                        lt25130-160

                                        330

                                        25 25 AlbuminAlbumin

                                        2050100130-160

                                        lt25130-160

                                        330

                                        Common parenteral fluid therapyCommon parenteral fluid therapy

                                        CrystalloidsCrystalloids

                                        bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                        Colloid SolutionsColloid Solutions

                                        bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                        - Haes-steril 10

                                        الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                        کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                        ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                        osm=273

                                        09Nacl

                                        bull Na=154

                                        bull CL= 154

                                        کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                        PH=56است

                                        Postoperative (maintenance)

                                        045Nacl +5 dextrose +KCL

                                        Perioperative management of fluid balance include

                                        1 Preoperative evaluation

                                        2 Intraoperative maintenance

                                        3 Replacement of fluid losses

                                        Preexisting fluid deficits

                                        bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                        bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                        Maintenance requirements

                                        bull Up to 10 kg = 4cckghr

                                        bull 11-20kg = add 2cckghr

                                        bull 21kg and above = add 1cckghr

                                        bull Insensible losses = 2cckghr

                                        Surgical fluid losses

                                        Blood loss (measurement)

                                        1 Suction container

                                        2 Surgical sponge

                                        3 Hct and tachycardia not specific

                                        4 ABG and UO if hypoperfusion occur

                                        5 Blood loss=31 with crystalloid

                                        Other losses (third space loss)

                                        Third space loss

                                        1 Minimal (herniorrapy) =2-4cckghr

                                        2 Moderate (cholecystectomy)=4-6cckghr

                                        3 Severe (bowel resection) = 6-8cckghr

                                        Crystalloid solution

                                        1 The main solutions is either glucose or saline

                                        2 Hypotonic or isotonic or hypertonic

                                        3 Safe nontoxic reaction free inexpensive

                                        4 Complication is edema if large volumes are needed

                                        5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                        Colloids

                                        1 Albumin

                                        2 Hydroxyethyl starch

                                        3 Dextran

                                        Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                        factor )These colloid is best avoided in patients with

                                        coagulopaty

                                        The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                        1000cc

                                        500cc

                                        500cc

                                        500cc

                                        200

                                        600

                                        1000

                                        Lactated Ringers

                                        5 Albumin

                                        6 Hetastarch

                                        Whole blood

                                        Blood volumeInfusion volume

                                        Colloid versus crystalloid solutions

                                        Transfusion consideration

                                        bull HB lt7 mg dl increase CO

                                        bull Ideal Hb is 7-8 mgdl

                                        bull In IHD patients or pulmonary disease gt 10 mgdl

                                        بدن مایعات حجم در اختالل

                                        1 Fluid volume deficit

                                        2 Fluid volume excess

                                        Fluid volume deficit(FVD)

                                        ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                        کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                        ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                        باشد آن با همراه دیگری اختالل مگر

                                        DEHYDRATION

                                        سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                        سلولی خارج حجم کاهش علل

                                        1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                        2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                        کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                        Signs of HypovolemiaSigns of Hypovolemia

                                        bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                        Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                        bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                        Signs of HypervolemiaSigns of Hypervolemia

                                        bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                        Especially when hypo-albuminemia

                                        Management of Management of HypervolemiaHypervolemia

                                        bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                        Fluid ManagementFluid Management

                                        bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                        Electrolyte physiology

                                        Sodium physiology

                                        Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                        Normal amount 135-145 meql

                                        Osmotic Pressure

                                        Calculated serum osmolality =

                                        2 sodium+ glucose18 + BUN 28

                                        Osmolality = 290 mosm

                                        Concentration

                                        1Serum sodium concentration2Serum osmolarity

                                        bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                        drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                        DW5)

                                        Hypernatremia

                                        Serum Nagt145mEqL

                                        - Hypernatremia

                                        Loss of Free Water

                                        Gain of sodium in excess of water

                                        Hypernatremia

                                        -Hypernatremia Hypo volemic

                                        Hyper volemic

                                        Normo volemic

                                        Hypernatremia

                                        Volume Status

                                        Normal

                                        Nonrenal water loss

                                        Skin

                                        Gastrointestinal

                                        Renal water loss

                                        Renal disease

                                        Diuretics

                                        Diabetes insipidus

                                        High

                                        Iatrogenic sodium administration

                                        Mineralocorticoid excess

                                        Aldosteronism

                                        Cushingrsquos disease

                                        Congenital adrenal

                                        hyperplasia

                                        Low

                                        Nonrenal water loss

                                        Skin

                                        Gastrointestinal losses

                                        Renal water losses

                                        Renal (tubular) Diuretics

                                        Osmotic diuretics

                                        Diabetes insipidus

                                        Adrenal failure

                                        Asymptomatic

                                        Hypernatremia Symptomatic (Nagt160 meqL)

                                        Clinical Manifestations of Abnormalities in Serum Sodium

                                        Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                        Body system hypernatremia

                                        Treatment

                                        Normal saline in hypovolemic patients

                                        Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                        saline or entral water)

                                        Water deficit (L)= times TBW

                                        The formula used to estimate the amount of water required to correct hypernatremia

                                        Estimate TBW as 55 of lean body mass in men and 45 in women

                                        Serum sodium-140

                                        140

                                        The rate of fluid administration

                                        1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                        2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                        Hyponatremia Nalt135mEqL

                                        Causes

                                        1 Sodium depletion

                                        2 Sodium dilution

                                        bull Incidence = 45

                                        bull After surgery=1

                                        bull Mortality = 2 times normal

                                        Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                        volume deficit

                                        Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                        Sign and symptoms

                                        bull CNS symptom when Nalt123 meql

                                        bull Cardiac symptom when Nalt100 meql

                                        For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                        Body System Hyponatremia

                                        central nervous system Headache confusion hyper-or hypoactive deep tendon

                                        reflexes seizures coma increased intracranial pressure

                                        Musculoskeletal Weakness fatigue muscle crampstwitching

                                        Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                        Cardiovascular Hypertension and bradycardia if significant increases in

                                        intracranial pressure

                                        Tissue Lacrimation salivation

                                        Renal Oliguria

                                        Clinical Manifestations of Abnormalities in Serum Sodium

                                        Treatment

                                        1=Depend on ECF

                                        2=CNS sign

                                        Treatment

                                        1 Asymptomatic increase the sodium level by no more than

                                        05-1 meqLh to a maximum increase of 12 meqL per day

                                        2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                        more than 1meqL per hour until the serum Na level reaches 130

                                        meqL or neurologic symptoms are improved

                                        Rapid correction of hyponatremia

                                        Pontine myelinolysis

                                        Seizures weaknessparesis akinetic

                                        movements unresponsiveness

                                        Permanent brain damage

                                        Death

                                        Dose

                                        Na deficit meq =(140- Na meql) TBW

                                        باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                        شود اصالح آهسته سپس

                                        Potassium abnormalities

                                        bull The average dietary intake of potassium 50-100meqd

                                        bull The average renal excretion of potassium 10-700 meqd

                                        - 2 of the total body potassium in ECF (45meqL)

                                        - Factors that influence serum potassium

                                        1 Surgical stress

                                        2 Injury

                                        3 Acidosis

                                        4 Tissue catabolism

                                        Hyperkalemia

                                        The normal range of serum potassium 35-5 meqL

                                        Etiology of Hyperkalemia

                                        Increased intake Potassium supplementation

                                        Blood transfusions

                                        Endogenous loaddestruction

                                        hemolysis rhabdomyolysis

                                        cruch injury gastrointestinal hemorrhage

                                        Increased release Acidosis

                                        Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                        Renal insufficiencyfailure

                                        Clinical manifestation of hyperkalemia

                                        System hyperkalemia

                                        Gastrointestinal Nauseavomiting colic diarrhea

                                        Neuromuscular weakness paralysis respiratory failure

                                        Cardiovascular Arrhythmia arrest

                                        ECG changes Peaked T waves (early change)

                                        Flattened P wave

                                        Prolonged PR interval (first-degree block)

                                        Widened QRS complex

                                        Sine wave formation

                                        Ventricular fibrillation

                                        Treatment

                                        Treatment of symptomatic hyperkalemia

                                        Potassium removal Kayexalate

                                        Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                        Rectal administration is 50 g in 200 mL 20 sorbitol

                                        Dialysis

                                        Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                        Bicarbonate 1 vial intravenous

                                        Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                        HypokalemiaEtiology

                                        inadequate intake

                                        Dietary potassium-free intravenous fluids potassium-deficient

                                        total parenteral nutrition

                                        Excessive potassium excretion

                                        Hyperaldosteronism

                                        Medications

                                        Gastrointestinal losses

                                        Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                        Renal loss of potassium (gastric fluid either as vomiting or high

                                        nasogastric output)

                                        Intracellular-shift (metabolic alkalosis or insulin therapy)

                                        Potassium changes associated with alkalosis

                                        Potassium decrease by 03 meqL for every 01

                                        increase in PH above normal

                                        Magnesium Depletion

                                        (drug induced amphotericin amioglycosides cisplatin)

                                        Renal potassium wastage

                                        Hypokalemia

                                        Magnesium Depletion

                                        (drug induced amphotericin amioglycosides cisplatin)

                                        Renal potassium wastage

                                        Hypokalemia

                                        Clinical Manifestation of Abnormalities in potassium

                                        System hypokalemia

                                        Gastrointestinal Ileus constipation

                                        Neuromuscular Decreased reflexes fatigue weakness

                                        paralysis

                                        Cardiovascular Arrest

                                        ECG changes U-waves

                                        T-wave flattening

                                        ST-segment changes

                                        Arrhythmias

                                        Treatment

                                        Potassium

                                        Serum potassium level lt40 mEqL

                                        Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                        times 1 doses

                                        Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                        Symptomatic KC1 20 mEq IV q1h times 4 doses

                                        Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                        asymptomatic replace as per above protocol

                                        Electrolyte Replacement Therapy Protocol

                                        bull Oral repletion for mild and asymptomatic hypokalemia

                                        bull IV repletion for severe and symptomatic hypokalemia

                                        Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                        ( دندانها( ndash استخوانbull كلسيم نقش

                                        عصبي 1 ايمپالسهاي )NMJ(انتقال

                                        صاف 2 عضالت انقباض

                                        هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                        انعقاد 4

                                        یونیزه Calt45 meql هيپوكلسمي

                                        عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                        ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                        میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                        ( شود می پیوند شده

                                        هیپوکلسمی عالئم

                                        رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                        سایرعالئم

                                        قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                        درمان

                                        ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                        Cagt55meql هيپركلسمي

                                        هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                        عالئم

                                        bullGI

                                        bullCardiovascular bullRenal (polyuria)

                                        bullCNS

                                        قلبی عالئم

                                        bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                        QRS شدن )Q-Tوكوتاه

                                        درمان

                                        ایزوتونیک 1 نمکی محلول انفوزیون

                                        الزیکس2

                                        تونین 3 کلسی

                                        کورتون4

                                        دیالیز5

                                        Magnesium Abnormalities

                                        Normal dietary intake 20meq (240mg)

                                        Excretion in both the feces and urine

                                        Normal serum level 19-25 mgdL

                                        منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                        تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                        bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                        Hypermagnesemia

                                        Etiology

                                        1 Impaired renal function

                                        2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                        Clinical manifestation hypermanesemia

                                        System hypermanesemia

                                        Gastrointestinal Nauseavomiting

                                        Neuromuscular weakness lethargy Decreased

                                        reflexes

                                        Cardiovascular Hypotension arrest

                                        ECG changes Increased PR interval

                                        Widened QRS complex

                                        Elevated T waves

                                        Treatment

                                        1 Withhold exogenous sources of magnesium

                                        2 Correct volume deficit

                                        3 Correct acidosis if present

                                        4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                        5 Dialysis (if elevated levels or symptoms persist)

                                        عالئم

                                        bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                        meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                        meqL

                                        Hypomagnesemia

                                        Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                        homeostasis

                                        Etiology

                                        1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                        inadequate supplementation of magnesium)

                                        2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                        3 GI losses (diarrhea)

                                        4 Malabsorption

                                        5 Acute pancreatitis

                                        6 Diabetic ketoacidosis

                                        7 Primary aldosteronism

                                        Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                        1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                        2 Delirium and seizures in severe deficiency

                                        3 ECG changes Prolonged QT and PR interval

                                        ST-segment depression

                                        Flattening or inversion of P waves

                                        Torsades de pointes

                                        Arrhythmia

                                        Treatment

                                        1 For asymptomatic and mild hypomagnesemia administer oral mg

                                        2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                        Message for Today

                                        ICF

                                        Interstitial

                                        Pla

                                        sma

                                        5 Dex

                                        bull Do not reccussitate sick patients with any Dextrose solution

                                        • Fluid and Electrolyte Management of the Surgical Patient
                                        • Slide 2
                                        • Slide 3
                                        • Slide 4
                                        • Total Body Water
                                        • Body Fluid Compartments
                                        • Total body water (TBW)
                                        • Body compartment fluid
                                        • Example men with 70kg
                                        • Fluid compartments
                                        • Slide 11
                                        • Slide 12
                                        • Slide 13
                                        • Slide 14
                                        • Slide 15
                                        • Colloid osmotic pressure
                                        • Slide 17
                                        • Slide 18
                                        • Slide 19
                                        • Cell Membrane
                                        • Slide 21
                                        • Slide 22
                                        • Slide 23
                                        • Slide 24
                                        • Slide 25
                                        • Composition of Fluid Compartments
                                        • Composition of Body Fluids
                                        • عوامل موثر روی تغییرات آب والکترولیت
                                        • Reasons for fluid therapy
                                        • ارزیابی حجم مایع داخل عروقی
                                        • محلولهای وریدی
                                        • Fluids
                                        • Slide 33
                                        • Slide 34
                                        • Slide 35
                                        • Crystalloids
                                        • Colloid Solutions
                                        • رینگر لاکتات
                                        • 09Nacl
                                        • Postoperative (maintenance)
                                        • Slide 41
                                        • Preexisting fluid deficits
                                        • Maintenance requirements
                                        • Surgical fluid losses
                                        • Third space loss
                                        • Crystalloid solution
                                        • Colloids
                                        • Complications
                                        • The Influence of Colloid amp Crystalloid on Blood Volume
                                        • Colloid versus crystalloid solutions
                                        • Transfusion consideration
                                        • اختلال در حجم مایعات بدن
                                        • Fluid volume deficit (FVD)
                                        • DEHYDRATION
                                        • علل کاهش حجم خارج سلولی
                                        • Signs of Hypovolemia
                                        • Clinical Diagnosis of Hypovolemia
                                        • Signs of Hypervolemia
                                        • Management of Hypervolemia
                                        • Fluid Management
                                        • Electrolyte physiology
                                        • Sodium physiology
                                        • Osmotic Pressure
                                        • Concentration
                                        • Hypernatremia
                                        • - Hypernatremia
                                        • Slide 67
                                        • Slide 68
                                        • Clinical Manifestations of Abnormalities in Serum Sodium
                                        • Treatment
                                        • Water deficit (L)= times TBW
                                        • The rate of fluid administration
                                        • Hyponatremia Nalt135mEqL
                                        • Slide 74
                                        • Sodium depletion
                                        • Sodium dilution
                                        • Sign and symptoms
                                        • Slide 78
                                        • Treatment
                                        • Slide 80
                                        • Slide 81
                                        • Dose
                                        • Potassium abnormalities
                                        • Hyperkalemia
                                        • Clinical manifestation of hyperkalemia
                                        • Slide 86
                                        • Slide 87
                                        • Hypokalemia
                                        • Potassium changes associated with alkalosis
                                        • Slide 90
                                        • Clinical Manifestation of Abnormalities in potassium
                                        • Slide 92
                                        • Calcium
                                        • هيپوكلسمي یونیزه Calt45 meql
                                        • علائم هیپوکلسمی
                                        • Slide 96
                                        • Slide 97
                                        • Slide 98
                                        • Slide 99
                                        • سایرعلائم
                                        • درمان
                                        • هيپركلسمي Cagt55meql
                                        • علائم
                                        • علائم قلبی
                                        • Slide 105
                                        • Magnesium Abnormalities
                                        • منیزیوم
                                        • Hypermagnesemia
                                        • Clinical manifestation hypermanesemia
                                        • Slide 110
                                        • Slide 111
                                        • Hypomagnesemia
                                        • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                        • Slide 114
                                        • Message for Today
                                        • Slide 116

                                          Cell Membrane

                                          ICF

                                          Cell Membrane

                                          Na+

                                          K+

                                          Interstitial

                                          H2O

                                          H2O

                                          Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                          Cell Membrane

                                          ICF

                                          Cell Membrane

                                          Na-

                                          K+

                                          Interstitial

                                          H2O

                                          H2O

                                          Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                          [K+] =4

                                          Cell Membrane

                                          ICF

                                          Cell Membrane

                                          Na-

                                          K+

                                          Interstitial

                                          H2O

                                          H2O

                                          Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                          [K+] =4 [K+] =150

                                          Cell Membrane

                                          ICF

                                          Cell Membrane

                                          Na-

                                          K+

                                          Interstitial

                                          H2O

                                          H2O

                                          Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                          [K+] =4 [K+] =150

                                          Na+= 144

                                          Cell Membrane

                                          ICF

                                          Cell Membrane

                                          Na-

                                          K+

                                          Interstitial

                                          H2O

                                          H2O

                                          Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                          [K+] =4 [K+] =150

                                          Na+= 144Na+= 10

                                          Composition of Fluid Compartments

                                          CATIONS ANIONS

                                          Na+ 142 Cl - 103

                                          HC03- 27

                                          504mdash

                                          3 PO4

                                          ---

                                          K+ 4 organicCa++ 5 Acid 5

                                          Mg++ 3 Protein 16

                                          CATIONS ANIONS

                                          Na+ 144 Cl - 114

                                          HC03- 30

                                          504mdash

                                          K+ 4 3 PO4

                                          ---

                                          organic

                                          Ca++ 3 Acid 5

                                          Mg++ 2 Protein 1

                                          CATIONS ANIONS

                                          K+ 150 HPO4

                                          150 504

                                          mdash

                                          HCO3- 10

                                          Mg++ 40 Protein 40

                                          Na+ 10

                                          154 mEqL 153 mEqL 153 mEqL154 mEqL

                                          PLASMA INTERSTITAL FLID

                                          200 mEqL 200 mEqL

                                          INTRACELLULAR FLID

                                          Composition of Body FluidsComposition of Body Fluids

                                          Ca 2+

                                          Mg 2+

                                          K+

                                          Na+

                                          Cl-

                                          PO43-

                                          Organic anion

                                          HCO3-

                                          Protein

                                          0

                                          50

                                          50

                                          100

                                          150

                                          100

                                          150

                                          Cations Anions

                                          EC

                                          FICF

                                          Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                                          والکترولیت آب تغییرات روی موثر عوامل

                                          1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                                          عمل 2 از قبل والکترولیت آب وضعیت

                                          اندوکرینوپاتی )3 همراه )بیماریهای

                                          4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                                          Reasons for fluid therapyReasons for fluid therapy

                                          Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                                          bull Correct hypovolaemiaCorrect hypovolaemia

                                          bull Maintain cardiac outputMaintain cardiac output

                                          bull Optimise gas exchangeOptimise gas exchange

                                          bull Replace electrolytes amp waterReplace electrolytes amp water

                                          bull Maintain urine outputMaintain urine output

                                          Colloids + RBCs

                                          Crystalloids

                                          Identify what is the goal

                                          Choose fluid which best achieves the goal

                                          عروقی داخل مایع حجم ارزیابی

                                          بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                                          وریدی محلولهای

                                          Fluids bull Crystalloids

                                          bull Colloids

                                          bull blood

                                          Which of the following solutions is isotonic

                                          A D5W

                                          B 045 saline

                                          C 09 saline

                                          D D5 in 09 saline

                                          SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                                          ECFECF 142 4 5 103 27 280-310

                                          Lactated Lactated RingerrsquosRingerrsquos

                                          130 4 3 109 28 273

                                          09 NaCl09 NaCl 154 154 308

                                          045 045 NaClNaCl

                                          77 77 154

                                          D5WD5W

                                          D5045 D5045 NaClNaCl

                                          77 77 50 406

                                          3 NaCl3 NaCl 513 513 1026

                                          6 6 HetastarchHetastarch

                                          500 154 154 310

                                          5 5 AlbuminAlbumin

                                          250500130-160

                                          lt25130-160

                                          330

                                          25 25 AlbuminAlbumin

                                          2050100130-160

                                          lt25130-160

                                          330

                                          Common parenteral fluid therapyCommon parenteral fluid therapy

                                          CrystalloidsCrystalloids

                                          bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                          Colloid SolutionsColloid Solutions

                                          bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                          - Haes-steril 10

                                          الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                          کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                          ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                          osm=273

                                          09Nacl

                                          bull Na=154

                                          bull CL= 154

                                          کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                          PH=56است

                                          Postoperative (maintenance)

                                          045Nacl +5 dextrose +KCL

                                          Perioperative management of fluid balance include

                                          1 Preoperative evaluation

                                          2 Intraoperative maintenance

                                          3 Replacement of fluid losses

                                          Preexisting fluid deficits

                                          bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                          bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                          Maintenance requirements

                                          bull Up to 10 kg = 4cckghr

                                          bull 11-20kg = add 2cckghr

                                          bull 21kg and above = add 1cckghr

                                          bull Insensible losses = 2cckghr

                                          Surgical fluid losses

                                          Blood loss (measurement)

                                          1 Suction container

                                          2 Surgical sponge

                                          3 Hct and tachycardia not specific

                                          4 ABG and UO if hypoperfusion occur

                                          5 Blood loss=31 with crystalloid

                                          Other losses (third space loss)

                                          Third space loss

                                          1 Minimal (herniorrapy) =2-4cckghr

                                          2 Moderate (cholecystectomy)=4-6cckghr

                                          3 Severe (bowel resection) = 6-8cckghr

                                          Crystalloid solution

                                          1 The main solutions is either glucose or saline

                                          2 Hypotonic or isotonic or hypertonic

                                          3 Safe nontoxic reaction free inexpensive

                                          4 Complication is edema if large volumes are needed

                                          5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                          Colloids

                                          1 Albumin

                                          2 Hydroxyethyl starch

                                          3 Dextran

                                          Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                          factor )These colloid is best avoided in patients with

                                          coagulopaty

                                          The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                          1000cc

                                          500cc

                                          500cc

                                          500cc

                                          200

                                          600

                                          1000

                                          Lactated Ringers

                                          5 Albumin

                                          6 Hetastarch

                                          Whole blood

                                          Blood volumeInfusion volume

                                          Colloid versus crystalloid solutions

                                          Transfusion consideration

                                          bull HB lt7 mg dl increase CO

                                          bull Ideal Hb is 7-8 mgdl

                                          bull In IHD patients or pulmonary disease gt 10 mgdl

                                          بدن مایعات حجم در اختالل

                                          1 Fluid volume deficit

                                          2 Fluid volume excess

                                          Fluid volume deficit(FVD)

                                          ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                          کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                          ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                          باشد آن با همراه دیگری اختالل مگر

                                          DEHYDRATION

                                          سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                          سلولی خارج حجم کاهش علل

                                          1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                          2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                          کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                          Signs of HypovolemiaSigns of Hypovolemia

                                          bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                          Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                          bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                          Signs of HypervolemiaSigns of Hypervolemia

                                          bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                          Especially when hypo-albuminemia

                                          Management of Management of HypervolemiaHypervolemia

                                          bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                          Fluid ManagementFluid Management

                                          bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                          Electrolyte physiology

                                          Sodium physiology

                                          Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                          Normal amount 135-145 meql

                                          Osmotic Pressure

                                          Calculated serum osmolality =

                                          2 sodium+ glucose18 + BUN 28

                                          Osmolality = 290 mosm

                                          Concentration

                                          1Serum sodium concentration2Serum osmolarity

                                          bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                          drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                          DW5)

                                          Hypernatremia

                                          Serum Nagt145mEqL

                                          - Hypernatremia

                                          Loss of Free Water

                                          Gain of sodium in excess of water

                                          Hypernatremia

                                          -Hypernatremia Hypo volemic

                                          Hyper volemic

                                          Normo volemic

                                          Hypernatremia

                                          Volume Status

                                          Normal

                                          Nonrenal water loss

                                          Skin

                                          Gastrointestinal

                                          Renal water loss

                                          Renal disease

                                          Diuretics

                                          Diabetes insipidus

                                          High

                                          Iatrogenic sodium administration

                                          Mineralocorticoid excess

                                          Aldosteronism

                                          Cushingrsquos disease

                                          Congenital adrenal

                                          hyperplasia

                                          Low

                                          Nonrenal water loss

                                          Skin

                                          Gastrointestinal losses

                                          Renal water losses

                                          Renal (tubular) Diuretics

                                          Osmotic diuretics

                                          Diabetes insipidus

                                          Adrenal failure

                                          Asymptomatic

                                          Hypernatremia Symptomatic (Nagt160 meqL)

                                          Clinical Manifestations of Abnormalities in Serum Sodium

                                          Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                          Body system hypernatremia

                                          Treatment

                                          Normal saline in hypovolemic patients

                                          Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                          saline or entral water)

                                          Water deficit (L)= times TBW

                                          The formula used to estimate the amount of water required to correct hypernatremia

                                          Estimate TBW as 55 of lean body mass in men and 45 in women

                                          Serum sodium-140

                                          140

                                          The rate of fluid administration

                                          1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                          2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                          Hyponatremia Nalt135mEqL

                                          Causes

                                          1 Sodium depletion

                                          2 Sodium dilution

                                          bull Incidence = 45

                                          bull After surgery=1

                                          bull Mortality = 2 times normal

                                          Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                          volume deficit

                                          Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                          Sign and symptoms

                                          bull CNS symptom when Nalt123 meql

                                          bull Cardiac symptom when Nalt100 meql

                                          For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                          Body System Hyponatremia

                                          central nervous system Headache confusion hyper-or hypoactive deep tendon

                                          reflexes seizures coma increased intracranial pressure

                                          Musculoskeletal Weakness fatigue muscle crampstwitching

                                          Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                          Cardiovascular Hypertension and bradycardia if significant increases in

                                          intracranial pressure

                                          Tissue Lacrimation salivation

                                          Renal Oliguria

                                          Clinical Manifestations of Abnormalities in Serum Sodium

                                          Treatment

                                          1=Depend on ECF

                                          2=CNS sign

                                          Treatment

                                          1 Asymptomatic increase the sodium level by no more than

                                          05-1 meqLh to a maximum increase of 12 meqL per day

                                          2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                          more than 1meqL per hour until the serum Na level reaches 130

                                          meqL or neurologic symptoms are improved

                                          Rapid correction of hyponatremia

                                          Pontine myelinolysis

                                          Seizures weaknessparesis akinetic

                                          movements unresponsiveness

                                          Permanent brain damage

                                          Death

                                          Dose

                                          Na deficit meq =(140- Na meql) TBW

                                          باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                          شود اصالح آهسته سپس

                                          Potassium abnormalities

                                          bull The average dietary intake of potassium 50-100meqd

                                          bull The average renal excretion of potassium 10-700 meqd

                                          - 2 of the total body potassium in ECF (45meqL)

                                          - Factors that influence serum potassium

                                          1 Surgical stress

                                          2 Injury

                                          3 Acidosis

                                          4 Tissue catabolism

                                          Hyperkalemia

                                          The normal range of serum potassium 35-5 meqL

                                          Etiology of Hyperkalemia

                                          Increased intake Potassium supplementation

                                          Blood transfusions

                                          Endogenous loaddestruction

                                          hemolysis rhabdomyolysis

                                          cruch injury gastrointestinal hemorrhage

                                          Increased release Acidosis

                                          Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                          Renal insufficiencyfailure

                                          Clinical manifestation of hyperkalemia

                                          System hyperkalemia

                                          Gastrointestinal Nauseavomiting colic diarrhea

                                          Neuromuscular weakness paralysis respiratory failure

                                          Cardiovascular Arrhythmia arrest

                                          ECG changes Peaked T waves (early change)

                                          Flattened P wave

                                          Prolonged PR interval (first-degree block)

                                          Widened QRS complex

                                          Sine wave formation

                                          Ventricular fibrillation

                                          Treatment

                                          Treatment of symptomatic hyperkalemia

                                          Potassium removal Kayexalate

                                          Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                          Rectal administration is 50 g in 200 mL 20 sorbitol

                                          Dialysis

                                          Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                          Bicarbonate 1 vial intravenous

                                          Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                          HypokalemiaEtiology

                                          inadequate intake

                                          Dietary potassium-free intravenous fluids potassium-deficient

                                          total parenteral nutrition

                                          Excessive potassium excretion

                                          Hyperaldosteronism

                                          Medications

                                          Gastrointestinal losses

                                          Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                          Renal loss of potassium (gastric fluid either as vomiting or high

                                          nasogastric output)

                                          Intracellular-shift (metabolic alkalosis or insulin therapy)

                                          Potassium changes associated with alkalosis

                                          Potassium decrease by 03 meqL for every 01

                                          increase in PH above normal

                                          Magnesium Depletion

                                          (drug induced amphotericin amioglycosides cisplatin)

                                          Renal potassium wastage

                                          Hypokalemia

                                          Magnesium Depletion

                                          (drug induced amphotericin amioglycosides cisplatin)

                                          Renal potassium wastage

                                          Hypokalemia

                                          Clinical Manifestation of Abnormalities in potassium

                                          System hypokalemia

                                          Gastrointestinal Ileus constipation

                                          Neuromuscular Decreased reflexes fatigue weakness

                                          paralysis

                                          Cardiovascular Arrest

                                          ECG changes U-waves

                                          T-wave flattening

                                          ST-segment changes

                                          Arrhythmias

                                          Treatment

                                          Potassium

                                          Serum potassium level lt40 mEqL

                                          Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                          times 1 doses

                                          Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                          Symptomatic KC1 20 mEq IV q1h times 4 doses

                                          Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                          asymptomatic replace as per above protocol

                                          Electrolyte Replacement Therapy Protocol

                                          bull Oral repletion for mild and asymptomatic hypokalemia

                                          bull IV repletion for severe and symptomatic hypokalemia

                                          Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                          ( دندانها( ndash استخوانbull كلسيم نقش

                                          عصبي 1 ايمپالسهاي )NMJ(انتقال

                                          صاف 2 عضالت انقباض

                                          هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                          انعقاد 4

                                          یونیزه Calt45 meql هيپوكلسمي

                                          عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                          ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                          میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                          ( شود می پیوند شده

                                          هیپوکلسمی عالئم

                                          رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                          سایرعالئم

                                          قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                          درمان

                                          ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                          Cagt55meql هيپركلسمي

                                          هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                          عالئم

                                          bullGI

                                          bullCardiovascular bullRenal (polyuria)

                                          bullCNS

                                          قلبی عالئم

                                          bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                          QRS شدن )Q-Tوكوتاه

                                          درمان

                                          ایزوتونیک 1 نمکی محلول انفوزیون

                                          الزیکس2

                                          تونین 3 کلسی

                                          کورتون4

                                          دیالیز5

                                          Magnesium Abnormalities

                                          Normal dietary intake 20meq (240mg)

                                          Excretion in both the feces and urine

                                          Normal serum level 19-25 mgdL

                                          منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                          تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                          bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                          Hypermagnesemia

                                          Etiology

                                          1 Impaired renal function

                                          2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                          Clinical manifestation hypermanesemia

                                          System hypermanesemia

                                          Gastrointestinal Nauseavomiting

                                          Neuromuscular weakness lethargy Decreased

                                          reflexes

                                          Cardiovascular Hypotension arrest

                                          ECG changes Increased PR interval

                                          Widened QRS complex

                                          Elevated T waves

                                          Treatment

                                          1 Withhold exogenous sources of magnesium

                                          2 Correct volume deficit

                                          3 Correct acidosis if present

                                          4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                          5 Dialysis (if elevated levels or symptoms persist)

                                          عالئم

                                          bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                          meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                          meqL

                                          Hypomagnesemia

                                          Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                          homeostasis

                                          Etiology

                                          1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                          inadequate supplementation of magnesium)

                                          2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                          3 GI losses (diarrhea)

                                          4 Malabsorption

                                          5 Acute pancreatitis

                                          6 Diabetic ketoacidosis

                                          7 Primary aldosteronism

                                          Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                          1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                          2 Delirium and seizures in severe deficiency

                                          3 ECG changes Prolonged QT and PR interval

                                          ST-segment depression

                                          Flattening or inversion of P waves

                                          Torsades de pointes

                                          Arrhythmia

                                          Treatment

                                          1 For asymptomatic and mild hypomagnesemia administer oral mg

                                          2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                          Message for Today

                                          ICF

                                          Interstitial

                                          Pla

                                          sma

                                          5 Dex

                                          bull Do not reccussitate sick patients with any Dextrose solution

                                          • Fluid and Electrolyte Management of the Surgical Patient
                                          • Slide 2
                                          • Slide 3
                                          • Slide 4
                                          • Total Body Water
                                          • Body Fluid Compartments
                                          • Total body water (TBW)
                                          • Body compartment fluid
                                          • Example men with 70kg
                                          • Fluid compartments
                                          • Slide 11
                                          • Slide 12
                                          • Slide 13
                                          • Slide 14
                                          • Slide 15
                                          • Colloid osmotic pressure
                                          • Slide 17
                                          • Slide 18
                                          • Slide 19
                                          • Cell Membrane
                                          • Slide 21
                                          • Slide 22
                                          • Slide 23
                                          • Slide 24
                                          • Slide 25
                                          • Composition of Fluid Compartments
                                          • Composition of Body Fluids
                                          • عوامل موثر روی تغییرات آب والکترولیت
                                          • Reasons for fluid therapy
                                          • ارزیابی حجم مایع داخل عروقی
                                          • محلولهای وریدی
                                          • Fluids
                                          • Slide 33
                                          • Slide 34
                                          • Slide 35
                                          • Crystalloids
                                          • Colloid Solutions
                                          • رینگر لاکتات
                                          • 09Nacl
                                          • Postoperative (maintenance)
                                          • Slide 41
                                          • Preexisting fluid deficits
                                          • Maintenance requirements
                                          • Surgical fluid losses
                                          • Third space loss
                                          • Crystalloid solution
                                          • Colloids
                                          • Complications
                                          • The Influence of Colloid amp Crystalloid on Blood Volume
                                          • Colloid versus crystalloid solutions
                                          • Transfusion consideration
                                          • اختلال در حجم مایعات بدن
                                          • Fluid volume deficit (FVD)
                                          • DEHYDRATION
                                          • علل کاهش حجم خارج سلولی
                                          • Signs of Hypovolemia
                                          • Clinical Diagnosis of Hypovolemia
                                          • Signs of Hypervolemia
                                          • Management of Hypervolemia
                                          • Fluid Management
                                          • Electrolyte physiology
                                          • Sodium physiology
                                          • Osmotic Pressure
                                          • Concentration
                                          • Hypernatremia
                                          • - Hypernatremia
                                          • Slide 67
                                          • Slide 68
                                          • Clinical Manifestations of Abnormalities in Serum Sodium
                                          • Treatment
                                          • Water deficit (L)= times TBW
                                          • The rate of fluid administration
                                          • Hyponatremia Nalt135mEqL
                                          • Slide 74
                                          • Sodium depletion
                                          • Sodium dilution
                                          • Sign and symptoms
                                          • Slide 78
                                          • Treatment
                                          • Slide 80
                                          • Slide 81
                                          • Dose
                                          • Potassium abnormalities
                                          • Hyperkalemia
                                          • Clinical manifestation of hyperkalemia
                                          • Slide 86
                                          • Slide 87
                                          • Hypokalemia
                                          • Potassium changes associated with alkalosis
                                          • Slide 90
                                          • Clinical Manifestation of Abnormalities in potassium
                                          • Slide 92
                                          • Calcium
                                          • هيپوكلسمي یونیزه Calt45 meql
                                          • علائم هیپوکلسمی
                                          • Slide 96
                                          • Slide 97
                                          • Slide 98
                                          • Slide 99
                                          • سایرعلائم
                                          • درمان
                                          • هيپركلسمي Cagt55meql
                                          • علائم
                                          • علائم قلبی
                                          • Slide 105
                                          • Magnesium Abnormalities
                                          • منیزیوم
                                          • Hypermagnesemia
                                          • Clinical manifestation hypermanesemia
                                          • Slide 110
                                          • Slide 111
                                          • Hypomagnesemia
                                          • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                          • Slide 114
                                          • Message for Today
                                          • Slide 116

                                            Cell Membrane

                                            ICF

                                            Cell Membrane

                                            Na-

                                            K+

                                            Interstitial

                                            H2O

                                            H2O

                                            Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                            [K+] =4

                                            Cell Membrane

                                            ICF

                                            Cell Membrane

                                            Na-

                                            K+

                                            Interstitial

                                            H2O

                                            H2O

                                            Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                            [K+] =4 [K+] =150

                                            Cell Membrane

                                            ICF

                                            Cell Membrane

                                            Na-

                                            K+

                                            Interstitial

                                            H2O

                                            H2O

                                            Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                            [K+] =4 [K+] =150

                                            Na+= 144

                                            Cell Membrane

                                            ICF

                                            Cell Membrane

                                            Na-

                                            K+

                                            Interstitial

                                            H2O

                                            H2O

                                            Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                            [K+] =4 [K+] =150

                                            Na+= 144Na+= 10

                                            Composition of Fluid Compartments

                                            CATIONS ANIONS

                                            Na+ 142 Cl - 103

                                            HC03- 27

                                            504mdash

                                            3 PO4

                                            ---

                                            K+ 4 organicCa++ 5 Acid 5

                                            Mg++ 3 Protein 16

                                            CATIONS ANIONS

                                            Na+ 144 Cl - 114

                                            HC03- 30

                                            504mdash

                                            K+ 4 3 PO4

                                            ---

                                            organic

                                            Ca++ 3 Acid 5

                                            Mg++ 2 Protein 1

                                            CATIONS ANIONS

                                            K+ 150 HPO4

                                            150 504

                                            mdash

                                            HCO3- 10

                                            Mg++ 40 Protein 40

                                            Na+ 10

                                            154 mEqL 153 mEqL 153 mEqL154 mEqL

                                            PLASMA INTERSTITAL FLID

                                            200 mEqL 200 mEqL

                                            INTRACELLULAR FLID

                                            Composition of Body FluidsComposition of Body Fluids

                                            Ca 2+

                                            Mg 2+

                                            K+

                                            Na+

                                            Cl-

                                            PO43-

                                            Organic anion

                                            HCO3-

                                            Protein

                                            0

                                            50

                                            50

                                            100

                                            150

                                            100

                                            150

                                            Cations Anions

                                            EC

                                            FICF

                                            Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                                            والکترولیت آب تغییرات روی موثر عوامل

                                            1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                                            عمل 2 از قبل والکترولیت آب وضعیت

                                            اندوکرینوپاتی )3 همراه )بیماریهای

                                            4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                                            Reasons for fluid therapyReasons for fluid therapy

                                            Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                                            bull Correct hypovolaemiaCorrect hypovolaemia

                                            bull Maintain cardiac outputMaintain cardiac output

                                            bull Optimise gas exchangeOptimise gas exchange

                                            bull Replace electrolytes amp waterReplace electrolytes amp water

                                            bull Maintain urine outputMaintain urine output

                                            Colloids + RBCs

                                            Crystalloids

                                            Identify what is the goal

                                            Choose fluid which best achieves the goal

                                            عروقی داخل مایع حجم ارزیابی

                                            بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                                            وریدی محلولهای

                                            Fluids bull Crystalloids

                                            bull Colloids

                                            bull blood

                                            Which of the following solutions is isotonic

                                            A D5W

                                            B 045 saline

                                            C 09 saline

                                            D D5 in 09 saline

                                            SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                                            ECFECF 142 4 5 103 27 280-310

                                            Lactated Lactated RingerrsquosRingerrsquos

                                            130 4 3 109 28 273

                                            09 NaCl09 NaCl 154 154 308

                                            045 045 NaClNaCl

                                            77 77 154

                                            D5WD5W

                                            D5045 D5045 NaClNaCl

                                            77 77 50 406

                                            3 NaCl3 NaCl 513 513 1026

                                            6 6 HetastarchHetastarch

                                            500 154 154 310

                                            5 5 AlbuminAlbumin

                                            250500130-160

                                            lt25130-160

                                            330

                                            25 25 AlbuminAlbumin

                                            2050100130-160

                                            lt25130-160

                                            330

                                            Common parenteral fluid therapyCommon parenteral fluid therapy

                                            CrystalloidsCrystalloids

                                            bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                            Colloid SolutionsColloid Solutions

                                            bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                            - Haes-steril 10

                                            الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                            کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                            ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                            osm=273

                                            09Nacl

                                            bull Na=154

                                            bull CL= 154

                                            کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                            PH=56است

                                            Postoperative (maintenance)

                                            045Nacl +5 dextrose +KCL

                                            Perioperative management of fluid balance include

                                            1 Preoperative evaluation

                                            2 Intraoperative maintenance

                                            3 Replacement of fluid losses

                                            Preexisting fluid deficits

                                            bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                            bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                            Maintenance requirements

                                            bull Up to 10 kg = 4cckghr

                                            bull 11-20kg = add 2cckghr

                                            bull 21kg and above = add 1cckghr

                                            bull Insensible losses = 2cckghr

                                            Surgical fluid losses

                                            Blood loss (measurement)

                                            1 Suction container

                                            2 Surgical sponge

                                            3 Hct and tachycardia not specific

                                            4 ABG and UO if hypoperfusion occur

                                            5 Blood loss=31 with crystalloid

                                            Other losses (third space loss)

                                            Third space loss

                                            1 Minimal (herniorrapy) =2-4cckghr

                                            2 Moderate (cholecystectomy)=4-6cckghr

                                            3 Severe (bowel resection) = 6-8cckghr

                                            Crystalloid solution

                                            1 The main solutions is either glucose or saline

                                            2 Hypotonic or isotonic or hypertonic

                                            3 Safe nontoxic reaction free inexpensive

                                            4 Complication is edema if large volumes are needed

                                            5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                            Colloids

                                            1 Albumin

                                            2 Hydroxyethyl starch

                                            3 Dextran

                                            Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                            factor )These colloid is best avoided in patients with

                                            coagulopaty

                                            The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                            1000cc

                                            500cc

                                            500cc

                                            500cc

                                            200

                                            600

                                            1000

                                            Lactated Ringers

                                            5 Albumin

                                            6 Hetastarch

                                            Whole blood

                                            Blood volumeInfusion volume

                                            Colloid versus crystalloid solutions

                                            Transfusion consideration

                                            bull HB lt7 mg dl increase CO

                                            bull Ideal Hb is 7-8 mgdl

                                            bull In IHD patients or pulmonary disease gt 10 mgdl

                                            بدن مایعات حجم در اختالل

                                            1 Fluid volume deficit

                                            2 Fluid volume excess

                                            Fluid volume deficit(FVD)

                                            ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                            کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                            ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                            باشد آن با همراه دیگری اختالل مگر

                                            DEHYDRATION

                                            سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                            سلولی خارج حجم کاهش علل

                                            1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                            2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                            کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                            Signs of HypovolemiaSigns of Hypovolemia

                                            bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                            Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                            bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                            Signs of HypervolemiaSigns of Hypervolemia

                                            bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                            Especially when hypo-albuminemia

                                            Management of Management of HypervolemiaHypervolemia

                                            bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                            Fluid ManagementFluid Management

                                            bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                            Electrolyte physiology

                                            Sodium physiology

                                            Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                            Normal amount 135-145 meql

                                            Osmotic Pressure

                                            Calculated serum osmolality =

                                            2 sodium+ glucose18 + BUN 28

                                            Osmolality = 290 mosm

                                            Concentration

                                            1Serum sodium concentration2Serum osmolarity

                                            bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                            drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                            DW5)

                                            Hypernatremia

                                            Serum Nagt145mEqL

                                            - Hypernatremia

                                            Loss of Free Water

                                            Gain of sodium in excess of water

                                            Hypernatremia

                                            -Hypernatremia Hypo volemic

                                            Hyper volemic

                                            Normo volemic

                                            Hypernatremia

                                            Volume Status

                                            Normal

                                            Nonrenal water loss

                                            Skin

                                            Gastrointestinal

                                            Renal water loss

                                            Renal disease

                                            Diuretics

                                            Diabetes insipidus

                                            High

                                            Iatrogenic sodium administration

                                            Mineralocorticoid excess

                                            Aldosteronism

                                            Cushingrsquos disease

                                            Congenital adrenal

                                            hyperplasia

                                            Low

                                            Nonrenal water loss

                                            Skin

                                            Gastrointestinal losses

                                            Renal water losses

                                            Renal (tubular) Diuretics

                                            Osmotic diuretics

                                            Diabetes insipidus

                                            Adrenal failure

                                            Asymptomatic

                                            Hypernatremia Symptomatic (Nagt160 meqL)

                                            Clinical Manifestations of Abnormalities in Serum Sodium

                                            Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                            Body system hypernatremia

                                            Treatment

                                            Normal saline in hypovolemic patients

                                            Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                            saline or entral water)

                                            Water deficit (L)= times TBW

                                            The formula used to estimate the amount of water required to correct hypernatremia

                                            Estimate TBW as 55 of lean body mass in men and 45 in women

                                            Serum sodium-140

                                            140

                                            The rate of fluid administration

                                            1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                            2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                            Hyponatremia Nalt135mEqL

                                            Causes

                                            1 Sodium depletion

                                            2 Sodium dilution

                                            bull Incidence = 45

                                            bull After surgery=1

                                            bull Mortality = 2 times normal

                                            Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                            volume deficit

                                            Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                            Sign and symptoms

                                            bull CNS symptom when Nalt123 meql

                                            bull Cardiac symptom when Nalt100 meql

                                            For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                            Body System Hyponatremia

                                            central nervous system Headache confusion hyper-or hypoactive deep tendon

                                            reflexes seizures coma increased intracranial pressure

                                            Musculoskeletal Weakness fatigue muscle crampstwitching

                                            Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                            Cardiovascular Hypertension and bradycardia if significant increases in

                                            intracranial pressure

                                            Tissue Lacrimation salivation

                                            Renal Oliguria

                                            Clinical Manifestations of Abnormalities in Serum Sodium

                                            Treatment

                                            1=Depend on ECF

                                            2=CNS sign

                                            Treatment

                                            1 Asymptomatic increase the sodium level by no more than

                                            05-1 meqLh to a maximum increase of 12 meqL per day

                                            2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                            more than 1meqL per hour until the serum Na level reaches 130

                                            meqL or neurologic symptoms are improved

                                            Rapid correction of hyponatremia

                                            Pontine myelinolysis

                                            Seizures weaknessparesis akinetic

                                            movements unresponsiveness

                                            Permanent brain damage

                                            Death

                                            Dose

                                            Na deficit meq =(140- Na meql) TBW

                                            باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                            شود اصالح آهسته سپس

                                            Potassium abnormalities

                                            bull The average dietary intake of potassium 50-100meqd

                                            bull The average renal excretion of potassium 10-700 meqd

                                            - 2 of the total body potassium in ECF (45meqL)

                                            - Factors that influence serum potassium

                                            1 Surgical stress

                                            2 Injury

                                            3 Acidosis

                                            4 Tissue catabolism

                                            Hyperkalemia

                                            The normal range of serum potassium 35-5 meqL

                                            Etiology of Hyperkalemia

                                            Increased intake Potassium supplementation

                                            Blood transfusions

                                            Endogenous loaddestruction

                                            hemolysis rhabdomyolysis

                                            cruch injury gastrointestinal hemorrhage

                                            Increased release Acidosis

                                            Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                            Renal insufficiencyfailure

                                            Clinical manifestation of hyperkalemia

                                            System hyperkalemia

                                            Gastrointestinal Nauseavomiting colic diarrhea

                                            Neuromuscular weakness paralysis respiratory failure

                                            Cardiovascular Arrhythmia arrest

                                            ECG changes Peaked T waves (early change)

                                            Flattened P wave

                                            Prolonged PR interval (first-degree block)

                                            Widened QRS complex

                                            Sine wave formation

                                            Ventricular fibrillation

                                            Treatment

                                            Treatment of symptomatic hyperkalemia

                                            Potassium removal Kayexalate

                                            Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                            Rectal administration is 50 g in 200 mL 20 sorbitol

                                            Dialysis

                                            Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                            Bicarbonate 1 vial intravenous

                                            Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                            HypokalemiaEtiology

                                            inadequate intake

                                            Dietary potassium-free intravenous fluids potassium-deficient

                                            total parenteral nutrition

                                            Excessive potassium excretion

                                            Hyperaldosteronism

                                            Medications

                                            Gastrointestinal losses

                                            Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                            Renal loss of potassium (gastric fluid either as vomiting or high

                                            nasogastric output)

                                            Intracellular-shift (metabolic alkalosis or insulin therapy)

                                            Potassium changes associated with alkalosis

                                            Potassium decrease by 03 meqL for every 01

                                            increase in PH above normal

                                            Magnesium Depletion

                                            (drug induced amphotericin amioglycosides cisplatin)

                                            Renal potassium wastage

                                            Hypokalemia

                                            Magnesium Depletion

                                            (drug induced amphotericin amioglycosides cisplatin)

                                            Renal potassium wastage

                                            Hypokalemia

                                            Clinical Manifestation of Abnormalities in potassium

                                            System hypokalemia

                                            Gastrointestinal Ileus constipation

                                            Neuromuscular Decreased reflexes fatigue weakness

                                            paralysis

                                            Cardiovascular Arrest

                                            ECG changes U-waves

                                            T-wave flattening

                                            ST-segment changes

                                            Arrhythmias

                                            Treatment

                                            Potassium

                                            Serum potassium level lt40 mEqL

                                            Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                            times 1 doses

                                            Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                            Symptomatic KC1 20 mEq IV q1h times 4 doses

                                            Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                            asymptomatic replace as per above protocol

                                            Electrolyte Replacement Therapy Protocol

                                            bull Oral repletion for mild and asymptomatic hypokalemia

                                            bull IV repletion for severe and symptomatic hypokalemia

                                            Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                            ( دندانها( ndash استخوانbull كلسيم نقش

                                            عصبي 1 ايمپالسهاي )NMJ(انتقال

                                            صاف 2 عضالت انقباض

                                            هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                            انعقاد 4

                                            یونیزه Calt45 meql هيپوكلسمي

                                            عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                            ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                            میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                            ( شود می پیوند شده

                                            هیپوکلسمی عالئم

                                            رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                            سایرعالئم

                                            قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                            درمان

                                            ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                            Cagt55meql هيپركلسمي

                                            هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                            عالئم

                                            bullGI

                                            bullCardiovascular bullRenal (polyuria)

                                            bullCNS

                                            قلبی عالئم

                                            bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                            QRS شدن )Q-Tوكوتاه

                                            درمان

                                            ایزوتونیک 1 نمکی محلول انفوزیون

                                            الزیکس2

                                            تونین 3 کلسی

                                            کورتون4

                                            دیالیز5

                                            Magnesium Abnormalities

                                            Normal dietary intake 20meq (240mg)

                                            Excretion in both the feces and urine

                                            Normal serum level 19-25 mgdL

                                            منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                            تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                            bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                            Hypermagnesemia

                                            Etiology

                                            1 Impaired renal function

                                            2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                            Clinical manifestation hypermanesemia

                                            System hypermanesemia

                                            Gastrointestinal Nauseavomiting

                                            Neuromuscular weakness lethargy Decreased

                                            reflexes

                                            Cardiovascular Hypotension arrest

                                            ECG changes Increased PR interval

                                            Widened QRS complex

                                            Elevated T waves

                                            Treatment

                                            1 Withhold exogenous sources of magnesium

                                            2 Correct volume deficit

                                            3 Correct acidosis if present

                                            4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                            5 Dialysis (if elevated levels or symptoms persist)

                                            عالئم

                                            bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                            meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                            meqL

                                            Hypomagnesemia

                                            Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                            homeostasis

                                            Etiology

                                            1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                            inadequate supplementation of magnesium)

                                            2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                            3 GI losses (diarrhea)

                                            4 Malabsorption

                                            5 Acute pancreatitis

                                            6 Diabetic ketoacidosis

                                            7 Primary aldosteronism

                                            Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                            1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                            2 Delirium and seizures in severe deficiency

                                            3 ECG changes Prolonged QT and PR interval

                                            ST-segment depression

                                            Flattening or inversion of P waves

                                            Torsades de pointes

                                            Arrhythmia

                                            Treatment

                                            1 For asymptomatic and mild hypomagnesemia administer oral mg

                                            2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                            Message for Today

                                            ICF

                                            Interstitial

                                            Pla

                                            sma

                                            5 Dex

                                            bull Do not reccussitate sick patients with any Dextrose solution

                                            • Fluid and Electrolyte Management of the Surgical Patient
                                            • Slide 2
                                            • Slide 3
                                            • Slide 4
                                            • Total Body Water
                                            • Body Fluid Compartments
                                            • Total body water (TBW)
                                            • Body compartment fluid
                                            • Example men with 70kg
                                            • Fluid compartments
                                            • Slide 11
                                            • Slide 12
                                            • Slide 13
                                            • Slide 14
                                            • Slide 15
                                            • Colloid osmotic pressure
                                            • Slide 17
                                            • Slide 18
                                            • Slide 19
                                            • Cell Membrane
                                            • Slide 21
                                            • Slide 22
                                            • Slide 23
                                            • Slide 24
                                            • Slide 25
                                            • Composition of Fluid Compartments
                                            • Composition of Body Fluids
                                            • عوامل موثر روی تغییرات آب والکترولیت
                                            • Reasons for fluid therapy
                                            • ارزیابی حجم مایع داخل عروقی
                                            • محلولهای وریدی
                                            • Fluids
                                            • Slide 33
                                            • Slide 34
                                            • Slide 35
                                            • Crystalloids
                                            • Colloid Solutions
                                            • رینگر لاکتات
                                            • 09Nacl
                                            • Postoperative (maintenance)
                                            • Slide 41
                                            • Preexisting fluid deficits
                                            • Maintenance requirements
                                            • Surgical fluid losses
                                            • Third space loss
                                            • Crystalloid solution
                                            • Colloids
                                            • Complications
                                            • The Influence of Colloid amp Crystalloid on Blood Volume
                                            • Colloid versus crystalloid solutions
                                            • Transfusion consideration
                                            • اختلال در حجم مایعات بدن
                                            • Fluid volume deficit (FVD)
                                            • DEHYDRATION
                                            • علل کاهش حجم خارج سلولی
                                            • Signs of Hypovolemia
                                            • Clinical Diagnosis of Hypovolemia
                                            • Signs of Hypervolemia
                                            • Management of Hypervolemia
                                            • Fluid Management
                                            • Electrolyte physiology
                                            • Sodium physiology
                                            • Osmotic Pressure
                                            • Concentration
                                            • Hypernatremia
                                            • - Hypernatremia
                                            • Slide 67
                                            • Slide 68
                                            • Clinical Manifestations of Abnormalities in Serum Sodium
                                            • Treatment
                                            • Water deficit (L)= times TBW
                                            • The rate of fluid administration
                                            • Hyponatremia Nalt135mEqL
                                            • Slide 74
                                            • Sodium depletion
                                            • Sodium dilution
                                            • Sign and symptoms
                                            • Slide 78
                                            • Treatment
                                            • Slide 80
                                            • Slide 81
                                            • Dose
                                            • Potassium abnormalities
                                            • Hyperkalemia
                                            • Clinical manifestation of hyperkalemia
                                            • Slide 86
                                            • Slide 87
                                            • Hypokalemia
                                            • Potassium changes associated with alkalosis
                                            • Slide 90
                                            • Clinical Manifestation of Abnormalities in potassium
                                            • Slide 92
                                            • Calcium
                                            • هيپوكلسمي یونیزه Calt45 meql
                                            • علائم هیپوکلسمی
                                            • Slide 96
                                            • Slide 97
                                            • Slide 98
                                            • Slide 99
                                            • سایرعلائم
                                            • درمان
                                            • هيپركلسمي Cagt55meql
                                            • علائم
                                            • علائم قلبی
                                            • Slide 105
                                            • Magnesium Abnormalities
                                            • منیزیوم
                                            • Hypermagnesemia
                                            • Clinical manifestation hypermanesemia
                                            • Slide 110
                                            • Slide 111
                                            • Hypomagnesemia
                                            • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                            • Slide 114
                                            • Message for Today
                                            • Slide 116

                                              Cell Membrane

                                              ICF

                                              Cell Membrane

                                              Na-

                                              K+

                                              Interstitial

                                              H2O

                                              H2O

                                              Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                              [K+] =4 [K+] =150

                                              Cell Membrane

                                              ICF

                                              Cell Membrane

                                              Na-

                                              K+

                                              Interstitial

                                              H2O

                                              H2O

                                              Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                              [K+] =4 [K+] =150

                                              Na+= 144

                                              Cell Membrane

                                              ICF

                                              Cell Membrane

                                              Na-

                                              K+

                                              Interstitial

                                              H2O

                                              H2O

                                              Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                              [K+] =4 [K+] =150

                                              Na+= 144Na+= 10

                                              Composition of Fluid Compartments

                                              CATIONS ANIONS

                                              Na+ 142 Cl - 103

                                              HC03- 27

                                              504mdash

                                              3 PO4

                                              ---

                                              K+ 4 organicCa++ 5 Acid 5

                                              Mg++ 3 Protein 16

                                              CATIONS ANIONS

                                              Na+ 144 Cl - 114

                                              HC03- 30

                                              504mdash

                                              K+ 4 3 PO4

                                              ---

                                              organic

                                              Ca++ 3 Acid 5

                                              Mg++ 2 Protein 1

                                              CATIONS ANIONS

                                              K+ 150 HPO4

                                              150 504

                                              mdash

                                              HCO3- 10

                                              Mg++ 40 Protein 40

                                              Na+ 10

                                              154 mEqL 153 mEqL 153 mEqL154 mEqL

                                              PLASMA INTERSTITAL FLID

                                              200 mEqL 200 mEqL

                                              INTRACELLULAR FLID

                                              Composition of Body FluidsComposition of Body Fluids

                                              Ca 2+

                                              Mg 2+

                                              K+

                                              Na+

                                              Cl-

                                              PO43-

                                              Organic anion

                                              HCO3-

                                              Protein

                                              0

                                              50

                                              50

                                              100

                                              150

                                              100

                                              150

                                              Cations Anions

                                              EC

                                              FICF

                                              Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                                              والکترولیت آب تغییرات روی موثر عوامل

                                              1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                                              عمل 2 از قبل والکترولیت آب وضعیت

                                              اندوکرینوپاتی )3 همراه )بیماریهای

                                              4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                                              Reasons for fluid therapyReasons for fluid therapy

                                              Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                                              bull Correct hypovolaemiaCorrect hypovolaemia

                                              bull Maintain cardiac outputMaintain cardiac output

                                              bull Optimise gas exchangeOptimise gas exchange

                                              bull Replace electrolytes amp waterReplace electrolytes amp water

                                              bull Maintain urine outputMaintain urine output

                                              Colloids + RBCs

                                              Crystalloids

                                              Identify what is the goal

                                              Choose fluid which best achieves the goal

                                              عروقی داخل مایع حجم ارزیابی

                                              بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                                              وریدی محلولهای

                                              Fluids bull Crystalloids

                                              bull Colloids

                                              bull blood

                                              Which of the following solutions is isotonic

                                              A D5W

                                              B 045 saline

                                              C 09 saline

                                              D D5 in 09 saline

                                              SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                                              ECFECF 142 4 5 103 27 280-310

                                              Lactated Lactated RingerrsquosRingerrsquos

                                              130 4 3 109 28 273

                                              09 NaCl09 NaCl 154 154 308

                                              045 045 NaClNaCl

                                              77 77 154

                                              D5WD5W

                                              D5045 D5045 NaClNaCl

                                              77 77 50 406

                                              3 NaCl3 NaCl 513 513 1026

                                              6 6 HetastarchHetastarch

                                              500 154 154 310

                                              5 5 AlbuminAlbumin

                                              250500130-160

                                              lt25130-160

                                              330

                                              25 25 AlbuminAlbumin

                                              2050100130-160

                                              lt25130-160

                                              330

                                              Common parenteral fluid therapyCommon parenteral fluid therapy

                                              CrystalloidsCrystalloids

                                              bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                              Colloid SolutionsColloid Solutions

                                              bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                              - Haes-steril 10

                                              الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                              کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                              ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                              osm=273

                                              09Nacl

                                              bull Na=154

                                              bull CL= 154

                                              کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                              PH=56است

                                              Postoperative (maintenance)

                                              045Nacl +5 dextrose +KCL

                                              Perioperative management of fluid balance include

                                              1 Preoperative evaluation

                                              2 Intraoperative maintenance

                                              3 Replacement of fluid losses

                                              Preexisting fluid deficits

                                              bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                              bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                              Maintenance requirements

                                              bull Up to 10 kg = 4cckghr

                                              bull 11-20kg = add 2cckghr

                                              bull 21kg and above = add 1cckghr

                                              bull Insensible losses = 2cckghr

                                              Surgical fluid losses

                                              Blood loss (measurement)

                                              1 Suction container

                                              2 Surgical sponge

                                              3 Hct and tachycardia not specific

                                              4 ABG and UO if hypoperfusion occur

                                              5 Blood loss=31 with crystalloid

                                              Other losses (third space loss)

                                              Third space loss

                                              1 Minimal (herniorrapy) =2-4cckghr

                                              2 Moderate (cholecystectomy)=4-6cckghr

                                              3 Severe (bowel resection) = 6-8cckghr

                                              Crystalloid solution

                                              1 The main solutions is either glucose or saline

                                              2 Hypotonic or isotonic or hypertonic

                                              3 Safe nontoxic reaction free inexpensive

                                              4 Complication is edema if large volumes are needed

                                              5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                              Colloids

                                              1 Albumin

                                              2 Hydroxyethyl starch

                                              3 Dextran

                                              Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                              factor )These colloid is best avoided in patients with

                                              coagulopaty

                                              The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                              1000cc

                                              500cc

                                              500cc

                                              500cc

                                              200

                                              600

                                              1000

                                              Lactated Ringers

                                              5 Albumin

                                              6 Hetastarch

                                              Whole blood

                                              Blood volumeInfusion volume

                                              Colloid versus crystalloid solutions

                                              Transfusion consideration

                                              bull HB lt7 mg dl increase CO

                                              bull Ideal Hb is 7-8 mgdl

                                              bull In IHD patients or pulmonary disease gt 10 mgdl

                                              بدن مایعات حجم در اختالل

                                              1 Fluid volume deficit

                                              2 Fluid volume excess

                                              Fluid volume deficit(FVD)

                                              ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                              کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                              ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                              باشد آن با همراه دیگری اختالل مگر

                                              DEHYDRATION

                                              سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                              سلولی خارج حجم کاهش علل

                                              1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                              2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                              کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                              Signs of HypovolemiaSigns of Hypovolemia

                                              bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                              Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                              bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                              Signs of HypervolemiaSigns of Hypervolemia

                                              bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                              Especially when hypo-albuminemia

                                              Management of Management of HypervolemiaHypervolemia

                                              bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                              Fluid ManagementFluid Management

                                              bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                              Electrolyte physiology

                                              Sodium physiology

                                              Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                              Normal amount 135-145 meql

                                              Osmotic Pressure

                                              Calculated serum osmolality =

                                              2 sodium+ glucose18 + BUN 28

                                              Osmolality = 290 mosm

                                              Concentration

                                              1Serum sodium concentration2Serum osmolarity

                                              bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                              drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                              DW5)

                                              Hypernatremia

                                              Serum Nagt145mEqL

                                              - Hypernatremia

                                              Loss of Free Water

                                              Gain of sodium in excess of water

                                              Hypernatremia

                                              -Hypernatremia Hypo volemic

                                              Hyper volemic

                                              Normo volemic

                                              Hypernatremia

                                              Volume Status

                                              Normal

                                              Nonrenal water loss

                                              Skin

                                              Gastrointestinal

                                              Renal water loss

                                              Renal disease

                                              Diuretics

                                              Diabetes insipidus

                                              High

                                              Iatrogenic sodium administration

                                              Mineralocorticoid excess

                                              Aldosteronism

                                              Cushingrsquos disease

                                              Congenital adrenal

                                              hyperplasia

                                              Low

                                              Nonrenal water loss

                                              Skin

                                              Gastrointestinal losses

                                              Renal water losses

                                              Renal (tubular) Diuretics

                                              Osmotic diuretics

                                              Diabetes insipidus

                                              Adrenal failure

                                              Asymptomatic

                                              Hypernatremia Symptomatic (Nagt160 meqL)

                                              Clinical Manifestations of Abnormalities in Serum Sodium

                                              Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                              Body system hypernatremia

                                              Treatment

                                              Normal saline in hypovolemic patients

                                              Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                              saline or entral water)

                                              Water deficit (L)= times TBW

                                              The formula used to estimate the amount of water required to correct hypernatremia

                                              Estimate TBW as 55 of lean body mass in men and 45 in women

                                              Serum sodium-140

                                              140

                                              The rate of fluid administration

                                              1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                              2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                              Hyponatremia Nalt135mEqL

                                              Causes

                                              1 Sodium depletion

                                              2 Sodium dilution

                                              bull Incidence = 45

                                              bull After surgery=1

                                              bull Mortality = 2 times normal

                                              Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                              volume deficit

                                              Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                              Sign and symptoms

                                              bull CNS symptom when Nalt123 meql

                                              bull Cardiac symptom when Nalt100 meql

                                              For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                              Body System Hyponatremia

                                              central nervous system Headache confusion hyper-or hypoactive deep tendon

                                              reflexes seizures coma increased intracranial pressure

                                              Musculoskeletal Weakness fatigue muscle crampstwitching

                                              Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                              Cardiovascular Hypertension and bradycardia if significant increases in

                                              intracranial pressure

                                              Tissue Lacrimation salivation

                                              Renal Oliguria

                                              Clinical Manifestations of Abnormalities in Serum Sodium

                                              Treatment

                                              1=Depend on ECF

                                              2=CNS sign

                                              Treatment

                                              1 Asymptomatic increase the sodium level by no more than

                                              05-1 meqLh to a maximum increase of 12 meqL per day

                                              2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                              more than 1meqL per hour until the serum Na level reaches 130

                                              meqL or neurologic symptoms are improved

                                              Rapid correction of hyponatremia

                                              Pontine myelinolysis

                                              Seizures weaknessparesis akinetic

                                              movements unresponsiveness

                                              Permanent brain damage

                                              Death

                                              Dose

                                              Na deficit meq =(140- Na meql) TBW

                                              باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                              شود اصالح آهسته سپس

                                              Potassium abnormalities

                                              bull The average dietary intake of potassium 50-100meqd

                                              bull The average renal excretion of potassium 10-700 meqd

                                              - 2 of the total body potassium in ECF (45meqL)

                                              - Factors that influence serum potassium

                                              1 Surgical stress

                                              2 Injury

                                              3 Acidosis

                                              4 Tissue catabolism

                                              Hyperkalemia

                                              The normal range of serum potassium 35-5 meqL

                                              Etiology of Hyperkalemia

                                              Increased intake Potassium supplementation

                                              Blood transfusions

                                              Endogenous loaddestruction

                                              hemolysis rhabdomyolysis

                                              cruch injury gastrointestinal hemorrhage

                                              Increased release Acidosis

                                              Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                              Renal insufficiencyfailure

                                              Clinical manifestation of hyperkalemia

                                              System hyperkalemia

                                              Gastrointestinal Nauseavomiting colic diarrhea

                                              Neuromuscular weakness paralysis respiratory failure

                                              Cardiovascular Arrhythmia arrest

                                              ECG changes Peaked T waves (early change)

                                              Flattened P wave

                                              Prolonged PR interval (first-degree block)

                                              Widened QRS complex

                                              Sine wave formation

                                              Ventricular fibrillation

                                              Treatment

                                              Treatment of symptomatic hyperkalemia

                                              Potassium removal Kayexalate

                                              Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                              Rectal administration is 50 g in 200 mL 20 sorbitol

                                              Dialysis

                                              Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                              Bicarbonate 1 vial intravenous

                                              Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                              HypokalemiaEtiology

                                              inadequate intake

                                              Dietary potassium-free intravenous fluids potassium-deficient

                                              total parenteral nutrition

                                              Excessive potassium excretion

                                              Hyperaldosteronism

                                              Medications

                                              Gastrointestinal losses

                                              Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                              Renal loss of potassium (gastric fluid either as vomiting or high

                                              nasogastric output)

                                              Intracellular-shift (metabolic alkalosis or insulin therapy)

                                              Potassium changes associated with alkalosis

                                              Potassium decrease by 03 meqL for every 01

                                              increase in PH above normal

                                              Magnesium Depletion

                                              (drug induced amphotericin amioglycosides cisplatin)

                                              Renal potassium wastage

                                              Hypokalemia

                                              Magnesium Depletion

                                              (drug induced amphotericin amioglycosides cisplatin)

                                              Renal potassium wastage

                                              Hypokalemia

                                              Clinical Manifestation of Abnormalities in potassium

                                              System hypokalemia

                                              Gastrointestinal Ileus constipation

                                              Neuromuscular Decreased reflexes fatigue weakness

                                              paralysis

                                              Cardiovascular Arrest

                                              ECG changes U-waves

                                              T-wave flattening

                                              ST-segment changes

                                              Arrhythmias

                                              Treatment

                                              Potassium

                                              Serum potassium level lt40 mEqL

                                              Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                              times 1 doses

                                              Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                              Symptomatic KC1 20 mEq IV q1h times 4 doses

                                              Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                              asymptomatic replace as per above protocol

                                              Electrolyte Replacement Therapy Protocol

                                              bull Oral repletion for mild and asymptomatic hypokalemia

                                              bull IV repletion for severe and symptomatic hypokalemia

                                              Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                              ( دندانها( ndash استخوانbull كلسيم نقش

                                              عصبي 1 ايمپالسهاي )NMJ(انتقال

                                              صاف 2 عضالت انقباض

                                              هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                              انعقاد 4

                                              یونیزه Calt45 meql هيپوكلسمي

                                              عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                              ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                              میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                              ( شود می پیوند شده

                                              هیپوکلسمی عالئم

                                              رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                              سایرعالئم

                                              قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                              درمان

                                              ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                              Cagt55meql هيپركلسمي

                                              هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                              عالئم

                                              bullGI

                                              bullCardiovascular bullRenal (polyuria)

                                              bullCNS

                                              قلبی عالئم

                                              bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                              QRS شدن )Q-Tوكوتاه

                                              درمان

                                              ایزوتونیک 1 نمکی محلول انفوزیون

                                              الزیکس2

                                              تونین 3 کلسی

                                              کورتون4

                                              دیالیز5

                                              Magnesium Abnormalities

                                              Normal dietary intake 20meq (240mg)

                                              Excretion in both the feces and urine

                                              Normal serum level 19-25 mgdL

                                              منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                              تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                              bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                              Hypermagnesemia

                                              Etiology

                                              1 Impaired renal function

                                              2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                              Clinical manifestation hypermanesemia

                                              System hypermanesemia

                                              Gastrointestinal Nauseavomiting

                                              Neuromuscular weakness lethargy Decreased

                                              reflexes

                                              Cardiovascular Hypotension arrest

                                              ECG changes Increased PR interval

                                              Widened QRS complex

                                              Elevated T waves

                                              Treatment

                                              1 Withhold exogenous sources of magnesium

                                              2 Correct volume deficit

                                              3 Correct acidosis if present

                                              4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                              5 Dialysis (if elevated levels or symptoms persist)

                                              عالئم

                                              bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                              meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                              meqL

                                              Hypomagnesemia

                                              Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                              homeostasis

                                              Etiology

                                              1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                              inadequate supplementation of magnesium)

                                              2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                              3 GI losses (diarrhea)

                                              4 Malabsorption

                                              5 Acute pancreatitis

                                              6 Diabetic ketoacidosis

                                              7 Primary aldosteronism

                                              Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                              1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                              2 Delirium and seizures in severe deficiency

                                              3 ECG changes Prolonged QT and PR interval

                                              ST-segment depression

                                              Flattening or inversion of P waves

                                              Torsades de pointes

                                              Arrhythmia

                                              Treatment

                                              1 For asymptomatic and mild hypomagnesemia administer oral mg

                                              2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                              Message for Today

                                              ICF

                                              Interstitial

                                              Pla

                                              sma

                                              5 Dex

                                              bull Do not reccussitate sick patients with any Dextrose solution

                                              • Fluid and Electrolyte Management of the Surgical Patient
                                              • Slide 2
                                              • Slide 3
                                              • Slide 4
                                              • Total Body Water
                                              • Body Fluid Compartments
                                              • Total body water (TBW)
                                              • Body compartment fluid
                                              • Example men with 70kg
                                              • Fluid compartments
                                              • Slide 11
                                              • Slide 12
                                              • Slide 13
                                              • Slide 14
                                              • Slide 15
                                              • Colloid osmotic pressure
                                              • Slide 17
                                              • Slide 18
                                              • Slide 19
                                              • Cell Membrane
                                              • Slide 21
                                              • Slide 22
                                              • Slide 23
                                              • Slide 24
                                              • Slide 25
                                              • Composition of Fluid Compartments
                                              • Composition of Body Fluids
                                              • عوامل موثر روی تغییرات آب والکترولیت
                                              • Reasons for fluid therapy
                                              • ارزیابی حجم مایع داخل عروقی
                                              • محلولهای وریدی
                                              • Fluids
                                              • Slide 33
                                              • Slide 34
                                              • Slide 35
                                              • Crystalloids
                                              • Colloid Solutions
                                              • رینگر لاکتات
                                              • 09Nacl
                                              • Postoperative (maintenance)
                                              • Slide 41
                                              • Preexisting fluid deficits
                                              • Maintenance requirements
                                              • Surgical fluid losses
                                              • Third space loss
                                              • Crystalloid solution
                                              • Colloids
                                              • Complications
                                              • The Influence of Colloid amp Crystalloid on Blood Volume
                                              • Colloid versus crystalloid solutions
                                              • Transfusion consideration
                                              • اختلال در حجم مایعات بدن
                                              • Fluid volume deficit (FVD)
                                              • DEHYDRATION
                                              • علل کاهش حجم خارج سلولی
                                              • Signs of Hypovolemia
                                              • Clinical Diagnosis of Hypovolemia
                                              • Signs of Hypervolemia
                                              • Management of Hypervolemia
                                              • Fluid Management
                                              • Electrolyte physiology
                                              • Sodium physiology
                                              • Osmotic Pressure
                                              • Concentration
                                              • Hypernatremia
                                              • - Hypernatremia
                                              • Slide 67
                                              • Slide 68
                                              • Clinical Manifestations of Abnormalities in Serum Sodium
                                              • Treatment
                                              • Water deficit (L)= times TBW
                                              • The rate of fluid administration
                                              • Hyponatremia Nalt135mEqL
                                              • Slide 74
                                              • Sodium depletion
                                              • Sodium dilution
                                              • Sign and symptoms
                                              • Slide 78
                                              • Treatment
                                              • Slide 80
                                              • Slide 81
                                              • Dose
                                              • Potassium abnormalities
                                              • Hyperkalemia
                                              • Clinical manifestation of hyperkalemia
                                              • Slide 86
                                              • Slide 87
                                              • Hypokalemia
                                              • Potassium changes associated with alkalosis
                                              • Slide 90
                                              • Clinical Manifestation of Abnormalities in potassium
                                              • Slide 92
                                              • Calcium
                                              • هيپوكلسمي یونیزه Calt45 meql
                                              • علائم هیپوکلسمی
                                              • Slide 96
                                              • Slide 97
                                              • Slide 98
                                              • Slide 99
                                              • سایرعلائم
                                              • درمان
                                              • هيپركلسمي Cagt55meql
                                              • علائم
                                              • علائم قلبی
                                              • Slide 105
                                              • Magnesium Abnormalities
                                              • منیزیوم
                                              • Hypermagnesemia
                                              • Clinical manifestation hypermanesemia
                                              • Slide 110
                                              • Slide 111
                                              • Hypomagnesemia
                                              • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                              • Slide 114
                                              • Message for Today
                                              • Slide 116

                                                Cell Membrane

                                                ICF

                                                Cell Membrane

                                                Na-

                                                K+

                                                Interstitial

                                                H2O

                                                H2O

                                                Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                                [K+] =4 [K+] =150

                                                Na+= 144

                                                Cell Membrane

                                                ICF

                                                Cell Membrane

                                                Na-

                                                K+

                                                Interstitial

                                                H2O

                                                H2O

                                                Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                                [K+] =4 [K+] =150

                                                Na+= 144Na+= 10

                                                Composition of Fluid Compartments

                                                CATIONS ANIONS

                                                Na+ 142 Cl - 103

                                                HC03- 27

                                                504mdash

                                                3 PO4

                                                ---

                                                K+ 4 organicCa++ 5 Acid 5

                                                Mg++ 3 Protein 16

                                                CATIONS ANIONS

                                                Na+ 144 Cl - 114

                                                HC03- 30

                                                504mdash

                                                K+ 4 3 PO4

                                                ---

                                                organic

                                                Ca++ 3 Acid 5

                                                Mg++ 2 Protein 1

                                                CATIONS ANIONS

                                                K+ 150 HPO4

                                                150 504

                                                mdash

                                                HCO3- 10

                                                Mg++ 40 Protein 40

                                                Na+ 10

                                                154 mEqL 153 mEqL 153 mEqL154 mEqL

                                                PLASMA INTERSTITAL FLID

                                                200 mEqL 200 mEqL

                                                INTRACELLULAR FLID

                                                Composition of Body FluidsComposition of Body Fluids

                                                Ca 2+

                                                Mg 2+

                                                K+

                                                Na+

                                                Cl-

                                                PO43-

                                                Organic anion

                                                HCO3-

                                                Protein

                                                0

                                                50

                                                50

                                                100

                                                150

                                                100

                                                150

                                                Cations Anions

                                                EC

                                                FICF

                                                Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                                                والکترولیت آب تغییرات روی موثر عوامل

                                                1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                                                عمل 2 از قبل والکترولیت آب وضعیت

                                                اندوکرینوپاتی )3 همراه )بیماریهای

                                                4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                                                Reasons for fluid therapyReasons for fluid therapy

                                                Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                                                bull Correct hypovolaemiaCorrect hypovolaemia

                                                bull Maintain cardiac outputMaintain cardiac output

                                                bull Optimise gas exchangeOptimise gas exchange

                                                bull Replace electrolytes amp waterReplace electrolytes amp water

                                                bull Maintain urine outputMaintain urine output

                                                Colloids + RBCs

                                                Crystalloids

                                                Identify what is the goal

                                                Choose fluid which best achieves the goal

                                                عروقی داخل مایع حجم ارزیابی

                                                بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                                                وریدی محلولهای

                                                Fluids bull Crystalloids

                                                bull Colloids

                                                bull blood

                                                Which of the following solutions is isotonic

                                                A D5W

                                                B 045 saline

                                                C 09 saline

                                                D D5 in 09 saline

                                                SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                                                ECFECF 142 4 5 103 27 280-310

                                                Lactated Lactated RingerrsquosRingerrsquos

                                                130 4 3 109 28 273

                                                09 NaCl09 NaCl 154 154 308

                                                045 045 NaClNaCl

                                                77 77 154

                                                D5WD5W

                                                D5045 D5045 NaClNaCl

                                                77 77 50 406

                                                3 NaCl3 NaCl 513 513 1026

                                                6 6 HetastarchHetastarch

                                                500 154 154 310

                                                5 5 AlbuminAlbumin

                                                250500130-160

                                                lt25130-160

                                                330

                                                25 25 AlbuminAlbumin

                                                2050100130-160

                                                lt25130-160

                                                330

                                                Common parenteral fluid therapyCommon parenteral fluid therapy

                                                CrystalloidsCrystalloids

                                                bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                                Colloid SolutionsColloid Solutions

                                                bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                                - Haes-steril 10

                                                الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                                کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                                ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                                osm=273

                                                09Nacl

                                                bull Na=154

                                                bull CL= 154

                                                کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                                PH=56است

                                                Postoperative (maintenance)

                                                045Nacl +5 dextrose +KCL

                                                Perioperative management of fluid balance include

                                                1 Preoperative evaluation

                                                2 Intraoperative maintenance

                                                3 Replacement of fluid losses

                                                Preexisting fluid deficits

                                                bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                                bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                                Maintenance requirements

                                                bull Up to 10 kg = 4cckghr

                                                bull 11-20kg = add 2cckghr

                                                bull 21kg and above = add 1cckghr

                                                bull Insensible losses = 2cckghr

                                                Surgical fluid losses

                                                Blood loss (measurement)

                                                1 Suction container

                                                2 Surgical sponge

                                                3 Hct and tachycardia not specific

                                                4 ABG and UO if hypoperfusion occur

                                                5 Blood loss=31 with crystalloid

                                                Other losses (third space loss)

                                                Third space loss

                                                1 Minimal (herniorrapy) =2-4cckghr

                                                2 Moderate (cholecystectomy)=4-6cckghr

                                                3 Severe (bowel resection) = 6-8cckghr

                                                Crystalloid solution

                                                1 The main solutions is either glucose or saline

                                                2 Hypotonic or isotonic or hypertonic

                                                3 Safe nontoxic reaction free inexpensive

                                                4 Complication is edema if large volumes are needed

                                                5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                Colloids

                                                1 Albumin

                                                2 Hydroxyethyl starch

                                                3 Dextran

                                                Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                factor )These colloid is best avoided in patients with

                                                coagulopaty

                                                The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                1000cc

                                                500cc

                                                500cc

                                                500cc

                                                200

                                                600

                                                1000

                                                Lactated Ringers

                                                5 Albumin

                                                6 Hetastarch

                                                Whole blood

                                                Blood volumeInfusion volume

                                                Colloid versus crystalloid solutions

                                                Transfusion consideration

                                                bull HB lt7 mg dl increase CO

                                                bull Ideal Hb is 7-8 mgdl

                                                bull In IHD patients or pulmonary disease gt 10 mgdl

                                                بدن مایعات حجم در اختالل

                                                1 Fluid volume deficit

                                                2 Fluid volume excess

                                                Fluid volume deficit(FVD)

                                                ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                باشد آن با همراه دیگری اختالل مگر

                                                DEHYDRATION

                                                سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                سلولی خارج حجم کاهش علل

                                                1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                Signs of HypovolemiaSigns of Hypovolemia

                                                bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                Signs of HypervolemiaSigns of Hypervolemia

                                                bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                Especially when hypo-albuminemia

                                                Management of Management of HypervolemiaHypervolemia

                                                bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                Fluid ManagementFluid Management

                                                bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                Electrolyte physiology

                                                Sodium physiology

                                                Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                Normal amount 135-145 meql

                                                Osmotic Pressure

                                                Calculated serum osmolality =

                                                2 sodium+ glucose18 + BUN 28

                                                Osmolality = 290 mosm

                                                Concentration

                                                1Serum sodium concentration2Serum osmolarity

                                                bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                DW5)

                                                Hypernatremia

                                                Serum Nagt145mEqL

                                                - Hypernatremia

                                                Loss of Free Water

                                                Gain of sodium in excess of water

                                                Hypernatremia

                                                -Hypernatremia Hypo volemic

                                                Hyper volemic

                                                Normo volemic

                                                Hypernatremia

                                                Volume Status

                                                Normal

                                                Nonrenal water loss

                                                Skin

                                                Gastrointestinal

                                                Renal water loss

                                                Renal disease

                                                Diuretics

                                                Diabetes insipidus

                                                High

                                                Iatrogenic sodium administration

                                                Mineralocorticoid excess

                                                Aldosteronism

                                                Cushingrsquos disease

                                                Congenital adrenal

                                                hyperplasia

                                                Low

                                                Nonrenal water loss

                                                Skin

                                                Gastrointestinal losses

                                                Renal water losses

                                                Renal (tubular) Diuretics

                                                Osmotic diuretics

                                                Diabetes insipidus

                                                Adrenal failure

                                                Asymptomatic

                                                Hypernatremia Symptomatic (Nagt160 meqL)

                                                Clinical Manifestations of Abnormalities in Serum Sodium

                                                Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                Body system hypernatremia

                                                Treatment

                                                Normal saline in hypovolemic patients

                                                Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                saline or entral water)

                                                Water deficit (L)= times TBW

                                                The formula used to estimate the amount of water required to correct hypernatremia

                                                Estimate TBW as 55 of lean body mass in men and 45 in women

                                                Serum sodium-140

                                                140

                                                The rate of fluid administration

                                                1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                Hyponatremia Nalt135mEqL

                                                Causes

                                                1 Sodium depletion

                                                2 Sodium dilution

                                                bull Incidence = 45

                                                bull After surgery=1

                                                bull Mortality = 2 times normal

                                                Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                volume deficit

                                                Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                Sign and symptoms

                                                bull CNS symptom when Nalt123 meql

                                                bull Cardiac symptom when Nalt100 meql

                                                For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                Body System Hyponatremia

                                                central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                reflexes seizures coma increased intracranial pressure

                                                Musculoskeletal Weakness fatigue muscle crampstwitching

                                                Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                Cardiovascular Hypertension and bradycardia if significant increases in

                                                intracranial pressure

                                                Tissue Lacrimation salivation

                                                Renal Oliguria

                                                Clinical Manifestations of Abnormalities in Serum Sodium

                                                Treatment

                                                1=Depend on ECF

                                                2=CNS sign

                                                Treatment

                                                1 Asymptomatic increase the sodium level by no more than

                                                05-1 meqLh to a maximum increase of 12 meqL per day

                                                2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                more than 1meqL per hour until the serum Na level reaches 130

                                                meqL or neurologic symptoms are improved

                                                Rapid correction of hyponatremia

                                                Pontine myelinolysis

                                                Seizures weaknessparesis akinetic

                                                movements unresponsiveness

                                                Permanent brain damage

                                                Death

                                                Dose

                                                Na deficit meq =(140- Na meql) TBW

                                                باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                شود اصالح آهسته سپس

                                                Potassium abnormalities

                                                bull The average dietary intake of potassium 50-100meqd

                                                bull The average renal excretion of potassium 10-700 meqd

                                                - 2 of the total body potassium in ECF (45meqL)

                                                - Factors that influence serum potassium

                                                1 Surgical stress

                                                2 Injury

                                                3 Acidosis

                                                4 Tissue catabolism

                                                Hyperkalemia

                                                The normal range of serum potassium 35-5 meqL

                                                Etiology of Hyperkalemia

                                                Increased intake Potassium supplementation

                                                Blood transfusions

                                                Endogenous loaddestruction

                                                hemolysis rhabdomyolysis

                                                cruch injury gastrointestinal hemorrhage

                                                Increased release Acidosis

                                                Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                Renal insufficiencyfailure

                                                Clinical manifestation of hyperkalemia

                                                System hyperkalemia

                                                Gastrointestinal Nauseavomiting colic diarrhea

                                                Neuromuscular weakness paralysis respiratory failure

                                                Cardiovascular Arrhythmia arrest

                                                ECG changes Peaked T waves (early change)

                                                Flattened P wave

                                                Prolonged PR interval (first-degree block)

                                                Widened QRS complex

                                                Sine wave formation

                                                Ventricular fibrillation

                                                Treatment

                                                Treatment of symptomatic hyperkalemia

                                                Potassium removal Kayexalate

                                                Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                Rectal administration is 50 g in 200 mL 20 sorbitol

                                                Dialysis

                                                Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                Bicarbonate 1 vial intravenous

                                                Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                HypokalemiaEtiology

                                                inadequate intake

                                                Dietary potassium-free intravenous fluids potassium-deficient

                                                total parenteral nutrition

                                                Excessive potassium excretion

                                                Hyperaldosteronism

                                                Medications

                                                Gastrointestinal losses

                                                Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                Renal loss of potassium (gastric fluid either as vomiting or high

                                                nasogastric output)

                                                Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                Potassium changes associated with alkalosis

                                                Potassium decrease by 03 meqL for every 01

                                                increase in PH above normal

                                                Magnesium Depletion

                                                (drug induced amphotericin amioglycosides cisplatin)

                                                Renal potassium wastage

                                                Hypokalemia

                                                Magnesium Depletion

                                                (drug induced amphotericin amioglycosides cisplatin)

                                                Renal potassium wastage

                                                Hypokalemia

                                                Clinical Manifestation of Abnormalities in potassium

                                                System hypokalemia

                                                Gastrointestinal Ileus constipation

                                                Neuromuscular Decreased reflexes fatigue weakness

                                                paralysis

                                                Cardiovascular Arrest

                                                ECG changes U-waves

                                                T-wave flattening

                                                ST-segment changes

                                                Arrhythmias

                                                Treatment

                                                Potassium

                                                Serum potassium level lt40 mEqL

                                                Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                times 1 doses

                                                Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                asymptomatic replace as per above protocol

                                                Electrolyte Replacement Therapy Protocol

                                                bull Oral repletion for mild and asymptomatic hypokalemia

                                                bull IV repletion for severe and symptomatic hypokalemia

                                                Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                ( دندانها( ndash استخوانbull كلسيم نقش

                                                عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                صاف 2 عضالت انقباض

                                                هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                انعقاد 4

                                                یونیزه Calt45 meql هيپوكلسمي

                                                عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                ( شود می پیوند شده

                                                هیپوکلسمی عالئم

                                                رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                سایرعالئم

                                                قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                درمان

                                                ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                Cagt55meql هيپركلسمي

                                                هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                عالئم

                                                bullGI

                                                bullCardiovascular bullRenal (polyuria)

                                                bullCNS

                                                قلبی عالئم

                                                bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                QRS شدن )Q-Tوكوتاه

                                                درمان

                                                ایزوتونیک 1 نمکی محلول انفوزیون

                                                الزیکس2

                                                تونین 3 کلسی

                                                کورتون4

                                                دیالیز5

                                                Magnesium Abnormalities

                                                Normal dietary intake 20meq (240mg)

                                                Excretion in both the feces and urine

                                                Normal serum level 19-25 mgdL

                                                منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                Hypermagnesemia

                                                Etiology

                                                1 Impaired renal function

                                                2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                Clinical manifestation hypermanesemia

                                                System hypermanesemia

                                                Gastrointestinal Nauseavomiting

                                                Neuromuscular weakness lethargy Decreased

                                                reflexes

                                                Cardiovascular Hypotension arrest

                                                ECG changes Increased PR interval

                                                Widened QRS complex

                                                Elevated T waves

                                                Treatment

                                                1 Withhold exogenous sources of magnesium

                                                2 Correct volume deficit

                                                3 Correct acidosis if present

                                                4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                5 Dialysis (if elevated levels or symptoms persist)

                                                عالئم

                                                bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                meqL

                                                Hypomagnesemia

                                                Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                homeostasis

                                                Etiology

                                                1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                inadequate supplementation of magnesium)

                                                2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                3 GI losses (diarrhea)

                                                4 Malabsorption

                                                5 Acute pancreatitis

                                                6 Diabetic ketoacidosis

                                                7 Primary aldosteronism

                                                Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                2 Delirium and seizures in severe deficiency

                                                3 ECG changes Prolonged QT and PR interval

                                                ST-segment depression

                                                Flattening or inversion of P waves

                                                Torsades de pointes

                                                Arrhythmia

                                                Treatment

                                                1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                Message for Today

                                                ICF

                                                Interstitial

                                                Pla

                                                sma

                                                5 Dex

                                                bull Do not reccussitate sick patients with any Dextrose solution

                                                • Fluid and Electrolyte Management of the Surgical Patient
                                                • Slide 2
                                                • Slide 3
                                                • Slide 4
                                                • Total Body Water
                                                • Body Fluid Compartments
                                                • Total body water (TBW)
                                                • Body compartment fluid
                                                • Example men with 70kg
                                                • Fluid compartments
                                                • Slide 11
                                                • Slide 12
                                                • Slide 13
                                                • Slide 14
                                                • Slide 15
                                                • Colloid osmotic pressure
                                                • Slide 17
                                                • Slide 18
                                                • Slide 19
                                                • Cell Membrane
                                                • Slide 21
                                                • Slide 22
                                                • Slide 23
                                                • Slide 24
                                                • Slide 25
                                                • Composition of Fluid Compartments
                                                • Composition of Body Fluids
                                                • عوامل موثر روی تغییرات آب والکترولیت
                                                • Reasons for fluid therapy
                                                • ارزیابی حجم مایع داخل عروقی
                                                • محلولهای وریدی
                                                • Fluids
                                                • Slide 33
                                                • Slide 34
                                                • Slide 35
                                                • Crystalloids
                                                • Colloid Solutions
                                                • رینگر لاکتات
                                                • 09Nacl
                                                • Postoperative (maintenance)
                                                • Slide 41
                                                • Preexisting fluid deficits
                                                • Maintenance requirements
                                                • Surgical fluid losses
                                                • Third space loss
                                                • Crystalloid solution
                                                • Colloids
                                                • Complications
                                                • The Influence of Colloid amp Crystalloid on Blood Volume
                                                • Colloid versus crystalloid solutions
                                                • Transfusion consideration
                                                • اختلال در حجم مایعات بدن
                                                • Fluid volume deficit (FVD)
                                                • DEHYDRATION
                                                • علل کاهش حجم خارج سلولی
                                                • Signs of Hypovolemia
                                                • Clinical Diagnosis of Hypovolemia
                                                • Signs of Hypervolemia
                                                • Management of Hypervolemia
                                                • Fluid Management
                                                • Electrolyte physiology
                                                • Sodium physiology
                                                • Osmotic Pressure
                                                • Concentration
                                                • Hypernatremia
                                                • - Hypernatremia
                                                • Slide 67
                                                • Slide 68
                                                • Clinical Manifestations of Abnormalities in Serum Sodium
                                                • Treatment
                                                • Water deficit (L)= times TBW
                                                • The rate of fluid administration
                                                • Hyponatremia Nalt135mEqL
                                                • Slide 74
                                                • Sodium depletion
                                                • Sodium dilution
                                                • Sign and symptoms
                                                • Slide 78
                                                • Treatment
                                                • Slide 80
                                                • Slide 81
                                                • Dose
                                                • Potassium abnormalities
                                                • Hyperkalemia
                                                • Clinical manifestation of hyperkalemia
                                                • Slide 86
                                                • Slide 87
                                                • Hypokalemia
                                                • Potassium changes associated with alkalosis
                                                • Slide 90
                                                • Clinical Manifestation of Abnormalities in potassium
                                                • Slide 92
                                                • Calcium
                                                • هيپوكلسمي یونیزه Calt45 meql
                                                • علائم هیپوکلسمی
                                                • Slide 96
                                                • Slide 97
                                                • Slide 98
                                                • Slide 99
                                                • سایرعلائم
                                                • درمان
                                                • هيپركلسمي Cagt55meql
                                                • علائم
                                                • علائم قلبی
                                                • Slide 105
                                                • Magnesium Abnormalities
                                                • منیزیوم
                                                • Hypermagnesemia
                                                • Clinical manifestation hypermanesemia
                                                • Slide 110
                                                • Slide 111
                                                • Hypomagnesemia
                                                • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                • Slide 114
                                                • Message for Today
                                                • Slide 116

                                                  Cell Membrane

                                                  ICF

                                                  Cell Membrane

                                                  Na-

                                                  K+

                                                  Interstitial

                                                  H2O

                                                  H2O

                                                  Cell membrane is freely permeable to H20 but Na and K are pumped across this membrane to maintain a gradient

                                                  [K+] =4 [K+] =150

                                                  Na+= 144Na+= 10

                                                  Composition of Fluid Compartments

                                                  CATIONS ANIONS

                                                  Na+ 142 Cl - 103

                                                  HC03- 27

                                                  504mdash

                                                  3 PO4

                                                  ---

                                                  K+ 4 organicCa++ 5 Acid 5

                                                  Mg++ 3 Protein 16

                                                  CATIONS ANIONS

                                                  Na+ 144 Cl - 114

                                                  HC03- 30

                                                  504mdash

                                                  K+ 4 3 PO4

                                                  ---

                                                  organic

                                                  Ca++ 3 Acid 5

                                                  Mg++ 2 Protein 1

                                                  CATIONS ANIONS

                                                  K+ 150 HPO4

                                                  150 504

                                                  mdash

                                                  HCO3- 10

                                                  Mg++ 40 Protein 40

                                                  Na+ 10

                                                  154 mEqL 153 mEqL 153 mEqL154 mEqL

                                                  PLASMA INTERSTITAL FLID

                                                  200 mEqL 200 mEqL

                                                  INTRACELLULAR FLID

                                                  Composition of Body FluidsComposition of Body Fluids

                                                  Ca 2+

                                                  Mg 2+

                                                  K+

                                                  Na+

                                                  Cl-

                                                  PO43-

                                                  Organic anion

                                                  HCO3-

                                                  Protein

                                                  0

                                                  50

                                                  50

                                                  100

                                                  150

                                                  100

                                                  150

                                                  Cations Anions

                                                  EC

                                                  FICF

                                                  Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                                                  والکترولیت آب تغییرات روی موثر عوامل

                                                  1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                                                  عمل 2 از قبل والکترولیت آب وضعیت

                                                  اندوکرینوپاتی )3 همراه )بیماریهای

                                                  4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                                                  Reasons for fluid therapyReasons for fluid therapy

                                                  Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                                                  bull Correct hypovolaemiaCorrect hypovolaemia

                                                  bull Maintain cardiac outputMaintain cardiac output

                                                  bull Optimise gas exchangeOptimise gas exchange

                                                  bull Replace electrolytes amp waterReplace electrolytes amp water

                                                  bull Maintain urine outputMaintain urine output

                                                  Colloids + RBCs

                                                  Crystalloids

                                                  Identify what is the goal

                                                  Choose fluid which best achieves the goal

                                                  عروقی داخل مایع حجم ارزیابی

                                                  بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                                                  وریدی محلولهای

                                                  Fluids bull Crystalloids

                                                  bull Colloids

                                                  bull blood

                                                  Which of the following solutions is isotonic

                                                  A D5W

                                                  B 045 saline

                                                  C 09 saline

                                                  D D5 in 09 saline

                                                  SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                                                  ECFECF 142 4 5 103 27 280-310

                                                  Lactated Lactated RingerrsquosRingerrsquos

                                                  130 4 3 109 28 273

                                                  09 NaCl09 NaCl 154 154 308

                                                  045 045 NaClNaCl

                                                  77 77 154

                                                  D5WD5W

                                                  D5045 D5045 NaClNaCl

                                                  77 77 50 406

                                                  3 NaCl3 NaCl 513 513 1026

                                                  6 6 HetastarchHetastarch

                                                  500 154 154 310

                                                  5 5 AlbuminAlbumin

                                                  250500130-160

                                                  lt25130-160

                                                  330

                                                  25 25 AlbuminAlbumin

                                                  2050100130-160

                                                  lt25130-160

                                                  330

                                                  Common parenteral fluid therapyCommon parenteral fluid therapy

                                                  CrystalloidsCrystalloids

                                                  bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                                  Colloid SolutionsColloid Solutions

                                                  bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                                  - Haes-steril 10

                                                  الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                                  کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                                  ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                                  osm=273

                                                  09Nacl

                                                  bull Na=154

                                                  bull CL= 154

                                                  کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                                  PH=56است

                                                  Postoperative (maintenance)

                                                  045Nacl +5 dextrose +KCL

                                                  Perioperative management of fluid balance include

                                                  1 Preoperative evaluation

                                                  2 Intraoperative maintenance

                                                  3 Replacement of fluid losses

                                                  Preexisting fluid deficits

                                                  bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                                  bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                                  Maintenance requirements

                                                  bull Up to 10 kg = 4cckghr

                                                  bull 11-20kg = add 2cckghr

                                                  bull 21kg and above = add 1cckghr

                                                  bull Insensible losses = 2cckghr

                                                  Surgical fluid losses

                                                  Blood loss (measurement)

                                                  1 Suction container

                                                  2 Surgical sponge

                                                  3 Hct and tachycardia not specific

                                                  4 ABG and UO if hypoperfusion occur

                                                  5 Blood loss=31 with crystalloid

                                                  Other losses (third space loss)

                                                  Third space loss

                                                  1 Minimal (herniorrapy) =2-4cckghr

                                                  2 Moderate (cholecystectomy)=4-6cckghr

                                                  3 Severe (bowel resection) = 6-8cckghr

                                                  Crystalloid solution

                                                  1 The main solutions is either glucose or saline

                                                  2 Hypotonic or isotonic or hypertonic

                                                  3 Safe nontoxic reaction free inexpensive

                                                  4 Complication is edema if large volumes are needed

                                                  5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                  Colloids

                                                  1 Albumin

                                                  2 Hydroxyethyl starch

                                                  3 Dextran

                                                  Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                  factor )These colloid is best avoided in patients with

                                                  coagulopaty

                                                  The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                  1000cc

                                                  500cc

                                                  500cc

                                                  500cc

                                                  200

                                                  600

                                                  1000

                                                  Lactated Ringers

                                                  5 Albumin

                                                  6 Hetastarch

                                                  Whole blood

                                                  Blood volumeInfusion volume

                                                  Colloid versus crystalloid solutions

                                                  Transfusion consideration

                                                  bull HB lt7 mg dl increase CO

                                                  bull Ideal Hb is 7-8 mgdl

                                                  bull In IHD patients or pulmonary disease gt 10 mgdl

                                                  بدن مایعات حجم در اختالل

                                                  1 Fluid volume deficit

                                                  2 Fluid volume excess

                                                  Fluid volume deficit(FVD)

                                                  ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                  کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                  ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                  باشد آن با همراه دیگری اختالل مگر

                                                  DEHYDRATION

                                                  سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                  سلولی خارج حجم کاهش علل

                                                  1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                  2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                  کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                  Signs of HypovolemiaSigns of Hypovolemia

                                                  bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                  Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                  bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                  Signs of HypervolemiaSigns of Hypervolemia

                                                  bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                  Especially when hypo-albuminemia

                                                  Management of Management of HypervolemiaHypervolemia

                                                  bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                  Fluid ManagementFluid Management

                                                  bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                  Electrolyte physiology

                                                  Sodium physiology

                                                  Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                  Normal amount 135-145 meql

                                                  Osmotic Pressure

                                                  Calculated serum osmolality =

                                                  2 sodium+ glucose18 + BUN 28

                                                  Osmolality = 290 mosm

                                                  Concentration

                                                  1Serum sodium concentration2Serum osmolarity

                                                  bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                  drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                  DW5)

                                                  Hypernatremia

                                                  Serum Nagt145mEqL

                                                  - Hypernatremia

                                                  Loss of Free Water

                                                  Gain of sodium in excess of water

                                                  Hypernatremia

                                                  -Hypernatremia Hypo volemic

                                                  Hyper volemic

                                                  Normo volemic

                                                  Hypernatremia

                                                  Volume Status

                                                  Normal

                                                  Nonrenal water loss

                                                  Skin

                                                  Gastrointestinal

                                                  Renal water loss

                                                  Renal disease

                                                  Diuretics

                                                  Diabetes insipidus

                                                  High

                                                  Iatrogenic sodium administration

                                                  Mineralocorticoid excess

                                                  Aldosteronism

                                                  Cushingrsquos disease

                                                  Congenital adrenal

                                                  hyperplasia

                                                  Low

                                                  Nonrenal water loss

                                                  Skin

                                                  Gastrointestinal losses

                                                  Renal water losses

                                                  Renal (tubular) Diuretics

                                                  Osmotic diuretics

                                                  Diabetes insipidus

                                                  Adrenal failure

                                                  Asymptomatic

                                                  Hypernatremia Symptomatic (Nagt160 meqL)

                                                  Clinical Manifestations of Abnormalities in Serum Sodium

                                                  Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                  Body system hypernatremia

                                                  Treatment

                                                  Normal saline in hypovolemic patients

                                                  Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                  saline or entral water)

                                                  Water deficit (L)= times TBW

                                                  The formula used to estimate the amount of water required to correct hypernatremia

                                                  Estimate TBW as 55 of lean body mass in men and 45 in women

                                                  Serum sodium-140

                                                  140

                                                  The rate of fluid administration

                                                  1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                  2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                  Hyponatremia Nalt135mEqL

                                                  Causes

                                                  1 Sodium depletion

                                                  2 Sodium dilution

                                                  bull Incidence = 45

                                                  bull After surgery=1

                                                  bull Mortality = 2 times normal

                                                  Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                  volume deficit

                                                  Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                  Sign and symptoms

                                                  bull CNS symptom when Nalt123 meql

                                                  bull Cardiac symptom when Nalt100 meql

                                                  For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                  Body System Hyponatremia

                                                  central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                  reflexes seizures coma increased intracranial pressure

                                                  Musculoskeletal Weakness fatigue muscle crampstwitching

                                                  Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                  Cardiovascular Hypertension and bradycardia if significant increases in

                                                  intracranial pressure

                                                  Tissue Lacrimation salivation

                                                  Renal Oliguria

                                                  Clinical Manifestations of Abnormalities in Serum Sodium

                                                  Treatment

                                                  1=Depend on ECF

                                                  2=CNS sign

                                                  Treatment

                                                  1 Asymptomatic increase the sodium level by no more than

                                                  05-1 meqLh to a maximum increase of 12 meqL per day

                                                  2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                  more than 1meqL per hour until the serum Na level reaches 130

                                                  meqL or neurologic symptoms are improved

                                                  Rapid correction of hyponatremia

                                                  Pontine myelinolysis

                                                  Seizures weaknessparesis akinetic

                                                  movements unresponsiveness

                                                  Permanent brain damage

                                                  Death

                                                  Dose

                                                  Na deficit meq =(140- Na meql) TBW

                                                  باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                  شود اصالح آهسته سپس

                                                  Potassium abnormalities

                                                  bull The average dietary intake of potassium 50-100meqd

                                                  bull The average renal excretion of potassium 10-700 meqd

                                                  - 2 of the total body potassium in ECF (45meqL)

                                                  - Factors that influence serum potassium

                                                  1 Surgical stress

                                                  2 Injury

                                                  3 Acidosis

                                                  4 Tissue catabolism

                                                  Hyperkalemia

                                                  The normal range of serum potassium 35-5 meqL

                                                  Etiology of Hyperkalemia

                                                  Increased intake Potassium supplementation

                                                  Blood transfusions

                                                  Endogenous loaddestruction

                                                  hemolysis rhabdomyolysis

                                                  cruch injury gastrointestinal hemorrhage

                                                  Increased release Acidosis

                                                  Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                  Renal insufficiencyfailure

                                                  Clinical manifestation of hyperkalemia

                                                  System hyperkalemia

                                                  Gastrointestinal Nauseavomiting colic diarrhea

                                                  Neuromuscular weakness paralysis respiratory failure

                                                  Cardiovascular Arrhythmia arrest

                                                  ECG changes Peaked T waves (early change)

                                                  Flattened P wave

                                                  Prolonged PR interval (first-degree block)

                                                  Widened QRS complex

                                                  Sine wave formation

                                                  Ventricular fibrillation

                                                  Treatment

                                                  Treatment of symptomatic hyperkalemia

                                                  Potassium removal Kayexalate

                                                  Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                  Rectal administration is 50 g in 200 mL 20 sorbitol

                                                  Dialysis

                                                  Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                  Bicarbonate 1 vial intravenous

                                                  Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                  HypokalemiaEtiology

                                                  inadequate intake

                                                  Dietary potassium-free intravenous fluids potassium-deficient

                                                  total parenteral nutrition

                                                  Excessive potassium excretion

                                                  Hyperaldosteronism

                                                  Medications

                                                  Gastrointestinal losses

                                                  Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                  Renal loss of potassium (gastric fluid either as vomiting or high

                                                  nasogastric output)

                                                  Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                  Potassium changes associated with alkalosis

                                                  Potassium decrease by 03 meqL for every 01

                                                  increase in PH above normal

                                                  Magnesium Depletion

                                                  (drug induced amphotericin amioglycosides cisplatin)

                                                  Renal potassium wastage

                                                  Hypokalemia

                                                  Magnesium Depletion

                                                  (drug induced amphotericin amioglycosides cisplatin)

                                                  Renal potassium wastage

                                                  Hypokalemia

                                                  Clinical Manifestation of Abnormalities in potassium

                                                  System hypokalemia

                                                  Gastrointestinal Ileus constipation

                                                  Neuromuscular Decreased reflexes fatigue weakness

                                                  paralysis

                                                  Cardiovascular Arrest

                                                  ECG changes U-waves

                                                  T-wave flattening

                                                  ST-segment changes

                                                  Arrhythmias

                                                  Treatment

                                                  Potassium

                                                  Serum potassium level lt40 mEqL

                                                  Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                  times 1 doses

                                                  Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                  Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                  Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                  asymptomatic replace as per above protocol

                                                  Electrolyte Replacement Therapy Protocol

                                                  bull Oral repletion for mild and asymptomatic hypokalemia

                                                  bull IV repletion for severe and symptomatic hypokalemia

                                                  Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                  ( دندانها( ndash استخوانbull كلسيم نقش

                                                  عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                  صاف 2 عضالت انقباض

                                                  هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                  انعقاد 4

                                                  یونیزه Calt45 meql هيپوكلسمي

                                                  عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                  ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                  میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                  ( شود می پیوند شده

                                                  هیپوکلسمی عالئم

                                                  رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                  سایرعالئم

                                                  قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                  درمان

                                                  ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                  Cagt55meql هيپركلسمي

                                                  هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                  عالئم

                                                  bullGI

                                                  bullCardiovascular bullRenal (polyuria)

                                                  bullCNS

                                                  قلبی عالئم

                                                  bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                  QRS شدن )Q-Tوكوتاه

                                                  درمان

                                                  ایزوتونیک 1 نمکی محلول انفوزیون

                                                  الزیکس2

                                                  تونین 3 کلسی

                                                  کورتون4

                                                  دیالیز5

                                                  Magnesium Abnormalities

                                                  Normal dietary intake 20meq (240mg)

                                                  Excretion in both the feces and urine

                                                  Normal serum level 19-25 mgdL

                                                  منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                  تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                  bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                  Hypermagnesemia

                                                  Etiology

                                                  1 Impaired renal function

                                                  2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                  Clinical manifestation hypermanesemia

                                                  System hypermanesemia

                                                  Gastrointestinal Nauseavomiting

                                                  Neuromuscular weakness lethargy Decreased

                                                  reflexes

                                                  Cardiovascular Hypotension arrest

                                                  ECG changes Increased PR interval

                                                  Widened QRS complex

                                                  Elevated T waves

                                                  Treatment

                                                  1 Withhold exogenous sources of magnesium

                                                  2 Correct volume deficit

                                                  3 Correct acidosis if present

                                                  4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                  5 Dialysis (if elevated levels or symptoms persist)

                                                  عالئم

                                                  bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                  meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                  meqL

                                                  Hypomagnesemia

                                                  Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                  homeostasis

                                                  Etiology

                                                  1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                  inadequate supplementation of magnesium)

                                                  2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                  3 GI losses (diarrhea)

                                                  4 Malabsorption

                                                  5 Acute pancreatitis

                                                  6 Diabetic ketoacidosis

                                                  7 Primary aldosteronism

                                                  Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                  1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                  2 Delirium and seizures in severe deficiency

                                                  3 ECG changes Prolonged QT and PR interval

                                                  ST-segment depression

                                                  Flattening or inversion of P waves

                                                  Torsades de pointes

                                                  Arrhythmia

                                                  Treatment

                                                  1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                  2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                  Message for Today

                                                  ICF

                                                  Interstitial

                                                  Pla

                                                  sma

                                                  5 Dex

                                                  bull Do not reccussitate sick patients with any Dextrose solution

                                                  • Fluid and Electrolyte Management of the Surgical Patient
                                                  • Slide 2
                                                  • Slide 3
                                                  • Slide 4
                                                  • Total Body Water
                                                  • Body Fluid Compartments
                                                  • Total body water (TBW)
                                                  • Body compartment fluid
                                                  • Example men with 70kg
                                                  • Fluid compartments
                                                  • Slide 11
                                                  • Slide 12
                                                  • Slide 13
                                                  • Slide 14
                                                  • Slide 15
                                                  • Colloid osmotic pressure
                                                  • Slide 17
                                                  • Slide 18
                                                  • Slide 19
                                                  • Cell Membrane
                                                  • Slide 21
                                                  • Slide 22
                                                  • Slide 23
                                                  • Slide 24
                                                  • Slide 25
                                                  • Composition of Fluid Compartments
                                                  • Composition of Body Fluids
                                                  • عوامل موثر روی تغییرات آب والکترولیت
                                                  • Reasons for fluid therapy
                                                  • ارزیابی حجم مایع داخل عروقی
                                                  • محلولهای وریدی
                                                  • Fluids
                                                  • Slide 33
                                                  • Slide 34
                                                  • Slide 35
                                                  • Crystalloids
                                                  • Colloid Solutions
                                                  • رینگر لاکتات
                                                  • 09Nacl
                                                  • Postoperative (maintenance)
                                                  • Slide 41
                                                  • Preexisting fluid deficits
                                                  • Maintenance requirements
                                                  • Surgical fluid losses
                                                  • Third space loss
                                                  • Crystalloid solution
                                                  • Colloids
                                                  • Complications
                                                  • The Influence of Colloid amp Crystalloid on Blood Volume
                                                  • Colloid versus crystalloid solutions
                                                  • Transfusion consideration
                                                  • اختلال در حجم مایعات بدن
                                                  • Fluid volume deficit (FVD)
                                                  • DEHYDRATION
                                                  • علل کاهش حجم خارج سلولی
                                                  • Signs of Hypovolemia
                                                  • Clinical Diagnosis of Hypovolemia
                                                  • Signs of Hypervolemia
                                                  • Management of Hypervolemia
                                                  • Fluid Management
                                                  • Electrolyte physiology
                                                  • Sodium physiology
                                                  • Osmotic Pressure
                                                  • Concentration
                                                  • Hypernatremia
                                                  • - Hypernatremia
                                                  • Slide 67
                                                  • Slide 68
                                                  • Clinical Manifestations of Abnormalities in Serum Sodium
                                                  • Treatment
                                                  • Water deficit (L)= times TBW
                                                  • The rate of fluid administration
                                                  • Hyponatremia Nalt135mEqL
                                                  • Slide 74
                                                  • Sodium depletion
                                                  • Sodium dilution
                                                  • Sign and symptoms
                                                  • Slide 78
                                                  • Treatment
                                                  • Slide 80
                                                  • Slide 81
                                                  • Dose
                                                  • Potassium abnormalities
                                                  • Hyperkalemia
                                                  • Clinical manifestation of hyperkalemia
                                                  • Slide 86
                                                  • Slide 87
                                                  • Hypokalemia
                                                  • Potassium changes associated with alkalosis
                                                  • Slide 90
                                                  • Clinical Manifestation of Abnormalities in potassium
                                                  • Slide 92
                                                  • Calcium
                                                  • هيپوكلسمي یونیزه Calt45 meql
                                                  • علائم هیپوکلسمی
                                                  • Slide 96
                                                  • Slide 97
                                                  • Slide 98
                                                  • Slide 99
                                                  • سایرعلائم
                                                  • درمان
                                                  • هيپركلسمي Cagt55meql
                                                  • علائم
                                                  • علائم قلبی
                                                  • Slide 105
                                                  • Magnesium Abnormalities
                                                  • منیزیوم
                                                  • Hypermagnesemia
                                                  • Clinical manifestation hypermanesemia
                                                  • Slide 110
                                                  • Slide 111
                                                  • Hypomagnesemia
                                                  • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                  • Slide 114
                                                  • Message for Today
                                                  • Slide 116

                                                    Composition of Fluid Compartments

                                                    CATIONS ANIONS

                                                    Na+ 142 Cl - 103

                                                    HC03- 27

                                                    504mdash

                                                    3 PO4

                                                    ---

                                                    K+ 4 organicCa++ 5 Acid 5

                                                    Mg++ 3 Protein 16

                                                    CATIONS ANIONS

                                                    Na+ 144 Cl - 114

                                                    HC03- 30

                                                    504mdash

                                                    K+ 4 3 PO4

                                                    ---

                                                    organic

                                                    Ca++ 3 Acid 5

                                                    Mg++ 2 Protein 1

                                                    CATIONS ANIONS

                                                    K+ 150 HPO4

                                                    150 504

                                                    mdash

                                                    HCO3- 10

                                                    Mg++ 40 Protein 40

                                                    Na+ 10

                                                    154 mEqL 153 mEqL 153 mEqL154 mEqL

                                                    PLASMA INTERSTITAL FLID

                                                    200 mEqL 200 mEqL

                                                    INTRACELLULAR FLID

                                                    Composition of Body FluidsComposition of Body Fluids

                                                    Ca 2+

                                                    Mg 2+

                                                    K+

                                                    Na+

                                                    Cl-

                                                    PO43-

                                                    Organic anion

                                                    HCO3-

                                                    Protein

                                                    0

                                                    50

                                                    50

                                                    100

                                                    150

                                                    100

                                                    150

                                                    Cations Anions

                                                    EC

                                                    FICF

                                                    Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                                                    والکترولیت آب تغییرات روی موثر عوامل

                                                    1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                                                    عمل 2 از قبل والکترولیت آب وضعیت

                                                    اندوکرینوپاتی )3 همراه )بیماریهای

                                                    4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                                                    Reasons for fluid therapyReasons for fluid therapy

                                                    Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                                                    bull Correct hypovolaemiaCorrect hypovolaemia

                                                    bull Maintain cardiac outputMaintain cardiac output

                                                    bull Optimise gas exchangeOptimise gas exchange

                                                    bull Replace electrolytes amp waterReplace electrolytes amp water

                                                    bull Maintain urine outputMaintain urine output

                                                    Colloids + RBCs

                                                    Crystalloids

                                                    Identify what is the goal

                                                    Choose fluid which best achieves the goal

                                                    عروقی داخل مایع حجم ارزیابی

                                                    بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                                                    وریدی محلولهای

                                                    Fluids bull Crystalloids

                                                    bull Colloids

                                                    bull blood

                                                    Which of the following solutions is isotonic

                                                    A D5W

                                                    B 045 saline

                                                    C 09 saline

                                                    D D5 in 09 saline

                                                    SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                                                    ECFECF 142 4 5 103 27 280-310

                                                    Lactated Lactated RingerrsquosRingerrsquos

                                                    130 4 3 109 28 273

                                                    09 NaCl09 NaCl 154 154 308

                                                    045 045 NaClNaCl

                                                    77 77 154

                                                    D5WD5W

                                                    D5045 D5045 NaClNaCl

                                                    77 77 50 406

                                                    3 NaCl3 NaCl 513 513 1026

                                                    6 6 HetastarchHetastarch

                                                    500 154 154 310

                                                    5 5 AlbuminAlbumin

                                                    250500130-160

                                                    lt25130-160

                                                    330

                                                    25 25 AlbuminAlbumin

                                                    2050100130-160

                                                    lt25130-160

                                                    330

                                                    Common parenteral fluid therapyCommon parenteral fluid therapy

                                                    CrystalloidsCrystalloids

                                                    bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                                    Colloid SolutionsColloid Solutions

                                                    bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                                    - Haes-steril 10

                                                    الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                                    کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                                    ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                                    osm=273

                                                    09Nacl

                                                    bull Na=154

                                                    bull CL= 154

                                                    کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                                    PH=56است

                                                    Postoperative (maintenance)

                                                    045Nacl +5 dextrose +KCL

                                                    Perioperative management of fluid balance include

                                                    1 Preoperative evaluation

                                                    2 Intraoperative maintenance

                                                    3 Replacement of fluid losses

                                                    Preexisting fluid deficits

                                                    bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                                    bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                                    Maintenance requirements

                                                    bull Up to 10 kg = 4cckghr

                                                    bull 11-20kg = add 2cckghr

                                                    bull 21kg and above = add 1cckghr

                                                    bull Insensible losses = 2cckghr

                                                    Surgical fluid losses

                                                    Blood loss (measurement)

                                                    1 Suction container

                                                    2 Surgical sponge

                                                    3 Hct and tachycardia not specific

                                                    4 ABG and UO if hypoperfusion occur

                                                    5 Blood loss=31 with crystalloid

                                                    Other losses (third space loss)

                                                    Third space loss

                                                    1 Minimal (herniorrapy) =2-4cckghr

                                                    2 Moderate (cholecystectomy)=4-6cckghr

                                                    3 Severe (bowel resection) = 6-8cckghr

                                                    Crystalloid solution

                                                    1 The main solutions is either glucose or saline

                                                    2 Hypotonic or isotonic or hypertonic

                                                    3 Safe nontoxic reaction free inexpensive

                                                    4 Complication is edema if large volumes are needed

                                                    5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                    Colloids

                                                    1 Albumin

                                                    2 Hydroxyethyl starch

                                                    3 Dextran

                                                    Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                    factor )These colloid is best avoided in patients with

                                                    coagulopaty

                                                    The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                    1000cc

                                                    500cc

                                                    500cc

                                                    500cc

                                                    200

                                                    600

                                                    1000

                                                    Lactated Ringers

                                                    5 Albumin

                                                    6 Hetastarch

                                                    Whole blood

                                                    Blood volumeInfusion volume

                                                    Colloid versus crystalloid solutions

                                                    Transfusion consideration

                                                    bull HB lt7 mg dl increase CO

                                                    bull Ideal Hb is 7-8 mgdl

                                                    bull In IHD patients or pulmonary disease gt 10 mgdl

                                                    بدن مایعات حجم در اختالل

                                                    1 Fluid volume deficit

                                                    2 Fluid volume excess

                                                    Fluid volume deficit(FVD)

                                                    ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                    کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                    ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                    باشد آن با همراه دیگری اختالل مگر

                                                    DEHYDRATION

                                                    سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                    سلولی خارج حجم کاهش علل

                                                    1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                    2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                    کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                    Signs of HypovolemiaSigns of Hypovolemia

                                                    bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                    Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                    bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                    Signs of HypervolemiaSigns of Hypervolemia

                                                    bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                    Especially when hypo-albuminemia

                                                    Management of Management of HypervolemiaHypervolemia

                                                    bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                    Fluid ManagementFluid Management

                                                    bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                    Electrolyte physiology

                                                    Sodium physiology

                                                    Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                    Normal amount 135-145 meql

                                                    Osmotic Pressure

                                                    Calculated serum osmolality =

                                                    2 sodium+ glucose18 + BUN 28

                                                    Osmolality = 290 mosm

                                                    Concentration

                                                    1Serum sodium concentration2Serum osmolarity

                                                    bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                    drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                    DW5)

                                                    Hypernatremia

                                                    Serum Nagt145mEqL

                                                    - Hypernatremia

                                                    Loss of Free Water

                                                    Gain of sodium in excess of water

                                                    Hypernatremia

                                                    -Hypernatremia Hypo volemic

                                                    Hyper volemic

                                                    Normo volemic

                                                    Hypernatremia

                                                    Volume Status

                                                    Normal

                                                    Nonrenal water loss

                                                    Skin

                                                    Gastrointestinal

                                                    Renal water loss

                                                    Renal disease

                                                    Diuretics

                                                    Diabetes insipidus

                                                    High

                                                    Iatrogenic sodium administration

                                                    Mineralocorticoid excess

                                                    Aldosteronism

                                                    Cushingrsquos disease

                                                    Congenital adrenal

                                                    hyperplasia

                                                    Low

                                                    Nonrenal water loss

                                                    Skin

                                                    Gastrointestinal losses

                                                    Renal water losses

                                                    Renal (tubular) Diuretics

                                                    Osmotic diuretics

                                                    Diabetes insipidus

                                                    Adrenal failure

                                                    Asymptomatic

                                                    Hypernatremia Symptomatic (Nagt160 meqL)

                                                    Clinical Manifestations of Abnormalities in Serum Sodium

                                                    Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                    Body system hypernatremia

                                                    Treatment

                                                    Normal saline in hypovolemic patients

                                                    Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                    saline or entral water)

                                                    Water deficit (L)= times TBW

                                                    The formula used to estimate the amount of water required to correct hypernatremia

                                                    Estimate TBW as 55 of lean body mass in men and 45 in women

                                                    Serum sodium-140

                                                    140

                                                    The rate of fluid administration

                                                    1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                    2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                    Hyponatremia Nalt135mEqL

                                                    Causes

                                                    1 Sodium depletion

                                                    2 Sodium dilution

                                                    bull Incidence = 45

                                                    bull After surgery=1

                                                    bull Mortality = 2 times normal

                                                    Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                    volume deficit

                                                    Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                    Sign and symptoms

                                                    bull CNS symptom when Nalt123 meql

                                                    bull Cardiac symptom when Nalt100 meql

                                                    For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                    Body System Hyponatremia

                                                    central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                    reflexes seizures coma increased intracranial pressure

                                                    Musculoskeletal Weakness fatigue muscle crampstwitching

                                                    Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                    Cardiovascular Hypertension and bradycardia if significant increases in

                                                    intracranial pressure

                                                    Tissue Lacrimation salivation

                                                    Renal Oliguria

                                                    Clinical Manifestations of Abnormalities in Serum Sodium

                                                    Treatment

                                                    1=Depend on ECF

                                                    2=CNS sign

                                                    Treatment

                                                    1 Asymptomatic increase the sodium level by no more than

                                                    05-1 meqLh to a maximum increase of 12 meqL per day

                                                    2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                    more than 1meqL per hour until the serum Na level reaches 130

                                                    meqL or neurologic symptoms are improved

                                                    Rapid correction of hyponatremia

                                                    Pontine myelinolysis

                                                    Seizures weaknessparesis akinetic

                                                    movements unresponsiveness

                                                    Permanent brain damage

                                                    Death

                                                    Dose

                                                    Na deficit meq =(140- Na meql) TBW

                                                    باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                    شود اصالح آهسته سپس

                                                    Potassium abnormalities

                                                    bull The average dietary intake of potassium 50-100meqd

                                                    bull The average renal excretion of potassium 10-700 meqd

                                                    - 2 of the total body potassium in ECF (45meqL)

                                                    - Factors that influence serum potassium

                                                    1 Surgical stress

                                                    2 Injury

                                                    3 Acidosis

                                                    4 Tissue catabolism

                                                    Hyperkalemia

                                                    The normal range of serum potassium 35-5 meqL

                                                    Etiology of Hyperkalemia

                                                    Increased intake Potassium supplementation

                                                    Blood transfusions

                                                    Endogenous loaddestruction

                                                    hemolysis rhabdomyolysis

                                                    cruch injury gastrointestinal hemorrhage

                                                    Increased release Acidosis

                                                    Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                    Renal insufficiencyfailure

                                                    Clinical manifestation of hyperkalemia

                                                    System hyperkalemia

                                                    Gastrointestinal Nauseavomiting colic diarrhea

                                                    Neuromuscular weakness paralysis respiratory failure

                                                    Cardiovascular Arrhythmia arrest

                                                    ECG changes Peaked T waves (early change)

                                                    Flattened P wave

                                                    Prolonged PR interval (first-degree block)

                                                    Widened QRS complex

                                                    Sine wave formation

                                                    Ventricular fibrillation

                                                    Treatment

                                                    Treatment of symptomatic hyperkalemia

                                                    Potassium removal Kayexalate

                                                    Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                    Rectal administration is 50 g in 200 mL 20 sorbitol

                                                    Dialysis

                                                    Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                    Bicarbonate 1 vial intravenous

                                                    Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                    HypokalemiaEtiology

                                                    inadequate intake

                                                    Dietary potassium-free intravenous fluids potassium-deficient

                                                    total parenteral nutrition

                                                    Excessive potassium excretion

                                                    Hyperaldosteronism

                                                    Medications

                                                    Gastrointestinal losses

                                                    Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                    Renal loss of potassium (gastric fluid either as vomiting or high

                                                    nasogastric output)

                                                    Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                    Potassium changes associated with alkalosis

                                                    Potassium decrease by 03 meqL for every 01

                                                    increase in PH above normal

                                                    Magnesium Depletion

                                                    (drug induced amphotericin amioglycosides cisplatin)

                                                    Renal potassium wastage

                                                    Hypokalemia

                                                    Magnesium Depletion

                                                    (drug induced amphotericin amioglycosides cisplatin)

                                                    Renal potassium wastage

                                                    Hypokalemia

                                                    Clinical Manifestation of Abnormalities in potassium

                                                    System hypokalemia

                                                    Gastrointestinal Ileus constipation

                                                    Neuromuscular Decreased reflexes fatigue weakness

                                                    paralysis

                                                    Cardiovascular Arrest

                                                    ECG changes U-waves

                                                    T-wave flattening

                                                    ST-segment changes

                                                    Arrhythmias

                                                    Treatment

                                                    Potassium

                                                    Serum potassium level lt40 mEqL

                                                    Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                    times 1 doses

                                                    Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                    Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                    Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                    asymptomatic replace as per above protocol

                                                    Electrolyte Replacement Therapy Protocol

                                                    bull Oral repletion for mild and asymptomatic hypokalemia

                                                    bull IV repletion for severe and symptomatic hypokalemia

                                                    Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                    ( دندانها( ndash استخوانbull كلسيم نقش

                                                    عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                    صاف 2 عضالت انقباض

                                                    هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                    انعقاد 4

                                                    یونیزه Calt45 meql هيپوكلسمي

                                                    عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                    ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                    میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                    ( شود می پیوند شده

                                                    هیپوکلسمی عالئم

                                                    رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                    سایرعالئم

                                                    قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                    درمان

                                                    ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                    Cagt55meql هيپركلسمي

                                                    هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                    عالئم

                                                    bullGI

                                                    bullCardiovascular bullRenal (polyuria)

                                                    bullCNS

                                                    قلبی عالئم

                                                    bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                    QRS شدن )Q-Tوكوتاه

                                                    درمان

                                                    ایزوتونیک 1 نمکی محلول انفوزیون

                                                    الزیکس2

                                                    تونین 3 کلسی

                                                    کورتون4

                                                    دیالیز5

                                                    Magnesium Abnormalities

                                                    Normal dietary intake 20meq (240mg)

                                                    Excretion in both the feces and urine

                                                    Normal serum level 19-25 mgdL

                                                    منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                    تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                    bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                    Hypermagnesemia

                                                    Etiology

                                                    1 Impaired renal function

                                                    2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                    Clinical manifestation hypermanesemia

                                                    System hypermanesemia

                                                    Gastrointestinal Nauseavomiting

                                                    Neuromuscular weakness lethargy Decreased

                                                    reflexes

                                                    Cardiovascular Hypotension arrest

                                                    ECG changes Increased PR interval

                                                    Widened QRS complex

                                                    Elevated T waves

                                                    Treatment

                                                    1 Withhold exogenous sources of magnesium

                                                    2 Correct volume deficit

                                                    3 Correct acidosis if present

                                                    4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                    5 Dialysis (if elevated levels or symptoms persist)

                                                    عالئم

                                                    bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                    meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                    meqL

                                                    Hypomagnesemia

                                                    Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                    homeostasis

                                                    Etiology

                                                    1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                    inadequate supplementation of magnesium)

                                                    2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                    3 GI losses (diarrhea)

                                                    4 Malabsorption

                                                    5 Acute pancreatitis

                                                    6 Diabetic ketoacidosis

                                                    7 Primary aldosteronism

                                                    Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                    1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                    2 Delirium and seizures in severe deficiency

                                                    3 ECG changes Prolonged QT and PR interval

                                                    ST-segment depression

                                                    Flattening or inversion of P waves

                                                    Torsades de pointes

                                                    Arrhythmia

                                                    Treatment

                                                    1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                    2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                    Message for Today

                                                    ICF

                                                    Interstitial

                                                    Pla

                                                    sma

                                                    5 Dex

                                                    bull Do not reccussitate sick patients with any Dextrose solution

                                                    • Fluid and Electrolyte Management of the Surgical Patient
                                                    • Slide 2
                                                    • Slide 3
                                                    • Slide 4
                                                    • Total Body Water
                                                    • Body Fluid Compartments
                                                    • Total body water (TBW)
                                                    • Body compartment fluid
                                                    • Example men with 70kg
                                                    • Fluid compartments
                                                    • Slide 11
                                                    • Slide 12
                                                    • Slide 13
                                                    • Slide 14
                                                    • Slide 15
                                                    • Colloid osmotic pressure
                                                    • Slide 17
                                                    • Slide 18
                                                    • Slide 19
                                                    • Cell Membrane
                                                    • Slide 21
                                                    • Slide 22
                                                    • Slide 23
                                                    • Slide 24
                                                    • Slide 25
                                                    • Composition of Fluid Compartments
                                                    • Composition of Body Fluids
                                                    • عوامل موثر روی تغییرات آب والکترولیت
                                                    • Reasons for fluid therapy
                                                    • ارزیابی حجم مایع داخل عروقی
                                                    • محلولهای وریدی
                                                    • Fluids
                                                    • Slide 33
                                                    • Slide 34
                                                    • Slide 35
                                                    • Crystalloids
                                                    • Colloid Solutions
                                                    • رینگر لاکتات
                                                    • 09Nacl
                                                    • Postoperative (maintenance)
                                                    • Slide 41
                                                    • Preexisting fluid deficits
                                                    • Maintenance requirements
                                                    • Surgical fluid losses
                                                    • Third space loss
                                                    • Crystalloid solution
                                                    • Colloids
                                                    • Complications
                                                    • The Influence of Colloid amp Crystalloid on Blood Volume
                                                    • Colloid versus crystalloid solutions
                                                    • Transfusion consideration
                                                    • اختلال در حجم مایعات بدن
                                                    • Fluid volume deficit (FVD)
                                                    • DEHYDRATION
                                                    • علل کاهش حجم خارج سلولی
                                                    • Signs of Hypovolemia
                                                    • Clinical Diagnosis of Hypovolemia
                                                    • Signs of Hypervolemia
                                                    • Management of Hypervolemia
                                                    • Fluid Management
                                                    • Electrolyte physiology
                                                    • Sodium physiology
                                                    • Osmotic Pressure
                                                    • Concentration
                                                    • Hypernatremia
                                                    • - Hypernatremia
                                                    • Slide 67
                                                    • Slide 68
                                                    • Clinical Manifestations of Abnormalities in Serum Sodium
                                                    • Treatment
                                                    • Water deficit (L)= times TBW
                                                    • The rate of fluid administration
                                                    • Hyponatremia Nalt135mEqL
                                                    • Slide 74
                                                    • Sodium depletion
                                                    • Sodium dilution
                                                    • Sign and symptoms
                                                    • Slide 78
                                                    • Treatment
                                                    • Slide 80
                                                    • Slide 81
                                                    • Dose
                                                    • Potassium abnormalities
                                                    • Hyperkalemia
                                                    • Clinical manifestation of hyperkalemia
                                                    • Slide 86
                                                    • Slide 87
                                                    • Hypokalemia
                                                    • Potassium changes associated with alkalosis
                                                    • Slide 90
                                                    • Clinical Manifestation of Abnormalities in potassium
                                                    • Slide 92
                                                    • Calcium
                                                    • هيپوكلسمي یونیزه Calt45 meql
                                                    • علائم هیپوکلسمی
                                                    • Slide 96
                                                    • Slide 97
                                                    • Slide 98
                                                    • Slide 99
                                                    • سایرعلائم
                                                    • درمان
                                                    • هيپركلسمي Cagt55meql
                                                    • علائم
                                                    • علائم قلبی
                                                    • Slide 105
                                                    • Magnesium Abnormalities
                                                    • منیزیوم
                                                    • Hypermagnesemia
                                                    • Clinical manifestation hypermanesemia
                                                    • Slide 110
                                                    • Slide 111
                                                    • Hypomagnesemia
                                                    • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                    • Slide 114
                                                    • Message for Today
                                                    • Slide 116

                                                      Composition of Body FluidsComposition of Body Fluids

                                                      Ca 2+

                                                      Mg 2+

                                                      K+

                                                      Na+

                                                      Cl-

                                                      PO43-

                                                      Organic anion

                                                      HCO3-

                                                      Protein

                                                      0

                                                      50

                                                      50

                                                      100

                                                      150

                                                      100

                                                      150

                                                      Cations Anions

                                                      EC

                                                      FICF

                                                      Osmolarity = solute(solute+solvent)Osmolarity = solute(solute+solvent) Osmolality = solutesolvent (290~310mOsmL)Osmolality = solutesolvent (290~310mOsmL) Tonicity = effective osmolalityTonicity = effective osmolality Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28)Plasma osmolility = 2 x (Na) + (Glucose18) + (Urea28) Plasma tonicity = 2 x (Na) + (Glucose18)Plasma tonicity = 2 x (Na) + (Glucose18)

                                                      والکترولیت آب تغییرات روی موثر عوامل

                                                      1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                                                      عمل 2 از قبل والکترولیت آب وضعیت

                                                      اندوکرینوپاتی )3 همراه )بیماریهای

                                                      4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                                                      Reasons for fluid therapyReasons for fluid therapy

                                                      Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                                                      bull Correct hypovolaemiaCorrect hypovolaemia

                                                      bull Maintain cardiac outputMaintain cardiac output

                                                      bull Optimise gas exchangeOptimise gas exchange

                                                      bull Replace electrolytes amp waterReplace electrolytes amp water

                                                      bull Maintain urine outputMaintain urine output

                                                      Colloids + RBCs

                                                      Crystalloids

                                                      Identify what is the goal

                                                      Choose fluid which best achieves the goal

                                                      عروقی داخل مایع حجم ارزیابی

                                                      بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                                                      وریدی محلولهای

                                                      Fluids bull Crystalloids

                                                      bull Colloids

                                                      bull blood

                                                      Which of the following solutions is isotonic

                                                      A D5W

                                                      B 045 saline

                                                      C 09 saline

                                                      D D5 in 09 saline

                                                      SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                                                      ECFECF 142 4 5 103 27 280-310

                                                      Lactated Lactated RingerrsquosRingerrsquos

                                                      130 4 3 109 28 273

                                                      09 NaCl09 NaCl 154 154 308

                                                      045 045 NaClNaCl

                                                      77 77 154

                                                      D5WD5W

                                                      D5045 D5045 NaClNaCl

                                                      77 77 50 406

                                                      3 NaCl3 NaCl 513 513 1026

                                                      6 6 HetastarchHetastarch

                                                      500 154 154 310

                                                      5 5 AlbuminAlbumin

                                                      250500130-160

                                                      lt25130-160

                                                      330

                                                      25 25 AlbuminAlbumin

                                                      2050100130-160

                                                      lt25130-160

                                                      330

                                                      Common parenteral fluid therapyCommon parenteral fluid therapy

                                                      CrystalloidsCrystalloids

                                                      bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                                      Colloid SolutionsColloid Solutions

                                                      bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                                      - Haes-steril 10

                                                      الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                                      کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                                      ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                                      osm=273

                                                      09Nacl

                                                      bull Na=154

                                                      bull CL= 154

                                                      کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                                      PH=56است

                                                      Postoperative (maintenance)

                                                      045Nacl +5 dextrose +KCL

                                                      Perioperative management of fluid balance include

                                                      1 Preoperative evaluation

                                                      2 Intraoperative maintenance

                                                      3 Replacement of fluid losses

                                                      Preexisting fluid deficits

                                                      bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                                      bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                                      Maintenance requirements

                                                      bull Up to 10 kg = 4cckghr

                                                      bull 11-20kg = add 2cckghr

                                                      bull 21kg and above = add 1cckghr

                                                      bull Insensible losses = 2cckghr

                                                      Surgical fluid losses

                                                      Blood loss (measurement)

                                                      1 Suction container

                                                      2 Surgical sponge

                                                      3 Hct and tachycardia not specific

                                                      4 ABG and UO if hypoperfusion occur

                                                      5 Blood loss=31 with crystalloid

                                                      Other losses (third space loss)

                                                      Third space loss

                                                      1 Minimal (herniorrapy) =2-4cckghr

                                                      2 Moderate (cholecystectomy)=4-6cckghr

                                                      3 Severe (bowel resection) = 6-8cckghr

                                                      Crystalloid solution

                                                      1 The main solutions is either glucose or saline

                                                      2 Hypotonic or isotonic or hypertonic

                                                      3 Safe nontoxic reaction free inexpensive

                                                      4 Complication is edema if large volumes are needed

                                                      5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                      Colloids

                                                      1 Albumin

                                                      2 Hydroxyethyl starch

                                                      3 Dextran

                                                      Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                      factor )These colloid is best avoided in patients with

                                                      coagulopaty

                                                      The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                      1000cc

                                                      500cc

                                                      500cc

                                                      500cc

                                                      200

                                                      600

                                                      1000

                                                      Lactated Ringers

                                                      5 Albumin

                                                      6 Hetastarch

                                                      Whole blood

                                                      Blood volumeInfusion volume

                                                      Colloid versus crystalloid solutions

                                                      Transfusion consideration

                                                      bull HB lt7 mg dl increase CO

                                                      bull Ideal Hb is 7-8 mgdl

                                                      bull In IHD patients or pulmonary disease gt 10 mgdl

                                                      بدن مایعات حجم در اختالل

                                                      1 Fluid volume deficit

                                                      2 Fluid volume excess

                                                      Fluid volume deficit(FVD)

                                                      ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                      کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                      ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                      باشد آن با همراه دیگری اختالل مگر

                                                      DEHYDRATION

                                                      سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                      سلولی خارج حجم کاهش علل

                                                      1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                      2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                      کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                      Signs of HypovolemiaSigns of Hypovolemia

                                                      bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                      Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                      bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                      Signs of HypervolemiaSigns of Hypervolemia

                                                      bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                      Especially when hypo-albuminemia

                                                      Management of Management of HypervolemiaHypervolemia

                                                      bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                      Fluid ManagementFluid Management

                                                      bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                      Electrolyte physiology

                                                      Sodium physiology

                                                      Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                      Normal amount 135-145 meql

                                                      Osmotic Pressure

                                                      Calculated serum osmolality =

                                                      2 sodium+ glucose18 + BUN 28

                                                      Osmolality = 290 mosm

                                                      Concentration

                                                      1Serum sodium concentration2Serum osmolarity

                                                      bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                      drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                      DW5)

                                                      Hypernatremia

                                                      Serum Nagt145mEqL

                                                      - Hypernatremia

                                                      Loss of Free Water

                                                      Gain of sodium in excess of water

                                                      Hypernatremia

                                                      -Hypernatremia Hypo volemic

                                                      Hyper volemic

                                                      Normo volemic

                                                      Hypernatremia

                                                      Volume Status

                                                      Normal

                                                      Nonrenal water loss

                                                      Skin

                                                      Gastrointestinal

                                                      Renal water loss

                                                      Renal disease

                                                      Diuretics

                                                      Diabetes insipidus

                                                      High

                                                      Iatrogenic sodium administration

                                                      Mineralocorticoid excess

                                                      Aldosteronism

                                                      Cushingrsquos disease

                                                      Congenital adrenal

                                                      hyperplasia

                                                      Low

                                                      Nonrenal water loss

                                                      Skin

                                                      Gastrointestinal losses

                                                      Renal water losses

                                                      Renal (tubular) Diuretics

                                                      Osmotic diuretics

                                                      Diabetes insipidus

                                                      Adrenal failure

                                                      Asymptomatic

                                                      Hypernatremia Symptomatic (Nagt160 meqL)

                                                      Clinical Manifestations of Abnormalities in Serum Sodium

                                                      Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                      Body system hypernatremia

                                                      Treatment

                                                      Normal saline in hypovolemic patients

                                                      Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                      saline or entral water)

                                                      Water deficit (L)= times TBW

                                                      The formula used to estimate the amount of water required to correct hypernatremia

                                                      Estimate TBW as 55 of lean body mass in men and 45 in women

                                                      Serum sodium-140

                                                      140

                                                      The rate of fluid administration

                                                      1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                      2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                      Hyponatremia Nalt135mEqL

                                                      Causes

                                                      1 Sodium depletion

                                                      2 Sodium dilution

                                                      bull Incidence = 45

                                                      bull After surgery=1

                                                      bull Mortality = 2 times normal

                                                      Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                      volume deficit

                                                      Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                      Sign and symptoms

                                                      bull CNS symptom when Nalt123 meql

                                                      bull Cardiac symptom when Nalt100 meql

                                                      For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                      Body System Hyponatremia

                                                      central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                      reflexes seizures coma increased intracranial pressure

                                                      Musculoskeletal Weakness fatigue muscle crampstwitching

                                                      Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                      Cardiovascular Hypertension and bradycardia if significant increases in

                                                      intracranial pressure

                                                      Tissue Lacrimation salivation

                                                      Renal Oliguria

                                                      Clinical Manifestations of Abnormalities in Serum Sodium

                                                      Treatment

                                                      1=Depend on ECF

                                                      2=CNS sign

                                                      Treatment

                                                      1 Asymptomatic increase the sodium level by no more than

                                                      05-1 meqLh to a maximum increase of 12 meqL per day

                                                      2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                      more than 1meqL per hour until the serum Na level reaches 130

                                                      meqL or neurologic symptoms are improved

                                                      Rapid correction of hyponatremia

                                                      Pontine myelinolysis

                                                      Seizures weaknessparesis akinetic

                                                      movements unresponsiveness

                                                      Permanent brain damage

                                                      Death

                                                      Dose

                                                      Na deficit meq =(140- Na meql) TBW

                                                      باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                      شود اصالح آهسته سپس

                                                      Potassium abnormalities

                                                      bull The average dietary intake of potassium 50-100meqd

                                                      bull The average renal excretion of potassium 10-700 meqd

                                                      - 2 of the total body potassium in ECF (45meqL)

                                                      - Factors that influence serum potassium

                                                      1 Surgical stress

                                                      2 Injury

                                                      3 Acidosis

                                                      4 Tissue catabolism

                                                      Hyperkalemia

                                                      The normal range of serum potassium 35-5 meqL

                                                      Etiology of Hyperkalemia

                                                      Increased intake Potassium supplementation

                                                      Blood transfusions

                                                      Endogenous loaddestruction

                                                      hemolysis rhabdomyolysis

                                                      cruch injury gastrointestinal hemorrhage

                                                      Increased release Acidosis

                                                      Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                      Renal insufficiencyfailure

                                                      Clinical manifestation of hyperkalemia

                                                      System hyperkalemia

                                                      Gastrointestinal Nauseavomiting colic diarrhea

                                                      Neuromuscular weakness paralysis respiratory failure

                                                      Cardiovascular Arrhythmia arrest

                                                      ECG changes Peaked T waves (early change)

                                                      Flattened P wave

                                                      Prolonged PR interval (first-degree block)

                                                      Widened QRS complex

                                                      Sine wave formation

                                                      Ventricular fibrillation

                                                      Treatment

                                                      Treatment of symptomatic hyperkalemia

                                                      Potassium removal Kayexalate

                                                      Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                      Rectal administration is 50 g in 200 mL 20 sorbitol

                                                      Dialysis

                                                      Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                      Bicarbonate 1 vial intravenous

                                                      Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                      HypokalemiaEtiology

                                                      inadequate intake

                                                      Dietary potassium-free intravenous fluids potassium-deficient

                                                      total parenteral nutrition

                                                      Excessive potassium excretion

                                                      Hyperaldosteronism

                                                      Medications

                                                      Gastrointestinal losses

                                                      Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                      Renal loss of potassium (gastric fluid either as vomiting or high

                                                      nasogastric output)

                                                      Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                      Potassium changes associated with alkalosis

                                                      Potassium decrease by 03 meqL for every 01

                                                      increase in PH above normal

                                                      Magnesium Depletion

                                                      (drug induced amphotericin amioglycosides cisplatin)

                                                      Renal potassium wastage

                                                      Hypokalemia

                                                      Magnesium Depletion

                                                      (drug induced amphotericin amioglycosides cisplatin)

                                                      Renal potassium wastage

                                                      Hypokalemia

                                                      Clinical Manifestation of Abnormalities in potassium

                                                      System hypokalemia

                                                      Gastrointestinal Ileus constipation

                                                      Neuromuscular Decreased reflexes fatigue weakness

                                                      paralysis

                                                      Cardiovascular Arrest

                                                      ECG changes U-waves

                                                      T-wave flattening

                                                      ST-segment changes

                                                      Arrhythmias

                                                      Treatment

                                                      Potassium

                                                      Serum potassium level lt40 mEqL

                                                      Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                      times 1 doses

                                                      Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                      Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                      Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                      asymptomatic replace as per above protocol

                                                      Electrolyte Replacement Therapy Protocol

                                                      bull Oral repletion for mild and asymptomatic hypokalemia

                                                      bull IV repletion for severe and symptomatic hypokalemia

                                                      Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                      ( دندانها( ndash استخوانbull كلسيم نقش

                                                      عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                      صاف 2 عضالت انقباض

                                                      هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                      انعقاد 4

                                                      یونیزه Calt45 meql هيپوكلسمي

                                                      عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                      ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                      میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                      ( شود می پیوند شده

                                                      هیپوکلسمی عالئم

                                                      رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                      سایرعالئم

                                                      قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                      درمان

                                                      ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                      Cagt55meql هيپركلسمي

                                                      هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                      عالئم

                                                      bullGI

                                                      bullCardiovascular bullRenal (polyuria)

                                                      bullCNS

                                                      قلبی عالئم

                                                      bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                      QRS شدن )Q-Tوكوتاه

                                                      درمان

                                                      ایزوتونیک 1 نمکی محلول انفوزیون

                                                      الزیکس2

                                                      تونین 3 کلسی

                                                      کورتون4

                                                      دیالیز5

                                                      Magnesium Abnormalities

                                                      Normal dietary intake 20meq (240mg)

                                                      Excretion in both the feces and urine

                                                      Normal serum level 19-25 mgdL

                                                      منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                      تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                      bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                      Hypermagnesemia

                                                      Etiology

                                                      1 Impaired renal function

                                                      2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                      Clinical manifestation hypermanesemia

                                                      System hypermanesemia

                                                      Gastrointestinal Nauseavomiting

                                                      Neuromuscular weakness lethargy Decreased

                                                      reflexes

                                                      Cardiovascular Hypotension arrest

                                                      ECG changes Increased PR interval

                                                      Widened QRS complex

                                                      Elevated T waves

                                                      Treatment

                                                      1 Withhold exogenous sources of magnesium

                                                      2 Correct volume deficit

                                                      3 Correct acidosis if present

                                                      4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                      5 Dialysis (if elevated levels or symptoms persist)

                                                      عالئم

                                                      bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                      meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                      meqL

                                                      Hypomagnesemia

                                                      Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                      homeostasis

                                                      Etiology

                                                      1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                      inadequate supplementation of magnesium)

                                                      2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                      3 GI losses (diarrhea)

                                                      4 Malabsorption

                                                      5 Acute pancreatitis

                                                      6 Diabetic ketoacidosis

                                                      7 Primary aldosteronism

                                                      Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                      1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                      2 Delirium and seizures in severe deficiency

                                                      3 ECG changes Prolonged QT and PR interval

                                                      ST-segment depression

                                                      Flattening or inversion of P waves

                                                      Torsades de pointes

                                                      Arrhythmia

                                                      Treatment

                                                      1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                      2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                      Message for Today

                                                      ICF

                                                      Interstitial

                                                      Pla

                                                      sma

                                                      5 Dex

                                                      bull Do not reccussitate sick patients with any Dextrose solution

                                                      • Fluid and Electrolyte Management of the Surgical Patient
                                                      • Slide 2
                                                      • Slide 3
                                                      • Slide 4
                                                      • Total Body Water
                                                      • Body Fluid Compartments
                                                      • Total body water (TBW)
                                                      • Body compartment fluid
                                                      • Example men with 70kg
                                                      • Fluid compartments
                                                      • Slide 11
                                                      • Slide 12
                                                      • Slide 13
                                                      • Slide 14
                                                      • Slide 15
                                                      • Colloid osmotic pressure
                                                      • Slide 17
                                                      • Slide 18
                                                      • Slide 19
                                                      • Cell Membrane
                                                      • Slide 21
                                                      • Slide 22
                                                      • Slide 23
                                                      • Slide 24
                                                      • Slide 25
                                                      • Composition of Fluid Compartments
                                                      • Composition of Body Fluids
                                                      • عوامل موثر روی تغییرات آب والکترولیت
                                                      • Reasons for fluid therapy
                                                      • ارزیابی حجم مایع داخل عروقی
                                                      • محلولهای وریدی
                                                      • Fluids
                                                      • Slide 33
                                                      • Slide 34
                                                      • Slide 35
                                                      • Crystalloids
                                                      • Colloid Solutions
                                                      • رینگر لاکتات
                                                      • 09Nacl
                                                      • Postoperative (maintenance)
                                                      • Slide 41
                                                      • Preexisting fluid deficits
                                                      • Maintenance requirements
                                                      • Surgical fluid losses
                                                      • Third space loss
                                                      • Crystalloid solution
                                                      • Colloids
                                                      • Complications
                                                      • The Influence of Colloid amp Crystalloid on Blood Volume
                                                      • Colloid versus crystalloid solutions
                                                      • Transfusion consideration
                                                      • اختلال در حجم مایعات بدن
                                                      • Fluid volume deficit (FVD)
                                                      • DEHYDRATION
                                                      • علل کاهش حجم خارج سلولی
                                                      • Signs of Hypovolemia
                                                      • Clinical Diagnosis of Hypovolemia
                                                      • Signs of Hypervolemia
                                                      • Management of Hypervolemia
                                                      • Fluid Management
                                                      • Electrolyte physiology
                                                      • Sodium physiology
                                                      • Osmotic Pressure
                                                      • Concentration
                                                      • Hypernatremia
                                                      • - Hypernatremia
                                                      • Slide 67
                                                      • Slide 68
                                                      • Clinical Manifestations of Abnormalities in Serum Sodium
                                                      • Treatment
                                                      • Water deficit (L)= times TBW
                                                      • The rate of fluid administration
                                                      • Hyponatremia Nalt135mEqL
                                                      • Slide 74
                                                      • Sodium depletion
                                                      • Sodium dilution
                                                      • Sign and symptoms
                                                      • Slide 78
                                                      • Treatment
                                                      • Slide 80
                                                      • Slide 81
                                                      • Dose
                                                      • Potassium abnormalities
                                                      • Hyperkalemia
                                                      • Clinical manifestation of hyperkalemia
                                                      • Slide 86
                                                      • Slide 87
                                                      • Hypokalemia
                                                      • Potassium changes associated with alkalosis
                                                      • Slide 90
                                                      • Clinical Manifestation of Abnormalities in potassium
                                                      • Slide 92
                                                      • Calcium
                                                      • هيپوكلسمي یونیزه Calt45 meql
                                                      • علائم هیپوکلسمی
                                                      • Slide 96
                                                      • Slide 97
                                                      • Slide 98
                                                      • Slide 99
                                                      • سایرعلائم
                                                      • درمان
                                                      • هيپركلسمي Cagt55meql
                                                      • علائم
                                                      • علائم قلبی
                                                      • Slide 105
                                                      • Magnesium Abnormalities
                                                      • منیزیوم
                                                      • Hypermagnesemia
                                                      • Clinical manifestation hypermanesemia
                                                      • Slide 110
                                                      • Slide 111
                                                      • Hypomagnesemia
                                                      • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                      • Slide 114
                                                      • Message for Today
                                                      • Slide 116

                                                        والکترولیت آب تغییرات روی موثر عوامل

                                                        1 ndash - آب ) تبخیر خونریزی میزان جراحی عمل نوعسوم ( فضای حجم

                                                        عمل 2 از قبل والکترولیت آب وضعیت

                                                        اندوکرینوپاتی )3 همراه )بیماریهای

                                                        4 - - پروپوفل ) نسدونال بیهوشی داروهای -MRاثرRA)

                                                        Reasons for fluid therapyReasons for fluid therapy

                                                        Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                                                        bull Correct hypovolaemiaCorrect hypovolaemia

                                                        bull Maintain cardiac outputMaintain cardiac output

                                                        bull Optimise gas exchangeOptimise gas exchange

                                                        bull Replace electrolytes amp waterReplace electrolytes amp water

                                                        bull Maintain urine outputMaintain urine output

                                                        Colloids + RBCs

                                                        Crystalloids

                                                        Identify what is the goal

                                                        Choose fluid which best achieves the goal

                                                        عروقی داخل مایع حجم ارزیابی

                                                        بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                                                        وریدی محلولهای

                                                        Fluids bull Crystalloids

                                                        bull Colloids

                                                        bull blood

                                                        Which of the following solutions is isotonic

                                                        A D5W

                                                        B 045 saline

                                                        C 09 saline

                                                        D D5 in 09 saline

                                                        SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                                                        ECFECF 142 4 5 103 27 280-310

                                                        Lactated Lactated RingerrsquosRingerrsquos

                                                        130 4 3 109 28 273

                                                        09 NaCl09 NaCl 154 154 308

                                                        045 045 NaClNaCl

                                                        77 77 154

                                                        D5WD5W

                                                        D5045 D5045 NaClNaCl

                                                        77 77 50 406

                                                        3 NaCl3 NaCl 513 513 1026

                                                        6 6 HetastarchHetastarch

                                                        500 154 154 310

                                                        5 5 AlbuminAlbumin

                                                        250500130-160

                                                        lt25130-160

                                                        330

                                                        25 25 AlbuminAlbumin

                                                        2050100130-160

                                                        lt25130-160

                                                        330

                                                        Common parenteral fluid therapyCommon parenteral fluid therapy

                                                        CrystalloidsCrystalloids

                                                        bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                                        Colloid SolutionsColloid Solutions

                                                        bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                                        - Haes-steril 10

                                                        الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                                        کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                                        ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                                        osm=273

                                                        09Nacl

                                                        bull Na=154

                                                        bull CL= 154

                                                        کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                                        PH=56است

                                                        Postoperative (maintenance)

                                                        045Nacl +5 dextrose +KCL

                                                        Perioperative management of fluid balance include

                                                        1 Preoperative evaluation

                                                        2 Intraoperative maintenance

                                                        3 Replacement of fluid losses

                                                        Preexisting fluid deficits

                                                        bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                                        bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                                        Maintenance requirements

                                                        bull Up to 10 kg = 4cckghr

                                                        bull 11-20kg = add 2cckghr

                                                        bull 21kg and above = add 1cckghr

                                                        bull Insensible losses = 2cckghr

                                                        Surgical fluid losses

                                                        Blood loss (measurement)

                                                        1 Suction container

                                                        2 Surgical sponge

                                                        3 Hct and tachycardia not specific

                                                        4 ABG and UO if hypoperfusion occur

                                                        5 Blood loss=31 with crystalloid

                                                        Other losses (third space loss)

                                                        Third space loss

                                                        1 Minimal (herniorrapy) =2-4cckghr

                                                        2 Moderate (cholecystectomy)=4-6cckghr

                                                        3 Severe (bowel resection) = 6-8cckghr

                                                        Crystalloid solution

                                                        1 The main solutions is either glucose or saline

                                                        2 Hypotonic or isotonic or hypertonic

                                                        3 Safe nontoxic reaction free inexpensive

                                                        4 Complication is edema if large volumes are needed

                                                        5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                        Colloids

                                                        1 Albumin

                                                        2 Hydroxyethyl starch

                                                        3 Dextran

                                                        Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                        factor )These colloid is best avoided in patients with

                                                        coagulopaty

                                                        The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                        1000cc

                                                        500cc

                                                        500cc

                                                        500cc

                                                        200

                                                        600

                                                        1000

                                                        Lactated Ringers

                                                        5 Albumin

                                                        6 Hetastarch

                                                        Whole blood

                                                        Blood volumeInfusion volume

                                                        Colloid versus crystalloid solutions

                                                        Transfusion consideration

                                                        bull HB lt7 mg dl increase CO

                                                        bull Ideal Hb is 7-8 mgdl

                                                        bull In IHD patients or pulmonary disease gt 10 mgdl

                                                        بدن مایعات حجم در اختالل

                                                        1 Fluid volume deficit

                                                        2 Fluid volume excess

                                                        Fluid volume deficit(FVD)

                                                        ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                        کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                        ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                        باشد آن با همراه دیگری اختالل مگر

                                                        DEHYDRATION

                                                        سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                        سلولی خارج حجم کاهش علل

                                                        1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                        2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                        کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                        Signs of HypovolemiaSigns of Hypovolemia

                                                        bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                        Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                        bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                        Signs of HypervolemiaSigns of Hypervolemia

                                                        bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                        Especially when hypo-albuminemia

                                                        Management of Management of HypervolemiaHypervolemia

                                                        bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                        Fluid ManagementFluid Management

                                                        bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                        Electrolyte physiology

                                                        Sodium physiology

                                                        Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                        Normal amount 135-145 meql

                                                        Osmotic Pressure

                                                        Calculated serum osmolality =

                                                        2 sodium+ glucose18 + BUN 28

                                                        Osmolality = 290 mosm

                                                        Concentration

                                                        1Serum sodium concentration2Serum osmolarity

                                                        bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                        drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                        DW5)

                                                        Hypernatremia

                                                        Serum Nagt145mEqL

                                                        - Hypernatremia

                                                        Loss of Free Water

                                                        Gain of sodium in excess of water

                                                        Hypernatremia

                                                        -Hypernatremia Hypo volemic

                                                        Hyper volemic

                                                        Normo volemic

                                                        Hypernatremia

                                                        Volume Status

                                                        Normal

                                                        Nonrenal water loss

                                                        Skin

                                                        Gastrointestinal

                                                        Renal water loss

                                                        Renal disease

                                                        Diuretics

                                                        Diabetes insipidus

                                                        High

                                                        Iatrogenic sodium administration

                                                        Mineralocorticoid excess

                                                        Aldosteronism

                                                        Cushingrsquos disease

                                                        Congenital adrenal

                                                        hyperplasia

                                                        Low

                                                        Nonrenal water loss

                                                        Skin

                                                        Gastrointestinal losses

                                                        Renal water losses

                                                        Renal (tubular) Diuretics

                                                        Osmotic diuretics

                                                        Diabetes insipidus

                                                        Adrenal failure

                                                        Asymptomatic

                                                        Hypernatremia Symptomatic (Nagt160 meqL)

                                                        Clinical Manifestations of Abnormalities in Serum Sodium

                                                        Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                        Body system hypernatremia

                                                        Treatment

                                                        Normal saline in hypovolemic patients

                                                        Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                        saline or entral water)

                                                        Water deficit (L)= times TBW

                                                        The formula used to estimate the amount of water required to correct hypernatremia

                                                        Estimate TBW as 55 of lean body mass in men and 45 in women

                                                        Serum sodium-140

                                                        140

                                                        The rate of fluid administration

                                                        1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                        2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                        Hyponatremia Nalt135mEqL

                                                        Causes

                                                        1 Sodium depletion

                                                        2 Sodium dilution

                                                        bull Incidence = 45

                                                        bull After surgery=1

                                                        bull Mortality = 2 times normal

                                                        Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                        volume deficit

                                                        Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                        Sign and symptoms

                                                        bull CNS symptom when Nalt123 meql

                                                        bull Cardiac symptom when Nalt100 meql

                                                        For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                        Body System Hyponatremia

                                                        central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                        reflexes seizures coma increased intracranial pressure

                                                        Musculoskeletal Weakness fatigue muscle crampstwitching

                                                        Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                        Cardiovascular Hypertension and bradycardia if significant increases in

                                                        intracranial pressure

                                                        Tissue Lacrimation salivation

                                                        Renal Oliguria

                                                        Clinical Manifestations of Abnormalities in Serum Sodium

                                                        Treatment

                                                        1=Depend on ECF

                                                        2=CNS sign

                                                        Treatment

                                                        1 Asymptomatic increase the sodium level by no more than

                                                        05-1 meqLh to a maximum increase of 12 meqL per day

                                                        2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                        more than 1meqL per hour until the serum Na level reaches 130

                                                        meqL or neurologic symptoms are improved

                                                        Rapid correction of hyponatremia

                                                        Pontine myelinolysis

                                                        Seizures weaknessparesis akinetic

                                                        movements unresponsiveness

                                                        Permanent brain damage

                                                        Death

                                                        Dose

                                                        Na deficit meq =(140- Na meql) TBW

                                                        باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                        شود اصالح آهسته سپس

                                                        Potassium abnormalities

                                                        bull The average dietary intake of potassium 50-100meqd

                                                        bull The average renal excretion of potassium 10-700 meqd

                                                        - 2 of the total body potassium in ECF (45meqL)

                                                        - Factors that influence serum potassium

                                                        1 Surgical stress

                                                        2 Injury

                                                        3 Acidosis

                                                        4 Tissue catabolism

                                                        Hyperkalemia

                                                        The normal range of serum potassium 35-5 meqL

                                                        Etiology of Hyperkalemia

                                                        Increased intake Potassium supplementation

                                                        Blood transfusions

                                                        Endogenous loaddestruction

                                                        hemolysis rhabdomyolysis

                                                        cruch injury gastrointestinal hemorrhage

                                                        Increased release Acidosis

                                                        Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                        Renal insufficiencyfailure

                                                        Clinical manifestation of hyperkalemia

                                                        System hyperkalemia

                                                        Gastrointestinal Nauseavomiting colic diarrhea

                                                        Neuromuscular weakness paralysis respiratory failure

                                                        Cardiovascular Arrhythmia arrest

                                                        ECG changes Peaked T waves (early change)

                                                        Flattened P wave

                                                        Prolonged PR interval (first-degree block)

                                                        Widened QRS complex

                                                        Sine wave formation

                                                        Ventricular fibrillation

                                                        Treatment

                                                        Treatment of symptomatic hyperkalemia

                                                        Potassium removal Kayexalate

                                                        Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                        Rectal administration is 50 g in 200 mL 20 sorbitol

                                                        Dialysis

                                                        Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                        Bicarbonate 1 vial intravenous

                                                        Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                        HypokalemiaEtiology

                                                        inadequate intake

                                                        Dietary potassium-free intravenous fluids potassium-deficient

                                                        total parenteral nutrition

                                                        Excessive potassium excretion

                                                        Hyperaldosteronism

                                                        Medications

                                                        Gastrointestinal losses

                                                        Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                        Renal loss of potassium (gastric fluid either as vomiting or high

                                                        nasogastric output)

                                                        Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                        Potassium changes associated with alkalosis

                                                        Potassium decrease by 03 meqL for every 01

                                                        increase in PH above normal

                                                        Magnesium Depletion

                                                        (drug induced amphotericin amioglycosides cisplatin)

                                                        Renal potassium wastage

                                                        Hypokalemia

                                                        Magnesium Depletion

                                                        (drug induced amphotericin amioglycosides cisplatin)

                                                        Renal potassium wastage

                                                        Hypokalemia

                                                        Clinical Manifestation of Abnormalities in potassium

                                                        System hypokalemia

                                                        Gastrointestinal Ileus constipation

                                                        Neuromuscular Decreased reflexes fatigue weakness

                                                        paralysis

                                                        Cardiovascular Arrest

                                                        ECG changes U-waves

                                                        T-wave flattening

                                                        ST-segment changes

                                                        Arrhythmias

                                                        Treatment

                                                        Potassium

                                                        Serum potassium level lt40 mEqL

                                                        Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                        times 1 doses

                                                        Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                        Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                        Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                        asymptomatic replace as per above protocol

                                                        Electrolyte Replacement Therapy Protocol

                                                        bull Oral repletion for mild and asymptomatic hypokalemia

                                                        bull IV repletion for severe and symptomatic hypokalemia

                                                        Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                        ( دندانها( ndash استخوانbull كلسيم نقش

                                                        عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                        صاف 2 عضالت انقباض

                                                        هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                        انعقاد 4

                                                        یونیزه Calt45 meql هيپوكلسمي

                                                        عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                        ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                        میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                        ( شود می پیوند شده

                                                        هیپوکلسمی عالئم

                                                        رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                        سایرعالئم

                                                        قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                        درمان

                                                        ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                        Cagt55meql هيپركلسمي

                                                        هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                        عالئم

                                                        bullGI

                                                        bullCardiovascular bullRenal (polyuria)

                                                        bullCNS

                                                        قلبی عالئم

                                                        bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                        QRS شدن )Q-Tوكوتاه

                                                        درمان

                                                        ایزوتونیک 1 نمکی محلول انفوزیون

                                                        الزیکس2

                                                        تونین 3 کلسی

                                                        کورتون4

                                                        دیالیز5

                                                        Magnesium Abnormalities

                                                        Normal dietary intake 20meq (240mg)

                                                        Excretion in both the feces and urine

                                                        Normal serum level 19-25 mgdL

                                                        منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                        تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                        bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                        Hypermagnesemia

                                                        Etiology

                                                        1 Impaired renal function

                                                        2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                        Clinical manifestation hypermanesemia

                                                        System hypermanesemia

                                                        Gastrointestinal Nauseavomiting

                                                        Neuromuscular weakness lethargy Decreased

                                                        reflexes

                                                        Cardiovascular Hypotension arrest

                                                        ECG changes Increased PR interval

                                                        Widened QRS complex

                                                        Elevated T waves

                                                        Treatment

                                                        1 Withhold exogenous sources of magnesium

                                                        2 Correct volume deficit

                                                        3 Correct acidosis if present

                                                        4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                        5 Dialysis (if elevated levels or symptoms persist)

                                                        عالئم

                                                        bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                        meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                        meqL

                                                        Hypomagnesemia

                                                        Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                        homeostasis

                                                        Etiology

                                                        1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                        inadequate supplementation of magnesium)

                                                        2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                        3 GI losses (diarrhea)

                                                        4 Malabsorption

                                                        5 Acute pancreatitis

                                                        6 Diabetic ketoacidosis

                                                        7 Primary aldosteronism

                                                        Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                        1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                        2 Delirium and seizures in severe deficiency

                                                        3 ECG changes Prolonged QT and PR interval

                                                        ST-segment depression

                                                        Flattening or inversion of P waves

                                                        Torsades de pointes

                                                        Arrhythmia

                                                        Treatment

                                                        1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                        2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                        Message for Today

                                                        ICF

                                                        Interstitial

                                                        Pla

                                                        sma

                                                        5 Dex

                                                        bull Do not reccussitate sick patients with any Dextrose solution

                                                        • Fluid and Electrolyte Management of the Surgical Patient
                                                        • Slide 2
                                                        • Slide 3
                                                        • Slide 4
                                                        • Total Body Water
                                                        • Body Fluid Compartments
                                                        • Total body water (TBW)
                                                        • Body compartment fluid
                                                        • Example men with 70kg
                                                        • Fluid compartments
                                                        • Slide 11
                                                        • Slide 12
                                                        • Slide 13
                                                        • Slide 14
                                                        • Slide 15
                                                        • Colloid osmotic pressure
                                                        • Slide 17
                                                        • Slide 18
                                                        • Slide 19
                                                        • Cell Membrane
                                                        • Slide 21
                                                        • Slide 22
                                                        • Slide 23
                                                        • Slide 24
                                                        • Slide 25
                                                        • Composition of Fluid Compartments
                                                        • Composition of Body Fluids
                                                        • عوامل موثر روی تغییرات آب والکترولیت
                                                        • Reasons for fluid therapy
                                                        • ارزیابی حجم مایع داخل عروقی
                                                        • محلولهای وریدی
                                                        • Fluids
                                                        • Slide 33
                                                        • Slide 34
                                                        • Slide 35
                                                        • Crystalloids
                                                        • Colloid Solutions
                                                        • رینگر لاکتات
                                                        • 09Nacl
                                                        • Postoperative (maintenance)
                                                        • Slide 41
                                                        • Preexisting fluid deficits
                                                        • Maintenance requirements
                                                        • Surgical fluid losses
                                                        • Third space loss
                                                        • Crystalloid solution
                                                        • Colloids
                                                        • Complications
                                                        • The Influence of Colloid amp Crystalloid on Blood Volume
                                                        • Colloid versus crystalloid solutions
                                                        • Transfusion consideration
                                                        • اختلال در حجم مایعات بدن
                                                        • Fluid volume deficit (FVD)
                                                        • DEHYDRATION
                                                        • علل کاهش حجم خارج سلولی
                                                        • Signs of Hypovolemia
                                                        • Clinical Diagnosis of Hypovolemia
                                                        • Signs of Hypervolemia
                                                        • Management of Hypervolemia
                                                        • Fluid Management
                                                        • Electrolyte physiology
                                                        • Sodium physiology
                                                        • Osmotic Pressure
                                                        • Concentration
                                                        • Hypernatremia
                                                        • - Hypernatremia
                                                        • Slide 67
                                                        • Slide 68
                                                        • Clinical Manifestations of Abnormalities in Serum Sodium
                                                        • Treatment
                                                        • Water deficit (L)= times TBW
                                                        • The rate of fluid administration
                                                        • Hyponatremia Nalt135mEqL
                                                        • Slide 74
                                                        • Sodium depletion
                                                        • Sodium dilution
                                                        • Sign and symptoms
                                                        • Slide 78
                                                        • Treatment
                                                        • Slide 80
                                                        • Slide 81
                                                        • Dose
                                                        • Potassium abnormalities
                                                        • Hyperkalemia
                                                        • Clinical manifestation of hyperkalemia
                                                        • Slide 86
                                                        • Slide 87
                                                        • Hypokalemia
                                                        • Potassium changes associated with alkalosis
                                                        • Slide 90
                                                        • Clinical Manifestation of Abnormalities in potassium
                                                        • Slide 92
                                                        • Calcium
                                                        • هيپوكلسمي یونیزه Calt45 meql
                                                        • علائم هیپوکلسمی
                                                        • Slide 96
                                                        • Slide 97
                                                        • Slide 98
                                                        • Slide 99
                                                        • سایرعلائم
                                                        • درمان
                                                        • هيپركلسمي Cagt55meql
                                                        • علائم
                                                        • علائم قلبی
                                                        • Slide 105
                                                        • Magnesium Abnormalities
                                                        • منیزیوم
                                                        • Hypermagnesemia
                                                        • Clinical manifestation hypermanesemia
                                                        • Slide 110
                                                        • Slide 111
                                                        • Hypomagnesemia
                                                        • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                        • Slide 114
                                                        • Message for Today
                                                        • Slide 116

                                                          Reasons for fluid therapyReasons for fluid therapy

                                                          Preserve oxygen delivery to tissuesPreserve oxygen delivery to tissues

                                                          bull Correct hypovolaemiaCorrect hypovolaemia

                                                          bull Maintain cardiac outputMaintain cardiac output

                                                          bull Optimise gas exchangeOptimise gas exchange

                                                          bull Replace electrolytes amp waterReplace electrolytes amp water

                                                          bull Maintain urine outputMaintain urine output

                                                          Colloids + RBCs

                                                          Crystalloids

                                                          Identify what is the goal

                                                          Choose fluid which best achieves the goal

                                                          عروقی داخل مایع حجم ارزیابی

                                                          بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                                                          وریدی محلولهای

                                                          Fluids bull Crystalloids

                                                          bull Colloids

                                                          bull blood

                                                          Which of the following solutions is isotonic

                                                          A D5W

                                                          B 045 saline

                                                          C 09 saline

                                                          D D5 in 09 saline

                                                          SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                                                          ECFECF 142 4 5 103 27 280-310

                                                          Lactated Lactated RingerrsquosRingerrsquos

                                                          130 4 3 109 28 273

                                                          09 NaCl09 NaCl 154 154 308

                                                          045 045 NaClNaCl

                                                          77 77 154

                                                          D5WD5W

                                                          D5045 D5045 NaClNaCl

                                                          77 77 50 406

                                                          3 NaCl3 NaCl 513 513 1026

                                                          6 6 HetastarchHetastarch

                                                          500 154 154 310

                                                          5 5 AlbuminAlbumin

                                                          250500130-160

                                                          lt25130-160

                                                          330

                                                          25 25 AlbuminAlbumin

                                                          2050100130-160

                                                          lt25130-160

                                                          330

                                                          Common parenteral fluid therapyCommon parenteral fluid therapy

                                                          CrystalloidsCrystalloids

                                                          bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                                          Colloid SolutionsColloid Solutions

                                                          bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                                          - Haes-steril 10

                                                          الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                                          کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                                          ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                                          osm=273

                                                          09Nacl

                                                          bull Na=154

                                                          bull CL= 154

                                                          کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                                          PH=56است

                                                          Postoperative (maintenance)

                                                          045Nacl +5 dextrose +KCL

                                                          Perioperative management of fluid balance include

                                                          1 Preoperative evaluation

                                                          2 Intraoperative maintenance

                                                          3 Replacement of fluid losses

                                                          Preexisting fluid deficits

                                                          bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                                          bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                                          Maintenance requirements

                                                          bull Up to 10 kg = 4cckghr

                                                          bull 11-20kg = add 2cckghr

                                                          bull 21kg and above = add 1cckghr

                                                          bull Insensible losses = 2cckghr

                                                          Surgical fluid losses

                                                          Blood loss (measurement)

                                                          1 Suction container

                                                          2 Surgical sponge

                                                          3 Hct and tachycardia not specific

                                                          4 ABG and UO if hypoperfusion occur

                                                          5 Blood loss=31 with crystalloid

                                                          Other losses (third space loss)

                                                          Third space loss

                                                          1 Minimal (herniorrapy) =2-4cckghr

                                                          2 Moderate (cholecystectomy)=4-6cckghr

                                                          3 Severe (bowel resection) = 6-8cckghr

                                                          Crystalloid solution

                                                          1 The main solutions is either glucose or saline

                                                          2 Hypotonic or isotonic or hypertonic

                                                          3 Safe nontoxic reaction free inexpensive

                                                          4 Complication is edema if large volumes are needed

                                                          5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                          Colloids

                                                          1 Albumin

                                                          2 Hydroxyethyl starch

                                                          3 Dextran

                                                          Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                          factor )These colloid is best avoided in patients with

                                                          coagulopaty

                                                          The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                          1000cc

                                                          500cc

                                                          500cc

                                                          500cc

                                                          200

                                                          600

                                                          1000

                                                          Lactated Ringers

                                                          5 Albumin

                                                          6 Hetastarch

                                                          Whole blood

                                                          Blood volumeInfusion volume

                                                          Colloid versus crystalloid solutions

                                                          Transfusion consideration

                                                          bull HB lt7 mg dl increase CO

                                                          bull Ideal Hb is 7-8 mgdl

                                                          bull In IHD patients or pulmonary disease gt 10 mgdl

                                                          بدن مایعات حجم در اختالل

                                                          1 Fluid volume deficit

                                                          2 Fluid volume excess

                                                          Fluid volume deficit(FVD)

                                                          ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                          کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                          ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                          باشد آن با همراه دیگری اختالل مگر

                                                          DEHYDRATION

                                                          سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                          سلولی خارج حجم کاهش علل

                                                          1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                          2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                          کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                          Signs of HypovolemiaSigns of Hypovolemia

                                                          bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                          Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                          bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                          Signs of HypervolemiaSigns of Hypervolemia

                                                          bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                          Especially when hypo-albuminemia

                                                          Management of Management of HypervolemiaHypervolemia

                                                          bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                          Fluid ManagementFluid Management

                                                          bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                          Electrolyte physiology

                                                          Sodium physiology

                                                          Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                          Normal amount 135-145 meql

                                                          Osmotic Pressure

                                                          Calculated serum osmolality =

                                                          2 sodium+ glucose18 + BUN 28

                                                          Osmolality = 290 mosm

                                                          Concentration

                                                          1Serum sodium concentration2Serum osmolarity

                                                          bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                          drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                          DW5)

                                                          Hypernatremia

                                                          Serum Nagt145mEqL

                                                          - Hypernatremia

                                                          Loss of Free Water

                                                          Gain of sodium in excess of water

                                                          Hypernatremia

                                                          -Hypernatremia Hypo volemic

                                                          Hyper volemic

                                                          Normo volemic

                                                          Hypernatremia

                                                          Volume Status

                                                          Normal

                                                          Nonrenal water loss

                                                          Skin

                                                          Gastrointestinal

                                                          Renal water loss

                                                          Renal disease

                                                          Diuretics

                                                          Diabetes insipidus

                                                          High

                                                          Iatrogenic sodium administration

                                                          Mineralocorticoid excess

                                                          Aldosteronism

                                                          Cushingrsquos disease

                                                          Congenital adrenal

                                                          hyperplasia

                                                          Low

                                                          Nonrenal water loss

                                                          Skin

                                                          Gastrointestinal losses

                                                          Renal water losses

                                                          Renal (tubular) Diuretics

                                                          Osmotic diuretics

                                                          Diabetes insipidus

                                                          Adrenal failure

                                                          Asymptomatic

                                                          Hypernatremia Symptomatic (Nagt160 meqL)

                                                          Clinical Manifestations of Abnormalities in Serum Sodium

                                                          Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                          Body system hypernatremia

                                                          Treatment

                                                          Normal saline in hypovolemic patients

                                                          Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                          saline or entral water)

                                                          Water deficit (L)= times TBW

                                                          The formula used to estimate the amount of water required to correct hypernatremia

                                                          Estimate TBW as 55 of lean body mass in men and 45 in women

                                                          Serum sodium-140

                                                          140

                                                          The rate of fluid administration

                                                          1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                          2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                          Hyponatremia Nalt135mEqL

                                                          Causes

                                                          1 Sodium depletion

                                                          2 Sodium dilution

                                                          bull Incidence = 45

                                                          bull After surgery=1

                                                          bull Mortality = 2 times normal

                                                          Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                          volume deficit

                                                          Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                          Sign and symptoms

                                                          bull CNS symptom when Nalt123 meql

                                                          bull Cardiac symptom when Nalt100 meql

                                                          For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                          Body System Hyponatremia

                                                          central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                          reflexes seizures coma increased intracranial pressure

                                                          Musculoskeletal Weakness fatigue muscle crampstwitching

                                                          Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                          Cardiovascular Hypertension and bradycardia if significant increases in

                                                          intracranial pressure

                                                          Tissue Lacrimation salivation

                                                          Renal Oliguria

                                                          Clinical Manifestations of Abnormalities in Serum Sodium

                                                          Treatment

                                                          1=Depend on ECF

                                                          2=CNS sign

                                                          Treatment

                                                          1 Asymptomatic increase the sodium level by no more than

                                                          05-1 meqLh to a maximum increase of 12 meqL per day

                                                          2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                          more than 1meqL per hour until the serum Na level reaches 130

                                                          meqL or neurologic symptoms are improved

                                                          Rapid correction of hyponatremia

                                                          Pontine myelinolysis

                                                          Seizures weaknessparesis akinetic

                                                          movements unresponsiveness

                                                          Permanent brain damage

                                                          Death

                                                          Dose

                                                          Na deficit meq =(140- Na meql) TBW

                                                          باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                          شود اصالح آهسته سپس

                                                          Potassium abnormalities

                                                          bull The average dietary intake of potassium 50-100meqd

                                                          bull The average renal excretion of potassium 10-700 meqd

                                                          - 2 of the total body potassium in ECF (45meqL)

                                                          - Factors that influence serum potassium

                                                          1 Surgical stress

                                                          2 Injury

                                                          3 Acidosis

                                                          4 Tissue catabolism

                                                          Hyperkalemia

                                                          The normal range of serum potassium 35-5 meqL

                                                          Etiology of Hyperkalemia

                                                          Increased intake Potassium supplementation

                                                          Blood transfusions

                                                          Endogenous loaddestruction

                                                          hemolysis rhabdomyolysis

                                                          cruch injury gastrointestinal hemorrhage

                                                          Increased release Acidosis

                                                          Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                          Renal insufficiencyfailure

                                                          Clinical manifestation of hyperkalemia

                                                          System hyperkalemia

                                                          Gastrointestinal Nauseavomiting colic diarrhea

                                                          Neuromuscular weakness paralysis respiratory failure

                                                          Cardiovascular Arrhythmia arrest

                                                          ECG changes Peaked T waves (early change)

                                                          Flattened P wave

                                                          Prolonged PR interval (first-degree block)

                                                          Widened QRS complex

                                                          Sine wave formation

                                                          Ventricular fibrillation

                                                          Treatment

                                                          Treatment of symptomatic hyperkalemia

                                                          Potassium removal Kayexalate

                                                          Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                          Rectal administration is 50 g in 200 mL 20 sorbitol

                                                          Dialysis

                                                          Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                          Bicarbonate 1 vial intravenous

                                                          Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                          HypokalemiaEtiology

                                                          inadequate intake

                                                          Dietary potassium-free intravenous fluids potassium-deficient

                                                          total parenteral nutrition

                                                          Excessive potassium excretion

                                                          Hyperaldosteronism

                                                          Medications

                                                          Gastrointestinal losses

                                                          Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                          Renal loss of potassium (gastric fluid either as vomiting or high

                                                          nasogastric output)

                                                          Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                          Potassium changes associated with alkalosis

                                                          Potassium decrease by 03 meqL for every 01

                                                          increase in PH above normal

                                                          Magnesium Depletion

                                                          (drug induced amphotericin amioglycosides cisplatin)

                                                          Renal potassium wastage

                                                          Hypokalemia

                                                          Magnesium Depletion

                                                          (drug induced amphotericin amioglycosides cisplatin)

                                                          Renal potassium wastage

                                                          Hypokalemia

                                                          Clinical Manifestation of Abnormalities in potassium

                                                          System hypokalemia

                                                          Gastrointestinal Ileus constipation

                                                          Neuromuscular Decreased reflexes fatigue weakness

                                                          paralysis

                                                          Cardiovascular Arrest

                                                          ECG changes U-waves

                                                          T-wave flattening

                                                          ST-segment changes

                                                          Arrhythmias

                                                          Treatment

                                                          Potassium

                                                          Serum potassium level lt40 mEqL

                                                          Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                          times 1 doses

                                                          Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                          Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                          Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                          asymptomatic replace as per above protocol

                                                          Electrolyte Replacement Therapy Protocol

                                                          bull Oral repletion for mild and asymptomatic hypokalemia

                                                          bull IV repletion for severe and symptomatic hypokalemia

                                                          Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                          ( دندانها( ndash استخوانbull كلسيم نقش

                                                          عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                          صاف 2 عضالت انقباض

                                                          هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                          انعقاد 4

                                                          یونیزه Calt45 meql هيپوكلسمي

                                                          عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                          ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                          میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                          ( شود می پیوند شده

                                                          هیپوکلسمی عالئم

                                                          رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                          سایرعالئم

                                                          قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                          درمان

                                                          ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                          Cagt55meql هيپركلسمي

                                                          هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                          عالئم

                                                          bullGI

                                                          bullCardiovascular bullRenal (polyuria)

                                                          bullCNS

                                                          قلبی عالئم

                                                          bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                          QRS شدن )Q-Tوكوتاه

                                                          درمان

                                                          ایزوتونیک 1 نمکی محلول انفوزیون

                                                          الزیکس2

                                                          تونین 3 کلسی

                                                          کورتون4

                                                          دیالیز5

                                                          Magnesium Abnormalities

                                                          Normal dietary intake 20meq (240mg)

                                                          Excretion in both the feces and urine

                                                          Normal serum level 19-25 mgdL

                                                          منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                          تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                          bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                          Hypermagnesemia

                                                          Etiology

                                                          1 Impaired renal function

                                                          2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                          Clinical manifestation hypermanesemia

                                                          System hypermanesemia

                                                          Gastrointestinal Nauseavomiting

                                                          Neuromuscular weakness lethargy Decreased

                                                          reflexes

                                                          Cardiovascular Hypotension arrest

                                                          ECG changes Increased PR interval

                                                          Widened QRS complex

                                                          Elevated T waves

                                                          Treatment

                                                          1 Withhold exogenous sources of magnesium

                                                          2 Correct volume deficit

                                                          3 Correct acidosis if present

                                                          4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                          5 Dialysis (if elevated levels or symptoms persist)

                                                          عالئم

                                                          bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                          meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                          meqL

                                                          Hypomagnesemia

                                                          Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                          homeostasis

                                                          Etiology

                                                          1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                          inadequate supplementation of magnesium)

                                                          2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                          3 GI losses (diarrhea)

                                                          4 Malabsorption

                                                          5 Acute pancreatitis

                                                          6 Diabetic ketoacidosis

                                                          7 Primary aldosteronism

                                                          Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                          1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                          2 Delirium and seizures in severe deficiency

                                                          3 ECG changes Prolonged QT and PR interval

                                                          ST-segment depression

                                                          Flattening or inversion of P waves

                                                          Torsades de pointes

                                                          Arrhythmia

                                                          Treatment

                                                          1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                          2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                          Message for Today

                                                          ICF

                                                          Interstitial

                                                          Pla

                                                          sma

                                                          5 Dex

                                                          bull Do not reccussitate sick patients with any Dextrose solution

                                                          • Fluid and Electrolyte Management of the Surgical Patient
                                                          • Slide 2
                                                          • Slide 3
                                                          • Slide 4
                                                          • Total Body Water
                                                          • Body Fluid Compartments
                                                          • Total body water (TBW)
                                                          • Body compartment fluid
                                                          • Example men with 70kg
                                                          • Fluid compartments
                                                          • Slide 11
                                                          • Slide 12
                                                          • Slide 13
                                                          • Slide 14
                                                          • Slide 15
                                                          • Colloid osmotic pressure
                                                          • Slide 17
                                                          • Slide 18
                                                          • Slide 19
                                                          • Cell Membrane
                                                          • Slide 21
                                                          • Slide 22
                                                          • Slide 23
                                                          • Slide 24
                                                          • Slide 25
                                                          • Composition of Fluid Compartments
                                                          • Composition of Body Fluids
                                                          • عوامل موثر روی تغییرات آب والکترولیت
                                                          • Reasons for fluid therapy
                                                          • ارزیابی حجم مایع داخل عروقی
                                                          • محلولهای وریدی
                                                          • Fluids
                                                          • Slide 33
                                                          • Slide 34
                                                          • Slide 35
                                                          • Crystalloids
                                                          • Colloid Solutions
                                                          • رینگر لاکتات
                                                          • 09Nacl
                                                          • Postoperative (maintenance)
                                                          • Slide 41
                                                          • Preexisting fluid deficits
                                                          • Maintenance requirements
                                                          • Surgical fluid losses
                                                          • Third space loss
                                                          • Crystalloid solution
                                                          • Colloids
                                                          • Complications
                                                          • The Influence of Colloid amp Crystalloid on Blood Volume
                                                          • Colloid versus crystalloid solutions
                                                          • Transfusion consideration
                                                          • اختلال در حجم مایعات بدن
                                                          • Fluid volume deficit (FVD)
                                                          • DEHYDRATION
                                                          • علل کاهش حجم خارج سلولی
                                                          • Signs of Hypovolemia
                                                          • Clinical Diagnosis of Hypovolemia
                                                          • Signs of Hypervolemia
                                                          • Management of Hypervolemia
                                                          • Fluid Management
                                                          • Electrolyte physiology
                                                          • Sodium physiology
                                                          • Osmotic Pressure
                                                          • Concentration
                                                          • Hypernatremia
                                                          • - Hypernatremia
                                                          • Slide 67
                                                          • Slide 68
                                                          • Clinical Manifestations of Abnormalities in Serum Sodium
                                                          • Treatment
                                                          • Water deficit (L)= times TBW
                                                          • The rate of fluid administration
                                                          • Hyponatremia Nalt135mEqL
                                                          • Slide 74
                                                          • Sodium depletion
                                                          • Sodium dilution
                                                          • Sign and symptoms
                                                          • Slide 78
                                                          • Treatment
                                                          • Slide 80
                                                          • Slide 81
                                                          • Dose
                                                          • Potassium abnormalities
                                                          • Hyperkalemia
                                                          • Clinical manifestation of hyperkalemia
                                                          • Slide 86
                                                          • Slide 87
                                                          • Hypokalemia
                                                          • Potassium changes associated with alkalosis
                                                          • Slide 90
                                                          • Clinical Manifestation of Abnormalities in potassium
                                                          • Slide 92
                                                          • Calcium
                                                          • هيپوكلسمي یونیزه Calt45 meql
                                                          • علائم هیپوکلسمی
                                                          • Slide 96
                                                          • Slide 97
                                                          • Slide 98
                                                          • Slide 99
                                                          • سایرعلائم
                                                          • درمان
                                                          • هيپركلسمي Cagt55meql
                                                          • علائم
                                                          • علائم قلبی
                                                          • Slide 105
                                                          • Magnesium Abnormalities
                                                          • منیزیوم
                                                          • Hypermagnesemia
                                                          • Clinical manifestation hypermanesemia
                                                          • Slide 110
                                                          • Slide 111
                                                          • Hypomagnesemia
                                                          • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                          • Slide 114
                                                          • Message for Today
                                                          • Slide 116

                                                            عروقی داخل مایع حجم ارزیابی

                                                            بیمار bull حال شرحخوابیده ) ndash (bull ایستاده خون فشاربیمار bull قلب ضربانادراری bull ده برونهماتوکریتbullخون bull نیتروژنها bull الکترولیتbullABGbullCVP

                                                            وریدی محلولهای

                                                            Fluids bull Crystalloids

                                                            bull Colloids

                                                            bull blood

                                                            Which of the following solutions is isotonic

                                                            A D5W

                                                            B 045 saline

                                                            C 09 saline

                                                            D D5 in 09 saline

                                                            SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                                                            ECFECF 142 4 5 103 27 280-310

                                                            Lactated Lactated RingerrsquosRingerrsquos

                                                            130 4 3 109 28 273

                                                            09 NaCl09 NaCl 154 154 308

                                                            045 045 NaClNaCl

                                                            77 77 154

                                                            D5WD5W

                                                            D5045 D5045 NaClNaCl

                                                            77 77 50 406

                                                            3 NaCl3 NaCl 513 513 1026

                                                            6 6 HetastarchHetastarch

                                                            500 154 154 310

                                                            5 5 AlbuminAlbumin

                                                            250500130-160

                                                            lt25130-160

                                                            330

                                                            25 25 AlbuminAlbumin

                                                            2050100130-160

                                                            lt25130-160

                                                            330

                                                            Common parenteral fluid therapyCommon parenteral fluid therapy

                                                            CrystalloidsCrystalloids

                                                            bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                                            Colloid SolutionsColloid Solutions

                                                            bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                                            - Haes-steril 10

                                                            الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                                            کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                                            ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                                            osm=273

                                                            09Nacl

                                                            bull Na=154

                                                            bull CL= 154

                                                            کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                                            PH=56است

                                                            Postoperative (maintenance)

                                                            045Nacl +5 dextrose +KCL

                                                            Perioperative management of fluid balance include

                                                            1 Preoperative evaluation

                                                            2 Intraoperative maintenance

                                                            3 Replacement of fluid losses

                                                            Preexisting fluid deficits

                                                            bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                                            bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                                            Maintenance requirements

                                                            bull Up to 10 kg = 4cckghr

                                                            bull 11-20kg = add 2cckghr

                                                            bull 21kg and above = add 1cckghr

                                                            bull Insensible losses = 2cckghr

                                                            Surgical fluid losses

                                                            Blood loss (measurement)

                                                            1 Suction container

                                                            2 Surgical sponge

                                                            3 Hct and tachycardia not specific

                                                            4 ABG and UO if hypoperfusion occur

                                                            5 Blood loss=31 with crystalloid

                                                            Other losses (third space loss)

                                                            Third space loss

                                                            1 Minimal (herniorrapy) =2-4cckghr

                                                            2 Moderate (cholecystectomy)=4-6cckghr

                                                            3 Severe (bowel resection) = 6-8cckghr

                                                            Crystalloid solution

                                                            1 The main solutions is either glucose or saline

                                                            2 Hypotonic or isotonic or hypertonic

                                                            3 Safe nontoxic reaction free inexpensive

                                                            4 Complication is edema if large volumes are needed

                                                            5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                            Colloids

                                                            1 Albumin

                                                            2 Hydroxyethyl starch

                                                            3 Dextran

                                                            Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                            factor )These colloid is best avoided in patients with

                                                            coagulopaty

                                                            The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                            1000cc

                                                            500cc

                                                            500cc

                                                            500cc

                                                            200

                                                            600

                                                            1000

                                                            Lactated Ringers

                                                            5 Albumin

                                                            6 Hetastarch

                                                            Whole blood

                                                            Blood volumeInfusion volume

                                                            Colloid versus crystalloid solutions

                                                            Transfusion consideration

                                                            bull HB lt7 mg dl increase CO

                                                            bull Ideal Hb is 7-8 mgdl

                                                            bull In IHD patients or pulmonary disease gt 10 mgdl

                                                            بدن مایعات حجم در اختالل

                                                            1 Fluid volume deficit

                                                            2 Fluid volume excess

                                                            Fluid volume deficit(FVD)

                                                            ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                            کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                            ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                            باشد آن با همراه دیگری اختالل مگر

                                                            DEHYDRATION

                                                            سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                            سلولی خارج حجم کاهش علل

                                                            1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                            2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                            کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                            Signs of HypovolemiaSigns of Hypovolemia

                                                            bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                            Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                            bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                            Signs of HypervolemiaSigns of Hypervolemia

                                                            bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                            Especially when hypo-albuminemia

                                                            Management of Management of HypervolemiaHypervolemia

                                                            bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                            Fluid ManagementFluid Management

                                                            bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                            Electrolyte physiology

                                                            Sodium physiology

                                                            Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                            Normal amount 135-145 meql

                                                            Osmotic Pressure

                                                            Calculated serum osmolality =

                                                            2 sodium+ glucose18 + BUN 28

                                                            Osmolality = 290 mosm

                                                            Concentration

                                                            1Serum sodium concentration2Serum osmolarity

                                                            bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                            drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                            DW5)

                                                            Hypernatremia

                                                            Serum Nagt145mEqL

                                                            - Hypernatremia

                                                            Loss of Free Water

                                                            Gain of sodium in excess of water

                                                            Hypernatremia

                                                            -Hypernatremia Hypo volemic

                                                            Hyper volemic

                                                            Normo volemic

                                                            Hypernatremia

                                                            Volume Status

                                                            Normal

                                                            Nonrenal water loss

                                                            Skin

                                                            Gastrointestinal

                                                            Renal water loss

                                                            Renal disease

                                                            Diuretics

                                                            Diabetes insipidus

                                                            High

                                                            Iatrogenic sodium administration

                                                            Mineralocorticoid excess

                                                            Aldosteronism

                                                            Cushingrsquos disease

                                                            Congenital adrenal

                                                            hyperplasia

                                                            Low

                                                            Nonrenal water loss

                                                            Skin

                                                            Gastrointestinal losses

                                                            Renal water losses

                                                            Renal (tubular) Diuretics

                                                            Osmotic diuretics

                                                            Diabetes insipidus

                                                            Adrenal failure

                                                            Asymptomatic

                                                            Hypernatremia Symptomatic (Nagt160 meqL)

                                                            Clinical Manifestations of Abnormalities in Serum Sodium

                                                            Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                            Body system hypernatremia

                                                            Treatment

                                                            Normal saline in hypovolemic patients

                                                            Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                            saline or entral water)

                                                            Water deficit (L)= times TBW

                                                            The formula used to estimate the amount of water required to correct hypernatremia

                                                            Estimate TBW as 55 of lean body mass in men and 45 in women

                                                            Serum sodium-140

                                                            140

                                                            The rate of fluid administration

                                                            1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                            2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                            Hyponatremia Nalt135mEqL

                                                            Causes

                                                            1 Sodium depletion

                                                            2 Sodium dilution

                                                            bull Incidence = 45

                                                            bull After surgery=1

                                                            bull Mortality = 2 times normal

                                                            Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                            volume deficit

                                                            Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                            Sign and symptoms

                                                            bull CNS symptom when Nalt123 meql

                                                            bull Cardiac symptom when Nalt100 meql

                                                            For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                            Body System Hyponatremia

                                                            central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                            reflexes seizures coma increased intracranial pressure

                                                            Musculoskeletal Weakness fatigue muscle crampstwitching

                                                            Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                            Cardiovascular Hypertension and bradycardia if significant increases in

                                                            intracranial pressure

                                                            Tissue Lacrimation salivation

                                                            Renal Oliguria

                                                            Clinical Manifestations of Abnormalities in Serum Sodium

                                                            Treatment

                                                            1=Depend on ECF

                                                            2=CNS sign

                                                            Treatment

                                                            1 Asymptomatic increase the sodium level by no more than

                                                            05-1 meqLh to a maximum increase of 12 meqL per day

                                                            2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                            more than 1meqL per hour until the serum Na level reaches 130

                                                            meqL or neurologic symptoms are improved

                                                            Rapid correction of hyponatremia

                                                            Pontine myelinolysis

                                                            Seizures weaknessparesis akinetic

                                                            movements unresponsiveness

                                                            Permanent brain damage

                                                            Death

                                                            Dose

                                                            Na deficit meq =(140- Na meql) TBW

                                                            باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                            شود اصالح آهسته سپس

                                                            Potassium abnormalities

                                                            bull The average dietary intake of potassium 50-100meqd

                                                            bull The average renal excretion of potassium 10-700 meqd

                                                            - 2 of the total body potassium in ECF (45meqL)

                                                            - Factors that influence serum potassium

                                                            1 Surgical stress

                                                            2 Injury

                                                            3 Acidosis

                                                            4 Tissue catabolism

                                                            Hyperkalemia

                                                            The normal range of serum potassium 35-5 meqL

                                                            Etiology of Hyperkalemia

                                                            Increased intake Potassium supplementation

                                                            Blood transfusions

                                                            Endogenous loaddestruction

                                                            hemolysis rhabdomyolysis

                                                            cruch injury gastrointestinal hemorrhage

                                                            Increased release Acidosis

                                                            Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                            Renal insufficiencyfailure

                                                            Clinical manifestation of hyperkalemia

                                                            System hyperkalemia

                                                            Gastrointestinal Nauseavomiting colic diarrhea

                                                            Neuromuscular weakness paralysis respiratory failure

                                                            Cardiovascular Arrhythmia arrest

                                                            ECG changes Peaked T waves (early change)

                                                            Flattened P wave

                                                            Prolonged PR interval (first-degree block)

                                                            Widened QRS complex

                                                            Sine wave formation

                                                            Ventricular fibrillation

                                                            Treatment

                                                            Treatment of symptomatic hyperkalemia

                                                            Potassium removal Kayexalate

                                                            Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                            Rectal administration is 50 g in 200 mL 20 sorbitol

                                                            Dialysis

                                                            Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                            Bicarbonate 1 vial intravenous

                                                            Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                            HypokalemiaEtiology

                                                            inadequate intake

                                                            Dietary potassium-free intravenous fluids potassium-deficient

                                                            total parenteral nutrition

                                                            Excessive potassium excretion

                                                            Hyperaldosteronism

                                                            Medications

                                                            Gastrointestinal losses

                                                            Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                            Renal loss of potassium (gastric fluid either as vomiting or high

                                                            nasogastric output)

                                                            Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                            Potassium changes associated with alkalosis

                                                            Potassium decrease by 03 meqL for every 01

                                                            increase in PH above normal

                                                            Magnesium Depletion

                                                            (drug induced amphotericin amioglycosides cisplatin)

                                                            Renal potassium wastage

                                                            Hypokalemia

                                                            Magnesium Depletion

                                                            (drug induced amphotericin amioglycosides cisplatin)

                                                            Renal potassium wastage

                                                            Hypokalemia

                                                            Clinical Manifestation of Abnormalities in potassium

                                                            System hypokalemia

                                                            Gastrointestinal Ileus constipation

                                                            Neuromuscular Decreased reflexes fatigue weakness

                                                            paralysis

                                                            Cardiovascular Arrest

                                                            ECG changes U-waves

                                                            T-wave flattening

                                                            ST-segment changes

                                                            Arrhythmias

                                                            Treatment

                                                            Potassium

                                                            Serum potassium level lt40 mEqL

                                                            Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                            times 1 doses

                                                            Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                            Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                            Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                            asymptomatic replace as per above protocol

                                                            Electrolyte Replacement Therapy Protocol

                                                            bull Oral repletion for mild and asymptomatic hypokalemia

                                                            bull IV repletion for severe and symptomatic hypokalemia

                                                            Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                            ( دندانها( ndash استخوانbull كلسيم نقش

                                                            عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                            صاف 2 عضالت انقباض

                                                            هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                            انعقاد 4

                                                            یونیزه Calt45 meql هيپوكلسمي

                                                            عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                            ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                            میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                            ( شود می پیوند شده

                                                            هیپوکلسمی عالئم

                                                            رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                            سایرعالئم

                                                            قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                            درمان

                                                            ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                            Cagt55meql هيپركلسمي

                                                            هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                            عالئم

                                                            bullGI

                                                            bullCardiovascular bullRenal (polyuria)

                                                            bullCNS

                                                            قلبی عالئم

                                                            bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                            QRS شدن )Q-Tوكوتاه

                                                            درمان

                                                            ایزوتونیک 1 نمکی محلول انفوزیون

                                                            الزیکس2

                                                            تونین 3 کلسی

                                                            کورتون4

                                                            دیالیز5

                                                            Magnesium Abnormalities

                                                            Normal dietary intake 20meq (240mg)

                                                            Excretion in both the feces and urine

                                                            Normal serum level 19-25 mgdL

                                                            منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                            تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                            bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                            Hypermagnesemia

                                                            Etiology

                                                            1 Impaired renal function

                                                            2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                            Clinical manifestation hypermanesemia

                                                            System hypermanesemia

                                                            Gastrointestinal Nauseavomiting

                                                            Neuromuscular weakness lethargy Decreased

                                                            reflexes

                                                            Cardiovascular Hypotension arrest

                                                            ECG changes Increased PR interval

                                                            Widened QRS complex

                                                            Elevated T waves

                                                            Treatment

                                                            1 Withhold exogenous sources of magnesium

                                                            2 Correct volume deficit

                                                            3 Correct acidosis if present

                                                            4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                            5 Dialysis (if elevated levels or symptoms persist)

                                                            عالئم

                                                            bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                            meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                            meqL

                                                            Hypomagnesemia

                                                            Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                            homeostasis

                                                            Etiology

                                                            1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                            inadequate supplementation of magnesium)

                                                            2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                            3 GI losses (diarrhea)

                                                            4 Malabsorption

                                                            5 Acute pancreatitis

                                                            6 Diabetic ketoacidosis

                                                            7 Primary aldosteronism

                                                            Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                            1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                            2 Delirium and seizures in severe deficiency

                                                            3 ECG changes Prolonged QT and PR interval

                                                            ST-segment depression

                                                            Flattening or inversion of P waves

                                                            Torsades de pointes

                                                            Arrhythmia

                                                            Treatment

                                                            1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                            2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                            Message for Today

                                                            ICF

                                                            Interstitial

                                                            Pla

                                                            sma

                                                            5 Dex

                                                            bull Do not reccussitate sick patients with any Dextrose solution

                                                            • Fluid and Electrolyte Management of the Surgical Patient
                                                            • Slide 2
                                                            • Slide 3
                                                            • Slide 4
                                                            • Total Body Water
                                                            • Body Fluid Compartments
                                                            • Total body water (TBW)
                                                            • Body compartment fluid
                                                            • Example men with 70kg
                                                            • Fluid compartments
                                                            • Slide 11
                                                            • Slide 12
                                                            • Slide 13
                                                            • Slide 14
                                                            • Slide 15
                                                            • Colloid osmotic pressure
                                                            • Slide 17
                                                            • Slide 18
                                                            • Slide 19
                                                            • Cell Membrane
                                                            • Slide 21
                                                            • Slide 22
                                                            • Slide 23
                                                            • Slide 24
                                                            • Slide 25
                                                            • Composition of Fluid Compartments
                                                            • Composition of Body Fluids
                                                            • عوامل موثر روی تغییرات آب والکترولیت
                                                            • Reasons for fluid therapy
                                                            • ارزیابی حجم مایع داخل عروقی
                                                            • محلولهای وریدی
                                                            • Fluids
                                                            • Slide 33
                                                            • Slide 34
                                                            • Slide 35
                                                            • Crystalloids
                                                            • Colloid Solutions
                                                            • رینگر لاکتات
                                                            • 09Nacl
                                                            • Postoperative (maintenance)
                                                            • Slide 41
                                                            • Preexisting fluid deficits
                                                            • Maintenance requirements
                                                            • Surgical fluid losses
                                                            • Third space loss
                                                            • Crystalloid solution
                                                            • Colloids
                                                            • Complications
                                                            • The Influence of Colloid amp Crystalloid on Blood Volume
                                                            • Colloid versus crystalloid solutions
                                                            • Transfusion consideration
                                                            • اختلال در حجم مایعات بدن
                                                            • Fluid volume deficit (FVD)
                                                            • DEHYDRATION
                                                            • علل کاهش حجم خارج سلولی
                                                            • Signs of Hypovolemia
                                                            • Clinical Diagnosis of Hypovolemia
                                                            • Signs of Hypervolemia
                                                            • Management of Hypervolemia
                                                            • Fluid Management
                                                            • Electrolyte physiology
                                                            • Sodium physiology
                                                            • Osmotic Pressure
                                                            • Concentration
                                                            • Hypernatremia
                                                            • - Hypernatremia
                                                            • Slide 67
                                                            • Slide 68
                                                            • Clinical Manifestations of Abnormalities in Serum Sodium
                                                            • Treatment
                                                            • Water deficit (L)= times TBW
                                                            • The rate of fluid administration
                                                            • Hyponatremia Nalt135mEqL
                                                            • Slide 74
                                                            • Sodium depletion
                                                            • Sodium dilution
                                                            • Sign and symptoms
                                                            • Slide 78
                                                            • Treatment
                                                            • Slide 80
                                                            • Slide 81
                                                            • Dose
                                                            • Potassium abnormalities
                                                            • Hyperkalemia
                                                            • Clinical manifestation of hyperkalemia
                                                            • Slide 86
                                                            • Slide 87
                                                            • Hypokalemia
                                                            • Potassium changes associated with alkalosis
                                                            • Slide 90
                                                            • Clinical Manifestation of Abnormalities in potassium
                                                            • Slide 92
                                                            • Calcium
                                                            • هيپوكلسمي یونیزه Calt45 meql
                                                            • علائم هیپوکلسمی
                                                            • Slide 96
                                                            • Slide 97
                                                            • Slide 98
                                                            • Slide 99
                                                            • سایرعلائم
                                                            • درمان
                                                            • هيپركلسمي Cagt55meql
                                                            • علائم
                                                            • علائم قلبی
                                                            • Slide 105
                                                            • Magnesium Abnormalities
                                                            • منیزیوم
                                                            • Hypermagnesemia
                                                            • Clinical manifestation hypermanesemia
                                                            • Slide 110
                                                            • Slide 111
                                                            • Hypomagnesemia
                                                            • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                            • Slide 114
                                                            • Message for Today
                                                            • Slide 116

                                                              وریدی محلولهای

                                                              Fluids bull Crystalloids

                                                              bull Colloids

                                                              bull blood

                                                              Which of the following solutions is isotonic

                                                              A D5W

                                                              B 045 saline

                                                              C 09 saline

                                                              D D5 in 09 saline

                                                              SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                                                              ECFECF 142 4 5 103 27 280-310

                                                              Lactated Lactated RingerrsquosRingerrsquos

                                                              130 4 3 109 28 273

                                                              09 NaCl09 NaCl 154 154 308

                                                              045 045 NaClNaCl

                                                              77 77 154

                                                              D5WD5W

                                                              D5045 D5045 NaClNaCl

                                                              77 77 50 406

                                                              3 NaCl3 NaCl 513 513 1026

                                                              6 6 HetastarchHetastarch

                                                              500 154 154 310

                                                              5 5 AlbuminAlbumin

                                                              250500130-160

                                                              lt25130-160

                                                              330

                                                              25 25 AlbuminAlbumin

                                                              2050100130-160

                                                              lt25130-160

                                                              330

                                                              Common parenteral fluid therapyCommon parenteral fluid therapy

                                                              CrystalloidsCrystalloids

                                                              bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                                              Colloid SolutionsColloid Solutions

                                                              bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                                              - Haes-steril 10

                                                              الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                                              کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                                              ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                                              osm=273

                                                              09Nacl

                                                              bull Na=154

                                                              bull CL= 154

                                                              کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                                              PH=56است

                                                              Postoperative (maintenance)

                                                              045Nacl +5 dextrose +KCL

                                                              Perioperative management of fluid balance include

                                                              1 Preoperative evaluation

                                                              2 Intraoperative maintenance

                                                              3 Replacement of fluid losses

                                                              Preexisting fluid deficits

                                                              bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                                              bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                                              Maintenance requirements

                                                              bull Up to 10 kg = 4cckghr

                                                              bull 11-20kg = add 2cckghr

                                                              bull 21kg and above = add 1cckghr

                                                              bull Insensible losses = 2cckghr

                                                              Surgical fluid losses

                                                              Blood loss (measurement)

                                                              1 Suction container

                                                              2 Surgical sponge

                                                              3 Hct and tachycardia not specific

                                                              4 ABG and UO if hypoperfusion occur

                                                              5 Blood loss=31 with crystalloid

                                                              Other losses (third space loss)

                                                              Third space loss

                                                              1 Minimal (herniorrapy) =2-4cckghr

                                                              2 Moderate (cholecystectomy)=4-6cckghr

                                                              3 Severe (bowel resection) = 6-8cckghr

                                                              Crystalloid solution

                                                              1 The main solutions is either glucose or saline

                                                              2 Hypotonic or isotonic or hypertonic

                                                              3 Safe nontoxic reaction free inexpensive

                                                              4 Complication is edema if large volumes are needed

                                                              5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                              Colloids

                                                              1 Albumin

                                                              2 Hydroxyethyl starch

                                                              3 Dextran

                                                              Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                              factor )These colloid is best avoided in patients with

                                                              coagulopaty

                                                              The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                              1000cc

                                                              500cc

                                                              500cc

                                                              500cc

                                                              200

                                                              600

                                                              1000

                                                              Lactated Ringers

                                                              5 Albumin

                                                              6 Hetastarch

                                                              Whole blood

                                                              Blood volumeInfusion volume

                                                              Colloid versus crystalloid solutions

                                                              Transfusion consideration

                                                              bull HB lt7 mg dl increase CO

                                                              bull Ideal Hb is 7-8 mgdl

                                                              bull In IHD patients or pulmonary disease gt 10 mgdl

                                                              بدن مایعات حجم در اختالل

                                                              1 Fluid volume deficit

                                                              2 Fluid volume excess

                                                              Fluid volume deficit(FVD)

                                                              ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                              کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                              ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                              باشد آن با همراه دیگری اختالل مگر

                                                              DEHYDRATION

                                                              سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                              سلولی خارج حجم کاهش علل

                                                              1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                              2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                              کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                              Signs of HypovolemiaSigns of Hypovolemia

                                                              bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                              Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                              bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                              Signs of HypervolemiaSigns of Hypervolemia

                                                              bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                              Especially when hypo-albuminemia

                                                              Management of Management of HypervolemiaHypervolemia

                                                              bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                              Fluid ManagementFluid Management

                                                              bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                              Electrolyte physiology

                                                              Sodium physiology

                                                              Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                              Normal amount 135-145 meql

                                                              Osmotic Pressure

                                                              Calculated serum osmolality =

                                                              2 sodium+ glucose18 + BUN 28

                                                              Osmolality = 290 mosm

                                                              Concentration

                                                              1Serum sodium concentration2Serum osmolarity

                                                              bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                              drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                              DW5)

                                                              Hypernatremia

                                                              Serum Nagt145mEqL

                                                              - Hypernatremia

                                                              Loss of Free Water

                                                              Gain of sodium in excess of water

                                                              Hypernatremia

                                                              -Hypernatremia Hypo volemic

                                                              Hyper volemic

                                                              Normo volemic

                                                              Hypernatremia

                                                              Volume Status

                                                              Normal

                                                              Nonrenal water loss

                                                              Skin

                                                              Gastrointestinal

                                                              Renal water loss

                                                              Renal disease

                                                              Diuretics

                                                              Diabetes insipidus

                                                              High

                                                              Iatrogenic sodium administration

                                                              Mineralocorticoid excess

                                                              Aldosteronism

                                                              Cushingrsquos disease

                                                              Congenital adrenal

                                                              hyperplasia

                                                              Low

                                                              Nonrenal water loss

                                                              Skin

                                                              Gastrointestinal losses

                                                              Renal water losses

                                                              Renal (tubular) Diuretics

                                                              Osmotic diuretics

                                                              Diabetes insipidus

                                                              Adrenal failure

                                                              Asymptomatic

                                                              Hypernatremia Symptomatic (Nagt160 meqL)

                                                              Clinical Manifestations of Abnormalities in Serum Sodium

                                                              Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                              Body system hypernatremia

                                                              Treatment

                                                              Normal saline in hypovolemic patients

                                                              Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                              saline or entral water)

                                                              Water deficit (L)= times TBW

                                                              The formula used to estimate the amount of water required to correct hypernatremia

                                                              Estimate TBW as 55 of lean body mass in men and 45 in women

                                                              Serum sodium-140

                                                              140

                                                              The rate of fluid administration

                                                              1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                              2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                              Hyponatremia Nalt135mEqL

                                                              Causes

                                                              1 Sodium depletion

                                                              2 Sodium dilution

                                                              bull Incidence = 45

                                                              bull After surgery=1

                                                              bull Mortality = 2 times normal

                                                              Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                              volume deficit

                                                              Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                              Sign and symptoms

                                                              bull CNS symptom when Nalt123 meql

                                                              bull Cardiac symptom when Nalt100 meql

                                                              For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                              Body System Hyponatremia

                                                              central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                              reflexes seizures coma increased intracranial pressure

                                                              Musculoskeletal Weakness fatigue muscle crampstwitching

                                                              Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                              Cardiovascular Hypertension and bradycardia if significant increases in

                                                              intracranial pressure

                                                              Tissue Lacrimation salivation

                                                              Renal Oliguria

                                                              Clinical Manifestations of Abnormalities in Serum Sodium

                                                              Treatment

                                                              1=Depend on ECF

                                                              2=CNS sign

                                                              Treatment

                                                              1 Asymptomatic increase the sodium level by no more than

                                                              05-1 meqLh to a maximum increase of 12 meqL per day

                                                              2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                              more than 1meqL per hour until the serum Na level reaches 130

                                                              meqL or neurologic symptoms are improved

                                                              Rapid correction of hyponatremia

                                                              Pontine myelinolysis

                                                              Seizures weaknessparesis akinetic

                                                              movements unresponsiveness

                                                              Permanent brain damage

                                                              Death

                                                              Dose

                                                              Na deficit meq =(140- Na meql) TBW

                                                              باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                              شود اصالح آهسته سپس

                                                              Potassium abnormalities

                                                              bull The average dietary intake of potassium 50-100meqd

                                                              bull The average renal excretion of potassium 10-700 meqd

                                                              - 2 of the total body potassium in ECF (45meqL)

                                                              - Factors that influence serum potassium

                                                              1 Surgical stress

                                                              2 Injury

                                                              3 Acidosis

                                                              4 Tissue catabolism

                                                              Hyperkalemia

                                                              The normal range of serum potassium 35-5 meqL

                                                              Etiology of Hyperkalemia

                                                              Increased intake Potassium supplementation

                                                              Blood transfusions

                                                              Endogenous loaddestruction

                                                              hemolysis rhabdomyolysis

                                                              cruch injury gastrointestinal hemorrhage

                                                              Increased release Acidosis

                                                              Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                              Renal insufficiencyfailure

                                                              Clinical manifestation of hyperkalemia

                                                              System hyperkalemia

                                                              Gastrointestinal Nauseavomiting colic diarrhea

                                                              Neuromuscular weakness paralysis respiratory failure

                                                              Cardiovascular Arrhythmia arrest

                                                              ECG changes Peaked T waves (early change)

                                                              Flattened P wave

                                                              Prolonged PR interval (first-degree block)

                                                              Widened QRS complex

                                                              Sine wave formation

                                                              Ventricular fibrillation

                                                              Treatment

                                                              Treatment of symptomatic hyperkalemia

                                                              Potassium removal Kayexalate

                                                              Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                              Rectal administration is 50 g in 200 mL 20 sorbitol

                                                              Dialysis

                                                              Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                              Bicarbonate 1 vial intravenous

                                                              Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                              HypokalemiaEtiology

                                                              inadequate intake

                                                              Dietary potassium-free intravenous fluids potassium-deficient

                                                              total parenteral nutrition

                                                              Excessive potassium excretion

                                                              Hyperaldosteronism

                                                              Medications

                                                              Gastrointestinal losses

                                                              Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                              Renal loss of potassium (gastric fluid either as vomiting or high

                                                              nasogastric output)

                                                              Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                              Potassium changes associated with alkalosis

                                                              Potassium decrease by 03 meqL for every 01

                                                              increase in PH above normal

                                                              Magnesium Depletion

                                                              (drug induced amphotericin amioglycosides cisplatin)

                                                              Renal potassium wastage

                                                              Hypokalemia

                                                              Magnesium Depletion

                                                              (drug induced amphotericin amioglycosides cisplatin)

                                                              Renal potassium wastage

                                                              Hypokalemia

                                                              Clinical Manifestation of Abnormalities in potassium

                                                              System hypokalemia

                                                              Gastrointestinal Ileus constipation

                                                              Neuromuscular Decreased reflexes fatigue weakness

                                                              paralysis

                                                              Cardiovascular Arrest

                                                              ECG changes U-waves

                                                              T-wave flattening

                                                              ST-segment changes

                                                              Arrhythmias

                                                              Treatment

                                                              Potassium

                                                              Serum potassium level lt40 mEqL

                                                              Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                              times 1 doses

                                                              Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                              Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                              Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                              asymptomatic replace as per above protocol

                                                              Electrolyte Replacement Therapy Protocol

                                                              bull Oral repletion for mild and asymptomatic hypokalemia

                                                              bull IV repletion for severe and symptomatic hypokalemia

                                                              Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                              ( دندانها( ndash استخوانbull كلسيم نقش

                                                              عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                              صاف 2 عضالت انقباض

                                                              هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                              انعقاد 4

                                                              یونیزه Calt45 meql هيپوكلسمي

                                                              عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                              ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                              میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                              ( شود می پیوند شده

                                                              هیپوکلسمی عالئم

                                                              رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                              سایرعالئم

                                                              قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                              درمان

                                                              ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                              Cagt55meql هيپركلسمي

                                                              هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                              عالئم

                                                              bullGI

                                                              bullCardiovascular bullRenal (polyuria)

                                                              bullCNS

                                                              قلبی عالئم

                                                              bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                              QRS شدن )Q-Tوكوتاه

                                                              درمان

                                                              ایزوتونیک 1 نمکی محلول انفوزیون

                                                              الزیکس2

                                                              تونین 3 کلسی

                                                              کورتون4

                                                              دیالیز5

                                                              Magnesium Abnormalities

                                                              Normal dietary intake 20meq (240mg)

                                                              Excretion in both the feces and urine

                                                              Normal serum level 19-25 mgdL

                                                              منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                              تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                              bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                              Hypermagnesemia

                                                              Etiology

                                                              1 Impaired renal function

                                                              2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                              Clinical manifestation hypermanesemia

                                                              System hypermanesemia

                                                              Gastrointestinal Nauseavomiting

                                                              Neuromuscular weakness lethargy Decreased

                                                              reflexes

                                                              Cardiovascular Hypotension arrest

                                                              ECG changes Increased PR interval

                                                              Widened QRS complex

                                                              Elevated T waves

                                                              Treatment

                                                              1 Withhold exogenous sources of magnesium

                                                              2 Correct volume deficit

                                                              3 Correct acidosis if present

                                                              4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                              5 Dialysis (if elevated levels or symptoms persist)

                                                              عالئم

                                                              bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                              meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                              meqL

                                                              Hypomagnesemia

                                                              Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                              homeostasis

                                                              Etiology

                                                              1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                              inadequate supplementation of magnesium)

                                                              2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                              3 GI losses (diarrhea)

                                                              4 Malabsorption

                                                              5 Acute pancreatitis

                                                              6 Diabetic ketoacidosis

                                                              7 Primary aldosteronism

                                                              Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                              1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                              2 Delirium and seizures in severe deficiency

                                                              3 ECG changes Prolonged QT and PR interval

                                                              ST-segment depression

                                                              Flattening or inversion of P waves

                                                              Torsades de pointes

                                                              Arrhythmia

                                                              Treatment

                                                              1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                              2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                              Message for Today

                                                              ICF

                                                              Interstitial

                                                              Pla

                                                              sma

                                                              5 Dex

                                                              bull Do not reccussitate sick patients with any Dextrose solution

                                                              • Fluid and Electrolyte Management of the Surgical Patient
                                                              • Slide 2
                                                              • Slide 3
                                                              • Slide 4
                                                              • Total Body Water
                                                              • Body Fluid Compartments
                                                              • Total body water (TBW)
                                                              • Body compartment fluid
                                                              • Example men with 70kg
                                                              • Fluid compartments
                                                              • Slide 11
                                                              • Slide 12
                                                              • Slide 13
                                                              • Slide 14
                                                              • Slide 15
                                                              • Colloid osmotic pressure
                                                              • Slide 17
                                                              • Slide 18
                                                              • Slide 19
                                                              • Cell Membrane
                                                              • Slide 21
                                                              • Slide 22
                                                              • Slide 23
                                                              • Slide 24
                                                              • Slide 25
                                                              • Composition of Fluid Compartments
                                                              • Composition of Body Fluids
                                                              • عوامل موثر روی تغییرات آب والکترولیت
                                                              • Reasons for fluid therapy
                                                              • ارزیابی حجم مایع داخل عروقی
                                                              • محلولهای وریدی
                                                              • Fluids
                                                              • Slide 33
                                                              • Slide 34
                                                              • Slide 35
                                                              • Crystalloids
                                                              • Colloid Solutions
                                                              • رینگر لاکتات
                                                              • 09Nacl
                                                              • Postoperative (maintenance)
                                                              • Slide 41
                                                              • Preexisting fluid deficits
                                                              • Maintenance requirements
                                                              • Surgical fluid losses
                                                              • Third space loss
                                                              • Crystalloid solution
                                                              • Colloids
                                                              • Complications
                                                              • The Influence of Colloid amp Crystalloid on Blood Volume
                                                              • Colloid versus crystalloid solutions
                                                              • Transfusion consideration
                                                              • اختلال در حجم مایعات بدن
                                                              • Fluid volume deficit (FVD)
                                                              • DEHYDRATION
                                                              • علل کاهش حجم خارج سلولی
                                                              • Signs of Hypovolemia
                                                              • Clinical Diagnosis of Hypovolemia
                                                              • Signs of Hypervolemia
                                                              • Management of Hypervolemia
                                                              • Fluid Management
                                                              • Electrolyte physiology
                                                              • Sodium physiology
                                                              • Osmotic Pressure
                                                              • Concentration
                                                              • Hypernatremia
                                                              • - Hypernatremia
                                                              • Slide 67
                                                              • Slide 68
                                                              • Clinical Manifestations of Abnormalities in Serum Sodium
                                                              • Treatment
                                                              • Water deficit (L)= times TBW
                                                              • The rate of fluid administration
                                                              • Hyponatremia Nalt135mEqL
                                                              • Slide 74
                                                              • Sodium depletion
                                                              • Sodium dilution
                                                              • Sign and symptoms
                                                              • Slide 78
                                                              • Treatment
                                                              • Slide 80
                                                              • Slide 81
                                                              • Dose
                                                              • Potassium abnormalities
                                                              • Hyperkalemia
                                                              • Clinical manifestation of hyperkalemia
                                                              • Slide 86
                                                              • Slide 87
                                                              • Hypokalemia
                                                              • Potassium changes associated with alkalosis
                                                              • Slide 90
                                                              • Clinical Manifestation of Abnormalities in potassium
                                                              • Slide 92
                                                              • Calcium
                                                              • هيپوكلسمي یونیزه Calt45 meql
                                                              • علائم هیپوکلسمی
                                                              • Slide 96
                                                              • Slide 97
                                                              • Slide 98
                                                              • Slide 99
                                                              • سایرعلائم
                                                              • درمان
                                                              • هيپركلسمي Cagt55meql
                                                              • علائم
                                                              • علائم قلبی
                                                              • Slide 105
                                                              • Magnesium Abnormalities
                                                              • منیزیوم
                                                              • Hypermagnesemia
                                                              • Clinical manifestation hypermanesemia
                                                              • Slide 110
                                                              • Slide 111
                                                              • Hypomagnesemia
                                                              • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                              • Slide 114
                                                              • Message for Today
                                                              • Slide 116

                                                                Fluids bull Crystalloids

                                                                bull Colloids

                                                                bull blood

                                                                Which of the following solutions is isotonic

                                                                A D5W

                                                                B 045 saline

                                                                C 09 saline

                                                                D D5 in 09 saline

                                                                SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                                                                ECFECF 142 4 5 103 27 280-310

                                                                Lactated Lactated RingerrsquosRingerrsquos

                                                                130 4 3 109 28 273

                                                                09 NaCl09 NaCl 154 154 308

                                                                045 045 NaClNaCl

                                                                77 77 154

                                                                D5WD5W

                                                                D5045 D5045 NaClNaCl

                                                                77 77 50 406

                                                                3 NaCl3 NaCl 513 513 1026

                                                                6 6 HetastarchHetastarch

                                                                500 154 154 310

                                                                5 5 AlbuminAlbumin

                                                                250500130-160

                                                                lt25130-160

                                                                330

                                                                25 25 AlbuminAlbumin

                                                                2050100130-160

                                                                lt25130-160

                                                                330

                                                                Common parenteral fluid therapyCommon parenteral fluid therapy

                                                                CrystalloidsCrystalloids

                                                                bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                                                Colloid SolutionsColloid Solutions

                                                                bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                                                - Haes-steril 10

                                                                الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                                                کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                                                ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                                                osm=273

                                                                09Nacl

                                                                bull Na=154

                                                                bull CL= 154

                                                                کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                                                PH=56است

                                                                Postoperative (maintenance)

                                                                045Nacl +5 dextrose +KCL

                                                                Perioperative management of fluid balance include

                                                                1 Preoperative evaluation

                                                                2 Intraoperative maintenance

                                                                3 Replacement of fluid losses

                                                                Preexisting fluid deficits

                                                                bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                                                bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                                                Maintenance requirements

                                                                bull Up to 10 kg = 4cckghr

                                                                bull 11-20kg = add 2cckghr

                                                                bull 21kg and above = add 1cckghr

                                                                bull Insensible losses = 2cckghr

                                                                Surgical fluid losses

                                                                Blood loss (measurement)

                                                                1 Suction container

                                                                2 Surgical sponge

                                                                3 Hct and tachycardia not specific

                                                                4 ABG and UO if hypoperfusion occur

                                                                5 Blood loss=31 with crystalloid

                                                                Other losses (third space loss)

                                                                Third space loss

                                                                1 Minimal (herniorrapy) =2-4cckghr

                                                                2 Moderate (cholecystectomy)=4-6cckghr

                                                                3 Severe (bowel resection) = 6-8cckghr

                                                                Crystalloid solution

                                                                1 The main solutions is either glucose or saline

                                                                2 Hypotonic or isotonic or hypertonic

                                                                3 Safe nontoxic reaction free inexpensive

                                                                4 Complication is edema if large volumes are needed

                                                                5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                                Colloids

                                                                1 Albumin

                                                                2 Hydroxyethyl starch

                                                                3 Dextran

                                                                Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                                factor )These colloid is best avoided in patients with

                                                                coagulopaty

                                                                The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                                1000cc

                                                                500cc

                                                                500cc

                                                                500cc

                                                                200

                                                                600

                                                                1000

                                                                Lactated Ringers

                                                                5 Albumin

                                                                6 Hetastarch

                                                                Whole blood

                                                                Blood volumeInfusion volume

                                                                Colloid versus crystalloid solutions

                                                                Transfusion consideration

                                                                bull HB lt7 mg dl increase CO

                                                                bull Ideal Hb is 7-8 mgdl

                                                                bull In IHD patients or pulmonary disease gt 10 mgdl

                                                                بدن مایعات حجم در اختالل

                                                                1 Fluid volume deficit

                                                                2 Fluid volume excess

                                                                Fluid volume deficit(FVD)

                                                                ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                باشد آن با همراه دیگری اختالل مگر

                                                                DEHYDRATION

                                                                سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                سلولی خارج حجم کاهش علل

                                                                1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                Signs of HypovolemiaSigns of Hypovolemia

                                                                bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                Signs of HypervolemiaSigns of Hypervolemia

                                                                bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                Especially when hypo-albuminemia

                                                                Management of Management of HypervolemiaHypervolemia

                                                                bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                Fluid ManagementFluid Management

                                                                bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                Electrolyte physiology

                                                                Sodium physiology

                                                                Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                Normal amount 135-145 meql

                                                                Osmotic Pressure

                                                                Calculated serum osmolality =

                                                                2 sodium+ glucose18 + BUN 28

                                                                Osmolality = 290 mosm

                                                                Concentration

                                                                1Serum sodium concentration2Serum osmolarity

                                                                bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                DW5)

                                                                Hypernatremia

                                                                Serum Nagt145mEqL

                                                                - Hypernatremia

                                                                Loss of Free Water

                                                                Gain of sodium in excess of water

                                                                Hypernatremia

                                                                -Hypernatremia Hypo volemic

                                                                Hyper volemic

                                                                Normo volemic

                                                                Hypernatremia

                                                                Volume Status

                                                                Normal

                                                                Nonrenal water loss

                                                                Skin

                                                                Gastrointestinal

                                                                Renal water loss

                                                                Renal disease

                                                                Diuretics

                                                                Diabetes insipidus

                                                                High

                                                                Iatrogenic sodium administration

                                                                Mineralocorticoid excess

                                                                Aldosteronism

                                                                Cushingrsquos disease

                                                                Congenital adrenal

                                                                hyperplasia

                                                                Low

                                                                Nonrenal water loss

                                                                Skin

                                                                Gastrointestinal losses

                                                                Renal water losses

                                                                Renal (tubular) Diuretics

                                                                Osmotic diuretics

                                                                Diabetes insipidus

                                                                Adrenal failure

                                                                Asymptomatic

                                                                Hypernatremia Symptomatic (Nagt160 meqL)

                                                                Clinical Manifestations of Abnormalities in Serum Sodium

                                                                Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                Body system hypernatremia

                                                                Treatment

                                                                Normal saline in hypovolemic patients

                                                                Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                saline or entral water)

                                                                Water deficit (L)= times TBW

                                                                The formula used to estimate the amount of water required to correct hypernatremia

                                                                Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                Serum sodium-140

                                                                140

                                                                The rate of fluid administration

                                                                1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                Hyponatremia Nalt135mEqL

                                                                Causes

                                                                1 Sodium depletion

                                                                2 Sodium dilution

                                                                bull Incidence = 45

                                                                bull After surgery=1

                                                                bull Mortality = 2 times normal

                                                                Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                volume deficit

                                                                Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                Sign and symptoms

                                                                bull CNS symptom when Nalt123 meql

                                                                bull Cardiac symptom when Nalt100 meql

                                                                For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                Body System Hyponatremia

                                                                central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                reflexes seizures coma increased intracranial pressure

                                                                Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                Cardiovascular Hypertension and bradycardia if significant increases in

                                                                intracranial pressure

                                                                Tissue Lacrimation salivation

                                                                Renal Oliguria

                                                                Clinical Manifestations of Abnormalities in Serum Sodium

                                                                Treatment

                                                                1=Depend on ECF

                                                                2=CNS sign

                                                                Treatment

                                                                1 Asymptomatic increase the sodium level by no more than

                                                                05-1 meqLh to a maximum increase of 12 meqL per day

                                                                2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                more than 1meqL per hour until the serum Na level reaches 130

                                                                meqL or neurologic symptoms are improved

                                                                Rapid correction of hyponatremia

                                                                Pontine myelinolysis

                                                                Seizures weaknessparesis akinetic

                                                                movements unresponsiveness

                                                                Permanent brain damage

                                                                Death

                                                                Dose

                                                                Na deficit meq =(140- Na meql) TBW

                                                                باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                شود اصالح آهسته سپس

                                                                Potassium abnormalities

                                                                bull The average dietary intake of potassium 50-100meqd

                                                                bull The average renal excretion of potassium 10-700 meqd

                                                                - 2 of the total body potassium in ECF (45meqL)

                                                                - Factors that influence serum potassium

                                                                1 Surgical stress

                                                                2 Injury

                                                                3 Acidosis

                                                                4 Tissue catabolism

                                                                Hyperkalemia

                                                                The normal range of serum potassium 35-5 meqL

                                                                Etiology of Hyperkalemia

                                                                Increased intake Potassium supplementation

                                                                Blood transfusions

                                                                Endogenous loaddestruction

                                                                hemolysis rhabdomyolysis

                                                                cruch injury gastrointestinal hemorrhage

                                                                Increased release Acidosis

                                                                Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                Renal insufficiencyfailure

                                                                Clinical manifestation of hyperkalemia

                                                                System hyperkalemia

                                                                Gastrointestinal Nauseavomiting colic diarrhea

                                                                Neuromuscular weakness paralysis respiratory failure

                                                                Cardiovascular Arrhythmia arrest

                                                                ECG changes Peaked T waves (early change)

                                                                Flattened P wave

                                                                Prolonged PR interval (first-degree block)

                                                                Widened QRS complex

                                                                Sine wave formation

                                                                Ventricular fibrillation

                                                                Treatment

                                                                Treatment of symptomatic hyperkalemia

                                                                Potassium removal Kayexalate

                                                                Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                Dialysis

                                                                Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                Bicarbonate 1 vial intravenous

                                                                Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                HypokalemiaEtiology

                                                                inadequate intake

                                                                Dietary potassium-free intravenous fluids potassium-deficient

                                                                total parenteral nutrition

                                                                Excessive potassium excretion

                                                                Hyperaldosteronism

                                                                Medications

                                                                Gastrointestinal losses

                                                                Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                Renal loss of potassium (gastric fluid either as vomiting or high

                                                                nasogastric output)

                                                                Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                Potassium changes associated with alkalosis

                                                                Potassium decrease by 03 meqL for every 01

                                                                increase in PH above normal

                                                                Magnesium Depletion

                                                                (drug induced amphotericin amioglycosides cisplatin)

                                                                Renal potassium wastage

                                                                Hypokalemia

                                                                Magnesium Depletion

                                                                (drug induced amphotericin amioglycosides cisplatin)

                                                                Renal potassium wastage

                                                                Hypokalemia

                                                                Clinical Manifestation of Abnormalities in potassium

                                                                System hypokalemia

                                                                Gastrointestinal Ileus constipation

                                                                Neuromuscular Decreased reflexes fatigue weakness

                                                                paralysis

                                                                Cardiovascular Arrest

                                                                ECG changes U-waves

                                                                T-wave flattening

                                                                ST-segment changes

                                                                Arrhythmias

                                                                Treatment

                                                                Potassium

                                                                Serum potassium level lt40 mEqL

                                                                Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                times 1 doses

                                                                Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                asymptomatic replace as per above protocol

                                                                Electrolyte Replacement Therapy Protocol

                                                                bull Oral repletion for mild and asymptomatic hypokalemia

                                                                bull IV repletion for severe and symptomatic hypokalemia

                                                                Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                ( دندانها( ndash استخوانbull كلسيم نقش

                                                                عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                صاف 2 عضالت انقباض

                                                                هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                انعقاد 4

                                                                یونیزه Calt45 meql هيپوكلسمي

                                                                عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                ( شود می پیوند شده

                                                                هیپوکلسمی عالئم

                                                                رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                سایرعالئم

                                                                قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                درمان

                                                                ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                Cagt55meql هيپركلسمي

                                                                هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                عالئم

                                                                bullGI

                                                                bullCardiovascular bullRenal (polyuria)

                                                                bullCNS

                                                                قلبی عالئم

                                                                bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                QRS شدن )Q-Tوكوتاه

                                                                درمان

                                                                ایزوتونیک 1 نمکی محلول انفوزیون

                                                                الزیکس2

                                                                تونین 3 کلسی

                                                                کورتون4

                                                                دیالیز5

                                                                Magnesium Abnormalities

                                                                Normal dietary intake 20meq (240mg)

                                                                Excretion in both the feces and urine

                                                                Normal serum level 19-25 mgdL

                                                                منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                Hypermagnesemia

                                                                Etiology

                                                                1 Impaired renal function

                                                                2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                Clinical manifestation hypermanesemia

                                                                System hypermanesemia

                                                                Gastrointestinal Nauseavomiting

                                                                Neuromuscular weakness lethargy Decreased

                                                                reflexes

                                                                Cardiovascular Hypotension arrest

                                                                ECG changes Increased PR interval

                                                                Widened QRS complex

                                                                Elevated T waves

                                                                Treatment

                                                                1 Withhold exogenous sources of magnesium

                                                                2 Correct volume deficit

                                                                3 Correct acidosis if present

                                                                4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                5 Dialysis (if elevated levels or symptoms persist)

                                                                عالئم

                                                                bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                meqL

                                                                Hypomagnesemia

                                                                Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                homeostasis

                                                                Etiology

                                                                1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                inadequate supplementation of magnesium)

                                                                2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                3 GI losses (diarrhea)

                                                                4 Malabsorption

                                                                5 Acute pancreatitis

                                                                6 Diabetic ketoacidosis

                                                                7 Primary aldosteronism

                                                                Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                2 Delirium and seizures in severe deficiency

                                                                3 ECG changes Prolonged QT and PR interval

                                                                ST-segment depression

                                                                Flattening or inversion of P waves

                                                                Torsades de pointes

                                                                Arrhythmia

                                                                Treatment

                                                                1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                Message for Today

                                                                ICF

                                                                Interstitial

                                                                Pla

                                                                sma

                                                                5 Dex

                                                                bull Do not reccussitate sick patients with any Dextrose solution

                                                                • Fluid and Electrolyte Management of the Surgical Patient
                                                                • Slide 2
                                                                • Slide 3
                                                                • Slide 4
                                                                • Total Body Water
                                                                • Body Fluid Compartments
                                                                • Total body water (TBW)
                                                                • Body compartment fluid
                                                                • Example men with 70kg
                                                                • Fluid compartments
                                                                • Slide 11
                                                                • Slide 12
                                                                • Slide 13
                                                                • Slide 14
                                                                • Slide 15
                                                                • Colloid osmotic pressure
                                                                • Slide 17
                                                                • Slide 18
                                                                • Slide 19
                                                                • Cell Membrane
                                                                • Slide 21
                                                                • Slide 22
                                                                • Slide 23
                                                                • Slide 24
                                                                • Slide 25
                                                                • Composition of Fluid Compartments
                                                                • Composition of Body Fluids
                                                                • عوامل موثر روی تغییرات آب والکترولیت
                                                                • Reasons for fluid therapy
                                                                • ارزیابی حجم مایع داخل عروقی
                                                                • محلولهای وریدی
                                                                • Fluids
                                                                • Slide 33
                                                                • Slide 34
                                                                • Slide 35
                                                                • Crystalloids
                                                                • Colloid Solutions
                                                                • رینگر لاکتات
                                                                • 09Nacl
                                                                • Postoperative (maintenance)
                                                                • Slide 41
                                                                • Preexisting fluid deficits
                                                                • Maintenance requirements
                                                                • Surgical fluid losses
                                                                • Third space loss
                                                                • Crystalloid solution
                                                                • Colloids
                                                                • Complications
                                                                • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                • Colloid versus crystalloid solutions
                                                                • Transfusion consideration
                                                                • اختلال در حجم مایعات بدن
                                                                • Fluid volume deficit (FVD)
                                                                • DEHYDRATION
                                                                • علل کاهش حجم خارج سلولی
                                                                • Signs of Hypovolemia
                                                                • Clinical Diagnosis of Hypovolemia
                                                                • Signs of Hypervolemia
                                                                • Management of Hypervolemia
                                                                • Fluid Management
                                                                • Electrolyte physiology
                                                                • Sodium physiology
                                                                • Osmotic Pressure
                                                                • Concentration
                                                                • Hypernatremia
                                                                • - Hypernatremia
                                                                • Slide 67
                                                                • Slide 68
                                                                • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                • Treatment
                                                                • Water deficit (L)= times TBW
                                                                • The rate of fluid administration
                                                                • Hyponatremia Nalt135mEqL
                                                                • Slide 74
                                                                • Sodium depletion
                                                                • Sodium dilution
                                                                • Sign and symptoms
                                                                • Slide 78
                                                                • Treatment
                                                                • Slide 80
                                                                • Slide 81
                                                                • Dose
                                                                • Potassium abnormalities
                                                                • Hyperkalemia
                                                                • Clinical manifestation of hyperkalemia
                                                                • Slide 86
                                                                • Slide 87
                                                                • Hypokalemia
                                                                • Potassium changes associated with alkalosis
                                                                • Slide 90
                                                                • Clinical Manifestation of Abnormalities in potassium
                                                                • Slide 92
                                                                • Calcium
                                                                • هيپوكلسمي یونیزه Calt45 meql
                                                                • علائم هیپوکلسمی
                                                                • Slide 96
                                                                • Slide 97
                                                                • Slide 98
                                                                • Slide 99
                                                                • سایرعلائم
                                                                • درمان
                                                                • هيپركلسمي Cagt55meql
                                                                • علائم
                                                                • علائم قلبی
                                                                • Slide 105
                                                                • Magnesium Abnormalities
                                                                • منیزیوم
                                                                • Hypermagnesemia
                                                                • Clinical manifestation hypermanesemia
                                                                • Slide 110
                                                                • Slide 111
                                                                • Hypomagnesemia
                                                                • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                • Slide 114
                                                                • Message for Today
                                                                • Slide 116

                                                                  Which of the following solutions is isotonic

                                                                  A D5W

                                                                  B 045 saline

                                                                  C 09 saline

                                                                  D D5 in 09 saline

                                                                  SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                                                                  ECFECF 142 4 5 103 27 280-310

                                                                  Lactated Lactated RingerrsquosRingerrsquos

                                                                  130 4 3 109 28 273

                                                                  09 NaCl09 NaCl 154 154 308

                                                                  045 045 NaClNaCl

                                                                  77 77 154

                                                                  D5WD5W

                                                                  D5045 D5045 NaClNaCl

                                                                  77 77 50 406

                                                                  3 NaCl3 NaCl 513 513 1026

                                                                  6 6 HetastarchHetastarch

                                                                  500 154 154 310

                                                                  5 5 AlbuminAlbumin

                                                                  250500130-160

                                                                  lt25130-160

                                                                  330

                                                                  25 25 AlbuminAlbumin

                                                                  2050100130-160

                                                                  lt25130-160

                                                                  330

                                                                  Common parenteral fluid therapyCommon parenteral fluid therapy

                                                                  CrystalloidsCrystalloids

                                                                  bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                                                  Colloid SolutionsColloid Solutions

                                                                  bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                                                  - Haes-steril 10

                                                                  الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                                                  کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                                                  ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                                                  osm=273

                                                                  09Nacl

                                                                  bull Na=154

                                                                  bull CL= 154

                                                                  کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                                                  PH=56است

                                                                  Postoperative (maintenance)

                                                                  045Nacl +5 dextrose +KCL

                                                                  Perioperative management of fluid balance include

                                                                  1 Preoperative evaluation

                                                                  2 Intraoperative maintenance

                                                                  3 Replacement of fluid losses

                                                                  Preexisting fluid deficits

                                                                  bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                                                  bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                                                  Maintenance requirements

                                                                  bull Up to 10 kg = 4cckghr

                                                                  bull 11-20kg = add 2cckghr

                                                                  bull 21kg and above = add 1cckghr

                                                                  bull Insensible losses = 2cckghr

                                                                  Surgical fluid losses

                                                                  Blood loss (measurement)

                                                                  1 Suction container

                                                                  2 Surgical sponge

                                                                  3 Hct and tachycardia not specific

                                                                  4 ABG and UO if hypoperfusion occur

                                                                  5 Blood loss=31 with crystalloid

                                                                  Other losses (third space loss)

                                                                  Third space loss

                                                                  1 Minimal (herniorrapy) =2-4cckghr

                                                                  2 Moderate (cholecystectomy)=4-6cckghr

                                                                  3 Severe (bowel resection) = 6-8cckghr

                                                                  Crystalloid solution

                                                                  1 The main solutions is either glucose or saline

                                                                  2 Hypotonic or isotonic or hypertonic

                                                                  3 Safe nontoxic reaction free inexpensive

                                                                  4 Complication is edema if large volumes are needed

                                                                  5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                                  Colloids

                                                                  1 Albumin

                                                                  2 Hydroxyethyl starch

                                                                  3 Dextran

                                                                  Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                                  factor )These colloid is best avoided in patients with

                                                                  coagulopaty

                                                                  The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                                  1000cc

                                                                  500cc

                                                                  500cc

                                                                  500cc

                                                                  200

                                                                  600

                                                                  1000

                                                                  Lactated Ringers

                                                                  5 Albumin

                                                                  6 Hetastarch

                                                                  Whole blood

                                                                  Blood volumeInfusion volume

                                                                  Colloid versus crystalloid solutions

                                                                  Transfusion consideration

                                                                  bull HB lt7 mg dl increase CO

                                                                  bull Ideal Hb is 7-8 mgdl

                                                                  bull In IHD patients or pulmonary disease gt 10 mgdl

                                                                  بدن مایعات حجم در اختالل

                                                                  1 Fluid volume deficit

                                                                  2 Fluid volume excess

                                                                  Fluid volume deficit(FVD)

                                                                  ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                  کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                  ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                  باشد آن با همراه دیگری اختالل مگر

                                                                  DEHYDRATION

                                                                  سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                  سلولی خارج حجم کاهش علل

                                                                  1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                  2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                  کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                  Signs of HypovolemiaSigns of Hypovolemia

                                                                  bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                  Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                  bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                  Signs of HypervolemiaSigns of Hypervolemia

                                                                  bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                  Especially when hypo-albuminemia

                                                                  Management of Management of HypervolemiaHypervolemia

                                                                  bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                  Fluid ManagementFluid Management

                                                                  bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                  Electrolyte physiology

                                                                  Sodium physiology

                                                                  Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                  Normal amount 135-145 meql

                                                                  Osmotic Pressure

                                                                  Calculated serum osmolality =

                                                                  2 sodium+ glucose18 + BUN 28

                                                                  Osmolality = 290 mosm

                                                                  Concentration

                                                                  1Serum sodium concentration2Serum osmolarity

                                                                  bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                  drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                  DW5)

                                                                  Hypernatremia

                                                                  Serum Nagt145mEqL

                                                                  - Hypernatremia

                                                                  Loss of Free Water

                                                                  Gain of sodium in excess of water

                                                                  Hypernatremia

                                                                  -Hypernatremia Hypo volemic

                                                                  Hyper volemic

                                                                  Normo volemic

                                                                  Hypernatremia

                                                                  Volume Status

                                                                  Normal

                                                                  Nonrenal water loss

                                                                  Skin

                                                                  Gastrointestinal

                                                                  Renal water loss

                                                                  Renal disease

                                                                  Diuretics

                                                                  Diabetes insipidus

                                                                  High

                                                                  Iatrogenic sodium administration

                                                                  Mineralocorticoid excess

                                                                  Aldosteronism

                                                                  Cushingrsquos disease

                                                                  Congenital adrenal

                                                                  hyperplasia

                                                                  Low

                                                                  Nonrenal water loss

                                                                  Skin

                                                                  Gastrointestinal losses

                                                                  Renal water losses

                                                                  Renal (tubular) Diuretics

                                                                  Osmotic diuretics

                                                                  Diabetes insipidus

                                                                  Adrenal failure

                                                                  Asymptomatic

                                                                  Hypernatremia Symptomatic (Nagt160 meqL)

                                                                  Clinical Manifestations of Abnormalities in Serum Sodium

                                                                  Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                  Body system hypernatremia

                                                                  Treatment

                                                                  Normal saline in hypovolemic patients

                                                                  Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                  saline or entral water)

                                                                  Water deficit (L)= times TBW

                                                                  The formula used to estimate the amount of water required to correct hypernatremia

                                                                  Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                  Serum sodium-140

                                                                  140

                                                                  The rate of fluid administration

                                                                  1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                  2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                  Hyponatremia Nalt135mEqL

                                                                  Causes

                                                                  1 Sodium depletion

                                                                  2 Sodium dilution

                                                                  bull Incidence = 45

                                                                  bull After surgery=1

                                                                  bull Mortality = 2 times normal

                                                                  Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                  volume deficit

                                                                  Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                  Sign and symptoms

                                                                  bull CNS symptom when Nalt123 meql

                                                                  bull Cardiac symptom when Nalt100 meql

                                                                  For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                  Body System Hyponatremia

                                                                  central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                  reflexes seizures coma increased intracranial pressure

                                                                  Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                  Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                  Cardiovascular Hypertension and bradycardia if significant increases in

                                                                  intracranial pressure

                                                                  Tissue Lacrimation salivation

                                                                  Renal Oliguria

                                                                  Clinical Manifestations of Abnormalities in Serum Sodium

                                                                  Treatment

                                                                  1=Depend on ECF

                                                                  2=CNS sign

                                                                  Treatment

                                                                  1 Asymptomatic increase the sodium level by no more than

                                                                  05-1 meqLh to a maximum increase of 12 meqL per day

                                                                  2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                  more than 1meqL per hour until the serum Na level reaches 130

                                                                  meqL or neurologic symptoms are improved

                                                                  Rapid correction of hyponatremia

                                                                  Pontine myelinolysis

                                                                  Seizures weaknessparesis akinetic

                                                                  movements unresponsiveness

                                                                  Permanent brain damage

                                                                  Death

                                                                  Dose

                                                                  Na deficit meq =(140- Na meql) TBW

                                                                  باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                  شود اصالح آهسته سپس

                                                                  Potassium abnormalities

                                                                  bull The average dietary intake of potassium 50-100meqd

                                                                  bull The average renal excretion of potassium 10-700 meqd

                                                                  - 2 of the total body potassium in ECF (45meqL)

                                                                  - Factors that influence serum potassium

                                                                  1 Surgical stress

                                                                  2 Injury

                                                                  3 Acidosis

                                                                  4 Tissue catabolism

                                                                  Hyperkalemia

                                                                  The normal range of serum potassium 35-5 meqL

                                                                  Etiology of Hyperkalemia

                                                                  Increased intake Potassium supplementation

                                                                  Blood transfusions

                                                                  Endogenous loaddestruction

                                                                  hemolysis rhabdomyolysis

                                                                  cruch injury gastrointestinal hemorrhage

                                                                  Increased release Acidosis

                                                                  Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                  Renal insufficiencyfailure

                                                                  Clinical manifestation of hyperkalemia

                                                                  System hyperkalemia

                                                                  Gastrointestinal Nauseavomiting colic diarrhea

                                                                  Neuromuscular weakness paralysis respiratory failure

                                                                  Cardiovascular Arrhythmia arrest

                                                                  ECG changes Peaked T waves (early change)

                                                                  Flattened P wave

                                                                  Prolonged PR interval (first-degree block)

                                                                  Widened QRS complex

                                                                  Sine wave formation

                                                                  Ventricular fibrillation

                                                                  Treatment

                                                                  Treatment of symptomatic hyperkalemia

                                                                  Potassium removal Kayexalate

                                                                  Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                  Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                  Dialysis

                                                                  Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                  Bicarbonate 1 vial intravenous

                                                                  Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                  HypokalemiaEtiology

                                                                  inadequate intake

                                                                  Dietary potassium-free intravenous fluids potassium-deficient

                                                                  total parenteral nutrition

                                                                  Excessive potassium excretion

                                                                  Hyperaldosteronism

                                                                  Medications

                                                                  Gastrointestinal losses

                                                                  Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                  Renal loss of potassium (gastric fluid either as vomiting or high

                                                                  nasogastric output)

                                                                  Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                  Potassium changes associated with alkalosis

                                                                  Potassium decrease by 03 meqL for every 01

                                                                  increase in PH above normal

                                                                  Magnesium Depletion

                                                                  (drug induced amphotericin amioglycosides cisplatin)

                                                                  Renal potassium wastage

                                                                  Hypokalemia

                                                                  Magnesium Depletion

                                                                  (drug induced amphotericin amioglycosides cisplatin)

                                                                  Renal potassium wastage

                                                                  Hypokalemia

                                                                  Clinical Manifestation of Abnormalities in potassium

                                                                  System hypokalemia

                                                                  Gastrointestinal Ileus constipation

                                                                  Neuromuscular Decreased reflexes fatigue weakness

                                                                  paralysis

                                                                  Cardiovascular Arrest

                                                                  ECG changes U-waves

                                                                  T-wave flattening

                                                                  ST-segment changes

                                                                  Arrhythmias

                                                                  Treatment

                                                                  Potassium

                                                                  Serum potassium level lt40 mEqL

                                                                  Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                  times 1 doses

                                                                  Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                  Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                  Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                  asymptomatic replace as per above protocol

                                                                  Electrolyte Replacement Therapy Protocol

                                                                  bull Oral repletion for mild and asymptomatic hypokalemia

                                                                  bull IV repletion for severe and symptomatic hypokalemia

                                                                  Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                  ( دندانها( ndash استخوانbull كلسيم نقش

                                                                  عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                  صاف 2 عضالت انقباض

                                                                  هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                  انعقاد 4

                                                                  یونیزه Calt45 meql هيپوكلسمي

                                                                  عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                  ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                  میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                  ( شود می پیوند شده

                                                                  هیپوکلسمی عالئم

                                                                  رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                  سایرعالئم

                                                                  قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                  درمان

                                                                  ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                  Cagt55meql هيپركلسمي

                                                                  هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                  عالئم

                                                                  bullGI

                                                                  bullCardiovascular bullRenal (polyuria)

                                                                  bullCNS

                                                                  قلبی عالئم

                                                                  bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                  QRS شدن )Q-Tوكوتاه

                                                                  درمان

                                                                  ایزوتونیک 1 نمکی محلول انفوزیون

                                                                  الزیکس2

                                                                  تونین 3 کلسی

                                                                  کورتون4

                                                                  دیالیز5

                                                                  Magnesium Abnormalities

                                                                  Normal dietary intake 20meq (240mg)

                                                                  Excretion in both the feces and urine

                                                                  Normal serum level 19-25 mgdL

                                                                  منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                  تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                  bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                  Hypermagnesemia

                                                                  Etiology

                                                                  1 Impaired renal function

                                                                  2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                  Clinical manifestation hypermanesemia

                                                                  System hypermanesemia

                                                                  Gastrointestinal Nauseavomiting

                                                                  Neuromuscular weakness lethargy Decreased

                                                                  reflexes

                                                                  Cardiovascular Hypotension arrest

                                                                  ECG changes Increased PR interval

                                                                  Widened QRS complex

                                                                  Elevated T waves

                                                                  Treatment

                                                                  1 Withhold exogenous sources of magnesium

                                                                  2 Correct volume deficit

                                                                  3 Correct acidosis if present

                                                                  4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                  5 Dialysis (if elevated levels or symptoms persist)

                                                                  عالئم

                                                                  bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                  meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                  meqL

                                                                  Hypomagnesemia

                                                                  Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                  homeostasis

                                                                  Etiology

                                                                  1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                  inadequate supplementation of magnesium)

                                                                  2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                  3 GI losses (diarrhea)

                                                                  4 Malabsorption

                                                                  5 Acute pancreatitis

                                                                  6 Diabetic ketoacidosis

                                                                  7 Primary aldosteronism

                                                                  Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                  1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                  2 Delirium and seizures in severe deficiency

                                                                  3 ECG changes Prolonged QT and PR interval

                                                                  ST-segment depression

                                                                  Flattening or inversion of P waves

                                                                  Torsades de pointes

                                                                  Arrhythmia

                                                                  Treatment

                                                                  1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                  2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                  Message for Today

                                                                  ICF

                                                                  Interstitial

                                                                  Pla

                                                                  sma

                                                                  5 Dex

                                                                  bull Do not reccussitate sick patients with any Dextrose solution

                                                                  • Fluid and Electrolyte Management of the Surgical Patient
                                                                  • Slide 2
                                                                  • Slide 3
                                                                  • Slide 4
                                                                  • Total Body Water
                                                                  • Body Fluid Compartments
                                                                  • Total body water (TBW)
                                                                  • Body compartment fluid
                                                                  • Example men with 70kg
                                                                  • Fluid compartments
                                                                  • Slide 11
                                                                  • Slide 12
                                                                  • Slide 13
                                                                  • Slide 14
                                                                  • Slide 15
                                                                  • Colloid osmotic pressure
                                                                  • Slide 17
                                                                  • Slide 18
                                                                  • Slide 19
                                                                  • Cell Membrane
                                                                  • Slide 21
                                                                  • Slide 22
                                                                  • Slide 23
                                                                  • Slide 24
                                                                  • Slide 25
                                                                  • Composition of Fluid Compartments
                                                                  • Composition of Body Fluids
                                                                  • عوامل موثر روی تغییرات آب والکترولیت
                                                                  • Reasons for fluid therapy
                                                                  • ارزیابی حجم مایع داخل عروقی
                                                                  • محلولهای وریدی
                                                                  • Fluids
                                                                  • Slide 33
                                                                  • Slide 34
                                                                  • Slide 35
                                                                  • Crystalloids
                                                                  • Colloid Solutions
                                                                  • رینگر لاکتات
                                                                  • 09Nacl
                                                                  • Postoperative (maintenance)
                                                                  • Slide 41
                                                                  • Preexisting fluid deficits
                                                                  • Maintenance requirements
                                                                  • Surgical fluid losses
                                                                  • Third space loss
                                                                  • Crystalloid solution
                                                                  • Colloids
                                                                  • Complications
                                                                  • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                  • Colloid versus crystalloid solutions
                                                                  • Transfusion consideration
                                                                  • اختلال در حجم مایعات بدن
                                                                  • Fluid volume deficit (FVD)
                                                                  • DEHYDRATION
                                                                  • علل کاهش حجم خارج سلولی
                                                                  • Signs of Hypovolemia
                                                                  • Clinical Diagnosis of Hypovolemia
                                                                  • Signs of Hypervolemia
                                                                  • Management of Hypervolemia
                                                                  • Fluid Management
                                                                  • Electrolyte physiology
                                                                  • Sodium physiology
                                                                  • Osmotic Pressure
                                                                  • Concentration
                                                                  • Hypernatremia
                                                                  • - Hypernatremia
                                                                  • Slide 67
                                                                  • Slide 68
                                                                  • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                  • Treatment
                                                                  • Water deficit (L)= times TBW
                                                                  • The rate of fluid administration
                                                                  • Hyponatremia Nalt135mEqL
                                                                  • Slide 74
                                                                  • Sodium depletion
                                                                  • Sodium dilution
                                                                  • Sign and symptoms
                                                                  • Slide 78
                                                                  • Treatment
                                                                  • Slide 80
                                                                  • Slide 81
                                                                  • Dose
                                                                  • Potassium abnormalities
                                                                  • Hyperkalemia
                                                                  • Clinical manifestation of hyperkalemia
                                                                  • Slide 86
                                                                  • Slide 87
                                                                  • Hypokalemia
                                                                  • Potassium changes associated with alkalosis
                                                                  • Slide 90
                                                                  • Clinical Manifestation of Abnormalities in potassium
                                                                  • Slide 92
                                                                  • Calcium
                                                                  • هيپوكلسمي یونیزه Calt45 meql
                                                                  • علائم هیپوکلسمی
                                                                  • Slide 96
                                                                  • Slide 97
                                                                  • Slide 98
                                                                  • Slide 99
                                                                  • سایرعلائم
                                                                  • درمان
                                                                  • هيپركلسمي Cagt55meql
                                                                  • علائم
                                                                  • علائم قلبی
                                                                  • Slide 105
                                                                  • Magnesium Abnormalities
                                                                  • منیزیوم
                                                                  • Hypermagnesemia
                                                                  • Clinical manifestation hypermanesemia
                                                                  • Slide 110
                                                                  • Slide 111
                                                                  • Hypomagnesemia
                                                                  • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                  • Slide 114
                                                                  • Message for Today
                                                                  • Slide 116

                                                                    SolutionsSolutions VolumesVolumes NaNa++ KK++ CaCa2+2+ MgMg2+2+ ClCl-- HCOHCO33-- DextroseDextrose mOsmLmOsmL

                                                                    ECFECF 142 4 5 103 27 280-310

                                                                    Lactated Lactated RingerrsquosRingerrsquos

                                                                    130 4 3 109 28 273

                                                                    09 NaCl09 NaCl 154 154 308

                                                                    045 045 NaClNaCl

                                                                    77 77 154

                                                                    D5WD5W

                                                                    D5045 D5045 NaClNaCl

                                                                    77 77 50 406

                                                                    3 NaCl3 NaCl 513 513 1026

                                                                    6 6 HetastarchHetastarch

                                                                    500 154 154 310

                                                                    5 5 AlbuminAlbumin

                                                                    250500130-160

                                                                    lt25130-160

                                                                    330

                                                                    25 25 AlbuminAlbumin

                                                                    2050100130-160

                                                                    lt25130-160

                                                                    330

                                                                    Common parenteral fluid therapyCommon parenteral fluid therapy

                                                                    CrystalloidsCrystalloids

                                                                    bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                                                    Colloid SolutionsColloid Solutions

                                                                    bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                                                    - Haes-steril 10

                                                                    الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                                                    کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                                                    ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                                                    osm=273

                                                                    09Nacl

                                                                    bull Na=154

                                                                    bull CL= 154

                                                                    کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                                                    PH=56است

                                                                    Postoperative (maintenance)

                                                                    045Nacl +5 dextrose +KCL

                                                                    Perioperative management of fluid balance include

                                                                    1 Preoperative evaluation

                                                                    2 Intraoperative maintenance

                                                                    3 Replacement of fluid losses

                                                                    Preexisting fluid deficits

                                                                    bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                                                    bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                                                    Maintenance requirements

                                                                    bull Up to 10 kg = 4cckghr

                                                                    bull 11-20kg = add 2cckghr

                                                                    bull 21kg and above = add 1cckghr

                                                                    bull Insensible losses = 2cckghr

                                                                    Surgical fluid losses

                                                                    Blood loss (measurement)

                                                                    1 Suction container

                                                                    2 Surgical sponge

                                                                    3 Hct and tachycardia not specific

                                                                    4 ABG and UO if hypoperfusion occur

                                                                    5 Blood loss=31 with crystalloid

                                                                    Other losses (third space loss)

                                                                    Third space loss

                                                                    1 Minimal (herniorrapy) =2-4cckghr

                                                                    2 Moderate (cholecystectomy)=4-6cckghr

                                                                    3 Severe (bowel resection) = 6-8cckghr

                                                                    Crystalloid solution

                                                                    1 The main solutions is either glucose or saline

                                                                    2 Hypotonic or isotonic or hypertonic

                                                                    3 Safe nontoxic reaction free inexpensive

                                                                    4 Complication is edema if large volumes are needed

                                                                    5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                                    Colloids

                                                                    1 Albumin

                                                                    2 Hydroxyethyl starch

                                                                    3 Dextran

                                                                    Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                                    factor )These colloid is best avoided in patients with

                                                                    coagulopaty

                                                                    The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                                    1000cc

                                                                    500cc

                                                                    500cc

                                                                    500cc

                                                                    200

                                                                    600

                                                                    1000

                                                                    Lactated Ringers

                                                                    5 Albumin

                                                                    6 Hetastarch

                                                                    Whole blood

                                                                    Blood volumeInfusion volume

                                                                    Colloid versus crystalloid solutions

                                                                    Transfusion consideration

                                                                    bull HB lt7 mg dl increase CO

                                                                    bull Ideal Hb is 7-8 mgdl

                                                                    bull In IHD patients or pulmonary disease gt 10 mgdl

                                                                    بدن مایعات حجم در اختالل

                                                                    1 Fluid volume deficit

                                                                    2 Fluid volume excess

                                                                    Fluid volume deficit(FVD)

                                                                    ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                    کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                    ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                    باشد آن با همراه دیگری اختالل مگر

                                                                    DEHYDRATION

                                                                    سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                    سلولی خارج حجم کاهش علل

                                                                    1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                    2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                    کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                    Signs of HypovolemiaSigns of Hypovolemia

                                                                    bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                    Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                    bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                    Signs of HypervolemiaSigns of Hypervolemia

                                                                    bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                    Especially when hypo-albuminemia

                                                                    Management of Management of HypervolemiaHypervolemia

                                                                    bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                    Fluid ManagementFluid Management

                                                                    bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                    Electrolyte physiology

                                                                    Sodium physiology

                                                                    Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                    Normal amount 135-145 meql

                                                                    Osmotic Pressure

                                                                    Calculated serum osmolality =

                                                                    2 sodium+ glucose18 + BUN 28

                                                                    Osmolality = 290 mosm

                                                                    Concentration

                                                                    1Serum sodium concentration2Serum osmolarity

                                                                    bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                    drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                    DW5)

                                                                    Hypernatremia

                                                                    Serum Nagt145mEqL

                                                                    - Hypernatremia

                                                                    Loss of Free Water

                                                                    Gain of sodium in excess of water

                                                                    Hypernatremia

                                                                    -Hypernatremia Hypo volemic

                                                                    Hyper volemic

                                                                    Normo volemic

                                                                    Hypernatremia

                                                                    Volume Status

                                                                    Normal

                                                                    Nonrenal water loss

                                                                    Skin

                                                                    Gastrointestinal

                                                                    Renal water loss

                                                                    Renal disease

                                                                    Diuretics

                                                                    Diabetes insipidus

                                                                    High

                                                                    Iatrogenic sodium administration

                                                                    Mineralocorticoid excess

                                                                    Aldosteronism

                                                                    Cushingrsquos disease

                                                                    Congenital adrenal

                                                                    hyperplasia

                                                                    Low

                                                                    Nonrenal water loss

                                                                    Skin

                                                                    Gastrointestinal losses

                                                                    Renal water losses

                                                                    Renal (tubular) Diuretics

                                                                    Osmotic diuretics

                                                                    Diabetes insipidus

                                                                    Adrenal failure

                                                                    Asymptomatic

                                                                    Hypernatremia Symptomatic (Nagt160 meqL)

                                                                    Clinical Manifestations of Abnormalities in Serum Sodium

                                                                    Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                    Body system hypernatremia

                                                                    Treatment

                                                                    Normal saline in hypovolemic patients

                                                                    Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                    saline or entral water)

                                                                    Water deficit (L)= times TBW

                                                                    The formula used to estimate the amount of water required to correct hypernatremia

                                                                    Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                    Serum sodium-140

                                                                    140

                                                                    The rate of fluid administration

                                                                    1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                    2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                    Hyponatremia Nalt135mEqL

                                                                    Causes

                                                                    1 Sodium depletion

                                                                    2 Sodium dilution

                                                                    bull Incidence = 45

                                                                    bull After surgery=1

                                                                    bull Mortality = 2 times normal

                                                                    Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                    volume deficit

                                                                    Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                    Sign and symptoms

                                                                    bull CNS symptom when Nalt123 meql

                                                                    bull Cardiac symptom when Nalt100 meql

                                                                    For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                    Body System Hyponatremia

                                                                    central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                    reflexes seizures coma increased intracranial pressure

                                                                    Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                    Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                    Cardiovascular Hypertension and bradycardia if significant increases in

                                                                    intracranial pressure

                                                                    Tissue Lacrimation salivation

                                                                    Renal Oliguria

                                                                    Clinical Manifestations of Abnormalities in Serum Sodium

                                                                    Treatment

                                                                    1=Depend on ECF

                                                                    2=CNS sign

                                                                    Treatment

                                                                    1 Asymptomatic increase the sodium level by no more than

                                                                    05-1 meqLh to a maximum increase of 12 meqL per day

                                                                    2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                    more than 1meqL per hour until the serum Na level reaches 130

                                                                    meqL or neurologic symptoms are improved

                                                                    Rapid correction of hyponatremia

                                                                    Pontine myelinolysis

                                                                    Seizures weaknessparesis akinetic

                                                                    movements unresponsiveness

                                                                    Permanent brain damage

                                                                    Death

                                                                    Dose

                                                                    Na deficit meq =(140- Na meql) TBW

                                                                    باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                    شود اصالح آهسته سپس

                                                                    Potassium abnormalities

                                                                    bull The average dietary intake of potassium 50-100meqd

                                                                    bull The average renal excretion of potassium 10-700 meqd

                                                                    - 2 of the total body potassium in ECF (45meqL)

                                                                    - Factors that influence serum potassium

                                                                    1 Surgical stress

                                                                    2 Injury

                                                                    3 Acidosis

                                                                    4 Tissue catabolism

                                                                    Hyperkalemia

                                                                    The normal range of serum potassium 35-5 meqL

                                                                    Etiology of Hyperkalemia

                                                                    Increased intake Potassium supplementation

                                                                    Blood transfusions

                                                                    Endogenous loaddestruction

                                                                    hemolysis rhabdomyolysis

                                                                    cruch injury gastrointestinal hemorrhage

                                                                    Increased release Acidosis

                                                                    Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                    Renal insufficiencyfailure

                                                                    Clinical manifestation of hyperkalemia

                                                                    System hyperkalemia

                                                                    Gastrointestinal Nauseavomiting colic diarrhea

                                                                    Neuromuscular weakness paralysis respiratory failure

                                                                    Cardiovascular Arrhythmia arrest

                                                                    ECG changes Peaked T waves (early change)

                                                                    Flattened P wave

                                                                    Prolonged PR interval (first-degree block)

                                                                    Widened QRS complex

                                                                    Sine wave formation

                                                                    Ventricular fibrillation

                                                                    Treatment

                                                                    Treatment of symptomatic hyperkalemia

                                                                    Potassium removal Kayexalate

                                                                    Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                    Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                    Dialysis

                                                                    Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                    Bicarbonate 1 vial intravenous

                                                                    Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                    HypokalemiaEtiology

                                                                    inadequate intake

                                                                    Dietary potassium-free intravenous fluids potassium-deficient

                                                                    total parenteral nutrition

                                                                    Excessive potassium excretion

                                                                    Hyperaldosteronism

                                                                    Medications

                                                                    Gastrointestinal losses

                                                                    Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                    Renal loss of potassium (gastric fluid either as vomiting or high

                                                                    nasogastric output)

                                                                    Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                    Potassium changes associated with alkalosis

                                                                    Potassium decrease by 03 meqL for every 01

                                                                    increase in PH above normal

                                                                    Magnesium Depletion

                                                                    (drug induced amphotericin amioglycosides cisplatin)

                                                                    Renal potassium wastage

                                                                    Hypokalemia

                                                                    Magnesium Depletion

                                                                    (drug induced amphotericin amioglycosides cisplatin)

                                                                    Renal potassium wastage

                                                                    Hypokalemia

                                                                    Clinical Manifestation of Abnormalities in potassium

                                                                    System hypokalemia

                                                                    Gastrointestinal Ileus constipation

                                                                    Neuromuscular Decreased reflexes fatigue weakness

                                                                    paralysis

                                                                    Cardiovascular Arrest

                                                                    ECG changes U-waves

                                                                    T-wave flattening

                                                                    ST-segment changes

                                                                    Arrhythmias

                                                                    Treatment

                                                                    Potassium

                                                                    Serum potassium level lt40 mEqL

                                                                    Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                    times 1 doses

                                                                    Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                    Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                    Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                    asymptomatic replace as per above protocol

                                                                    Electrolyte Replacement Therapy Protocol

                                                                    bull Oral repletion for mild and asymptomatic hypokalemia

                                                                    bull IV repletion for severe and symptomatic hypokalemia

                                                                    Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                    ( دندانها( ndash استخوانbull كلسيم نقش

                                                                    عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                    صاف 2 عضالت انقباض

                                                                    هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                    انعقاد 4

                                                                    یونیزه Calt45 meql هيپوكلسمي

                                                                    عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                    ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                    میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                    ( شود می پیوند شده

                                                                    هیپوکلسمی عالئم

                                                                    رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                    سایرعالئم

                                                                    قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                    درمان

                                                                    ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                    Cagt55meql هيپركلسمي

                                                                    هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                    عالئم

                                                                    bullGI

                                                                    bullCardiovascular bullRenal (polyuria)

                                                                    bullCNS

                                                                    قلبی عالئم

                                                                    bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                    QRS شدن )Q-Tوكوتاه

                                                                    درمان

                                                                    ایزوتونیک 1 نمکی محلول انفوزیون

                                                                    الزیکس2

                                                                    تونین 3 کلسی

                                                                    کورتون4

                                                                    دیالیز5

                                                                    Magnesium Abnormalities

                                                                    Normal dietary intake 20meq (240mg)

                                                                    Excretion in both the feces and urine

                                                                    Normal serum level 19-25 mgdL

                                                                    منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                    تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                    bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                    Hypermagnesemia

                                                                    Etiology

                                                                    1 Impaired renal function

                                                                    2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                    Clinical manifestation hypermanesemia

                                                                    System hypermanesemia

                                                                    Gastrointestinal Nauseavomiting

                                                                    Neuromuscular weakness lethargy Decreased

                                                                    reflexes

                                                                    Cardiovascular Hypotension arrest

                                                                    ECG changes Increased PR interval

                                                                    Widened QRS complex

                                                                    Elevated T waves

                                                                    Treatment

                                                                    1 Withhold exogenous sources of magnesium

                                                                    2 Correct volume deficit

                                                                    3 Correct acidosis if present

                                                                    4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                    5 Dialysis (if elevated levels or symptoms persist)

                                                                    عالئم

                                                                    bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                    meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                    meqL

                                                                    Hypomagnesemia

                                                                    Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                    homeostasis

                                                                    Etiology

                                                                    1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                    inadequate supplementation of magnesium)

                                                                    2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                    3 GI losses (diarrhea)

                                                                    4 Malabsorption

                                                                    5 Acute pancreatitis

                                                                    6 Diabetic ketoacidosis

                                                                    7 Primary aldosteronism

                                                                    Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                    1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                    2 Delirium and seizures in severe deficiency

                                                                    3 ECG changes Prolonged QT and PR interval

                                                                    ST-segment depression

                                                                    Flattening or inversion of P waves

                                                                    Torsades de pointes

                                                                    Arrhythmia

                                                                    Treatment

                                                                    1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                    2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                    Message for Today

                                                                    ICF

                                                                    Interstitial

                                                                    Pla

                                                                    sma

                                                                    5 Dex

                                                                    bull Do not reccussitate sick patients with any Dextrose solution

                                                                    • Fluid and Electrolyte Management of the Surgical Patient
                                                                    • Slide 2
                                                                    • Slide 3
                                                                    • Slide 4
                                                                    • Total Body Water
                                                                    • Body Fluid Compartments
                                                                    • Total body water (TBW)
                                                                    • Body compartment fluid
                                                                    • Example men with 70kg
                                                                    • Fluid compartments
                                                                    • Slide 11
                                                                    • Slide 12
                                                                    • Slide 13
                                                                    • Slide 14
                                                                    • Slide 15
                                                                    • Colloid osmotic pressure
                                                                    • Slide 17
                                                                    • Slide 18
                                                                    • Slide 19
                                                                    • Cell Membrane
                                                                    • Slide 21
                                                                    • Slide 22
                                                                    • Slide 23
                                                                    • Slide 24
                                                                    • Slide 25
                                                                    • Composition of Fluid Compartments
                                                                    • Composition of Body Fluids
                                                                    • عوامل موثر روی تغییرات آب والکترولیت
                                                                    • Reasons for fluid therapy
                                                                    • ارزیابی حجم مایع داخل عروقی
                                                                    • محلولهای وریدی
                                                                    • Fluids
                                                                    • Slide 33
                                                                    • Slide 34
                                                                    • Slide 35
                                                                    • Crystalloids
                                                                    • Colloid Solutions
                                                                    • رینگر لاکتات
                                                                    • 09Nacl
                                                                    • Postoperative (maintenance)
                                                                    • Slide 41
                                                                    • Preexisting fluid deficits
                                                                    • Maintenance requirements
                                                                    • Surgical fluid losses
                                                                    • Third space loss
                                                                    • Crystalloid solution
                                                                    • Colloids
                                                                    • Complications
                                                                    • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                    • Colloid versus crystalloid solutions
                                                                    • Transfusion consideration
                                                                    • اختلال در حجم مایعات بدن
                                                                    • Fluid volume deficit (FVD)
                                                                    • DEHYDRATION
                                                                    • علل کاهش حجم خارج سلولی
                                                                    • Signs of Hypovolemia
                                                                    • Clinical Diagnosis of Hypovolemia
                                                                    • Signs of Hypervolemia
                                                                    • Management of Hypervolemia
                                                                    • Fluid Management
                                                                    • Electrolyte physiology
                                                                    • Sodium physiology
                                                                    • Osmotic Pressure
                                                                    • Concentration
                                                                    • Hypernatremia
                                                                    • - Hypernatremia
                                                                    • Slide 67
                                                                    • Slide 68
                                                                    • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                    • Treatment
                                                                    • Water deficit (L)= times TBW
                                                                    • The rate of fluid administration
                                                                    • Hyponatremia Nalt135mEqL
                                                                    • Slide 74
                                                                    • Sodium depletion
                                                                    • Sodium dilution
                                                                    • Sign and symptoms
                                                                    • Slide 78
                                                                    • Treatment
                                                                    • Slide 80
                                                                    • Slide 81
                                                                    • Dose
                                                                    • Potassium abnormalities
                                                                    • Hyperkalemia
                                                                    • Clinical manifestation of hyperkalemia
                                                                    • Slide 86
                                                                    • Slide 87
                                                                    • Hypokalemia
                                                                    • Potassium changes associated with alkalosis
                                                                    • Slide 90
                                                                    • Clinical Manifestation of Abnormalities in potassium
                                                                    • Slide 92
                                                                    • Calcium
                                                                    • هيپوكلسمي یونیزه Calt45 meql
                                                                    • علائم هیپوکلسمی
                                                                    • Slide 96
                                                                    • Slide 97
                                                                    • Slide 98
                                                                    • Slide 99
                                                                    • سایرعلائم
                                                                    • درمان
                                                                    • هيپركلسمي Cagt55meql
                                                                    • علائم
                                                                    • علائم قلبی
                                                                    • Slide 105
                                                                    • Magnesium Abnormalities
                                                                    • منیزیوم
                                                                    • Hypermagnesemia
                                                                    • Clinical manifestation hypermanesemia
                                                                    • Slide 110
                                                                    • Slide 111
                                                                    • Hypomagnesemia
                                                                    • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                    • Slide 114
                                                                    • Message for Today
                                                                    • Slide 116

                                                                      CrystalloidsCrystalloids

                                                                      bull Isotonic crystalloids - Lactated Ringerrsquos 09 NaCl - only 25 remain intravascularly bull Hypertonic saline solutions - 3 NaClbull Hypotonic solutions - D5W 045 NaCl - less than 10 remain intra- vascularly inadequate for fluid resuscitation

                                                                      Colloid SolutionsColloid Solutions

                                                                      bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                                                      - Haes-steril 10

                                                                      الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                                                      کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                                                      ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                                                      osm=273

                                                                      09Nacl

                                                                      bull Na=154

                                                                      bull CL= 154

                                                                      کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                                                      PH=56است

                                                                      Postoperative (maintenance)

                                                                      045Nacl +5 dextrose +KCL

                                                                      Perioperative management of fluid balance include

                                                                      1 Preoperative evaluation

                                                                      2 Intraoperative maintenance

                                                                      3 Replacement of fluid losses

                                                                      Preexisting fluid deficits

                                                                      bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                                                      bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                                                      Maintenance requirements

                                                                      bull Up to 10 kg = 4cckghr

                                                                      bull 11-20kg = add 2cckghr

                                                                      bull 21kg and above = add 1cckghr

                                                                      bull Insensible losses = 2cckghr

                                                                      Surgical fluid losses

                                                                      Blood loss (measurement)

                                                                      1 Suction container

                                                                      2 Surgical sponge

                                                                      3 Hct and tachycardia not specific

                                                                      4 ABG and UO if hypoperfusion occur

                                                                      5 Blood loss=31 with crystalloid

                                                                      Other losses (third space loss)

                                                                      Third space loss

                                                                      1 Minimal (herniorrapy) =2-4cckghr

                                                                      2 Moderate (cholecystectomy)=4-6cckghr

                                                                      3 Severe (bowel resection) = 6-8cckghr

                                                                      Crystalloid solution

                                                                      1 The main solutions is either glucose or saline

                                                                      2 Hypotonic or isotonic or hypertonic

                                                                      3 Safe nontoxic reaction free inexpensive

                                                                      4 Complication is edema if large volumes are needed

                                                                      5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                                      Colloids

                                                                      1 Albumin

                                                                      2 Hydroxyethyl starch

                                                                      3 Dextran

                                                                      Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                                      factor )These colloid is best avoided in patients with

                                                                      coagulopaty

                                                                      The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                                      1000cc

                                                                      500cc

                                                                      500cc

                                                                      500cc

                                                                      200

                                                                      600

                                                                      1000

                                                                      Lactated Ringers

                                                                      5 Albumin

                                                                      6 Hetastarch

                                                                      Whole blood

                                                                      Blood volumeInfusion volume

                                                                      Colloid versus crystalloid solutions

                                                                      Transfusion consideration

                                                                      bull HB lt7 mg dl increase CO

                                                                      bull Ideal Hb is 7-8 mgdl

                                                                      bull In IHD patients or pulmonary disease gt 10 mgdl

                                                                      بدن مایعات حجم در اختالل

                                                                      1 Fluid volume deficit

                                                                      2 Fluid volume excess

                                                                      Fluid volume deficit(FVD)

                                                                      ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                      کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                      ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                      باشد آن با همراه دیگری اختالل مگر

                                                                      DEHYDRATION

                                                                      سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                      سلولی خارج حجم کاهش علل

                                                                      1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                      2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                      کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                      Signs of HypovolemiaSigns of Hypovolemia

                                                                      bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                      Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                      bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                      Signs of HypervolemiaSigns of Hypervolemia

                                                                      bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                      Especially when hypo-albuminemia

                                                                      Management of Management of HypervolemiaHypervolemia

                                                                      bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                      Fluid ManagementFluid Management

                                                                      bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                      Electrolyte physiology

                                                                      Sodium physiology

                                                                      Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                      Normal amount 135-145 meql

                                                                      Osmotic Pressure

                                                                      Calculated serum osmolality =

                                                                      2 sodium+ glucose18 + BUN 28

                                                                      Osmolality = 290 mosm

                                                                      Concentration

                                                                      1Serum sodium concentration2Serum osmolarity

                                                                      bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                      drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                      DW5)

                                                                      Hypernatremia

                                                                      Serum Nagt145mEqL

                                                                      - Hypernatremia

                                                                      Loss of Free Water

                                                                      Gain of sodium in excess of water

                                                                      Hypernatremia

                                                                      -Hypernatremia Hypo volemic

                                                                      Hyper volemic

                                                                      Normo volemic

                                                                      Hypernatremia

                                                                      Volume Status

                                                                      Normal

                                                                      Nonrenal water loss

                                                                      Skin

                                                                      Gastrointestinal

                                                                      Renal water loss

                                                                      Renal disease

                                                                      Diuretics

                                                                      Diabetes insipidus

                                                                      High

                                                                      Iatrogenic sodium administration

                                                                      Mineralocorticoid excess

                                                                      Aldosteronism

                                                                      Cushingrsquos disease

                                                                      Congenital adrenal

                                                                      hyperplasia

                                                                      Low

                                                                      Nonrenal water loss

                                                                      Skin

                                                                      Gastrointestinal losses

                                                                      Renal water losses

                                                                      Renal (tubular) Diuretics

                                                                      Osmotic diuretics

                                                                      Diabetes insipidus

                                                                      Adrenal failure

                                                                      Asymptomatic

                                                                      Hypernatremia Symptomatic (Nagt160 meqL)

                                                                      Clinical Manifestations of Abnormalities in Serum Sodium

                                                                      Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                      Body system hypernatremia

                                                                      Treatment

                                                                      Normal saline in hypovolemic patients

                                                                      Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                      saline or entral water)

                                                                      Water deficit (L)= times TBW

                                                                      The formula used to estimate the amount of water required to correct hypernatremia

                                                                      Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                      Serum sodium-140

                                                                      140

                                                                      The rate of fluid administration

                                                                      1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                      2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                      Hyponatremia Nalt135mEqL

                                                                      Causes

                                                                      1 Sodium depletion

                                                                      2 Sodium dilution

                                                                      bull Incidence = 45

                                                                      bull After surgery=1

                                                                      bull Mortality = 2 times normal

                                                                      Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                      volume deficit

                                                                      Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                      Sign and symptoms

                                                                      bull CNS symptom when Nalt123 meql

                                                                      bull Cardiac symptom when Nalt100 meql

                                                                      For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                      Body System Hyponatremia

                                                                      central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                      reflexes seizures coma increased intracranial pressure

                                                                      Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                      Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                      Cardiovascular Hypertension and bradycardia if significant increases in

                                                                      intracranial pressure

                                                                      Tissue Lacrimation salivation

                                                                      Renal Oliguria

                                                                      Clinical Manifestations of Abnormalities in Serum Sodium

                                                                      Treatment

                                                                      1=Depend on ECF

                                                                      2=CNS sign

                                                                      Treatment

                                                                      1 Asymptomatic increase the sodium level by no more than

                                                                      05-1 meqLh to a maximum increase of 12 meqL per day

                                                                      2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                      more than 1meqL per hour until the serum Na level reaches 130

                                                                      meqL or neurologic symptoms are improved

                                                                      Rapid correction of hyponatremia

                                                                      Pontine myelinolysis

                                                                      Seizures weaknessparesis akinetic

                                                                      movements unresponsiveness

                                                                      Permanent brain damage

                                                                      Death

                                                                      Dose

                                                                      Na deficit meq =(140- Na meql) TBW

                                                                      باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                      شود اصالح آهسته سپس

                                                                      Potassium abnormalities

                                                                      bull The average dietary intake of potassium 50-100meqd

                                                                      bull The average renal excretion of potassium 10-700 meqd

                                                                      - 2 of the total body potassium in ECF (45meqL)

                                                                      - Factors that influence serum potassium

                                                                      1 Surgical stress

                                                                      2 Injury

                                                                      3 Acidosis

                                                                      4 Tissue catabolism

                                                                      Hyperkalemia

                                                                      The normal range of serum potassium 35-5 meqL

                                                                      Etiology of Hyperkalemia

                                                                      Increased intake Potassium supplementation

                                                                      Blood transfusions

                                                                      Endogenous loaddestruction

                                                                      hemolysis rhabdomyolysis

                                                                      cruch injury gastrointestinal hemorrhage

                                                                      Increased release Acidosis

                                                                      Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                      Renal insufficiencyfailure

                                                                      Clinical manifestation of hyperkalemia

                                                                      System hyperkalemia

                                                                      Gastrointestinal Nauseavomiting colic diarrhea

                                                                      Neuromuscular weakness paralysis respiratory failure

                                                                      Cardiovascular Arrhythmia arrest

                                                                      ECG changes Peaked T waves (early change)

                                                                      Flattened P wave

                                                                      Prolonged PR interval (first-degree block)

                                                                      Widened QRS complex

                                                                      Sine wave formation

                                                                      Ventricular fibrillation

                                                                      Treatment

                                                                      Treatment of symptomatic hyperkalemia

                                                                      Potassium removal Kayexalate

                                                                      Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                      Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                      Dialysis

                                                                      Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                      Bicarbonate 1 vial intravenous

                                                                      Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                      HypokalemiaEtiology

                                                                      inadequate intake

                                                                      Dietary potassium-free intravenous fluids potassium-deficient

                                                                      total parenteral nutrition

                                                                      Excessive potassium excretion

                                                                      Hyperaldosteronism

                                                                      Medications

                                                                      Gastrointestinal losses

                                                                      Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                      Renal loss of potassium (gastric fluid either as vomiting or high

                                                                      nasogastric output)

                                                                      Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                      Potassium changes associated with alkalosis

                                                                      Potassium decrease by 03 meqL for every 01

                                                                      increase in PH above normal

                                                                      Magnesium Depletion

                                                                      (drug induced amphotericin amioglycosides cisplatin)

                                                                      Renal potassium wastage

                                                                      Hypokalemia

                                                                      Magnesium Depletion

                                                                      (drug induced amphotericin amioglycosides cisplatin)

                                                                      Renal potassium wastage

                                                                      Hypokalemia

                                                                      Clinical Manifestation of Abnormalities in potassium

                                                                      System hypokalemia

                                                                      Gastrointestinal Ileus constipation

                                                                      Neuromuscular Decreased reflexes fatigue weakness

                                                                      paralysis

                                                                      Cardiovascular Arrest

                                                                      ECG changes U-waves

                                                                      T-wave flattening

                                                                      ST-segment changes

                                                                      Arrhythmias

                                                                      Treatment

                                                                      Potassium

                                                                      Serum potassium level lt40 mEqL

                                                                      Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                      times 1 doses

                                                                      Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                      Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                      Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                      asymptomatic replace as per above protocol

                                                                      Electrolyte Replacement Therapy Protocol

                                                                      bull Oral repletion for mild and asymptomatic hypokalemia

                                                                      bull IV repletion for severe and symptomatic hypokalemia

                                                                      Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                      ( دندانها( ndash استخوانbull كلسيم نقش

                                                                      عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                      صاف 2 عضالت انقباض

                                                                      هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                      انعقاد 4

                                                                      یونیزه Calt45 meql هيپوكلسمي

                                                                      عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                      ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                      میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                      ( شود می پیوند شده

                                                                      هیپوکلسمی عالئم

                                                                      رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                      سایرعالئم

                                                                      قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                      درمان

                                                                      ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                      Cagt55meql هيپركلسمي

                                                                      هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                      عالئم

                                                                      bullGI

                                                                      bullCardiovascular bullRenal (polyuria)

                                                                      bullCNS

                                                                      قلبی عالئم

                                                                      bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                      QRS شدن )Q-Tوكوتاه

                                                                      درمان

                                                                      ایزوتونیک 1 نمکی محلول انفوزیون

                                                                      الزیکس2

                                                                      تونین 3 کلسی

                                                                      کورتون4

                                                                      دیالیز5

                                                                      Magnesium Abnormalities

                                                                      Normal dietary intake 20meq (240mg)

                                                                      Excretion in both the feces and urine

                                                                      Normal serum level 19-25 mgdL

                                                                      منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                      تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                      bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                      Hypermagnesemia

                                                                      Etiology

                                                                      1 Impaired renal function

                                                                      2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                      Clinical manifestation hypermanesemia

                                                                      System hypermanesemia

                                                                      Gastrointestinal Nauseavomiting

                                                                      Neuromuscular weakness lethargy Decreased

                                                                      reflexes

                                                                      Cardiovascular Hypotension arrest

                                                                      ECG changes Increased PR interval

                                                                      Widened QRS complex

                                                                      Elevated T waves

                                                                      Treatment

                                                                      1 Withhold exogenous sources of magnesium

                                                                      2 Correct volume deficit

                                                                      3 Correct acidosis if present

                                                                      4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                      5 Dialysis (if elevated levels or symptoms persist)

                                                                      عالئم

                                                                      bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                      meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                      meqL

                                                                      Hypomagnesemia

                                                                      Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                      homeostasis

                                                                      Etiology

                                                                      1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                      inadequate supplementation of magnesium)

                                                                      2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                      3 GI losses (diarrhea)

                                                                      4 Malabsorption

                                                                      5 Acute pancreatitis

                                                                      6 Diabetic ketoacidosis

                                                                      7 Primary aldosteronism

                                                                      Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                      1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                      2 Delirium and seizures in severe deficiency

                                                                      3 ECG changes Prolonged QT and PR interval

                                                                      ST-segment depression

                                                                      Flattening or inversion of P waves

                                                                      Torsades de pointes

                                                                      Arrhythmia

                                                                      Treatment

                                                                      1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                      2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                      Message for Today

                                                                      ICF

                                                                      Interstitial

                                                                      Pla

                                                                      sma

                                                                      5 Dex

                                                                      bull Do not reccussitate sick patients with any Dextrose solution

                                                                      • Fluid and Electrolyte Management of the Surgical Patient
                                                                      • Slide 2
                                                                      • Slide 3
                                                                      • Slide 4
                                                                      • Total Body Water
                                                                      • Body Fluid Compartments
                                                                      • Total body water (TBW)
                                                                      • Body compartment fluid
                                                                      • Example men with 70kg
                                                                      • Fluid compartments
                                                                      • Slide 11
                                                                      • Slide 12
                                                                      • Slide 13
                                                                      • Slide 14
                                                                      • Slide 15
                                                                      • Colloid osmotic pressure
                                                                      • Slide 17
                                                                      • Slide 18
                                                                      • Slide 19
                                                                      • Cell Membrane
                                                                      • Slide 21
                                                                      • Slide 22
                                                                      • Slide 23
                                                                      • Slide 24
                                                                      • Slide 25
                                                                      • Composition of Fluid Compartments
                                                                      • Composition of Body Fluids
                                                                      • عوامل موثر روی تغییرات آب والکترولیت
                                                                      • Reasons for fluid therapy
                                                                      • ارزیابی حجم مایع داخل عروقی
                                                                      • محلولهای وریدی
                                                                      • Fluids
                                                                      • Slide 33
                                                                      • Slide 34
                                                                      • Slide 35
                                                                      • Crystalloids
                                                                      • Colloid Solutions
                                                                      • رینگر لاکتات
                                                                      • 09Nacl
                                                                      • Postoperative (maintenance)
                                                                      • Slide 41
                                                                      • Preexisting fluid deficits
                                                                      • Maintenance requirements
                                                                      • Surgical fluid losses
                                                                      • Third space loss
                                                                      • Crystalloid solution
                                                                      • Colloids
                                                                      • Complications
                                                                      • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                      • Colloid versus crystalloid solutions
                                                                      • Transfusion consideration
                                                                      • اختلال در حجم مایعات بدن
                                                                      • Fluid volume deficit (FVD)
                                                                      • DEHYDRATION
                                                                      • علل کاهش حجم خارج سلولی
                                                                      • Signs of Hypovolemia
                                                                      • Clinical Diagnosis of Hypovolemia
                                                                      • Signs of Hypervolemia
                                                                      • Management of Hypervolemia
                                                                      • Fluid Management
                                                                      • Electrolyte physiology
                                                                      • Sodium physiology
                                                                      • Osmotic Pressure
                                                                      • Concentration
                                                                      • Hypernatremia
                                                                      • - Hypernatremia
                                                                      • Slide 67
                                                                      • Slide 68
                                                                      • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                      • Treatment
                                                                      • Water deficit (L)= times TBW
                                                                      • The rate of fluid administration
                                                                      • Hyponatremia Nalt135mEqL
                                                                      • Slide 74
                                                                      • Sodium depletion
                                                                      • Sodium dilution
                                                                      • Sign and symptoms
                                                                      • Slide 78
                                                                      • Treatment
                                                                      • Slide 80
                                                                      • Slide 81
                                                                      • Dose
                                                                      • Potassium abnormalities
                                                                      • Hyperkalemia
                                                                      • Clinical manifestation of hyperkalemia
                                                                      • Slide 86
                                                                      • Slide 87
                                                                      • Hypokalemia
                                                                      • Potassium changes associated with alkalosis
                                                                      • Slide 90
                                                                      • Clinical Manifestation of Abnormalities in potassium
                                                                      • Slide 92
                                                                      • Calcium
                                                                      • هيپوكلسمي یونیزه Calt45 meql
                                                                      • علائم هیپوکلسمی
                                                                      • Slide 96
                                                                      • Slide 97
                                                                      • Slide 98
                                                                      • Slide 99
                                                                      • سایرعلائم
                                                                      • درمان
                                                                      • هيپركلسمي Cagt55meql
                                                                      • علائم
                                                                      • علائم قلبی
                                                                      • Slide 105
                                                                      • Magnesium Abnormalities
                                                                      • منیزیوم
                                                                      • Hypermagnesemia
                                                                      • Clinical manifestation hypermanesemia
                                                                      • Slide 110
                                                                      • Slide 111
                                                                      • Hypomagnesemia
                                                                      • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                      • Slide 114
                                                                      • Message for Today
                                                                      • Slide 116

                                                                        Colloid SolutionsColloid Solutions

                                                                        bull Contain high molecular weight substancesdo not readily migrate across capillary wallsbull Preparations - Albumin 5 25 - Dextran - Gelifundol

                                                                        - Haes-steril 10

                                                                        الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                                                        کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                                                        ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                                                        osm=273

                                                                        09Nacl

                                                                        bull Na=154

                                                                        bull CL= 154

                                                                        کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                                                        PH=56است

                                                                        Postoperative (maintenance)

                                                                        045Nacl +5 dextrose +KCL

                                                                        Perioperative management of fluid balance include

                                                                        1 Preoperative evaluation

                                                                        2 Intraoperative maintenance

                                                                        3 Replacement of fluid losses

                                                                        Preexisting fluid deficits

                                                                        bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                                                        bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                                                        Maintenance requirements

                                                                        bull Up to 10 kg = 4cckghr

                                                                        bull 11-20kg = add 2cckghr

                                                                        bull 21kg and above = add 1cckghr

                                                                        bull Insensible losses = 2cckghr

                                                                        Surgical fluid losses

                                                                        Blood loss (measurement)

                                                                        1 Suction container

                                                                        2 Surgical sponge

                                                                        3 Hct and tachycardia not specific

                                                                        4 ABG and UO if hypoperfusion occur

                                                                        5 Blood loss=31 with crystalloid

                                                                        Other losses (third space loss)

                                                                        Third space loss

                                                                        1 Minimal (herniorrapy) =2-4cckghr

                                                                        2 Moderate (cholecystectomy)=4-6cckghr

                                                                        3 Severe (bowel resection) = 6-8cckghr

                                                                        Crystalloid solution

                                                                        1 The main solutions is either glucose or saline

                                                                        2 Hypotonic or isotonic or hypertonic

                                                                        3 Safe nontoxic reaction free inexpensive

                                                                        4 Complication is edema if large volumes are needed

                                                                        5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                                        Colloids

                                                                        1 Albumin

                                                                        2 Hydroxyethyl starch

                                                                        3 Dextran

                                                                        Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                                        factor )These colloid is best avoided in patients with

                                                                        coagulopaty

                                                                        The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                                        1000cc

                                                                        500cc

                                                                        500cc

                                                                        500cc

                                                                        200

                                                                        600

                                                                        1000

                                                                        Lactated Ringers

                                                                        5 Albumin

                                                                        6 Hetastarch

                                                                        Whole blood

                                                                        Blood volumeInfusion volume

                                                                        Colloid versus crystalloid solutions

                                                                        Transfusion consideration

                                                                        bull HB lt7 mg dl increase CO

                                                                        bull Ideal Hb is 7-8 mgdl

                                                                        bull In IHD patients or pulmonary disease gt 10 mgdl

                                                                        بدن مایعات حجم در اختالل

                                                                        1 Fluid volume deficit

                                                                        2 Fluid volume excess

                                                                        Fluid volume deficit(FVD)

                                                                        ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                        کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                        ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                        باشد آن با همراه دیگری اختالل مگر

                                                                        DEHYDRATION

                                                                        سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                        سلولی خارج حجم کاهش علل

                                                                        1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                        2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                        کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                        Signs of HypovolemiaSigns of Hypovolemia

                                                                        bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                        Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                        bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                        Signs of HypervolemiaSigns of Hypervolemia

                                                                        bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                        Especially when hypo-albuminemia

                                                                        Management of Management of HypervolemiaHypervolemia

                                                                        bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                        Fluid ManagementFluid Management

                                                                        bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                        Electrolyte physiology

                                                                        Sodium physiology

                                                                        Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                        Normal amount 135-145 meql

                                                                        Osmotic Pressure

                                                                        Calculated serum osmolality =

                                                                        2 sodium+ glucose18 + BUN 28

                                                                        Osmolality = 290 mosm

                                                                        Concentration

                                                                        1Serum sodium concentration2Serum osmolarity

                                                                        bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                        drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                        DW5)

                                                                        Hypernatremia

                                                                        Serum Nagt145mEqL

                                                                        - Hypernatremia

                                                                        Loss of Free Water

                                                                        Gain of sodium in excess of water

                                                                        Hypernatremia

                                                                        -Hypernatremia Hypo volemic

                                                                        Hyper volemic

                                                                        Normo volemic

                                                                        Hypernatremia

                                                                        Volume Status

                                                                        Normal

                                                                        Nonrenal water loss

                                                                        Skin

                                                                        Gastrointestinal

                                                                        Renal water loss

                                                                        Renal disease

                                                                        Diuretics

                                                                        Diabetes insipidus

                                                                        High

                                                                        Iatrogenic sodium administration

                                                                        Mineralocorticoid excess

                                                                        Aldosteronism

                                                                        Cushingrsquos disease

                                                                        Congenital adrenal

                                                                        hyperplasia

                                                                        Low

                                                                        Nonrenal water loss

                                                                        Skin

                                                                        Gastrointestinal losses

                                                                        Renal water losses

                                                                        Renal (tubular) Diuretics

                                                                        Osmotic diuretics

                                                                        Diabetes insipidus

                                                                        Adrenal failure

                                                                        Asymptomatic

                                                                        Hypernatremia Symptomatic (Nagt160 meqL)

                                                                        Clinical Manifestations of Abnormalities in Serum Sodium

                                                                        Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                        Body system hypernatremia

                                                                        Treatment

                                                                        Normal saline in hypovolemic patients

                                                                        Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                        saline or entral water)

                                                                        Water deficit (L)= times TBW

                                                                        The formula used to estimate the amount of water required to correct hypernatremia

                                                                        Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                        Serum sodium-140

                                                                        140

                                                                        The rate of fluid administration

                                                                        1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                        2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                        Hyponatremia Nalt135mEqL

                                                                        Causes

                                                                        1 Sodium depletion

                                                                        2 Sodium dilution

                                                                        bull Incidence = 45

                                                                        bull After surgery=1

                                                                        bull Mortality = 2 times normal

                                                                        Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                        volume deficit

                                                                        Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                        Sign and symptoms

                                                                        bull CNS symptom when Nalt123 meql

                                                                        bull Cardiac symptom when Nalt100 meql

                                                                        For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                        Body System Hyponatremia

                                                                        central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                        reflexes seizures coma increased intracranial pressure

                                                                        Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                        Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                        Cardiovascular Hypertension and bradycardia if significant increases in

                                                                        intracranial pressure

                                                                        Tissue Lacrimation salivation

                                                                        Renal Oliguria

                                                                        Clinical Manifestations of Abnormalities in Serum Sodium

                                                                        Treatment

                                                                        1=Depend on ECF

                                                                        2=CNS sign

                                                                        Treatment

                                                                        1 Asymptomatic increase the sodium level by no more than

                                                                        05-1 meqLh to a maximum increase of 12 meqL per day

                                                                        2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                        more than 1meqL per hour until the serum Na level reaches 130

                                                                        meqL or neurologic symptoms are improved

                                                                        Rapid correction of hyponatremia

                                                                        Pontine myelinolysis

                                                                        Seizures weaknessparesis akinetic

                                                                        movements unresponsiveness

                                                                        Permanent brain damage

                                                                        Death

                                                                        Dose

                                                                        Na deficit meq =(140- Na meql) TBW

                                                                        باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                        شود اصالح آهسته سپس

                                                                        Potassium abnormalities

                                                                        bull The average dietary intake of potassium 50-100meqd

                                                                        bull The average renal excretion of potassium 10-700 meqd

                                                                        - 2 of the total body potassium in ECF (45meqL)

                                                                        - Factors that influence serum potassium

                                                                        1 Surgical stress

                                                                        2 Injury

                                                                        3 Acidosis

                                                                        4 Tissue catabolism

                                                                        Hyperkalemia

                                                                        The normal range of serum potassium 35-5 meqL

                                                                        Etiology of Hyperkalemia

                                                                        Increased intake Potassium supplementation

                                                                        Blood transfusions

                                                                        Endogenous loaddestruction

                                                                        hemolysis rhabdomyolysis

                                                                        cruch injury gastrointestinal hemorrhage

                                                                        Increased release Acidosis

                                                                        Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                        Renal insufficiencyfailure

                                                                        Clinical manifestation of hyperkalemia

                                                                        System hyperkalemia

                                                                        Gastrointestinal Nauseavomiting colic diarrhea

                                                                        Neuromuscular weakness paralysis respiratory failure

                                                                        Cardiovascular Arrhythmia arrest

                                                                        ECG changes Peaked T waves (early change)

                                                                        Flattened P wave

                                                                        Prolonged PR interval (first-degree block)

                                                                        Widened QRS complex

                                                                        Sine wave formation

                                                                        Ventricular fibrillation

                                                                        Treatment

                                                                        Treatment of symptomatic hyperkalemia

                                                                        Potassium removal Kayexalate

                                                                        Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                        Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                        Dialysis

                                                                        Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                        Bicarbonate 1 vial intravenous

                                                                        Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                        HypokalemiaEtiology

                                                                        inadequate intake

                                                                        Dietary potassium-free intravenous fluids potassium-deficient

                                                                        total parenteral nutrition

                                                                        Excessive potassium excretion

                                                                        Hyperaldosteronism

                                                                        Medications

                                                                        Gastrointestinal losses

                                                                        Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                        Renal loss of potassium (gastric fluid either as vomiting or high

                                                                        nasogastric output)

                                                                        Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                        Potassium changes associated with alkalosis

                                                                        Potassium decrease by 03 meqL for every 01

                                                                        increase in PH above normal

                                                                        Magnesium Depletion

                                                                        (drug induced amphotericin amioglycosides cisplatin)

                                                                        Renal potassium wastage

                                                                        Hypokalemia

                                                                        Magnesium Depletion

                                                                        (drug induced amphotericin amioglycosides cisplatin)

                                                                        Renal potassium wastage

                                                                        Hypokalemia

                                                                        Clinical Manifestation of Abnormalities in potassium

                                                                        System hypokalemia

                                                                        Gastrointestinal Ileus constipation

                                                                        Neuromuscular Decreased reflexes fatigue weakness

                                                                        paralysis

                                                                        Cardiovascular Arrest

                                                                        ECG changes U-waves

                                                                        T-wave flattening

                                                                        ST-segment changes

                                                                        Arrhythmias

                                                                        Treatment

                                                                        Potassium

                                                                        Serum potassium level lt40 mEqL

                                                                        Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                        times 1 doses

                                                                        Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                        Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                        Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                        asymptomatic replace as per above protocol

                                                                        Electrolyte Replacement Therapy Protocol

                                                                        bull Oral repletion for mild and asymptomatic hypokalemia

                                                                        bull IV repletion for severe and symptomatic hypokalemia

                                                                        Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                        ( دندانها( ndash استخوانbull كلسيم نقش

                                                                        عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                        صاف 2 عضالت انقباض

                                                                        هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                        انعقاد 4

                                                                        یونیزه Calt45 meql هيپوكلسمي

                                                                        عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                        ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                        میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                        ( شود می پیوند شده

                                                                        هیپوکلسمی عالئم

                                                                        رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                        سایرعالئم

                                                                        قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                        درمان

                                                                        ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                        Cagt55meql هيپركلسمي

                                                                        هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                        عالئم

                                                                        bullGI

                                                                        bullCardiovascular bullRenal (polyuria)

                                                                        bullCNS

                                                                        قلبی عالئم

                                                                        bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                        QRS شدن )Q-Tوكوتاه

                                                                        درمان

                                                                        ایزوتونیک 1 نمکی محلول انفوزیون

                                                                        الزیکس2

                                                                        تونین 3 کلسی

                                                                        کورتون4

                                                                        دیالیز5

                                                                        Magnesium Abnormalities

                                                                        Normal dietary intake 20meq (240mg)

                                                                        Excretion in both the feces and urine

                                                                        Normal serum level 19-25 mgdL

                                                                        منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                        تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                        bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                        Hypermagnesemia

                                                                        Etiology

                                                                        1 Impaired renal function

                                                                        2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                        Clinical manifestation hypermanesemia

                                                                        System hypermanesemia

                                                                        Gastrointestinal Nauseavomiting

                                                                        Neuromuscular weakness lethargy Decreased

                                                                        reflexes

                                                                        Cardiovascular Hypotension arrest

                                                                        ECG changes Increased PR interval

                                                                        Widened QRS complex

                                                                        Elevated T waves

                                                                        Treatment

                                                                        1 Withhold exogenous sources of magnesium

                                                                        2 Correct volume deficit

                                                                        3 Correct acidosis if present

                                                                        4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                        5 Dialysis (if elevated levels or symptoms persist)

                                                                        عالئم

                                                                        bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                        meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                        meqL

                                                                        Hypomagnesemia

                                                                        Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                        homeostasis

                                                                        Etiology

                                                                        1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                        inadequate supplementation of magnesium)

                                                                        2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                        3 GI losses (diarrhea)

                                                                        4 Malabsorption

                                                                        5 Acute pancreatitis

                                                                        6 Diabetic ketoacidosis

                                                                        7 Primary aldosteronism

                                                                        Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                        1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                        2 Delirium and seizures in severe deficiency

                                                                        3 ECG changes Prolonged QT and PR interval

                                                                        ST-segment depression

                                                                        Flattening or inversion of P waves

                                                                        Torsades de pointes

                                                                        Arrhythmia

                                                                        Treatment

                                                                        1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                        2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                        Message for Today

                                                                        ICF

                                                                        Interstitial

                                                                        Pla

                                                                        sma

                                                                        5 Dex

                                                                        bull Do not reccussitate sick patients with any Dextrose solution

                                                                        • Fluid and Electrolyte Management of the Surgical Patient
                                                                        • Slide 2
                                                                        • Slide 3
                                                                        • Slide 4
                                                                        • Total Body Water
                                                                        • Body Fluid Compartments
                                                                        • Total body water (TBW)
                                                                        • Body compartment fluid
                                                                        • Example men with 70kg
                                                                        • Fluid compartments
                                                                        • Slide 11
                                                                        • Slide 12
                                                                        • Slide 13
                                                                        • Slide 14
                                                                        • Slide 15
                                                                        • Colloid osmotic pressure
                                                                        • Slide 17
                                                                        • Slide 18
                                                                        • Slide 19
                                                                        • Cell Membrane
                                                                        • Slide 21
                                                                        • Slide 22
                                                                        • Slide 23
                                                                        • Slide 24
                                                                        • Slide 25
                                                                        • Composition of Fluid Compartments
                                                                        • Composition of Body Fluids
                                                                        • عوامل موثر روی تغییرات آب والکترولیت
                                                                        • Reasons for fluid therapy
                                                                        • ارزیابی حجم مایع داخل عروقی
                                                                        • محلولهای وریدی
                                                                        • Fluids
                                                                        • Slide 33
                                                                        • Slide 34
                                                                        • Slide 35
                                                                        • Crystalloids
                                                                        • Colloid Solutions
                                                                        • رینگر لاکتات
                                                                        • 09Nacl
                                                                        • Postoperative (maintenance)
                                                                        • Slide 41
                                                                        • Preexisting fluid deficits
                                                                        • Maintenance requirements
                                                                        • Surgical fluid losses
                                                                        • Third space loss
                                                                        • Crystalloid solution
                                                                        • Colloids
                                                                        • Complications
                                                                        • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                        • Colloid versus crystalloid solutions
                                                                        • Transfusion consideration
                                                                        • اختلال در حجم مایعات بدن
                                                                        • Fluid volume deficit (FVD)
                                                                        • DEHYDRATION
                                                                        • علل کاهش حجم خارج سلولی
                                                                        • Signs of Hypovolemia
                                                                        • Clinical Diagnosis of Hypovolemia
                                                                        • Signs of Hypervolemia
                                                                        • Management of Hypervolemia
                                                                        • Fluid Management
                                                                        • Electrolyte physiology
                                                                        • Sodium physiology
                                                                        • Osmotic Pressure
                                                                        • Concentration
                                                                        • Hypernatremia
                                                                        • - Hypernatremia
                                                                        • Slide 67
                                                                        • Slide 68
                                                                        • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                        • Treatment
                                                                        • Water deficit (L)= times TBW
                                                                        • The rate of fluid administration
                                                                        • Hyponatremia Nalt135mEqL
                                                                        • Slide 74
                                                                        • Sodium depletion
                                                                        • Sodium dilution
                                                                        • Sign and symptoms
                                                                        • Slide 78
                                                                        • Treatment
                                                                        • Slide 80
                                                                        • Slide 81
                                                                        • Dose
                                                                        • Potassium abnormalities
                                                                        • Hyperkalemia
                                                                        • Clinical manifestation of hyperkalemia
                                                                        • Slide 86
                                                                        • Slide 87
                                                                        • Hypokalemia
                                                                        • Potassium changes associated with alkalosis
                                                                        • Slide 90
                                                                        • Clinical Manifestation of Abnormalities in potassium
                                                                        • Slide 92
                                                                        • Calcium
                                                                        • هيپوكلسمي یونیزه Calt45 meql
                                                                        • علائم هیپوکلسمی
                                                                        • Slide 96
                                                                        • Slide 97
                                                                        • Slide 98
                                                                        • Slide 99
                                                                        • سایرعلائم
                                                                        • درمان
                                                                        • هيپركلسمي Cagt55meql
                                                                        • علائم
                                                                        • علائم قلبی
                                                                        • Slide 105
                                                                        • Magnesium Abnormalities
                                                                        • منیزیوم
                                                                        • Hypermagnesemia
                                                                        • Clinical manifestation hypermanesemia
                                                                        • Slide 110
                                                                        • Slide 111
                                                                        • Hypomagnesemia
                                                                        • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                        • Slide 114
                                                                        • Message for Today
                                                                        • Slide 116

                                                                          الکتات رینگردست bull از جایگزینی جهت ایزوتونیک نمکی مایع

                                                                          کاهش GIدادنهای در ECFو عمده اشکاالت بدون است الکتات رینگر اجزا و ترکیبات

                                                                          ایزوتونیک bullbullNa=130meql CL=109meql lactat=28meql

                                                                          osm=273

                                                                          09Nacl

                                                                          bull Na=154

                                                                          bull CL= 154

                                                                          کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                                                          PH=56است

                                                                          Postoperative (maintenance)

                                                                          045Nacl +5 dextrose +KCL

                                                                          Perioperative management of fluid balance include

                                                                          1 Preoperative evaluation

                                                                          2 Intraoperative maintenance

                                                                          3 Replacement of fluid losses

                                                                          Preexisting fluid deficits

                                                                          bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                                                          bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                                                          Maintenance requirements

                                                                          bull Up to 10 kg = 4cckghr

                                                                          bull 11-20kg = add 2cckghr

                                                                          bull 21kg and above = add 1cckghr

                                                                          bull Insensible losses = 2cckghr

                                                                          Surgical fluid losses

                                                                          Blood loss (measurement)

                                                                          1 Suction container

                                                                          2 Surgical sponge

                                                                          3 Hct and tachycardia not specific

                                                                          4 ABG and UO if hypoperfusion occur

                                                                          5 Blood loss=31 with crystalloid

                                                                          Other losses (third space loss)

                                                                          Third space loss

                                                                          1 Minimal (herniorrapy) =2-4cckghr

                                                                          2 Moderate (cholecystectomy)=4-6cckghr

                                                                          3 Severe (bowel resection) = 6-8cckghr

                                                                          Crystalloid solution

                                                                          1 The main solutions is either glucose or saline

                                                                          2 Hypotonic or isotonic or hypertonic

                                                                          3 Safe nontoxic reaction free inexpensive

                                                                          4 Complication is edema if large volumes are needed

                                                                          5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                                          Colloids

                                                                          1 Albumin

                                                                          2 Hydroxyethyl starch

                                                                          3 Dextran

                                                                          Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                                          factor )These colloid is best avoided in patients with

                                                                          coagulopaty

                                                                          The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                                          1000cc

                                                                          500cc

                                                                          500cc

                                                                          500cc

                                                                          200

                                                                          600

                                                                          1000

                                                                          Lactated Ringers

                                                                          5 Albumin

                                                                          6 Hetastarch

                                                                          Whole blood

                                                                          Blood volumeInfusion volume

                                                                          Colloid versus crystalloid solutions

                                                                          Transfusion consideration

                                                                          bull HB lt7 mg dl increase CO

                                                                          bull Ideal Hb is 7-8 mgdl

                                                                          bull In IHD patients or pulmonary disease gt 10 mgdl

                                                                          بدن مایعات حجم در اختالل

                                                                          1 Fluid volume deficit

                                                                          2 Fluid volume excess

                                                                          Fluid volume deficit(FVD)

                                                                          ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                          کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                          ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                          باشد آن با همراه دیگری اختالل مگر

                                                                          DEHYDRATION

                                                                          سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                          سلولی خارج حجم کاهش علل

                                                                          1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                          2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                          کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                          Signs of HypovolemiaSigns of Hypovolemia

                                                                          bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                          Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                          bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                          Signs of HypervolemiaSigns of Hypervolemia

                                                                          bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                          Especially when hypo-albuminemia

                                                                          Management of Management of HypervolemiaHypervolemia

                                                                          bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                          Fluid ManagementFluid Management

                                                                          bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                          Electrolyte physiology

                                                                          Sodium physiology

                                                                          Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                          Normal amount 135-145 meql

                                                                          Osmotic Pressure

                                                                          Calculated serum osmolality =

                                                                          2 sodium+ glucose18 + BUN 28

                                                                          Osmolality = 290 mosm

                                                                          Concentration

                                                                          1Serum sodium concentration2Serum osmolarity

                                                                          bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                          drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                          DW5)

                                                                          Hypernatremia

                                                                          Serum Nagt145mEqL

                                                                          - Hypernatremia

                                                                          Loss of Free Water

                                                                          Gain of sodium in excess of water

                                                                          Hypernatremia

                                                                          -Hypernatremia Hypo volemic

                                                                          Hyper volemic

                                                                          Normo volemic

                                                                          Hypernatremia

                                                                          Volume Status

                                                                          Normal

                                                                          Nonrenal water loss

                                                                          Skin

                                                                          Gastrointestinal

                                                                          Renal water loss

                                                                          Renal disease

                                                                          Diuretics

                                                                          Diabetes insipidus

                                                                          High

                                                                          Iatrogenic sodium administration

                                                                          Mineralocorticoid excess

                                                                          Aldosteronism

                                                                          Cushingrsquos disease

                                                                          Congenital adrenal

                                                                          hyperplasia

                                                                          Low

                                                                          Nonrenal water loss

                                                                          Skin

                                                                          Gastrointestinal losses

                                                                          Renal water losses

                                                                          Renal (tubular) Diuretics

                                                                          Osmotic diuretics

                                                                          Diabetes insipidus

                                                                          Adrenal failure

                                                                          Asymptomatic

                                                                          Hypernatremia Symptomatic (Nagt160 meqL)

                                                                          Clinical Manifestations of Abnormalities in Serum Sodium

                                                                          Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                          Body system hypernatremia

                                                                          Treatment

                                                                          Normal saline in hypovolemic patients

                                                                          Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                          saline or entral water)

                                                                          Water deficit (L)= times TBW

                                                                          The formula used to estimate the amount of water required to correct hypernatremia

                                                                          Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                          Serum sodium-140

                                                                          140

                                                                          The rate of fluid administration

                                                                          1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                          2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                          Hyponatremia Nalt135mEqL

                                                                          Causes

                                                                          1 Sodium depletion

                                                                          2 Sodium dilution

                                                                          bull Incidence = 45

                                                                          bull After surgery=1

                                                                          bull Mortality = 2 times normal

                                                                          Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                          volume deficit

                                                                          Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                          Sign and symptoms

                                                                          bull CNS symptom when Nalt123 meql

                                                                          bull Cardiac symptom when Nalt100 meql

                                                                          For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                          Body System Hyponatremia

                                                                          central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                          reflexes seizures coma increased intracranial pressure

                                                                          Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                          Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                          Cardiovascular Hypertension and bradycardia if significant increases in

                                                                          intracranial pressure

                                                                          Tissue Lacrimation salivation

                                                                          Renal Oliguria

                                                                          Clinical Manifestations of Abnormalities in Serum Sodium

                                                                          Treatment

                                                                          1=Depend on ECF

                                                                          2=CNS sign

                                                                          Treatment

                                                                          1 Asymptomatic increase the sodium level by no more than

                                                                          05-1 meqLh to a maximum increase of 12 meqL per day

                                                                          2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                          more than 1meqL per hour until the serum Na level reaches 130

                                                                          meqL or neurologic symptoms are improved

                                                                          Rapid correction of hyponatremia

                                                                          Pontine myelinolysis

                                                                          Seizures weaknessparesis akinetic

                                                                          movements unresponsiveness

                                                                          Permanent brain damage

                                                                          Death

                                                                          Dose

                                                                          Na deficit meq =(140- Na meql) TBW

                                                                          باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                          شود اصالح آهسته سپس

                                                                          Potassium abnormalities

                                                                          bull The average dietary intake of potassium 50-100meqd

                                                                          bull The average renal excretion of potassium 10-700 meqd

                                                                          - 2 of the total body potassium in ECF (45meqL)

                                                                          - Factors that influence serum potassium

                                                                          1 Surgical stress

                                                                          2 Injury

                                                                          3 Acidosis

                                                                          4 Tissue catabolism

                                                                          Hyperkalemia

                                                                          The normal range of serum potassium 35-5 meqL

                                                                          Etiology of Hyperkalemia

                                                                          Increased intake Potassium supplementation

                                                                          Blood transfusions

                                                                          Endogenous loaddestruction

                                                                          hemolysis rhabdomyolysis

                                                                          cruch injury gastrointestinal hemorrhage

                                                                          Increased release Acidosis

                                                                          Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                          Renal insufficiencyfailure

                                                                          Clinical manifestation of hyperkalemia

                                                                          System hyperkalemia

                                                                          Gastrointestinal Nauseavomiting colic diarrhea

                                                                          Neuromuscular weakness paralysis respiratory failure

                                                                          Cardiovascular Arrhythmia arrest

                                                                          ECG changes Peaked T waves (early change)

                                                                          Flattened P wave

                                                                          Prolonged PR interval (first-degree block)

                                                                          Widened QRS complex

                                                                          Sine wave formation

                                                                          Ventricular fibrillation

                                                                          Treatment

                                                                          Treatment of symptomatic hyperkalemia

                                                                          Potassium removal Kayexalate

                                                                          Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                          Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                          Dialysis

                                                                          Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                          Bicarbonate 1 vial intravenous

                                                                          Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                          HypokalemiaEtiology

                                                                          inadequate intake

                                                                          Dietary potassium-free intravenous fluids potassium-deficient

                                                                          total parenteral nutrition

                                                                          Excessive potassium excretion

                                                                          Hyperaldosteronism

                                                                          Medications

                                                                          Gastrointestinal losses

                                                                          Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                          Renal loss of potassium (gastric fluid either as vomiting or high

                                                                          nasogastric output)

                                                                          Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                          Potassium changes associated with alkalosis

                                                                          Potassium decrease by 03 meqL for every 01

                                                                          increase in PH above normal

                                                                          Magnesium Depletion

                                                                          (drug induced amphotericin amioglycosides cisplatin)

                                                                          Renal potassium wastage

                                                                          Hypokalemia

                                                                          Magnesium Depletion

                                                                          (drug induced amphotericin amioglycosides cisplatin)

                                                                          Renal potassium wastage

                                                                          Hypokalemia

                                                                          Clinical Manifestation of Abnormalities in potassium

                                                                          System hypokalemia

                                                                          Gastrointestinal Ileus constipation

                                                                          Neuromuscular Decreased reflexes fatigue weakness

                                                                          paralysis

                                                                          Cardiovascular Arrest

                                                                          ECG changes U-waves

                                                                          T-wave flattening

                                                                          ST-segment changes

                                                                          Arrhythmias

                                                                          Treatment

                                                                          Potassium

                                                                          Serum potassium level lt40 mEqL

                                                                          Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                          times 1 doses

                                                                          Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                          Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                          Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                          asymptomatic replace as per above protocol

                                                                          Electrolyte Replacement Therapy Protocol

                                                                          bull Oral repletion for mild and asymptomatic hypokalemia

                                                                          bull IV repletion for severe and symptomatic hypokalemia

                                                                          Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                          ( دندانها( ndash استخوانbull كلسيم نقش

                                                                          عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                          صاف 2 عضالت انقباض

                                                                          هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                          انعقاد 4

                                                                          یونیزه Calt45 meql هيپوكلسمي

                                                                          عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                          ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                          میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                          ( شود می پیوند شده

                                                                          هیپوکلسمی عالئم

                                                                          رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                          سایرعالئم

                                                                          قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                          درمان

                                                                          ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                          Cagt55meql هيپركلسمي

                                                                          هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                          عالئم

                                                                          bullGI

                                                                          bullCardiovascular bullRenal (polyuria)

                                                                          bullCNS

                                                                          قلبی عالئم

                                                                          bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                          QRS شدن )Q-Tوكوتاه

                                                                          درمان

                                                                          ایزوتونیک 1 نمکی محلول انفوزیون

                                                                          الزیکس2

                                                                          تونین 3 کلسی

                                                                          کورتون4

                                                                          دیالیز5

                                                                          Magnesium Abnormalities

                                                                          Normal dietary intake 20meq (240mg)

                                                                          Excretion in both the feces and urine

                                                                          Normal serum level 19-25 mgdL

                                                                          منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                          تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                          bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                          Hypermagnesemia

                                                                          Etiology

                                                                          1 Impaired renal function

                                                                          2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                          Clinical manifestation hypermanesemia

                                                                          System hypermanesemia

                                                                          Gastrointestinal Nauseavomiting

                                                                          Neuromuscular weakness lethargy Decreased

                                                                          reflexes

                                                                          Cardiovascular Hypotension arrest

                                                                          ECG changes Increased PR interval

                                                                          Widened QRS complex

                                                                          Elevated T waves

                                                                          Treatment

                                                                          1 Withhold exogenous sources of magnesium

                                                                          2 Correct volume deficit

                                                                          3 Correct acidosis if present

                                                                          4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                          5 Dialysis (if elevated levels or symptoms persist)

                                                                          عالئم

                                                                          bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                          meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                          meqL

                                                                          Hypomagnesemia

                                                                          Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                          homeostasis

                                                                          Etiology

                                                                          1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                          inadequate supplementation of magnesium)

                                                                          2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                          3 GI losses (diarrhea)

                                                                          4 Malabsorption

                                                                          5 Acute pancreatitis

                                                                          6 Diabetic ketoacidosis

                                                                          7 Primary aldosteronism

                                                                          Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                          1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                          2 Delirium and seizures in severe deficiency

                                                                          3 ECG changes Prolonged QT and PR interval

                                                                          ST-segment depression

                                                                          Flattening or inversion of P waves

                                                                          Torsades de pointes

                                                                          Arrhythmia

                                                                          Treatment

                                                                          1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                          2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                          Message for Today

                                                                          ICF

                                                                          Interstitial

                                                                          Pla

                                                                          sma

                                                                          5 Dex

                                                                          bull Do not reccussitate sick patients with any Dextrose solution

                                                                          • Fluid and Electrolyte Management of the Surgical Patient
                                                                          • Slide 2
                                                                          • Slide 3
                                                                          • Slide 4
                                                                          • Total Body Water
                                                                          • Body Fluid Compartments
                                                                          • Total body water (TBW)
                                                                          • Body compartment fluid
                                                                          • Example men with 70kg
                                                                          • Fluid compartments
                                                                          • Slide 11
                                                                          • Slide 12
                                                                          • Slide 13
                                                                          • Slide 14
                                                                          • Slide 15
                                                                          • Colloid osmotic pressure
                                                                          • Slide 17
                                                                          • Slide 18
                                                                          • Slide 19
                                                                          • Cell Membrane
                                                                          • Slide 21
                                                                          • Slide 22
                                                                          • Slide 23
                                                                          • Slide 24
                                                                          • Slide 25
                                                                          • Composition of Fluid Compartments
                                                                          • Composition of Body Fluids
                                                                          • عوامل موثر روی تغییرات آب والکترولیت
                                                                          • Reasons for fluid therapy
                                                                          • ارزیابی حجم مایع داخل عروقی
                                                                          • محلولهای وریدی
                                                                          • Fluids
                                                                          • Slide 33
                                                                          • Slide 34
                                                                          • Slide 35
                                                                          • Crystalloids
                                                                          • Colloid Solutions
                                                                          • رینگر لاکتات
                                                                          • 09Nacl
                                                                          • Postoperative (maintenance)
                                                                          • Slide 41
                                                                          • Preexisting fluid deficits
                                                                          • Maintenance requirements
                                                                          • Surgical fluid losses
                                                                          • Third space loss
                                                                          • Crystalloid solution
                                                                          • Colloids
                                                                          • Complications
                                                                          • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                          • Colloid versus crystalloid solutions
                                                                          • Transfusion consideration
                                                                          • اختلال در حجم مایعات بدن
                                                                          • Fluid volume deficit (FVD)
                                                                          • DEHYDRATION
                                                                          • علل کاهش حجم خارج سلولی
                                                                          • Signs of Hypovolemia
                                                                          • Clinical Diagnosis of Hypovolemia
                                                                          • Signs of Hypervolemia
                                                                          • Management of Hypervolemia
                                                                          • Fluid Management
                                                                          • Electrolyte physiology
                                                                          • Sodium physiology
                                                                          • Osmotic Pressure
                                                                          • Concentration
                                                                          • Hypernatremia
                                                                          • - Hypernatremia
                                                                          • Slide 67
                                                                          • Slide 68
                                                                          • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                          • Treatment
                                                                          • Water deficit (L)= times TBW
                                                                          • The rate of fluid administration
                                                                          • Hyponatremia Nalt135mEqL
                                                                          • Slide 74
                                                                          • Sodium depletion
                                                                          • Sodium dilution
                                                                          • Sign and symptoms
                                                                          • Slide 78
                                                                          • Treatment
                                                                          • Slide 80
                                                                          • Slide 81
                                                                          • Dose
                                                                          • Potassium abnormalities
                                                                          • Hyperkalemia
                                                                          • Clinical manifestation of hyperkalemia
                                                                          • Slide 86
                                                                          • Slide 87
                                                                          • Hypokalemia
                                                                          • Potassium changes associated with alkalosis
                                                                          • Slide 90
                                                                          • Clinical Manifestation of Abnormalities in potassium
                                                                          • Slide 92
                                                                          • Calcium
                                                                          • هيپوكلسمي یونیزه Calt45 meql
                                                                          • علائم هیپوکلسمی
                                                                          • Slide 96
                                                                          • Slide 97
                                                                          • Slide 98
                                                                          • Slide 99
                                                                          • سایرعلائم
                                                                          • درمان
                                                                          • هيپركلسمي Cagt55meql
                                                                          • علائم
                                                                          • علائم قلبی
                                                                          • Slide 105
                                                                          • Magnesium Abnormalities
                                                                          • منیزیوم
                                                                          • Hypermagnesemia
                                                                          • Clinical manifestation hypermanesemia
                                                                          • Slide 110
                                                                          • Slide 111
                                                                          • Hypomagnesemia
                                                                          • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                          • Slide 114
                                                                          • Message for Today
                                                                          • Slide 116

                                                                            09Nacl

                                                                            bull Na=154

                                                                            bull CL= 154

                                                                            کاهش bull جبران جهت مایع حضور ECFاین درال ایده متابولیک آلکالوز و وهیپوکلرمی هیپوناترمی

                                                                            PH=56است

                                                                            Postoperative (maintenance)

                                                                            045Nacl +5 dextrose +KCL

                                                                            Perioperative management of fluid balance include

                                                                            1 Preoperative evaluation

                                                                            2 Intraoperative maintenance

                                                                            3 Replacement of fluid losses

                                                                            Preexisting fluid deficits

                                                                            bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                                                            bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                                                            Maintenance requirements

                                                                            bull Up to 10 kg = 4cckghr

                                                                            bull 11-20kg = add 2cckghr

                                                                            bull 21kg and above = add 1cckghr

                                                                            bull Insensible losses = 2cckghr

                                                                            Surgical fluid losses

                                                                            Blood loss (measurement)

                                                                            1 Suction container

                                                                            2 Surgical sponge

                                                                            3 Hct and tachycardia not specific

                                                                            4 ABG and UO if hypoperfusion occur

                                                                            5 Blood loss=31 with crystalloid

                                                                            Other losses (third space loss)

                                                                            Third space loss

                                                                            1 Minimal (herniorrapy) =2-4cckghr

                                                                            2 Moderate (cholecystectomy)=4-6cckghr

                                                                            3 Severe (bowel resection) = 6-8cckghr

                                                                            Crystalloid solution

                                                                            1 The main solutions is either glucose or saline

                                                                            2 Hypotonic or isotonic or hypertonic

                                                                            3 Safe nontoxic reaction free inexpensive

                                                                            4 Complication is edema if large volumes are needed

                                                                            5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                                            Colloids

                                                                            1 Albumin

                                                                            2 Hydroxyethyl starch

                                                                            3 Dextran

                                                                            Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                                            factor )These colloid is best avoided in patients with

                                                                            coagulopaty

                                                                            The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                                            1000cc

                                                                            500cc

                                                                            500cc

                                                                            500cc

                                                                            200

                                                                            600

                                                                            1000

                                                                            Lactated Ringers

                                                                            5 Albumin

                                                                            6 Hetastarch

                                                                            Whole blood

                                                                            Blood volumeInfusion volume

                                                                            Colloid versus crystalloid solutions

                                                                            Transfusion consideration

                                                                            bull HB lt7 mg dl increase CO

                                                                            bull Ideal Hb is 7-8 mgdl

                                                                            bull In IHD patients or pulmonary disease gt 10 mgdl

                                                                            بدن مایعات حجم در اختالل

                                                                            1 Fluid volume deficit

                                                                            2 Fluid volume excess

                                                                            Fluid volume deficit(FVD)

                                                                            ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                            کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                            ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                            باشد آن با همراه دیگری اختالل مگر

                                                                            DEHYDRATION

                                                                            سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                            سلولی خارج حجم کاهش علل

                                                                            1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                            2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                            کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                            Signs of HypovolemiaSigns of Hypovolemia

                                                                            bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                            Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                            bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                            Signs of HypervolemiaSigns of Hypervolemia

                                                                            bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                            Especially when hypo-albuminemia

                                                                            Management of Management of HypervolemiaHypervolemia

                                                                            bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                            Fluid ManagementFluid Management

                                                                            bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                            Electrolyte physiology

                                                                            Sodium physiology

                                                                            Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                            Normal amount 135-145 meql

                                                                            Osmotic Pressure

                                                                            Calculated serum osmolality =

                                                                            2 sodium+ glucose18 + BUN 28

                                                                            Osmolality = 290 mosm

                                                                            Concentration

                                                                            1Serum sodium concentration2Serum osmolarity

                                                                            bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                            drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                            DW5)

                                                                            Hypernatremia

                                                                            Serum Nagt145mEqL

                                                                            - Hypernatremia

                                                                            Loss of Free Water

                                                                            Gain of sodium in excess of water

                                                                            Hypernatremia

                                                                            -Hypernatremia Hypo volemic

                                                                            Hyper volemic

                                                                            Normo volemic

                                                                            Hypernatremia

                                                                            Volume Status

                                                                            Normal

                                                                            Nonrenal water loss

                                                                            Skin

                                                                            Gastrointestinal

                                                                            Renal water loss

                                                                            Renal disease

                                                                            Diuretics

                                                                            Diabetes insipidus

                                                                            High

                                                                            Iatrogenic sodium administration

                                                                            Mineralocorticoid excess

                                                                            Aldosteronism

                                                                            Cushingrsquos disease

                                                                            Congenital adrenal

                                                                            hyperplasia

                                                                            Low

                                                                            Nonrenal water loss

                                                                            Skin

                                                                            Gastrointestinal losses

                                                                            Renal water losses

                                                                            Renal (tubular) Diuretics

                                                                            Osmotic diuretics

                                                                            Diabetes insipidus

                                                                            Adrenal failure

                                                                            Asymptomatic

                                                                            Hypernatremia Symptomatic (Nagt160 meqL)

                                                                            Clinical Manifestations of Abnormalities in Serum Sodium

                                                                            Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                            Body system hypernatremia

                                                                            Treatment

                                                                            Normal saline in hypovolemic patients

                                                                            Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                            saline or entral water)

                                                                            Water deficit (L)= times TBW

                                                                            The formula used to estimate the amount of water required to correct hypernatremia

                                                                            Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                            Serum sodium-140

                                                                            140

                                                                            The rate of fluid administration

                                                                            1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                            2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                            Hyponatremia Nalt135mEqL

                                                                            Causes

                                                                            1 Sodium depletion

                                                                            2 Sodium dilution

                                                                            bull Incidence = 45

                                                                            bull After surgery=1

                                                                            bull Mortality = 2 times normal

                                                                            Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                            volume deficit

                                                                            Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                            Sign and symptoms

                                                                            bull CNS symptom when Nalt123 meql

                                                                            bull Cardiac symptom when Nalt100 meql

                                                                            For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                            Body System Hyponatremia

                                                                            central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                            reflexes seizures coma increased intracranial pressure

                                                                            Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                            Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                            Cardiovascular Hypertension and bradycardia if significant increases in

                                                                            intracranial pressure

                                                                            Tissue Lacrimation salivation

                                                                            Renal Oliguria

                                                                            Clinical Manifestations of Abnormalities in Serum Sodium

                                                                            Treatment

                                                                            1=Depend on ECF

                                                                            2=CNS sign

                                                                            Treatment

                                                                            1 Asymptomatic increase the sodium level by no more than

                                                                            05-1 meqLh to a maximum increase of 12 meqL per day

                                                                            2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                            more than 1meqL per hour until the serum Na level reaches 130

                                                                            meqL or neurologic symptoms are improved

                                                                            Rapid correction of hyponatremia

                                                                            Pontine myelinolysis

                                                                            Seizures weaknessparesis akinetic

                                                                            movements unresponsiveness

                                                                            Permanent brain damage

                                                                            Death

                                                                            Dose

                                                                            Na deficit meq =(140- Na meql) TBW

                                                                            باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                            شود اصالح آهسته سپس

                                                                            Potassium abnormalities

                                                                            bull The average dietary intake of potassium 50-100meqd

                                                                            bull The average renal excretion of potassium 10-700 meqd

                                                                            - 2 of the total body potassium in ECF (45meqL)

                                                                            - Factors that influence serum potassium

                                                                            1 Surgical stress

                                                                            2 Injury

                                                                            3 Acidosis

                                                                            4 Tissue catabolism

                                                                            Hyperkalemia

                                                                            The normal range of serum potassium 35-5 meqL

                                                                            Etiology of Hyperkalemia

                                                                            Increased intake Potassium supplementation

                                                                            Blood transfusions

                                                                            Endogenous loaddestruction

                                                                            hemolysis rhabdomyolysis

                                                                            cruch injury gastrointestinal hemorrhage

                                                                            Increased release Acidosis

                                                                            Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                            Renal insufficiencyfailure

                                                                            Clinical manifestation of hyperkalemia

                                                                            System hyperkalemia

                                                                            Gastrointestinal Nauseavomiting colic diarrhea

                                                                            Neuromuscular weakness paralysis respiratory failure

                                                                            Cardiovascular Arrhythmia arrest

                                                                            ECG changes Peaked T waves (early change)

                                                                            Flattened P wave

                                                                            Prolonged PR interval (first-degree block)

                                                                            Widened QRS complex

                                                                            Sine wave formation

                                                                            Ventricular fibrillation

                                                                            Treatment

                                                                            Treatment of symptomatic hyperkalemia

                                                                            Potassium removal Kayexalate

                                                                            Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                            Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                            Dialysis

                                                                            Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                            Bicarbonate 1 vial intravenous

                                                                            Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                            HypokalemiaEtiology

                                                                            inadequate intake

                                                                            Dietary potassium-free intravenous fluids potassium-deficient

                                                                            total parenteral nutrition

                                                                            Excessive potassium excretion

                                                                            Hyperaldosteronism

                                                                            Medications

                                                                            Gastrointestinal losses

                                                                            Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                            Renal loss of potassium (gastric fluid either as vomiting or high

                                                                            nasogastric output)

                                                                            Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                            Potassium changes associated with alkalosis

                                                                            Potassium decrease by 03 meqL for every 01

                                                                            increase in PH above normal

                                                                            Magnesium Depletion

                                                                            (drug induced amphotericin amioglycosides cisplatin)

                                                                            Renal potassium wastage

                                                                            Hypokalemia

                                                                            Magnesium Depletion

                                                                            (drug induced amphotericin amioglycosides cisplatin)

                                                                            Renal potassium wastage

                                                                            Hypokalemia

                                                                            Clinical Manifestation of Abnormalities in potassium

                                                                            System hypokalemia

                                                                            Gastrointestinal Ileus constipation

                                                                            Neuromuscular Decreased reflexes fatigue weakness

                                                                            paralysis

                                                                            Cardiovascular Arrest

                                                                            ECG changes U-waves

                                                                            T-wave flattening

                                                                            ST-segment changes

                                                                            Arrhythmias

                                                                            Treatment

                                                                            Potassium

                                                                            Serum potassium level lt40 mEqL

                                                                            Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                            times 1 doses

                                                                            Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                            Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                            Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                            asymptomatic replace as per above protocol

                                                                            Electrolyte Replacement Therapy Protocol

                                                                            bull Oral repletion for mild and asymptomatic hypokalemia

                                                                            bull IV repletion for severe and symptomatic hypokalemia

                                                                            Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                            ( دندانها( ndash استخوانbull كلسيم نقش

                                                                            عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                            صاف 2 عضالت انقباض

                                                                            هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                            انعقاد 4

                                                                            یونیزه Calt45 meql هيپوكلسمي

                                                                            عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                            ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                            میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                            ( شود می پیوند شده

                                                                            هیپوکلسمی عالئم

                                                                            رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                            سایرعالئم

                                                                            قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                            درمان

                                                                            ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                            Cagt55meql هيپركلسمي

                                                                            هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                            عالئم

                                                                            bullGI

                                                                            bullCardiovascular bullRenal (polyuria)

                                                                            bullCNS

                                                                            قلبی عالئم

                                                                            bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                            QRS شدن )Q-Tوكوتاه

                                                                            درمان

                                                                            ایزوتونیک 1 نمکی محلول انفوزیون

                                                                            الزیکس2

                                                                            تونین 3 کلسی

                                                                            کورتون4

                                                                            دیالیز5

                                                                            Magnesium Abnormalities

                                                                            Normal dietary intake 20meq (240mg)

                                                                            Excretion in both the feces and urine

                                                                            Normal serum level 19-25 mgdL

                                                                            منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                            تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                            bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                            Hypermagnesemia

                                                                            Etiology

                                                                            1 Impaired renal function

                                                                            2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                            Clinical manifestation hypermanesemia

                                                                            System hypermanesemia

                                                                            Gastrointestinal Nauseavomiting

                                                                            Neuromuscular weakness lethargy Decreased

                                                                            reflexes

                                                                            Cardiovascular Hypotension arrest

                                                                            ECG changes Increased PR interval

                                                                            Widened QRS complex

                                                                            Elevated T waves

                                                                            Treatment

                                                                            1 Withhold exogenous sources of magnesium

                                                                            2 Correct volume deficit

                                                                            3 Correct acidosis if present

                                                                            4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                            5 Dialysis (if elevated levels or symptoms persist)

                                                                            عالئم

                                                                            bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                            meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                            meqL

                                                                            Hypomagnesemia

                                                                            Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                            homeostasis

                                                                            Etiology

                                                                            1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                            inadequate supplementation of magnesium)

                                                                            2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                            3 GI losses (diarrhea)

                                                                            4 Malabsorption

                                                                            5 Acute pancreatitis

                                                                            6 Diabetic ketoacidosis

                                                                            7 Primary aldosteronism

                                                                            Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                            1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                            2 Delirium and seizures in severe deficiency

                                                                            3 ECG changes Prolonged QT and PR interval

                                                                            ST-segment depression

                                                                            Flattening or inversion of P waves

                                                                            Torsades de pointes

                                                                            Arrhythmia

                                                                            Treatment

                                                                            1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                            2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                            Message for Today

                                                                            ICF

                                                                            Interstitial

                                                                            Pla

                                                                            sma

                                                                            5 Dex

                                                                            bull Do not reccussitate sick patients with any Dextrose solution

                                                                            • Fluid and Electrolyte Management of the Surgical Patient
                                                                            • Slide 2
                                                                            • Slide 3
                                                                            • Slide 4
                                                                            • Total Body Water
                                                                            • Body Fluid Compartments
                                                                            • Total body water (TBW)
                                                                            • Body compartment fluid
                                                                            • Example men with 70kg
                                                                            • Fluid compartments
                                                                            • Slide 11
                                                                            • Slide 12
                                                                            • Slide 13
                                                                            • Slide 14
                                                                            • Slide 15
                                                                            • Colloid osmotic pressure
                                                                            • Slide 17
                                                                            • Slide 18
                                                                            • Slide 19
                                                                            • Cell Membrane
                                                                            • Slide 21
                                                                            • Slide 22
                                                                            • Slide 23
                                                                            • Slide 24
                                                                            • Slide 25
                                                                            • Composition of Fluid Compartments
                                                                            • Composition of Body Fluids
                                                                            • عوامل موثر روی تغییرات آب والکترولیت
                                                                            • Reasons for fluid therapy
                                                                            • ارزیابی حجم مایع داخل عروقی
                                                                            • محلولهای وریدی
                                                                            • Fluids
                                                                            • Slide 33
                                                                            • Slide 34
                                                                            • Slide 35
                                                                            • Crystalloids
                                                                            • Colloid Solutions
                                                                            • رینگر لاکتات
                                                                            • 09Nacl
                                                                            • Postoperative (maintenance)
                                                                            • Slide 41
                                                                            • Preexisting fluid deficits
                                                                            • Maintenance requirements
                                                                            • Surgical fluid losses
                                                                            • Third space loss
                                                                            • Crystalloid solution
                                                                            • Colloids
                                                                            • Complications
                                                                            • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                            • Colloid versus crystalloid solutions
                                                                            • Transfusion consideration
                                                                            • اختلال در حجم مایعات بدن
                                                                            • Fluid volume deficit (FVD)
                                                                            • DEHYDRATION
                                                                            • علل کاهش حجم خارج سلولی
                                                                            • Signs of Hypovolemia
                                                                            • Clinical Diagnosis of Hypovolemia
                                                                            • Signs of Hypervolemia
                                                                            • Management of Hypervolemia
                                                                            • Fluid Management
                                                                            • Electrolyte physiology
                                                                            • Sodium physiology
                                                                            • Osmotic Pressure
                                                                            • Concentration
                                                                            • Hypernatremia
                                                                            • - Hypernatremia
                                                                            • Slide 67
                                                                            • Slide 68
                                                                            • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                            • Treatment
                                                                            • Water deficit (L)= times TBW
                                                                            • The rate of fluid administration
                                                                            • Hyponatremia Nalt135mEqL
                                                                            • Slide 74
                                                                            • Sodium depletion
                                                                            • Sodium dilution
                                                                            • Sign and symptoms
                                                                            • Slide 78
                                                                            • Treatment
                                                                            • Slide 80
                                                                            • Slide 81
                                                                            • Dose
                                                                            • Potassium abnormalities
                                                                            • Hyperkalemia
                                                                            • Clinical manifestation of hyperkalemia
                                                                            • Slide 86
                                                                            • Slide 87
                                                                            • Hypokalemia
                                                                            • Potassium changes associated with alkalosis
                                                                            • Slide 90
                                                                            • Clinical Manifestation of Abnormalities in potassium
                                                                            • Slide 92
                                                                            • Calcium
                                                                            • هيپوكلسمي یونیزه Calt45 meql
                                                                            • علائم هیپوکلسمی
                                                                            • Slide 96
                                                                            • Slide 97
                                                                            • Slide 98
                                                                            • Slide 99
                                                                            • سایرعلائم
                                                                            • درمان
                                                                            • هيپركلسمي Cagt55meql
                                                                            • علائم
                                                                            • علائم قلبی
                                                                            • Slide 105
                                                                            • Magnesium Abnormalities
                                                                            • منیزیوم
                                                                            • Hypermagnesemia
                                                                            • Clinical manifestation hypermanesemia
                                                                            • Slide 110
                                                                            • Slide 111
                                                                            • Hypomagnesemia
                                                                            • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                            • Slide 114
                                                                            • Message for Today
                                                                            • Slide 116

                                                                              Postoperative (maintenance)

                                                                              045Nacl +5 dextrose +KCL

                                                                              Perioperative management of fluid balance include

                                                                              1 Preoperative evaluation

                                                                              2 Intraoperative maintenance

                                                                              3 Replacement of fluid losses

                                                                              Preexisting fluid deficits

                                                                              bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                                                              bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                                                              Maintenance requirements

                                                                              bull Up to 10 kg = 4cckghr

                                                                              bull 11-20kg = add 2cckghr

                                                                              bull 21kg and above = add 1cckghr

                                                                              bull Insensible losses = 2cckghr

                                                                              Surgical fluid losses

                                                                              Blood loss (measurement)

                                                                              1 Suction container

                                                                              2 Surgical sponge

                                                                              3 Hct and tachycardia not specific

                                                                              4 ABG and UO if hypoperfusion occur

                                                                              5 Blood loss=31 with crystalloid

                                                                              Other losses (third space loss)

                                                                              Third space loss

                                                                              1 Minimal (herniorrapy) =2-4cckghr

                                                                              2 Moderate (cholecystectomy)=4-6cckghr

                                                                              3 Severe (bowel resection) = 6-8cckghr

                                                                              Crystalloid solution

                                                                              1 The main solutions is either glucose or saline

                                                                              2 Hypotonic or isotonic or hypertonic

                                                                              3 Safe nontoxic reaction free inexpensive

                                                                              4 Complication is edema if large volumes are needed

                                                                              5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                                              Colloids

                                                                              1 Albumin

                                                                              2 Hydroxyethyl starch

                                                                              3 Dextran

                                                                              Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                                              factor )These colloid is best avoided in patients with

                                                                              coagulopaty

                                                                              The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                                              1000cc

                                                                              500cc

                                                                              500cc

                                                                              500cc

                                                                              200

                                                                              600

                                                                              1000

                                                                              Lactated Ringers

                                                                              5 Albumin

                                                                              6 Hetastarch

                                                                              Whole blood

                                                                              Blood volumeInfusion volume

                                                                              Colloid versus crystalloid solutions

                                                                              Transfusion consideration

                                                                              bull HB lt7 mg dl increase CO

                                                                              bull Ideal Hb is 7-8 mgdl

                                                                              bull In IHD patients or pulmonary disease gt 10 mgdl

                                                                              بدن مایعات حجم در اختالل

                                                                              1 Fluid volume deficit

                                                                              2 Fluid volume excess

                                                                              Fluid volume deficit(FVD)

                                                                              ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                              کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                              ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                              باشد آن با همراه دیگری اختالل مگر

                                                                              DEHYDRATION

                                                                              سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                              سلولی خارج حجم کاهش علل

                                                                              1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                              2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                              کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                              Signs of HypovolemiaSigns of Hypovolemia

                                                                              bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                              Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                              bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                              Signs of HypervolemiaSigns of Hypervolemia

                                                                              bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                              Especially when hypo-albuminemia

                                                                              Management of Management of HypervolemiaHypervolemia

                                                                              bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                              Fluid ManagementFluid Management

                                                                              bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                              Electrolyte physiology

                                                                              Sodium physiology

                                                                              Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                              Normal amount 135-145 meql

                                                                              Osmotic Pressure

                                                                              Calculated serum osmolality =

                                                                              2 sodium+ glucose18 + BUN 28

                                                                              Osmolality = 290 mosm

                                                                              Concentration

                                                                              1Serum sodium concentration2Serum osmolarity

                                                                              bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                              drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                              DW5)

                                                                              Hypernatremia

                                                                              Serum Nagt145mEqL

                                                                              - Hypernatremia

                                                                              Loss of Free Water

                                                                              Gain of sodium in excess of water

                                                                              Hypernatremia

                                                                              -Hypernatremia Hypo volemic

                                                                              Hyper volemic

                                                                              Normo volemic

                                                                              Hypernatremia

                                                                              Volume Status

                                                                              Normal

                                                                              Nonrenal water loss

                                                                              Skin

                                                                              Gastrointestinal

                                                                              Renal water loss

                                                                              Renal disease

                                                                              Diuretics

                                                                              Diabetes insipidus

                                                                              High

                                                                              Iatrogenic sodium administration

                                                                              Mineralocorticoid excess

                                                                              Aldosteronism

                                                                              Cushingrsquos disease

                                                                              Congenital adrenal

                                                                              hyperplasia

                                                                              Low

                                                                              Nonrenal water loss

                                                                              Skin

                                                                              Gastrointestinal losses

                                                                              Renal water losses

                                                                              Renal (tubular) Diuretics

                                                                              Osmotic diuretics

                                                                              Diabetes insipidus

                                                                              Adrenal failure

                                                                              Asymptomatic

                                                                              Hypernatremia Symptomatic (Nagt160 meqL)

                                                                              Clinical Manifestations of Abnormalities in Serum Sodium

                                                                              Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                              Body system hypernatremia

                                                                              Treatment

                                                                              Normal saline in hypovolemic patients

                                                                              Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                              saline or entral water)

                                                                              Water deficit (L)= times TBW

                                                                              The formula used to estimate the amount of water required to correct hypernatremia

                                                                              Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                              Serum sodium-140

                                                                              140

                                                                              The rate of fluid administration

                                                                              1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                              2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                              Hyponatremia Nalt135mEqL

                                                                              Causes

                                                                              1 Sodium depletion

                                                                              2 Sodium dilution

                                                                              bull Incidence = 45

                                                                              bull After surgery=1

                                                                              bull Mortality = 2 times normal

                                                                              Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                              volume deficit

                                                                              Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                              Sign and symptoms

                                                                              bull CNS symptom when Nalt123 meql

                                                                              bull Cardiac symptom when Nalt100 meql

                                                                              For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                              Body System Hyponatremia

                                                                              central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                              reflexes seizures coma increased intracranial pressure

                                                                              Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                              Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                              Cardiovascular Hypertension and bradycardia if significant increases in

                                                                              intracranial pressure

                                                                              Tissue Lacrimation salivation

                                                                              Renal Oliguria

                                                                              Clinical Manifestations of Abnormalities in Serum Sodium

                                                                              Treatment

                                                                              1=Depend on ECF

                                                                              2=CNS sign

                                                                              Treatment

                                                                              1 Asymptomatic increase the sodium level by no more than

                                                                              05-1 meqLh to a maximum increase of 12 meqL per day

                                                                              2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                              more than 1meqL per hour until the serum Na level reaches 130

                                                                              meqL or neurologic symptoms are improved

                                                                              Rapid correction of hyponatremia

                                                                              Pontine myelinolysis

                                                                              Seizures weaknessparesis akinetic

                                                                              movements unresponsiveness

                                                                              Permanent brain damage

                                                                              Death

                                                                              Dose

                                                                              Na deficit meq =(140- Na meql) TBW

                                                                              باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                              شود اصالح آهسته سپس

                                                                              Potassium abnormalities

                                                                              bull The average dietary intake of potassium 50-100meqd

                                                                              bull The average renal excretion of potassium 10-700 meqd

                                                                              - 2 of the total body potassium in ECF (45meqL)

                                                                              - Factors that influence serum potassium

                                                                              1 Surgical stress

                                                                              2 Injury

                                                                              3 Acidosis

                                                                              4 Tissue catabolism

                                                                              Hyperkalemia

                                                                              The normal range of serum potassium 35-5 meqL

                                                                              Etiology of Hyperkalemia

                                                                              Increased intake Potassium supplementation

                                                                              Blood transfusions

                                                                              Endogenous loaddestruction

                                                                              hemolysis rhabdomyolysis

                                                                              cruch injury gastrointestinal hemorrhage

                                                                              Increased release Acidosis

                                                                              Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                              Renal insufficiencyfailure

                                                                              Clinical manifestation of hyperkalemia

                                                                              System hyperkalemia

                                                                              Gastrointestinal Nauseavomiting colic diarrhea

                                                                              Neuromuscular weakness paralysis respiratory failure

                                                                              Cardiovascular Arrhythmia arrest

                                                                              ECG changes Peaked T waves (early change)

                                                                              Flattened P wave

                                                                              Prolonged PR interval (first-degree block)

                                                                              Widened QRS complex

                                                                              Sine wave formation

                                                                              Ventricular fibrillation

                                                                              Treatment

                                                                              Treatment of symptomatic hyperkalemia

                                                                              Potassium removal Kayexalate

                                                                              Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                              Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                              Dialysis

                                                                              Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                              Bicarbonate 1 vial intravenous

                                                                              Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                              HypokalemiaEtiology

                                                                              inadequate intake

                                                                              Dietary potassium-free intravenous fluids potassium-deficient

                                                                              total parenteral nutrition

                                                                              Excessive potassium excretion

                                                                              Hyperaldosteronism

                                                                              Medications

                                                                              Gastrointestinal losses

                                                                              Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                              Renal loss of potassium (gastric fluid either as vomiting or high

                                                                              nasogastric output)

                                                                              Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                              Potassium changes associated with alkalosis

                                                                              Potassium decrease by 03 meqL for every 01

                                                                              increase in PH above normal

                                                                              Magnesium Depletion

                                                                              (drug induced amphotericin amioglycosides cisplatin)

                                                                              Renal potassium wastage

                                                                              Hypokalemia

                                                                              Magnesium Depletion

                                                                              (drug induced amphotericin amioglycosides cisplatin)

                                                                              Renal potassium wastage

                                                                              Hypokalemia

                                                                              Clinical Manifestation of Abnormalities in potassium

                                                                              System hypokalemia

                                                                              Gastrointestinal Ileus constipation

                                                                              Neuromuscular Decreased reflexes fatigue weakness

                                                                              paralysis

                                                                              Cardiovascular Arrest

                                                                              ECG changes U-waves

                                                                              T-wave flattening

                                                                              ST-segment changes

                                                                              Arrhythmias

                                                                              Treatment

                                                                              Potassium

                                                                              Serum potassium level lt40 mEqL

                                                                              Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                              times 1 doses

                                                                              Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                              Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                              Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                              asymptomatic replace as per above protocol

                                                                              Electrolyte Replacement Therapy Protocol

                                                                              bull Oral repletion for mild and asymptomatic hypokalemia

                                                                              bull IV repletion for severe and symptomatic hypokalemia

                                                                              Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                              ( دندانها( ndash استخوانbull كلسيم نقش

                                                                              عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                              صاف 2 عضالت انقباض

                                                                              هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                              انعقاد 4

                                                                              یونیزه Calt45 meql هيپوكلسمي

                                                                              عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                              ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                              میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                              ( شود می پیوند شده

                                                                              هیپوکلسمی عالئم

                                                                              رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                              سایرعالئم

                                                                              قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                              درمان

                                                                              ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                              Cagt55meql هيپركلسمي

                                                                              هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                              عالئم

                                                                              bullGI

                                                                              bullCardiovascular bullRenal (polyuria)

                                                                              bullCNS

                                                                              قلبی عالئم

                                                                              bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                              QRS شدن )Q-Tوكوتاه

                                                                              درمان

                                                                              ایزوتونیک 1 نمکی محلول انفوزیون

                                                                              الزیکس2

                                                                              تونین 3 کلسی

                                                                              کورتون4

                                                                              دیالیز5

                                                                              Magnesium Abnormalities

                                                                              Normal dietary intake 20meq (240mg)

                                                                              Excretion in both the feces and urine

                                                                              Normal serum level 19-25 mgdL

                                                                              منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                              تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                              bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                              Hypermagnesemia

                                                                              Etiology

                                                                              1 Impaired renal function

                                                                              2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                              Clinical manifestation hypermanesemia

                                                                              System hypermanesemia

                                                                              Gastrointestinal Nauseavomiting

                                                                              Neuromuscular weakness lethargy Decreased

                                                                              reflexes

                                                                              Cardiovascular Hypotension arrest

                                                                              ECG changes Increased PR interval

                                                                              Widened QRS complex

                                                                              Elevated T waves

                                                                              Treatment

                                                                              1 Withhold exogenous sources of magnesium

                                                                              2 Correct volume deficit

                                                                              3 Correct acidosis if present

                                                                              4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                              5 Dialysis (if elevated levels or symptoms persist)

                                                                              عالئم

                                                                              bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                              meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                              meqL

                                                                              Hypomagnesemia

                                                                              Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                              homeostasis

                                                                              Etiology

                                                                              1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                              inadequate supplementation of magnesium)

                                                                              2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                              3 GI losses (diarrhea)

                                                                              4 Malabsorption

                                                                              5 Acute pancreatitis

                                                                              6 Diabetic ketoacidosis

                                                                              7 Primary aldosteronism

                                                                              Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                              1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                              2 Delirium and seizures in severe deficiency

                                                                              3 ECG changes Prolonged QT and PR interval

                                                                              ST-segment depression

                                                                              Flattening or inversion of P waves

                                                                              Torsades de pointes

                                                                              Arrhythmia

                                                                              Treatment

                                                                              1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                              2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                              Message for Today

                                                                              ICF

                                                                              Interstitial

                                                                              Pla

                                                                              sma

                                                                              5 Dex

                                                                              bull Do not reccussitate sick patients with any Dextrose solution

                                                                              • Fluid and Electrolyte Management of the Surgical Patient
                                                                              • Slide 2
                                                                              • Slide 3
                                                                              • Slide 4
                                                                              • Total Body Water
                                                                              • Body Fluid Compartments
                                                                              • Total body water (TBW)
                                                                              • Body compartment fluid
                                                                              • Example men with 70kg
                                                                              • Fluid compartments
                                                                              • Slide 11
                                                                              • Slide 12
                                                                              • Slide 13
                                                                              • Slide 14
                                                                              • Slide 15
                                                                              • Colloid osmotic pressure
                                                                              • Slide 17
                                                                              • Slide 18
                                                                              • Slide 19
                                                                              • Cell Membrane
                                                                              • Slide 21
                                                                              • Slide 22
                                                                              • Slide 23
                                                                              • Slide 24
                                                                              • Slide 25
                                                                              • Composition of Fluid Compartments
                                                                              • Composition of Body Fluids
                                                                              • عوامل موثر روی تغییرات آب والکترولیت
                                                                              • Reasons for fluid therapy
                                                                              • ارزیابی حجم مایع داخل عروقی
                                                                              • محلولهای وریدی
                                                                              • Fluids
                                                                              • Slide 33
                                                                              • Slide 34
                                                                              • Slide 35
                                                                              • Crystalloids
                                                                              • Colloid Solutions
                                                                              • رینگر لاکتات
                                                                              • 09Nacl
                                                                              • Postoperative (maintenance)
                                                                              • Slide 41
                                                                              • Preexisting fluid deficits
                                                                              • Maintenance requirements
                                                                              • Surgical fluid losses
                                                                              • Third space loss
                                                                              • Crystalloid solution
                                                                              • Colloids
                                                                              • Complications
                                                                              • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                              • Colloid versus crystalloid solutions
                                                                              • Transfusion consideration
                                                                              • اختلال در حجم مایعات بدن
                                                                              • Fluid volume deficit (FVD)
                                                                              • DEHYDRATION
                                                                              • علل کاهش حجم خارج سلولی
                                                                              • Signs of Hypovolemia
                                                                              • Clinical Diagnosis of Hypovolemia
                                                                              • Signs of Hypervolemia
                                                                              • Management of Hypervolemia
                                                                              • Fluid Management
                                                                              • Electrolyte physiology
                                                                              • Sodium physiology
                                                                              • Osmotic Pressure
                                                                              • Concentration
                                                                              • Hypernatremia
                                                                              • - Hypernatremia
                                                                              • Slide 67
                                                                              • Slide 68
                                                                              • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                              • Treatment
                                                                              • Water deficit (L)= times TBW
                                                                              • The rate of fluid administration
                                                                              • Hyponatremia Nalt135mEqL
                                                                              • Slide 74
                                                                              • Sodium depletion
                                                                              • Sodium dilution
                                                                              • Sign and symptoms
                                                                              • Slide 78
                                                                              • Treatment
                                                                              • Slide 80
                                                                              • Slide 81
                                                                              • Dose
                                                                              • Potassium abnormalities
                                                                              • Hyperkalemia
                                                                              • Clinical manifestation of hyperkalemia
                                                                              • Slide 86
                                                                              • Slide 87
                                                                              • Hypokalemia
                                                                              • Potassium changes associated with alkalosis
                                                                              • Slide 90
                                                                              • Clinical Manifestation of Abnormalities in potassium
                                                                              • Slide 92
                                                                              • Calcium
                                                                              • هيپوكلسمي یونیزه Calt45 meql
                                                                              • علائم هیپوکلسمی
                                                                              • Slide 96
                                                                              • Slide 97
                                                                              • Slide 98
                                                                              • Slide 99
                                                                              • سایرعلائم
                                                                              • درمان
                                                                              • هيپركلسمي Cagt55meql
                                                                              • علائم
                                                                              • علائم قلبی
                                                                              • Slide 105
                                                                              • Magnesium Abnormalities
                                                                              • منیزیوم
                                                                              • Hypermagnesemia
                                                                              • Clinical manifestation hypermanesemia
                                                                              • Slide 110
                                                                              • Slide 111
                                                                              • Hypomagnesemia
                                                                              • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                              • Slide 114
                                                                              • Message for Today
                                                                              • Slide 116

                                                                                Perioperative management of fluid balance include

                                                                                1 Preoperative evaluation

                                                                                2 Intraoperative maintenance

                                                                                3 Replacement of fluid losses

                                                                                Preexisting fluid deficits

                                                                                bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                                                                bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                                                                Maintenance requirements

                                                                                bull Up to 10 kg = 4cckghr

                                                                                bull 11-20kg = add 2cckghr

                                                                                bull 21kg and above = add 1cckghr

                                                                                bull Insensible losses = 2cckghr

                                                                                Surgical fluid losses

                                                                                Blood loss (measurement)

                                                                                1 Suction container

                                                                                2 Surgical sponge

                                                                                3 Hct and tachycardia not specific

                                                                                4 ABG and UO if hypoperfusion occur

                                                                                5 Blood loss=31 with crystalloid

                                                                                Other losses (third space loss)

                                                                                Third space loss

                                                                                1 Minimal (herniorrapy) =2-4cckghr

                                                                                2 Moderate (cholecystectomy)=4-6cckghr

                                                                                3 Severe (bowel resection) = 6-8cckghr

                                                                                Crystalloid solution

                                                                                1 The main solutions is either glucose or saline

                                                                                2 Hypotonic or isotonic or hypertonic

                                                                                3 Safe nontoxic reaction free inexpensive

                                                                                4 Complication is edema if large volumes are needed

                                                                                5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                                                Colloids

                                                                                1 Albumin

                                                                                2 Hydroxyethyl starch

                                                                                3 Dextran

                                                                                Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                                                factor )These colloid is best avoided in patients with

                                                                                coagulopaty

                                                                                The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                                                1000cc

                                                                                500cc

                                                                                500cc

                                                                                500cc

                                                                                200

                                                                                600

                                                                                1000

                                                                                Lactated Ringers

                                                                                5 Albumin

                                                                                6 Hetastarch

                                                                                Whole blood

                                                                                Blood volumeInfusion volume

                                                                                Colloid versus crystalloid solutions

                                                                                Transfusion consideration

                                                                                bull HB lt7 mg dl increase CO

                                                                                bull Ideal Hb is 7-8 mgdl

                                                                                bull In IHD patients or pulmonary disease gt 10 mgdl

                                                                                بدن مایعات حجم در اختالل

                                                                                1 Fluid volume deficit

                                                                                2 Fluid volume excess

                                                                                Fluid volume deficit(FVD)

                                                                                ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                                کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                                ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                                باشد آن با همراه دیگری اختالل مگر

                                                                                DEHYDRATION

                                                                                سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                                سلولی خارج حجم کاهش علل

                                                                                1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                                2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                                کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                                Signs of HypovolemiaSigns of Hypovolemia

                                                                                bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                                Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                                bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                                Signs of HypervolemiaSigns of Hypervolemia

                                                                                bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                                Especially when hypo-albuminemia

                                                                                Management of Management of HypervolemiaHypervolemia

                                                                                bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                                Fluid ManagementFluid Management

                                                                                bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                Electrolyte physiology

                                                                                Sodium physiology

                                                                                Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                Normal amount 135-145 meql

                                                                                Osmotic Pressure

                                                                                Calculated serum osmolality =

                                                                                2 sodium+ glucose18 + BUN 28

                                                                                Osmolality = 290 mosm

                                                                                Concentration

                                                                                1Serum sodium concentration2Serum osmolarity

                                                                                bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                DW5)

                                                                                Hypernatremia

                                                                                Serum Nagt145mEqL

                                                                                - Hypernatremia

                                                                                Loss of Free Water

                                                                                Gain of sodium in excess of water

                                                                                Hypernatremia

                                                                                -Hypernatremia Hypo volemic

                                                                                Hyper volemic

                                                                                Normo volemic

                                                                                Hypernatremia

                                                                                Volume Status

                                                                                Normal

                                                                                Nonrenal water loss

                                                                                Skin

                                                                                Gastrointestinal

                                                                                Renal water loss

                                                                                Renal disease

                                                                                Diuretics

                                                                                Diabetes insipidus

                                                                                High

                                                                                Iatrogenic sodium administration

                                                                                Mineralocorticoid excess

                                                                                Aldosteronism

                                                                                Cushingrsquos disease

                                                                                Congenital adrenal

                                                                                hyperplasia

                                                                                Low

                                                                                Nonrenal water loss

                                                                                Skin

                                                                                Gastrointestinal losses

                                                                                Renal water losses

                                                                                Renal (tubular) Diuretics

                                                                                Osmotic diuretics

                                                                                Diabetes insipidus

                                                                                Adrenal failure

                                                                                Asymptomatic

                                                                                Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                Body system hypernatremia

                                                                                Treatment

                                                                                Normal saline in hypovolemic patients

                                                                                Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                saline or entral water)

                                                                                Water deficit (L)= times TBW

                                                                                The formula used to estimate the amount of water required to correct hypernatremia

                                                                                Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                Serum sodium-140

                                                                                140

                                                                                The rate of fluid administration

                                                                                1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                Hyponatremia Nalt135mEqL

                                                                                Causes

                                                                                1 Sodium depletion

                                                                                2 Sodium dilution

                                                                                bull Incidence = 45

                                                                                bull After surgery=1

                                                                                bull Mortality = 2 times normal

                                                                                Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                volume deficit

                                                                                Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                Sign and symptoms

                                                                                bull CNS symptom when Nalt123 meql

                                                                                bull Cardiac symptom when Nalt100 meql

                                                                                For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                Body System Hyponatremia

                                                                                central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                reflexes seizures coma increased intracranial pressure

                                                                                Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                intracranial pressure

                                                                                Tissue Lacrimation salivation

                                                                                Renal Oliguria

                                                                                Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                Treatment

                                                                                1=Depend on ECF

                                                                                2=CNS sign

                                                                                Treatment

                                                                                1 Asymptomatic increase the sodium level by no more than

                                                                                05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                more than 1meqL per hour until the serum Na level reaches 130

                                                                                meqL or neurologic symptoms are improved

                                                                                Rapid correction of hyponatremia

                                                                                Pontine myelinolysis

                                                                                Seizures weaknessparesis akinetic

                                                                                movements unresponsiveness

                                                                                Permanent brain damage

                                                                                Death

                                                                                Dose

                                                                                Na deficit meq =(140- Na meql) TBW

                                                                                باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                شود اصالح آهسته سپس

                                                                                Potassium abnormalities

                                                                                bull The average dietary intake of potassium 50-100meqd

                                                                                bull The average renal excretion of potassium 10-700 meqd

                                                                                - 2 of the total body potassium in ECF (45meqL)

                                                                                - Factors that influence serum potassium

                                                                                1 Surgical stress

                                                                                2 Injury

                                                                                3 Acidosis

                                                                                4 Tissue catabolism

                                                                                Hyperkalemia

                                                                                The normal range of serum potassium 35-5 meqL

                                                                                Etiology of Hyperkalemia

                                                                                Increased intake Potassium supplementation

                                                                                Blood transfusions

                                                                                Endogenous loaddestruction

                                                                                hemolysis rhabdomyolysis

                                                                                cruch injury gastrointestinal hemorrhage

                                                                                Increased release Acidosis

                                                                                Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                Renal insufficiencyfailure

                                                                                Clinical manifestation of hyperkalemia

                                                                                System hyperkalemia

                                                                                Gastrointestinal Nauseavomiting colic diarrhea

                                                                                Neuromuscular weakness paralysis respiratory failure

                                                                                Cardiovascular Arrhythmia arrest

                                                                                ECG changes Peaked T waves (early change)

                                                                                Flattened P wave

                                                                                Prolonged PR interval (first-degree block)

                                                                                Widened QRS complex

                                                                                Sine wave formation

                                                                                Ventricular fibrillation

                                                                                Treatment

                                                                                Treatment of symptomatic hyperkalemia

                                                                                Potassium removal Kayexalate

                                                                                Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                Dialysis

                                                                                Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                Bicarbonate 1 vial intravenous

                                                                                Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                HypokalemiaEtiology

                                                                                inadequate intake

                                                                                Dietary potassium-free intravenous fluids potassium-deficient

                                                                                total parenteral nutrition

                                                                                Excessive potassium excretion

                                                                                Hyperaldosteronism

                                                                                Medications

                                                                                Gastrointestinal losses

                                                                                Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                nasogastric output)

                                                                                Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                Potassium changes associated with alkalosis

                                                                                Potassium decrease by 03 meqL for every 01

                                                                                increase in PH above normal

                                                                                Magnesium Depletion

                                                                                (drug induced amphotericin amioglycosides cisplatin)

                                                                                Renal potassium wastage

                                                                                Hypokalemia

                                                                                Magnesium Depletion

                                                                                (drug induced amphotericin amioglycosides cisplatin)

                                                                                Renal potassium wastage

                                                                                Hypokalemia

                                                                                Clinical Manifestation of Abnormalities in potassium

                                                                                System hypokalemia

                                                                                Gastrointestinal Ileus constipation

                                                                                Neuromuscular Decreased reflexes fatigue weakness

                                                                                paralysis

                                                                                Cardiovascular Arrest

                                                                                ECG changes U-waves

                                                                                T-wave flattening

                                                                                ST-segment changes

                                                                                Arrhythmias

                                                                                Treatment

                                                                                Potassium

                                                                                Serum potassium level lt40 mEqL

                                                                                Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                times 1 doses

                                                                                Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                asymptomatic replace as per above protocol

                                                                                Electrolyte Replacement Therapy Protocol

                                                                                bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                bull IV repletion for severe and symptomatic hypokalemia

                                                                                Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                صاف 2 عضالت انقباض

                                                                                هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                انعقاد 4

                                                                                یونیزه Calt45 meql هيپوكلسمي

                                                                                عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                ( شود می پیوند شده

                                                                                هیپوکلسمی عالئم

                                                                                رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                سایرعالئم

                                                                                قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                درمان

                                                                                ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                Cagt55meql هيپركلسمي

                                                                                هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                عالئم

                                                                                bullGI

                                                                                bullCardiovascular bullRenal (polyuria)

                                                                                bullCNS

                                                                                قلبی عالئم

                                                                                bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                QRS شدن )Q-Tوكوتاه

                                                                                درمان

                                                                                ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                الزیکس2

                                                                                تونین 3 کلسی

                                                                                کورتون4

                                                                                دیالیز5

                                                                                Magnesium Abnormalities

                                                                                Normal dietary intake 20meq (240mg)

                                                                                Excretion in both the feces and urine

                                                                                Normal serum level 19-25 mgdL

                                                                                منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                Hypermagnesemia

                                                                                Etiology

                                                                                1 Impaired renal function

                                                                                2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                Clinical manifestation hypermanesemia

                                                                                System hypermanesemia

                                                                                Gastrointestinal Nauseavomiting

                                                                                Neuromuscular weakness lethargy Decreased

                                                                                reflexes

                                                                                Cardiovascular Hypotension arrest

                                                                                ECG changes Increased PR interval

                                                                                Widened QRS complex

                                                                                Elevated T waves

                                                                                Treatment

                                                                                1 Withhold exogenous sources of magnesium

                                                                                2 Correct volume deficit

                                                                                3 Correct acidosis if present

                                                                                4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                5 Dialysis (if elevated levels or symptoms persist)

                                                                                عالئم

                                                                                bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                meqL

                                                                                Hypomagnesemia

                                                                                Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                homeostasis

                                                                                Etiology

                                                                                1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                inadequate supplementation of magnesium)

                                                                                2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                3 GI losses (diarrhea)

                                                                                4 Malabsorption

                                                                                5 Acute pancreatitis

                                                                                6 Diabetic ketoacidosis

                                                                                7 Primary aldosteronism

                                                                                Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                2 Delirium and seizures in severe deficiency

                                                                                3 ECG changes Prolonged QT and PR interval

                                                                                ST-segment depression

                                                                                Flattening or inversion of P waves

                                                                                Torsades de pointes

                                                                                Arrhythmia

                                                                                Treatment

                                                                                1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                Message for Today

                                                                                ICF

                                                                                Interstitial

                                                                                Pla

                                                                                sma

                                                                                5 Dex

                                                                                bull Do not reccussitate sick patients with any Dextrose solution

                                                                                • Fluid and Electrolyte Management of the Surgical Patient
                                                                                • Slide 2
                                                                                • Slide 3
                                                                                • Slide 4
                                                                                • Total Body Water
                                                                                • Body Fluid Compartments
                                                                                • Total body water (TBW)
                                                                                • Body compartment fluid
                                                                                • Example men with 70kg
                                                                                • Fluid compartments
                                                                                • Slide 11
                                                                                • Slide 12
                                                                                • Slide 13
                                                                                • Slide 14
                                                                                • Slide 15
                                                                                • Colloid osmotic pressure
                                                                                • Slide 17
                                                                                • Slide 18
                                                                                • Slide 19
                                                                                • Cell Membrane
                                                                                • Slide 21
                                                                                • Slide 22
                                                                                • Slide 23
                                                                                • Slide 24
                                                                                • Slide 25
                                                                                • Composition of Fluid Compartments
                                                                                • Composition of Body Fluids
                                                                                • عوامل موثر روی تغییرات آب والکترولیت
                                                                                • Reasons for fluid therapy
                                                                                • ارزیابی حجم مایع داخل عروقی
                                                                                • محلولهای وریدی
                                                                                • Fluids
                                                                                • Slide 33
                                                                                • Slide 34
                                                                                • Slide 35
                                                                                • Crystalloids
                                                                                • Colloid Solutions
                                                                                • رینگر لاکتات
                                                                                • 09Nacl
                                                                                • Postoperative (maintenance)
                                                                                • Slide 41
                                                                                • Preexisting fluid deficits
                                                                                • Maintenance requirements
                                                                                • Surgical fluid losses
                                                                                • Third space loss
                                                                                • Crystalloid solution
                                                                                • Colloids
                                                                                • Complications
                                                                                • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                • Colloid versus crystalloid solutions
                                                                                • Transfusion consideration
                                                                                • اختلال در حجم مایعات بدن
                                                                                • Fluid volume deficit (FVD)
                                                                                • DEHYDRATION
                                                                                • علل کاهش حجم خارج سلولی
                                                                                • Signs of Hypovolemia
                                                                                • Clinical Diagnosis of Hypovolemia
                                                                                • Signs of Hypervolemia
                                                                                • Management of Hypervolemia
                                                                                • Fluid Management
                                                                                • Electrolyte physiology
                                                                                • Sodium physiology
                                                                                • Osmotic Pressure
                                                                                • Concentration
                                                                                • Hypernatremia
                                                                                • - Hypernatremia
                                                                                • Slide 67
                                                                                • Slide 68
                                                                                • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                • Treatment
                                                                                • Water deficit (L)= times TBW
                                                                                • The rate of fluid administration
                                                                                • Hyponatremia Nalt135mEqL
                                                                                • Slide 74
                                                                                • Sodium depletion
                                                                                • Sodium dilution
                                                                                • Sign and symptoms
                                                                                • Slide 78
                                                                                • Treatment
                                                                                • Slide 80
                                                                                • Slide 81
                                                                                • Dose
                                                                                • Potassium abnormalities
                                                                                • Hyperkalemia
                                                                                • Clinical manifestation of hyperkalemia
                                                                                • Slide 86
                                                                                • Slide 87
                                                                                • Hypokalemia
                                                                                • Potassium changes associated with alkalosis
                                                                                • Slide 90
                                                                                • Clinical Manifestation of Abnormalities in potassium
                                                                                • Slide 92
                                                                                • Calcium
                                                                                • هيپوكلسمي یونیزه Calt45 meql
                                                                                • علائم هیپوکلسمی
                                                                                • Slide 96
                                                                                • Slide 97
                                                                                • Slide 98
                                                                                • Slide 99
                                                                                • سایرعلائم
                                                                                • درمان
                                                                                • هيپركلسمي Cagt55meql
                                                                                • علائم
                                                                                • علائم قلبی
                                                                                • Slide 105
                                                                                • Magnesium Abnormalities
                                                                                • منیزیوم
                                                                                • Hypermagnesemia
                                                                                • Clinical manifestation hypermanesemia
                                                                                • Slide 110
                                                                                • Slide 111
                                                                                • Hypomagnesemia
                                                                                • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                • Slide 114
                                                                                • Message for Today
                                                                                • Slide 116

                                                                                  Preexisting fluid deficits

                                                                                  bull NPO time and abnormal fluid losses (vomiting-dirreha- asites- infected tissue-fever ndashsweating- hyperventilation)

                                                                                  bull Hypotonic fluid (05 saline ) or isotonic crystalloids

                                                                                  Maintenance requirements

                                                                                  bull Up to 10 kg = 4cckghr

                                                                                  bull 11-20kg = add 2cckghr

                                                                                  bull 21kg and above = add 1cckghr

                                                                                  bull Insensible losses = 2cckghr

                                                                                  Surgical fluid losses

                                                                                  Blood loss (measurement)

                                                                                  1 Suction container

                                                                                  2 Surgical sponge

                                                                                  3 Hct and tachycardia not specific

                                                                                  4 ABG and UO if hypoperfusion occur

                                                                                  5 Blood loss=31 with crystalloid

                                                                                  Other losses (third space loss)

                                                                                  Third space loss

                                                                                  1 Minimal (herniorrapy) =2-4cckghr

                                                                                  2 Moderate (cholecystectomy)=4-6cckghr

                                                                                  3 Severe (bowel resection) = 6-8cckghr

                                                                                  Crystalloid solution

                                                                                  1 The main solutions is either glucose or saline

                                                                                  2 Hypotonic or isotonic or hypertonic

                                                                                  3 Safe nontoxic reaction free inexpensive

                                                                                  4 Complication is edema if large volumes are needed

                                                                                  5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                                                  Colloids

                                                                                  1 Albumin

                                                                                  2 Hydroxyethyl starch

                                                                                  3 Dextran

                                                                                  Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                                                  factor )These colloid is best avoided in patients with

                                                                                  coagulopaty

                                                                                  The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                                                  1000cc

                                                                                  500cc

                                                                                  500cc

                                                                                  500cc

                                                                                  200

                                                                                  600

                                                                                  1000

                                                                                  Lactated Ringers

                                                                                  5 Albumin

                                                                                  6 Hetastarch

                                                                                  Whole blood

                                                                                  Blood volumeInfusion volume

                                                                                  Colloid versus crystalloid solutions

                                                                                  Transfusion consideration

                                                                                  bull HB lt7 mg dl increase CO

                                                                                  bull Ideal Hb is 7-8 mgdl

                                                                                  bull In IHD patients or pulmonary disease gt 10 mgdl

                                                                                  بدن مایعات حجم در اختالل

                                                                                  1 Fluid volume deficit

                                                                                  2 Fluid volume excess

                                                                                  Fluid volume deficit(FVD)

                                                                                  ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                                  کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                                  ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                                  باشد آن با همراه دیگری اختالل مگر

                                                                                  DEHYDRATION

                                                                                  سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                                  سلولی خارج حجم کاهش علل

                                                                                  1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                                  2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                                  کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                                  Signs of HypovolemiaSigns of Hypovolemia

                                                                                  bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                                  Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                                  bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                                  Signs of HypervolemiaSigns of Hypervolemia

                                                                                  bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                                  Especially when hypo-albuminemia

                                                                                  Management of Management of HypervolemiaHypervolemia

                                                                                  bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                                  Fluid ManagementFluid Management

                                                                                  bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                  Electrolyte physiology

                                                                                  Sodium physiology

                                                                                  Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                  Normal amount 135-145 meql

                                                                                  Osmotic Pressure

                                                                                  Calculated serum osmolality =

                                                                                  2 sodium+ glucose18 + BUN 28

                                                                                  Osmolality = 290 mosm

                                                                                  Concentration

                                                                                  1Serum sodium concentration2Serum osmolarity

                                                                                  bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                  drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                  DW5)

                                                                                  Hypernatremia

                                                                                  Serum Nagt145mEqL

                                                                                  - Hypernatremia

                                                                                  Loss of Free Water

                                                                                  Gain of sodium in excess of water

                                                                                  Hypernatremia

                                                                                  -Hypernatremia Hypo volemic

                                                                                  Hyper volemic

                                                                                  Normo volemic

                                                                                  Hypernatremia

                                                                                  Volume Status

                                                                                  Normal

                                                                                  Nonrenal water loss

                                                                                  Skin

                                                                                  Gastrointestinal

                                                                                  Renal water loss

                                                                                  Renal disease

                                                                                  Diuretics

                                                                                  Diabetes insipidus

                                                                                  High

                                                                                  Iatrogenic sodium administration

                                                                                  Mineralocorticoid excess

                                                                                  Aldosteronism

                                                                                  Cushingrsquos disease

                                                                                  Congenital adrenal

                                                                                  hyperplasia

                                                                                  Low

                                                                                  Nonrenal water loss

                                                                                  Skin

                                                                                  Gastrointestinal losses

                                                                                  Renal water losses

                                                                                  Renal (tubular) Diuretics

                                                                                  Osmotic diuretics

                                                                                  Diabetes insipidus

                                                                                  Adrenal failure

                                                                                  Asymptomatic

                                                                                  Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                  Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                  Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                  Body system hypernatremia

                                                                                  Treatment

                                                                                  Normal saline in hypovolemic patients

                                                                                  Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                  saline or entral water)

                                                                                  Water deficit (L)= times TBW

                                                                                  The formula used to estimate the amount of water required to correct hypernatremia

                                                                                  Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                  Serum sodium-140

                                                                                  140

                                                                                  The rate of fluid administration

                                                                                  1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                  2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                  Hyponatremia Nalt135mEqL

                                                                                  Causes

                                                                                  1 Sodium depletion

                                                                                  2 Sodium dilution

                                                                                  bull Incidence = 45

                                                                                  bull After surgery=1

                                                                                  bull Mortality = 2 times normal

                                                                                  Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                  volume deficit

                                                                                  Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                  Sign and symptoms

                                                                                  bull CNS symptom when Nalt123 meql

                                                                                  bull Cardiac symptom when Nalt100 meql

                                                                                  For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                  Body System Hyponatremia

                                                                                  central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                  reflexes seizures coma increased intracranial pressure

                                                                                  Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                  Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                  Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                  intracranial pressure

                                                                                  Tissue Lacrimation salivation

                                                                                  Renal Oliguria

                                                                                  Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                  Treatment

                                                                                  1=Depend on ECF

                                                                                  2=CNS sign

                                                                                  Treatment

                                                                                  1 Asymptomatic increase the sodium level by no more than

                                                                                  05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                  2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                  more than 1meqL per hour until the serum Na level reaches 130

                                                                                  meqL or neurologic symptoms are improved

                                                                                  Rapid correction of hyponatremia

                                                                                  Pontine myelinolysis

                                                                                  Seizures weaknessparesis akinetic

                                                                                  movements unresponsiveness

                                                                                  Permanent brain damage

                                                                                  Death

                                                                                  Dose

                                                                                  Na deficit meq =(140- Na meql) TBW

                                                                                  باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                  شود اصالح آهسته سپس

                                                                                  Potassium abnormalities

                                                                                  bull The average dietary intake of potassium 50-100meqd

                                                                                  bull The average renal excretion of potassium 10-700 meqd

                                                                                  - 2 of the total body potassium in ECF (45meqL)

                                                                                  - Factors that influence serum potassium

                                                                                  1 Surgical stress

                                                                                  2 Injury

                                                                                  3 Acidosis

                                                                                  4 Tissue catabolism

                                                                                  Hyperkalemia

                                                                                  The normal range of serum potassium 35-5 meqL

                                                                                  Etiology of Hyperkalemia

                                                                                  Increased intake Potassium supplementation

                                                                                  Blood transfusions

                                                                                  Endogenous loaddestruction

                                                                                  hemolysis rhabdomyolysis

                                                                                  cruch injury gastrointestinal hemorrhage

                                                                                  Increased release Acidosis

                                                                                  Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                  Renal insufficiencyfailure

                                                                                  Clinical manifestation of hyperkalemia

                                                                                  System hyperkalemia

                                                                                  Gastrointestinal Nauseavomiting colic diarrhea

                                                                                  Neuromuscular weakness paralysis respiratory failure

                                                                                  Cardiovascular Arrhythmia arrest

                                                                                  ECG changes Peaked T waves (early change)

                                                                                  Flattened P wave

                                                                                  Prolonged PR interval (first-degree block)

                                                                                  Widened QRS complex

                                                                                  Sine wave formation

                                                                                  Ventricular fibrillation

                                                                                  Treatment

                                                                                  Treatment of symptomatic hyperkalemia

                                                                                  Potassium removal Kayexalate

                                                                                  Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                  Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                  Dialysis

                                                                                  Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                  Bicarbonate 1 vial intravenous

                                                                                  Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                  HypokalemiaEtiology

                                                                                  inadequate intake

                                                                                  Dietary potassium-free intravenous fluids potassium-deficient

                                                                                  total parenteral nutrition

                                                                                  Excessive potassium excretion

                                                                                  Hyperaldosteronism

                                                                                  Medications

                                                                                  Gastrointestinal losses

                                                                                  Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                  Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                  nasogastric output)

                                                                                  Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                  Potassium changes associated with alkalosis

                                                                                  Potassium decrease by 03 meqL for every 01

                                                                                  increase in PH above normal

                                                                                  Magnesium Depletion

                                                                                  (drug induced amphotericin amioglycosides cisplatin)

                                                                                  Renal potassium wastage

                                                                                  Hypokalemia

                                                                                  Magnesium Depletion

                                                                                  (drug induced amphotericin amioglycosides cisplatin)

                                                                                  Renal potassium wastage

                                                                                  Hypokalemia

                                                                                  Clinical Manifestation of Abnormalities in potassium

                                                                                  System hypokalemia

                                                                                  Gastrointestinal Ileus constipation

                                                                                  Neuromuscular Decreased reflexes fatigue weakness

                                                                                  paralysis

                                                                                  Cardiovascular Arrest

                                                                                  ECG changes U-waves

                                                                                  T-wave flattening

                                                                                  ST-segment changes

                                                                                  Arrhythmias

                                                                                  Treatment

                                                                                  Potassium

                                                                                  Serum potassium level lt40 mEqL

                                                                                  Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                  times 1 doses

                                                                                  Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                  Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                  Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                  asymptomatic replace as per above protocol

                                                                                  Electrolyte Replacement Therapy Protocol

                                                                                  bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                  bull IV repletion for severe and symptomatic hypokalemia

                                                                                  Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                  ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                  عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                  صاف 2 عضالت انقباض

                                                                                  هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                  انعقاد 4

                                                                                  یونیزه Calt45 meql هيپوكلسمي

                                                                                  عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                  ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                  میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                  ( شود می پیوند شده

                                                                                  هیپوکلسمی عالئم

                                                                                  رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                  سایرعالئم

                                                                                  قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                  درمان

                                                                                  ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                  Cagt55meql هيپركلسمي

                                                                                  هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                  عالئم

                                                                                  bullGI

                                                                                  bullCardiovascular bullRenal (polyuria)

                                                                                  bullCNS

                                                                                  قلبی عالئم

                                                                                  bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                  QRS شدن )Q-Tوكوتاه

                                                                                  درمان

                                                                                  ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                  الزیکس2

                                                                                  تونین 3 کلسی

                                                                                  کورتون4

                                                                                  دیالیز5

                                                                                  Magnesium Abnormalities

                                                                                  Normal dietary intake 20meq (240mg)

                                                                                  Excretion in both the feces and urine

                                                                                  Normal serum level 19-25 mgdL

                                                                                  منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                  تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                  bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                  Hypermagnesemia

                                                                                  Etiology

                                                                                  1 Impaired renal function

                                                                                  2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                  Clinical manifestation hypermanesemia

                                                                                  System hypermanesemia

                                                                                  Gastrointestinal Nauseavomiting

                                                                                  Neuromuscular weakness lethargy Decreased

                                                                                  reflexes

                                                                                  Cardiovascular Hypotension arrest

                                                                                  ECG changes Increased PR interval

                                                                                  Widened QRS complex

                                                                                  Elevated T waves

                                                                                  Treatment

                                                                                  1 Withhold exogenous sources of magnesium

                                                                                  2 Correct volume deficit

                                                                                  3 Correct acidosis if present

                                                                                  4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                  5 Dialysis (if elevated levels or symptoms persist)

                                                                                  عالئم

                                                                                  bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                  meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                  meqL

                                                                                  Hypomagnesemia

                                                                                  Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                  homeostasis

                                                                                  Etiology

                                                                                  1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                  inadequate supplementation of magnesium)

                                                                                  2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                  3 GI losses (diarrhea)

                                                                                  4 Malabsorption

                                                                                  5 Acute pancreatitis

                                                                                  6 Diabetic ketoacidosis

                                                                                  7 Primary aldosteronism

                                                                                  Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                  1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                  2 Delirium and seizures in severe deficiency

                                                                                  3 ECG changes Prolonged QT and PR interval

                                                                                  ST-segment depression

                                                                                  Flattening or inversion of P waves

                                                                                  Torsades de pointes

                                                                                  Arrhythmia

                                                                                  Treatment

                                                                                  1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                  2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                  Message for Today

                                                                                  ICF

                                                                                  Interstitial

                                                                                  Pla

                                                                                  sma

                                                                                  5 Dex

                                                                                  bull Do not reccussitate sick patients with any Dextrose solution

                                                                                  • Fluid and Electrolyte Management of the Surgical Patient
                                                                                  • Slide 2
                                                                                  • Slide 3
                                                                                  • Slide 4
                                                                                  • Total Body Water
                                                                                  • Body Fluid Compartments
                                                                                  • Total body water (TBW)
                                                                                  • Body compartment fluid
                                                                                  • Example men with 70kg
                                                                                  • Fluid compartments
                                                                                  • Slide 11
                                                                                  • Slide 12
                                                                                  • Slide 13
                                                                                  • Slide 14
                                                                                  • Slide 15
                                                                                  • Colloid osmotic pressure
                                                                                  • Slide 17
                                                                                  • Slide 18
                                                                                  • Slide 19
                                                                                  • Cell Membrane
                                                                                  • Slide 21
                                                                                  • Slide 22
                                                                                  • Slide 23
                                                                                  • Slide 24
                                                                                  • Slide 25
                                                                                  • Composition of Fluid Compartments
                                                                                  • Composition of Body Fluids
                                                                                  • عوامل موثر روی تغییرات آب والکترولیت
                                                                                  • Reasons for fluid therapy
                                                                                  • ارزیابی حجم مایع داخل عروقی
                                                                                  • محلولهای وریدی
                                                                                  • Fluids
                                                                                  • Slide 33
                                                                                  • Slide 34
                                                                                  • Slide 35
                                                                                  • Crystalloids
                                                                                  • Colloid Solutions
                                                                                  • رینگر لاکتات
                                                                                  • 09Nacl
                                                                                  • Postoperative (maintenance)
                                                                                  • Slide 41
                                                                                  • Preexisting fluid deficits
                                                                                  • Maintenance requirements
                                                                                  • Surgical fluid losses
                                                                                  • Third space loss
                                                                                  • Crystalloid solution
                                                                                  • Colloids
                                                                                  • Complications
                                                                                  • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                  • Colloid versus crystalloid solutions
                                                                                  • Transfusion consideration
                                                                                  • اختلال در حجم مایعات بدن
                                                                                  • Fluid volume deficit (FVD)
                                                                                  • DEHYDRATION
                                                                                  • علل کاهش حجم خارج سلولی
                                                                                  • Signs of Hypovolemia
                                                                                  • Clinical Diagnosis of Hypovolemia
                                                                                  • Signs of Hypervolemia
                                                                                  • Management of Hypervolemia
                                                                                  • Fluid Management
                                                                                  • Electrolyte physiology
                                                                                  • Sodium physiology
                                                                                  • Osmotic Pressure
                                                                                  • Concentration
                                                                                  • Hypernatremia
                                                                                  • - Hypernatremia
                                                                                  • Slide 67
                                                                                  • Slide 68
                                                                                  • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                  • Treatment
                                                                                  • Water deficit (L)= times TBW
                                                                                  • The rate of fluid administration
                                                                                  • Hyponatremia Nalt135mEqL
                                                                                  • Slide 74
                                                                                  • Sodium depletion
                                                                                  • Sodium dilution
                                                                                  • Sign and symptoms
                                                                                  • Slide 78
                                                                                  • Treatment
                                                                                  • Slide 80
                                                                                  • Slide 81
                                                                                  • Dose
                                                                                  • Potassium abnormalities
                                                                                  • Hyperkalemia
                                                                                  • Clinical manifestation of hyperkalemia
                                                                                  • Slide 86
                                                                                  • Slide 87
                                                                                  • Hypokalemia
                                                                                  • Potassium changes associated with alkalosis
                                                                                  • Slide 90
                                                                                  • Clinical Manifestation of Abnormalities in potassium
                                                                                  • Slide 92
                                                                                  • Calcium
                                                                                  • هيپوكلسمي یونیزه Calt45 meql
                                                                                  • علائم هیپوکلسمی
                                                                                  • Slide 96
                                                                                  • Slide 97
                                                                                  • Slide 98
                                                                                  • Slide 99
                                                                                  • سایرعلائم
                                                                                  • درمان
                                                                                  • هيپركلسمي Cagt55meql
                                                                                  • علائم
                                                                                  • علائم قلبی
                                                                                  • Slide 105
                                                                                  • Magnesium Abnormalities
                                                                                  • منیزیوم
                                                                                  • Hypermagnesemia
                                                                                  • Clinical manifestation hypermanesemia
                                                                                  • Slide 110
                                                                                  • Slide 111
                                                                                  • Hypomagnesemia
                                                                                  • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                  • Slide 114
                                                                                  • Message for Today
                                                                                  • Slide 116

                                                                                    Maintenance requirements

                                                                                    bull Up to 10 kg = 4cckghr

                                                                                    bull 11-20kg = add 2cckghr

                                                                                    bull 21kg and above = add 1cckghr

                                                                                    bull Insensible losses = 2cckghr

                                                                                    Surgical fluid losses

                                                                                    Blood loss (measurement)

                                                                                    1 Suction container

                                                                                    2 Surgical sponge

                                                                                    3 Hct and tachycardia not specific

                                                                                    4 ABG and UO if hypoperfusion occur

                                                                                    5 Blood loss=31 with crystalloid

                                                                                    Other losses (third space loss)

                                                                                    Third space loss

                                                                                    1 Minimal (herniorrapy) =2-4cckghr

                                                                                    2 Moderate (cholecystectomy)=4-6cckghr

                                                                                    3 Severe (bowel resection) = 6-8cckghr

                                                                                    Crystalloid solution

                                                                                    1 The main solutions is either glucose or saline

                                                                                    2 Hypotonic or isotonic or hypertonic

                                                                                    3 Safe nontoxic reaction free inexpensive

                                                                                    4 Complication is edema if large volumes are needed

                                                                                    5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                                                    Colloids

                                                                                    1 Albumin

                                                                                    2 Hydroxyethyl starch

                                                                                    3 Dextran

                                                                                    Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                                                    factor )These colloid is best avoided in patients with

                                                                                    coagulopaty

                                                                                    The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                                                    1000cc

                                                                                    500cc

                                                                                    500cc

                                                                                    500cc

                                                                                    200

                                                                                    600

                                                                                    1000

                                                                                    Lactated Ringers

                                                                                    5 Albumin

                                                                                    6 Hetastarch

                                                                                    Whole blood

                                                                                    Blood volumeInfusion volume

                                                                                    Colloid versus crystalloid solutions

                                                                                    Transfusion consideration

                                                                                    bull HB lt7 mg dl increase CO

                                                                                    bull Ideal Hb is 7-8 mgdl

                                                                                    bull In IHD patients or pulmonary disease gt 10 mgdl

                                                                                    بدن مایعات حجم در اختالل

                                                                                    1 Fluid volume deficit

                                                                                    2 Fluid volume excess

                                                                                    Fluid volume deficit(FVD)

                                                                                    ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                                    کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                                    ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                                    باشد آن با همراه دیگری اختالل مگر

                                                                                    DEHYDRATION

                                                                                    سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                                    سلولی خارج حجم کاهش علل

                                                                                    1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                                    2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                                    کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                                    Signs of HypovolemiaSigns of Hypovolemia

                                                                                    bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                                    Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                                    bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                                    Signs of HypervolemiaSigns of Hypervolemia

                                                                                    bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                                    Especially when hypo-albuminemia

                                                                                    Management of Management of HypervolemiaHypervolemia

                                                                                    bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                                    Fluid ManagementFluid Management

                                                                                    bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                    Electrolyte physiology

                                                                                    Sodium physiology

                                                                                    Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                    Normal amount 135-145 meql

                                                                                    Osmotic Pressure

                                                                                    Calculated serum osmolality =

                                                                                    2 sodium+ glucose18 + BUN 28

                                                                                    Osmolality = 290 mosm

                                                                                    Concentration

                                                                                    1Serum sodium concentration2Serum osmolarity

                                                                                    bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                    drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                    DW5)

                                                                                    Hypernatremia

                                                                                    Serum Nagt145mEqL

                                                                                    - Hypernatremia

                                                                                    Loss of Free Water

                                                                                    Gain of sodium in excess of water

                                                                                    Hypernatremia

                                                                                    -Hypernatremia Hypo volemic

                                                                                    Hyper volemic

                                                                                    Normo volemic

                                                                                    Hypernatremia

                                                                                    Volume Status

                                                                                    Normal

                                                                                    Nonrenal water loss

                                                                                    Skin

                                                                                    Gastrointestinal

                                                                                    Renal water loss

                                                                                    Renal disease

                                                                                    Diuretics

                                                                                    Diabetes insipidus

                                                                                    High

                                                                                    Iatrogenic sodium administration

                                                                                    Mineralocorticoid excess

                                                                                    Aldosteronism

                                                                                    Cushingrsquos disease

                                                                                    Congenital adrenal

                                                                                    hyperplasia

                                                                                    Low

                                                                                    Nonrenal water loss

                                                                                    Skin

                                                                                    Gastrointestinal losses

                                                                                    Renal water losses

                                                                                    Renal (tubular) Diuretics

                                                                                    Osmotic diuretics

                                                                                    Diabetes insipidus

                                                                                    Adrenal failure

                                                                                    Asymptomatic

                                                                                    Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                    Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                    Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                    Body system hypernatremia

                                                                                    Treatment

                                                                                    Normal saline in hypovolemic patients

                                                                                    Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                    saline or entral water)

                                                                                    Water deficit (L)= times TBW

                                                                                    The formula used to estimate the amount of water required to correct hypernatremia

                                                                                    Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                    Serum sodium-140

                                                                                    140

                                                                                    The rate of fluid administration

                                                                                    1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                    2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                    Hyponatremia Nalt135mEqL

                                                                                    Causes

                                                                                    1 Sodium depletion

                                                                                    2 Sodium dilution

                                                                                    bull Incidence = 45

                                                                                    bull After surgery=1

                                                                                    bull Mortality = 2 times normal

                                                                                    Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                    volume deficit

                                                                                    Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                    Sign and symptoms

                                                                                    bull CNS symptom when Nalt123 meql

                                                                                    bull Cardiac symptom when Nalt100 meql

                                                                                    For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                    Body System Hyponatremia

                                                                                    central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                    reflexes seizures coma increased intracranial pressure

                                                                                    Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                    Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                    Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                    intracranial pressure

                                                                                    Tissue Lacrimation salivation

                                                                                    Renal Oliguria

                                                                                    Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                    Treatment

                                                                                    1=Depend on ECF

                                                                                    2=CNS sign

                                                                                    Treatment

                                                                                    1 Asymptomatic increase the sodium level by no more than

                                                                                    05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                    2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                    more than 1meqL per hour until the serum Na level reaches 130

                                                                                    meqL or neurologic symptoms are improved

                                                                                    Rapid correction of hyponatremia

                                                                                    Pontine myelinolysis

                                                                                    Seizures weaknessparesis akinetic

                                                                                    movements unresponsiveness

                                                                                    Permanent brain damage

                                                                                    Death

                                                                                    Dose

                                                                                    Na deficit meq =(140- Na meql) TBW

                                                                                    باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                    شود اصالح آهسته سپس

                                                                                    Potassium abnormalities

                                                                                    bull The average dietary intake of potassium 50-100meqd

                                                                                    bull The average renal excretion of potassium 10-700 meqd

                                                                                    - 2 of the total body potassium in ECF (45meqL)

                                                                                    - Factors that influence serum potassium

                                                                                    1 Surgical stress

                                                                                    2 Injury

                                                                                    3 Acidosis

                                                                                    4 Tissue catabolism

                                                                                    Hyperkalemia

                                                                                    The normal range of serum potassium 35-5 meqL

                                                                                    Etiology of Hyperkalemia

                                                                                    Increased intake Potassium supplementation

                                                                                    Blood transfusions

                                                                                    Endogenous loaddestruction

                                                                                    hemolysis rhabdomyolysis

                                                                                    cruch injury gastrointestinal hemorrhage

                                                                                    Increased release Acidosis

                                                                                    Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                    Renal insufficiencyfailure

                                                                                    Clinical manifestation of hyperkalemia

                                                                                    System hyperkalemia

                                                                                    Gastrointestinal Nauseavomiting colic diarrhea

                                                                                    Neuromuscular weakness paralysis respiratory failure

                                                                                    Cardiovascular Arrhythmia arrest

                                                                                    ECG changes Peaked T waves (early change)

                                                                                    Flattened P wave

                                                                                    Prolonged PR interval (first-degree block)

                                                                                    Widened QRS complex

                                                                                    Sine wave formation

                                                                                    Ventricular fibrillation

                                                                                    Treatment

                                                                                    Treatment of symptomatic hyperkalemia

                                                                                    Potassium removal Kayexalate

                                                                                    Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                    Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                    Dialysis

                                                                                    Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                    Bicarbonate 1 vial intravenous

                                                                                    Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                    HypokalemiaEtiology

                                                                                    inadequate intake

                                                                                    Dietary potassium-free intravenous fluids potassium-deficient

                                                                                    total parenteral nutrition

                                                                                    Excessive potassium excretion

                                                                                    Hyperaldosteronism

                                                                                    Medications

                                                                                    Gastrointestinal losses

                                                                                    Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                    Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                    nasogastric output)

                                                                                    Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                    Potassium changes associated with alkalosis

                                                                                    Potassium decrease by 03 meqL for every 01

                                                                                    increase in PH above normal

                                                                                    Magnesium Depletion

                                                                                    (drug induced amphotericin amioglycosides cisplatin)

                                                                                    Renal potassium wastage

                                                                                    Hypokalemia

                                                                                    Magnesium Depletion

                                                                                    (drug induced amphotericin amioglycosides cisplatin)

                                                                                    Renal potassium wastage

                                                                                    Hypokalemia

                                                                                    Clinical Manifestation of Abnormalities in potassium

                                                                                    System hypokalemia

                                                                                    Gastrointestinal Ileus constipation

                                                                                    Neuromuscular Decreased reflexes fatigue weakness

                                                                                    paralysis

                                                                                    Cardiovascular Arrest

                                                                                    ECG changes U-waves

                                                                                    T-wave flattening

                                                                                    ST-segment changes

                                                                                    Arrhythmias

                                                                                    Treatment

                                                                                    Potassium

                                                                                    Serum potassium level lt40 mEqL

                                                                                    Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                    times 1 doses

                                                                                    Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                    Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                    Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                    asymptomatic replace as per above protocol

                                                                                    Electrolyte Replacement Therapy Protocol

                                                                                    bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                    bull IV repletion for severe and symptomatic hypokalemia

                                                                                    Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                    ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                    عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                    صاف 2 عضالت انقباض

                                                                                    هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                    انعقاد 4

                                                                                    یونیزه Calt45 meql هيپوكلسمي

                                                                                    عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                    ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                    میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                    ( شود می پیوند شده

                                                                                    هیپوکلسمی عالئم

                                                                                    رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                    سایرعالئم

                                                                                    قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                    درمان

                                                                                    ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                    Cagt55meql هيپركلسمي

                                                                                    هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                    عالئم

                                                                                    bullGI

                                                                                    bullCardiovascular bullRenal (polyuria)

                                                                                    bullCNS

                                                                                    قلبی عالئم

                                                                                    bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                    QRS شدن )Q-Tوكوتاه

                                                                                    درمان

                                                                                    ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                    الزیکس2

                                                                                    تونین 3 کلسی

                                                                                    کورتون4

                                                                                    دیالیز5

                                                                                    Magnesium Abnormalities

                                                                                    Normal dietary intake 20meq (240mg)

                                                                                    Excretion in both the feces and urine

                                                                                    Normal serum level 19-25 mgdL

                                                                                    منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                    تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                    bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                    Hypermagnesemia

                                                                                    Etiology

                                                                                    1 Impaired renal function

                                                                                    2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                    Clinical manifestation hypermanesemia

                                                                                    System hypermanesemia

                                                                                    Gastrointestinal Nauseavomiting

                                                                                    Neuromuscular weakness lethargy Decreased

                                                                                    reflexes

                                                                                    Cardiovascular Hypotension arrest

                                                                                    ECG changes Increased PR interval

                                                                                    Widened QRS complex

                                                                                    Elevated T waves

                                                                                    Treatment

                                                                                    1 Withhold exogenous sources of magnesium

                                                                                    2 Correct volume deficit

                                                                                    3 Correct acidosis if present

                                                                                    4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                    5 Dialysis (if elevated levels or symptoms persist)

                                                                                    عالئم

                                                                                    bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                    meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                    meqL

                                                                                    Hypomagnesemia

                                                                                    Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                    homeostasis

                                                                                    Etiology

                                                                                    1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                    inadequate supplementation of magnesium)

                                                                                    2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                    3 GI losses (diarrhea)

                                                                                    4 Malabsorption

                                                                                    5 Acute pancreatitis

                                                                                    6 Diabetic ketoacidosis

                                                                                    7 Primary aldosteronism

                                                                                    Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                    1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                    2 Delirium and seizures in severe deficiency

                                                                                    3 ECG changes Prolonged QT and PR interval

                                                                                    ST-segment depression

                                                                                    Flattening or inversion of P waves

                                                                                    Torsades de pointes

                                                                                    Arrhythmia

                                                                                    Treatment

                                                                                    1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                    2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                    Message for Today

                                                                                    ICF

                                                                                    Interstitial

                                                                                    Pla

                                                                                    sma

                                                                                    5 Dex

                                                                                    bull Do not reccussitate sick patients with any Dextrose solution

                                                                                    • Fluid and Electrolyte Management of the Surgical Patient
                                                                                    • Slide 2
                                                                                    • Slide 3
                                                                                    • Slide 4
                                                                                    • Total Body Water
                                                                                    • Body Fluid Compartments
                                                                                    • Total body water (TBW)
                                                                                    • Body compartment fluid
                                                                                    • Example men with 70kg
                                                                                    • Fluid compartments
                                                                                    • Slide 11
                                                                                    • Slide 12
                                                                                    • Slide 13
                                                                                    • Slide 14
                                                                                    • Slide 15
                                                                                    • Colloid osmotic pressure
                                                                                    • Slide 17
                                                                                    • Slide 18
                                                                                    • Slide 19
                                                                                    • Cell Membrane
                                                                                    • Slide 21
                                                                                    • Slide 22
                                                                                    • Slide 23
                                                                                    • Slide 24
                                                                                    • Slide 25
                                                                                    • Composition of Fluid Compartments
                                                                                    • Composition of Body Fluids
                                                                                    • عوامل موثر روی تغییرات آب والکترولیت
                                                                                    • Reasons for fluid therapy
                                                                                    • ارزیابی حجم مایع داخل عروقی
                                                                                    • محلولهای وریدی
                                                                                    • Fluids
                                                                                    • Slide 33
                                                                                    • Slide 34
                                                                                    • Slide 35
                                                                                    • Crystalloids
                                                                                    • Colloid Solutions
                                                                                    • رینگر لاکتات
                                                                                    • 09Nacl
                                                                                    • Postoperative (maintenance)
                                                                                    • Slide 41
                                                                                    • Preexisting fluid deficits
                                                                                    • Maintenance requirements
                                                                                    • Surgical fluid losses
                                                                                    • Third space loss
                                                                                    • Crystalloid solution
                                                                                    • Colloids
                                                                                    • Complications
                                                                                    • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                    • Colloid versus crystalloid solutions
                                                                                    • Transfusion consideration
                                                                                    • اختلال در حجم مایعات بدن
                                                                                    • Fluid volume deficit (FVD)
                                                                                    • DEHYDRATION
                                                                                    • علل کاهش حجم خارج سلولی
                                                                                    • Signs of Hypovolemia
                                                                                    • Clinical Diagnosis of Hypovolemia
                                                                                    • Signs of Hypervolemia
                                                                                    • Management of Hypervolemia
                                                                                    • Fluid Management
                                                                                    • Electrolyte physiology
                                                                                    • Sodium physiology
                                                                                    • Osmotic Pressure
                                                                                    • Concentration
                                                                                    • Hypernatremia
                                                                                    • - Hypernatremia
                                                                                    • Slide 67
                                                                                    • Slide 68
                                                                                    • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                    • Treatment
                                                                                    • Water deficit (L)= times TBW
                                                                                    • The rate of fluid administration
                                                                                    • Hyponatremia Nalt135mEqL
                                                                                    • Slide 74
                                                                                    • Sodium depletion
                                                                                    • Sodium dilution
                                                                                    • Sign and symptoms
                                                                                    • Slide 78
                                                                                    • Treatment
                                                                                    • Slide 80
                                                                                    • Slide 81
                                                                                    • Dose
                                                                                    • Potassium abnormalities
                                                                                    • Hyperkalemia
                                                                                    • Clinical manifestation of hyperkalemia
                                                                                    • Slide 86
                                                                                    • Slide 87
                                                                                    • Hypokalemia
                                                                                    • Potassium changes associated with alkalosis
                                                                                    • Slide 90
                                                                                    • Clinical Manifestation of Abnormalities in potassium
                                                                                    • Slide 92
                                                                                    • Calcium
                                                                                    • هيپوكلسمي یونیزه Calt45 meql
                                                                                    • علائم هیپوکلسمی
                                                                                    • Slide 96
                                                                                    • Slide 97
                                                                                    • Slide 98
                                                                                    • Slide 99
                                                                                    • سایرعلائم
                                                                                    • درمان
                                                                                    • هيپركلسمي Cagt55meql
                                                                                    • علائم
                                                                                    • علائم قلبی
                                                                                    • Slide 105
                                                                                    • Magnesium Abnormalities
                                                                                    • منیزیوم
                                                                                    • Hypermagnesemia
                                                                                    • Clinical manifestation hypermanesemia
                                                                                    • Slide 110
                                                                                    • Slide 111
                                                                                    • Hypomagnesemia
                                                                                    • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                    • Slide 114
                                                                                    • Message for Today
                                                                                    • Slide 116

                                                                                      Surgical fluid losses

                                                                                      Blood loss (measurement)

                                                                                      1 Suction container

                                                                                      2 Surgical sponge

                                                                                      3 Hct and tachycardia not specific

                                                                                      4 ABG and UO if hypoperfusion occur

                                                                                      5 Blood loss=31 with crystalloid

                                                                                      Other losses (third space loss)

                                                                                      Third space loss

                                                                                      1 Minimal (herniorrapy) =2-4cckghr

                                                                                      2 Moderate (cholecystectomy)=4-6cckghr

                                                                                      3 Severe (bowel resection) = 6-8cckghr

                                                                                      Crystalloid solution

                                                                                      1 The main solutions is either glucose or saline

                                                                                      2 Hypotonic or isotonic or hypertonic

                                                                                      3 Safe nontoxic reaction free inexpensive

                                                                                      4 Complication is edema if large volumes are needed

                                                                                      5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                                                      Colloids

                                                                                      1 Albumin

                                                                                      2 Hydroxyethyl starch

                                                                                      3 Dextran

                                                                                      Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                                                      factor )These colloid is best avoided in patients with

                                                                                      coagulopaty

                                                                                      The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                                                      1000cc

                                                                                      500cc

                                                                                      500cc

                                                                                      500cc

                                                                                      200

                                                                                      600

                                                                                      1000

                                                                                      Lactated Ringers

                                                                                      5 Albumin

                                                                                      6 Hetastarch

                                                                                      Whole blood

                                                                                      Blood volumeInfusion volume

                                                                                      Colloid versus crystalloid solutions

                                                                                      Transfusion consideration

                                                                                      bull HB lt7 mg dl increase CO

                                                                                      bull Ideal Hb is 7-8 mgdl

                                                                                      bull In IHD patients or pulmonary disease gt 10 mgdl

                                                                                      بدن مایعات حجم در اختالل

                                                                                      1 Fluid volume deficit

                                                                                      2 Fluid volume excess

                                                                                      Fluid volume deficit(FVD)

                                                                                      ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                                      کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                                      ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                                      باشد آن با همراه دیگری اختالل مگر

                                                                                      DEHYDRATION

                                                                                      سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                                      سلولی خارج حجم کاهش علل

                                                                                      1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                                      2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                                      کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                                      Signs of HypovolemiaSigns of Hypovolemia

                                                                                      bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                                      Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                                      bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                                      Signs of HypervolemiaSigns of Hypervolemia

                                                                                      bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                                      Especially when hypo-albuminemia

                                                                                      Management of Management of HypervolemiaHypervolemia

                                                                                      bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                                      Fluid ManagementFluid Management

                                                                                      bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                      Electrolyte physiology

                                                                                      Sodium physiology

                                                                                      Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                      Normal amount 135-145 meql

                                                                                      Osmotic Pressure

                                                                                      Calculated serum osmolality =

                                                                                      2 sodium+ glucose18 + BUN 28

                                                                                      Osmolality = 290 mosm

                                                                                      Concentration

                                                                                      1Serum sodium concentration2Serum osmolarity

                                                                                      bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                      drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                      DW5)

                                                                                      Hypernatremia

                                                                                      Serum Nagt145mEqL

                                                                                      - Hypernatremia

                                                                                      Loss of Free Water

                                                                                      Gain of sodium in excess of water

                                                                                      Hypernatremia

                                                                                      -Hypernatremia Hypo volemic

                                                                                      Hyper volemic

                                                                                      Normo volemic

                                                                                      Hypernatremia

                                                                                      Volume Status

                                                                                      Normal

                                                                                      Nonrenal water loss

                                                                                      Skin

                                                                                      Gastrointestinal

                                                                                      Renal water loss

                                                                                      Renal disease

                                                                                      Diuretics

                                                                                      Diabetes insipidus

                                                                                      High

                                                                                      Iatrogenic sodium administration

                                                                                      Mineralocorticoid excess

                                                                                      Aldosteronism

                                                                                      Cushingrsquos disease

                                                                                      Congenital adrenal

                                                                                      hyperplasia

                                                                                      Low

                                                                                      Nonrenal water loss

                                                                                      Skin

                                                                                      Gastrointestinal losses

                                                                                      Renal water losses

                                                                                      Renal (tubular) Diuretics

                                                                                      Osmotic diuretics

                                                                                      Diabetes insipidus

                                                                                      Adrenal failure

                                                                                      Asymptomatic

                                                                                      Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                      Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                      Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                      Body system hypernatremia

                                                                                      Treatment

                                                                                      Normal saline in hypovolemic patients

                                                                                      Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                      saline or entral water)

                                                                                      Water deficit (L)= times TBW

                                                                                      The formula used to estimate the amount of water required to correct hypernatremia

                                                                                      Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                      Serum sodium-140

                                                                                      140

                                                                                      The rate of fluid administration

                                                                                      1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                      2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                      Hyponatremia Nalt135mEqL

                                                                                      Causes

                                                                                      1 Sodium depletion

                                                                                      2 Sodium dilution

                                                                                      bull Incidence = 45

                                                                                      bull After surgery=1

                                                                                      bull Mortality = 2 times normal

                                                                                      Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                      volume deficit

                                                                                      Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                      Sign and symptoms

                                                                                      bull CNS symptom when Nalt123 meql

                                                                                      bull Cardiac symptom when Nalt100 meql

                                                                                      For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                      Body System Hyponatremia

                                                                                      central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                      reflexes seizures coma increased intracranial pressure

                                                                                      Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                      Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                      Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                      intracranial pressure

                                                                                      Tissue Lacrimation salivation

                                                                                      Renal Oliguria

                                                                                      Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                      Treatment

                                                                                      1=Depend on ECF

                                                                                      2=CNS sign

                                                                                      Treatment

                                                                                      1 Asymptomatic increase the sodium level by no more than

                                                                                      05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                      2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                      more than 1meqL per hour until the serum Na level reaches 130

                                                                                      meqL or neurologic symptoms are improved

                                                                                      Rapid correction of hyponatremia

                                                                                      Pontine myelinolysis

                                                                                      Seizures weaknessparesis akinetic

                                                                                      movements unresponsiveness

                                                                                      Permanent brain damage

                                                                                      Death

                                                                                      Dose

                                                                                      Na deficit meq =(140- Na meql) TBW

                                                                                      باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                      شود اصالح آهسته سپس

                                                                                      Potassium abnormalities

                                                                                      bull The average dietary intake of potassium 50-100meqd

                                                                                      bull The average renal excretion of potassium 10-700 meqd

                                                                                      - 2 of the total body potassium in ECF (45meqL)

                                                                                      - Factors that influence serum potassium

                                                                                      1 Surgical stress

                                                                                      2 Injury

                                                                                      3 Acidosis

                                                                                      4 Tissue catabolism

                                                                                      Hyperkalemia

                                                                                      The normal range of serum potassium 35-5 meqL

                                                                                      Etiology of Hyperkalemia

                                                                                      Increased intake Potassium supplementation

                                                                                      Blood transfusions

                                                                                      Endogenous loaddestruction

                                                                                      hemolysis rhabdomyolysis

                                                                                      cruch injury gastrointestinal hemorrhage

                                                                                      Increased release Acidosis

                                                                                      Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                      Renal insufficiencyfailure

                                                                                      Clinical manifestation of hyperkalemia

                                                                                      System hyperkalemia

                                                                                      Gastrointestinal Nauseavomiting colic diarrhea

                                                                                      Neuromuscular weakness paralysis respiratory failure

                                                                                      Cardiovascular Arrhythmia arrest

                                                                                      ECG changes Peaked T waves (early change)

                                                                                      Flattened P wave

                                                                                      Prolonged PR interval (first-degree block)

                                                                                      Widened QRS complex

                                                                                      Sine wave formation

                                                                                      Ventricular fibrillation

                                                                                      Treatment

                                                                                      Treatment of symptomatic hyperkalemia

                                                                                      Potassium removal Kayexalate

                                                                                      Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                      Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                      Dialysis

                                                                                      Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                      Bicarbonate 1 vial intravenous

                                                                                      Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                      HypokalemiaEtiology

                                                                                      inadequate intake

                                                                                      Dietary potassium-free intravenous fluids potassium-deficient

                                                                                      total parenteral nutrition

                                                                                      Excessive potassium excretion

                                                                                      Hyperaldosteronism

                                                                                      Medications

                                                                                      Gastrointestinal losses

                                                                                      Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                      Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                      nasogastric output)

                                                                                      Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                      Potassium changes associated with alkalosis

                                                                                      Potassium decrease by 03 meqL for every 01

                                                                                      increase in PH above normal

                                                                                      Magnesium Depletion

                                                                                      (drug induced amphotericin amioglycosides cisplatin)

                                                                                      Renal potassium wastage

                                                                                      Hypokalemia

                                                                                      Magnesium Depletion

                                                                                      (drug induced amphotericin amioglycosides cisplatin)

                                                                                      Renal potassium wastage

                                                                                      Hypokalemia

                                                                                      Clinical Manifestation of Abnormalities in potassium

                                                                                      System hypokalemia

                                                                                      Gastrointestinal Ileus constipation

                                                                                      Neuromuscular Decreased reflexes fatigue weakness

                                                                                      paralysis

                                                                                      Cardiovascular Arrest

                                                                                      ECG changes U-waves

                                                                                      T-wave flattening

                                                                                      ST-segment changes

                                                                                      Arrhythmias

                                                                                      Treatment

                                                                                      Potassium

                                                                                      Serum potassium level lt40 mEqL

                                                                                      Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                      times 1 doses

                                                                                      Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                      Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                      Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                      asymptomatic replace as per above protocol

                                                                                      Electrolyte Replacement Therapy Protocol

                                                                                      bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                      bull IV repletion for severe and symptomatic hypokalemia

                                                                                      Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                      ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                      عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                      صاف 2 عضالت انقباض

                                                                                      هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                      انعقاد 4

                                                                                      یونیزه Calt45 meql هيپوكلسمي

                                                                                      عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                      ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                      میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                      ( شود می پیوند شده

                                                                                      هیپوکلسمی عالئم

                                                                                      رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                      سایرعالئم

                                                                                      قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                      درمان

                                                                                      ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                      Cagt55meql هيپركلسمي

                                                                                      هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                      عالئم

                                                                                      bullGI

                                                                                      bullCardiovascular bullRenal (polyuria)

                                                                                      bullCNS

                                                                                      قلبی عالئم

                                                                                      bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                      QRS شدن )Q-Tوكوتاه

                                                                                      درمان

                                                                                      ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                      الزیکس2

                                                                                      تونین 3 کلسی

                                                                                      کورتون4

                                                                                      دیالیز5

                                                                                      Magnesium Abnormalities

                                                                                      Normal dietary intake 20meq (240mg)

                                                                                      Excretion in both the feces and urine

                                                                                      Normal serum level 19-25 mgdL

                                                                                      منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                      تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                      bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                      Hypermagnesemia

                                                                                      Etiology

                                                                                      1 Impaired renal function

                                                                                      2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                      Clinical manifestation hypermanesemia

                                                                                      System hypermanesemia

                                                                                      Gastrointestinal Nauseavomiting

                                                                                      Neuromuscular weakness lethargy Decreased

                                                                                      reflexes

                                                                                      Cardiovascular Hypotension arrest

                                                                                      ECG changes Increased PR interval

                                                                                      Widened QRS complex

                                                                                      Elevated T waves

                                                                                      Treatment

                                                                                      1 Withhold exogenous sources of magnesium

                                                                                      2 Correct volume deficit

                                                                                      3 Correct acidosis if present

                                                                                      4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                      5 Dialysis (if elevated levels or symptoms persist)

                                                                                      عالئم

                                                                                      bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                      meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                      meqL

                                                                                      Hypomagnesemia

                                                                                      Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                      homeostasis

                                                                                      Etiology

                                                                                      1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                      inadequate supplementation of magnesium)

                                                                                      2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                      3 GI losses (diarrhea)

                                                                                      4 Malabsorption

                                                                                      5 Acute pancreatitis

                                                                                      6 Diabetic ketoacidosis

                                                                                      7 Primary aldosteronism

                                                                                      Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                      1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                      2 Delirium and seizures in severe deficiency

                                                                                      3 ECG changes Prolonged QT and PR interval

                                                                                      ST-segment depression

                                                                                      Flattening or inversion of P waves

                                                                                      Torsades de pointes

                                                                                      Arrhythmia

                                                                                      Treatment

                                                                                      1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                      2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                      Message for Today

                                                                                      ICF

                                                                                      Interstitial

                                                                                      Pla

                                                                                      sma

                                                                                      5 Dex

                                                                                      bull Do not reccussitate sick patients with any Dextrose solution

                                                                                      • Fluid and Electrolyte Management of the Surgical Patient
                                                                                      • Slide 2
                                                                                      • Slide 3
                                                                                      • Slide 4
                                                                                      • Total Body Water
                                                                                      • Body Fluid Compartments
                                                                                      • Total body water (TBW)
                                                                                      • Body compartment fluid
                                                                                      • Example men with 70kg
                                                                                      • Fluid compartments
                                                                                      • Slide 11
                                                                                      • Slide 12
                                                                                      • Slide 13
                                                                                      • Slide 14
                                                                                      • Slide 15
                                                                                      • Colloid osmotic pressure
                                                                                      • Slide 17
                                                                                      • Slide 18
                                                                                      • Slide 19
                                                                                      • Cell Membrane
                                                                                      • Slide 21
                                                                                      • Slide 22
                                                                                      • Slide 23
                                                                                      • Slide 24
                                                                                      • Slide 25
                                                                                      • Composition of Fluid Compartments
                                                                                      • Composition of Body Fluids
                                                                                      • عوامل موثر روی تغییرات آب والکترولیت
                                                                                      • Reasons for fluid therapy
                                                                                      • ارزیابی حجم مایع داخل عروقی
                                                                                      • محلولهای وریدی
                                                                                      • Fluids
                                                                                      • Slide 33
                                                                                      • Slide 34
                                                                                      • Slide 35
                                                                                      • Crystalloids
                                                                                      • Colloid Solutions
                                                                                      • رینگر لاکتات
                                                                                      • 09Nacl
                                                                                      • Postoperative (maintenance)
                                                                                      • Slide 41
                                                                                      • Preexisting fluid deficits
                                                                                      • Maintenance requirements
                                                                                      • Surgical fluid losses
                                                                                      • Third space loss
                                                                                      • Crystalloid solution
                                                                                      • Colloids
                                                                                      • Complications
                                                                                      • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                      • Colloid versus crystalloid solutions
                                                                                      • Transfusion consideration
                                                                                      • اختلال در حجم مایعات بدن
                                                                                      • Fluid volume deficit (FVD)
                                                                                      • DEHYDRATION
                                                                                      • علل کاهش حجم خارج سلولی
                                                                                      • Signs of Hypovolemia
                                                                                      • Clinical Diagnosis of Hypovolemia
                                                                                      • Signs of Hypervolemia
                                                                                      • Management of Hypervolemia
                                                                                      • Fluid Management
                                                                                      • Electrolyte physiology
                                                                                      • Sodium physiology
                                                                                      • Osmotic Pressure
                                                                                      • Concentration
                                                                                      • Hypernatremia
                                                                                      • - Hypernatremia
                                                                                      • Slide 67
                                                                                      • Slide 68
                                                                                      • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                      • Treatment
                                                                                      • Water deficit (L)= times TBW
                                                                                      • The rate of fluid administration
                                                                                      • Hyponatremia Nalt135mEqL
                                                                                      • Slide 74
                                                                                      • Sodium depletion
                                                                                      • Sodium dilution
                                                                                      • Sign and symptoms
                                                                                      • Slide 78
                                                                                      • Treatment
                                                                                      • Slide 80
                                                                                      • Slide 81
                                                                                      • Dose
                                                                                      • Potassium abnormalities
                                                                                      • Hyperkalemia
                                                                                      • Clinical manifestation of hyperkalemia
                                                                                      • Slide 86
                                                                                      • Slide 87
                                                                                      • Hypokalemia
                                                                                      • Potassium changes associated with alkalosis
                                                                                      • Slide 90
                                                                                      • Clinical Manifestation of Abnormalities in potassium
                                                                                      • Slide 92
                                                                                      • Calcium
                                                                                      • هيپوكلسمي یونیزه Calt45 meql
                                                                                      • علائم هیپوکلسمی
                                                                                      • Slide 96
                                                                                      • Slide 97
                                                                                      • Slide 98
                                                                                      • Slide 99
                                                                                      • سایرعلائم
                                                                                      • درمان
                                                                                      • هيپركلسمي Cagt55meql
                                                                                      • علائم
                                                                                      • علائم قلبی
                                                                                      • Slide 105
                                                                                      • Magnesium Abnormalities
                                                                                      • منیزیوم
                                                                                      • Hypermagnesemia
                                                                                      • Clinical manifestation hypermanesemia
                                                                                      • Slide 110
                                                                                      • Slide 111
                                                                                      • Hypomagnesemia
                                                                                      • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                      • Slide 114
                                                                                      • Message for Today
                                                                                      • Slide 116

                                                                                        Third space loss

                                                                                        1 Minimal (herniorrapy) =2-4cckghr

                                                                                        2 Moderate (cholecystectomy)=4-6cckghr

                                                                                        3 Severe (bowel resection) = 6-8cckghr

                                                                                        Crystalloid solution

                                                                                        1 The main solutions is either glucose or saline

                                                                                        2 Hypotonic or isotonic or hypertonic

                                                                                        3 Safe nontoxic reaction free inexpensive

                                                                                        4 Complication is edema if large volumes are needed

                                                                                        5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                                                        Colloids

                                                                                        1 Albumin

                                                                                        2 Hydroxyethyl starch

                                                                                        3 Dextran

                                                                                        Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                                                        factor )These colloid is best avoided in patients with

                                                                                        coagulopaty

                                                                                        The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                                                        1000cc

                                                                                        500cc

                                                                                        500cc

                                                                                        500cc

                                                                                        200

                                                                                        600

                                                                                        1000

                                                                                        Lactated Ringers

                                                                                        5 Albumin

                                                                                        6 Hetastarch

                                                                                        Whole blood

                                                                                        Blood volumeInfusion volume

                                                                                        Colloid versus crystalloid solutions

                                                                                        Transfusion consideration

                                                                                        bull HB lt7 mg dl increase CO

                                                                                        bull Ideal Hb is 7-8 mgdl

                                                                                        bull In IHD patients or pulmonary disease gt 10 mgdl

                                                                                        بدن مایعات حجم در اختالل

                                                                                        1 Fluid volume deficit

                                                                                        2 Fluid volume excess

                                                                                        Fluid volume deficit(FVD)

                                                                                        ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                                        کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                                        ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                                        باشد آن با همراه دیگری اختالل مگر

                                                                                        DEHYDRATION

                                                                                        سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                                        سلولی خارج حجم کاهش علل

                                                                                        1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                                        2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                                        کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                                        Signs of HypovolemiaSigns of Hypovolemia

                                                                                        bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                                        Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                                        bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                                        Signs of HypervolemiaSigns of Hypervolemia

                                                                                        bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                                        Especially when hypo-albuminemia

                                                                                        Management of Management of HypervolemiaHypervolemia

                                                                                        bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                                        Fluid ManagementFluid Management

                                                                                        bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                        Electrolyte physiology

                                                                                        Sodium physiology

                                                                                        Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                        Normal amount 135-145 meql

                                                                                        Osmotic Pressure

                                                                                        Calculated serum osmolality =

                                                                                        2 sodium+ glucose18 + BUN 28

                                                                                        Osmolality = 290 mosm

                                                                                        Concentration

                                                                                        1Serum sodium concentration2Serum osmolarity

                                                                                        bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                        drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                        DW5)

                                                                                        Hypernatremia

                                                                                        Serum Nagt145mEqL

                                                                                        - Hypernatremia

                                                                                        Loss of Free Water

                                                                                        Gain of sodium in excess of water

                                                                                        Hypernatremia

                                                                                        -Hypernatremia Hypo volemic

                                                                                        Hyper volemic

                                                                                        Normo volemic

                                                                                        Hypernatremia

                                                                                        Volume Status

                                                                                        Normal

                                                                                        Nonrenal water loss

                                                                                        Skin

                                                                                        Gastrointestinal

                                                                                        Renal water loss

                                                                                        Renal disease

                                                                                        Diuretics

                                                                                        Diabetes insipidus

                                                                                        High

                                                                                        Iatrogenic sodium administration

                                                                                        Mineralocorticoid excess

                                                                                        Aldosteronism

                                                                                        Cushingrsquos disease

                                                                                        Congenital adrenal

                                                                                        hyperplasia

                                                                                        Low

                                                                                        Nonrenal water loss

                                                                                        Skin

                                                                                        Gastrointestinal losses

                                                                                        Renal water losses

                                                                                        Renal (tubular) Diuretics

                                                                                        Osmotic diuretics

                                                                                        Diabetes insipidus

                                                                                        Adrenal failure

                                                                                        Asymptomatic

                                                                                        Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                        Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                        Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                        Body system hypernatremia

                                                                                        Treatment

                                                                                        Normal saline in hypovolemic patients

                                                                                        Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                        saline or entral water)

                                                                                        Water deficit (L)= times TBW

                                                                                        The formula used to estimate the amount of water required to correct hypernatremia

                                                                                        Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                        Serum sodium-140

                                                                                        140

                                                                                        The rate of fluid administration

                                                                                        1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                        2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                        Hyponatremia Nalt135mEqL

                                                                                        Causes

                                                                                        1 Sodium depletion

                                                                                        2 Sodium dilution

                                                                                        bull Incidence = 45

                                                                                        bull After surgery=1

                                                                                        bull Mortality = 2 times normal

                                                                                        Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                        volume deficit

                                                                                        Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                        Sign and symptoms

                                                                                        bull CNS symptom when Nalt123 meql

                                                                                        bull Cardiac symptom when Nalt100 meql

                                                                                        For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                        Body System Hyponatremia

                                                                                        central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                        reflexes seizures coma increased intracranial pressure

                                                                                        Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                        Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                        Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                        intracranial pressure

                                                                                        Tissue Lacrimation salivation

                                                                                        Renal Oliguria

                                                                                        Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                        Treatment

                                                                                        1=Depend on ECF

                                                                                        2=CNS sign

                                                                                        Treatment

                                                                                        1 Asymptomatic increase the sodium level by no more than

                                                                                        05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                        2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                        more than 1meqL per hour until the serum Na level reaches 130

                                                                                        meqL or neurologic symptoms are improved

                                                                                        Rapid correction of hyponatremia

                                                                                        Pontine myelinolysis

                                                                                        Seizures weaknessparesis akinetic

                                                                                        movements unresponsiveness

                                                                                        Permanent brain damage

                                                                                        Death

                                                                                        Dose

                                                                                        Na deficit meq =(140- Na meql) TBW

                                                                                        باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                        شود اصالح آهسته سپس

                                                                                        Potassium abnormalities

                                                                                        bull The average dietary intake of potassium 50-100meqd

                                                                                        bull The average renal excretion of potassium 10-700 meqd

                                                                                        - 2 of the total body potassium in ECF (45meqL)

                                                                                        - Factors that influence serum potassium

                                                                                        1 Surgical stress

                                                                                        2 Injury

                                                                                        3 Acidosis

                                                                                        4 Tissue catabolism

                                                                                        Hyperkalemia

                                                                                        The normal range of serum potassium 35-5 meqL

                                                                                        Etiology of Hyperkalemia

                                                                                        Increased intake Potassium supplementation

                                                                                        Blood transfusions

                                                                                        Endogenous loaddestruction

                                                                                        hemolysis rhabdomyolysis

                                                                                        cruch injury gastrointestinal hemorrhage

                                                                                        Increased release Acidosis

                                                                                        Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                        Renal insufficiencyfailure

                                                                                        Clinical manifestation of hyperkalemia

                                                                                        System hyperkalemia

                                                                                        Gastrointestinal Nauseavomiting colic diarrhea

                                                                                        Neuromuscular weakness paralysis respiratory failure

                                                                                        Cardiovascular Arrhythmia arrest

                                                                                        ECG changes Peaked T waves (early change)

                                                                                        Flattened P wave

                                                                                        Prolonged PR interval (first-degree block)

                                                                                        Widened QRS complex

                                                                                        Sine wave formation

                                                                                        Ventricular fibrillation

                                                                                        Treatment

                                                                                        Treatment of symptomatic hyperkalemia

                                                                                        Potassium removal Kayexalate

                                                                                        Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                        Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                        Dialysis

                                                                                        Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                        Bicarbonate 1 vial intravenous

                                                                                        Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                        HypokalemiaEtiology

                                                                                        inadequate intake

                                                                                        Dietary potassium-free intravenous fluids potassium-deficient

                                                                                        total parenteral nutrition

                                                                                        Excessive potassium excretion

                                                                                        Hyperaldosteronism

                                                                                        Medications

                                                                                        Gastrointestinal losses

                                                                                        Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                        Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                        nasogastric output)

                                                                                        Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                        Potassium changes associated with alkalosis

                                                                                        Potassium decrease by 03 meqL for every 01

                                                                                        increase in PH above normal

                                                                                        Magnesium Depletion

                                                                                        (drug induced amphotericin amioglycosides cisplatin)

                                                                                        Renal potassium wastage

                                                                                        Hypokalemia

                                                                                        Magnesium Depletion

                                                                                        (drug induced amphotericin amioglycosides cisplatin)

                                                                                        Renal potassium wastage

                                                                                        Hypokalemia

                                                                                        Clinical Manifestation of Abnormalities in potassium

                                                                                        System hypokalemia

                                                                                        Gastrointestinal Ileus constipation

                                                                                        Neuromuscular Decreased reflexes fatigue weakness

                                                                                        paralysis

                                                                                        Cardiovascular Arrest

                                                                                        ECG changes U-waves

                                                                                        T-wave flattening

                                                                                        ST-segment changes

                                                                                        Arrhythmias

                                                                                        Treatment

                                                                                        Potassium

                                                                                        Serum potassium level lt40 mEqL

                                                                                        Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                        times 1 doses

                                                                                        Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                        Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                        Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                        asymptomatic replace as per above protocol

                                                                                        Electrolyte Replacement Therapy Protocol

                                                                                        bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                        bull IV repletion for severe and symptomatic hypokalemia

                                                                                        Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                        ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                        عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                        صاف 2 عضالت انقباض

                                                                                        هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                        انعقاد 4

                                                                                        یونیزه Calt45 meql هيپوكلسمي

                                                                                        عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                        ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                        میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                        ( شود می پیوند شده

                                                                                        هیپوکلسمی عالئم

                                                                                        رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                        سایرعالئم

                                                                                        قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                        درمان

                                                                                        ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                        Cagt55meql هيپركلسمي

                                                                                        هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                        عالئم

                                                                                        bullGI

                                                                                        bullCardiovascular bullRenal (polyuria)

                                                                                        bullCNS

                                                                                        قلبی عالئم

                                                                                        bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                        QRS شدن )Q-Tوكوتاه

                                                                                        درمان

                                                                                        ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                        الزیکس2

                                                                                        تونین 3 کلسی

                                                                                        کورتون4

                                                                                        دیالیز5

                                                                                        Magnesium Abnormalities

                                                                                        Normal dietary intake 20meq (240mg)

                                                                                        Excretion in both the feces and urine

                                                                                        Normal serum level 19-25 mgdL

                                                                                        منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                        تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                        bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                        Hypermagnesemia

                                                                                        Etiology

                                                                                        1 Impaired renal function

                                                                                        2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                        Clinical manifestation hypermanesemia

                                                                                        System hypermanesemia

                                                                                        Gastrointestinal Nauseavomiting

                                                                                        Neuromuscular weakness lethargy Decreased

                                                                                        reflexes

                                                                                        Cardiovascular Hypotension arrest

                                                                                        ECG changes Increased PR interval

                                                                                        Widened QRS complex

                                                                                        Elevated T waves

                                                                                        Treatment

                                                                                        1 Withhold exogenous sources of magnesium

                                                                                        2 Correct volume deficit

                                                                                        3 Correct acidosis if present

                                                                                        4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                        5 Dialysis (if elevated levels or symptoms persist)

                                                                                        عالئم

                                                                                        bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                        meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                        meqL

                                                                                        Hypomagnesemia

                                                                                        Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                        homeostasis

                                                                                        Etiology

                                                                                        1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                        inadequate supplementation of magnesium)

                                                                                        2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                        3 GI losses (diarrhea)

                                                                                        4 Malabsorption

                                                                                        5 Acute pancreatitis

                                                                                        6 Diabetic ketoacidosis

                                                                                        7 Primary aldosteronism

                                                                                        Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                        1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                        2 Delirium and seizures in severe deficiency

                                                                                        3 ECG changes Prolonged QT and PR interval

                                                                                        ST-segment depression

                                                                                        Flattening or inversion of P waves

                                                                                        Torsades de pointes

                                                                                        Arrhythmia

                                                                                        Treatment

                                                                                        1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                        2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                        Message for Today

                                                                                        ICF

                                                                                        Interstitial

                                                                                        Pla

                                                                                        sma

                                                                                        5 Dex

                                                                                        bull Do not reccussitate sick patients with any Dextrose solution

                                                                                        • Fluid and Electrolyte Management of the Surgical Patient
                                                                                        • Slide 2
                                                                                        • Slide 3
                                                                                        • Slide 4
                                                                                        • Total Body Water
                                                                                        • Body Fluid Compartments
                                                                                        • Total body water (TBW)
                                                                                        • Body compartment fluid
                                                                                        • Example men with 70kg
                                                                                        • Fluid compartments
                                                                                        • Slide 11
                                                                                        • Slide 12
                                                                                        • Slide 13
                                                                                        • Slide 14
                                                                                        • Slide 15
                                                                                        • Colloid osmotic pressure
                                                                                        • Slide 17
                                                                                        • Slide 18
                                                                                        • Slide 19
                                                                                        • Cell Membrane
                                                                                        • Slide 21
                                                                                        • Slide 22
                                                                                        • Slide 23
                                                                                        • Slide 24
                                                                                        • Slide 25
                                                                                        • Composition of Fluid Compartments
                                                                                        • Composition of Body Fluids
                                                                                        • عوامل موثر روی تغییرات آب والکترولیت
                                                                                        • Reasons for fluid therapy
                                                                                        • ارزیابی حجم مایع داخل عروقی
                                                                                        • محلولهای وریدی
                                                                                        • Fluids
                                                                                        • Slide 33
                                                                                        • Slide 34
                                                                                        • Slide 35
                                                                                        • Crystalloids
                                                                                        • Colloid Solutions
                                                                                        • رینگر لاکتات
                                                                                        • 09Nacl
                                                                                        • Postoperative (maintenance)
                                                                                        • Slide 41
                                                                                        • Preexisting fluid deficits
                                                                                        • Maintenance requirements
                                                                                        • Surgical fluid losses
                                                                                        • Third space loss
                                                                                        • Crystalloid solution
                                                                                        • Colloids
                                                                                        • Complications
                                                                                        • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                        • Colloid versus crystalloid solutions
                                                                                        • Transfusion consideration
                                                                                        • اختلال در حجم مایعات بدن
                                                                                        • Fluid volume deficit (FVD)
                                                                                        • DEHYDRATION
                                                                                        • علل کاهش حجم خارج سلولی
                                                                                        • Signs of Hypovolemia
                                                                                        • Clinical Diagnosis of Hypovolemia
                                                                                        • Signs of Hypervolemia
                                                                                        • Management of Hypervolemia
                                                                                        • Fluid Management
                                                                                        • Electrolyte physiology
                                                                                        • Sodium physiology
                                                                                        • Osmotic Pressure
                                                                                        • Concentration
                                                                                        • Hypernatremia
                                                                                        • - Hypernatremia
                                                                                        • Slide 67
                                                                                        • Slide 68
                                                                                        • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                        • Treatment
                                                                                        • Water deficit (L)= times TBW
                                                                                        • The rate of fluid administration
                                                                                        • Hyponatremia Nalt135mEqL
                                                                                        • Slide 74
                                                                                        • Sodium depletion
                                                                                        • Sodium dilution
                                                                                        • Sign and symptoms
                                                                                        • Slide 78
                                                                                        • Treatment
                                                                                        • Slide 80
                                                                                        • Slide 81
                                                                                        • Dose
                                                                                        • Potassium abnormalities
                                                                                        • Hyperkalemia
                                                                                        • Clinical manifestation of hyperkalemia
                                                                                        • Slide 86
                                                                                        • Slide 87
                                                                                        • Hypokalemia
                                                                                        • Potassium changes associated with alkalosis
                                                                                        • Slide 90
                                                                                        • Clinical Manifestation of Abnormalities in potassium
                                                                                        • Slide 92
                                                                                        • Calcium
                                                                                        • هيپوكلسمي یونیزه Calt45 meql
                                                                                        • علائم هیپوکلسمی
                                                                                        • Slide 96
                                                                                        • Slide 97
                                                                                        • Slide 98
                                                                                        • Slide 99
                                                                                        • سایرعلائم
                                                                                        • درمان
                                                                                        • هيپركلسمي Cagt55meql
                                                                                        • علائم
                                                                                        • علائم قلبی
                                                                                        • Slide 105
                                                                                        • Magnesium Abnormalities
                                                                                        • منیزیوم
                                                                                        • Hypermagnesemia
                                                                                        • Clinical manifestation hypermanesemia
                                                                                        • Slide 110
                                                                                        • Slide 111
                                                                                        • Hypomagnesemia
                                                                                        • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                        • Slide 114
                                                                                        • Message for Today
                                                                                        • Slide 116

                                                                                          Crystalloid solution

                                                                                          1 The main solutions is either glucose or saline

                                                                                          2 Hypotonic or isotonic or hypertonic

                                                                                          3 Safe nontoxic reaction free inexpensive

                                                                                          4 Complication is edema if large volumes are needed

                                                                                          5 During surgery isotonic solution favored (normal saline - lactate ringer and plasma lyte)

                                                                                          Colloids

                                                                                          1 Albumin

                                                                                          2 Hydroxyethyl starch

                                                                                          3 Dextran

                                                                                          Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                                                          factor )These colloid is best avoided in patients with

                                                                                          coagulopaty

                                                                                          The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                                                          1000cc

                                                                                          500cc

                                                                                          500cc

                                                                                          500cc

                                                                                          200

                                                                                          600

                                                                                          1000

                                                                                          Lactated Ringers

                                                                                          5 Albumin

                                                                                          6 Hetastarch

                                                                                          Whole blood

                                                                                          Blood volumeInfusion volume

                                                                                          Colloid versus crystalloid solutions

                                                                                          Transfusion consideration

                                                                                          bull HB lt7 mg dl increase CO

                                                                                          bull Ideal Hb is 7-8 mgdl

                                                                                          bull In IHD patients or pulmonary disease gt 10 mgdl

                                                                                          بدن مایعات حجم در اختالل

                                                                                          1 Fluid volume deficit

                                                                                          2 Fluid volume excess

                                                                                          Fluid volume deficit(FVD)

                                                                                          ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                                          کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                                          ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                                          باشد آن با همراه دیگری اختالل مگر

                                                                                          DEHYDRATION

                                                                                          سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                                          سلولی خارج حجم کاهش علل

                                                                                          1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                                          2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                                          کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                                          Signs of HypovolemiaSigns of Hypovolemia

                                                                                          bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                                          Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                                          bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                                          Signs of HypervolemiaSigns of Hypervolemia

                                                                                          bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                                          Especially when hypo-albuminemia

                                                                                          Management of Management of HypervolemiaHypervolemia

                                                                                          bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                                          Fluid ManagementFluid Management

                                                                                          bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                          Electrolyte physiology

                                                                                          Sodium physiology

                                                                                          Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                          Normal amount 135-145 meql

                                                                                          Osmotic Pressure

                                                                                          Calculated serum osmolality =

                                                                                          2 sodium+ glucose18 + BUN 28

                                                                                          Osmolality = 290 mosm

                                                                                          Concentration

                                                                                          1Serum sodium concentration2Serum osmolarity

                                                                                          bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                          drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                          DW5)

                                                                                          Hypernatremia

                                                                                          Serum Nagt145mEqL

                                                                                          - Hypernatremia

                                                                                          Loss of Free Water

                                                                                          Gain of sodium in excess of water

                                                                                          Hypernatremia

                                                                                          -Hypernatremia Hypo volemic

                                                                                          Hyper volemic

                                                                                          Normo volemic

                                                                                          Hypernatremia

                                                                                          Volume Status

                                                                                          Normal

                                                                                          Nonrenal water loss

                                                                                          Skin

                                                                                          Gastrointestinal

                                                                                          Renal water loss

                                                                                          Renal disease

                                                                                          Diuretics

                                                                                          Diabetes insipidus

                                                                                          High

                                                                                          Iatrogenic sodium administration

                                                                                          Mineralocorticoid excess

                                                                                          Aldosteronism

                                                                                          Cushingrsquos disease

                                                                                          Congenital adrenal

                                                                                          hyperplasia

                                                                                          Low

                                                                                          Nonrenal water loss

                                                                                          Skin

                                                                                          Gastrointestinal losses

                                                                                          Renal water losses

                                                                                          Renal (tubular) Diuretics

                                                                                          Osmotic diuretics

                                                                                          Diabetes insipidus

                                                                                          Adrenal failure

                                                                                          Asymptomatic

                                                                                          Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                          Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                          Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                          Body system hypernatremia

                                                                                          Treatment

                                                                                          Normal saline in hypovolemic patients

                                                                                          Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                          saline or entral water)

                                                                                          Water deficit (L)= times TBW

                                                                                          The formula used to estimate the amount of water required to correct hypernatremia

                                                                                          Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                          Serum sodium-140

                                                                                          140

                                                                                          The rate of fluid administration

                                                                                          1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                          2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                          Hyponatremia Nalt135mEqL

                                                                                          Causes

                                                                                          1 Sodium depletion

                                                                                          2 Sodium dilution

                                                                                          bull Incidence = 45

                                                                                          bull After surgery=1

                                                                                          bull Mortality = 2 times normal

                                                                                          Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                          volume deficit

                                                                                          Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                          Sign and symptoms

                                                                                          bull CNS symptom when Nalt123 meql

                                                                                          bull Cardiac symptom when Nalt100 meql

                                                                                          For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                          Body System Hyponatremia

                                                                                          central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                          reflexes seizures coma increased intracranial pressure

                                                                                          Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                          Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                          Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                          intracranial pressure

                                                                                          Tissue Lacrimation salivation

                                                                                          Renal Oliguria

                                                                                          Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                          Treatment

                                                                                          1=Depend on ECF

                                                                                          2=CNS sign

                                                                                          Treatment

                                                                                          1 Asymptomatic increase the sodium level by no more than

                                                                                          05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                          2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                          more than 1meqL per hour until the serum Na level reaches 130

                                                                                          meqL or neurologic symptoms are improved

                                                                                          Rapid correction of hyponatremia

                                                                                          Pontine myelinolysis

                                                                                          Seizures weaknessparesis akinetic

                                                                                          movements unresponsiveness

                                                                                          Permanent brain damage

                                                                                          Death

                                                                                          Dose

                                                                                          Na deficit meq =(140- Na meql) TBW

                                                                                          باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                          شود اصالح آهسته سپس

                                                                                          Potassium abnormalities

                                                                                          bull The average dietary intake of potassium 50-100meqd

                                                                                          bull The average renal excretion of potassium 10-700 meqd

                                                                                          - 2 of the total body potassium in ECF (45meqL)

                                                                                          - Factors that influence serum potassium

                                                                                          1 Surgical stress

                                                                                          2 Injury

                                                                                          3 Acidosis

                                                                                          4 Tissue catabolism

                                                                                          Hyperkalemia

                                                                                          The normal range of serum potassium 35-5 meqL

                                                                                          Etiology of Hyperkalemia

                                                                                          Increased intake Potassium supplementation

                                                                                          Blood transfusions

                                                                                          Endogenous loaddestruction

                                                                                          hemolysis rhabdomyolysis

                                                                                          cruch injury gastrointestinal hemorrhage

                                                                                          Increased release Acidosis

                                                                                          Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                          Renal insufficiencyfailure

                                                                                          Clinical manifestation of hyperkalemia

                                                                                          System hyperkalemia

                                                                                          Gastrointestinal Nauseavomiting colic diarrhea

                                                                                          Neuromuscular weakness paralysis respiratory failure

                                                                                          Cardiovascular Arrhythmia arrest

                                                                                          ECG changes Peaked T waves (early change)

                                                                                          Flattened P wave

                                                                                          Prolonged PR interval (first-degree block)

                                                                                          Widened QRS complex

                                                                                          Sine wave formation

                                                                                          Ventricular fibrillation

                                                                                          Treatment

                                                                                          Treatment of symptomatic hyperkalemia

                                                                                          Potassium removal Kayexalate

                                                                                          Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                          Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                          Dialysis

                                                                                          Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                          Bicarbonate 1 vial intravenous

                                                                                          Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                          HypokalemiaEtiology

                                                                                          inadequate intake

                                                                                          Dietary potassium-free intravenous fluids potassium-deficient

                                                                                          total parenteral nutrition

                                                                                          Excessive potassium excretion

                                                                                          Hyperaldosteronism

                                                                                          Medications

                                                                                          Gastrointestinal losses

                                                                                          Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                          Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                          nasogastric output)

                                                                                          Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                          Potassium changes associated with alkalosis

                                                                                          Potassium decrease by 03 meqL for every 01

                                                                                          increase in PH above normal

                                                                                          Magnesium Depletion

                                                                                          (drug induced amphotericin amioglycosides cisplatin)

                                                                                          Renal potassium wastage

                                                                                          Hypokalemia

                                                                                          Magnesium Depletion

                                                                                          (drug induced amphotericin amioglycosides cisplatin)

                                                                                          Renal potassium wastage

                                                                                          Hypokalemia

                                                                                          Clinical Manifestation of Abnormalities in potassium

                                                                                          System hypokalemia

                                                                                          Gastrointestinal Ileus constipation

                                                                                          Neuromuscular Decreased reflexes fatigue weakness

                                                                                          paralysis

                                                                                          Cardiovascular Arrest

                                                                                          ECG changes U-waves

                                                                                          T-wave flattening

                                                                                          ST-segment changes

                                                                                          Arrhythmias

                                                                                          Treatment

                                                                                          Potassium

                                                                                          Serum potassium level lt40 mEqL

                                                                                          Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                          times 1 doses

                                                                                          Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                          Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                          Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                          asymptomatic replace as per above protocol

                                                                                          Electrolyte Replacement Therapy Protocol

                                                                                          bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                          bull IV repletion for severe and symptomatic hypokalemia

                                                                                          Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                          ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                          عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                          صاف 2 عضالت انقباض

                                                                                          هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                          انعقاد 4

                                                                                          یونیزه Calt45 meql هيپوكلسمي

                                                                                          عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                          ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                          میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                          ( شود می پیوند شده

                                                                                          هیپوکلسمی عالئم

                                                                                          رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                          سایرعالئم

                                                                                          قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                          درمان

                                                                                          ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                          Cagt55meql هيپركلسمي

                                                                                          هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                          عالئم

                                                                                          bullGI

                                                                                          bullCardiovascular bullRenal (polyuria)

                                                                                          bullCNS

                                                                                          قلبی عالئم

                                                                                          bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                          QRS شدن )Q-Tوكوتاه

                                                                                          درمان

                                                                                          ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                          الزیکس2

                                                                                          تونین 3 کلسی

                                                                                          کورتون4

                                                                                          دیالیز5

                                                                                          Magnesium Abnormalities

                                                                                          Normal dietary intake 20meq (240mg)

                                                                                          Excretion in both the feces and urine

                                                                                          Normal serum level 19-25 mgdL

                                                                                          منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                          تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                          bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                          Hypermagnesemia

                                                                                          Etiology

                                                                                          1 Impaired renal function

                                                                                          2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                          Clinical manifestation hypermanesemia

                                                                                          System hypermanesemia

                                                                                          Gastrointestinal Nauseavomiting

                                                                                          Neuromuscular weakness lethargy Decreased

                                                                                          reflexes

                                                                                          Cardiovascular Hypotension arrest

                                                                                          ECG changes Increased PR interval

                                                                                          Widened QRS complex

                                                                                          Elevated T waves

                                                                                          Treatment

                                                                                          1 Withhold exogenous sources of magnesium

                                                                                          2 Correct volume deficit

                                                                                          3 Correct acidosis if present

                                                                                          4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                          5 Dialysis (if elevated levels or symptoms persist)

                                                                                          عالئم

                                                                                          bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                          meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                          meqL

                                                                                          Hypomagnesemia

                                                                                          Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                          homeostasis

                                                                                          Etiology

                                                                                          1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                          inadequate supplementation of magnesium)

                                                                                          2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                          3 GI losses (diarrhea)

                                                                                          4 Malabsorption

                                                                                          5 Acute pancreatitis

                                                                                          6 Diabetic ketoacidosis

                                                                                          7 Primary aldosteronism

                                                                                          Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                          1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                          2 Delirium and seizures in severe deficiency

                                                                                          3 ECG changes Prolonged QT and PR interval

                                                                                          ST-segment depression

                                                                                          Flattening or inversion of P waves

                                                                                          Torsades de pointes

                                                                                          Arrhythmia

                                                                                          Treatment

                                                                                          1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                          2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                          Message for Today

                                                                                          ICF

                                                                                          Interstitial

                                                                                          Pla

                                                                                          sma

                                                                                          5 Dex

                                                                                          bull Do not reccussitate sick patients with any Dextrose solution

                                                                                          • Fluid and Electrolyte Management of the Surgical Patient
                                                                                          • Slide 2
                                                                                          • Slide 3
                                                                                          • Slide 4
                                                                                          • Total Body Water
                                                                                          • Body Fluid Compartments
                                                                                          • Total body water (TBW)
                                                                                          • Body compartment fluid
                                                                                          • Example men with 70kg
                                                                                          • Fluid compartments
                                                                                          • Slide 11
                                                                                          • Slide 12
                                                                                          • Slide 13
                                                                                          • Slide 14
                                                                                          • Slide 15
                                                                                          • Colloid osmotic pressure
                                                                                          • Slide 17
                                                                                          • Slide 18
                                                                                          • Slide 19
                                                                                          • Cell Membrane
                                                                                          • Slide 21
                                                                                          • Slide 22
                                                                                          • Slide 23
                                                                                          • Slide 24
                                                                                          • Slide 25
                                                                                          • Composition of Fluid Compartments
                                                                                          • Composition of Body Fluids
                                                                                          • عوامل موثر روی تغییرات آب والکترولیت
                                                                                          • Reasons for fluid therapy
                                                                                          • ارزیابی حجم مایع داخل عروقی
                                                                                          • محلولهای وریدی
                                                                                          • Fluids
                                                                                          • Slide 33
                                                                                          • Slide 34
                                                                                          • Slide 35
                                                                                          • Crystalloids
                                                                                          • Colloid Solutions
                                                                                          • رینگر لاکتات
                                                                                          • 09Nacl
                                                                                          • Postoperative (maintenance)
                                                                                          • Slide 41
                                                                                          • Preexisting fluid deficits
                                                                                          • Maintenance requirements
                                                                                          • Surgical fluid losses
                                                                                          • Third space loss
                                                                                          • Crystalloid solution
                                                                                          • Colloids
                                                                                          • Complications
                                                                                          • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                          • Colloid versus crystalloid solutions
                                                                                          • Transfusion consideration
                                                                                          • اختلال در حجم مایعات بدن
                                                                                          • Fluid volume deficit (FVD)
                                                                                          • DEHYDRATION
                                                                                          • علل کاهش حجم خارج سلولی
                                                                                          • Signs of Hypovolemia
                                                                                          • Clinical Diagnosis of Hypovolemia
                                                                                          • Signs of Hypervolemia
                                                                                          • Management of Hypervolemia
                                                                                          • Fluid Management
                                                                                          • Electrolyte physiology
                                                                                          • Sodium physiology
                                                                                          • Osmotic Pressure
                                                                                          • Concentration
                                                                                          • Hypernatremia
                                                                                          • - Hypernatremia
                                                                                          • Slide 67
                                                                                          • Slide 68
                                                                                          • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                          • Treatment
                                                                                          • Water deficit (L)= times TBW
                                                                                          • The rate of fluid administration
                                                                                          • Hyponatremia Nalt135mEqL
                                                                                          • Slide 74
                                                                                          • Sodium depletion
                                                                                          • Sodium dilution
                                                                                          • Sign and symptoms
                                                                                          • Slide 78
                                                                                          • Treatment
                                                                                          • Slide 80
                                                                                          • Slide 81
                                                                                          • Dose
                                                                                          • Potassium abnormalities
                                                                                          • Hyperkalemia
                                                                                          • Clinical manifestation of hyperkalemia
                                                                                          • Slide 86
                                                                                          • Slide 87
                                                                                          • Hypokalemia
                                                                                          • Potassium changes associated with alkalosis
                                                                                          • Slide 90
                                                                                          • Clinical Manifestation of Abnormalities in potassium
                                                                                          • Slide 92
                                                                                          • Calcium
                                                                                          • هيپوكلسمي یونیزه Calt45 meql
                                                                                          • علائم هیپوکلسمی
                                                                                          • Slide 96
                                                                                          • Slide 97
                                                                                          • Slide 98
                                                                                          • Slide 99
                                                                                          • سایرعلائم
                                                                                          • درمان
                                                                                          • هيپركلسمي Cagt55meql
                                                                                          • علائم
                                                                                          • علائم قلبی
                                                                                          • Slide 105
                                                                                          • Magnesium Abnormalities
                                                                                          • منیزیوم
                                                                                          • Hypermagnesemia
                                                                                          • Clinical manifestation hypermanesemia
                                                                                          • Slide 110
                                                                                          • Slide 111
                                                                                          • Hypomagnesemia
                                                                                          • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                          • Slide 114
                                                                                          • Message for Today
                                                                                          • Slide 116

                                                                                            Colloids

                                                                                            1 Albumin

                                                                                            2 Hydroxyethyl starch

                                                                                            3 Dextran

                                                                                            Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                                                            factor )These colloid is best avoided in patients with

                                                                                            coagulopaty

                                                                                            The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                                                            1000cc

                                                                                            500cc

                                                                                            500cc

                                                                                            500cc

                                                                                            200

                                                                                            600

                                                                                            1000

                                                                                            Lactated Ringers

                                                                                            5 Albumin

                                                                                            6 Hetastarch

                                                                                            Whole blood

                                                                                            Blood volumeInfusion volume

                                                                                            Colloid versus crystalloid solutions

                                                                                            Transfusion consideration

                                                                                            bull HB lt7 mg dl increase CO

                                                                                            bull Ideal Hb is 7-8 mgdl

                                                                                            bull In IHD patients or pulmonary disease gt 10 mgdl

                                                                                            بدن مایعات حجم در اختالل

                                                                                            1 Fluid volume deficit

                                                                                            2 Fluid volume excess

                                                                                            Fluid volume deficit(FVD)

                                                                                            ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                                            کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                                            ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                                            باشد آن با همراه دیگری اختالل مگر

                                                                                            DEHYDRATION

                                                                                            سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                                            سلولی خارج حجم کاهش علل

                                                                                            1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                                            2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                                            کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                                            Signs of HypovolemiaSigns of Hypovolemia

                                                                                            bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                                            Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                                            bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                                            Signs of HypervolemiaSigns of Hypervolemia

                                                                                            bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                                            Especially when hypo-albuminemia

                                                                                            Management of Management of HypervolemiaHypervolemia

                                                                                            bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                                            Fluid ManagementFluid Management

                                                                                            bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                            Electrolyte physiology

                                                                                            Sodium physiology

                                                                                            Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                            Normal amount 135-145 meql

                                                                                            Osmotic Pressure

                                                                                            Calculated serum osmolality =

                                                                                            2 sodium+ glucose18 + BUN 28

                                                                                            Osmolality = 290 mosm

                                                                                            Concentration

                                                                                            1Serum sodium concentration2Serum osmolarity

                                                                                            bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                            drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                            DW5)

                                                                                            Hypernatremia

                                                                                            Serum Nagt145mEqL

                                                                                            - Hypernatremia

                                                                                            Loss of Free Water

                                                                                            Gain of sodium in excess of water

                                                                                            Hypernatremia

                                                                                            -Hypernatremia Hypo volemic

                                                                                            Hyper volemic

                                                                                            Normo volemic

                                                                                            Hypernatremia

                                                                                            Volume Status

                                                                                            Normal

                                                                                            Nonrenal water loss

                                                                                            Skin

                                                                                            Gastrointestinal

                                                                                            Renal water loss

                                                                                            Renal disease

                                                                                            Diuretics

                                                                                            Diabetes insipidus

                                                                                            High

                                                                                            Iatrogenic sodium administration

                                                                                            Mineralocorticoid excess

                                                                                            Aldosteronism

                                                                                            Cushingrsquos disease

                                                                                            Congenital adrenal

                                                                                            hyperplasia

                                                                                            Low

                                                                                            Nonrenal water loss

                                                                                            Skin

                                                                                            Gastrointestinal losses

                                                                                            Renal water losses

                                                                                            Renal (tubular) Diuretics

                                                                                            Osmotic diuretics

                                                                                            Diabetes insipidus

                                                                                            Adrenal failure

                                                                                            Asymptomatic

                                                                                            Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                            Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                            Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                            Body system hypernatremia

                                                                                            Treatment

                                                                                            Normal saline in hypovolemic patients

                                                                                            Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                            saline or entral water)

                                                                                            Water deficit (L)= times TBW

                                                                                            The formula used to estimate the amount of water required to correct hypernatremia

                                                                                            Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                            Serum sodium-140

                                                                                            140

                                                                                            The rate of fluid administration

                                                                                            1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                            2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                            Hyponatremia Nalt135mEqL

                                                                                            Causes

                                                                                            1 Sodium depletion

                                                                                            2 Sodium dilution

                                                                                            bull Incidence = 45

                                                                                            bull After surgery=1

                                                                                            bull Mortality = 2 times normal

                                                                                            Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                            volume deficit

                                                                                            Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                            Sign and symptoms

                                                                                            bull CNS symptom when Nalt123 meql

                                                                                            bull Cardiac symptom when Nalt100 meql

                                                                                            For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                            Body System Hyponatremia

                                                                                            central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                            reflexes seizures coma increased intracranial pressure

                                                                                            Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                            Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                            Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                            intracranial pressure

                                                                                            Tissue Lacrimation salivation

                                                                                            Renal Oliguria

                                                                                            Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                            Treatment

                                                                                            1=Depend on ECF

                                                                                            2=CNS sign

                                                                                            Treatment

                                                                                            1 Asymptomatic increase the sodium level by no more than

                                                                                            05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                            2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                            more than 1meqL per hour until the serum Na level reaches 130

                                                                                            meqL or neurologic symptoms are improved

                                                                                            Rapid correction of hyponatremia

                                                                                            Pontine myelinolysis

                                                                                            Seizures weaknessparesis akinetic

                                                                                            movements unresponsiveness

                                                                                            Permanent brain damage

                                                                                            Death

                                                                                            Dose

                                                                                            Na deficit meq =(140- Na meql) TBW

                                                                                            باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                            شود اصالح آهسته سپس

                                                                                            Potassium abnormalities

                                                                                            bull The average dietary intake of potassium 50-100meqd

                                                                                            bull The average renal excretion of potassium 10-700 meqd

                                                                                            - 2 of the total body potassium in ECF (45meqL)

                                                                                            - Factors that influence serum potassium

                                                                                            1 Surgical stress

                                                                                            2 Injury

                                                                                            3 Acidosis

                                                                                            4 Tissue catabolism

                                                                                            Hyperkalemia

                                                                                            The normal range of serum potassium 35-5 meqL

                                                                                            Etiology of Hyperkalemia

                                                                                            Increased intake Potassium supplementation

                                                                                            Blood transfusions

                                                                                            Endogenous loaddestruction

                                                                                            hemolysis rhabdomyolysis

                                                                                            cruch injury gastrointestinal hemorrhage

                                                                                            Increased release Acidosis

                                                                                            Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                            Renal insufficiencyfailure

                                                                                            Clinical manifestation of hyperkalemia

                                                                                            System hyperkalemia

                                                                                            Gastrointestinal Nauseavomiting colic diarrhea

                                                                                            Neuromuscular weakness paralysis respiratory failure

                                                                                            Cardiovascular Arrhythmia arrest

                                                                                            ECG changes Peaked T waves (early change)

                                                                                            Flattened P wave

                                                                                            Prolonged PR interval (first-degree block)

                                                                                            Widened QRS complex

                                                                                            Sine wave formation

                                                                                            Ventricular fibrillation

                                                                                            Treatment

                                                                                            Treatment of symptomatic hyperkalemia

                                                                                            Potassium removal Kayexalate

                                                                                            Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                            Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                            Dialysis

                                                                                            Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                            Bicarbonate 1 vial intravenous

                                                                                            Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                            HypokalemiaEtiology

                                                                                            inadequate intake

                                                                                            Dietary potassium-free intravenous fluids potassium-deficient

                                                                                            total parenteral nutrition

                                                                                            Excessive potassium excretion

                                                                                            Hyperaldosteronism

                                                                                            Medications

                                                                                            Gastrointestinal losses

                                                                                            Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                            Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                            nasogastric output)

                                                                                            Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                            Potassium changes associated with alkalosis

                                                                                            Potassium decrease by 03 meqL for every 01

                                                                                            increase in PH above normal

                                                                                            Magnesium Depletion

                                                                                            (drug induced amphotericin amioglycosides cisplatin)

                                                                                            Renal potassium wastage

                                                                                            Hypokalemia

                                                                                            Magnesium Depletion

                                                                                            (drug induced amphotericin amioglycosides cisplatin)

                                                                                            Renal potassium wastage

                                                                                            Hypokalemia

                                                                                            Clinical Manifestation of Abnormalities in potassium

                                                                                            System hypokalemia

                                                                                            Gastrointestinal Ileus constipation

                                                                                            Neuromuscular Decreased reflexes fatigue weakness

                                                                                            paralysis

                                                                                            Cardiovascular Arrest

                                                                                            ECG changes U-waves

                                                                                            T-wave flattening

                                                                                            ST-segment changes

                                                                                            Arrhythmias

                                                                                            Treatment

                                                                                            Potassium

                                                                                            Serum potassium level lt40 mEqL

                                                                                            Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                            times 1 doses

                                                                                            Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                            Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                            Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                            asymptomatic replace as per above protocol

                                                                                            Electrolyte Replacement Therapy Protocol

                                                                                            bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                            bull IV repletion for severe and symptomatic hypokalemia

                                                                                            Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                            ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                            عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                            صاف 2 عضالت انقباض

                                                                                            هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                            انعقاد 4

                                                                                            یونیزه Calt45 meql هيپوكلسمي

                                                                                            عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                            ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                            میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                            ( شود می پیوند شده

                                                                                            هیپوکلسمی عالئم

                                                                                            رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                            سایرعالئم

                                                                                            قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                            درمان

                                                                                            ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                            Cagt55meql هيپركلسمي

                                                                                            هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                            عالئم

                                                                                            bullGI

                                                                                            bullCardiovascular bullRenal (polyuria)

                                                                                            bullCNS

                                                                                            قلبی عالئم

                                                                                            bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                            QRS شدن )Q-Tوكوتاه

                                                                                            درمان

                                                                                            ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                            الزیکس2

                                                                                            تونین 3 کلسی

                                                                                            کورتون4

                                                                                            دیالیز5

                                                                                            Magnesium Abnormalities

                                                                                            Normal dietary intake 20meq (240mg)

                                                                                            Excretion in both the feces and urine

                                                                                            Normal serum level 19-25 mgdL

                                                                                            منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                            تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                            bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                            Hypermagnesemia

                                                                                            Etiology

                                                                                            1 Impaired renal function

                                                                                            2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                            Clinical manifestation hypermanesemia

                                                                                            System hypermanesemia

                                                                                            Gastrointestinal Nauseavomiting

                                                                                            Neuromuscular weakness lethargy Decreased

                                                                                            reflexes

                                                                                            Cardiovascular Hypotension arrest

                                                                                            ECG changes Increased PR interval

                                                                                            Widened QRS complex

                                                                                            Elevated T waves

                                                                                            Treatment

                                                                                            1 Withhold exogenous sources of magnesium

                                                                                            2 Correct volume deficit

                                                                                            3 Correct acidosis if present

                                                                                            4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                            5 Dialysis (if elevated levels or symptoms persist)

                                                                                            عالئم

                                                                                            bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                            meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                            meqL

                                                                                            Hypomagnesemia

                                                                                            Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                            homeostasis

                                                                                            Etiology

                                                                                            1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                            inadequate supplementation of magnesium)

                                                                                            2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                            3 GI losses (diarrhea)

                                                                                            4 Malabsorption

                                                                                            5 Acute pancreatitis

                                                                                            6 Diabetic ketoacidosis

                                                                                            7 Primary aldosteronism

                                                                                            Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                            1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                            2 Delirium and seizures in severe deficiency

                                                                                            3 ECG changes Prolonged QT and PR interval

                                                                                            ST-segment depression

                                                                                            Flattening or inversion of P waves

                                                                                            Torsades de pointes

                                                                                            Arrhythmia

                                                                                            Treatment

                                                                                            1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                            2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                            Message for Today

                                                                                            ICF

                                                                                            Interstitial

                                                                                            Pla

                                                                                            sma

                                                                                            5 Dex

                                                                                            bull Do not reccussitate sick patients with any Dextrose solution

                                                                                            • Fluid and Electrolyte Management of the Surgical Patient
                                                                                            • Slide 2
                                                                                            • Slide 3
                                                                                            • Slide 4
                                                                                            • Total Body Water
                                                                                            • Body Fluid Compartments
                                                                                            • Total body water (TBW)
                                                                                            • Body compartment fluid
                                                                                            • Example men with 70kg
                                                                                            • Fluid compartments
                                                                                            • Slide 11
                                                                                            • Slide 12
                                                                                            • Slide 13
                                                                                            • Slide 14
                                                                                            • Slide 15
                                                                                            • Colloid osmotic pressure
                                                                                            • Slide 17
                                                                                            • Slide 18
                                                                                            • Slide 19
                                                                                            • Cell Membrane
                                                                                            • Slide 21
                                                                                            • Slide 22
                                                                                            • Slide 23
                                                                                            • Slide 24
                                                                                            • Slide 25
                                                                                            • Composition of Fluid Compartments
                                                                                            • Composition of Body Fluids
                                                                                            • عوامل موثر روی تغییرات آب والکترولیت
                                                                                            • Reasons for fluid therapy
                                                                                            • ارزیابی حجم مایع داخل عروقی
                                                                                            • محلولهای وریدی
                                                                                            • Fluids
                                                                                            • Slide 33
                                                                                            • Slide 34
                                                                                            • Slide 35
                                                                                            • Crystalloids
                                                                                            • Colloid Solutions
                                                                                            • رینگر لاکتات
                                                                                            • 09Nacl
                                                                                            • Postoperative (maintenance)
                                                                                            • Slide 41
                                                                                            • Preexisting fluid deficits
                                                                                            • Maintenance requirements
                                                                                            • Surgical fluid losses
                                                                                            • Third space loss
                                                                                            • Crystalloid solution
                                                                                            • Colloids
                                                                                            • Complications
                                                                                            • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                            • Colloid versus crystalloid solutions
                                                                                            • Transfusion consideration
                                                                                            • اختلال در حجم مایعات بدن
                                                                                            • Fluid volume deficit (FVD)
                                                                                            • DEHYDRATION
                                                                                            • علل کاهش حجم خارج سلولی
                                                                                            • Signs of Hypovolemia
                                                                                            • Clinical Diagnosis of Hypovolemia
                                                                                            • Signs of Hypervolemia
                                                                                            • Management of Hypervolemia
                                                                                            • Fluid Management
                                                                                            • Electrolyte physiology
                                                                                            • Sodium physiology
                                                                                            • Osmotic Pressure
                                                                                            • Concentration
                                                                                            • Hypernatremia
                                                                                            • - Hypernatremia
                                                                                            • Slide 67
                                                                                            • Slide 68
                                                                                            • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                            • Treatment
                                                                                            • Water deficit (L)= times TBW
                                                                                            • The rate of fluid administration
                                                                                            • Hyponatremia Nalt135mEqL
                                                                                            • Slide 74
                                                                                            • Sodium depletion
                                                                                            • Sodium dilution
                                                                                            • Sign and symptoms
                                                                                            • Slide 78
                                                                                            • Treatment
                                                                                            • Slide 80
                                                                                            • Slide 81
                                                                                            • Dose
                                                                                            • Potassium abnormalities
                                                                                            • Hyperkalemia
                                                                                            • Clinical manifestation of hyperkalemia
                                                                                            • Slide 86
                                                                                            • Slide 87
                                                                                            • Hypokalemia
                                                                                            • Potassium changes associated with alkalosis
                                                                                            • Slide 90
                                                                                            • Clinical Manifestation of Abnormalities in potassium
                                                                                            • Slide 92
                                                                                            • Calcium
                                                                                            • هيپوكلسمي یونیزه Calt45 meql
                                                                                            • علائم هیپوکلسمی
                                                                                            • Slide 96
                                                                                            • Slide 97
                                                                                            • Slide 98
                                                                                            • Slide 99
                                                                                            • سایرعلائم
                                                                                            • درمان
                                                                                            • هيپركلسمي Cagt55meql
                                                                                            • علائم
                                                                                            • علائم قلبی
                                                                                            • Slide 105
                                                                                            • Magnesium Abnormalities
                                                                                            • منیزیوم
                                                                                            • Hypermagnesemia
                                                                                            • Clinical manifestation hypermanesemia
                                                                                            • Slide 110
                                                                                            • Slide 111
                                                                                            • Hypomagnesemia
                                                                                            • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                            • Slide 114
                                                                                            • Message for Today
                                                                                            • Slide 116

                                                                                              Complications 1 Hypersensitivity reactions (anaphylaxis )2 Pruritis (hetastarch)3 Couglopathy (dextran 70 and hetastarch) gt 1 litter bull Dextran ( platelet aggregation adhesive)bull Hetastarch (reduction in factor vlll and VOB

                                                                                              factor )These colloid is best avoided in patients with

                                                                                              coagulopaty

                                                                                              The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                                                              1000cc

                                                                                              500cc

                                                                                              500cc

                                                                                              500cc

                                                                                              200

                                                                                              600

                                                                                              1000

                                                                                              Lactated Ringers

                                                                                              5 Albumin

                                                                                              6 Hetastarch

                                                                                              Whole blood

                                                                                              Blood volumeInfusion volume

                                                                                              Colloid versus crystalloid solutions

                                                                                              Transfusion consideration

                                                                                              bull HB lt7 mg dl increase CO

                                                                                              bull Ideal Hb is 7-8 mgdl

                                                                                              bull In IHD patients or pulmonary disease gt 10 mgdl

                                                                                              بدن مایعات حجم در اختالل

                                                                                              1 Fluid volume deficit

                                                                                              2 Fluid volume excess

                                                                                              Fluid volume deficit(FVD)

                                                                                              ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                                              کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                                              ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                                              باشد آن با همراه دیگری اختالل مگر

                                                                                              DEHYDRATION

                                                                                              سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                                              سلولی خارج حجم کاهش علل

                                                                                              1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                                              2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                                              کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                                              Signs of HypovolemiaSigns of Hypovolemia

                                                                                              bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                                              Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                                              bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                                              Signs of HypervolemiaSigns of Hypervolemia

                                                                                              bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                                              Especially when hypo-albuminemia

                                                                                              Management of Management of HypervolemiaHypervolemia

                                                                                              bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                                              Fluid ManagementFluid Management

                                                                                              bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                              Electrolyte physiology

                                                                                              Sodium physiology

                                                                                              Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                              Normal amount 135-145 meql

                                                                                              Osmotic Pressure

                                                                                              Calculated serum osmolality =

                                                                                              2 sodium+ glucose18 + BUN 28

                                                                                              Osmolality = 290 mosm

                                                                                              Concentration

                                                                                              1Serum sodium concentration2Serum osmolarity

                                                                                              bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                              drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                              DW5)

                                                                                              Hypernatremia

                                                                                              Serum Nagt145mEqL

                                                                                              - Hypernatremia

                                                                                              Loss of Free Water

                                                                                              Gain of sodium in excess of water

                                                                                              Hypernatremia

                                                                                              -Hypernatremia Hypo volemic

                                                                                              Hyper volemic

                                                                                              Normo volemic

                                                                                              Hypernatremia

                                                                                              Volume Status

                                                                                              Normal

                                                                                              Nonrenal water loss

                                                                                              Skin

                                                                                              Gastrointestinal

                                                                                              Renal water loss

                                                                                              Renal disease

                                                                                              Diuretics

                                                                                              Diabetes insipidus

                                                                                              High

                                                                                              Iatrogenic sodium administration

                                                                                              Mineralocorticoid excess

                                                                                              Aldosteronism

                                                                                              Cushingrsquos disease

                                                                                              Congenital adrenal

                                                                                              hyperplasia

                                                                                              Low

                                                                                              Nonrenal water loss

                                                                                              Skin

                                                                                              Gastrointestinal losses

                                                                                              Renal water losses

                                                                                              Renal (tubular) Diuretics

                                                                                              Osmotic diuretics

                                                                                              Diabetes insipidus

                                                                                              Adrenal failure

                                                                                              Asymptomatic

                                                                                              Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                              Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                              Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                              Body system hypernatremia

                                                                                              Treatment

                                                                                              Normal saline in hypovolemic patients

                                                                                              Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                              saline or entral water)

                                                                                              Water deficit (L)= times TBW

                                                                                              The formula used to estimate the amount of water required to correct hypernatremia

                                                                                              Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                              Serum sodium-140

                                                                                              140

                                                                                              The rate of fluid administration

                                                                                              1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                              2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                              Hyponatremia Nalt135mEqL

                                                                                              Causes

                                                                                              1 Sodium depletion

                                                                                              2 Sodium dilution

                                                                                              bull Incidence = 45

                                                                                              bull After surgery=1

                                                                                              bull Mortality = 2 times normal

                                                                                              Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                              volume deficit

                                                                                              Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                              Sign and symptoms

                                                                                              bull CNS symptom when Nalt123 meql

                                                                                              bull Cardiac symptom when Nalt100 meql

                                                                                              For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                              Body System Hyponatremia

                                                                                              central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                              reflexes seizures coma increased intracranial pressure

                                                                                              Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                              Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                              Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                              intracranial pressure

                                                                                              Tissue Lacrimation salivation

                                                                                              Renal Oliguria

                                                                                              Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                              Treatment

                                                                                              1=Depend on ECF

                                                                                              2=CNS sign

                                                                                              Treatment

                                                                                              1 Asymptomatic increase the sodium level by no more than

                                                                                              05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                              2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                              more than 1meqL per hour until the serum Na level reaches 130

                                                                                              meqL or neurologic symptoms are improved

                                                                                              Rapid correction of hyponatremia

                                                                                              Pontine myelinolysis

                                                                                              Seizures weaknessparesis akinetic

                                                                                              movements unresponsiveness

                                                                                              Permanent brain damage

                                                                                              Death

                                                                                              Dose

                                                                                              Na deficit meq =(140- Na meql) TBW

                                                                                              باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                              شود اصالح آهسته سپس

                                                                                              Potassium abnormalities

                                                                                              bull The average dietary intake of potassium 50-100meqd

                                                                                              bull The average renal excretion of potassium 10-700 meqd

                                                                                              - 2 of the total body potassium in ECF (45meqL)

                                                                                              - Factors that influence serum potassium

                                                                                              1 Surgical stress

                                                                                              2 Injury

                                                                                              3 Acidosis

                                                                                              4 Tissue catabolism

                                                                                              Hyperkalemia

                                                                                              The normal range of serum potassium 35-5 meqL

                                                                                              Etiology of Hyperkalemia

                                                                                              Increased intake Potassium supplementation

                                                                                              Blood transfusions

                                                                                              Endogenous loaddestruction

                                                                                              hemolysis rhabdomyolysis

                                                                                              cruch injury gastrointestinal hemorrhage

                                                                                              Increased release Acidosis

                                                                                              Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                              Renal insufficiencyfailure

                                                                                              Clinical manifestation of hyperkalemia

                                                                                              System hyperkalemia

                                                                                              Gastrointestinal Nauseavomiting colic diarrhea

                                                                                              Neuromuscular weakness paralysis respiratory failure

                                                                                              Cardiovascular Arrhythmia arrest

                                                                                              ECG changes Peaked T waves (early change)

                                                                                              Flattened P wave

                                                                                              Prolonged PR interval (first-degree block)

                                                                                              Widened QRS complex

                                                                                              Sine wave formation

                                                                                              Ventricular fibrillation

                                                                                              Treatment

                                                                                              Treatment of symptomatic hyperkalemia

                                                                                              Potassium removal Kayexalate

                                                                                              Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                              Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                              Dialysis

                                                                                              Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                              Bicarbonate 1 vial intravenous

                                                                                              Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                              HypokalemiaEtiology

                                                                                              inadequate intake

                                                                                              Dietary potassium-free intravenous fluids potassium-deficient

                                                                                              total parenteral nutrition

                                                                                              Excessive potassium excretion

                                                                                              Hyperaldosteronism

                                                                                              Medications

                                                                                              Gastrointestinal losses

                                                                                              Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                              Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                              nasogastric output)

                                                                                              Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                              Potassium changes associated with alkalosis

                                                                                              Potassium decrease by 03 meqL for every 01

                                                                                              increase in PH above normal

                                                                                              Magnesium Depletion

                                                                                              (drug induced amphotericin amioglycosides cisplatin)

                                                                                              Renal potassium wastage

                                                                                              Hypokalemia

                                                                                              Magnesium Depletion

                                                                                              (drug induced amphotericin amioglycosides cisplatin)

                                                                                              Renal potassium wastage

                                                                                              Hypokalemia

                                                                                              Clinical Manifestation of Abnormalities in potassium

                                                                                              System hypokalemia

                                                                                              Gastrointestinal Ileus constipation

                                                                                              Neuromuscular Decreased reflexes fatigue weakness

                                                                                              paralysis

                                                                                              Cardiovascular Arrest

                                                                                              ECG changes U-waves

                                                                                              T-wave flattening

                                                                                              ST-segment changes

                                                                                              Arrhythmias

                                                                                              Treatment

                                                                                              Potassium

                                                                                              Serum potassium level lt40 mEqL

                                                                                              Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                              times 1 doses

                                                                                              Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                              Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                              Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                              asymptomatic replace as per above protocol

                                                                                              Electrolyte Replacement Therapy Protocol

                                                                                              bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                              bull IV repletion for severe and symptomatic hypokalemia

                                                                                              Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                              ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                              عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                              صاف 2 عضالت انقباض

                                                                                              هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                              انعقاد 4

                                                                                              یونیزه Calt45 meql هيپوكلسمي

                                                                                              عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                              ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                              میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                              ( شود می پیوند شده

                                                                                              هیپوکلسمی عالئم

                                                                                              رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                              سایرعالئم

                                                                                              قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                              درمان

                                                                                              ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                              Cagt55meql هيپركلسمي

                                                                                              هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                              عالئم

                                                                                              bullGI

                                                                                              bullCardiovascular bullRenal (polyuria)

                                                                                              bullCNS

                                                                                              قلبی عالئم

                                                                                              bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                              QRS شدن )Q-Tوكوتاه

                                                                                              درمان

                                                                                              ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                              الزیکس2

                                                                                              تونین 3 کلسی

                                                                                              کورتون4

                                                                                              دیالیز5

                                                                                              Magnesium Abnormalities

                                                                                              Normal dietary intake 20meq (240mg)

                                                                                              Excretion in both the feces and urine

                                                                                              Normal serum level 19-25 mgdL

                                                                                              منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                              تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                              bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                              Hypermagnesemia

                                                                                              Etiology

                                                                                              1 Impaired renal function

                                                                                              2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                              Clinical manifestation hypermanesemia

                                                                                              System hypermanesemia

                                                                                              Gastrointestinal Nauseavomiting

                                                                                              Neuromuscular weakness lethargy Decreased

                                                                                              reflexes

                                                                                              Cardiovascular Hypotension arrest

                                                                                              ECG changes Increased PR interval

                                                                                              Widened QRS complex

                                                                                              Elevated T waves

                                                                                              Treatment

                                                                                              1 Withhold exogenous sources of magnesium

                                                                                              2 Correct volume deficit

                                                                                              3 Correct acidosis if present

                                                                                              4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                              5 Dialysis (if elevated levels or symptoms persist)

                                                                                              عالئم

                                                                                              bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                              meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                              meqL

                                                                                              Hypomagnesemia

                                                                                              Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                              homeostasis

                                                                                              Etiology

                                                                                              1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                              inadequate supplementation of magnesium)

                                                                                              2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                              3 GI losses (diarrhea)

                                                                                              4 Malabsorption

                                                                                              5 Acute pancreatitis

                                                                                              6 Diabetic ketoacidosis

                                                                                              7 Primary aldosteronism

                                                                                              Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                              1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                              2 Delirium and seizures in severe deficiency

                                                                                              3 ECG changes Prolonged QT and PR interval

                                                                                              ST-segment depression

                                                                                              Flattening or inversion of P waves

                                                                                              Torsades de pointes

                                                                                              Arrhythmia

                                                                                              Treatment

                                                                                              1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                              2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                              Message for Today

                                                                                              ICF

                                                                                              Interstitial

                                                                                              Pla

                                                                                              sma

                                                                                              5 Dex

                                                                                              bull Do not reccussitate sick patients with any Dextrose solution

                                                                                              • Fluid and Electrolyte Management of the Surgical Patient
                                                                                              • Slide 2
                                                                                              • Slide 3
                                                                                              • Slide 4
                                                                                              • Total Body Water
                                                                                              • Body Fluid Compartments
                                                                                              • Total body water (TBW)
                                                                                              • Body compartment fluid
                                                                                              • Example men with 70kg
                                                                                              • Fluid compartments
                                                                                              • Slide 11
                                                                                              • Slide 12
                                                                                              • Slide 13
                                                                                              • Slide 14
                                                                                              • Slide 15
                                                                                              • Colloid osmotic pressure
                                                                                              • Slide 17
                                                                                              • Slide 18
                                                                                              • Slide 19
                                                                                              • Cell Membrane
                                                                                              • Slide 21
                                                                                              • Slide 22
                                                                                              • Slide 23
                                                                                              • Slide 24
                                                                                              • Slide 25
                                                                                              • Composition of Fluid Compartments
                                                                                              • Composition of Body Fluids
                                                                                              • عوامل موثر روی تغییرات آب والکترولیت
                                                                                              • Reasons for fluid therapy
                                                                                              • ارزیابی حجم مایع داخل عروقی
                                                                                              • محلولهای وریدی
                                                                                              • Fluids
                                                                                              • Slide 33
                                                                                              • Slide 34
                                                                                              • Slide 35
                                                                                              • Crystalloids
                                                                                              • Colloid Solutions
                                                                                              • رینگر لاکتات
                                                                                              • 09Nacl
                                                                                              • Postoperative (maintenance)
                                                                                              • Slide 41
                                                                                              • Preexisting fluid deficits
                                                                                              • Maintenance requirements
                                                                                              • Surgical fluid losses
                                                                                              • Third space loss
                                                                                              • Crystalloid solution
                                                                                              • Colloids
                                                                                              • Complications
                                                                                              • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                              • Colloid versus crystalloid solutions
                                                                                              • Transfusion consideration
                                                                                              • اختلال در حجم مایعات بدن
                                                                                              • Fluid volume deficit (FVD)
                                                                                              • DEHYDRATION
                                                                                              • علل کاهش حجم خارج سلولی
                                                                                              • Signs of Hypovolemia
                                                                                              • Clinical Diagnosis of Hypovolemia
                                                                                              • Signs of Hypervolemia
                                                                                              • Management of Hypervolemia
                                                                                              • Fluid Management
                                                                                              • Electrolyte physiology
                                                                                              • Sodium physiology
                                                                                              • Osmotic Pressure
                                                                                              • Concentration
                                                                                              • Hypernatremia
                                                                                              • - Hypernatremia
                                                                                              • Slide 67
                                                                                              • Slide 68
                                                                                              • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                              • Treatment
                                                                                              • Water deficit (L)= times TBW
                                                                                              • The rate of fluid administration
                                                                                              • Hyponatremia Nalt135mEqL
                                                                                              • Slide 74
                                                                                              • Sodium depletion
                                                                                              • Sodium dilution
                                                                                              • Sign and symptoms
                                                                                              • Slide 78
                                                                                              • Treatment
                                                                                              • Slide 80
                                                                                              • Slide 81
                                                                                              • Dose
                                                                                              • Potassium abnormalities
                                                                                              • Hyperkalemia
                                                                                              • Clinical manifestation of hyperkalemia
                                                                                              • Slide 86
                                                                                              • Slide 87
                                                                                              • Hypokalemia
                                                                                              • Potassium changes associated with alkalosis
                                                                                              • Slide 90
                                                                                              • Clinical Manifestation of Abnormalities in potassium
                                                                                              • Slide 92
                                                                                              • Calcium
                                                                                              • هيپوكلسمي یونیزه Calt45 meql
                                                                                              • علائم هیپوکلسمی
                                                                                              • Slide 96
                                                                                              • Slide 97
                                                                                              • Slide 98
                                                                                              • Slide 99
                                                                                              • سایرعلائم
                                                                                              • درمان
                                                                                              • هيپركلسمي Cagt55meql
                                                                                              • علائم
                                                                                              • علائم قلبی
                                                                                              • Slide 105
                                                                                              • Magnesium Abnormalities
                                                                                              • منیزیوم
                                                                                              • Hypermagnesemia
                                                                                              • Clinical manifestation hypermanesemia
                                                                                              • Slide 110
                                                                                              • Slide 111
                                                                                              • Hypomagnesemia
                                                                                              • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                              • Slide 114
                                                                                              • Message for Today
                                                                                              • Slide 116

                                                                                                The Influence of Colloid amp Crystalloid The Influence of Colloid amp Crystalloid on Blood Volumeon Blood Volume

                                                                                                1000cc

                                                                                                500cc

                                                                                                500cc

                                                                                                500cc

                                                                                                200

                                                                                                600

                                                                                                1000

                                                                                                Lactated Ringers

                                                                                                5 Albumin

                                                                                                6 Hetastarch

                                                                                                Whole blood

                                                                                                Blood volumeInfusion volume

                                                                                                Colloid versus crystalloid solutions

                                                                                                Transfusion consideration

                                                                                                bull HB lt7 mg dl increase CO

                                                                                                bull Ideal Hb is 7-8 mgdl

                                                                                                bull In IHD patients or pulmonary disease gt 10 mgdl

                                                                                                بدن مایعات حجم در اختالل

                                                                                                1 Fluid volume deficit

                                                                                                2 Fluid volume excess

                                                                                                Fluid volume deficit(FVD)

                                                                                                ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                                                کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                                                ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                                                باشد آن با همراه دیگری اختالل مگر

                                                                                                DEHYDRATION

                                                                                                سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                                                سلولی خارج حجم کاهش علل

                                                                                                1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                                                2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                                                کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                                                Signs of HypovolemiaSigns of Hypovolemia

                                                                                                bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                                                Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                                                bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                                                Signs of HypervolemiaSigns of Hypervolemia

                                                                                                bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                                                Especially when hypo-albuminemia

                                                                                                Management of Management of HypervolemiaHypervolemia

                                                                                                bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                                                Fluid ManagementFluid Management

                                                                                                bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                                Electrolyte physiology

                                                                                                Sodium physiology

                                                                                                Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                                Normal amount 135-145 meql

                                                                                                Osmotic Pressure

                                                                                                Calculated serum osmolality =

                                                                                                2 sodium+ glucose18 + BUN 28

                                                                                                Osmolality = 290 mosm

                                                                                                Concentration

                                                                                                1Serum sodium concentration2Serum osmolarity

                                                                                                bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                                drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                                DW5)

                                                                                                Hypernatremia

                                                                                                Serum Nagt145mEqL

                                                                                                - Hypernatremia

                                                                                                Loss of Free Water

                                                                                                Gain of sodium in excess of water

                                                                                                Hypernatremia

                                                                                                -Hypernatremia Hypo volemic

                                                                                                Hyper volemic

                                                                                                Normo volemic

                                                                                                Hypernatremia

                                                                                                Volume Status

                                                                                                Normal

                                                                                                Nonrenal water loss

                                                                                                Skin

                                                                                                Gastrointestinal

                                                                                                Renal water loss

                                                                                                Renal disease

                                                                                                Diuretics

                                                                                                Diabetes insipidus

                                                                                                High

                                                                                                Iatrogenic sodium administration

                                                                                                Mineralocorticoid excess

                                                                                                Aldosteronism

                                                                                                Cushingrsquos disease

                                                                                                Congenital adrenal

                                                                                                hyperplasia

                                                                                                Low

                                                                                                Nonrenal water loss

                                                                                                Skin

                                                                                                Gastrointestinal losses

                                                                                                Renal water losses

                                                                                                Renal (tubular) Diuretics

                                                                                                Osmotic diuretics

                                                                                                Diabetes insipidus

                                                                                                Adrenal failure

                                                                                                Asymptomatic

                                                                                                Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                Body system hypernatremia

                                                                                                Treatment

                                                                                                Normal saline in hypovolemic patients

                                                                                                Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                saline or entral water)

                                                                                                Water deficit (L)= times TBW

                                                                                                The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                Serum sodium-140

                                                                                                140

                                                                                                The rate of fluid administration

                                                                                                1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                Hyponatremia Nalt135mEqL

                                                                                                Causes

                                                                                                1 Sodium depletion

                                                                                                2 Sodium dilution

                                                                                                bull Incidence = 45

                                                                                                bull After surgery=1

                                                                                                bull Mortality = 2 times normal

                                                                                                Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                volume deficit

                                                                                                Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                Sign and symptoms

                                                                                                bull CNS symptom when Nalt123 meql

                                                                                                bull Cardiac symptom when Nalt100 meql

                                                                                                For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                Body System Hyponatremia

                                                                                                central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                reflexes seizures coma increased intracranial pressure

                                                                                                Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                intracranial pressure

                                                                                                Tissue Lacrimation salivation

                                                                                                Renal Oliguria

                                                                                                Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                Treatment

                                                                                                1=Depend on ECF

                                                                                                2=CNS sign

                                                                                                Treatment

                                                                                                1 Asymptomatic increase the sodium level by no more than

                                                                                                05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                more than 1meqL per hour until the serum Na level reaches 130

                                                                                                meqL or neurologic symptoms are improved

                                                                                                Rapid correction of hyponatremia

                                                                                                Pontine myelinolysis

                                                                                                Seizures weaknessparesis akinetic

                                                                                                movements unresponsiveness

                                                                                                Permanent brain damage

                                                                                                Death

                                                                                                Dose

                                                                                                Na deficit meq =(140- Na meql) TBW

                                                                                                باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                شود اصالح آهسته سپس

                                                                                                Potassium abnormalities

                                                                                                bull The average dietary intake of potassium 50-100meqd

                                                                                                bull The average renal excretion of potassium 10-700 meqd

                                                                                                - 2 of the total body potassium in ECF (45meqL)

                                                                                                - Factors that influence serum potassium

                                                                                                1 Surgical stress

                                                                                                2 Injury

                                                                                                3 Acidosis

                                                                                                4 Tissue catabolism

                                                                                                Hyperkalemia

                                                                                                The normal range of serum potassium 35-5 meqL

                                                                                                Etiology of Hyperkalemia

                                                                                                Increased intake Potassium supplementation

                                                                                                Blood transfusions

                                                                                                Endogenous loaddestruction

                                                                                                hemolysis rhabdomyolysis

                                                                                                cruch injury gastrointestinal hemorrhage

                                                                                                Increased release Acidosis

                                                                                                Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                Renal insufficiencyfailure

                                                                                                Clinical manifestation of hyperkalemia

                                                                                                System hyperkalemia

                                                                                                Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                Neuromuscular weakness paralysis respiratory failure

                                                                                                Cardiovascular Arrhythmia arrest

                                                                                                ECG changes Peaked T waves (early change)

                                                                                                Flattened P wave

                                                                                                Prolonged PR interval (first-degree block)

                                                                                                Widened QRS complex

                                                                                                Sine wave formation

                                                                                                Ventricular fibrillation

                                                                                                Treatment

                                                                                                Treatment of symptomatic hyperkalemia

                                                                                                Potassium removal Kayexalate

                                                                                                Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                Dialysis

                                                                                                Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                Bicarbonate 1 vial intravenous

                                                                                                Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                HypokalemiaEtiology

                                                                                                inadequate intake

                                                                                                Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                total parenteral nutrition

                                                                                                Excessive potassium excretion

                                                                                                Hyperaldosteronism

                                                                                                Medications

                                                                                                Gastrointestinal losses

                                                                                                Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                nasogastric output)

                                                                                                Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                Potassium changes associated with alkalosis

                                                                                                Potassium decrease by 03 meqL for every 01

                                                                                                increase in PH above normal

                                                                                                Magnesium Depletion

                                                                                                (drug induced amphotericin amioglycosides cisplatin)

                                                                                                Renal potassium wastage

                                                                                                Hypokalemia

                                                                                                Magnesium Depletion

                                                                                                (drug induced amphotericin amioglycosides cisplatin)

                                                                                                Renal potassium wastage

                                                                                                Hypokalemia

                                                                                                Clinical Manifestation of Abnormalities in potassium

                                                                                                System hypokalemia

                                                                                                Gastrointestinal Ileus constipation

                                                                                                Neuromuscular Decreased reflexes fatigue weakness

                                                                                                paralysis

                                                                                                Cardiovascular Arrest

                                                                                                ECG changes U-waves

                                                                                                T-wave flattening

                                                                                                ST-segment changes

                                                                                                Arrhythmias

                                                                                                Treatment

                                                                                                Potassium

                                                                                                Serum potassium level lt40 mEqL

                                                                                                Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                times 1 doses

                                                                                                Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                asymptomatic replace as per above protocol

                                                                                                Electrolyte Replacement Therapy Protocol

                                                                                                bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                bull IV repletion for severe and symptomatic hypokalemia

                                                                                                Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                صاف 2 عضالت انقباض

                                                                                                هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                انعقاد 4

                                                                                                یونیزه Calt45 meql هيپوكلسمي

                                                                                                عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                ( شود می پیوند شده

                                                                                                هیپوکلسمی عالئم

                                                                                                رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                سایرعالئم

                                                                                                قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                درمان

                                                                                                ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                Cagt55meql هيپركلسمي

                                                                                                هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                عالئم

                                                                                                bullGI

                                                                                                bullCardiovascular bullRenal (polyuria)

                                                                                                bullCNS

                                                                                                قلبی عالئم

                                                                                                bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                QRS شدن )Q-Tوكوتاه

                                                                                                درمان

                                                                                                ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                الزیکس2

                                                                                                تونین 3 کلسی

                                                                                                کورتون4

                                                                                                دیالیز5

                                                                                                Magnesium Abnormalities

                                                                                                Normal dietary intake 20meq (240mg)

                                                                                                Excretion in both the feces and urine

                                                                                                Normal serum level 19-25 mgdL

                                                                                                منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                Hypermagnesemia

                                                                                                Etiology

                                                                                                1 Impaired renal function

                                                                                                2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                Clinical manifestation hypermanesemia

                                                                                                System hypermanesemia

                                                                                                Gastrointestinal Nauseavomiting

                                                                                                Neuromuscular weakness lethargy Decreased

                                                                                                reflexes

                                                                                                Cardiovascular Hypotension arrest

                                                                                                ECG changes Increased PR interval

                                                                                                Widened QRS complex

                                                                                                Elevated T waves

                                                                                                Treatment

                                                                                                1 Withhold exogenous sources of magnesium

                                                                                                2 Correct volume deficit

                                                                                                3 Correct acidosis if present

                                                                                                4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                5 Dialysis (if elevated levels or symptoms persist)

                                                                                                عالئم

                                                                                                bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                meqL

                                                                                                Hypomagnesemia

                                                                                                Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                homeostasis

                                                                                                Etiology

                                                                                                1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                inadequate supplementation of magnesium)

                                                                                                2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                3 GI losses (diarrhea)

                                                                                                4 Malabsorption

                                                                                                5 Acute pancreatitis

                                                                                                6 Diabetic ketoacidosis

                                                                                                7 Primary aldosteronism

                                                                                                Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                2 Delirium and seizures in severe deficiency

                                                                                                3 ECG changes Prolonged QT and PR interval

                                                                                                ST-segment depression

                                                                                                Flattening or inversion of P waves

                                                                                                Torsades de pointes

                                                                                                Arrhythmia

                                                                                                Treatment

                                                                                                1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                Message for Today

                                                                                                ICF

                                                                                                Interstitial

                                                                                                Pla

                                                                                                sma

                                                                                                5 Dex

                                                                                                bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                • Slide 2
                                                                                                • Slide 3
                                                                                                • Slide 4
                                                                                                • Total Body Water
                                                                                                • Body Fluid Compartments
                                                                                                • Total body water (TBW)
                                                                                                • Body compartment fluid
                                                                                                • Example men with 70kg
                                                                                                • Fluid compartments
                                                                                                • Slide 11
                                                                                                • Slide 12
                                                                                                • Slide 13
                                                                                                • Slide 14
                                                                                                • Slide 15
                                                                                                • Colloid osmotic pressure
                                                                                                • Slide 17
                                                                                                • Slide 18
                                                                                                • Slide 19
                                                                                                • Cell Membrane
                                                                                                • Slide 21
                                                                                                • Slide 22
                                                                                                • Slide 23
                                                                                                • Slide 24
                                                                                                • Slide 25
                                                                                                • Composition of Fluid Compartments
                                                                                                • Composition of Body Fluids
                                                                                                • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                • Reasons for fluid therapy
                                                                                                • ارزیابی حجم مایع داخل عروقی
                                                                                                • محلولهای وریدی
                                                                                                • Fluids
                                                                                                • Slide 33
                                                                                                • Slide 34
                                                                                                • Slide 35
                                                                                                • Crystalloids
                                                                                                • Colloid Solutions
                                                                                                • رینگر لاکتات
                                                                                                • 09Nacl
                                                                                                • Postoperative (maintenance)
                                                                                                • Slide 41
                                                                                                • Preexisting fluid deficits
                                                                                                • Maintenance requirements
                                                                                                • Surgical fluid losses
                                                                                                • Third space loss
                                                                                                • Crystalloid solution
                                                                                                • Colloids
                                                                                                • Complications
                                                                                                • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                • Colloid versus crystalloid solutions
                                                                                                • Transfusion consideration
                                                                                                • اختلال در حجم مایعات بدن
                                                                                                • Fluid volume deficit (FVD)
                                                                                                • DEHYDRATION
                                                                                                • علل کاهش حجم خارج سلولی
                                                                                                • Signs of Hypovolemia
                                                                                                • Clinical Diagnosis of Hypovolemia
                                                                                                • Signs of Hypervolemia
                                                                                                • Management of Hypervolemia
                                                                                                • Fluid Management
                                                                                                • Electrolyte physiology
                                                                                                • Sodium physiology
                                                                                                • Osmotic Pressure
                                                                                                • Concentration
                                                                                                • Hypernatremia
                                                                                                • - Hypernatremia
                                                                                                • Slide 67
                                                                                                • Slide 68
                                                                                                • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                • Treatment
                                                                                                • Water deficit (L)= times TBW
                                                                                                • The rate of fluid administration
                                                                                                • Hyponatremia Nalt135mEqL
                                                                                                • Slide 74
                                                                                                • Sodium depletion
                                                                                                • Sodium dilution
                                                                                                • Sign and symptoms
                                                                                                • Slide 78
                                                                                                • Treatment
                                                                                                • Slide 80
                                                                                                • Slide 81
                                                                                                • Dose
                                                                                                • Potassium abnormalities
                                                                                                • Hyperkalemia
                                                                                                • Clinical manifestation of hyperkalemia
                                                                                                • Slide 86
                                                                                                • Slide 87
                                                                                                • Hypokalemia
                                                                                                • Potassium changes associated with alkalosis
                                                                                                • Slide 90
                                                                                                • Clinical Manifestation of Abnormalities in potassium
                                                                                                • Slide 92
                                                                                                • Calcium
                                                                                                • هيپوكلسمي یونیزه Calt45 meql
                                                                                                • علائم هیپوکلسمی
                                                                                                • Slide 96
                                                                                                • Slide 97
                                                                                                • Slide 98
                                                                                                • Slide 99
                                                                                                • سایرعلائم
                                                                                                • درمان
                                                                                                • هيپركلسمي Cagt55meql
                                                                                                • علائم
                                                                                                • علائم قلبی
                                                                                                • Slide 105
                                                                                                • Magnesium Abnormalities
                                                                                                • منیزیوم
                                                                                                • Hypermagnesemia
                                                                                                • Clinical manifestation hypermanesemia
                                                                                                • Slide 110
                                                                                                • Slide 111
                                                                                                • Hypomagnesemia
                                                                                                • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                • Slide 114
                                                                                                • Message for Today
                                                                                                • Slide 116

                                                                                                  Colloid versus crystalloid solutions

                                                                                                  Transfusion consideration

                                                                                                  bull HB lt7 mg dl increase CO

                                                                                                  bull Ideal Hb is 7-8 mgdl

                                                                                                  bull In IHD patients or pulmonary disease gt 10 mgdl

                                                                                                  بدن مایعات حجم در اختالل

                                                                                                  1 Fluid volume deficit

                                                                                                  2 Fluid volume excess

                                                                                                  Fluid volume deficit(FVD)

                                                                                                  ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                                                  کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                                                  ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                                                  باشد آن با همراه دیگری اختالل مگر

                                                                                                  DEHYDRATION

                                                                                                  سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                                                  سلولی خارج حجم کاهش علل

                                                                                                  1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                                                  2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                                                  کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                                                  Signs of HypovolemiaSigns of Hypovolemia

                                                                                                  bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                                                  Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                                                  bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                                                  Signs of HypervolemiaSigns of Hypervolemia

                                                                                                  bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                                                  Especially when hypo-albuminemia

                                                                                                  Management of Management of HypervolemiaHypervolemia

                                                                                                  bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                                                  Fluid ManagementFluid Management

                                                                                                  bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                                  Electrolyte physiology

                                                                                                  Sodium physiology

                                                                                                  Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                                  Normal amount 135-145 meql

                                                                                                  Osmotic Pressure

                                                                                                  Calculated serum osmolality =

                                                                                                  2 sodium+ glucose18 + BUN 28

                                                                                                  Osmolality = 290 mosm

                                                                                                  Concentration

                                                                                                  1Serum sodium concentration2Serum osmolarity

                                                                                                  bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                                  drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                                  DW5)

                                                                                                  Hypernatremia

                                                                                                  Serum Nagt145mEqL

                                                                                                  - Hypernatremia

                                                                                                  Loss of Free Water

                                                                                                  Gain of sodium in excess of water

                                                                                                  Hypernatremia

                                                                                                  -Hypernatremia Hypo volemic

                                                                                                  Hyper volemic

                                                                                                  Normo volemic

                                                                                                  Hypernatremia

                                                                                                  Volume Status

                                                                                                  Normal

                                                                                                  Nonrenal water loss

                                                                                                  Skin

                                                                                                  Gastrointestinal

                                                                                                  Renal water loss

                                                                                                  Renal disease

                                                                                                  Diuretics

                                                                                                  Diabetes insipidus

                                                                                                  High

                                                                                                  Iatrogenic sodium administration

                                                                                                  Mineralocorticoid excess

                                                                                                  Aldosteronism

                                                                                                  Cushingrsquos disease

                                                                                                  Congenital adrenal

                                                                                                  hyperplasia

                                                                                                  Low

                                                                                                  Nonrenal water loss

                                                                                                  Skin

                                                                                                  Gastrointestinal losses

                                                                                                  Renal water losses

                                                                                                  Renal (tubular) Diuretics

                                                                                                  Osmotic diuretics

                                                                                                  Diabetes insipidus

                                                                                                  Adrenal failure

                                                                                                  Asymptomatic

                                                                                                  Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                  Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                  Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                  Body system hypernatremia

                                                                                                  Treatment

                                                                                                  Normal saline in hypovolemic patients

                                                                                                  Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                  saline or entral water)

                                                                                                  Water deficit (L)= times TBW

                                                                                                  The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                  Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                  Serum sodium-140

                                                                                                  140

                                                                                                  The rate of fluid administration

                                                                                                  1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                  2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                  Hyponatremia Nalt135mEqL

                                                                                                  Causes

                                                                                                  1 Sodium depletion

                                                                                                  2 Sodium dilution

                                                                                                  bull Incidence = 45

                                                                                                  bull After surgery=1

                                                                                                  bull Mortality = 2 times normal

                                                                                                  Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                  volume deficit

                                                                                                  Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                  Sign and symptoms

                                                                                                  bull CNS symptom when Nalt123 meql

                                                                                                  bull Cardiac symptom when Nalt100 meql

                                                                                                  For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                  Body System Hyponatremia

                                                                                                  central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                  reflexes seizures coma increased intracranial pressure

                                                                                                  Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                  Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                  Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                  intracranial pressure

                                                                                                  Tissue Lacrimation salivation

                                                                                                  Renal Oliguria

                                                                                                  Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                  Treatment

                                                                                                  1=Depend on ECF

                                                                                                  2=CNS sign

                                                                                                  Treatment

                                                                                                  1 Asymptomatic increase the sodium level by no more than

                                                                                                  05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                  2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                  more than 1meqL per hour until the serum Na level reaches 130

                                                                                                  meqL or neurologic symptoms are improved

                                                                                                  Rapid correction of hyponatremia

                                                                                                  Pontine myelinolysis

                                                                                                  Seizures weaknessparesis akinetic

                                                                                                  movements unresponsiveness

                                                                                                  Permanent brain damage

                                                                                                  Death

                                                                                                  Dose

                                                                                                  Na deficit meq =(140- Na meql) TBW

                                                                                                  باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                  شود اصالح آهسته سپس

                                                                                                  Potassium abnormalities

                                                                                                  bull The average dietary intake of potassium 50-100meqd

                                                                                                  bull The average renal excretion of potassium 10-700 meqd

                                                                                                  - 2 of the total body potassium in ECF (45meqL)

                                                                                                  - Factors that influence serum potassium

                                                                                                  1 Surgical stress

                                                                                                  2 Injury

                                                                                                  3 Acidosis

                                                                                                  4 Tissue catabolism

                                                                                                  Hyperkalemia

                                                                                                  The normal range of serum potassium 35-5 meqL

                                                                                                  Etiology of Hyperkalemia

                                                                                                  Increased intake Potassium supplementation

                                                                                                  Blood transfusions

                                                                                                  Endogenous loaddestruction

                                                                                                  hemolysis rhabdomyolysis

                                                                                                  cruch injury gastrointestinal hemorrhage

                                                                                                  Increased release Acidosis

                                                                                                  Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                  Renal insufficiencyfailure

                                                                                                  Clinical manifestation of hyperkalemia

                                                                                                  System hyperkalemia

                                                                                                  Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                  Neuromuscular weakness paralysis respiratory failure

                                                                                                  Cardiovascular Arrhythmia arrest

                                                                                                  ECG changes Peaked T waves (early change)

                                                                                                  Flattened P wave

                                                                                                  Prolonged PR interval (first-degree block)

                                                                                                  Widened QRS complex

                                                                                                  Sine wave formation

                                                                                                  Ventricular fibrillation

                                                                                                  Treatment

                                                                                                  Treatment of symptomatic hyperkalemia

                                                                                                  Potassium removal Kayexalate

                                                                                                  Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                  Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                  Dialysis

                                                                                                  Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                  Bicarbonate 1 vial intravenous

                                                                                                  Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                  HypokalemiaEtiology

                                                                                                  inadequate intake

                                                                                                  Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                  total parenteral nutrition

                                                                                                  Excessive potassium excretion

                                                                                                  Hyperaldosteronism

                                                                                                  Medications

                                                                                                  Gastrointestinal losses

                                                                                                  Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                  Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                  nasogastric output)

                                                                                                  Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                  Potassium changes associated with alkalosis

                                                                                                  Potassium decrease by 03 meqL for every 01

                                                                                                  increase in PH above normal

                                                                                                  Magnesium Depletion

                                                                                                  (drug induced amphotericin amioglycosides cisplatin)

                                                                                                  Renal potassium wastage

                                                                                                  Hypokalemia

                                                                                                  Magnesium Depletion

                                                                                                  (drug induced amphotericin amioglycosides cisplatin)

                                                                                                  Renal potassium wastage

                                                                                                  Hypokalemia

                                                                                                  Clinical Manifestation of Abnormalities in potassium

                                                                                                  System hypokalemia

                                                                                                  Gastrointestinal Ileus constipation

                                                                                                  Neuromuscular Decreased reflexes fatigue weakness

                                                                                                  paralysis

                                                                                                  Cardiovascular Arrest

                                                                                                  ECG changes U-waves

                                                                                                  T-wave flattening

                                                                                                  ST-segment changes

                                                                                                  Arrhythmias

                                                                                                  Treatment

                                                                                                  Potassium

                                                                                                  Serum potassium level lt40 mEqL

                                                                                                  Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                  times 1 doses

                                                                                                  Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                  Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                  Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                  asymptomatic replace as per above protocol

                                                                                                  Electrolyte Replacement Therapy Protocol

                                                                                                  bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                  bull IV repletion for severe and symptomatic hypokalemia

                                                                                                  Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                  ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                  عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                  صاف 2 عضالت انقباض

                                                                                                  هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                  انعقاد 4

                                                                                                  یونیزه Calt45 meql هيپوكلسمي

                                                                                                  عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                  ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                  میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                  ( شود می پیوند شده

                                                                                                  هیپوکلسمی عالئم

                                                                                                  رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                  سایرعالئم

                                                                                                  قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                  درمان

                                                                                                  ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                  Cagt55meql هيپركلسمي

                                                                                                  هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                  عالئم

                                                                                                  bullGI

                                                                                                  bullCardiovascular bullRenal (polyuria)

                                                                                                  bullCNS

                                                                                                  قلبی عالئم

                                                                                                  bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                  QRS شدن )Q-Tوكوتاه

                                                                                                  درمان

                                                                                                  ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                  الزیکس2

                                                                                                  تونین 3 کلسی

                                                                                                  کورتون4

                                                                                                  دیالیز5

                                                                                                  Magnesium Abnormalities

                                                                                                  Normal dietary intake 20meq (240mg)

                                                                                                  Excretion in both the feces and urine

                                                                                                  Normal serum level 19-25 mgdL

                                                                                                  منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                  تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                  bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                  Hypermagnesemia

                                                                                                  Etiology

                                                                                                  1 Impaired renal function

                                                                                                  2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                  Clinical manifestation hypermanesemia

                                                                                                  System hypermanesemia

                                                                                                  Gastrointestinal Nauseavomiting

                                                                                                  Neuromuscular weakness lethargy Decreased

                                                                                                  reflexes

                                                                                                  Cardiovascular Hypotension arrest

                                                                                                  ECG changes Increased PR interval

                                                                                                  Widened QRS complex

                                                                                                  Elevated T waves

                                                                                                  Treatment

                                                                                                  1 Withhold exogenous sources of magnesium

                                                                                                  2 Correct volume deficit

                                                                                                  3 Correct acidosis if present

                                                                                                  4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                  5 Dialysis (if elevated levels or symptoms persist)

                                                                                                  عالئم

                                                                                                  bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                  meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                  meqL

                                                                                                  Hypomagnesemia

                                                                                                  Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                  homeostasis

                                                                                                  Etiology

                                                                                                  1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                  inadequate supplementation of magnesium)

                                                                                                  2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                  3 GI losses (diarrhea)

                                                                                                  4 Malabsorption

                                                                                                  5 Acute pancreatitis

                                                                                                  6 Diabetic ketoacidosis

                                                                                                  7 Primary aldosteronism

                                                                                                  Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                  1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                  2 Delirium and seizures in severe deficiency

                                                                                                  3 ECG changes Prolonged QT and PR interval

                                                                                                  ST-segment depression

                                                                                                  Flattening or inversion of P waves

                                                                                                  Torsades de pointes

                                                                                                  Arrhythmia

                                                                                                  Treatment

                                                                                                  1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                  2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                  Message for Today

                                                                                                  ICF

                                                                                                  Interstitial

                                                                                                  Pla

                                                                                                  sma

                                                                                                  5 Dex

                                                                                                  bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                  • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                  • Slide 2
                                                                                                  • Slide 3
                                                                                                  • Slide 4
                                                                                                  • Total Body Water
                                                                                                  • Body Fluid Compartments
                                                                                                  • Total body water (TBW)
                                                                                                  • Body compartment fluid
                                                                                                  • Example men with 70kg
                                                                                                  • Fluid compartments
                                                                                                  • Slide 11
                                                                                                  • Slide 12
                                                                                                  • Slide 13
                                                                                                  • Slide 14
                                                                                                  • Slide 15
                                                                                                  • Colloid osmotic pressure
                                                                                                  • Slide 17
                                                                                                  • Slide 18
                                                                                                  • Slide 19
                                                                                                  • Cell Membrane
                                                                                                  • Slide 21
                                                                                                  • Slide 22
                                                                                                  • Slide 23
                                                                                                  • Slide 24
                                                                                                  • Slide 25
                                                                                                  • Composition of Fluid Compartments
                                                                                                  • Composition of Body Fluids
                                                                                                  • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                  • Reasons for fluid therapy
                                                                                                  • ارزیابی حجم مایع داخل عروقی
                                                                                                  • محلولهای وریدی
                                                                                                  • Fluids
                                                                                                  • Slide 33
                                                                                                  • Slide 34
                                                                                                  • Slide 35
                                                                                                  • Crystalloids
                                                                                                  • Colloid Solutions
                                                                                                  • رینگر لاکتات
                                                                                                  • 09Nacl
                                                                                                  • Postoperative (maintenance)
                                                                                                  • Slide 41
                                                                                                  • Preexisting fluid deficits
                                                                                                  • Maintenance requirements
                                                                                                  • Surgical fluid losses
                                                                                                  • Third space loss
                                                                                                  • Crystalloid solution
                                                                                                  • Colloids
                                                                                                  • Complications
                                                                                                  • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                  • Colloid versus crystalloid solutions
                                                                                                  • Transfusion consideration
                                                                                                  • اختلال در حجم مایعات بدن
                                                                                                  • Fluid volume deficit (FVD)
                                                                                                  • DEHYDRATION
                                                                                                  • علل کاهش حجم خارج سلولی
                                                                                                  • Signs of Hypovolemia
                                                                                                  • Clinical Diagnosis of Hypovolemia
                                                                                                  • Signs of Hypervolemia
                                                                                                  • Management of Hypervolemia
                                                                                                  • Fluid Management
                                                                                                  • Electrolyte physiology
                                                                                                  • Sodium physiology
                                                                                                  • Osmotic Pressure
                                                                                                  • Concentration
                                                                                                  • Hypernatremia
                                                                                                  • - Hypernatremia
                                                                                                  • Slide 67
                                                                                                  • Slide 68
                                                                                                  • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                  • Treatment
                                                                                                  • Water deficit (L)= times TBW
                                                                                                  • The rate of fluid administration
                                                                                                  • Hyponatremia Nalt135mEqL
                                                                                                  • Slide 74
                                                                                                  • Sodium depletion
                                                                                                  • Sodium dilution
                                                                                                  • Sign and symptoms
                                                                                                  • Slide 78
                                                                                                  • Treatment
                                                                                                  • Slide 80
                                                                                                  • Slide 81
                                                                                                  • Dose
                                                                                                  • Potassium abnormalities
                                                                                                  • Hyperkalemia
                                                                                                  • Clinical manifestation of hyperkalemia
                                                                                                  • Slide 86
                                                                                                  • Slide 87
                                                                                                  • Hypokalemia
                                                                                                  • Potassium changes associated with alkalosis
                                                                                                  • Slide 90
                                                                                                  • Clinical Manifestation of Abnormalities in potassium
                                                                                                  • Slide 92
                                                                                                  • Calcium
                                                                                                  • هيپوكلسمي یونیزه Calt45 meql
                                                                                                  • علائم هیپوکلسمی
                                                                                                  • Slide 96
                                                                                                  • Slide 97
                                                                                                  • Slide 98
                                                                                                  • Slide 99
                                                                                                  • سایرعلائم
                                                                                                  • درمان
                                                                                                  • هيپركلسمي Cagt55meql
                                                                                                  • علائم
                                                                                                  • علائم قلبی
                                                                                                  • Slide 105
                                                                                                  • Magnesium Abnormalities
                                                                                                  • منیزیوم
                                                                                                  • Hypermagnesemia
                                                                                                  • Clinical manifestation hypermanesemia
                                                                                                  • Slide 110
                                                                                                  • Slide 111
                                                                                                  • Hypomagnesemia
                                                                                                  • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                  • Slide 114
                                                                                                  • Message for Today
                                                                                                  • Slide 116

                                                                                                    Transfusion consideration

                                                                                                    bull HB lt7 mg dl increase CO

                                                                                                    bull Ideal Hb is 7-8 mgdl

                                                                                                    bull In IHD patients or pulmonary disease gt 10 mgdl

                                                                                                    بدن مایعات حجم در اختالل

                                                                                                    1 Fluid volume deficit

                                                                                                    2 Fluid volume excess

                                                                                                    Fluid volume deficit(FVD)

                                                                                                    ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                                                    کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                                                    ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                                                    باشد آن با همراه دیگری اختالل مگر

                                                                                                    DEHYDRATION

                                                                                                    سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                                                    سلولی خارج حجم کاهش علل

                                                                                                    1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                                                    2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                                                    کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                                                    Signs of HypovolemiaSigns of Hypovolemia

                                                                                                    bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                                                    Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                                                    bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                                                    Signs of HypervolemiaSigns of Hypervolemia

                                                                                                    bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                                                    Especially when hypo-albuminemia

                                                                                                    Management of Management of HypervolemiaHypervolemia

                                                                                                    bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                                                    Fluid ManagementFluid Management

                                                                                                    bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                                    Electrolyte physiology

                                                                                                    Sodium physiology

                                                                                                    Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                                    Normal amount 135-145 meql

                                                                                                    Osmotic Pressure

                                                                                                    Calculated serum osmolality =

                                                                                                    2 sodium+ glucose18 + BUN 28

                                                                                                    Osmolality = 290 mosm

                                                                                                    Concentration

                                                                                                    1Serum sodium concentration2Serum osmolarity

                                                                                                    bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                                    drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                                    DW5)

                                                                                                    Hypernatremia

                                                                                                    Serum Nagt145mEqL

                                                                                                    - Hypernatremia

                                                                                                    Loss of Free Water

                                                                                                    Gain of sodium in excess of water

                                                                                                    Hypernatremia

                                                                                                    -Hypernatremia Hypo volemic

                                                                                                    Hyper volemic

                                                                                                    Normo volemic

                                                                                                    Hypernatremia

                                                                                                    Volume Status

                                                                                                    Normal

                                                                                                    Nonrenal water loss

                                                                                                    Skin

                                                                                                    Gastrointestinal

                                                                                                    Renal water loss

                                                                                                    Renal disease

                                                                                                    Diuretics

                                                                                                    Diabetes insipidus

                                                                                                    High

                                                                                                    Iatrogenic sodium administration

                                                                                                    Mineralocorticoid excess

                                                                                                    Aldosteronism

                                                                                                    Cushingrsquos disease

                                                                                                    Congenital adrenal

                                                                                                    hyperplasia

                                                                                                    Low

                                                                                                    Nonrenal water loss

                                                                                                    Skin

                                                                                                    Gastrointestinal losses

                                                                                                    Renal water losses

                                                                                                    Renal (tubular) Diuretics

                                                                                                    Osmotic diuretics

                                                                                                    Diabetes insipidus

                                                                                                    Adrenal failure

                                                                                                    Asymptomatic

                                                                                                    Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                    Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                    Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                    Body system hypernatremia

                                                                                                    Treatment

                                                                                                    Normal saline in hypovolemic patients

                                                                                                    Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                    saline or entral water)

                                                                                                    Water deficit (L)= times TBW

                                                                                                    The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                    Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                    Serum sodium-140

                                                                                                    140

                                                                                                    The rate of fluid administration

                                                                                                    1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                    2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                    Hyponatremia Nalt135mEqL

                                                                                                    Causes

                                                                                                    1 Sodium depletion

                                                                                                    2 Sodium dilution

                                                                                                    bull Incidence = 45

                                                                                                    bull After surgery=1

                                                                                                    bull Mortality = 2 times normal

                                                                                                    Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                    volume deficit

                                                                                                    Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                    Sign and symptoms

                                                                                                    bull CNS symptom when Nalt123 meql

                                                                                                    bull Cardiac symptom when Nalt100 meql

                                                                                                    For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                    Body System Hyponatremia

                                                                                                    central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                    reflexes seizures coma increased intracranial pressure

                                                                                                    Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                    Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                    Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                    intracranial pressure

                                                                                                    Tissue Lacrimation salivation

                                                                                                    Renal Oliguria

                                                                                                    Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                    Treatment

                                                                                                    1=Depend on ECF

                                                                                                    2=CNS sign

                                                                                                    Treatment

                                                                                                    1 Asymptomatic increase the sodium level by no more than

                                                                                                    05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                    2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                    more than 1meqL per hour until the serum Na level reaches 130

                                                                                                    meqL or neurologic symptoms are improved

                                                                                                    Rapid correction of hyponatremia

                                                                                                    Pontine myelinolysis

                                                                                                    Seizures weaknessparesis akinetic

                                                                                                    movements unresponsiveness

                                                                                                    Permanent brain damage

                                                                                                    Death

                                                                                                    Dose

                                                                                                    Na deficit meq =(140- Na meql) TBW

                                                                                                    باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                    شود اصالح آهسته سپس

                                                                                                    Potassium abnormalities

                                                                                                    bull The average dietary intake of potassium 50-100meqd

                                                                                                    bull The average renal excretion of potassium 10-700 meqd

                                                                                                    - 2 of the total body potassium in ECF (45meqL)

                                                                                                    - Factors that influence serum potassium

                                                                                                    1 Surgical stress

                                                                                                    2 Injury

                                                                                                    3 Acidosis

                                                                                                    4 Tissue catabolism

                                                                                                    Hyperkalemia

                                                                                                    The normal range of serum potassium 35-5 meqL

                                                                                                    Etiology of Hyperkalemia

                                                                                                    Increased intake Potassium supplementation

                                                                                                    Blood transfusions

                                                                                                    Endogenous loaddestruction

                                                                                                    hemolysis rhabdomyolysis

                                                                                                    cruch injury gastrointestinal hemorrhage

                                                                                                    Increased release Acidosis

                                                                                                    Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                    Renal insufficiencyfailure

                                                                                                    Clinical manifestation of hyperkalemia

                                                                                                    System hyperkalemia

                                                                                                    Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                    Neuromuscular weakness paralysis respiratory failure

                                                                                                    Cardiovascular Arrhythmia arrest

                                                                                                    ECG changes Peaked T waves (early change)

                                                                                                    Flattened P wave

                                                                                                    Prolonged PR interval (first-degree block)

                                                                                                    Widened QRS complex

                                                                                                    Sine wave formation

                                                                                                    Ventricular fibrillation

                                                                                                    Treatment

                                                                                                    Treatment of symptomatic hyperkalemia

                                                                                                    Potassium removal Kayexalate

                                                                                                    Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                    Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                    Dialysis

                                                                                                    Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                    Bicarbonate 1 vial intravenous

                                                                                                    Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                    HypokalemiaEtiology

                                                                                                    inadequate intake

                                                                                                    Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                    total parenteral nutrition

                                                                                                    Excessive potassium excretion

                                                                                                    Hyperaldosteronism

                                                                                                    Medications

                                                                                                    Gastrointestinal losses

                                                                                                    Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                    Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                    nasogastric output)

                                                                                                    Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                    Potassium changes associated with alkalosis

                                                                                                    Potassium decrease by 03 meqL for every 01

                                                                                                    increase in PH above normal

                                                                                                    Magnesium Depletion

                                                                                                    (drug induced amphotericin amioglycosides cisplatin)

                                                                                                    Renal potassium wastage

                                                                                                    Hypokalemia

                                                                                                    Magnesium Depletion

                                                                                                    (drug induced amphotericin amioglycosides cisplatin)

                                                                                                    Renal potassium wastage

                                                                                                    Hypokalemia

                                                                                                    Clinical Manifestation of Abnormalities in potassium

                                                                                                    System hypokalemia

                                                                                                    Gastrointestinal Ileus constipation

                                                                                                    Neuromuscular Decreased reflexes fatigue weakness

                                                                                                    paralysis

                                                                                                    Cardiovascular Arrest

                                                                                                    ECG changes U-waves

                                                                                                    T-wave flattening

                                                                                                    ST-segment changes

                                                                                                    Arrhythmias

                                                                                                    Treatment

                                                                                                    Potassium

                                                                                                    Serum potassium level lt40 mEqL

                                                                                                    Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                    times 1 doses

                                                                                                    Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                    Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                    Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                    asymptomatic replace as per above protocol

                                                                                                    Electrolyte Replacement Therapy Protocol

                                                                                                    bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                    bull IV repletion for severe and symptomatic hypokalemia

                                                                                                    Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                    ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                    عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                    صاف 2 عضالت انقباض

                                                                                                    هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                    انعقاد 4

                                                                                                    یونیزه Calt45 meql هيپوكلسمي

                                                                                                    عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                    ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                    میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                    ( شود می پیوند شده

                                                                                                    هیپوکلسمی عالئم

                                                                                                    رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                    سایرعالئم

                                                                                                    قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                    درمان

                                                                                                    ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                    Cagt55meql هيپركلسمي

                                                                                                    هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                    عالئم

                                                                                                    bullGI

                                                                                                    bullCardiovascular bullRenal (polyuria)

                                                                                                    bullCNS

                                                                                                    قلبی عالئم

                                                                                                    bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                    QRS شدن )Q-Tوكوتاه

                                                                                                    درمان

                                                                                                    ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                    الزیکس2

                                                                                                    تونین 3 کلسی

                                                                                                    کورتون4

                                                                                                    دیالیز5

                                                                                                    Magnesium Abnormalities

                                                                                                    Normal dietary intake 20meq (240mg)

                                                                                                    Excretion in both the feces and urine

                                                                                                    Normal serum level 19-25 mgdL

                                                                                                    منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                    تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                    bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                    Hypermagnesemia

                                                                                                    Etiology

                                                                                                    1 Impaired renal function

                                                                                                    2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                    Clinical manifestation hypermanesemia

                                                                                                    System hypermanesemia

                                                                                                    Gastrointestinal Nauseavomiting

                                                                                                    Neuromuscular weakness lethargy Decreased

                                                                                                    reflexes

                                                                                                    Cardiovascular Hypotension arrest

                                                                                                    ECG changes Increased PR interval

                                                                                                    Widened QRS complex

                                                                                                    Elevated T waves

                                                                                                    Treatment

                                                                                                    1 Withhold exogenous sources of magnesium

                                                                                                    2 Correct volume deficit

                                                                                                    3 Correct acidosis if present

                                                                                                    4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                    5 Dialysis (if elevated levels or symptoms persist)

                                                                                                    عالئم

                                                                                                    bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                    meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                    meqL

                                                                                                    Hypomagnesemia

                                                                                                    Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                    homeostasis

                                                                                                    Etiology

                                                                                                    1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                    inadequate supplementation of magnesium)

                                                                                                    2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                    3 GI losses (diarrhea)

                                                                                                    4 Malabsorption

                                                                                                    5 Acute pancreatitis

                                                                                                    6 Diabetic ketoacidosis

                                                                                                    7 Primary aldosteronism

                                                                                                    Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                    1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                    2 Delirium and seizures in severe deficiency

                                                                                                    3 ECG changes Prolonged QT and PR interval

                                                                                                    ST-segment depression

                                                                                                    Flattening or inversion of P waves

                                                                                                    Torsades de pointes

                                                                                                    Arrhythmia

                                                                                                    Treatment

                                                                                                    1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                    2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                    Message for Today

                                                                                                    ICF

                                                                                                    Interstitial

                                                                                                    Pla

                                                                                                    sma

                                                                                                    5 Dex

                                                                                                    bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                    • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                    • Slide 2
                                                                                                    • Slide 3
                                                                                                    • Slide 4
                                                                                                    • Total Body Water
                                                                                                    • Body Fluid Compartments
                                                                                                    • Total body water (TBW)
                                                                                                    • Body compartment fluid
                                                                                                    • Example men with 70kg
                                                                                                    • Fluid compartments
                                                                                                    • Slide 11
                                                                                                    • Slide 12
                                                                                                    • Slide 13
                                                                                                    • Slide 14
                                                                                                    • Slide 15
                                                                                                    • Colloid osmotic pressure
                                                                                                    • Slide 17
                                                                                                    • Slide 18
                                                                                                    • Slide 19
                                                                                                    • Cell Membrane
                                                                                                    • Slide 21
                                                                                                    • Slide 22
                                                                                                    • Slide 23
                                                                                                    • Slide 24
                                                                                                    • Slide 25
                                                                                                    • Composition of Fluid Compartments
                                                                                                    • Composition of Body Fluids
                                                                                                    • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                    • Reasons for fluid therapy
                                                                                                    • ارزیابی حجم مایع داخل عروقی
                                                                                                    • محلولهای وریدی
                                                                                                    • Fluids
                                                                                                    • Slide 33
                                                                                                    • Slide 34
                                                                                                    • Slide 35
                                                                                                    • Crystalloids
                                                                                                    • Colloid Solutions
                                                                                                    • رینگر لاکتات
                                                                                                    • 09Nacl
                                                                                                    • Postoperative (maintenance)
                                                                                                    • Slide 41
                                                                                                    • Preexisting fluid deficits
                                                                                                    • Maintenance requirements
                                                                                                    • Surgical fluid losses
                                                                                                    • Third space loss
                                                                                                    • Crystalloid solution
                                                                                                    • Colloids
                                                                                                    • Complications
                                                                                                    • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                    • Colloid versus crystalloid solutions
                                                                                                    • Transfusion consideration
                                                                                                    • اختلال در حجم مایعات بدن
                                                                                                    • Fluid volume deficit (FVD)
                                                                                                    • DEHYDRATION
                                                                                                    • علل کاهش حجم خارج سلولی
                                                                                                    • Signs of Hypovolemia
                                                                                                    • Clinical Diagnosis of Hypovolemia
                                                                                                    • Signs of Hypervolemia
                                                                                                    • Management of Hypervolemia
                                                                                                    • Fluid Management
                                                                                                    • Electrolyte physiology
                                                                                                    • Sodium physiology
                                                                                                    • Osmotic Pressure
                                                                                                    • Concentration
                                                                                                    • Hypernatremia
                                                                                                    • - Hypernatremia
                                                                                                    • Slide 67
                                                                                                    • Slide 68
                                                                                                    • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                    • Treatment
                                                                                                    • Water deficit (L)= times TBW
                                                                                                    • The rate of fluid administration
                                                                                                    • Hyponatremia Nalt135mEqL
                                                                                                    • Slide 74
                                                                                                    • Sodium depletion
                                                                                                    • Sodium dilution
                                                                                                    • Sign and symptoms
                                                                                                    • Slide 78
                                                                                                    • Treatment
                                                                                                    • Slide 80
                                                                                                    • Slide 81
                                                                                                    • Dose
                                                                                                    • Potassium abnormalities
                                                                                                    • Hyperkalemia
                                                                                                    • Clinical manifestation of hyperkalemia
                                                                                                    • Slide 86
                                                                                                    • Slide 87
                                                                                                    • Hypokalemia
                                                                                                    • Potassium changes associated with alkalosis
                                                                                                    • Slide 90
                                                                                                    • Clinical Manifestation of Abnormalities in potassium
                                                                                                    • Slide 92
                                                                                                    • Calcium
                                                                                                    • هيپوكلسمي یونیزه Calt45 meql
                                                                                                    • علائم هیپوکلسمی
                                                                                                    • Slide 96
                                                                                                    • Slide 97
                                                                                                    • Slide 98
                                                                                                    • Slide 99
                                                                                                    • سایرعلائم
                                                                                                    • درمان
                                                                                                    • هيپركلسمي Cagt55meql
                                                                                                    • علائم
                                                                                                    • علائم قلبی
                                                                                                    • Slide 105
                                                                                                    • Magnesium Abnormalities
                                                                                                    • منیزیوم
                                                                                                    • Hypermagnesemia
                                                                                                    • Clinical manifestation hypermanesemia
                                                                                                    • Slide 110
                                                                                                    • Slide 111
                                                                                                    • Hypomagnesemia
                                                                                                    • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                    • Slide 114
                                                                                                    • Message for Today
                                                                                                    • Slide 116

                                                                                                      بدن مایعات حجم در اختالل

                                                                                                      1 Fluid volume deficit

                                                                                                      2 Fluid volume excess

                                                                                                      Fluid volume deficit(FVD)

                                                                                                      ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                                                      کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                                                      ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                                                      باشد آن با همراه دیگری اختالل مگر

                                                                                                      DEHYDRATION

                                                                                                      سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                                                      سلولی خارج حجم کاهش علل

                                                                                                      1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                                                      2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                                                      کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                                                      Signs of HypovolemiaSigns of Hypovolemia

                                                                                                      bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                                                      Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                                                      bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                                                      Signs of HypervolemiaSigns of Hypervolemia

                                                                                                      bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                                                      Especially when hypo-albuminemia

                                                                                                      Management of Management of HypervolemiaHypervolemia

                                                                                                      bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                                                      Fluid ManagementFluid Management

                                                                                                      bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                                      Electrolyte physiology

                                                                                                      Sodium physiology

                                                                                                      Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                                      Normal amount 135-145 meql

                                                                                                      Osmotic Pressure

                                                                                                      Calculated serum osmolality =

                                                                                                      2 sodium+ glucose18 + BUN 28

                                                                                                      Osmolality = 290 mosm

                                                                                                      Concentration

                                                                                                      1Serum sodium concentration2Serum osmolarity

                                                                                                      bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                                      drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                                      DW5)

                                                                                                      Hypernatremia

                                                                                                      Serum Nagt145mEqL

                                                                                                      - Hypernatremia

                                                                                                      Loss of Free Water

                                                                                                      Gain of sodium in excess of water

                                                                                                      Hypernatremia

                                                                                                      -Hypernatremia Hypo volemic

                                                                                                      Hyper volemic

                                                                                                      Normo volemic

                                                                                                      Hypernatremia

                                                                                                      Volume Status

                                                                                                      Normal

                                                                                                      Nonrenal water loss

                                                                                                      Skin

                                                                                                      Gastrointestinal

                                                                                                      Renal water loss

                                                                                                      Renal disease

                                                                                                      Diuretics

                                                                                                      Diabetes insipidus

                                                                                                      High

                                                                                                      Iatrogenic sodium administration

                                                                                                      Mineralocorticoid excess

                                                                                                      Aldosteronism

                                                                                                      Cushingrsquos disease

                                                                                                      Congenital adrenal

                                                                                                      hyperplasia

                                                                                                      Low

                                                                                                      Nonrenal water loss

                                                                                                      Skin

                                                                                                      Gastrointestinal losses

                                                                                                      Renal water losses

                                                                                                      Renal (tubular) Diuretics

                                                                                                      Osmotic diuretics

                                                                                                      Diabetes insipidus

                                                                                                      Adrenal failure

                                                                                                      Asymptomatic

                                                                                                      Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                      Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                      Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                      Body system hypernatremia

                                                                                                      Treatment

                                                                                                      Normal saline in hypovolemic patients

                                                                                                      Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                      saline or entral water)

                                                                                                      Water deficit (L)= times TBW

                                                                                                      The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                      Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                      Serum sodium-140

                                                                                                      140

                                                                                                      The rate of fluid administration

                                                                                                      1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                      2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                      Hyponatremia Nalt135mEqL

                                                                                                      Causes

                                                                                                      1 Sodium depletion

                                                                                                      2 Sodium dilution

                                                                                                      bull Incidence = 45

                                                                                                      bull After surgery=1

                                                                                                      bull Mortality = 2 times normal

                                                                                                      Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                      volume deficit

                                                                                                      Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                      Sign and symptoms

                                                                                                      bull CNS symptom when Nalt123 meql

                                                                                                      bull Cardiac symptom when Nalt100 meql

                                                                                                      For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                      Body System Hyponatremia

                                                                                                      central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                      reflexes seizures coma increased intracranial pressure

                                                                                                      Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                      Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                      Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                      intracranial pressure

                                                                                                      Tissue Lacrimation salivation

                                                                                                      Renal Oliguria

                                                                                                      Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                      Treatment

                                                                                                      1=Depend on ECF

                                                                                                      2=CNS sign

                                                                                                      Treatment

                                                                                                      1 Asymptomatic increase the sodium level by no more than

                                                                                                      05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                      2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                      more than 1meqL per hour until the serum Na level reaches 130

                                                                                                      meqL or neurologic symptoms are improved

                                                                                                      Rapid correction of hyponatremia

                                                                                                      Pontine myelinolysis

                                                                                                      Seizures weaknessparesis akinetic

                                                                                                      movements unresponsiveness

                                                                                                      Permanent brain damage

                                                                                                      Death

                                                                                                      Dose

                                                                                                      Na deficit meq =(140- Na meql) TBW

                                                                                                      باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                      شود اصالح آهسته سپس

                                                                                                      Potassium abnormalities

                                                                                                      bull The average dietary intake of potassium 50-100meqd

                                                                                                      bull The average renal excretion of potassium 10-700 meqd

                                                                                                      - 2 of the total body potassium in ECF (45meqL)

                                                                                                      - Factors that influence serum potassium

                                                                                                      1 Surgical stress

                                                                                                      2 Injury

                                                                                                      3 Acidosis

                                                                                                      4 Tissue catabolism

                                                                                                      Hyperkalemia

                                                                                                      The normal range of serum potassium 35-5 meqL

                                                                                                      Etiology of Hyperkalemia

                                                                                                      Increased intake Potassium supplementation

                                                                                                      Blood transfusions

                                                                                                      Endogenous loaddestruction

                                                                                                      hemolysis rhabdomyolysis

                                                                                                      cruch injury gastrointestinal hemorrhage

                                                                                                      Increased release Acidosis

                                                                                                      Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                      Renal insufficiencyfailure

                                                                                                      Clinical manifestation of hyperkalemia

                                                                                                      System hyperkalemia

                                                                                                      Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                      Neuromuscular weakness paralysis respiratory failure

                                                                                                      Cardiovascular Arrhythmia arrest

                                                                                                      ECG changes Peaked T waves (early change)

                                                                                                      Flattened P wave

                                                                                                      Prolonged PR interval (first-degree block)

                                                                                                      Widened QRS complex

                                                                                                      Sine wave formation

                                                                                                      Ventricular fibrillation

                                                                                                      Treatment

                                                                                                      Treatment of symptomatic hyperkalemia

                                                                                                      Potassium removal Kayexalate

                                                                                                      Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                      Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                      Dialysis

                                                                                                      Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                      Bicarbonate 1 vial intravenous

                                                                                                      Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                      HypokalemiaEtiology

                                                                                                      inadequate intake

                                                                                                      Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                      total parenteral nutrition

                                                                                                      Excessive potassium excretion

                                                                                                      Hyperaldosteronism

                                                                                                      Medications

                                                                                                      Gastrointestinal losses

                                                                                                      Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                      Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                      nasogastric output)

                                                                                                      Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                      Potassium changes associated with alkalosis

                                                                                                      Potassium decrease by 03 meqL for every 01

                                                                                                      increase in PH above normal

                                                                                                      Magnesium Depletion

                                                                                                      (drug induced amphotericin amioglycosides cisplatin)

                                                                                                      Renal potassium wastage

                                                                                                      Hypokalemia

                                                                                                      Magnesium Depletion

                                                                                                      (drug induced amphotericin amioglycosides cisplatin)

                                                                                                      Renal potassium wastage

                                                                                                      Hypokalemia

                                                                                                      Clinical Manifestation of Abnormalities in potassium

                                                                                                      System hypokalemia

                                                                                                      Gastrointestinal Ileus constipation

                                                                                                      Neuromuscular Decreased reflexes fatigue weakness

                                                                                                      paralysis

                                                                                                      Cardiovascular Arrest

                                                                                                      ECG changes U-waves

                                                                                                      T-wave flattening

                                                                                                      ST-segment changes

                                                                                                      Arrhythmias

                                                                                                      Treatment

                                                                                                      Potassium

                                                                                                      Serum potassium level lt40 mEqL

                                                                                                      Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                      times 1 doses

                                                                                                      Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                      Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                      Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                      asymptomatic replace as per above protocol

                                                                                                      Electrolyte Replacement Therapy Protocol

                                                                                                      bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                      bull IV repletion for severe and symptomatic hypokalemia

                                                                                                      Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                      ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                      عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                      صاف 2 عضالت انقباض

                                                                                                      هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                      انعقاد 4

                                                                                                      یونیزه Calt45 meql هيپوكلسمي

                                                                                                      عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                      ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                      میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                      ( شود می پیوند شده

                                                                                                      هیپوکلسمی عالئم

                                                                                                      رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                      سایرعالئم

                                                                                                      قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                      درمان

                                                                                                      ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                      Cagt55meql هيپركلسمي

                                                                                                      هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                      عالئم

                                                                                                      bullGI

                                                                                                      bullCardiovascular bullRenal (polyuria)

                                                                                                      bullCNS

                                                                                                      قلبی عالئم

                                                                                                      bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                      QRS شدن )Q-Tوكوتاه

                                                                                                      درمان

                                                                                                      ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                      الزیکس2

                                                                                                      تونین 3 کلسی

                                                                                                      کورتون4

                                                                                                      دیالیز5

                                                                                                      Magnesium Abnormalities

                                                                                                      Normal dietary intake 20meq (240mg)

                                                                                                      Excretion in both the feces and urine

                                                                                                      Normal serum level 19-25 mgdL

                                                                                                      منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                      تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                      bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                      Hypermagnesemia

                                                                                                      Etiology

                                                                                                      1 Impaired renal function

                                                                                                      2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                      Clinical manifestation hypermanesemia

                                                                                                      System hypermanesemia

                                                                                                      Gastrointestinal Nauseavomiting

                                                                                                      Neuromuscular weakness lethargy Decreased

                                                                                                      reflexes

                                                                                                      Cardiovascular Hypotension arrest

                                                                                                      ECG changes Increased PR interval

                                                                                                      Widened QRS complex

                                                                                                      Elevated T waves

                                                                                                      Treatment

                                                                                                      1 Withhold exogenous sources of magnesium

                                                                                                      2 Correct volume deficit

                                                                                                      3 Correct acidosis if present

                                                                                                      4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                      5 Dialysis (if elevated levels or symptoms persist)

                                                                                                      عالئم

                                                                                                      bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                      meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                      meqL

                                                                                                      Hypomagnesemia

                                                                                                      Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                      homeostasis

                                                                                                      Etiology

                                                                                                      1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                      inadequate supplementation of magnesium)

                                                                                                      2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                      3 GI losses (diarrhea)

                                                                                                      4 Malabsorption

                                                                                                      5 Acute pancreatitis

                                                                                                      6 Diabetic ketoacidosis

                                                                                                      7 Primary aldosteronism

                                                                                                      Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                      1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                      2 Delirium and seizures in severe deficiency

                                                                                                      3 ECG changes Prolonged QT and PR interval

                                                                                                      ST-segment depression

                                                                                                      Flattening or inversion of P waves

                                                                                                      Torsades de pointes

                                                                                                      Arrhythmia

                                                                                                      Treatment

                                                                                                      1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                      2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                      Message for Today

                                                                                                      ICF

                                                                                                      Interstitial

                                                                                                      Pla

                                                                                                      sma

                                                                                                      5 Dex

                                                                                                      bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                      • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                      • Slide 2
                                                                                                      • Slide 3
                                                                                                      • Slide 4
                                                                                                      • Total Body Water
                                                                                                      • Body Fluid Compartments
                                                                                                      • Total body water (TBW)
                                                                                                      • Body compartment fluid
                                                                                                      • Example men with 70kg
                                                                                                      • Fluid compartments
                                                                                                      • Slide 11
                                                                                                      • Slide 12
                                                                                                      • Slide 13
                                                                                                      • Slide 14
                                                                                                      • Slide 15
                                                                                                      • Colloid osmotic pressure
                                                                                                      • Slide 17
                                                                                                      • Slide 18
                                                                                                      • Slide 19
                                                                                                      • Cell Membrane
                                                                                                      • Slide 21
                                                                                                      • Slide 22
                                                                                                      • Slide 23
                                                                                                      • Slide 24
                                                                                                      • Slide 25
                                                                                                      • Composition of Fluid Compartments
                                                                                                      • Composition of Body Fluids
                                                                                                      • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                      • Reasons for fluid therapy
                                                                                                      • ارزیابی حجم مایع داخل عروقی
                                                                                                      • محلولهای وریدی
                                                                                                      • Fluids
                                                                                                      • Slide 33
                                                                                                      • Slide 34
                                                                                                      • Slide 35
                                                                                                      • Crystalloids
                                                                                                      • Colloid Solutions
                                                                                                      • رینگر لاکتات
                                                                                                      • 09Nacl
                                                                                                      • Postoperative (maintenance)
                                                                                                      • Slide 41
                                                                                                      • Preexisting fluid deficits
                                                                                                      • Maintenance requirements
                                                                                                      • Surgical fluid losses
                                                                                                      • Third space loss
                                                                                                      • Crystalloid solution
                                                                                                      • Colloids
                                                                                                      • Complications
                                                                                                      • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                      • Colloid versus crystalloid solutions
                                                                                                      • Transfusion consideration
                                                                                                      • اختلال در حجم مایعات بدن
                                                                                                      • Fluid volume deficit (FVD)
                                                                                                      • DEHYDRATION
                                                                                                      • علل کاهش حجم خارج سلولی
                                                                                                      • Signs of Hypovolemia
                                                                                                      • Clinical Diagnosis of Hypovolemia
                                                                                                      • Signs of Hypervolemia
                                                                                                      • Management of Hypervolemia
                                                                                                      • Fluid Management
                                                                                                      • Electrolyte physiology
                                                                                                      • Sodium physiology
                                                                                                      • Osmotic Pressure
                                                                                                      • Concentration
                                                                                                      • Hypernatremia
                                                                                                      • - Hypernatremia
                                                                                                      • Slide 67
                                                                                                      • Slide 68
                                                                                                      • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                      • Treatment
                                                                                                      • Water deficit (L)= times TBW
                                                                                                      • The rate of fluid administration
                                                                                                      • Hyponatremia Nalt135mEqL
                                                                                                      • Slide 74
                                                                                                      • Sodium depletion
                                                                                                      • Sodium dilution
                                                                                                      • Sign and symptoms
                                                                                                      • Slide 78
                                                                                                      • Treatment
                                                                                                      • Slide 80
                                                                                                      • Slide 81
                                                                                                      • Dose
                                                                                                      • Potassium abnormalities
                                                                                                      • Hyperkalemia
                                                                                                      • Clinical manifestation of hyperkalemia
                                                                                                      • Slide 86
                                                                                                      • Slide 87
                                                                                                      • Hypokalemia
                                                                                                      • Potassium changes associated with alkalosis
                                                                                                      • Slide 90
                                                                                                      • Clinical Manifestation of Abnormalities in potassium
                                                                                                      • Slide 92
                                                                                                      • Calcium
                                                                                                      • هيپوكلسمي یونیزه Calt45 meql
                                                                                                      • علائم هیپوکلسمی
                                                                                                      • Slide 96
                                                                                                      • Slide 97
                                                                                                      • Slide 98
                                                                                                      • Slide 99
                                                                                                      • سایرعلائم
                                                                                                      • درمان
                                                                                                      • هيپركلسمي Cagt55meql
                                                                                                      • علائم
                                                                                                      • علائم قلبی
                                                                                                      • Slide 105
                                                                                                      • Magnesium Abnormalities
                                                                                                      • منیزیوم
                                                                                                      • Hypermagnesemia
                                                                                                      • Clinical manifestation hypermanesemia
                                                                                                      • Slide 110
                                                                                                      • Slide 111
                                                                                                      • Hypomagnesemia
                                                                                                      • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                      • Slide 114
                                                                                                      • Message for Today
                                                                                                      • Slide 116

                                                                                                        Fluid volume deficit(FVD)

                                                                                                        ) مایعات در که نسبتی به بدن والکترولیتهای آب کاهشنسبت ) که صورتی به دارد وجود بدن طبیعی

                                                                                                        کاهش بماند باقی یکنواخت آب به بدن الکترولیتهایمایع آمد FVDحجم خواهد وجود کاهش( به

                                                                                                        ایزوتونیک)در سرم الکترولیتهای میماند FVDمیزان باقی نرمال

                                                                                                        باشد آن با همراه دیگری اختالل مگر

                                                                                                        DEHYDRATION

                                                                                                        سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                                                        سلولی خارج حجم کاهش علل

                                                                                                        1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                                                        2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                                                        کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                                                        Signs of HypovolemiaSigns of Hypovolemia

                                                                                                        bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                                                        Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                                                        bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                                                        Signs of HypervolemiaSigns of Hypervolemia

                                                                                                        bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                                                        Especially when hypo-albuminemia

                                                                                                        Management of Management of HypervolemiaHypervolemia

                                                                                                        bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                                                        Fluid ManagementFluid Management

                                                                                                        bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                                        Electrolyte physiology

                                                                                                        Sodium physiology

                                                                                                        Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                                        Normal amount 135-145 meql

                                                                                                        Osmotic Pressure

                                                                                                        Calculated serum osmolality =

                                                                                                        2 sodium+ glucose18 + BUN 28

                                                                                                        Osmolality = 290 mosm

                                                                                                        Concentration

                                                                                                        1Serum sodium concentration2Serum osmolarity

                                                                                                        bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                                        drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                                        DW5)

                                                                                                        Hypernatremia

                                                                                                        Serum Nagt145mEqL

                                                                                                        - Hypernatremia

                                                                                                        Loss of Free Water

                                                                                                        Gain of sodium in excess of water

                                                                                                        Hypernatremia

                                                                                                        -Hypernatremia Hypo volemic

                                                                                                        Hyper volemic

                                                                                                        Normo volemic

                                                                                                        Hypernatremia

                                                                                                        Volume Status

                                                                                                        Normal

                                                                                                        Nonrenal water loss

                                                                                                        Skin

                                                                                                        Gastrointestinal

                                                                                                        Renal water loss

                                                                                                        Renal disease

                                                                                                        Diuretics

                                                                                                        Diabetes insipidus

                                                                                                        High

                                                                                                        Iatrogenic sodium administration

                                                                                                        Mineralocorticoid excess

                                                                                                        Aldosteronism

                                                                                                        Cushingrsquos disease

                                                                                                        Congenital adrenal

                                                                                                        hyperplasia

                                                                                                        Low

                                                                                                        Nonrenal water loss

                                                                                                        Skin

                                                                                                        Gastrointestinal losses

                                                                                                        Renal water losses

                                                                                                        Renal (tubular) Diuretics

                                                                                                        Osmotic diuretics

                                                                                                        Diabetes insipidus

                                                                                                        Adrenal failure

                                                                                                        Asymptomatic

                                                                                                        Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                        Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                        Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                        Body system hypernatremia

                                                                                                        Treatment

                                                                                                        Normal saline in hypovolemic patients

                                                                                                        Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                        saline or entral water)

                                                                                                        Water deficit (L)= times TBW

                                                                                                        The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                        Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                        Serum sodium-140

                                                                                                        140

                                                                                                        The rate of fluid administration

                                                                                                        1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                        2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                        Hyponatremia Nalt135mEqL

                                                                                                        Causes

                                                                                                        1 Sodium depletion

                                                                                                        2 Sodium dilution

                                                                                                        bull Incidence = 45

                                                                                                        bull After surgery=1

                                                                                                        bull Mortality = 2 times normal

                                                                                                        Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                        volume deficit

                                                                                                        Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                        Sign and symptoms

                                                                                                        bull CNS symptom when Nalt123 meql

                                                                                                        bull Cardiac symptom when Nalt100 meql

                                                                                                        For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                        Body System Hyponatremia

                                                                                                        central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                        reflexes seizures coma increased intracranial pressure

                                                                                                        Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                        Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                        Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                        intracranial pressure

                                                                                                        Tissue Lacrimation salivation

                                                                                                        Renal Oliguria

                                                                                                        Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                        Treatment

                                                                                                        1=Depend on ECF

                                                                                                        2=CNS sign

                                                                                                        Treatment

                                                                                                        1 Asymptomatic increase the sodium level by no more than

                                                                                                        05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                        2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                        more than 1meqL per hour until the serum Na level reaches 130

                                                                                                        meqL or neurologic symptoms are improved

                                                                                                        Rapid correction of hyponatremia

                                                                                                        Pontine myelinolysis

                                                                                                        Seizures weaknessparesis akinetic

                                                                                                        movements unresponsiveness

                                                                                                        Permanent brain damage

                                                                                                        Death

                                                                                                        Dose

                                                                                                        Na deficit meq =(140- Na meql) TBW

                                                                                                        باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                        شود اصالح آهسته سپس

                                                                                                        Potassium abnormalities

                                                                                                        bull The average dietary intake of potassium 50-100meqd

                                                                                                        bull The average renal excretion of potassium 10-700 meqd

                                                                                                        - 2 of the total body potassium in ECF (45meqL)

                                                                                                        - Factors that influence serum potassium

                                                                                                        1 Surgical stress

                                                                                                        2 Injury

                                                                                                        3 Acidosis

                                                                                                        4 Tissue catabolism

                                                                                                        Hyperkalemia

                                                                                                        The normal range of serum potassium 35-5 meqL

                                                                                                        Etiology of Hyperkalemia

                                                                                                        Increased intake Potassium supplementation

                                                                                                        Blood transfusions

                                                                                                        Endogenous loaddestruction

                                                                                                        hemolysis rhabdomyolysis

                                                                                                        cruch injury gastrointestinal hemorrhage

                                                                                                        Increased release Acidosis

                                                                                                        Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                        Renal insufficiencyfailure

                                                                                                        Clinical manifestation of hyperkalemia

                                                                                                        System hyperkalemia

                                                                                                        Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                        Neuromuscular weakness paralysis respiratory failure

                                                                                                        Cardiovascular Arrhythmia arrest

                                                                                                        ECG changes Peaked T waves (early change)

                                                                                                        Flattened P wave

                                                                                                        Prolonged PR interval (first-degree block)

                                                                                                        Widened QRS complex

                                                                                                        Sine wave formation

                                                                                                        Ventricular fibrillation

                                                                                                        Treatment

                                                                                                        Treatment of symptomatic hyperkalemia

                                                                                                        Potassium removal Kayexalate

                                                                                                        Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                        Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                        Dialysis

                                                                                                        Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                        Bicarbonate 1 vial intravenous

                                                                                                        Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                        HypokalemiaEtiology

                                                                                                        inadequate intake

                                                                                                        Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                        total parenteral nutrition

                                                                                                        Excessive potassium excretion

                                                                                                        Hyperaldosteronism

                                                                                                        Medications

                                                                                                        Gastrointestinal losses

                                                                                                        Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                        Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                        nasogastric output)

                                                                                                        Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                        Potassium changes associated with alkalosis

                                                                                                        Potassium decrease by 03 meqL for every 01

                                                                                                        increase in PH above normal

                                                                                                        Magnesium Depletion

                                                                                                        (drug induced amphotericin amioglycosides cisplatin)

                                                                                                        Renal potassium wastage

                                                                                                        Hypokalemia

                                                                                                        Magnesium Depletion

                                                                                                        (drug induced amphotericin amioglycosides cisplatin)

                                                                                                        Renal potassium wastage

                                                                                                        Hypokalemia

                                                                                                        Clinical Manifestation of Abnormalities in potassium

                                                                                                        System hypokalemia

                                                                                                        Gastrointestinal Ileus constipation

                                                                                                        Neuromuscular Decreased reflexes fatigue weakness

                                                                                                        paralysis

                                                                                                        Cardiovascular Arrest

                                                                                                        ECG changes U-waves

                                                                                                        T-wave flattening

                                                                                                        ST-segment changes

                                                                                                        Arrhythmias

                                                                                                        Treatment

                                                                                                        Potassium

                                                                                                        Serum potassium level lt40 mEqL

                                                                                                        Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                        times 1 doses

                                                                                                        Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                        Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                        Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                        asymptomatic replace as per above protocol

                                                                                                        Electrolyte Replacement Therapy Protocol

                                                                                                        bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                        bull IV repletion for severe and symptomatic hypokalemia

                                                                                                        Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                        ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                        عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                        صاف 2 عضالت انقباض

                                                                                                        هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                        انعقاد 4

                                                                                                        یونیزه Calt45 meql هيپوكلسمي

                                                                                                        عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                        ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                        میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                        ( شود می پیوند شده

                                                                                                        هیپوکلسمی عالئم

                                                                                                        رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                        سایرعالئم

                                                                                                        قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                        درمان

                                                                                                        ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                        Cagt55meql هيپركلسمي

                                                                                                        هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                        عالئم

                                                                                                        bullGI

                                                                                                        bullCardiovascular bullRenal (polyuria)

                                                                                                        bullCNS

                                                                                                        قلبی عالئم

                                                                                                        bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                        QRS شدن )Q-Tوكوتاه

                                                                                                        درمان

                                                                                                        ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                        الزیکس2

                                                                                                        تونین 3 کلسی

                                                                                                        کورتون4

                                                                                                        دیالیز5

                                                                                                        Magnesium Abnormalities

                                                                                                        Normal dietary intake 20meq (240mg)

                                                                                                        Excretion in both the feces and urine

                                                                                                        Normal serum level 19-25 mgdL

                                                                                                        منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                        تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                        bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                        Hypermagnesemia

                                                                                                        Etiology

                                                                                                        1 Impaired renal function

                                                                                                        2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                        Clinical manifestation hypermanesemia

                                                                                                        System hypermanesemia

                                                                                                        Gastrointestinal Nauseavomiting

                                                                                                        Neuromuscular weakness lethargy Decreased

                                                                                                        reflexes

                                                                                                        Cardiovascular Hypotension arrest

                                                                                                        ECG changes Increased PR interval

                                                                                                        Widened QRS complex

                                                                                                        Elevated T waves

                                                                                                        Treatment

                                                                                                        1 Withhold exogenous sources of magnesium

                                                                                                        2 Correct volume deficit

                                                                                                        3 Correct acidosis if present

                                                                                                        4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                        5 Dialysis (if elevated levels or symptoms persist)

                                                                                                        عالئم

                                                                                                        bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                        meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                        meqL

                                                                                                        Hypomagnesemia

                                                                                                        Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                        homeostasis

                                                                                                        Etiology

                                                                                                        1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                        inadequate supplementation of magnesium)

                                                                                                        2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                        3 GI losses (diarrhea)

                                                                                                        4 Malabsorption

                                                                                                        5 Acute pancreatitis

                                                                                                        6 Diabetic ketoacidosis

                                                                                                        7 Primary aldosteronism

                                                                                                        Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                        1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                        2 Delirium and seizures in severe deficiency

                                                                                                        3 ECG changes Prolonged QT and PR interval

                                                                                                        ST-segment depression

                                                                                                        Flattening or inversion of P waves

                                                                                                        Torsades de pointes

                                                                                                        Arrhythmia

                                                                                                        Treatment

                                                                                                        1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                        2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                        Message for Today

                                                                                                        ICF

                                                                                                        Interstitial

                                                                                                        Pla

                                                                                                        sma

                                                                                                        5 Dex

                                                                                                        bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                        • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                        • Slide 2
                                                                                                        • Slide 3
                                                                                                        • Slide 4
                                                                                                        • Total Body Water
                                                                                                        • Body Fluid Compartments
                                                                                                        • Total body water (TBW)
                                                                                                        • Body compartment fluid
                                                                                                        • Example men with 70kg
                                                                                                        • Fluid compartments
                                                                                                        • Slide 11
                                                                                                        • Slide 12
                                                                                                        • Slide 13
                                                                                                        • Slide 14
                                                                                                        • Slide 15
                                                                                                        • Colloid osmotic pressure
                                                                                                        • Slide 17
                                                                                                        • Slide 18
                                                                                                        • Slide 19
                                                                                                        • Cell Membrane
                                                                                                        • Slide 21
                                                                                                        • Slide 22
                                                                                                        • Slide 23
                                                                                                        • Slide 24
                                                                                                        • Slide 25
                                                                                                        • Composition of Fluid Compartments
                                                                                                        • Composition of Body Fluids
                                                                                                        • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                        • Reasons for fluid therapy
                                                                                                        • ارزیابی حجم مایع داخل عروقی
                                                                                                        • محلولهای وریدی
                                                                                                        • Fluids
                                                                                                        • Slide 33
                                                                                                        • Slide 34
                                                                                                        • Slide 35
                                                                                                        • Crystalloids
                                                                                                        • Colloid Solutions
                                                                                                        • رینگر لاکتات
                                                                                                        • 09Nacl
                                                                                                        • Postoperative (maintenance)
                                                                                                        • Slide 41
                                                                                                        • Preexisting fluid deficits
                                                                                                        • Maintenance requirements
                                                                                                        • Surgical fluid losses
                                                                                                        • Third space loss
                                                                                                        • Crystalloid solution
                                                                                                        • Colloids
                                                                                                        • Complications
                                                                                                        • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                        • Colloid versus crystalloid solutions
                                                                                                        • Transfusion consideration
                                                                                                        • اختلال در حجم مایعات بدن
                                                                                                        • Fluid volume deficit (FVD)
                                                                                                        • DEHYDRATION
                                                                                                        • علل کاهش حجم خارج سلولی
                                                                                                        • Signs of Hypovolemia
                                                                                                        • Clinical Diagnosis of Hypovolemia
                                                                                                        • Signs of Hypervolemia
                                                                                                        • Management of Hypervolemia
                                                                                                        • Fluid Management
                                                                                                        • Electrolyte physiology
                                                                                                        • Sodium physiology
                                                                                                        • Osmotic Pressure
                                                                                                        • Concentration
                                                                                                        • Hypernatremia
                                                                                                        • - Hypernatremia
                                                                                                        • Slide 67
                                                                                                        • Slide 68
                                                                                                        • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                        • Treatment
                                                                                                        • Water deficit (L)= times TBW
                                                                                                        • The rate of fluid administration
                                                                                                        • Hyponatremia Nalt135mEqL
                                                                                                        • Slide 74
                                                                                                        • Sodium depletion
                                                                                                        • Sodium dilution
                                                                                                        • Sign and symptoms
                                                                                                        • Slide 78
                                                                                                        • Treatment
                                                                                                        • Slide 80
                                                                                                        • Slide 81
                                                                                                        • Dose
                                                                                                        • Potassium abnormalities
                                                                                                        • Hyperkalemia
                                                                                                        • Clinical manifestation of hyperkalemia
                                                                                                        • Slide 86
                                                                                                        • Slide 87
                                                                                                        • Hypokalemia
                                                                                                        • Potassium changes associated with alkalosis
                                                                                                        • Slide 90
                                                                                                        • Clinical Manifestation of Abnormalities in potassium
                                                                                                        • Slide 92
                                                                                                        • Calcium
                                                                                                        • هيپوكلسمي یونیزه Calt45 meql
                                                                                                        • علائم هیپوکلسمی
                                                                                                        • Slide 96
                                                                                                        • Slide 97
                                                                                                        • Slide 98
                                                                                                        • Slide 99
                                                                                                        • سایرعلائم
                                                                                                        • درمان
                                                                                                        • هيپركلسمي Cagt55meql
                                                                                                        • علائم
                                                                                                        • علائم قلبی
                                                                                                        • Slide 105
                                                                                                        • Magnesium Abnormalities
                                                                                                        • منیزیوم
                                                                                                        • Hypermagnesemia
                                                                                                        • Clinical manifestation hypermanesemia
                                                                                                        • Slide 110
                                                                                                        • Slide 111
                                                                                                        • Hypomagnesemia
                                                                                                        • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                        • Slide 114
                                                                                                        • Message for Today
                                                                                                        • Slide 116

                                                                                                          DEHYDRATION

                                                                                                          سدیم bull افزایش با همراه آب کاهش دهیدریشن در دارد وجود سرمی

                                                                                                          سلولی خارج حجم کاهش علل

                                                                                                          1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                                                          2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                                                          کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                                                          Signs of HypovolemiaSigns of Hypovolemia

                                                                                                          bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                                                          Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                                                          bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                                                          Signs of HypervolemiaSigns of Hypervolemia

                                                                                                          bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                                                          Especially when hypo-albuminemia

                                                                                                          Management of Management of HypervolemiaHypervolemia

                                                                                                          bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                                                          Fluid ManagementFluid Management

                                                                                                          bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                                          Electrolyte physiology

                                                                                                          Sodium physiology

                                                                                                          Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                                          Normal amount 135-145 meql

                                                                                                          Osmotic Pressure

                                                                                                          Calculated serum osmolality =

                                                                                                          2 sodium+ glucose18 + BUN 28

                                                                                                          Osmolality = 290 mosm

                                                                                                          Concentration

                                                                                                          1Serum sodium concentration2Serum osmolarity

                                                                                                          bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                                          drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                                          DW5)

                                                                                                          Hypernatremia

                                                                                                          Serum Nagt145mEqL

                                                                                                          - Hypernatremia

                                                                                                          Loss of Free Water

                                                                                                          Gain of sodium in excess of water

                                                                                                          Hypernatremia

                                                                                                          -Hypernatremia Hypo volemic

                                                                                                          Hyper volemic

                                                                                                          Normo volemic

                                                                                                          Hypernatremia

                                                                                                          Volume Status

                                                                                                          Normal

                                                                                                          Nonrenal water loss

                                                                                                          Skin

                                                                                                          Gastrointestinal

                                                                                                          Renal water loss

                                                                                                          Renal disease

                                                                                                          Diuretics

                                                                                                          Diabetes insipidus

                                                                                                          High

                                                                                                          Iatrogenic sodium administration

                                                                                                          Mineralocorticoid excess

                                                                                                          Aldosteronism

                                                                                                          Cushingrsquos disease

                                                                                                          Congenital adrenal

                                                                                                          hyperplasia

                                                                                                          Low

                                                                                                          Nonrenal water loss

                                                                                                          Skin

                                                                                                          Gastrointestinal losses

                                                                                                          Renal water losses

                                                                                                          Renal (tubular) Diuretics

                                                                                                          Osmotic diuretics

                                                                                                          Diabetes insipidus

                                                                                                          Adrenal failure

                                                                                                          Asymptomatic

                                                                                                          Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                          Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                          Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                          Body system hypernatremia

                                                                                                          Treatment

                                                                                                          Normal saline in hypovolemic patients

                                                                                                          Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                          saline or entral water)

                                                                                                          Water deficit (L)= times TBW

                                                                                                          The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                          Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                          Serum sodium-140

                                                                                                          140

                                                                                                          The rate of fluid administration

                                                                                                          1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                          2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                          Hyponatremia Nalt135mEqL

                                                                                                          Causes

                                                                                                          1 Sodium depletion

                                                                                                          2 Sodium dilution

                                                                                                          bull Incidence = 45

                                                                                                          bull After surgery=1

                                                                                                          bull Mortality = 2 times normal

                                                                                                          Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                          volume deficit

                                                                                                          Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                          Sign and symptoms

                                                                                                          bull CNS symptom when Nalt123 meql

                                                                                                          bull Cardiac symptom when Nalt100 meql

                                                                                                          For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                          Body System Hyponatremia

                                                                                                          central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                          reflexes seizures coma increased intracranial pressure

                                                                                                          Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                          Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                          Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                          intracranial pressure

                                                                                                          Tissue Lacrimation salivation

                                                                                                          Renal Oliguria

                                                                                                          Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                          Treatment

                                                                                                          1=Depend on ECF

                                                                                                          2=CNS sign

                                                                                                          Treatment

                                                                                                          1 Asymptomatic increase the sodium level by no more than

                                                                                                          05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                          2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                          more than 1meqL per hour until the serum Na level reaches 130

                                                                                                          meqL or neurologic symptoms are improved

                                                                                                          Rapid correction of hyponatremia

                                                                                                          Pontine myelinolysis

                                                                                                          Seizures weaknessparesis akinetic

                                                                                                          movements unresponsiveness

                                                                                                          Permanent brain damage

                                                                                                          Death

                                                                                                          Dose

                                                                                                          Na deficit meq =(140- Na meql) TBW

                                                                                                          باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                          شود اصالح آهسته سپس

                                                                                                          Potassium abnormalities

                                                                                                          bull The average dietary intake of potassium 50-100meqd

                                                                                                          bull The average renal excretion of potassium 10-700 meqd

                                                                                                          - 2 of the total body potassium in ECF (45meqL)

                                                                                                          - Factors that influence serum potassium

                                                                                                          1 Surgical stress

                                                                                                          2 Injury

                                                                                                          3 Acidosis

                                                                                                          4 Tissue catabolism

                                                                                                          Hyperkalemia

                                                                                                          The normal range of serum potassium 35-5 meqL

                                                                                                          Etiology of Hyperkalemia

                                                                                                          Increased intake Potassium supplementation

                                                                                                          Blood transfusions

                                                                                                          Endogenous loaddestruction

                                                                                                          hemolysis rhabdomyolysis

                                                                                                          cruch injury gastrointestinal hemorrhage

                                                                                                          Increased release Acidosis

                                                                                                          Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                          Renal insufficiencyfailure

                                                                                                          Clinical manifestation of hyperkalemia

                                                                                                          System hyperkalemia

                                                                                                          Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                          Neuromuscular weakness paralysis respiratory failure

                                                                                                          Cardiovascular Arrhythmia arrest

                                                                                                          ECG changes Peaked T waves (early change)

                                                                                                          Flattened P wave

                                                                                                          Prolonged PR interval (first-degree block)

                                                                                                          Widened QRS complex

                                                                                                          Sine wave formation

                                                                                                          Ventricular fibrillation

                                                                                                          Treatment

                                                                                                          Treatment of symptomatic hyperkalemia

                                                                                                          Potassium removal Kayexalate

                                                                                                          Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                          Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                          Dialysis

                                                                                                          Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                          Bicarbonate 1 vial intravenous

                                                                                                          Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                          HypokalemiaEtiology

                                                                                                          inadequate intake

                                                                                                          Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                          total parenteral nutrition

                                                                                                          Excessive potassium excretion

                                                                                                          Hyperaldosteronism

                                                                                                          Medications

                                                                                                          Gastrointestinal losses

                                                                                                          Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                          Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                          nasogastric output)

                                                                                                          Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                          Potassium changes associated with alkalosis

                                                                                                          Potassium decrease by 03 meqL for every 01

                                                                                                          increase in PH above normal

                                                                                                          Magnesium Depletion

                                                                                                          (drug induced amphotericin amioglycosides cisplatin)

                                                                                                          Renal potassium wastage

                                                                                                          Hypokalemia

                                                                                                          Magnesium Depletion

                                                                                                          (drug induced amphotericin amioglycosides cisplatin)

                                                                                                          Renal potassium wastage

                                                                                                          Hypokalemia

                                                                                                          Clinical Manifestation of Abnormalities in potassium

                                                                                                          System hypokalemia

                                                                                                          Gastrointestinal Ileus constipation

                                                                                                          Neuromuscular Decreased reflexes fatigue weakness

                                                                                                          paralysis

                                                                                                          Cardiovascular Arrest

                                                                                                          ECG changes U-waves

                                                                                                          T-wave flattening

                                                                                                          ST-segment changes

                                                                                                          Arrhythmias

                                                                                                          Treatment

                                                                                                          Potassium

                                                                                                          Serum potassium level lt40 mEqL

                                                                                                          Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                          times 1 doses

                                                                                                          Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                          Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                          Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                          asymptomatic replace as per above protocol

                                                                                                          Electrolyte Replacement Therapy Protocol

                                                                                                          bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                          bull IV repletion for severe and symptomatic hypokalemia

                                                                                                          Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                          ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                          عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                          صاف 2 عضالت انقباض

                                                                                                          هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                          انعقاد 4

                                                                                                          یونیزه Calt45 meql هيپوكلسمي

                                                                                                          عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                          ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                          میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                          ( شود می پیوند شده

                                                                                                          هیپوکلسمی عالئم

                                                                                                          رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                          سایرعالئم

                                                                                                          قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                          درمان

                                                                                                          ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                          Cagt55meql هيپركلسمي

                                                                                                          هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                          عالئم

                                                                                                          bullGI

                                                                                                          bullCardiovascular bullRenal (polyuria)

                                                                                                          bullCNS

                                                                                                          قلبی عالئم

                                                                                                          bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                          QRS شدن )Q-Tوكوتاه

                                                                                                          درمان

                                                                                                          ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                          الزیکس2

                                                                                                          تونین 3 کلسی

                                                                                                          کورتون4

                                                                                                          دیالیز5

                                                                                                          Magnesium Abnormalities

                                                                                                          Normal dietary intake 20meq (240mg)

                                                                                                          Excretion in both the feces and urine

                                                                                                          Normal serum level 19-25 mgdL

                                                                                                          منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                          تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                          bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                          Hypermagnesemia

                                                                                                          Etiology

                                                                                                          1 Impaired renal function

                                                                                                          2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                          Clinical manifestation hypermanesemia

                                                                                                          System hypermanesemia

                                                                                                          Gastrointestinal Nauseavomiting

                                                                                                          Neuromuscular weakness lethargy Decreased

                                                                                                          reflexes

                                                                                                          Cardiovascular Hypotension arrest

                                                                                                          ECG changes Increased PR interval

                                                                                                          Widened QRS complex

                                                                                                          Elevated T waves

                                                                                                          Treatment

                                                                                                          1 Withhold exogenous sources of magnesium

                                                                                                          2 Correct volume deficit

                                                                                                          3 Correct acidosis if present

                                                                                                          4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                          5 Dialysis (if elevated levels or symptoms persist)

                                                                                                          عالئم

                                                                                                          bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                          meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                          meqL

                                                                                                          Hypomagnesemia

                                                                                                          Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                          homeostasis

                                                                                                          Etiology

                                                                                                          1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                          inadequate supplementation of magnesium)

                                                                                                          2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                          3 GI losses (diarrhea)

                                                                                                          4 Malabsorption

                                                                                                          5 Acute pancreatitis

                                                                                                          6 Diabetic ketoacidosis

                                                                                                          7 Primary aldosteronism

                                                                                                          Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                          1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                          2 Delirium and seizures in severe deficiency

                                                                                                          3 ECG changes Prolonged QT and PR interval

                                                                                                          ST-segment depression

                                                                                                          Flattening or inversion of P waves

                                                                                                          Torsades de pointes

                                                                                                          Arrhythmia

                                                                                                          Treatment

                                                                                                          1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                          2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                          Message for Today

                                                                                                          ICF

                                                                                                          Interstitial

                                                                                                          Pla

                                                                                                          sma

                                                                                                          5 Dex

                                                                                                          bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                          • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                          • Slide 2
                                                                                                          • Slide 3
                                                                                                          • Slide 4
                                                                                                          • Total Body Water
                                                                                                          • Body Fluid Compartments
                                                                                                          • Total body water (TBW)
                                                                                                          • Body compartment fluid
                                                                                                          • Example men with 70kg
                                                                                                          • Fluid compartments
                                                                                                          • Slide 11
                                                                                                          • Slide 12
                                                                                                          • Slide 13
                                                                                                          • Slide 14
                                                                                                          • Slide 15
                                                                                                          • Colloid osmotic pressure
                                                                                                          • Slide 17
                                                                                                          • Slide 18
                                                                                                          • Slide 19
                                                                                                          • Cell Membrane
                                                                                                          • Slide 21
                                                                                                          • Slide 22
                                                                                                          • Slide 23
                                                                                                          • Slide 24
                                                                                                          • Slide 25
                                                                                                          • Composition of Fluid Compartments
                                                                                                          • Composition of Body Fluids
                                                                                                          • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                          • Reasons for fluid therapy
                                                                                                          • ارزیابی حجم مایع داخل عروقی
                                                                                                          • محلولهای وریدی
                                                                                                          • Fluids
                                                                                                          • Slide 33
                                                                                                          • Slide 34
                                                                                                          • Slide 35
                                                                                                          • Crystalloids
                                                                                                          • Colloid Solutions
                                                                                                          • رینگر لاکتات
                                                                                                          • 09Nacl
                                                                                                          • Postoperative (maintenance)
                                                                                                          • Slide 41
                                                                                                          • Preexisting fluid deficits
                                                                                                          • Maintenance requirements
                                                                                                          • Surgical fluid losses
                                                                                                          • Third space loss
                                                                                                          • Crystalloid solution
                                                                                                          • Colloids
                                                                                                          • Complications
                                                                                                          • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                          • Colloid versus crystalloid solutions
                                                                                                          • Transfusion consideration
                                                                                                          • اختلال در حجم مایعات بدن
                                                                                                          • Fluid volume deficit (FVD)
                                                                                                          • DEHYDRATION
                                                                                                          • علل کاهش حجم خارج سلولی
                                                                                                          • Signs of Hypovolemia
                                                                                                          • Clinical Diagnosis of Hypovolemia
                                                                                                          • Signs of Hypervolemia
                                                                                                          • Management of Hypervolemia
                                                                                                          • Fluid Management
                                                                                                          • Electrolyte physiology
                                                                                                          • Sodium physiology
                                                                                                          • Osmotic Pressure
                                                                                                          • Concentration
                                                                                                          • Hypernatremia
                                                                                                          • - Hypernatremia
                                                                                                          • Slide 67
                                                                                                          • Slide 68
                                                                                                          • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                          • Treatment
                                                                                                          • Water deficit (L)= times TBW
                                                                                                          • The rate of fluid administration
                                                                                                          • Hyponatremia Nalt135mEqL
                                                                                                          • Slide 74
                                                                                                          • Sodium depletion
                                                                                                          • Sodium dilution
                                                                                                          • Sign and symptoms
                                                                                                          • Slide 78
                                                                                                          • Treatment
                                                                                                          • Slide 80
                                                                                                          • Slide 81
                                                                                                          • Dose
                                                                                                          • Potassium abnormalities
                                                                                                          • Hyperkalemia
                                                                                                          • Clinical manifestation of hyperkalemia
                                                                                                          • Slide 86
                                                                                                          • Slide 87
                                                                                                          • Hypokalemia
                                                                                                          • Potassium changes associated with alkalosis
                                                                                                          • Slide 90
                                                                                                          • Clinical Manifestation of Abnormalities in potassium
                                                                                                          • Slide 92
                                                                                                          • Calcium
                                                                                                          • هيپوكلسمي یونیزه Calt45 meql
                                                                                                          • علائم هیپوکلسمی
                                                                                                          • Slide 96
                                                                                                          • Slide 97
                                                                                                          • Slide 98
                                                                                                          • Slide 99
                                                                                                          • سایرعلائم
                                                                                                          • درمان
                                                                                                          • هيپركلسمي Cagt55meql
                                                                                                          • علائم
                                                                                                          • علائم قلبی
                                                                                                          • Slide 105
                                                                                                          • Magnesium Abnormalities
                                                                                                          • منیزیوم
                                                                                                          • Hypermagnesemia
                                                                                                          • Clinical manifestation hypermanesemia
                                                                                                          • Slide 110
                                                                                                          • Slide 111
                                                                                                          • Hypomagnesemia
                                                                                                          • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                          • Slide 114
                                                                                                          • Message for Today
                                                                                                          • Slide 116

                                                                                                            سلولی خارج حجم کاهش علل

                                                                                                            1ndash استفراغ بدن آب طبیعی غیر دادن دست ازNGTتعریق--اسهال-

                                                                                                            2 ناتوانی یا تهوع بدن آب دریافت میزان کاهشمایعات به دسترسی

                                                                                                            کاردیواسکوالر (3 سیستم از مایعات thirdخروجspace loss ndash (جراحی ترومای سوختگی مثل

                                                                                                            Signs of HypovolemiaSigns of Hypovolemia

                                                                                                            bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                                                            Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                                                            bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                                                            Signs of HypervolemiaSigns of Hypervolemia

                                                                                                            bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                                                            Especially when hypo-albuminemia

                                                                                                            Management of Management of HypervolemiaHypervolemia

                                                                                                            bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                                                            Fluid ManagementFluid Management

                                                                                                            bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                                            Electrolyte physiology

                                                                                                            Sodium physiology

                                                                                                            Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                                            Normal amount 135-145 meql

                                                                                                            Osmotic Pressure

                                                                                                            Calculated serum osmolality =

                                                                                                            2 sodium+ glucose18 + BUN 28

                                                                                                            Osmolality = 290 mosm

                                                                                                            Concentration

                                                                                                            1Serum sodium concentration2Serum osmolarity

                                                                                                            bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                                            drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                                            DW5)

                                                                                                            Hypernatremia

                                                                                                            Serum Nagt145mEqL

                                                                                                            - Hypernatremia

                                                                                                            Loss of Free Water

                                                                                                            Gain of sodium in excess of water

                                                                                                            Hypernatremia

                                                                                                            -Hypernatremia Hypo volemic

                                                                                                            Hyper volemic

                                                                                                            Normo volemic

                                                                                                            Hypernatremia

                                                                                                            Volume Status

                                                                                                            Normal

                                                                                                            Nonrenal water loss

                                                                                                            Skin

                                                                                                            Gastrointestinal

                                                                                                            Renal water loss

                                                                                                            Renal disease

                                                                                                            Diuretics

                                                                                                            Diabetes insipidus

                                                                                                            High

                                                                                                            Iatrogenic sodium administration

                                                                                                            Mineralocorticoid excess

                                                                                                            Aldosteronism

                                                                                                            Cushingrsquos disease

                                                                                                            Congenital adrenal

                                                                                                            hyperplasia

                                                                                                            Low

                                                                                                            Nonrenal water loss

                                                                                                            Skin

                                                                                                            Gastrointestinal losses

                                                                                                            Renal water losses

                                                                                                            Renal (tubular) Diuretics

                                                                                                            Osmotic diuretics

                                                                                                            Diabetes insipidus

                                                                                                            Adrenal failure

                                                                                                            Asymptomatic

                                                                                                            Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                            Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                            Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                            Body system hypernatremia

                                                                                                            Treatment

                                                                                                            Normal saline in hypovolemic patients

                                                                                                            Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                            saline or entral water)

                                                                                                            Water deficit (L)= times TBW

                                                                                                            The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                            Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                            Serum sodium-140

                                                                                                            140

                                                                                                            The rate of fluid administration

                                                                                                            1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                            2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                            Hyponatremia Nalt135mEqL

                                                                                                            Causes

                                                                                                            1 Sodium depletion

                                                                                                            2 Sodium dilution

                                                                                                            bull Incidence = 45

                                                                                                            bull After surgery=1

                                                                                                            bull Mortality = 2 times normal

                                                                                                            Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                            volume deficit

                                                                                                            Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                            Sign and symptoms

                                                                                                            bull CNS symptom when Nalt123 meql

                                                                                                            bull Cardiac symptom when Nalt100 meql

                                                                                                            For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                            Body System Hyponatremia

                                                                                                            central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                            reflexes seizures coma increased intracranial pressure

                                                                                                            Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                            Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                            Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                            intracranial pressure

                                                                                                            Tissue Lacrimation salivation

                                                                                                            Renal Oliguria

                                                                                                            Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                            Treatment

                                                                                                            1=Depend on ECF

                                                                                                            2=CNS sign

                                                                                                            Treatment

                                                                                                            1 Asymptomatic increase the sodium level by no more than

                                                                                                            05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                            2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                            more than 1meqL per hour until the serum Na level reaches 130

                                                                                                            meqL or neurologic symptoms are improved

                                                                                                            Rapid correction of hyponatremia

                                                                                                            Pontine myelinolysis

                                                                                                            Seizures weaknessparesis akinetic

                                                                                                            movements unresponsiveness

                                                                                                            Permanent brain damage

                                                                                                            Death

                                                                                                            Dose

                                                                                                            Na deficit meq =(140- Na meql) TBW

                                                                                                            باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                            شود اصالح آهسته سپس

                                                                                                            Potassium abnormalities

                                                                                                            bull The average dietary intake of potassium 50-100meqd

                                                                                                            bull The average renal excretion of potassium 10-700 meqd

                                                                                                            - 2 of the total body potassium in ECF (45meqL)

                                                                                                            - Factors that influence serum potassium

                                                                                                            1 Surgical stress

                                                                                                            2 Injury

                                                                                                            3 Acidosis

                                                                                                            4 Tissue catabolism

                                                                                                            Hyperkalemia

                                                                                                            The normal range of serum potassium 35-5 meqL

                                                                                                            Etiology of Hyperkalemia

                                                                                                            Increased intake Potassium supplementation

                                                                                                            Blood transfusions

                                                                                                            Endogenous loaddestruction

                                                                                                            hemolysis rhabdomyolysis

                                                                                                            cruch injury gastrointestinal hemorrhage

                                                                                                            Increased release Acidosis

                                                                                                            Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                            Renal insufficiencyfailure

                                                                                                            Clinical manifestation of hyperkalemia

                                                                                                            System hyperkalemia

                                                                                                            Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                            Neuromuscular weakness paralysis respiratory failure

                                                                                                            Cardiovascular Arrhythmia arrest

                                                                                                            ECG changes Peaked T waves (early change)

                                                                                                            Flattened P wave

                                                                                                            Prolonged PR interval (first-degree block)

                                                                                                            Widened QRS complex

                                                                                                            Sine wave formation

                                                                                                            Ventricular fibrillation

                                                                                                            Treatment

                                                                                                            Treatment of symptomatic hyperkalemia

                                                                                                            Potassium removal Kayexalate

                                                                                                            Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                            Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                            Dialysis

                                                                                                            Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                            Bicarbonate 1 vial intravenous

                                                                                                            Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                            HypokalemiaEtiology

                                                                                                            inadequate intake

                                                                                                            Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                            total parenteral nutrition

                                                                                                            Excessive potassium excretion

                                                                                                            Hyperaldosteronism

                                                                                                            Medications

                                                                                                            Gastrointestinal losses

                                                                                                            Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                            Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                            nasogastric output)

                                                                                                            Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                            Potassium changes associated with alkalosis

                                                                                                            Potassium decrease by 03 meqL for every 01

                                                                                                            increase in PH above normal

                                                                                                            Magnesium Depletion

                                                                                                            (drug induced amphotericin amioglycosides cisplatin)

                                                                                                            Renal potassium wastage

                                                                                                            Hypokalemia

                                                                                                            Magnesium Depletion

                                                                                                            (drug induced amphotericin amioglycosides cisplatin)

                                                                                                            Renal potassium wastage

                                                                                                            Hypokalemia

                                                                                                            Clinical Manifestation of Abnormalities in potassium

                                                                                                            System hypokalemia

                                                                                                            Gastrointestinal Ileus constipation

                                                                                                            Neuromuscular Decreased reflexes fatigue weakness

                                                                                                            paralysis

                                                                                                            Cardiovascular Arrest

                                                                                                            ECG changes U-waves

                                                                                                            T-wave flattening

                                                                                                            ST-segment changes

                                                                                                            Arrhythmias

                                                                                                            Treatment

                                                                                                            Potassium

                                                                                                            Serum potassium level lt40 mEqL

                                                                                                            Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                            times 1 doses

                                                                                                            Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                            Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                            Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                            asymptomatic replace as per above protocol

                                                                                                            Electrolyte Replacement Therapy Protocol

                                                                                                            bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                            bull IV repletion for severe and symptomatic hypokalemia

                                                                                                            Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                            ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                            عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                            صاف 2 عضالت انقباض

                                                                                                            هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                            انعقاد 4

                                                                                                            یونیزه Calt45 meql هيپوكلسمي

                                                                                                            عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                            ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                            میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                            ( شود می پیوند شده

                                                                                                            هیپوکلسمی عالئم

                                                                                                            رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                            سایرعالئم

                                                                                                            قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                            درمان

                                                                                                            ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                            Cagt55meql هيپركلسمي

                                                                                                            هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                            عالئم

                                                                                                            bullGI

                                                                                                            bullCardiovascular bullRenal (polyuria)

                                                                                                            bullCNS

                                                                                                            قلبی عالئم

                                                                                                            bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                            QRS شدن )Q-Tوكوتاه

                                                                                                            درمان

                                                                                                            ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                            الزیکس2

                                                                                                            تونین 3 کلسی

                                                                                                            کورتون4

                                                                                                            دیالیز5

                                                                                                            Magnesium Abnormalities

                                                                                                            Normal dietary intake 20meq (240mg)

                                                                                                            Excretion in both the feces and urine

                                                                                                            Normal serum level 19-25 mgdL

                                                                                                            منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                            تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                            bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                            Hypermagnesemia

                                                                                                            Etiology

                                                                                                            1 Impaired renal function

                                                                                                            2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                            Clinical manifestation hypermanesemia

                                                                                                            System hypermanesemia

                                                                                                            Gastrointestinal Nauseavomiting

                                                                                                            Neuromuscular weakness lethargy Decreased

                                                                                                            reflexes

                                                                                                            Cardiovascular Hypotension arrest

                                                                                                            ECG changes Increased PR interval

                                                                                                            Widened QRS complex

                                                                                                            Elevated T waves

                                                                                                            Treatment

                                                                                                            1 Withhold exogenous sources of magnesium

                                                                                                            2 Correct volume deficit

                                                                                                            3 Correct acidosis if present

                                                                                                            4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                            5 Dialysis (if elevated levels or symptoms persist)

                                                                                                            عالئم

                                                                                                            bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                            meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                            meqL

                                                                                                            Hypomagnesemia

                                                                                                            Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                            homeostasis

                                                                                                            Etiology

                                                                                                            1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                            inadequate supplementation of magnesium)

                                                                                                            2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                            3 GI losses (diarrhea)

                                                                                                            4 Malabsorption

                                                                                                            5 Acute pancreatitis

                                                                                                            6 Diabetic ketoacidosis

                                                                                                            7 Primary aldosteronism

                                                                                                            Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                            1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                            2 Delirium and seizures in severe deficiency

                                                                                                            3 ECG changes Prolonged QT and PR interval

                                                                                                            ST-segment depression

                                                                                                            Flattening or inversion of P waves

                                                                                                            Torsades de pointes

                                                                                                            Arrhythmia

                                                                                                            Treatment

                                                                                                            1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                            2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                            Message for Today

                                                                                                            ICF

                                                                                                            Interstitial

                                                                                                            Pla

                                                                                                            sma

                                                                                                            5 Dex

                                                                                                            bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                            • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                            • Slide 2
                                                                                                            • Slide 3
                                                                                                            • Slide 4
                                                                                                            • Total Body Water
                                                                                                            • Body Fluid Compartments
                                                                                                            • Total body water (TBW)
                                                                                                            • Body compartment fluid
                                                                                                            • Example men with 70kg
                                                                                                            • Fluid compartments
                                                                                                            • Slide 11
                                                                                                            • Slide 12
                                                                                                            • Slide 13
                                                                                                            • Slide 14
                                                                                                            • Slide 15
                                                                                                            • Colloid osmotic pressure
                                                                                                            • Slide 17
                                                                                                            • Slide 18
                                                                                                            • Slide 19
                                                                                                            • Cell Membrane
                                                                                                            • Slide 21
                                                                                                            • Slide 22
                                                                                                            • Slide 23
                                                                                                            • Slide 24
                                                                                                            • Slide 25
                                                                                                            • Composition of Fluid Compartments
                                                                                                            • Composition of Body Fluids
                                                                                                            • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                            • Reasons for fluid therapy
                                                                                                            • ارزیابی حجم مایع داخل عروقی
                                                                                                            • محلولهای وریدی
                                                                                                            • Fluids
                                                                                                            • Slide 33
                                                                                                            • Slide 34
                                                                                                            • Slide 35
                                                                                                            • Crystalloids
                                                                                                            • Colloid Solutions
                                                                                                            • رینگر لاکتات
                                                                                                            • 09Nacl
                                                                                                            • Postoperative (maintenance)
                                                                                                            • Slide 41
                                                                                                            • Preexisting fluid deficits
                                                                                                            • Maintenance requirements
                                                                                                            • Surgical fluid losses
                                                                                                            • Third space loss
                                                                                                            • Crystalloid solution
                                                                                                            • Colloids
                                                                                                            • Complications
                                                                                                            • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                            • Colloid versus crystalloid solutions
                                                                                                            • Transfusion consideration
                                                                                                            • اختلال در حجم مایعات بدن
                                                                                                            • Fluid volume deficit (FVD)
                                                                                                            • DEHYDRATION
                                                                                                            • علل کاهش حجم خارج سلولی
                                                                                                            • Signs of Hypovolemia
                                                                                                            • Clinical Diagnosis of Hypovolemia
                                                                                                            • Signs of Hypervolemia
                                                                                                            • Management of Hypervolemia
                                                                                                            • Fluid Management
                                                                                                            • Electrolyte physiology
                                                                                                            • Sodium physiology
                                                                                                            • Osmotic Pressure
                                                                                                            • Concentration
                                                                                                            • Hypernatremia
                                                                                                            • - Hypernatremia
                                                                                                            • Slide 67
                                                                                                            • Slide 68
                                                                                                            • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                            • Treatment
                                                                                                            • Water deficit (L)= times TBW
                                                                                                            • The rate of fluid administration
                                                                                                            • Hyponatremia Nalt135mEqL
                                                                                                            • Slide 74
                                                                                                            • Sodium depletion
                                                                                                            • Sodium dilution
                                                                                                            • Sign and symptoms
                                                                                                            • Slide 78
                                                                                                            • Treatment
                                                                                                            • Slide 80
                                                                                                            • Slide 81
                                                                                                            • Dose
                                                                                                            • Potassium abnormalities
                                                                                                            • Hyperkalemia
                                                                                                            • Clinical manifestation of hyperkalemia
                                                                                                            • Slide 86
                                                                                                            • Slide 87
                                                                                                            • Hypokalemia
                                                                                                            • Potassium changes associated with alkalosis
                                                                                                            • Slide 90
                                                                                                            • Clinical Manifestation of Abnormalities in potassium
                                                                                                            • Slide 92
                                                                                                            • Calcium
                                                                                                            • هيپوكلسمي یونیزه Calt45 meql
                                                                                                            • علائم هیپوکلسمی
                                                                                                            • Slide 96
                                                                                                            • Slide 97
                                                                                                            • Slide 98
                                                                                                            • Slide 99
                                                                                                            • سایرعلائم
                                                                                                            • درمان
                                                                                                            • هيپركلسمي Cagt55meql
                                                                                                            • علائم
                                                                                                            • علائم قلبی
                                                                                                            • Slide 105
                                                                                                            • Magnesium Abnormalities
                                                                                                            • منیزیوم
                                                                                                            • Hypermagnesemia
                                                                                                            • Clinical manifestation hypermanesemia
                                                                                                            • Slide 110
                                                                                                            • Slide 111
                                                                                                            • Hypomagnesemia
                                                                                                            • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                            • Slide 114
                                                                                                            • Message for Today
                                                                                                            • Slide 116

                                                                                                              Signs of HypovolemiaSigns of Hypovolemia

                                                                                                              bull Diminished skin turgorbull Dry oral mucus membranebull Oliguria - lt500mlday - normal 05~1mlkghbull Tachycardiabull Hypotensionbull Hypoperfusioncyanosisbull Altered mental status

                                                                                                              Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                                                              bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                                                              Signs of HypervolemiaSigns of Hypervolemia

                                                                                                              bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                                                              Especially when hypo-albuminemia

                                                                                                              Management of Management of HypervolemiaHypervolemia

                                                                                                              bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                                                              Fluid ManagementFluid Management

                                                                                                              bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                                              Electrolyte physiology

                                                                                                              Sodium physiology

                                                                                                              Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                                              Normal amount 135-145 meql

                                                                                                              Osmotic Pressure

                                                                                                              Calculated serum osmolality =

                                                                                                              2 sodium+ glucose18 + BUN 28

                                                                                                              Osmolality = 290 mosm

                                                                                                              Concentration

                                                                                                              1Serum sodium concentration2Serum osmolarity

                                                                                                              bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                                              drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                                              DW5)

                                                                                                              Hypernatremia

                                                                                                              Serum Nagt145mEqL

                                                                                                              - Hypernatremia

                                                                                                              Loss of Free Water

                                                                                                              Gain of sodium in excess of water

                                                                                                              Hypernatremia

                                                                                                              -Hypernatremia Hypo volemic

                                                                                                              Hyper volemic

                                                                                                              Normo volemic

                                                                                                              Hypernatremia

                                                                                                              Volume Status

                                                                                                              Normal

                                                                                                              Nonrenal water loss

                                                                                                              Skin

                                                                                                              Gastrointestinal

                                                                                                              Renal water loss

                                                                                                              Renal disease

                                                                                                              Diuretics

                                                                                                              Diabetes insipidus

                                                                                                              High

                                                                                                              Iatrogenic sodium administration

                                                                                                              Mineralocorticoid excess

                                                                                                              Aldosteronism

                                                                                                              Cushingrsquos disease

                                                                                                              Congenital adrenal

                                                                                                              hyperplasia

                                                                                                              Low

                                                                                                              Nonrenal water loss

                                                                                                              Skin

                                                                                                              Gastrointestinal losses

                                                                                                              Renal water losses

                                                                                                              Renal (tubular) Diuretics

                                                                                                              Osmotic diuretics

                                                                                                              Diabetes insipidus

                                                                                                              Adrenal failure

                                                                                                              Asymptomatic

                                                                                                              Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                              Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                              Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                              Body system hypernatremia

                                                                                                              Treatment

                                                                                                              Normal saline in hypovolemic patients

                                                                                                              Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                              saline or entral water)

                                                                                                              Water deficit (L)= times TBW

                                                                                                              The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                              Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                              Serum sodium-140

                                                                                                              140

                                                                                                              The rate of fluid administration

                                                                                                              1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                              2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                              Hyponatremia Nalt135mEqL

                                                                                                              Causes

                                                                                                              1 Sodium depletion

                                                                                                              2 Sodium dilution

                                                                                                              bull Incidence = 45

                                                                                                              bull After surgery=1

                                                                                                              bull Mortality = 2 times normal

                                                                                                              Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                              volume deficit

                                                                                                              Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                              Sign and symptoms

                                                                                                              bull CNS symptom when Nalt123 meql

                                                                                                              bull Cardiac symptom when Nalt100 meql

                                                                                                              For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                              Body System Hyponatremia

                                                                                                              central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                              reflexes seizures coma increased intracranial pressure

                                                                                                              Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                              Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                              Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                              intracranial pressure

                                                                                                              Tissue Lacrimation salivation

                                                                                                              Renal Oliguria

                                                                                                              Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                              Treatment

                                                                                                              1=Depend on ECF

                                                                                                              2=CNS sign

                                                                                                              Treatment

                                                                                                              1 Asymptomatic increase the sodium level by no more than

                                                                                                              05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                              2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                              more than 1meqL per hour until the serum Na level reaches 130

                                                                                                              meqL or neurologic symptoms are improved

                                                                                                              Rapid correction of hyponatremia

                                                                                                              Pontine myelinolysis

                                                                                                              Seizures weaknessparesis akinetic

                                                                                                              movements unresponsiveness

                                                                                                              Permanent brain damage

                                                                                                              Death

                                                                                                              Dose

                                                                                                              Na deficit meq =(140- Na meql) TBW

                                                                                                              باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                              شود اصالح آهسته سپس

                                                                                                              Potassium abnormalities

                                                                                                              bull The average dietary intake of potassium 50-100meqd

                                                                                                              bull The average renal excretion of potassium 10-700 meqd

                                                                                                              - 2 of the total body potassium in ECF (45meqL)

                                                                                                              - Factors that influence serum potassium

                                                                                                              1 Surgical stress

                                                                                                              2 Injury

                                                                                                              3 Acidosis

                                                                                                              4 Tissue catabolism

                                                                                                              Hyperkalemia

                                                                                                              The normal range of serum potassium 35-5 meqL

                                                                                                              Etiology of Hyperkalemia

                                                                                                              Increased intake Potassium supplementation

                                                                                                              Blood transfusions

                                                                                                              Endogenous loaddestruction

                                                                                                              hemolysis rhabdomyolysis

                                                                                                              cruch injury gastrointestinal hemorrhage

                                                                                                              Increased release Acidosis

                                                                                                              Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                              Renal insufficiencyfailure

                                                                                                              Clinical manifestation of hyperkalemia

                                                                                                              System hyperkalemia

                                                                                                              Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                              Neuromuscular weakness paralysis respiratory failure

                                                                                                              Cardiovascular Arrhythmia arrest

                                                                                                              ECG changes Peaked T waves (early change)

                                                                                                              Flattened P wave

                                                                                                              Prolonged PR interval (first-degree block)

                                                                                                              Widened QRS complex

                                                                                                              Sine wave formation

                                                                                                              Ventricular fibrillation

                                                                                                              Treatment

                                                                                                              Treatment of symptomatic hyperkalemia

                                                                                                              Potassium removal Kayexalate

                                                                                                              Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                              Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                              Dialysis

                                                                                                              Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                              Bicarbonate 1 vial intravenous

                                                                                                              Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                              HypokalemiaEtiology

                                                                                                              inadequate intake

                                                                                                              Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                              total parenteral nutrition

                                                                                                              Excessive potassium excretion

                                                                                                              Hyperaldosteronism

                                                                                                              Medications

                                                                                                              Gastrointestinal losses

                                                                                                              Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                              Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                              nasogastric output)

                                                                                                              Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                              Potassium changes associated with alkalosis

                                                                                                              Potassium decrease by 03 meqL for every 01

                                                                                                              increase in PH above normal

                                                                                                              Magnesium Depletion

                                                                                                              (drug induced amphotericin amioglycosides cisplatin)

                                                                                                              Renal potassium wastage

                                                                                                              Hypokalemia

                                                                                                              Magnesium Depletion

                                                                                                              (drug induced amphotericin amioglycosides cisplatin)

                                                                                                              Renal potassium wastage

                                                                                                              Hypokalemia

                                                                                                              Clinical Manifestation of Abnormalities in potassium

                                                                                                              System hypokalemia

                                                                                                              Gastrointestinal Ileus constipation

                                                                                                              Neuromuscular Decreased reflexes fatigue weakness

                                                                                                              paralysis

                                                                                                              Cardiovascular Arrest

                                                                                                              ECG changes U-waves

                                                                                                              T-wave flattening

                                                                                                              ST-segment changes

                                                                                                              Arrhythmias

                                                                                                              Treatment

                                                                                                              Potassium

                                                                                                              Serum potassium level lt40 mEqL

                                                                                                              Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                              times 1 doses

                                                                                                              Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                              Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                              Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                              asymptomatic replace as per above protocol

                                                                                                              Electrolyte Replacement Therapy Protocol

                                                                                                              bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                              bull IV repletion for severe and symptomatic hypokalemia

                                                                                                              Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                              ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                              عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                              صاف 2 عضالت انقباض

                                                                                                              هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                              انعقاد 4

                                                                                                              یونیزه Calt45 meql هيپوكلسمي

                                                                                                              عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                              ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                              میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                              ( شود می پیوند شده

                                                                                                              هیپوکلسمی عالئم

                                                                                                              رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                              سایرعالئم

                                                                                                              قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                              درمان

                                                                                                              ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                              Cagt55meql هيپركلسمي

                                                                                                              هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                              عالئم

                                                                                                              bullGI

                                                                                                              bullCardiovascular bullRenal (polyuria)

                                                                                                              bullCNS

                                                                                                              قلبی عالئم

                                                                                                              bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                              QRS شدن )Q-Tوكوتاه

                                                                                                              درمان

                                                                                                              ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                              الزیکس2

                                                                                                              تونین 3 کلسی

                                                                                                              کورتون4

                                                                                                              دیالیز5

                                                                                                              Magnesium Abnormalities

                                                                                                              Normal dietary intake 20meq (240mg)

                                                                                                              Excretion in both the feces and urine

                                                                                                              Normal serum level 19-25 mgdL

                                                                                                              منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                              تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                              bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                              Hypermagnesemia

                                                                                                              Etiology

                                                                                                              1 Impaired renal function

                                                                                                              2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                              Clinical manifestation hypermanesemia

                                                                                                              System hypermanesemia

                                                                                                              Gastrointestinal Nauseavomiting

                                                                                                              Neuromuscular weakness lethargy Decreased

                                                                                                              reflexes

                                                                                                              Cardiovascular Hypotension arrest

                                                                                                              ECG changes Increased PR interval

                                                                                                              Widened QRS complex

                                                                                                              Elevated T waves

                                                                                                              Treatment

                                                                                                              1 Withhold exogenous sources of magnesium

                                                                                                              2 Correct volume deficit

                                                                                                              3 Correct acidosis if present

                                                                                                              4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                              5 Dialysis (if elevated levels or symptoms persist)

                                                                                                              عالئم

                                                                                                              bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                              meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                              meqL

                                                                                                              Hypomagnesemia

                                                                                                              Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                              homeostasis

                                                                                                              Etiology

                                                                                                              1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                              inadequate supplementation of magnesium)

                                                                                                              2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                              3 GI losses (diarrhea)

                                                                                                              4 Malabsorption

                                                                                                              5 Acute pancreatitis

                                                                                                              6 Diabetic ketoacidosis

                                                                                                              7 Primary aldosteronism

                                                                                                              Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                              1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                              2 Delirium and seizures in severe deficiency

                                                                                                              3 ECG changes Prolonged QT and PR interval

                                                                                                              ST-segment depression

                                                                                                              Flattening or inversion of P waves

                                                                                                              Torsades de pointes

                                                                                                              Arrhythmia

                                                                                                              Treatment

                                                                                                              1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                              2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                              Message for Today

                                                                                                              ICF

                                                                                                              Interstitial

                                                                                                              Pla

                                                                                                              sma

                                                                                                              5 Dex

                                                                                                              bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                              • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                              • Slide 2
                                                                                                              • Slide 3
                                                                                                              • Slide 4
                                                                                                              • Total Body Water
                                                                                                              • Body Fluid Compartments
                                                                                                              • Total body water (TBW)
                                                                                                              • Body compartment fluid
                                                                                                              • Example men with 70kg
                                                                                                              • Fluid compartments
                                                                                                              • Slide 11
                                                                                                              • Slide 12
                                                                                                              • Slide 13
                                                                                                              • Slide 14
                                                                                                              • Slide 15
                                                                                                              • Colloid osmotic pressure
                                                                                                              • Slide 17
                                                                                                              • Slide 18
                                                                                                              • Slide 19
                                                                                                              • Cell Membrane
                                                                                                              • Slide 21
                                                                                                              • Slide 22
                                                                                                              • Slide 23
                                                                                                              • Slide 24
                                                                                                              • Slide 25
                                                                                                              • Composition of Fluid Compartments
                                                                                                              • Composition of Body Fluids
                                                                                                              • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                              • Reasons for fluid therapy
                                                                                                              • ارزیابی حجم مایع داخل عروقی
                                                                                                              • محلولهای وریدی
                                                                                                              • Fluids
                                                                                                              • Slide 33
                                                                                                              • Slide 34
                                                                                                              • Slide 35
                                                                                                              • Crystalloids
                                                                                                              • Colloid Solutions
                                                                                                              • رینگر لاکتات
                                                                                                              • 09Nacl
                                                                                                              • Postoperative (maintenance)
                                                                                                              • Slide 41
                                                                                                              • Preexisting fluid deficits
                                                                                                              • Maintenance requirements
                                                                                                              • Surgical fluid losses
                                                                                                              • Third space loss
                                                                                                              • Crystalloid solution
                                                                                                              • Colloids
                                                                                                              • Complications
                                                                                                              • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                              • Colloid versus crystalloid solutions
                                                                                                              • Transfusion consideration
                                                                                                              • اختلال در حجم مایعات بدن
                                                                                                              • Fluid volume deficit (FVD)
                                                                                                              • DEHYDRATION
                                                                                                              • علل کاهش حجم خارج سلولی
                                                                                                              • Signs of Hypovolemia
                                                                                                              • Clinical Diagnosis of Hypovolemia
                                                                                                              • Signs of Hypervolemia
                                                                                                              • Management of Hypervolemia
                                                                                                              • Fluid Management
                                                                                                              • Electrolyte physiology
                                                                                                              • Sodium physiology
                                                                                                              • Osmotic Pressure
                                                                                                              • Concentration
                                                                                                              • Hypernatremia
                                                                                                              • - Hypernatremia
                                                                                                              • Slide 67
                                                                                                              • Slide 68
                                                                                                              • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                              • Treatment
                                                                                                              • Water deficit (L)= times TBW
                                                                                                              • The rate of fluid administration
                                                                                                              • Hyponatremia Nalt135mEqL
                                                                                                              • Slide 74
                                                                                                              • Sodium depletion
                                                                                                              • Sodium dilution
                                                                                                              • Sign and symptoms
                                                                                                              • Slide 78
                                                                                                              • Treatment
                                                                                                              • Slide 80
                                                                                                              • Slide 81
                                                                                                              • Dose
                                                                                                              • Potassium abnormalities
                                                                                                              • Hyperkalemia
                                                                                                              • Clinical manifestation of hyperkalemia
                                                                                                              • Slide 86
                                                                                                              • Slide 87
                                                                                                              • Hypokalemia
                                                                                                              • Potassium changes associated with alkalosis
                                                                                                              • Slide 90
                                                                                                              • Clinical Manifestation of Abnormalities in potassium
                                                                                                              • Slide 92
                                                                                                              • Calcium
                                                                                                              • هيپوكلسمي یونیزه Calt45 meql
                                                                                                              • علائم هیپوکلسمی
                                                                                                              • Slide 96
                                                                                                              • Slide 97
                                                                                                              • Slide 98
                                                                                                              • Slide 99
                                                                                                              • سایرعلائم
                                                                                                              • درمان
                                                                                                              • هيپركلسمي Cagt55meql
                                                                                                              • علائم
                                                                                                              • علائم قلبی
                                                                                                              • Slide 105
                                                                                                              • Magnesium Abnormalities
                                                                                                              • منیزیوم
                                                                                                              • Hypermagnesemia
                                                                                                              • Clinical manifestation hypermanesemia
                                                                                                              • Slide 110
                                                                                                              • Slide 111
                                                                                                              • Hypomagnesemia
                                                                                                              • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                              • Slide 114
                                                                                                              • Message for Today
                                                                                                              • Slide 116

                                                                                                                Clinical Diagnosis of Clinical Diagnosis of HypovolemiaHypovolemia

                                                                                                                bull Thorough history taking poor intake GI bleedinghellipetcbull BUN Creatinine gt 20 1 - BUNuarr hyperalimentation glucocorticoid therapy UGI bleedingbull Increased specific gravitybull Increased hematocritbull Electrolytes imbalancebull Acid-base disorder

                                                                                                                Signs of HypervolemiaSigns of Hypervolemia

                                                                                                                bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                                                                Especially when hypo-albuminemia

                                                                                                                Management of Management of HypervolemiaHypervolemia

                                                                                                                bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                                                                Fluid ManagementFluid Management

                                                                                                                bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                                                Electrolyte physiology

                                                                                                                Sodium physiology

                                                                                                                Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                                                Normal amount 135-145 meql

                                                                                                                Osmotic Pressure

                                                                                                                Calculated serum osmolality =

                                                                                                                2 sodium+ glucose18 + BUN 28

                                                                                                                Osmolality = 290 mosm

                                                                                                                Concentration

                                                                                                                1Serum sodium concentration2Serum osmolarity

                                                                                                                bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                                                drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                                                DW5)

                                                                                                                Hypernatremia

                                                                                                                Serum Nagt145mEqL

                                                                                                                - Hypernatremia

                                                                                                                Loss of Free Water

                                                                                                                Gain of sodium in excess of water

                                                                                                                Hypernatremia

                                                                                                                -Hypernatremia Hypo volemic

                                                                                                                Hyper volemic

                                                                                                                Normo volemic

                                                                                                                Hypernatremia

                                                                                                                Volume Status

                                                                                                                Normal

                                                                                                                Nonrenal water loss

                                                                                                                Skin

                                                                                                                Gastrointestinal

                                                                                                                Renal water loss

                                                                                                                Renal disease

                                                                                                                Diuretics

                                                                                                                Diabetes insipidus

                                                                                                                High

                                                                                                                Iatrogenic sodium administration

                                                                                                                Mineralocorticoid excess

                                                                                                                Aldosteronism

                                                                                                                Cushingrsquos disease

                                                                                                                Congenital adrenal

                                                                                                                hyperplasia

                                                                                                                Low

                                                                                                                Nonrenal water loss

                                                                                                                Skin

                                                                                                                Gastrointestinal losses

                                                                                                                Renal water losses

                                                                                                                Renal (tubular) Diuretics

                                                                                                                Osmotic diuretics

                                                                                                                Diabetes insipidus

                                                                                                                Adrenal failure

                                                                                                                Asymptomatic

                                                                                                                Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                                Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                                Body system hypernatremia

                                                                                                                Treatment

                                                                                                                Normal saline in hypovolemic patients

                                                                                                                Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                                saline or entral water)

                                                                                                                Water deficit (L)= times TBW

                                                                                                                The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                                Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                                Serum sodium-140

                                                                                                                140

                                                                                                                The rate of fluid administration

                                                                                                                1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                                2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                                Hyponatremia Nalt135mEqL

                                                                                                                Causes

                                                                                                                1 Sodium depletion

                                                                                                                2 Sodium dilution

                                                                                                                bull Incidence = 45

                                                                                                                bull After surgery=1

                                                                                                                bull Mortality = 2 times normal

                                                                                                                Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                                volume deficit

                                                                                                                Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                Sign and symptoms

                                                                                                                bull CNS symptom when Nalt123 meql

                                                                                                                bull Cardiac symptom when Nalt100 meql

                                                                                                                For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                Body System Hyponatremia

                                                                                                                central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                reflexes seizures coma increased intracranial pressure

                                                                                                                Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                intracranial pressure

                                                                                                                Tissue Lacrimation salivation

                                                                                                                Renal Oliguria

                                                                                                                Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                Treatment

                                                                                                                1=Depend on ECF

                                                                                                                2=CNS sign

                                                                                                                Treatment

                                                                                                                1 Asymptomatic increase the sodium level by no more than

                                                                                                                05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                meqL or neurologic symptoms are improved

                                                                                                                Rapid correction of hyponatremia

                                                                                                                Pontine myelinolysis

                                                                                                                Seizures weaknessparesis akinetic

                                                                                                                movements unresponsiveness

                                                                                                                Permanent brain damage

                                                                                                                Death

                                                                                                                Dose

                                                                                                                Na deficit meq =(140- Na meql) TBW

                                                                                                                باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                شود اصالح آهسته سپس

                                                                                                                Potassium abnormalities

                                                                                                                bull The average dietary intake of potassium 50-100meqd

                                                                                                                bull The average renal excretion of potassium 10-700 meqd

                                                                                                                - 2 of the total body potassium in ECF (45meqL)

                                                                                                                - Factors that influence serum potassium

                                                                                                                1 Surgical stress

                                                                                                                2 Injury

                                                                                                                3 Acidosis

                                                                                                                4 Tissue catabolism

                                                                                                                Hyperkalemia

                                                                                                                The normal range of serum potassium 35-5 meqL

                                                                                                                Etiology of Hyperkalemia

                                                                                                                Increased intake Potassium supplementation

                                                                                                                Blood transfusions

                                                                                                                Endogenous loaddestruction

                                                                                                                hemolysis rhabdomyolysis

                                                                                                                cruch injury gastrointestinal hemorrhage

                                                                                                                Increased release Acidosis

                                                                                                                Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                Renal insufficiencyfailure

                                                                                                                Clinical manifestation of hyperkalemia

                                                                                                                System hyperkalemia

                                                                                                                Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                Neuromuscular weakness paralysis respiratory failure

                                                                                                                Cardiovascular Arrhythmia arrest

                                                                                                                ECG changes Peaked T waves (early change)

                                                                                                                Flattened P wave

                                                                                                                Prolonged PR interval (first-degree block)

                                                                                                                Widened QRS complex

                                                                                                                Sine wave formation

                                                                                                                Ventricular fibrillation

                                                                                                                Treatment

                                                                                                                Treatment of symptomatic hyperkalemia

                                                                                                                Potassium removal Kayexalate

                                                                                                                Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                Dialysis

                                                                                                                Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                Bicarbonate 1 vial intravenous

                                                                                                                Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                HypokalemiaEtiology

                                                                                                                inadequate intake

                                                                                                                Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                total parenteral nutrition

                                                                                                                Excessive potassium excretion

                                                                                                                Hyperaldosteronism

                                                                                                                Medications

                                                                                                                Gastrointestinal losses

                                                                                                                Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                nasogastric output)

                                                                                                                Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                Potassium changes associated with alkalosis

                                                                                                                Potassium decrease by 03 meqL for every 01

                                                                                                                increase in PH above normal

                                                                                                                Magnesium Depletion

                                                                                                                (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                Renal potassium wastage

                                                                                                                Hypokalemia

                                                                                                                Magnesium Depletion

                                                                                                                (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                Renal potassium wastage

                                                                                                                Hypokalemia

                                                                                                                Clinical Manifestation of Abnormalities in potassium

                                                                                                                System hypokalemia

                                                                                                                Gastrointestinal Ileus constipation

                                                                                                                Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                paralysis

                                                                                                                Cardiovascular Arrest

                                                                                                                ECG changes U-waves

                                                                                                                T-wave flattening

                                                                                                                ST-segment changes

                                                                                                                Arrhythmias

                                                                                                                Treatment

                                                                                                                Potassium

                                                                                                                Serum potassium level lt40 mEqL

                                                                                                                Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                times 1 doses

                                                                                                                Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                asymptomatic replace as per above protocol

                                                                                                                Electrolyte Replacement Therapy Protocol

                                                                                                                bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                صاف 2 عضالت انقباض

                                                                                                                هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                انعقاد 4

                                                                                                                یونیزه Calt45 meql هيپوكلسمي

                                                                                                                عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                ( شود می پیوند شده

                                                                                                                هیپوکلسمی عالئم

                                                                                                                رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                سایرعالئم

                                                                                                                قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                درمان

                                                                                                                ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                Cagt55meql هيپركلسمي

                                                                                                                هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                عالئم

                                                                                                                bullGI

                                                                                                                bullCardiovascular bullRenal (polyuria)

                                                                                                                bullCNS

                                                                                                                قلبی عالئم

                                                                                                                bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                QRS شدن )Q-Tوكوتاه

                                                                                                                درمان

                                                                                                                ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                الزیکس2

                                                                                                                تونین 3 کلسی

                                                                                                                کورتون4

                                                                                                                دیالیز5

                                                                                                                Magnesium Abnormalities

                                                                                                                Normal dietary intake 20meq (240mg)

                                                                                                                Excretion in both the feces and urine

                                                                                                                Normal serum level 19-25 mgdL

                                                                                                                منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                Hypermagnesemia

                                                                                                                Etiology

                                                                                                                1 Impaired renal function

                                                                                                                2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                Clinical manifestation hypermanesemia

                                                                                                                System hypermanesemia

                                                                                                                Gastrointestinal Nauseavomiting

                                                                                                                Neuromuscular weakness lethargy Decreased

                                                                                                                reflexes

                                                                                                                Cardiovascular Hypotension arrest

                                                                                                                ECG changes Increased PR interval

                                                                                                                Widened QRS complex

                                                                                                                Elevated T waves

                                                                                                                Treatment

                                                                                                                1 Withhold exogenous sources of magnesium

                                                                                                                2 Correct volume deficit

                                                                                                                3 Correct acidosis if present

                                                                                                                4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                عالئم

                                                                                                                bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                meqL

                                                                                                                Hypomagnesemia

                                                                                                                Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                homeostasis

                                                                                                                Etiology

                                                                                                                1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                inadequate supplementation of magnesium)

                                                                                                                2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                3 GI losses (diarrhea)

                                                                                                                4 Malabsorption

                                                                                                                5 Acute pancreatitis

                                                                                                                6 Diabetic ketoacidosis

                                                                                                                7 Primary aldosteronism

                                                                                                                Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                2 Delirium and seizures in severe deficiency

                                                                                                                3 ECG changes Prolonged QT and PR interval

                                                                                                                ST-segment depression

                                                                                                                Flattening or inversion of P waves

                                                                                                                Torsades de pointes

                                                                                                                Arrhythmia

                                                                                                                Treatment

                                                                                                                1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                Message for Today

                                                                                                                ICF

                                                                                                                Interstitial

                                                                                                                Pla

                                                                                                                sma

                                                                                                                5 Dex

                                                                                                                bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                • Slide 2
                                                                                                                • Slide 3
                                                                                                                • Slide 4
                                                                                                                • Total Body Water
                                                                                                                • Body Fluid Compartments
                                                                                                                • Total body water (TBW)
                                                                                                                • Body compartment fluid
                                                                                                                • Example men with 70kg
                                                                                                                • Fluid compartments
                                                                                                                • Slide 11
                                                                                                                • Slide 12
                                                                                                                • Slide 13
                                                                                                                • Slide 14
                                                                                                                • Slide 15
                                                                                                                • Colloid osmotic pressure
                                                                                                                • Slide 17
                                                                                                                • Slide 18
                                                                                                                • Slide 19
                                                                                                                • Cell Membrane
                                                                                                                • Slide 21
                                                                                                                • Slide 22
                                                                                                                • Slide 23
                                                                                                                • Slide 24
                                                                                                                • Slide 25
                                                                                                                • Composition of Fluid Compartments
                                                                                                                • Composition of Body Fluids
                                                                                                                • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                • Reasons for fluid therapy
                                                                                                                • ارزیابی حجم مایع داخل عروقی
                                                                                                                • محلولهای وریدی
                                                                                                                • Fluids
                                                                                                                • Slide 33
                                                                                                                • Slide 34
                                                                                                                • Slide 35
                                                                                                                • Crystalloids
                                                                                                                • Colloid Solutions
                                                                                                                • رینگر لاکتات
                                                                                                                • 09Nacl
                                                                                                                • Postoperative (maintenance)
                                                                                                                • Slide 41
                                                                                                                • Preexisting fluid deficits
                                                                                                                • Maintenance requirements
                                                                                                                • Surgical fluid losses
                                                                                                                • Third space loss
                                                                                                                • Crystalloid solution
                                                                                                                • Colloids
                                                                                                                • Complications
                                                                                                                • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                • Colloid versus crystalloid solutions
                                                                                                                • Transfusion consideration
                                                                                                                • اختلال در حجم مایعات بدن
                                                                                                                • Fluid volume deficit (FVD)
                                                                                                                • DEHYDRATION
                                                                                                                • علل کاهش حجم خارج سلولی
                                                                                                                • Signs of Hypovolemia
                                                                                                                • Clinical Diagnosis of Hypovolemia
                                                                                                                • Signs of Hypervolemia
                                                                                                                • Management of Hypervolemia
                                                                                                                • Fluid Management
                                                                                                                • Electrolyte physiology
                                                                                                                • Sodium physiology
                                                                                                                • Osmotic Pressure
                                                                                                                • Concentration
                                                                                                                • Hypernatremia
                                                                                                                • - Hypernatremia
                                                                                                                • Slide 67
                                                                                                                • Slide 68
                                                                                                                • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                • Treatment
                                                                                                                • Water deficit (L)= times TBW
                                                                                                                • The rate of fluid administration
                                                                                                                • Hyponatremia Nalt135mEqL
                                                                                                                • Slide 74
                                                                                                                • Sodium depletion
                                                                                                                • Sodium dilution
                                                                                                                • Sign and symptoms
                                                                                                                • Slide 78
                                                                                                                • Treatment
                                                                                                                • Slide 80
                                                                                                                • Slide 81
                                                                                                                • Dose
                                                                                                                • Potassium abnormalities
                                                                                                                • Hyperkalemia
                                                                                                                • Clinical manifestation of hyperkalemia
                                                                                                                • Slide 86
                                                                                                                • Slide 87
                                                                                                                • Hypokalemia
                                                                                                                • Potassium changes associated with alkalosis
                                                                                                                • Slide 90
                                                                                                                • Clinical Manifestation of Abnormalities in potassium
                                                                                                                • Slide 92
                                                                                                                • Calcium
                                                                                                                • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                • علائم هیپوکلسمی
                                                                                                                • Slide 96
                                                                                                                • Slide 97
                                                                                                                • Slide 98
                                                                                                                • Slide 99
                                                                                                                • سایرعلائم
                                                                                                                • درمان
                                                                                                                • هيپركلسمي Cagt55meql
                                                                                                                • علائم
                                                                                                                • علائم قلبی
                                                                                                                • Slide 105
                                                                                                                • Magnesium Abnormalities
                                                                                                                • منیزیوم
                                                                                                                • Hypermagnesemia
                                                                                                                • Clinical manifestation hypermanesemia
                                                                                                                • Slide 110
                                                                                                                • Slide 111
                                                                                                                • Hypomagnesemia
                                                                                                                • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                • Slide 114
                                                                                                                • Message for Today
                                                                                                                • Slide 116

                                                                                                                  Signs of HypervolemiaSigns of Hypervolemia

                                                                                                                  bull Hypertensionbull Polyuriabull Peripheral edemabull Wet lungbull Jugular vein engorgement

                                                                                                                  Especially when hypo-albuminemia

                                                                                                                  Management of Management of HypervolemiaHypervolemia

                                                                                                                  bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                                                                  Fluid ManagementFluid Management

                                                                                                                  bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                                                  Electrolyte physiology

                                                                                                                  Sodium physiology

                                                                                                                  Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                                                  Normal amount 135-145 meql

                                                                                                                  Osmotic Pressure

                                                                                                                  Calculated serum osmolality =

                                                                                                                  2 sodium+ glucose18 + BUN 28

                                                                                                                  Osmolality = 290 mosm

                                                                                                                  Concentration

                                                                                                                  1Serum sodium concentration2Serum osmolarity

                                                                                                                  bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                                                  drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                                                  DW5)

                                                                                                                  Hypernatremia

                                                                                                                  Serum Nagt145mEqL

                                                                                                                  - Hypernatremia

                                                                                                                  Loss of Free Water

                                                                                                                  Gain of sodium in excess of water

                                                                                                                  Hypernatremia

                                                                                                                  -Hypernatremia Hypo volemic

                                                                                                                  Hyper volemic

                                                                                                                  Normo volemic

                                                                                                                  Hypernatremia

                                                                                                                  Volume Status

                                                                                                                  Normal

                                                                                                                  Nonrenal water loss

                                                                                                                  Skin

                                                                                                                  Gastrointestinal

                                                                                                                  Renal water loss

                                                                                                                  Renal disease

                                                                                                                  Diuretics

                                                                                                                  Diabetes insipidus

                                                                                                                  High

                                                                                                                  Iatrogenic sodium administration

                                                                                                                  Mineralocorticoid excess

                                                                                                                  Aldosteronism

                                                                                                                  Cushingrsquos disease

                                                                                                                  Congenital adrenal

                                                                                                                  hyperplasia

                                                                                                                  Low

                                                                                                                  Nonrenal water loss

                                                                                                                  Skin

                                                                                                                  Gastrointestinal losses

                                                                                                                  Renal water losses

                                                                                                                  Renal (tubular) Diuretics

                                                                                                                  Osmotic diuretics

                                                                                                                  Diabetes insipidus

                                                                                                                  Adrenal failure

                                                                                                                  Asymptomatic

                                                                                                                  Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                                  Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                  Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                                  Body system hypernatremia

                                                                                                                  Treatment

                                                                                                                  Normal saline in hypovolemic patients

                                                                                                                  Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                                  saline or entral water)

                                                                                                                  Water deficit (L)= times TBW

                                                                                                                  The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                                  Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                                  Serum sodium-140

                                                                                                                  140

                                                                                                                  The rate of fluid administration

                                                                                                                  1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                                  2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                                  Hyponatremia Nalt135mEqL

                                                                                                                  Causes

                                                                                                                  1 Sodium depletion

                                                                                                                  2 Sodium dilution

                                                                                                                  bull Incidence = 45

                                                                                                                  bull After surgery=1

                                                                                                                  bull Mortality = 2 times normal

                                                                                                                  Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                                  volume deficit

                                                                                                                  Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                  Sign and symptoms

                                                                                                                  bull CNS symptom when Nalt123 meql

                                                                                                                  bull Cardiac symptom when Nalt100 meql

                                                                                                                  For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                  Body System Hyponatremia

                                                                                                                  central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                  reflexes seizures coma increased intracranial pressure

                                                                                                                  Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                  Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                  Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                  intracranial pressure

                                                                                                                  Tissue Lacrimation salivation

                                                                                                                  Renal Oliguria

                                                                                                                  Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                  Treatment

                                                                                                                  1=Depend on ECF

                                                                                                                  2=CNS sign

                                                                                                                  Treatment

                                                                                                                  1 Asymptomatic increase the sodium level by no more than

                                                                                                                  05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                  2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                  more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                  meqL or neurologic symptoms are improved

                                                                                                                  Rapid correction of hyponatremia

                                                                                                                  Pontine myelinolysis

                                                                                                                  Seizures weaknessparesis akinetic

                                                                                                                  movements unresponsiveness

                                                                                                                  Permanent brain damage

                                                                                                                  Death

                                                                                                                  Dose

                                                                                                                  Na deficit meq =(140- Na meql) TBW

                                                                                                                  باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                  شود اصالح آهسته سپس

                                                                                                                  Potassium abnormalities

                                                                                                                  bull The average dietary intake of potassium 50-100meqd

                                                                                                                  bull The average renal excretion of potassium 10-700 meqd

                                                                                                                  - 2 of the total body potassium in ECF (45meqL)

                                                                                                                  - Factors that influence serum potassium

                                                                                                                  1 Surgical stress

                                                                                                                  2 Injury

                                                                                                                  3 Acidosis

                                                                                                                  4 Tissue catabolism

                                                                                                                  Hyperkalemia

                                                                                                                  The normal range of serum potassium 35-5 meqL

                                                                                                                  Etiology of Hyperkalemia

                                                                                                                  Increased intake Potassium supplementation

                                                                                                                  Blood transfusions

                                                                                                                  Endogenous loaddestruction

                                                                                                                  hemolysis rhabdomyolysis

                                                                                                                  cruch injury gastrointestinal hemorrhage

                                                                                                                  Increased release Acidosis

                                                                                                                  Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                  Renal insufficiencyfailure

                                                                                                                  Clinical manifestation of hyperkalemia

                                                                                                                  System hyperkalemia

                                                                                                                  Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                  Neuromuscular weakness paralysis respiratory failure

                                                                                                                  Cardiovascular Arrhythmia arrest

                                                                                                                  ECG changes Peaked T waves (early change)

                                                                                                                  Flattened P wave

                                                                                                                  Prolonged PR interval (first-degree block)

                                                                                                                  Widened QRS complex

                                                                                                                  Sine wave formation

                                                                                                                  Ventricular fibrillation

                                                                                                                  Treatment

                                                                                                                  Treatment of symptomatic hyperkalemia

                                                                                                                  Potassium removal Kayexalate

                                                                                                                  Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                  Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                  Dialysis

                                                                                                                  Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                  Bicarbonate 1 vial intravenous

                                                                                                                  Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                  HypokalemiaEtiology

                                                                                                                  inadequate intake

                                                                                                                  Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                  total parenteral nutrition

                                                                                                                  Excessive potassium excretion

                                                                                                                  Hyperaldosteronism

                                                                                                                  Medications

                                                                                                                  Gastrointestinal losses

                                                                                                                  Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                  Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                  nasogastric output)

                                                                                                                  Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                  Potassium changes associated with alkalosis

                                                                                                                  Potassium decrease by 03 meqL for every 01

                                                                                                                  increase in PH above normal

                                                                                                                  Magnesium Depletion

                                                                                                                  (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                  Renal potassium wastage

                                                                                                                  Hypokalemia

                                                                                                                  Magnesium Depletion

                                                                                                                  (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                  Renal potassium wastage

                                                                                                                  Hypokalemia

                                                                                                                  Clinical Manifestation of Abnormalities in potassium

                                                                                                                  System hypokalemia

                                                                                                                  Gastrointestinal Ileus constipation

                                                                                                                  Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                  paralysis

                                                                                                                  Cardiovascular Arrest

                                                                                                                  ECG changes U-waves

                                                                                                                  T-wave flattening

                                                                                                                  ST-segment changes

                                                                                                                  Arrhythmias

                                                                                                                  Treatment

                                                                                                                  Potassium

                                                                                                                  Serum potassium level lt40 mEqL

                                                                                                                  Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                  times 1 doses

                                                                                                                  Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                  Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                  Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                  asymptomatic replace as per above protocol

                                                                                                                  Electrolyte Replacement Therapy Protocol

                                                                                                                  bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                  bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                  Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                  ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                  عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                  صاف 2 عضالت انقباض

                                                                                                                  هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                  انعقاد 4

                                                                                                                  یونیزه Calt45 meql هيپوكلسمي

                                                                                                                  عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                  ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                  میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                  ( شود می پیوند شده

                                                                                                                  هیپوکلسمی عالئم

                                                                                                                  رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                  سایرعالئم

                                                                                                                  قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                  درمان

                                                                                                                  ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                  Cagt55meql هيپركلسمي

                                                                                                                  هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                  عالئم

                                                                                                                  bullGI

                                                                                                                  bullCardiovascular bullRenal (polyuria)

                                                                                                                  bullCNS

                                                                                                                  قلبی عالئم

                                                                                                                  bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                  QRS شدن )Q-Tوكوتاه

                                                                                                                  درمان

                                                                                                                  ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                  الزیکس2

                                                                                                                  تونین 3 کلسی

                                                                                                                  کورتون4

                                                                                                                  دیالیز5

                                                                                                                  Magnesium Abnormalities

                                                                                                                  Normal dietary intake 20meq (240mg)

                                                                                                                  Excretion in both the feces and urine

                                                                                                                  Normal serum level 19-25 mgdL

                                                                                                                  منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                  تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                  bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                  Hypermagnesemia

                                                                                                                  Etiology

                                                                                                                  1 Impaired renal function

                                                                                                                  2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                  Clinical manifestation hypermanesemia

                                                                                                                  System hypermanesemia

                                                                                                                  Gastrointestinal Nauseavomiting

                                                                                                                  Neuromuscular weakness lethargy Decreased

                                                                                                                  reflexes

                                                                                                                  Cardiovascular Hypotension arrest

                                                                                                                  ECG changes Increased PR interval

                                                                                                                  Widened QRS complex

                                                                                                                  Elevated T waves

                                                                                                                  Treatment

                                                                                                                  1 Withhold exogenous sources of magnesium

                                                                                                                  2 Correct volume deficit

                                                                                                                  3 Correct acidosis if present

                                                                                                                  4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                  5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                  عالئم

                                                                                                                  bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                  meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                  meqL

                                                                                                                  Hypomagnesemia

                                                                                                                  Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                  homeostasis

                                                                                                                  Etiology

                                                                                                                  1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                  inadequate supplementation of magnesium)

                                                                                                                  2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                  3 GI losses (diarrhea)

                                                                                                                  4 Malabsorption

                                                                                                                  5 Acute pancreatitis

                                                                                                                  6 Diabetic ketoacidosis

                                                                                                                  7 Primary aldosteronism

                                                                                                                  Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                  1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                  2 Delirium and seizures in severe deficiency

                                                                                                                  3 ECG changes Prolonged QT and PR interval

                                                                                                                  ST-segment depression

                                                                                                                  Flattening or inversion of P waves

                                                                                                                  Torsades de pointes

                                                                                                                  Arrhythmia

                                                                                                                  Treatment

                                                                                                                  1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                  2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                  Message for Today

                                                                                                                  ICF

                                                                                                                  Interstitial

                                                                                                                  Pla

                                                                                                                  sma

                                                                                                                  5 Dex

                                                                                                                  bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                  • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                  • Slide 2
                                                                                                                  • Slide 3
                                                                                                                  • Slide 4
                                                                                                                  • Total Body Water
                                                                                                                  • Body Fluid Compartments
                                                                                                                  • Total body water (TBW)
                                                                                                                  • Body compartment fluid
                                                                                                                  • Example men with 70kg
                                                                                                                  • Fluid compartments
                                                                                                                  • Slide 11
                                                                                                                  • Slide 12
                                                                                                                  • Slide 13
                                                                                                                  • Slide 14
                                                                                                                  • Slide 15
                                                                                                                  • Colloid osmotic pressure
                                                                                                                  • Slide 17
                                                                                                                  • Slide 18
                                                                                                                  • Slide 19
                                                                                                                  • Cell Membrane
                                                                                                                  • Slide 21
                                                                                                                  • Slide 22
                                                                                                                  • Slide 23
                                                                                                                  • Slide 24
                                                                                                                  • Slide 25
                                                                                                                  • Composition of Fluid Compartments
                                                                                                                  • Composition of Body Fluids
                                                                                                                  • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                  • Reasons for fluid therapy
                                                                                                                  • ارزیابی حجم مایع داخل عروقی
                                                                                                                  • محلولهای وریدی
                                                                                                                  • Fluids
                                                                                                                  • Slide 33
                                                                                                                  • Slide 34
                                                                                                                  • Slide 35
                                                                                                                  • Crystalloids
                                                                                                                  • Colloid Solutions
                                                                                                                  • رینگر لاکتات
                                                                                                                  • 09Nacl
                                                                                                                  • Postoperative (maintenance)
                                                                                                                  • Slide 41
                                                                                                                  • Preexisting fluid deficits
                                                                                                                  • Maintenance requirements
                                                                                                                  • Surgical fluid losses
                                                                                                                  • Third space loss
                                                                                                                  • Crystalloid solution
                                                                                                                  • Colloids
                                                                                                                  • Complications
                                                                                                                  • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                  • Colloid versus crystalloid solutions
                                                                                                                  • Transfusion consideration
                                                                                                                  • اختلال در حجم مایعات بدن
                                                                                                                  • Fluid volume deficit (FVD)
                                                                                                                  • DEHYDRATION
                                                                                                                  • علل کاهش حجم خارج سلولی
                                                                                                                  • Signs of Hypovolemia
                                                                                                                  • Clinical Diagnosis of Hypovolemia
                                                                                                                  • Signs of Hypervolemia
                                                                                                                  • Management of Hypervolemia
                                                                                                                  • Fluid Management
                                                                                                                  • Electrolyte physiology
                                                                                                                  • Sodium physiology
                                                                                                                  • Osmotic Pressure
                                                                                                                  • Concentration
                                                                                                                  • Hypernatremia
                                                                                                                  • - Hypernatremia
                                                                                                                  • Slide 67
                                                                                                                  • Slide 68
                                                                                                                  • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                  • Treatment
                                                                                                                  • Water deficit (L)= times TBW
                                                                                                                  • The rate of fluid administration
                                                                                                                  • Hyponatremia Nalt135mEqL
                                                                                                                  • Slide 74
                                                                                                                  • Sodium depletion
                                                                                                                  • Sodium dilution
                                                                                                                  • Sign and symptoms
                                                                                                                  • Slide 78
                                                                                                                  • Treatment
                                                                                                                  • Slide 80
                                                                                                                  • Slide 81
                                                                                                                  • Dose
                                                                                                                  • Potassium abnormalities
                                                                                                                  • Hyperkalemia
                                                                                                                  • Clinical manifestation of hyperkalemia
                                                                                                                  • Slide 86
                                                                                                                  • Slide 87
                                                                                                                  • Hypokalemia
                                                                                                                  • Potassium changes associated with alkalosis
                                                                                                                  • Slide 90
                                                                                                                  • Clinical Manifestation of Abnormalities in potassium
                                                                                                                  • Slide 92
                                                                                                                  • Calcium
                                                                                                                  • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                  • علائم هیپوکلسمی
                                                                                                                  • Slide 96
                                                                                                                  • Slide 97
                                                                                                                  • Slide 98
                                                                                                                  • Slide 99
                                                                                                                  • سایرعلائم
                                                                                                                  • درمان
                                                                                                                  • هيپركلسمي Cagt55meql
                                                                                                                  • علائم
                                                                                                                  • علائم قلبی
                                                                                                                  • Slide 105
                                                                                                                  • Magnesium Abnormalities
                                                                                                                  • منیزیوم
                                                                                                                  • Hypermagnesemia
                                                                                                                  • Clinical manifestation hypermanesemia
                                                                                                                  • Slide 110
                                                                                                                  • Slide 111
                                                                                                                  • Hypomagnesemia
                                                                                                                  • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                  • Slide 114
                                                                                                                  • Message for Today
                                                                                                                  • Slide 116

                                                                                                                    Management of Management of HypervolemiaHypervolemia

                                                                                                                    bull Prevention is the best waybull Guide fluid therapy with CVP level or pulmonary wedge pressurebull Diureticsbull Increase oncotic pressure FFP or albumin infusion (may followed by diuretics)bull Dialysis

                                                                                                                    Fluid ManagementFluid Management

                                                                                                                    bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                                                    Electrolyte physiology

                                                                                                                    Sodium physiology

                                                                                                                    Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                                                    Normal amount 135-145 meql

                                                                                                                    Osmotic Pressure

                                                                                                                    Calculated serum osmolality =

                                                                                                                    2 sodium+ glucose18 + BUN 28

                                                                                                                    Osmolality = 290 mosm

                                                                                                                    Concentration

                                                                                                                    1Serum sodium concentration2Serum osmolarity

                                                                                                                    bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                                                    drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                                                    DW5)

                                                                                                                    Hypernatremia

                                                                                                                    Serum Nagt145mEqL

                                                                                                                    - Hypernatremia

                                                                                                                    Loss of Free Water

                                                                                                                    Gain of sodium in excess of water

                                                                                                                    Hypernatremia

                                                                                                                    -Hypernatremia Hypo volemic

                                                                                                                    Hyper volemic

                                                                                                                    Normo volemic

                                                                                                                    Hypernatremia

                                                                                                                    Volume Status

                                                                                                                    Normal

                                                                                                                    Nonrenal water loss

                                                                                                                    Skin

                                                                                                                    Gastrointestinal

                                                                                                                    Renal water loss

                                                                                                                    Renal disease

                                                                                                                    Diuretics

                                                                                                                    Diabetes insipidus

                                                                                                                    High

                                                                                                                    Iatrogenic sodium administration

                                                                                                                    Mineralocorticoid excess

                                                                                                                    Aldosteronism

                                                                                                                    Cushingrsquos disease

                                                                                                                    Congenital adrenal

                                                                                                                    hyperplasia

                                                                                                                    Low

                                                                                                                    Nonrenal water loss

                                                                                                                    Skin

                                                                                                                    Gastrointestinal losses

                                                                                                                    Renal water losses

                                                                                                                    Renal (tubular) Diuretics

                                                                                                                    Osmotic diuretics

                                                                                                                    Diabetes insipidus

                                                                                                                    Adrenal failure

                                                                                                                    Asymptomatic

                                                                                                                    Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                                    Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                    Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                                    Body system hypernatremia

                                                                                                                    Treatment

                                                                                                                    Normal saline in hypovolemic patients

                                                                                                                    Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                                    saline or entral water)

                                                                                                                    Water deficit (L)= times TBW

                                                                                                                    The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                                    Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                                    Serum sodium-140

                                                                                                                    140

                                                                                                                    The rate of fluid administration

                                                                                                                    1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                                    2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                                    Hyponatremia Nalt135mEqL

                                                                                                                    Causes

                                                                                                                    1 Sodium depletion

                                                                                                                    2 Sodium dilution

                                                                                                                    bull Incidence = 45

                                                                                                                    bull After surgery=1

                                                                                                                    bull Mortality = 2 times normal

                                                                                                                    Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                                    volume deficit

                                                                                                                    Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                    Sign and symptoms

                                                                                                                    bull CNS symptom when Nalt123 meql

                                                                                                                    bull Cardiac symptom when Nalt100 meql

                                                                                                                    For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                    Body System Hyponatremia

                                                                                                                    central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                    reflexes seizures coma increased intracranial pressure

                                                                                                                    Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                    Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                    Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                    intracranial pressure

                                                                                                                    Tissue Lacrimation salivation

                                                                                                                    Renal Oliguria

                                                                                                                    Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                    Treatment

                                                                                                                    1=Depend on ECF

                                                                                                                    2=CNS sign

                                                                                                                    Treatment

                                                                                                                    1 Asymptomatic increase the sodium level by no more than

                                                                                                                    05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                    2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                    more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                    meqL or neurologic symptoms are improved

                                                                                                                    Rapid correction of hyponatremia

                                                                                                                    Pontine myelinolysis

                                                                                                                    Seizures weaknessparesis akinetic

                                                                                                                    movements unresponsiveness

                                                                                                                    Permanent brain damage

                                                                                                                    Death

                                                                                                                    Dose

                                                                                                                    Na deficit meq =(140- Na meql) TBW

                                                                                                                    باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                    شود اصالح آهسته سپس

                                                                                                                    Potassium abnormalities

                                                                                                                    bull The average dietary intake of potassium 50-100meqd

                                                                                                                    bull The average renal excretion of potassium 10-700 meqd

                                                                                                                    - 2 of the total body potassium in ECF (45meqL)

                                                                                                                    - Factors that influence serum potassium

                                                                                                                    1 Surgical stress

                                                                                                                    2 Injury

                                                                                                                    3 Acidosis

                                                                                                                    4 Tissue catabolism

                                                                                                                    Hyperkalemia

                                                                                                                    The normal range of serum potassium 35-5 meqL

                                                                                                                    Etiology of Hyperkalemia

                                                                                                                    Increased intake Potassium supplementation

                                                                                                                    Blood transfusions

                                                                                                                    Endogenous loaddestruction

                                                                                                                    hemolysis rhabdomyolysis

                                                                                                                    cruch injury gastrointestinal hemorrhage

                                                                                                                    Increased release Acidosis

                                                                                                                    Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                    Renal insufficiencyfailure

                                                                                                                    Clinical manifestation of hyperkalemia

                                                                                                                    System hyperkalemia

                                                                                                                    Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                    Neuromuscular weakness paralysis respiratory failure

                                                                                                                    Cardiovascular Arrhythmia arrest

                                                                                                                    ECG changes Peaked T waves (early change)

                                                                                                                    Flattened P wave

                                                                                                                    Prolonged PR interval (first-degree block)

                                                                                                                    Widened QRS complex

                                                                                                                    Sine wave formation

                                                                                                                    Ventricular fibrillation

                                                                                                                    Treatment

                                                                                                                    Treatment of symptomatic hyperkalemia

                                                                                                                    Potassium removal Kayexalate

                                                                                                                    Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                    Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                    Dialysis

                                                                                                                    Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                    Bicarbonate 1 vial intravenous

                                                                                                                    Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                    HypokalemiaEtiology

                                                                                                                    inadequate intake

                                                                                                                    Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                    total parenteral nutrition

                                                                                                                    Excessive potassium excretion

                                                                                                                    Hyperaldosteronism

                                                                                                                    Medications

                                                                                                                    Gastrointestinal losses

                                                                                                                    Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                    Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                    nasogastric output)

                                                                                                                    Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                    Potassium changes associated with alkalosis

                                                                                                                    Potassium decrease by 03 meqL for every 01

                                                                                                                    increase in PH above normal

                                                                                                                    Magnesium Depletion

                                                                                                                    (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                    Renal potassium wastage

                                                                                                                    Hypokalemia

                                                                                                                    Magnesium Depletion

                                                                                                                    (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                    Renal potassium wastage

                                                                                                                    Hypokalemia

                                                                                                                    Clinical Manifestation of Abnormalities in potassium

                                                                                                                    System hypokalemia

                                                                                                                    Gastrointestinal Ileus constipation

                                                                                                                    Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                    paralysis

                                                                                                                    Cardiovascular Arrest

                                                                                                                    ECG changes U-waves

                                                                                                                    T-wave flattening

                                                                                                                    ST-segment changes

                                                                                                                    Arrhythmias

                                                                                                                    Treatment

                                                                                                                    Potassium

                                                                                                                    Serum potassium level lt40 mEqL

                                                                                                                    Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                    times 1 doses

                                                                                                                    Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                    Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                    Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                    asymptomatic replace as per above protocol

                                                                                                                    Electrolyte Replacement Therapy Protocol

                                                                                                                    bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                    bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                    Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                    ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                    عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                    صاف 2 عضالت انقباض

                                                                                                                    هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                    انعقاد 4

                                                                                                                    یونیزه Calt45 meql هيپوكلسمي

                                                                                                                    عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                    ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                    میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                    ( شود می پیوند شده

                                                                                                                    هیپوکلسمی عالئم

                                                                                                                    رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                    سایرعالئم

                                                                                                                    قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                    درمان

                                                                                                                    ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                    Cagt55meql هيپركلسمي

                                                                                                                    هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                    عالئم

                                                                                                                    bullGI

                                                                                                                    bullCardiovascular bullRenal (polyuria)

                                                                                                                    bullCNS

                                                                                                                    قلبی عالئم

                                                                                                                    bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                    QRS شدن )Q-Tوكوتاه

                                                                                                                    درمان

                                                                                                                    ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                    الزیکس2

                                                                                                                    تونین 3 کلسی

                                                                                                                    کورتون4

                                                                                                                    دیالیز5

                                                                                                                    Magnesium Abnormalities

                                                                                                                    Normal dietary intake 20meq (240mg)

                                                                                                                    Excretion in both the feces and urine

                                                                                                                    Normal serum level 19-25 mgdL

                                                                                                                    منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                    تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                    bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                    Hypermagnesemia

                                                                                                                    Etiology

                                                                                                                    1 Impaired renal function

                                                                                                                    2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                    Clinical manifestation hypermanesemia

                                                                                                                    System hypermanesemia

                                                                                                                    Gastrointestinal Nauseavomiting

                                                                                                                    Neuromuscular weakness lethargy Decreased

                                                                                                                    reflexes

                                                                                                                    Cardiovascular Hypotension arrest

                                                                                                                    ECG changes Increased PR interval

                                                                                                                    Widened QRS complex

                                                                                                                    Elevated T waves

                                                                                                                    Treatment

                                                                                                                    1 Withhold exogenous sources of magnesium

                                                                                                                    2 Correct volume deficit

                                                                                                                    3 Correct acidosis if present

                                                                                                                    4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                    5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                    عالئم

                                                                                                                    bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                    meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                    meqL

                                                                                                                    Hypomagnesemia

                                                                                                                    Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                    homeostasis

                                                                                                                    Etiology

                                                                                                                    1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                    inadequate supplementation of magnesium)

                                                                                                                    2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                    3 GI losses (diarrhea)

                                                                                                                    4 Malabsorption

                                                                                                                    5 Acute pancreatitis

                                                                                                                    6 Diabetic ketoacidosis

                                                                                                                    7 Primary aldosteronism

                                                                                                                    Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                    1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                    2 Delirium and seizures in severe deficiency

                                                                                                                    3 ECG changes Prolonged QT and PR interval

                                                                                                                    ST-segment depression

                                                                                                                    Flattening or inversion of P waves

                                                                                                                    Torsades de pointes

                                                                                                                    Arrhythmia

                                                                                                                    Treatment

                                                                                                                    1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                    2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                    Message for Today

                                                                                                                    ICF

                                                                                                                    Interstitial

                                                                                                                    Pla

                                                                                                                    sma

                                                                                                                    5 Dex

                                                                                                                    bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                    • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                    • Slide 2
                                                                                                                    • Slide 3
                                                                                                                    • Slide 4
                                                                                                                    • Total Body Water
                                                                                                                    • Body Fluid Compartments
                                                                                                                    • Total body water (TBW)
                                                                                                                    • Body compartment fluid
                                                                                                                    • Example men with 70kg
                                                                                                                    • Fluid compartments
                                                                                                                    • Slide 11
                                                                                                                    • Slide 12
                                                                                                                    • Slide 13
                                                                                                                    • Slide 14
                                                                                                                    • Slide 15
                                                                                                                    • Colloid osmotic pressure
                                                                                                                    • Slide 17
                                                                                                                    • Slide 18
                                                                                                                    • Slide 19
                                                                                                                    • Cell Membrane
                                                                                                                    • Slide 21
                                                                                                                    • Slide 22
                                                                                                                    • Slide 23
                                                                                                                    • Slide 24
                                                                                                                    • Slide 25
                                                                                                                    • Composition of Fluid Compartments
                                                                                                                    • Composition of Body Fluids
                                                                                                                    • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                    • Reasons for fluid therapy
                                                                                                                    • ارزیابی حجم مایع داخل عروقی
                                                                                                                    • محلولهای وریدی
                                                                                                                    • Fluids
                                                                                                                    • Slide 33
                                                                                                                    • Slide 34
                                                                                                                    • Slide 35
                                                                                                                    • Crystalloids
                                                                                                                    • Colloid Solutions
                                                                                                                    • رینگر لاکتات
                                                                                                                    • 09Nacl
                                                                                                                    • Postoperative (maintenance)
                                                                                                                    • Slide 41
                                                                                                                    • Preexisting fluid deficits
                                                                                                                    • Maintenance requirements
                                                                                                                    • Surgical fluid losses
                                                                                                                    • Third space loss
                                                                                                                    • Crystalloid solution
                                                                                                                    • Colloids
                                                                                                                    • Complications
                                                                                                                    • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                    • Colloid versus crystalloid solutions
                                                                                                                    • Transfusion consideration
                                                                                                                    • اختلال در حجم مایعات بدن
                                                                                                                    • Fluid volume deficit (FVD)
                                                                                                                    • DEHYDRATION
                                                                                                                    • علل کاهش حجم خارج سلولی
                                                                                                                    • Signs of Hypovolemia
                                                                                                                    • Clinical Diagnosis of Hypovolemia
                                                                                                                    • Signs of Hypervolemia
                                                                                                                    • Management of Hypervolemia
                                                                                                                    • Fluid Management
                                                                                                                    • Electrolyte physiology
                                                                                                                    • Sodium physiology
                                                                                                                    • Osmotic Pressure
                                                                                                                    • Concentration
                                                                                                                    • Hypernatremia
                                                                                                                    • - Hypernatremia
                                                                                                                    • Slide 67
                                                                                                                    • Slide 68
                                                                                                                    • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                    • Treatment
                                                                                                                    • Water deficit (L)= times TBW
                                                                                                                    • The rate of fluid administration
                                                                                                                    • Hyponatremia Nalt135mEqL
                                                                                                                    • Slide 74
                                                                                                                    • Sodium depletion
                                                                                                                    • Sodium dilution
                                                                                                                    • Sign and symptoms
                                                                                                                    • Slide 78
                                                                                                                    • Treatment
                                                                                                                    • Slide 80
                                                                                                                    • Slide 81
                                                                                                                    • Dose
                                                                                                                    • Potassium abnormalities
                                                                                                                    • Hyperkalemia
                                                                                                                    • Clinical manifestation of hyperkalemia
                                                                                                                    • Slide 86
                                                                                                                    • Slide 87
                                                                                                                    • Hypokalemia
                                                                                                                    • Potassium changes associated with alkalosis
                                                                                                                    • Slide 90
                                                                                                                    • Clinical Manifestation of Abnormalities in potassium
                                                                                                                    • Slide 92
                                                                                                                    • Calcium
                                                                                                                    • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                    • علائم هیپوکلسمی
                                                                                                                    • Slide 96
                                                                                                                    • Slide 97
                                                                                                                    • Slide 98
                                                                                                                    • Slide 99
                                                                                                                    • سایرعلائم
                                                                                                                    • درمان
                                                                                                                    • هيپركلسمي Cagt55meql
                                                                                                                    • علائم
                                                                                                                    • علائم قلبی
                                                                                                                    • Slide 105
                                                                                                                    • Magnesium Abnormalities
                                                                                                                    • منیزیوم
                                                                                                                    • Hypermagnesemia
                                                                                                                    • Clinical manifestation hypermanesemia
                                                                                                                    • Slide 110
                                                                                                                    • Slide 111
                                                                                                                    • Hypomagnesemia
                                                                                                                    • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                    • Slide 114
                                                                                                                    • Message for Today
                                                                                                                    • Slide 116

                                                                                                                      Fluid ManagementFluid Management

                                                                                                                      bull GoalGoal - to maintain urine output of 05~10mgkghbull RuleRule bull Electrolytes requireElectrolytes require - Na+ 1-2mmolkgday - K+ 05~10mmolkgdaybull Avoid fluid overload especially in malnutrition heart failure and renal insufficiency patient

                                                                                                                      Electrolyte physiology

                                                                                                                      Sodium physiology

                                                                                                                      Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                                                      Normal amount 135-145 meql

                                                                                                                      Osmotic Pressure

                                                                                                                      Calculated serum osmolality =

                                                                                                                      2 sodium+ glucose18 + BUN 28

                                                                                                                      Osmolality = 290 mosm

                                                                                                                      Concentration

                                                                                                                      1Serum sodium concentration2Serum osmolarity

                                                                                                                      bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                                                      drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                                                      DW5)

                                                                                                                      Hypernatremia

                                                                                                                      Serum Nagt145mEqL

                                                                                                                      - Hypernatremia

                                                                                                                      Loss of Free Water

                                                                                                                      Gain of sodium in excess of water

                                                                                                                      Hypernatremia

                                                                                                                      -Hypernatremia Hypo volemic

                                                                                                                      Hyper volemic

                                                                                                                      Normo volemic

                                                                                                                      Hypernatremia

                                                                                                                      Volume Status

                                                                                                                      Normal

                                                                                                                      Nonrenal water loss

                                                                                                                      Skin

                                                                                                                      Gastrointestinal

                                                                                                                      Renal water loss

                                                                                                                      Renal disease

                                                                                                                      Diuretics

                                                                                                                      Diabetes insipidus

                                                                                                                      High

                                                                                                                      Iatrogenic sodium administration

                                                                                                                      Mineralocorticoid excess

                                                                                                                      Aldosteronism

                                                                                                                      Cushingrsquos disease

                                                                                                                      Congenital adrenal

                                                                                                                      hyperplasia

                                                                                                                      Low

                                                                                                                      Nonrenal water loss

                                                                                                                      Skin

                                                                                                                      Gastrointestinal losses

                                                                                                                      Renal water losses

                                                                                                                      Renal (tubular) Diuretics

                                                                                                                      Osmotic diuretics

                                                                                                                      Diabetes insipidus

                                                                                                                      Adrenal failure

                                                                                                                      Asymptomatic

                                                                                                                      Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                                      Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                      Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                                      Body system hypernatremia

                                                                                                                      Treatment

                                                                                                                      Normal saline in hypovolemic patients

                                                                                                                      Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                                      saline or entral water)

                                                                                                                      Water deficit (L)= times TBW

                                                                                                                      The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                                      Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                                      Serum sodium-140

                                                                                                                      140

                                                                                                                      The rate of fluid administration

                                                                                                                      1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                                      2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                                      Hyponatremia Nalt135mEqL

                                                                                                                      Causes

                                                                                                                      1 Sodium depletion

                                                                                                                      2 Sodium dilution

                                                                                                                      bull Incidence = 45

                                                                                                                      bull After surgery=1

                                                                                                                      bull Mortality = 2 times normal

                                                                                                                      Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                                      volume deficit

                                                                                                                      Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                      Sign and symptoms

                                                                                                                      bull CNS symptom when Nalt123 meql

                                                                                                                      bull Cardiac symptom when Nalt100 meql

                                                                                                                      For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                      Body System Hyponatremia

                                                                                                                      central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                      reflexes seizures coma increased intracranial pressure

                                                                                                                      Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                      Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                      Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                      intracranial pressure

                                                                                                                      Tissue Lacrimation salivation

                                                                                                                      Renal Oliguria

                                                                                                                      Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                      Treatment

                                                                                                                      1=Depend on ECF

                                                                                                                      2=CNS sign

                                                                                                                      Treatment

                                                                                                                      1 Asymptomatic increase the sodium level by no more than

                                                                                                                      05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                      2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                      more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                      meqL or neurologic symptoms are improved

                                                                                                                      Rapid correction of hyponatremia

                                                                                                                      Pontine myelinolysis

                                                                                                                      Seizures weaknessparesis akinetic

                                                                                                                      movements unresponsiveness

                                                                                                                      Permanent brain damage

                                                                                                                      Death

                                                                                                                      Dose

                                                                                                                      Na deficit meq =(140- Na meql) TBW

                                                                                                                      باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                      شود اصالح آهسته سپس

                                                                                                                      Potassium abnormalities

                                                                                                                      bull The average dietary intake of potassium 50-100meqd

                                                                                                                      bull The average renal excretion of potassium 10-700 meqd

                                                                                                                      - 2 of the total body potassium in ECF (45meqL)

                                                                                                                      - Factors that influence serum potassium

                                                                                                                      1 Surgical stress

                                                                                                                      2 Injury

                                                                                                                      3 Acidosis

                                                                                                                      4 Tissue catabolism

                                                                                                                      Hyperkalemia

                                                                                                                      The normal range of serum potassium 35-5 meqL

                                                                                                                      Etiology of Hyperkalemia

                                                                                                                      Increased intake Potassium supplementation

                                                                                                                      Blood transfusions

                                                                                                                      Endogenous loaddestruction

                                                                                                                      hemolysis rhabdomyolysis

                                                                                                                      cruch injury gastrointestinal hemorrhage

                                                                                                                      Increased release Acidosis

                                                                                                                      Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                      Renal insufficiencyfailure

                                                                                                                      Clinical manifestation of hyperkalemia

                                                                                                                      System hyperkalemia

                                                                                                                      Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                      Neuromuscular weakness paralysis respiratory failure

                                                                                                                      Cardiovascular Arrhythmia arrest

                                                                                                                      ECG changes Peaked T waves (early change)

                                                                                                                      Flattened P wave

                                                                                                                      Prolonged PR interval (first-degree block)

                                                                                                                      Widened QRS complex

                                                                                                                      Sine wave formation

                                                                                                                      Ventricular fibrillation

                                                                                                                      Treatment

                                                                                                                      Treatment of symptomatic hyperkalemia

                                                                                                                      Potassium removal Kayexalate

                                                                                                                      Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                      Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                      Dialysis

                                                                                                                      Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                      Bicarbonate 1 vial intravenous

                                                                                                                      Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                      HypokalemiaEtiology

                                                                                                                      inadequate intake

                                                                                                                      Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                      total parenteral nutrition

                                                                                                                      Excessive potassium excretion

                                                                                                                      Hyperaldosteronism

                                                                                                                      Medications

                                                                                                                      Gastrointestinal losses

                                                                                                                      Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                      Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                      nasogastric output)

                                                                                                                      Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                      Potassium changes associated with alkalosis

                                                                                                                      Potassium decrease by 03 meqL for every 01

                                                                                                                      increase in PH above normal

                                                                                                                      Magnesium Depletion

                                                                                                                      (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                      Renal potassium wastage

                                                                                                                      Hypokalemia

                                                                                                                      Magnesium Depletion

                                                                                                                      (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                      Renal potassium wastage

                                                                                                                      Hypokalemia

                                                                                                                      Clinical Manifestation of Abnormalities in potassium

                                                                                                                      System hypokalemia

                                                                                                                      Gastrointestinal Ileus constipation

                                                                                                                      Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                      paralysis

                                                                                                                      Cardiovascular Arrest

                                                                                                                      ECG changes U-waves

                                                                                                                      T-wave flattening

                                                                                                                      ST-segment changes

                                                                                                                      Arrhythmias

                                                                                                                      Treatment

                                                                                                                      Potassium

                                                                                                                      Serum potassium level lt40 mEqL

                                                                                                                      Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                      times 1 doses

                                                                                                                      Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                      Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                      Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                      asymptomatic replace as per above protocol

                                                                                                                      Electrolyte Replacement Therapy Protocol

                                                                                                                      bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                      bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                      Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                      ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                      عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                      صاف 2 عضالت انقباض

                                                                                                                      هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                      انعقاد 4

                                                                                                                      یونیزه Calt45 meql هيپوكلسمي

                                                                                                                      عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                      ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                      میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                      ( شود می پیوند شده

                                                                                                                      هیپوکلسمی عالئم

                                                                                                                      رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                      سایرعالئم

                                                                                                                      قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                      درمان

                                                                                                                      ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                      Cagt55meql هيپركلسمي

                                                                                                                      هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                      عالئم

                                                                                                                      bullGI

                                                                                                                      bullCardiovascular bullRenal (polyuria)

                                                                                                                      bullCNS

                                                                                                                      قلبی عالئم

                                                                                                                      bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                      QRS شدن )Q-Tوكوتاه

                                                                                                                      درمان

                                                                                                                      ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                      الزیکس2

                                                                                                                      تونین 3 کلسی

                                                                                                                      کورتون4

                                                                                                                      دیالیز5

                                                                                                                      Magnesium Abnormalities

                                                                                                                      Normal dietary intake 20meq (240mg)

                                                                                                                      Excretion in both the feces and urine

                                                                                                                      Normal serum level 19-25 mgdL

                                                                                                                      منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                      تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                      bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                      Hypermagnesemia

                                                                                                                      Etiology

                                                                                                                      1 Impaired renal function

                                                                                                                      2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                      Clinical manifestation hypermanesemia

                                                                                                                      System hypermanesemia

                                                                                                                      Gastrointestinal Nauseavomiting

                                                                                                                      Neuromuscular weakness lethargy Decreased

                                                                                                                      reflexes

                                                                                                                      Cardiovascular Hypotension arrest

                                                                                                                      ECG changes Increased PR interval

                                                                                                                      Widened QRS complex

                                                                                                                      Elevated T waves

                                                                                                                      Treatment

                                                                                                                      1 Withhold exogenous sources of magnesium

                                                                                                                      2 Correct volume deficit

                                                                                                                      3 Correct acidosis if present

                                                                                                                      4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                      5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                      عالئم

                                                                                                                      bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                      meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                      meqL

                                                                                                                      Hypomagnesemia

                                                                                                                      Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                      homeostasis

                                                                                                                      Etiology

                                                                                                                      1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                      inadequate supplementation of magnesium)

                                                                                                                      2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                      3 GI losses (diarrhea)

                                                                                                                      4 Malabsorption

                                                                                                                      5 Acute pancreatitis

                                                                                                                      6 Diabetic ketoacidosis

                                                                                                                      7 Primary aldosteronism

                                                                                                                      Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                      1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                      2 Delirium and seizures in severe deficiency

                                                                                                                      3 ECG changes Prolonged QT and PR interval

                                                                                                                      ST-segment depression

                                                                                                                      Flattening or inversion of P waves

                                                                                                                      Torsades de pointes

                                                                                                                      Arrhythmia

                                                                                                                      Treatment

                                                                                                                      1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                      2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                      Message for Today

                                                                                                                      ICF

                                                                                                                      Interstitial

                                                                                                                      Pla

                                                                                                                      sma

                                                                                                                      5 Dex

                                                                                                                      bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                      • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                      • Slide 2
                                                                                                                      • Slide 3
                                                                                                                      • Slide 4
                                                                                                                      • Total Body Water
                                                                                                                      • Body Fluid Compartments
                                                                                                                      • Total body water (TBW)
                                                                                                                      • Body compartment fluid
                                                                                                                      • Example men with 70kg
                                                                                                                      • Fluid compartments
                                                                                                                      • Slide 11
                                                                                                                      • Slide 12
                                                                                                                      • Slide 13
                                                                                                                      • Slide 14
                                                                                                                      • Slide 15
                                                                                                                      • Colloid osmotic pressure
                                                                                                                      • Slide 17
                                                                                                                      • Slide 18
                                                                                                                      • Slide 19
                                                                                                                      • Cell Membrane
                                                                                                                      • Slide 21
                                                                                                                      • Slide 22
                                                                                                                      • Slide 23
                                                                                                                      • Slide 24
                                                                                                                      • Slide 25
                                                                                                                      • Composition of Fluid Compartments
                                                                                                                      • Composition of Body Fluids
                                                                                                                      • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                      • Reasons for fluid therapy
                                                                                                                      • ارزیابی حجم مایع داخل عروقی
                                                                                                                      • محلولهای وریدی
                                                                                                                      • Fluids
                                                                                                                      • Slide 33
                                                                                                                      • Slide 34
                                                                                                                      • Slide 35
                                                                                                                      • Crystalloids
                                                                                                                      • Colloid Solutions
                                                                                                                      • رینگر لاکتات
                                                                                                                      • 09Nacl
                                                                                                                      • Postoperative (maintenance)
                                                                                                                      • Slide 41
                                                                                                                      • Preexisting fluid deficits
                                                                                                                      • Maintenance requirements
                                                                                                                      • Surgical fluid losses
                                                                                                                      • Third space loss
                                                                                                                      • Crystalloid solution
                                                                                                                      • Colloids
                                                                                                                      • Complications
                                                                                                                      • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                      • Colloid versus crystalloid solutions
                                                                                                                      • Transfusion consideration
                                                                                                                      • اختلال در حجم مایعات بدن
                                                                                                                      • Fluid volume deficit (FVD)
                                                                                                                      • DEHYDRATION
                                                                                                                      • علل کاهش حجم خارج سلولی
                                                                                                                      • Signs of Hypovolemia
                                                                                                                      • Clinical Diagnosis of Hypovolemia
                                                                                                                      • Signs of Hypervolemia
                                                                                                                      • Management of Hypervolemia
                                                                                                                      • Fluid Management
                                                                                                                      • Electrolyte physiology
                                                                                                                      • Sodium physiology
                                                                                                                      • Osmotic Pressure
                                                                                                                      • Concentration
                                                                                                                      • Hypernatremia
                                                                                                                      • - Hypernatremia
                                                                                                                      • Slide 67
                                                                                                                      • Slide 68
                                                                                                                      • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                      • Treatment
                                                                                                                      • Water deficit (L)= times TBW
                                                                                                                      • The rate of fluid administration
                                                                                                                      • Hyponatremia Nalt135mEqL
                                                                                                                      • Slide 74
                                                                                                                      • Sodium depletion
                                                                                                                      • Sodium dilution
                                                                                                                      • Sign and symptoms
                                                                                                                      • Slide 78
                                                                                                                      • Treatment
                                                                                                                      • Slide 80
                                                                                                                      • Slide 81
                                                                                                                      • Dose
                                                                                                                      • Potassium abnormalities
                                                                                                                      • Hyperkalemia
                                                                                                                      • Clinical manifestation of hyperkalemia
                                                                                                                      • Slide 86
                                                                                                                      • Slide 87
                                                                                                                      • Hypokalemia
                                                                                                                      • Potassium changes associated with alkalosis
                                                                                                                      • Slide 90
                                                                                                                      • Clinical Manifestation of Abnormalities in potassium
                                                                                                                      • Slide 92
                                                                                                                      • Calcium
                                                                                                                      • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                      • علائم هیپوکلسمی
                                                                                                                      • Slide 96
                                                                                                                      • Slide 97
                                                                                                                      • Slide 98
                                                                                                                      • Slide 99
                                                                                                                      • سایرعلائم
                                                                                                                      • درمان
                                                                                                                      • هيپركلسمي Cagt55meql
                                                                                                                      • علائم
                                                                                                                      • علائم قلبی
                                                                                                                      • Slide 105
                                                                                                                      • Magnesium Abnormalities
                                                                                                                      • منیزیوم
                                                                                                                      • Hypermagnesemia
                                                                                                                      • Clinical manifestation hypermanesemia
                                                                                                                      • Slide 110
                                                                                                                      • Slide 111
                                                                                                                      • Hypomagnesemia
                                                                                                                      • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                      • Slide 114
                                                                                                                      • Message for Today
                                                                                                                      • Slide 116

                                                                                                                        Electrolyte physiology

                                                                                                                        Sodium physiology

                                                                                                                        Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                                                        Normal amount 135-145 meql

                                                                                                                        Osmotic Pressure

                                                                                                                        Calculated serum osmolality =

                                                                                                                        2 sodium+ glucose18 + BUN 28

                                                                                                                        Osmolality = 290 mosm

                                                                                                                        Concentration

                                                                                                                        1Serum sodium concentration2Serum osmolarity

                                                                                                                        bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                                                        drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                                                        DW5)

                                                                                                                        Hypernatremia

                                                                                                                        Serum Nagt145mEqL

                                                                                                                        - Hypernatremia

                                                                                                                        Loss of Free Water

                                                                                                                        Gain of sodium in excess of water

                                                                                                                        Hypernatremia

                                                                                                                        -Hypernatremia Hypo volemic

                                                                                                                        Hyper volemic

                                                                                                                        Normo volemic

                                                                                                                        Hypernatremia

                                                                                                                        Volume Status

                                                                                                                        Normal

                                                                                                                        Nonrenal water loss

                                                                                                                        Skin

                                                                                                                        Gastrointestinal

                                                                                                                        Renal water loss

                                                                                                                        Renal disease

                                                                                                                        Diuretics

                                                                                                                        Diabetes insipidus

                                                                                                                        High

                                                                                                                        Iatrogenic sodium administration

                                                                                                                        Mineralocorticoid excess

                                                                                                                        Aldosteronism

                                                                                                                        Cushingrsquos disease

                                                                                                                        Congenital adrenal

                                                                                                                        hyperplasia

                                                                                                                        Low

                                                                                                                        Nonrenal water loss

                                                                                                                        Skin

                                                                                                                        Gastrointestinal losses

                                                                                                                        Renal water losses

                                                                                                                        Renal (tubular) Diuretics

                                                                                                                        Osmotic diuretics

                                                                                                                        Diabetes insipidus

                                                                                                                        Adrenal failure

                                                                                                                        Asymptomatic

                                                                                                                        Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                                        Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                        Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                                        Body system hypernatremia

                                                                                                                        Treatment

                                                                                                                        Normal saline in hypovolemic patients

                                                                                                                        Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                                        saline or entral water)

                                                                                                                        Water deficit (L)= times TBW

                                                                                                                        The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                                        Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                                        Serum sodium-140

                                                                                                                        140

                                                                                                                        The rate of fluid administration

                                                                                                                        1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                                        2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                                        Hyponatremia Nalt135mEqL

                                                                                                                        Causes

                                                                                                                        1 Sodium depletion

                                                                                                                        2 Sodium dilution

                                                                                                                        bull Incidence = 45

                                                                                                                        bull After surgery=1

                                                                                                                        bull Mortality = 2 times normal

                                                                                                                        Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                                        volume deficit

                                                                                                                        Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                        Sign and symptoms

                                                                                                                        bull CNS symptom when Nalt123 meql

                                                                                                                        bull Cardiac symptom when Nalt100 meql

                                                                                                                        For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                        Body System Hyponatremia

                                                                                                                        central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                        reflexes seizures coma increased intracranial pressure

                                                                                                                        Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                        Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                        Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                        intracranial pressure

                                                                                                                        Tissue Lacrimation salivation

                                                                                                                        Renal Oliguria

                                                                                                                        Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                        Treatment

                                                                                                                        1=Depend on ECF

                                                                                                                        2=CNS sign

                                                                                                                        Treatment

                                                                                                                        1 Asymptomatic increase the sodium level by no more than

                                                                                                                        05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                        2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                        more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                        meqL or neurologic symptoms are improved

                                                                                                                        Rapid correction of hyponatremia

                                                                                                                        Pontine myelinolysis

                                                                                                                        Seizures weaknessparesis akinetic

                                                                                                                        movements unresponsiveness

                                                                                                                        Permanent brain damage

                                                                                                                        Death

                                                                                                                        Dose

                                                                                                                        Na deficit meq =(140- Na meql) TBW

                                                                                                                        باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                        شود اصالح آهسته سپس

                                                                                                                        Potassium abnormalities

                                                                                                                        bull The average dietary intake of potassium 50-100meqd

                                                                                                                        bull The average renal excretion of potassium 10-700 meqd

                                                                                                                        - 2 of the total body potassium in ECF (45meqL)

                                                                                                                        - Factors that influence serum potassium

                                                                                                                        1 Surgical stress

                                                                                                                        2 Injury

                                                                                                                        3 Acidosis

                                                                                                                        4 Tissue catabolism

                                                                                                                        Hyperkalemia

                                                                                                                        The normal range of serum potassium 35-5 meqL

                                                                                                                        Etiology of Hyperkalemia

                                                                                                                        Increased intake Potassium supplementation

                                                                                                                        Blood transfusions

                                                                                                                        Endogenous loaddestruction

                                                                                                                        hemolysis rhabdomyolysis

                                                                                                                        cruch injury gastrointestinal hemorrhage

                                                                                                                        Increased release Acidosis

                                                                                                                        Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                        Renal insufficiencyfailure

                                                                                                                        Clinical manifestation of hyperkalemia

                                                                                                                        System hyperkalemia

                                                                                                                        Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                        Neuromuscular weakness paralysis respiratory failure

                                                                                                                        Cardiovascular Arrhythmia arrest

                                                                                                                        ECG changes Peaked T waves (early change)

                                                                                                                        Flattened P wave

                                                                                                                        Prolonged PR interval (first-degree block)

                                                                                                                        Widened QRS complex

                                                                                                                        Sine wave formation

                                                                                                                        Ventricular fibrillation

                                                                                                                        Treatment

                                                                                                                        Treatment of symptomatic hyperkalemia

                                                                                                                        Potassium removal Kayexalate

                                                                                                                        Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                        Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                        Dialysis

                                                                                                                        Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                        Bicarbonate 1 vial intravenous

                                                                                                                        Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                        HypokalemiaEtiology

                                                                                                                        inadequate intake

                                                                                                                        Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                        total parenteral nutrition

                                                                                                                        Excessive potassium excretion

                                                                                                                        Hyperaldosteronism

                                                                                                                        Medications

                                                                                                                        Gastrointestinal losses

                                                                                                                        Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                        Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                        nasogastric output)

                                                                                                                        Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                        Potassium changes associated with alkalosis

                                                                                                                        Potassium decrease by 03 meqL for every 01

                                                                                                                        increase in PH above normal

                                                                                                                        Magnesium Depletion

                                                                                                                        (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                        Renal potassium wastage

                                                                                                                        Hypokalemia

                                                                                                                        Magnesium Depletion

                                                                                                                        (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                        Renal potassium wastage

                                                                                                                        Hypokalemia

                                                                                                                        Clinical Manifestation of Abnormalities in potassium

                                                                                                                        System hypokalemia

                                                                                                                        Gastrointestinal Ileus constipation

                                                                                                                        Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                        paralysis

                                                                                                                        Cardiovascular Arrest

                                                                                                                        ECG changes U-waves

                                                                                                                        T-wave flattening

                                                                                                                        ST-segment changes

                                                                                                                        Arrhythmias

                                                                                                                        Treatment

                                                                                                                        Potassium

                                                                                                                        Serum potassium level lt40 mEqL

                                                                                                                        Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                        times 1 doses

                                                                                                                        Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                        Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                        Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                        asymptomatic replace as per above protocol

                                                                                                                        Electrolyte Replacement Therapy Protocol

                                                                                                                        bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                        bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                        Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                        ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                        عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                        صاف 2 عضالت انقباض

                                                                                                                        هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                        انعقاد 4

                                                                                                                        یونیزه Calt45 meql هيپوكلسمي

                                                                                                                        عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                        ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                        میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                        ( شود می پیوند شده

                                                                                                                        هیپوکلسمی عالئم

                                                                                                                        رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                        سایرعالئم

                                                                                                                        قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                        درمان

                                                                                                                        ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                        Cagt55meql هيپركلسمي

                                                                                                                        هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                        عالئم

                                                                                                                        bullGI

                                                                                                                        bullCardiovascular bullRenal (polyuria)

                                                                                                                        bullCNS

                                                                                                                        قلبی عالئم

                                                                                                                        bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                        QRS شدن )Q-Tوكوتاه

                                                                                                                        درمان

                                                                                                                        ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                        الزیکس2

                                                                                                                        تونین 3 کلسی

                                                                                                                        کورتون4

                                                                                                                        دیالیز5

                                                                                                                        Magnesium Abnormalities

                                                                                                                        Normal dietary intake 20meq (240mg)

                                                                                                                        Excretion in both the feces and urine

                                                                                                                        Normal serum level 19-25 mgdL

                                                                                                                        منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                        تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                        bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                        Hypermagnesemia

                                                                                                                        Etiology

                                                                                                                        1 Impaired renal function

                                                                                                                        2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                        Clinical manifestation hypermanesemia

                                                                                                                        System hypermanesemia

                                                                                                                        Gastrointestinal Nauseavomiting

                                                                                                                        Neuromuscular weakness lethargy Decreased

                                                                                                                        reflexes

                                                                                                                        Cardiovascular Hypotension arrest

                                                                                                                        ECG changes Increased PR interval

                                                                                                                        Widened QRS complex

                                                                                                                        Elevated T waves

                                                                                                                        Treatment

                                                                                                                        1 Withhold exogenous sources of magnesium

                                                                                                                        2 Correct volume deficit

                                                                                                                        3 Correct acidosis if present

                                                                                                                        4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                        5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                        عالئم

                                                                                                                        bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                        meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                        meqL

                                                                                                                        Hypomagnesemia

                                                                                                                        Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                        homeostasis

                                                                                                                        Etiology

                                                                                                                        1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                        inadequate supplementation of magnesium)

                                                                                                                        2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                        3 GI losses (diarrhea)

                                                                                                                        4 Malabsorption

                                                                                                                        5 Acute pancreatitis

                                                                                                                        6 Diabetic ketoacidosis

                                                                                                                        7 Primary aldosteronism

                                                                                                                        Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                        1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                        2 Delirium and seizures in severe deficiency

                                                                                                                        3 ECG changes Prolonged QT and PR interval

                                                                                                                        ST-segment depression

                                                                                                                        Flattening or inversion of P waves

                                                                                                                        Torsades de pointes

                                                                                                                        Arrhythmia

                                                                                                                        Treatment

                                                                                                                        1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                        2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                        Message for Today

                                                                                                                        ICF

                                                                                                                        Interstitial

                                                                                                                        Pla

                                                                                                                        sma

                                                                                                                        5 Dex

                                                                                                                        bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                        • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                        • Slide 2
                                                                                                                        • Slide 3
                                                                                                                        • Slide 4
                                                                                                                        • Total Body Water
                                                                                                                        • Body Fluid Compartments
                                                                                                                        • Total body water (TBW)
                                                                                                                        • Body compartment fluid
                                                                                                                        • Example men with 70kg
                                                                                                                        • Fluid compartments
                                                                                                                        • Slide 11
                                                                                                                        • Slide 12
                                                                                                                        • Slide 13
                                                                                                                        • Slide 14
                                                                                                                        • Slide 15
                                                                                                                        • Colloid osmotic pressure
                                                                                                                        • Slide 17
                                                                                                                        • Slide 18
                                                                                                                        • Slide 19
                                                                                                                        • Cell Membrane
                                                                                                                        • Slide 21
                                                                                                                        • Slide 22
                                                                                                                        • Slide 23
                                                                                                                        • Slide 24
                                                                                                                        • Slide 25
                                                                                                                        • Composition of Fluid Compartments
                                                                                                                        • Composition of Body Fluids
                                                                                                                        • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                        • Reasons for fluid therapy
                                                                                                                        • ارزیابی حجم مایع داخل عروقی
                                                                                                                        • محلولهای وریدی
                                                                                                                        • Fluids
                                                                                                                        • Slide 33
                                                                                                                        • Slide 34
                                                                                                                        • Slide 35
                                                                                                                        • Crystalloids
                                                                                                                        • Colloid Solutions
                                                                                                                        • رینگر لاکتات
                                                                                                                        • 09Nacl
                                                                                                                        • Postoperative (maintenance)
                                                                                                                        • Slide 41
                                                                                                                        • Preexisting fluid deficits
                                                                                                                        • Maintenance requirements
                                                                                                                        • Surgical fluid losses
                                                                                                                        • Third space loss
                                                                                                                        • Crystalloid solution
                                                                                                                        • Colloids
                                                                                                                        • Complications
                                                                                                                        • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                        • Colloid versus crystalloid solutions
                                                                                                                        • Transfusion consideration
                                                                                                                        • اختلال در حجم مایعات بدن
                                                                                                                        • Fluid volume deficit (FVD)
                                                                                                                        • DEHYDRATION
                                                                                                                        • علل کاهش حجم خارج سلولی
                                                                                                                        • Signs of Hypovolemia
                                                                                                                        • Clinical Diagnosis of Hypovolemia
                                                                                                                        • Signs of Hypervolemia
                                                                                                                        • Management of Hypervolemia
                                                                                                                        • Fluid Management
                                                                                                                        • Electrolyte physiology
                                                                                                                        • Sodium physiology
                                                                                                                        • Osmotic Pressure
                                                                                                                        • Concentration
                                                                                                                        • Hypernatremia
                                                                                                                        • - Hypernatremia
                                                                                                                        • Slide 67
                                                                                                                        • Slide 68
                                                                                                                        • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                        • Treatment
                                                                                                                        • Water deficit (L)= times TBW
                                                                                                                        • The rate of fluid administration
                                                                                                                        • Hyponatremia Nalt135mEqL
                                                                                                                        • Slide 74
                                                                                                                        • Sodium depletion
                                                                                                                        • Sodium dilution
                                                                                                                        • Sign and symptoms
                                                                                                                        • Slide 78
                                                                                                                        • Treatment
                                                                                                                        • Slide 80
                                                                                                                        • Slide 81
                                                                                                                        • Dose
                                                                                                                        • Potassium abnormalities
                                                                                                                        • Hyperkalemia
                                                                                                                        • Clinical manifestation of hyperkalemia
                                                                                                                        • Slide 86
                                                                                                                        • Slide 87
                                                                                                                        • Hypokalemia
                                                                                                                        • Potassium changes associated with alkalosis
                                                                                                                        • Slide 90
                                                                                                                        • Clinical Manifestation of Abnormalities in potassium
                                                                                                                        • Slide 92
                                                                                                                        • Calcium
                                                                                                                        • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                        • علائم هیپوکلسمی
                                                                                                                        • Slide 96
                                                                                                                        • Slide 97
                                                                                                                        • Slide 98
                                                                                                                        • Slide 99
                                                                                                                        • سایرعلائم
                                                                                                                        • درمان
                                                                                                                        • هيپركلسمي Cagt55meql
                                                                                                                        • علائم
                                                                                                                        • علائم قلبی
                                                                                                                        • Slide 105
                                                                                                                        • Magnesium Abnormalities
                                                                                                                        • منیزیوم
                                                                                                                        • Hypermagnesemia
                                                                                                                        • Clinical manifestation hypermanesemia
                                                                                                                        • Slide 110
                                                                                                                        • Slide 111
                                                                                                                        • Hypomagnesemia
                                                                                                                        • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                        • Slide 114
                                                                                                                        • Message for Today
                                                                                                                        • Slide 116

                                                                                                                          Sodium physiology

                                                                                                                          Na is the most abundant positive ion of ECF compartment and is critical in determining the ECF and ICF osmolality

                                                                                                                          Normal amount 135-145 meql

                                                                                                                          Osmotic Pressure

                                                                                                                          Calculated serum osmolality =

                                                                                                                          2 sodium+ glucose18 + BUN 28

                                                                                                                          Osmolality = 290 mosm

                                                                                                                          Concentration

                                                                                                                          1Serum sodium concentration2Serum osmolarity

                                                                                                                          bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                                                          drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                                                          DW5)

                                                                                                                          Hypernatremia

                                                                                                                          Serum Nagt145mEqL

                                                                                                                          - Hypernatremia

                                                                                                                          Loss of Free Water

                                                                                                                          Gain of sodium in excess of water

                                                                                                                          Hypernatremia

                                                                                                                          -Hypernatremia Hypo volemic

                                                                                                                          Hyper volemic

                                                                                                                          Normo volemic

                                                                                                                          Hypernatremia

                                                                                                                          Volume Status

                                                                                                                          Normal

                                                                                                                          Nonrenal water loss

                                                                                                                          Skin

                                                                                                                          Gastrointestinal

                                                                                                                          Renal water loss

                                                                                                                          Renal disease

                                                                                                                          Diuretics

                                                                                                                          Diabetes insipidus

                                                                                                                          High

                                                                                                                          Iatrogenic sodium administration

                                                                                                                          Mineralocorticoid excess

                                                                                                                          Aldosteronism

                                                                                                                          Cushingrsquos disease

                                                                                                                          Congenital adrenal

                                                                                                                          hyperplasia

                                                                                                                          Low

                                                                                                                          Nonrenal water loss

                                                                                                                          Skin

                                                                                                                          Gastrointestinal losses

                                                                                                                          Renal water losses

                                                                                                                          Renal (tubular) Diuretics

                                                                                                                          Osmotic diuretics

                                                                                                                          Diabetes insipidus

                                                                                                                          Adrenal failure

                                                                                                                          Asymptomatic

                                                                                                                          Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                                          Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                          Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                                          Body system hypernatremia

                                                                                                                          Treatment

                                                                                                                          Normal saline in hypovolemic patients

                                                                                                                          Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                                          saline or entral water)

                                                                                                                          Water deficit (L)= times TBW

                                                                                                                          The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                                          Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                                          Serum sodium-140

                                                                                                                          140

                                                                                                                          The rate of fluid administration

                                                                                                                          1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                                          2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                                          Hyponatremia Nalt135mEqL

                                                                                                                          Causes

                                                                                                                          1 Sodium depletion

                                                                                                                          2 Sodium dilution

                                                                                                                          bull Incidence = 45

                                                                                                                          bull After surgery=1

                                                                                                                          bull Mortality = 2 times normal

                                                                                                                          Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                                          volume deficit

                                                                                                                          Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                          Sign and symptoms

                                                                                                                          bull CNS symptom when Nalt123 meql

                                                                                                                          bull Cardiac symptom when Nalt100 meql

                                                                                                                          For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                          Body System Hyponatremia

                                                                                                                          central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                          reflexes seizures coma increased intracranial pressure

                                                                                                                          Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                          Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                          Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                          intracranial pressure

                                                                                                                          Tissue Lacrimation salivation

                                                                                                                          Renal Oliguria

                                                                                                                          Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                          Treatment

                                                                                                                          1=Depend on ECF

                                                                                                                          2=CNS sign

                                                                                                                          Treatment

                                                                                                                          1 Asymptomatic increase the sodium level by no more than

                                                                                                                          05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                          2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                          more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                          meqL or neurologic symptoms are improved

                                                                                                                          Rapid correction of hyponatremia

                                                                                                                          Pontine myelinolysis

                                                                                                                          Seizures weaknessparesis akinetic

                                                                                                                          movements unresponsiveness

                                                                                                                          Permanent brain damage

                                                                                                                          Death

                                                                                                                          Dose

                                                                                                                          Na deficit meq =(140- Na meql) TBW

                                                                                                                          باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                          شود اصالح آهسته سپس

                                                                                                                          Potassium abnormalities

                                                                                                                          bull The average dietary intake of potassium 50-100meqd

                                                                                                                          bull The average renal excretion of potassium 10-700 meqd

                                                                                                                          - 2 of the total body potassium in ECF (45meqL)

                                                                                                                          - Factors that influence serum potassium

                                                                                                                          1 Surgical stress

                                                                                                                          2 Injury

                                                                                                                          3 Acidosis

                                                                                                                          4 Tissue catabolism

                                                                                                                          Hyperkalemia

                                                                                                                          The normal range of serum potassium 35-5 meqL

                                                                                                                          Etiology of Hyperkalemia

                                                                                                                          Increased intake Potassium supplementation

                                                                                                                          Blood transfusions

                                                                                                                          Endogenous loaddestruction

                                                                                                                          hemolysis rhabdomyolysis

                                                                                                                          cruch injury gastrointestinal hemorrhage

                                                                                                                          Increased release Acidosis

                                                                                                                          Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                          Renal insufficiencyfailure

                                                                                                                          Clinical manifestation of hyperkalemia

                                                                                                                          System hyperkalemia

                                                                                                                          Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                          Neuromuscular weakness paralysis respiratory failure

                                                                                                                          Cardiovascular Arrhythmia arrest

                                                                                                                          ECG changes Peaked T waves (early change)

                                                                                                                          Flattened P wave

                                                                                                                          Prolonged PR interval (first-degree block)

                                                                                                                          Widened QRS complex

                                                                                                                          Sine wave formation

                                                                                                                          Ventricular fibrillation

                                                                                                                          Treatment

                                                                                                                          Treatment of symptomatic hyperkalemia

                                                                                                                          Potassium removal Kayexalate

                                                                                                                          Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                          Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                          Dialysis

                                                                                                                          Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                          Bicarbonate 1 vial intravenous

                                                                                                                          Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                          HypokalemiaEtiology

                                                                                                                          inadequate intake

                                                                                                                          Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                          total parenteral nutrition

                                                                                                                          Excessive potassium excretion

                                                                                                                          Hyperaldosteronism

                                                                                                                          Medications

                                                                                                                          Gastrointestinal losses

                                                                                                                          Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                          Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                          nasogastric output)

                                                                                                                          Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                          Potassium changes associated with alkalosis

                                                                                                                          Potassium decrease by 03 meqL for every 01

                                                                                                                          increase in PH above normal

                                                                                                                          Magnesium Depletion

                                                                                                                          (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                          Renal potassium wastage

                                                                                                                          Hypokalemia

                                                                                                                          Magnesium Depletion

                                                                                                                          (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                          Renal potassium wastage

                                                                                                                          Hypokalemia

                                                                                                                          Clinical Manifestation of Abnormalities in potassium

                                                                                                                          System hypokalemia

                                                                                                                          Gastrointestinal Ileus constipation

                                                                                                                          Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                          paralysis

                                                                                                                          Cardiovascular Arrest

                                                                                                                          ECG changes U-waves

                                                                                                                          T-wave flattening

                                                                                                                          ST-segment changes

                                                                                                                          Arrhythmias

                                                                                                                          Treatment

                                                                                                                          Potassium

                                                                                                                          Serum potassium level lt40 mEqL

                                                                                                                          Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                          times 1 doses

                                                                                                                          Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                          Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                          Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                          asymptomatic replace as per above protocol

                                                                                                                          Electrolyte Replacement Therapy Protocol

                                                                                                                          bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                          bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                          Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                          ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                          عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                          صاف 2 عضالت انقباض

                                                                                                                          هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                          انعقاد 4

                                                                                                                          یونیزه Calt45 meql هيپوكلسمي

                                                                                                                          عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                          ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                          میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                          ( شود می پیوند شده

                                                                                                                          هیپوکلسمی عالئم

                                                                                                                          رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                          سایرعالئم

                                                                                                                          قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                          درمان

                                                                                                                          ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                          Cagt55meql هيپركلسمي

                                                                                                                          هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                          عالئم

                                                                                                                          bullGI

                                                                                                                          bullCardiovascular bullRenal (polyuria)

                                                                                                                          bullCNS

                                                                                                                          قلبی عالئم

                                                                                                                          bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                          QRS شدن )Q-Tوكوتاه

                                                                                                                          درمان

                                                                                                                          ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                          الزیکس2

                                                                                                                          تونین 3 کلسی

                                                                                                                          کورتون4

                                                                                                                          دیالیز5

                                                                                                                          Magnesium Abnormalities

                                                                                                                          Normal dietary intake 20meq (240mg)

                                                                                                                          Excretion in both the feces and urine

                                                                                                                          Normal serum level 19-25 mgdL

                                                                                                                          منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                          تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                          bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                          Hypermagnesemia

                                                                                                                          Etiology

                                                                                                                          1 Impaired renal function

                                                                                                                          2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                          Clinical manifestation hypermanesemia

                                                                                                                          System hypermanesemia

                                                                                                                          Gastrointestinal Nauseavomiting

                                                                                                                          Neuromuscular weakness lethargy Decreased

                                                                                                                          reflexes

                                                                                                                          Cardiovascular Hypotension arrest

                                                                                                                          ECG changes Increased PR interval

                                                                                                                          Widened QRS complex

                                                                                                                          Elevated T waves

                                                                                                                          Treatment

                                                                                                                          1 Withhold exogenous sources of magnesium

                                                                                                                          2 Correct volume deficit

                                                                                                                          3 Correct acidosis if present

                                                                                                                          4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                          5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                          عالئم

                                                                                                                          bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                          meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                          meqL

                                                                                                                          Hypomagnesemia

                                                                                                                          Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                          homeostasis

                                                                                                                          Etiology

                                                                                                                          1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                          inadequate supplementation of magnesium)

                                                                                                                          2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                          3 GI losses (diarrhea)

                                                                                                                          4 Malabsorption

                                                                                                                          5 Acute pancreatitis

                                                                                                                          6 Diabetic ketoacidosis

                                                                                                                          7 Primary aldosteronism

                                                                                                                          Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                          1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                          2 Delirium and seizures in severe deficiency

                                                                                                                          3 ECG changes Prolonged QT and PR interval

                                                                                                                          ST-segment depression

                                                                                                                          Flattening or inversion of P waves

                                                                                                                          Torsades de pointes

                                                                                                                          Arrhythmia

                                                                                                                          Treatment

                                                                                                                          1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                          2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                          Message for Today

                                                                                                                          ICF

                                                                                                                          Interstitial

                                                                                                                          Pla

                                                                                                                          sma

                                                                                                                          5 Dex

                                                                                                                          bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                          • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                          • Slide 2
                                                                                                                          • Slide 3
                                                                                                                          • Slide 4
                                                                                                                          • Total Body Water
                                                                                                                          • Body Fluid Compartments
                                                                                                                          • Total body water (TBW)
                                                                                                                          • Body compartment fluid
                                                                                                                          • Example men with 70kg
                                                                                                                          • Fluid compartments
                                                                                                                          • Slide 11
                                                                                                                          • Slide 12
                                                                                                                          • Slide 13
                                                                                                                          • Slide 14
                                                                                                                          • Slide 15
                                                                                                                          • Colloid osmotic pressure
                                                                                                                          • Slide 17
                                                                                                                          • Slide 18
                                                                                                                          • Slide 19
                                                                                                                          • Cell Membrane
                                                                                                                          • Slide 21
                                                                                                                          • Slide 22
                                                                                                                          • Slide 23
                                                                                                                          • Slide 24
                                                                                                                          • Slide 25
                                                                                                                          • Composition of Fluid Compartments
                                                                                                                          • Composition of Body Fluids
                                                                                                                          • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                          • Reasons for fluid therapy
                                                                                                                          • ارزیابی حجم مایع داخل عروقی
                                                                                                                          • محلولهای وریدی
                                                                                                                          • Fluids
                                                                                                                          • Slide 33
                                                                                                                          • Slide 34
                                                                                                                          • Slide 35
                                                                                                                          • Crystalloids
                                                                                                                          • Colloid Solutions
                                                                                                                          • رینگر لاکتات
                                                                                                                          • 09Nacl
                                                                                                                          • Postoperative (maintenance)
                                                                                                                          • Slide 41
                                                                                                                          • Preexisting fluid deficits
                                                                                                                          • Maintenance requirements
                                                                                                                          • Surgical fluid losses
                                                                                                                          • Third space loss
                                                                                                                          • Crystalloid solution
                                                                                                                          • Colloids
                                                                                                                          • Complications
                                                                                                                          • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                          • Colloid versus crystalloid solutions
                                                                                                                          • Transfusion consideration
                                                                                                                          • اختلال در حجم مایعات بدن
                                                                                                                          • Fluid volume deficit (FVD)
                                                                                                                          • DEHYDRATION
                                                                                                                          • علل کاهش حجم خارج سلولی
                                                                                                                          • Signs of Hypovolemia
                                                                                                                          • Clinical Diagnosis of Hypovolemia
                                                                                                                          • Signs of Hypervolemia
                                                                                                                          • Management of Hypervolemia
                                                                                                                          • Fluid Management
                                                                                                                          • Electrolyte physiology
                                                                                                                          • Sodium physiology
                                                                                                                          • Osmotic Pressure
                                                                                                                          • Concentration
                                                                                                                          • Hypernatremia
                                                                                                                          • - Hypernatremia
                                                                                                                          • Slide 67
                                                                                                                          • Slide 68
                                                                                                                          • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                          • Treatment
                                                                                                                          • Water deficit (L)= times TBW
                                                                                                                          • The rate of fluid administration
                                                                                                                          • Hyponatremia Nalt135mEqL
                                                                                                                          • Slide 74
                                                                                                                          • Sodium depletion
                                                                                                                          • Sodium dilution
                                                                                                                          • Sign and symptoms
                                                                                                                          • Slide 78
                                                                                                                          • Treatment
                                                                                                                          • Slide 80
                                                                                                                          • Slide 81
                                                                                                                          • Dose
                                                                                                                          • Potassium abnormalities
                                                                                                                          • Hyperkalemia
                                                                                                                          • Clinical manifestation of hyperkalemia
                                                                                                                          • Slide 86
                                                                                                                          • Slide 87
                                                                                                                          • Hypokalemia
                                                                                                                          • Potassium changes associated with alkalosis
                                                                                                                          • Slide 90
                                                                                                                          • Clinical Manifestation of Abnormalities in potassium
                                                                                                                          • Slide 92
                                                                                                                          • Calcium
                                                                                                                          • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                          • علائم هیپوکلسمی
                                                                                                                          • Slide 96
                                                                                                                          • Slide 97
                                                                                                                          • Slide 98
                                                                                                                          • Slide 99
                                                                                                                          • سایرعلائم
                                                                                                                          • درمان
                                                                                                                          • هيپركلسمي Cagt55meql
                                                                                                                          • علائم
                                                                                                                          • علائم قلبی
                                                                                                                          • Slide 105
                                                                                                                          • Magnesium Abnormalities
                                                                                                                          • منیزیوم
                                                                                                                          • Hypermagnesemia
                                                                                                                          • Clinical manifestation hypermanesemia
                                                                                                                          • Slide 110
                                                                                                                          • Slide 111
                                                                                                                          • Hypomagnesemia
                                                                                                                          • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                          • Slide 114
                                                                                                                          • Message for Today
                                                                                                                          • Slide 116

                                                                                                                            Osmotic Pressure

                                                                                                                            Calculated serum osmolality =

                                                                                                                            2 sodium+ glucose18 + BUN 28

                                                                                                                            Osmolality = 290 mosm

                                                                                                                            Concentration

                                                                                                                            1Serum sodium concentration2Serum osmolarity

                                                                                                                            bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                                                            drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                                                            DW5)

                                                                                                                            Hypernatremia

                                                                                                                            Serum Nagt145mEqL

                                                                                                                            - Hypernatremia

                                                                                                                            Loss of Free Water

                                                                                                                            Gain of sodium in excess of water

                                                                                                                            Hypernatremia

                                                                                                                            -Hypernatremia Hypo volemic

                                                                                                                            Hyper volemic

                                                                                                                            Normo volemic

                                                                                                                            Hypernatremia

                                                                                                                            Volume Status

                                                                                                                            Normal

                                                                                                                            Nonrenal water loss

                                                                                                                            Skin

                                                                                                                            Gastrointestinal

                                                                                                                            Renal water loss

                                                                                                                            Renal disease

                                                                                                                            Diuretics

                                                                                                                            Diabetes insipidus

                                                                                                                            High

                                                                                                                            Iatrogenic sodium administration

                                                                                                                            Mineralocorticoid excess

                                                                                                                            Aldosteronism

                                                                                                                            Cushingrsquos disease

                                                                                                                            Congenital adrenal

                                                                                                                            hyperplasia

                                                                                                                            Low

                                                                                                                            Nonrenal water loss

                                                                                                                            Skin

                                                                                                                            Gastrointestinal losses

                                                                                                                            Renal water losses

                                                                                                                            Renal (tubular) Diuretics

                                                                                                                            Osmotic diuretics

                                                                                                                            Diabetes insipidus

                                                                                                                            Adrenal failure

                                                                                                                            Asymptomatic

                                                                                                                            Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                                            Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                            Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                                            Body system hypernatremia

                                                                                                                            Treatment

                                                                                                                            Normal saline in hypovolemic patients

                                                                                                                            Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                                            saline or entral water)

                                                                                                                            Water deficit (L)= times TBW

                                                                                                                            The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                                            Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                                            Serum sodium-140

                                                                                                                            140

                                                                                                                            The rate of fluid administration

                                                                                                                            1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                                            2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                                            Hyponatremia Nalt135mEqL

                                                                                                                            Causes

                                                                                                                            1 Sodium depletion

                                                                                                                            2 Sodium dilution

                                                                                                                            bull Incidence = 45

                                                                                                                            bull After surgery=1

                                                                                                                            bull Mortality = 2 times normal

                                                                                                                            Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                                            volume deficit

                                                                                                                            Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                            Sign and symptoms

                                                                                                                            bull CNS symptom when Nalt123 meql

                                                                                                                            bull Cardiac symptom when Nalt100 meql

                                                                                                                            For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                            Body System Hyponatremia

                                                                                                                            central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                            reflexes seizures coma increased intracranial pressure

                                                                                                                            Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                            Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                            Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                            intracranial pressure

                                                                                                                            Tissue Lacrimation salivation

                                                                                                                            Renal Oliguria

                                                                                                                            Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                            Treatment

                                                                                                                            1=Depend on ECF

                                                                                                                            2=CNS sign

                                                                                                                            Treatment

                                                                                                                            1 Asymptomatic increase the sodium level by no more than

                                                                                                                            05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                            2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                            more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                            meqL or neurologic symptoms are improved

                                                                                                                            Rapid correction of hyponatremia

                                                                                                                            Pontine myelinolysis

                                                                                                                            Seizures weaknessparesis akinetic

                                                                                                                            movements unresponsiveness

                                                                                                                            Permanent brain damage

                                                                                                                            Death

                                                                                                                            Dose

                                                                                                                            Na deficit meq =(140- Na meql) TBW

                                                                                                                            باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                            شود اصالح آهسته سپس

                                                                                                                            Potassium abnormalities

                                                                                                                            bull The average dietary intake of potassium 50-100meqd

                                                                                                                            bull The average renal excretion of potassium 10-700 meqd

                                                                                                                            - 2 of the total body potassium in ECF (45meqL)

                                                                                                                            - Factors that influence serum potassium

                                                                                                                            1 Surgical stress

                                                                                                                            2 Injury

                                                                                                                            3 Acidosis

                                                                                                                            4 Tissue catabolism

                                                                                                                            Hyperkalemia

                                                                                                                            The normal range of serum potassium 35-5 meqL

                                                                                                                            Etiology of Hyperkalemia

                                                                                                                            Increased intake Potassium supplementation

                                                                                                                            Blood transfusions

                                                                                                                            Endogenous loaddestruction

                                                                                                                            hemolysis rhabdomyolysis

                                                                                                                            cruch injury gastrointestinal hemorrhage

                                                                                                                            Increased release Acidosis

                                                                                                                            Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                            Renal insufficiencyfailure

                                                                                                                            Clinical manifestation of hyperkalemia

                                                                                                                            System hyperkalemia

                                                                                                                            Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                            Neuromuscular weakness paralysis respiratory failure

                                                                                                                            Cardiovascular Arrhythmia arrest

                                                                                                                            ECG changes Peaked T waves (early change)

                                                                                                                            Flattened P wave

                                                                                                                            Prolonged PR interval (first-degree block)

                                                                                                                            Widened QRS complex

                                                                                                                            Sine wave formation

                                                                                                                            Ventricular fibrillation

                                                                                                                            Treatment

                                                                                                                            Treatment of symptomatic hyperkalemia

                                                                                                                            Potassium removal Kayexalate

                                                                                                                            Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                            Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                            Dialysis

                                                                                                                            Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                            Bicarbonate 1 vial intravenous

                                                                                                                            Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                            HypokalemiaEtiology

                                                                                                                            inadequate intake

                                                                                                                            Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                            total parenteral nutrition

                                                                                                                            Excessive potassium excretion

                                                                                                                            Hyperaldosteronism

                                                                                                                            Medications

                                                                                                                            Gastrointestinal losses

                                                                                                                            Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                            Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                            nasogastric output)

                                                                                                                            Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                            Potassium changes associated with alkalosis

                                                                                                                            Potassium decrease by 03 meqL for every 01

                                                                                                                            increase in PH above normal

                                                                                                                            Magnesium Depletion

                                                                                                                            (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                            Renal potassium wastage

                                                                                                                            Hypokalemia

                                                                                                                            Magnesium Depletion

                                                                                                                            (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                            Renal potassium wastage

                                                                                                                            Hypokalemia

                                                                                                                            Clinical Manifestation of Abnormalities in potassium

                                                                                                                            System hypokalemia

                                                                                                                            Gastrointestinal Ileus constipation

                                                                                                                            Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                            paralysis

                                                                                                                            Cardiovascular Arrest

                                                                                                                            ECG changes U-waves

                                                                                                                            T-wave flattening

                                                                                                                            ST-segment changes

                                                                                                                            Arrhythmias

                                                                                                                            Treatment

                                                                                                                            Potassium

                                                                                                                            Serum potassium level lt40 mEqL

                                                                                                                            Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                            times 1 doses

                                                                                                                            Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                            Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                            Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                            asymptomatic replace as per above protocol

                                                                                                                            Electrolyte Replacement Therapy Protocol

                                                                                                                            bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                            bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                            Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                            ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                            عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                            صاف 2 عضالت انقباض

                                                                                                                            هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                            انعقاد 4

                                                                                                                            یونیزه Calt45 meql هيپوكلسمي

                                                                                                                            عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                            ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                            میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                            ( شود می پیوند شده

                                                                                                                            هیپوکلسمی عالئم

                                                                                                                            رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                            سایرعالئم

                                                                                                                            قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                            درمان

                                                                                                                            ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                            Cagt55meql هيپركلسمي

                                                                                                                            هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                            عالئم

                                                                                                                            bullGI

                                                                                                                            bullCardiovascular bullRenal (polyuria)

                                                                                                                            bullCNS

                                                                                                                            قلبی عالئم

                                                                                                                            bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                            QRS شدن )Q-Tوكوتاه

                                                                                                                            درمان

                                                                                                                            ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                            الزیکس2

                                                                                                                            تونین 3 کلسی

                                                                                                                            کورتون4

                                                                                                                            دیالیز5

                                                                                                                            Magnesium Abnormalities

                                                                                                                            Normal dietary intake 20meq (240mg)

                                                                                                                            Excretion in both the feces and urine

                                                                                                                            Normal serum level 19-25 mgdL

                                                                                                                            منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                            تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                            bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                            Hypermagnesemia

                                                                                                                            Etiology

                                                                                                                            1 Impaired renal function

                                                                                                                            2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                            Clinical manifestation hypermanesemia

                                                                                                                            System hypermanesemia

                                                                                                                            Gastrointestinal Nauseavomiting

                                                                                                                            Neuromuscular weakness lethargy Decreased

                                                                                                                            reflexes

                                                                                                                            Cardiovascular Hypotension arrest

                                                                                                                            ECG changes Increased PR interval

                                                                                                                            Widened QRS complex

                                                                                                                            Elevated T waves

                                                                                                                            Treatment

                                                                                                                            1 Withhold exogenous sources of magnesium

                                                                                                                            2 Correct volume deficit

                                                                                                                            3 Correct acidosis if present

                                                                                                                            4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                            5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                            عالئم

                                                                                                                            bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                            meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                            meqL

                                                                                                                            Hypomagnesemia

                                                                                                                            Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                            homeostasis

                                                                                                                            Etiology

                                                                                                                            1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                            inadequate supplementation of magnesium)

                                                                                                                            2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                            3 GI losses (diarrhea)

                                                                                                                            4 Malabsorption

                                                                                                                            5 Acute pancreatitis

                                                                                                                            6 Diabetic ketoacidosis

                                                                                                                            7 Primary aldosteronism

                                                                                                                            Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                            1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                            2 Delirium and seizures in severe deficiency

                                                                                                                            3 ECG changes Prolonged QT and PR interval

                                                                                                                            ST-segment depression

                                                                                                                            Flattening or inversion of P waves

                                                                                                                            Torsades de pointes

                                                                                                                            Arrhythmia

                                                                                                                            Treatment

                                                                                                                            1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                            2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                            Message for Today

                                                                                                                            ICF

                                                                                                                            Interstitial

                                                                                                                            Pla

                                                                                                                            sma

                                                                                                                            5 Dex

                                                                                                                            bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                            • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                            • Slide 2
                                                                                                                            • Slide 3
                                                                                                                            • Slide 4
                                                                                                                            • Total Body Water
                                                                                                                            • Body Fluid Compartments
                                                                                                                            • Total body water (TBW)
                                                                                                                            • Body compartment fluid
                                                                                                                            • Example men with 70kg
                                                                                                                            • Fluid compartments
                                                                                                                            • Slide 11
                                                                                                                            • Slide 12
                                                                                                                            • Slide 13
                                                                                                                            • Slide 14
                                                                                                                            • Slide 15
                                                                                                                            • Colloid osmotic pressure
                                                                                                                            • Slide 17
                                                                                                                            • Slide 18
                                                                                                                            • Slide 19
                                                                                                                            • Cell Membrane
                                                                                                                            • Slide 21
                                                                                                                            • Slide 22
                                                                                                                            • Slide 23
                                                                                                                            • Slide 24
                                                                                                                            • Slide 25
                                                                                                                            • Composition of Fluid Compartments
                                                                                                                            • Composition of Body Fluids
                                                                                                                            • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                            • Reasons for fluid therapy
                                                                                                                            • ارزیابی حجم مایع داخل عروقی
                                                                                                                            • محلولهای وریدی
                                                                                                                            • Fluids
                                                                                                                            • Slide 33
                                                                                                                            • Slide 34
                                                                                                                            • Slide 35
                                                                                                                            • Crystalloids
                                                                                                                            • Colloid Solutions
                                                                                                                            • رینگر لاکتات
                                                                                                                            • 09Nacl
                                                                                                                            • Postoperative (maintenance)
                                                                                                                            • Slide 41
                                                                                                                            • Preexisting fluid deficits
                                                                                                                            • Maintenance requirements
                                                                                                                            • Surgical fluid losses
                                                                                                                            • Third space loss
                                                                                                                            • Crystalloid solution
                                                                                                                            • Colloids
                                                                                                                            • Complications
                                                                                                                            • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                            • Colloid versus crystalloid solutions
                                                                                                                            • Transfusion consideration
                                                                                                                            • اختلال در حجم مایعات بدن
                                                                                                                            • Fluid volume deficit (FVD)
                                                                                                                            • DEHYDRATION
                                                                                                                            • علل کاهش حجم خارج سلولی
                                                                                                                            • Signs of Hypovolemia
                                                                                                                            • Clinical Diagnosis of Hypovolemia
                                                                                                                            • Signs of Hypervolemia
                                                                                                                            • Management of Hypervolemia
                                                                                                                            • Fluid Management
                                                                                                                            • Electrolyte physiology
                                                                                                                            • Sodium physiology
                                                                                                                            • Osmotic Pressure
                                                                                                                            • Concentration
                                                                                                                            • Hypernatremia
                                                                                                                            • - Hypernatremia
                                                                                                                            • Slide 67
                                                                                                                            • Slide 68
                                                                                                                            • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                            • Treatment
                                                                                                                            • Water deficit (L)= times TBW
                                                                                                                            • The rate of fluid administration
                                                                                                                            • Hyponatremia Nalt135mEqL
                                                                                                                            • Slide 74
                                                                                                                            • Sodium depletion
                                                                                                                            • Sodium dilution
                                                                                                                            • Sign and symptoms
                                                                                                                            • Slide 78
                                                                                                                            • Treatment
                                                                                                                            • Slide 80
                                                                                                                            • Slide 81
                                                                                                                            • Dose
                                                                                                                            • Potassium abnormalities
                                                                                                                            • Hyperkalemia
                                                                                                                            • Clinical manifestation of hyperkalemia
                                                                                                                            • Slide 86
                                                                                                                            • Slide 87
                                                                                                                            • Hypokalemia
                                                                                                                            • Potassium changes associated with alkalosis
                                                                                                                            • Slide 90
                                                                                                                            • Clinical Manifestation of Abnormalities in potassium
                                                                                                                            • Slide 92
                                                                                                                            • Calcium
                                                                                                                            • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                            • علائم هیپوکلسمی
                                                                                                                            • Slide 96
                                                                                                                            • Slide 97
                                                                                                                            • Slide 98
                                                                                                                            • Slide 99
                                                                                                                            • سایرعلائم
                                                                                                                            • درمان
                                                                                                                            • هيپركلسمي Cagt55meql
                                                                                                                            • علائم
                                                                                                                            • علائم قلبی
                                                                                                                            • Slide 105
                                                                                                                            • Magnesium Abnormalities
                                                                                                                            • منیزیوم
                                                                                                                            • Hypermagnesemia
                                                                                                                            • Clinical manifestation hypermanesemia
                                                                                                                            • Slide 110
                                                                                                                            • Slide 111
                                                                                                                            • Hypomagnesemia
                                                                                                                            • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                            • Slide 114
                                                                                                                            • Message for Today
                                                                                                                            • Slide 116

                                                                                                                              Concentration

                                                                                                                              1Serum sodium concentration2Serum osmolarity

                                                                                                                              bull Hypovolemichypernatremic (burn fever)bull Hypovolemichyponatremic (vomiting diarrhea or fistula

                                                                                                                              drainage)bull Normovolemichyponatremic (decrease kidney reserve )bull Hypervolemichyponatremic (excessive water intakeTURP

                                                                                                                              DW5)

                                                                                                                              Hypernatremia

                                                                                                                              Serum Nagt145mEqL

                                                                                                                              - Hypernatremia

                                                                                                                              Loss of Free Water

                                                                                                                              Gain of sodium in excess of water

                                                                                                                              Hypernatremia

                                                                                                                              -Hypernatremia Hypo volemic

                                                                                                                              Hyper volemic

                                                                                                                              Normo volemic

                                                                                                                              Hypernatremia

                                                                                                                              Volume Status

                                                                                                                              Normal

                                                                                                                              Nonrenal water loss

                                                                                                                              Skin

                                                                                                                              Gastrointestinal

                                                                                                                              Renal water loss

                                                                                                                              Renal disease

                                                                                                                              Diuretics

                                                                                                                              Diabetes insipidus

                                                                                                                              High

                                                                                                                              Iatrogenic sodium administration

                                                                                                                              Mineralocorticoid excess

                                                                                                                              Aldosteronism

                                                                                                                              Cushingrsquos disease

                                                                                                                              Congenital adrenal

                                                                                                                              hyperplasia

                                                                                                                              Low

                                                                                                                              Nonrenal water loss

                                                                                                                              Skin

                                                                                                                              Gastrointestinal losses

                                                                                                                              Renal water losses

                                                                                                                              Renal (tubular) Diuretics

                                                                                                                              Osmotic diuretics

                                                                                                                              Diabetes insipidus

                                                                                                                              Adrenal failure

                                                                                                                              Asymptomatic

                                                                                                                              Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                                              Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                              Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                                              Body system hypernatremia

                                                                                                                              Treatment

                                                                                                                              Normal saline in hypovolemic patients

                                                                                                                              Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                                              saline or entral water)

                                                                                                                              Water deficit (L)= times TBW

                                                                                                                              The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                                              Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                                              Serum sodium-140

                                                                                                                              140

                                                                                                                              The rate of fluid administration

                                                                                                                              1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                                              2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                                              Hyponatremia Nalt135mEqL

                                                                                                                              Causes

                                                                                                                              1 Sodium depletion

                                                                                                                              2 Sodium dilution

                                                                                                                              bull Incidence = 45

                                                                                                                              bull After surgery=1

                                                                                                                              bull Mortality = 2 times normal

                                                                                                                              Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                                              volume deficit

                                                                                                                              Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                              Sign and symptoms

                                                                                                                              bull CNS symptom when Nalt123 meql

                                                                                                                              bull Cardiac symptom when Nalt100 meql

                                                                                                                              For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                              Body System Hyponatremia

                                                                                                                              central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                              reflexes seizures coma increased intracranial pressure

                                                                                                                              Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                              Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                              Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                              intracranial pressure

                                                                                                                              Tissue Lacrimation salivation

                                                                                                                              Renal Oliguria

                                                                                                                              Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                              Treatment

                                                                                                                              1=Depend on ECF

                                                                                                                              2=CNS sign

                                                                                                                              Treatment

                                                                                                                              1 Asymptomatic increase the sodium level by no more than

                                                                                                                              05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                              2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                              more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                              meqL or neurologic symptoms are improved

                                                                                                                              Rapid correction of hyponatremia

                                                                                                                              Pontine myelinolysis

                                                                                                                              Seizures weaknessparesis akinetic

                                                                                                                              movements unresponsiveness

                                                                                                                              Permanent brain damage

                                                                                                                              Death

                                                                                                                              Dose

                                                                                                                              Na deficit meq =(140- Na meql) TBW

                                                                                                                              باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                              شود اصالح آهسته سپس

                                                                                                                              Potassium abnormalities

                                                                                                                              bull The average dietary intake of potassium 50-100meqd

                                                                                                                              bull The average renal excretion of potassium 10-700 meqd

                                                                                                                              - 2 of the total body potassium in ECF (45meqL)

                                                                                                                              - Factors that influence serum potassium

                                                                                                                              1 Surgical stress

                                                                                                                              2 Injury

                                                                                                                              3 Acidosis

                                                                                                                              4 Tissue catabolism

                                                                                                                              Hyperkalemia

                                                                                                                              The normal range of serum potassium 35-5 meqL

                                                                                                                              Etiology of Hyperkalemia

                                                                                                                              Increased intake Potassium supplementation

                                                                                                                              Blood transfusions

                                                                                                                              Endogenous loaddestruction

                                                                                                                              hemolysis rhabdomyolysis

                                                                                                                              cruch injury gastrointestinal hemorrhage

                                                                                                                              Increased release Acidosis

                                                                                                                              Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                              Renal insufficiencyfailure

                                                                                                                              Clinical manifestation of hyperkalemia

                                                                                                                              System hyperkalemia

                                                                                                                              Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                              Neuromuscular weakness paralysis respiratory failure

                                                                                                                              Cardiovascular Arrhythmia arrest

                                                                                                                              ECG changes Peaked T waves (early change)

                                                                                                                              Flattened P wave

                                                                                                                              Prolonged PR interval (first-degree block)

                                                                                                                              Widened QRS complex

                                                                                                                              Sine wave formation

                                                                                                                              Ventricular fibrillation

                                                                                                                              Treatment

                                                                                                                              Treatment of symptomatic hyperkalemia

                                                                                                                              Potassium removal Kayexalate

                                                                                                                              Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                              Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                              Dialysis

                                                                                                                              Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                              Bicarbonate 1 vial intravenous

                                                                                                                              Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                              HypokalemiaEtiology

                                                                                                                              inadequate intake

                                                                                                                              Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                              total parenteral nutrition

                                                                                                                              Excessive potassium excretion

                                                                                                                              Hyperaldosteronism

                                                                                                                              Medications

                                                                                                                              Gastrointestinal losses

                                                                                                                              Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                              Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                              nasogastric output)

                                                                                                                              Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                              Potassium changes associated with alkalosis

                                                                                                                              Potassium decrease by 03 meqL for every 01

                                                                                                                              increase in PH above normal

                                                                                                                              Magnesium Depletion

                                                                                                                              (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                              Renal potassium wastage

                                                                                                                              Hypokalemia

                                                                                                                              Magnesium Depletion

                                                                                                                              (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                              Renal potassium wastage

                                                                                                                              Hypokalemia

                                                                                                                              Clinical Manifestation of Abnormalities in potassium

                                                                                                                              System hypokalemia

                                                                                                                              Gastrointestinal Ileus constipation

                                                                                                                              Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                              paralysis

                                                                                                                              Cardiovascular Arrest

                                                                                                                              ECG changes U-waves

                                                                                                                              T-wave flattening

                                                                                                                              ST-segment changes

                                                                                                                              Arrhythmias

                                                                                                                              Treatment

                                                                                                                              Potassium

                                                                                                                              Serum potassium level lt40 mEqL

                                                                                                                              Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                              times 1 doses

                                                                                                                              Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                              Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                              Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                              asymptomatic replace as per above protocol

                                                                                                                              Electrolyte Replacement Therapy Protocol

                                                                                                                              bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                              bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                              Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                              ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                              عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                              صاف 2 عضالت انقباض

                                                                                                                              هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                              انعقاد 4

                                                                                                                              یونیزه Calt45 meql هيپوكلسمي

                                                                                                                              عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                              ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                              میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                              ( شود می پیوند شده

                                                                                                                              هیپوکلسمی عالئم

                                                                                                                              رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                              سایرعالئم

                                                                                                                              قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                              درمان

                                                                                                                              ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                              Cagt55meql هيپركلسمي

                                                                                                                              هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                              عالئم

                                                                                                                              bullGI

                                                                                                                              bullCardiovascular bullRenal (polyuria)

                                                                                                                              bullCNS

                                                                                                                              قلبی عالئم

                                                                                                                              bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                              QRS شدن )Q-Tوكوتاه

                                                                                                                              درمان

                                                                                                                              ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                              الزیکس2

                                                                                                                              تونین 3 کلسی

                                                                                                                              کورتون4

                                                                                                                              دیالیز5

                                                                                                                              Magnesium Abnormalities

                                                                                                                              Normal dietary intake 20meq (240mg)

                                                                                                                              Excretion in both the feces and urine

                                                                                                                              Normal serum level 19-25 mgdL

                                                                                                                              منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                              تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                              bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                              Hypermagnesemia

                                                                                                                              Etiology

                                                                                                                              1 Impaired renal function

                                                                                                                              2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                              Clinical manifestation hypermanesemia

                                                                                                                              System hypermanesemia

                                                                                                                              Gastrointestinal Nauseavomiting

                                                                                                                              Neuromuscular weakness lethargy Decreased

                                                                                                                              reflexes

                                                                                                                              Cardiovascular Hypotension arrest

                                                                                                                              ECG changes Increased PR interval

                                                                                                                              Widened QRS complex

                                                                                                                              Elevated T waves

                                                                                                                              Treatment

                                                                                                                              1 Withhold exogenous sources of magnesium

                                                                                                                              2 Correct volume deficit

                                                                                                                              3 Correct acidosis if present

                                                                                                                              4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                              5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                              عالئم

                                                                                                                              bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                              meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                              meqL

                                                                                                                              Hypomagnesemia

                                                                                                                              Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                              homeostasis

                                                                                                                              Etiology

                                                                                                                              1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                              inadequate supplementation of magnesium)

                                                                                                                              2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                              3 GI losses (diarrhea)

                                                                                                                              4 Malabsorption

                                                                                                                              5 Acute pancreatitis

                                                                                                                              6 Diabetic ketoacidosis

                                                                                                                              7 Primary aldosteronism

                                                                                                                              Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                              1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                              2 Delirium and seizures in severe deficiency

                                                                                                                              3 ECG changes Prolonged QT and PR interval

                                                                                                                              ST-segment depression

                                                                                                                              Flattening or inversion of P waves

                                                                                                                              Torsades de pointes

                                                                                                                              Arrhythmia

                                                                                                                              Treatment

                                                                                                                              1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                              2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                              Message for Today

                                                                                                                              ICF

                                                                                                                              Interstitial

                                                                                                                              Pla

                                                                                                                              sma

                                                                                                                              5 Dex

                                                                                                                              bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                              • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                              • Slide 2
                                                                                                                              • Slide 3
                                                                                                                              • Slide 4
                                                                                                                              • Total Body Water
                                                                                                                              • Body Fluid Compartments
                                                                                                                              • Total body water (TBW)
                                                                                                                              • Body compartment fluid
                                                                                                                              • Example men with 70kg
                                                                                                                              • Fluid compartments
                                                                                                                              • Slide 11
                                                                                                                              • Slide 12
                                                                                                                              • Slide 13
                                                                                                                              • Slide 14
                                                                                                                              • Slide 15
                                                                                                                              • Colloid osmotic pressure
                                                                                                                              • Slide 17
                                                                                                                              • Slide 18
                                                                                                                              • Slide 19
                                                                                                                              • Cell Membrane
                                                                                                                              • Slide 21
                                                                                                                              • Slide 22
                                                                                                                              • Slide 23
                                                                                                                              • Slide 24
                                                                                                                              • Slide 25
                                                                                                                              • Composition of Fluid Compartments
                                                                                                                              • Composition of Body Fluids
                                                                                                                              • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                              • Reasons for fluid therapy
                                                                                                                              • ارزیابی حجم مایع داخل عروقی
                                                                                                                              • محلولهای وریدی
                                                                                                                              • Fluids
                                                                                                                              • Slide 33
                                                                                                                              • Slide 34
                                                                                                                              • Slide 35
                                                                                                                              • Crystalloids
                                                                                                                              • Colloid Solutions
                                                                                                                              • رینگر لاکتات
                                                                                                                              • 09Nacl
                                                                                                                              • Postoperative (maintenance)
                                                                                                                              • Slide 41
                                                                                                                              • Preexisting fluid deficits
                                                                                                                              • Maintenance requirements
                                                                                                                              • Surgical fluid losses
                                                                                                                              • Third space loss
                                                                                                                              • Crystalloid solution
                                                                                                                              • Colloids
                                                                                                                              • Complications
                                                                                                                              • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                              • Colloid versus crystalloid solutions
                                                                                                                              • Transfusion consideration
                                                                                                                              • اختلال در حجم مایعات بدن
                                                                                                                              • Fluid volume deficit (FVD)
                                                                                                                              • DEHYDRATION
                                                                                                                              • علل کاهش حجم خارج سلولی
                                                                                                                              • Signs of Hypovolemia
                                                                                                                              • Clinical Diagnosis of Hypovolemia
                                                                                                                              • Signs of Hypervolemia
                                                                                                                              • Management of Hypervolemia
                                                                                                                              • Fluid Management
                                                                                                                              • Electrolyte physiology
                                                                                                                              • Sodium physiology
                                                                                                                              • Osmotic Pressure
                                                                                                                              • Concentration
                                                                                                                              • Hypernatremia
                                                                                                                              • - Hypernatremia
                                                                                                                              • Slide 67
                                                                                                                              • Slide 68
                                                                                                                              • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                              • Treatment
                                                                                                                              • Water deficit (L)= times TBW
                                                                                                                              • The rate of fluid administration
                                                                                                                              • Hyponatremia Nalt135mEqL
                                                                                                                              • Slide 74
                                                                                                                              • Sodium depletion
                                                                                                                              • Sodium dilution
                                                                                                                              • Sign and symptoms
                                                                                                                              • Slide 78
                                                                                                                              • Treatment
                                                                                                                              • Slide 80
                                                                                                                              • Slide 81
                                                                                                                              • Dose
                                                                                                                              • Potassium abnormalities
                                                                                                                              • Hyperkalemia
                                                                                                                              • Clinical manifestation of hyperkalemia
                                                                                                                              • Slide 86
                                                                                                                              • Slide 87
                                                                                                                              • Hypokalemia
                                                                                                                              • Potassium changes associated with alkalosis
                                                                                                                              • Slide 90
                                                                                                                              • Clinical Manifestation of Abnormalities in potassium
                                                                                                                              • Slide 92
                                                                                                                              • Calcium
                                                                                                                              • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                              • علائم هیپوکلسمی
                                                                                                                              • Slide 96
                                                                                                                              • Slide 97
                                                                                                                              • Slide 98
                                                                                                                              • Slide 99
                                                                                                                              • سایرعلائم
                                                                                                                              • درمان
                                                                                                                              • هيپركلسمي Cagt55meql
                                                                                                                              • علائم
                                                                                                                              • علائم قلبی
                                                                                                                              • Slide 105
                                                                                                                              • Magnesium Abnormalities
                                                                                                                              • منیزیوم
                                                                                                                              • Hypermagnesemia
                                                                                                                              • Clinical manifestation hypermanesemia
                                                                                                                              • Slide 110
                                                                                                                              • Slide 111
                                                                                                                              • Hypomagnesemia
                                                                                                                              • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                              • Slide 114
                                                                                                                              • Message for Today
                                                                                                                              • Slide 116

                                                                                                                                Hypernatremia

                                                                                                                                Serum Nagt145mEqL

                                                                                                                                - Hypernatremia

                                                                                                                                Loss of Free Water

                                                                                                                                Gain of sodium in excess of water

                                                                                                                                Hypernatremia

                                                                                                                                -Hypernatremia Hypo volemic

                                                                                                                                Hyper volemic

                                                                                                                                Normo volemic

                                                                                                                                Hypernatremia

                                                                                                                                Volume Status

                                                                                                                                Normal

                                                                                                                                Nonrenal water loss

                                                                                                                                Skin

                                                                                                                                Gastrointestinal

                                                                                                                                Renal water loss

                                                                                                                                Renal disease

                                                                                                                                Diuretics

                                                                                                                                Diabetes insipidus

                                                                                                                                High

                                                                                                                                Iatrogenic sodium administration

                                                                                                                                Mineralocorticoid excess

                                                                                                                                Aldosteronism

                                                                                                                                Cushingrsquos disease

                                                                                                                                Congenital adrenal

                                                                                                                                hyperplasia

                                                                                                                                Low

                                                                                                                                Nonrenal water loss

                                                                                                                                Skin

                                                                                                                                Gastrointestinal losses

                                                                                                                                Renal water losses

                                                                                                                                Renal (tubular) Diuretics

                                                                                                                                Osmotic diuretics

                                                                                                                                Diabetes insipidus

                                                                                                                                Adrenal failure

                                                                                                                                Asymptomatic

                                                                                                                                Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                                                Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                                Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                                                Body system hypernatremia

                                                                                                                                Treatment

                                                                                                                                Normal saline in hypovolemic patients

                                                                                                                                Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                                                saline or entral water)

                                                                                                                                Water deficit (L)= times TBW

                                                                                                                                The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                                                Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                                                Serum sodium-140

                                                                                                                                140

                                                                                                                                The rate of fluid administration

                                                                                                                                1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                                                2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                                                Hyponatremia Nalt135mEqL

                                                                                                                                Causes

                                                                                                                                1 Sodium depletion

                                                                                                                                2 Sodium dilution

                                                                                                                                bull Incidence = 45

                                                                                                                                bull After surgery=1

                                                                                                                                bull Mortality = 2 times normal

                                                                                                                                Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                                                volume deficit

                                                                                                                                Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                                Sign and symptoms

                                                                                                                                bull CNS symptom when Nalt123 meql

                                                                                                                                bull Cardiac symptom when Nalt100 meql

                                                                                                                                For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                                Body System Hyponatremia

                                                                                                                                central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                                reflexes seizures coma increased intracranial pressure

                                                                                                                                Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                                Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                                Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                                intracranial pressure

                                                                                                                                Tissue Lacrimation salivation

                                                                                                                                Renal Oliguria

                                                                                                                                Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                                Treatment

                                                                                                                                1=Depend on ECF

                                                                                                                                2=CNS sign

                                                                                                                                Treatment

                                                                                                                                1 Asymptomatic increase the sodium level by no more than

                                                                                                                                05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                                2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                                more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                                meqL or neurologic symptoms are improved

                                                                                                                                Rapid correction of hyponatremia

                                                                                                                                Pontine myelinolysis

                                                                                                                                Seizures weaknessparesis akinetic

                                                                                                                                movements unresponsiveness

                                                                                                                                Permanent brain damage

                                                                                                                                Death

                                                                                                                                Dose

                                                                                                                                Na deficit meq =(140- Na meql) TBW

                                                                                                                                باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                                شود اصالح آهسته سپس

                                                                                                                                Potassium abnormalities

                                                                                                                                bull The average dietary intake of potassium 50-100meqd

                                                                                                                                bull The average renal excretion of potassium 10-700 meqd

                                                                                                                                - 2 of the total body potassium in ECF (45meqL)

                                                                                                                                - Factors that influence serum potassium

                                                                                                                                1 Surgical stress

                                                                                                                                2 Injury

                                                                                                                                3 Acidosis

                                                                                                                                4 Tissue catabolism

                                                                                                                                Hyperkalemia

                                                                                                                                The normal range of serum potassium 35-5 meqL

                                                                                                                                Etiology of Hyperkalemia

                                                                                                                                Increased intake Potassium supplementation

                                                                                                                                Blood transfusions

                                                                                                                                Endogenous loaddestruction

                                                                                                                                hemolysis rhabdomyolysis

                                                                                                                                cruch injury gastrointestinal hemorrhage

                                                                                                                                Increased release Acidosis

                                                                                                                                Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                Renal insufficiencyfailure

                                                                                                                                Clinical manifestation of hyperkalemia

                                                                                                                                System hyperkalemia

                                                                                                                                Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                Neuromuscular weakness paralysis respiratory failure

                                                                                                                                Cardiovascular Arrhythmia arrest

                                                                                                                                ECG changes Peaked T waves (early change)

                                                                                                                                Flattened P wave

                                                                                                                                Prolonged PR interval (first-degree block)

                                                                                                                                Widened QRS complex

                                                                                                                                Sine wave formation

                                                                                                                                Ventricular fibrillation

                                                                                                                                Treatment

                                                                                                                                Treatment of symptomatic hyperkalemia

                                                                                                                                Potassium removal Kayexalate

                                                                                                                                Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                Dialysis

                                                                                                                                Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                Bicarbonate 1 vial intravenous

                                                                                                                                Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                HypokalemiaEtiology

                                                                                                                                inadequate intake

                                                                                                                                Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                total parenteral nutrition

                                                                                                                                Excessive potassium excretion

                                                                                                                                Hyperaldosteronism

                                                                                                                                Medications

                                                                                                                                Gastrointestinal losses

                                                                                                                                Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                nasogastric output)

                                                                                                                                Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                Potassium changes associated with alkalosis

                                                                                                                                Potassium decrease by 03 meqL for every 01

                                                                                                                                increase in PH above normal

                                                                                                                                Magnesium Depletion

                                                                                                                                (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                Renal potassium wastage

                                                                                                                                Hypokalemia

                                                                                                                                Magnesium Depletion

                                                                                                                                (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                Renal potassium wastage

                                                                                                                                Hypokalemia

                                                                                                                                Clinical Manifestation of Abnormalities in potassium

                                                                                                                                System hypokalemia

                                                                                                                                Gastrointestinal Ileus constipation

                                                                                                                                Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                paralysis

                                                                                                                                Cardiovascular Arrest

                                                                                                                                ECG changes U-waves

                                                                                                                                T-wave flattening

                                                                                                                                ST-segment changes

                                                                                                                                Arrhythmias

                                                                                                                                Treatment

                                                                                                                                Potassium

                                                                                                                                Serum potassium level lt40 mEqL

                                                                                                                                Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                times 1 doses

                                                                                                                                Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                asymptomatic replace as per above protocol

                                                                                                                                Electrolyte Replacement Therapy Protocol

                                                                                                                                bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                صاف 2 عضالت انقباض

                                                                                                                                هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                انعقاد 4

                                                                                                                                یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                ( شود می پیوند شده

                                                                                                                                هیپوکلسمی عالئم

                                                                                                                                رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                سایرعالئم

                                                                                                                                قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                درمان

                                                                                                                                ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                Cagt55meql هيپركلسمي

                                                                                                                                هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                عالئم

                                                                                                                                bullGI

                                                                                                                                bullCardiovascular bullRenal (polyuria)

                                                                                                                                bullCNS

                                                                                                                                قلبی عالئم

                                                                                                                                bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                QRS شدن )Q-Tوكوتاه

                                                                                                                                درمان

                                                                                                                                ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                الزیکس2

                                                                                                                                تونین 3 کلسی

                                                                                                                                کورتون4

                                                                                                                                دیالیز5

                                                                                                                                Magnesium Abnormalities

                                                                                                                                Normal dietary intake 20meq (240mg)

                                                                                                                                Excretion in both the feces and urine

                                                                                                                                Normal serum level 19-25 mgdL

                                                                                                                                منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                Hypermagnesemia

                                                                                                                                Etiology

                                                                                                                                1 Impaired renal function

                                                                                                                                2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                Clinical manifestation hypermanesemia

                                                                                                                                System hypermanesemia

                                                                                                                                Gastrointestinal Nauseavomiting

                                                                                                                                Neuromuscular weakness lethargy Decreased

                                                                                                                                reflexes

                                                                                                                                Cardiovascular Hypotension arrest

                                                                                                                                ECG changes Increased PR interval

                                                                                                                                Widened QRS complex

                                                                                                                                Elevated T waves

                                                                                                                                Treatment

                                                                                                                                1 Withhold exogenous sources of magnesium

                                                                                                                                2 Correct volume deficit

                                                                                                                                3 Correct acidosis if present

                                                                                                                                4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                عالئم

                                                                                                                                bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                meqL

                                                                                                                                Hypomagnesemia

                                                                                                                                Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                homeostasis

                                                                                                                                Etiology

                                                                                                                                1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                inadequate supplementation of magnesium)

                                                                                                                                2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                3 GI losses (diarrhea)

                                                                                                                                4 Malabsorption

                                                                                                                                5 Acute pancreatitis

                                                                                                                                6 Diabetic ketoacidosis

                                                                                                                                7 Primary aldosteronism

                                                                                                                                Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                2 Delirium and seizures in severe deficiency

                                                                                                                                3 ECG changes Prolonged QT and PR interval

                                                                                                                                ST-segment depression

                                                                                                                                Flattening or inversion of P waves

                                                                                                                                Torsades de pointes

                                                                                                                                Arrhythmia

                                                                                                                                Treatment

                                                                                                                                1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                Message for Today

                                                                                                                                ICF

                                                                                                                                Interstitial

                                                                                                                                Pla

                                                                                                                                sma

                                                                                                                                5 Dex

                                                                                                                                bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                • Slide 2
                                                                                                                                • Slide 3
                                                                                                                                • Slide 4
                                                                                                                                • Total Body Water
                                                                                                                                • Body Fluid Compartments
                                                                                                                                • Total body water (TBW)
                                                                                                                                • Body compartment fluid
                                                                                                                                • Example men with 70kg
                                                                                                                                • Fluid compartments
                                                                                                                                • Slide 11
                                                                                                                                • Slide 12
                                                                                                                                • Slide 13
                                                                                                                                • Slide 14
                                                                                                                                • Slide 15
                                                                                                                                • Colloid osmotic pressure
                                                                                                                                • Slide 17
                                                                                                                                • Slide 18
                                                                                                                                • Slide 19
                                                                                                                                • Cell Membrane
                                                                                                                                • Slide 21
                                                                                                                                • Slide 22
                                                                                                                                • Slide 23
                                                                                                                                • Slide 24
                                                                                                                                • Slide 25
                                                                                                                                • Composition of Fluid Compartments
                                                                                                                                • Composition of Body Fluids
                                                                                                                                • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                • Reasons for fluid therapy
                                                                                                                                • ارزیابی حجم مایع داخل عروقی
                                                                                                                                • محلولهای وریدی
                                                                                                                                • Fluids
                                                                                                                                • Slide 33
                                                                                                                                • Slide 34
                                                                                                                                • Slide 35
                                                                                                                                • Crystalloids
                                                                                                                                • Colloid Solutions
                                                                                                                                • رینگر لاکتات
                                                                                                                                • 09Nacl
                                                                                                                                • Postoperative (maintenance)
                                                                                                                                • Slide 41
                                                                                                                                • Preexisting fluid deficits
                                                                                                                                • Maintenance requirements
                                                                                                                                • Surgical fluid losses
                                                                                                                                • Third space loss
                                                                                                                                • Crystalloid solution
                                                                                                                                • Colloids
                                                                                                                                • Complications
                                                                                                                                • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                • Colloid versus crystalloid solutions
                                                                                                                                • Transfusion consideration
                                                                                                                                • اختلال در حجم مایعات بدن
                                                                                                                                • Fluid volume deficit (FVD)
                                                                                                                                • DEHYDRATION
                                                                                                                                • علل کاهش حجم خارج سلولی
                                                                                                                                • Signs of Hypovolemia
                                                                                                                                • Clinical Diagnosis of Hypovolemia
                                                                                                                                • Signs of Hypervolemia
                                                                                                                                • Management of Hypervolemia
                                                                                                                                • Fluid Management
                                                                                                                                • Electrolyte physiology
                                                                                                                                • Sodium physiology
                                                                                                                                • Osmotic Pressure
                                                                                                                                • Concentration
                                                                                                                                • Hypernatremia
                                                                                                                                • - Hypernatremia
                                                                                                                                • Slide 67
                                                                                                                                • Slide 68
                                                                                                                                • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                • Treatment
                                                                                                                                • Water deficit (L)= times TBW
                                                                                                                                • The rate of fluid administration
                                                                                                                                • Hyponatremia Nalt135mEqL
                                                                                                                                • Slide 74
                                                                                                                                • Sodium depletion
                                                                                                                                • Sodium dilution
                                                                                                                                • Sign and symptoms
                                                                                                                                • Slide 78
                                                                                                                                • Treatment
                                                                                                                                • Slide 80
                                                                                                                                • Slide 81
                                                                                                                                • Dose
                                                                                                                                • Potassium abnormalities
                                                                                                                                • Hyperkalemia
                                                                                                                                • Clinical manifestation of hyperkalemia
                                                                                                                                • Slide 86
                                                                                                                                • Slide 87
                                                                                                                                • Hypokalemia
                                                                                                                                • Potassium changes associated with alkalosis
                                                                                                                                • Slide 90
                                                                                                                                • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                • Slide 92
                                                                                                                                • Calcium
                                                                                                                                • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                • علائم هیپوکلسمی
                                                                                                                                • Slide 96
                                                                                                                                • Slide 97
                                                                                                                                • Slide 98
                                                                                                                                • Slide 99
                                                                                                                                • سایرعلائم
                                                                                                                                • درمان
                                                                                                                                • هيپركلسمي Cagt55meql
                                                                                                                                • علائم
                                                                                                                                • علائم قلبی
                                                                                                                                • Slide 105
                                                                                                                                • Magnesium Abnormalities
                                                                                                                                • منیزیوم
                                                                                                                                • Hypermagnesemia
                                                                                                                                • Clinical manifestation hypermanesemia
                                                                                                                                • Slide 110
                                                                                                                                • Slide 111
                                                                                                                                • Hypomagnesemia
                                                                                                                                • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                • Slide 114
                                                                                                                                • Message for Today
                                                                                                                                • Slide 116

                                                                                                                                  - Hypernatremia

                                                                                                                                  Loss of Free Water

                                                                                                                                  Gain of sodium in excess of water

                                                                                                                                  Hypernatremia

                                                                                                                                  -Hypernatremia Hypo volemic

                                                                                                                                  Hyper volemic

                                                                                                                                  Normo volemic

                                                                                                                                  Hypernatremia

                                                                                                                                  Volume Status

                                                                                                                                  Normal

                                                                                                                                  Nonrenal water loss

                                                                                                                                  Skin

                                                                                                                                  Gastrointestinal

                                                                                                                                  Renal water loss

                                                                                                                                  Renal disease

                                                                                                                                  Diuretics

                                                                                                                                  Diabetes insipidus

                                                                                                                                  High

                                                                                                                                  Iatrogenic sodium administration

                                                                                                                                  Mineralocorticoid excess

                                                                                                                                  Aldosteronism

                                                                                                                                  Cushingrsquos disease

                                                                                                                                  Congenital adrenal

                                                                                                                                  hyperplasia

                                                                                                                                  Low

                                                                                                                                  Nonrenal water loss

                                                                                                                                  Skin

                                                                                                                                  Gastrointestinal losses

                                                                                                                                  Renal water losses

                                                                                                                                  Renal (tubular) Diuretics

                                                                                                                                  Osmotic diuretics

                                                                                                                                  Diabetes insipidus

                                                                                                                                  Adrenal failure

                                                                                                                                  Asymptomatic

                                                                                                                                  Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                                                  Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                                  Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                                                  Body system hypernatremia

                                                                                                                                  Treatment

                                                                                                                                  Normal saline in hypovolemic patients

                                                                                                                                  Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                                                  saline or entral water)

                                                                                                                                  Water deficit (L)= times TBW

                                                                                                                                  The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                                                  Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                                                  Serum sodium-140

                                                                                                                                  140

                                                                                                                                  The rate of fluid administration

                                                                                                                                  1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                                                  2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                                                  Hyponatremia Nalt135mEqL

                                                                                                                                  Causes

                                                                                                                                  1 Sodium depletion

                                                                                                                                  2 Sodium dilution

                                                                                                                                  bull Incidence = 45

                                                                                                                                  bull After surgery=1

                                                                                                                                  bull Mortality = 2 times normal

                                                                                                                                  Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                                                  volume deficit

                                                                                                                                  Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                                  Sign and symptoms

                                                                                                                                  bull CNS symptom when Nalt123 meql

                                                                                                                                  bull Cardiac symptom when Nalt100 meql

                                                                                                                                  For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                                  Body System Hyponatremia

                                                                                                                                  central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                                  reflexes seizures coma increased intracranial pressure

                                                                                                                                  Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                                  Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                                  Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                                  intracranial pressure

                                                                                                                                  Tissue Lacrimation salivation

                                                                                                                                  Renal Oliguria

                                                                                                                                  Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                                  Treatment

                                                                                                                                  1=Depend on ECF

                                                                                                                                  2=CNS sign

                                                                                                                                  Treatment

                                                                                                                                  1 Asymptomatic increase the sodium level by no more than

                                                                                                                                  05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                                  2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                                  more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                                  meqL or neurologic symptoms are improved

                                                                                                                                  Rapid correction of hyponatremia

                                                                                                                                  Pontine myelinolysis

                                                                                                                                  Seizures weaknessparesis akinetic

                                                                                                                                  movements unresponsiveness

                                                                                                                                  Permanent brain damage

                                                                                                                                  Death

                                                                                                                                  Dose

                                                                                                                                  Na deficit meq =(140- Na meql) TBW

                                                                                                                                  باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                                  شود اصالح آهسته سپس

                                                                                                                                  Potassium abnormalities

                                                                                                                                  bull The average dietary intake of potassium 50-100meqd

                                                                                                                                  bull The average renal excretion of potassium 10-700 meqd

                                                                                                                                  - 2 of the total body potassium in ECF (45meqL)

                                                                                                                                  - Factors that influence serum potassium

                                                                                                                                  1 Surgical stress

                                                                                                                                  2 Injury

                                                                                                                                  3 Acidosis

                                                                                                                                  4 Tissue catabolism

                                                                                                                                  Hyperkalemia

                                                                                                                                  The normal range of serum potassium 35-5 meqL

                                                                                                                                  Etiology of Hyperkalemia

                                                                                                                                  Increased intake Potassium supplementation

                                                                                                                                  Blood transfusions

                                                                                                                                  Endogenous loaddestruction

                                                                                                                                  hemolysis rhabdomyolysis

                                                                                                                                  cruch injury gastrointestinal hemorrhage

                                                                                                                                  Increased release Acidosis

                                                                                                                                  Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                  Renal insufficiencyfailure

                                                                                                                                  Clinical manifestation of hyperkalemia

                                                                                                                                  System hyperkalemia

                                                                                                                                  Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                  Neuromuscular weakness paralysis respiratory failure

                                                                                                                                  Cardiovascular Arrhythmia arrest

                                                                                                                                  ECG changes Peaked T waves (early change)

                                                                                                                                  Flattened P wave

                                                                                                                                  Prolonged PR interval (first-degree block)

                                                                                                                                  Widened QRS complex

                                                                                                                                  Sine wave formation

                                                                                                                                  Ventricular fibrillation

                                                                                                                                  Treatment

                                                                                                                                  Treatment of symptomatic hyperkalemia

                                                                                                                                  Potassium removal Kayexalate

                                                                                                                                  Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                  Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                  Dialysis

                                                                                                                                  Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                  Bicarbonate 1 vial intravenous

                                                                                                                                  Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                  HypokalemiaEtiology

                                                                                                                                  inadequate intake

                                                                                                                                  Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                  total parenteral nutrition

                                                                                                                                  Excessive potassium excretion

                                                                                                                                  Hyperaldosteronism

                                                                                                                                  Medications

                                                                                                                                  Gastrointestinal losses

                                                                                                                                  Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                  Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                  nasogastric output)

                                                                                                                                  Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                  Potassium changes associated with alkalosis

                                                                                                                                  Potassium decrease by 03 meqL for every 01

                                                                                                                                  increase in PH above normal

                                                                                                                                  Magnesium Depletion

                                                                                                                                  (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                  Renal potassium wastage

                                                                                                                                  Hypokalemia

                                                                                                                                  Magnesium Depletion

                                                                                                                                  (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                  Renal potassium wastage

                                                                                                                                  Hypokalemia

                                                                                                                                  Clinical Manifestation of Abnormalities in potassium

                                                                                                                                  System hypokalemia

                                                                                                                                  Gastrointestinal Ileus constipation

                                                                                                                                  Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                  paralysis

                                                                                                                                  Cardiovascular Arrest

                                                                                                                                  ECG changes U-waves

                                                                                                                                  T-wave flattening

                                                                                                                                  ST-segment changes

                                                                                                                                  Arrhythmias

                                                                                                                                  Treatment

                                                                                                                                  Potassium

                                                                                                                                  Serum potassium level lt40 mEqL

                                                                                                                                  Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                  times 1 doses

                                                                                                                                  Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                  Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                  Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                  asymptomatic replace as per above protocol

                                                                                                                                  Electrolyte Replacement Therapy Protocol

                                                                                                                                  bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                  bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                  Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                  ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                  عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                  صاف 2 عضالت انقباض

                                                                                                                                  هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                  انعقاد 4

                                                                                                                                  یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                  عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                  ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                  میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                  ( شود می پیوند شده

                                                                                                                                  هیپوکلسمی عالئم

                                                                                                                                  رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                  سایرعالئم

                                                                                                                                  قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                  درمان

                                                                                                                                  ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                  Cagt55meql هيپركلسمي

                                                                                                                                  هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                  عالئم

                                                                                                                                  bullGI

                                                                                                                                  bullCardiovascular bullRenal (polyuria)

                                                                                                                                  bullCNS

                                                                                                                                  قلبی عالئم

                                                                                                                                  bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                  QRS شدن )Q-Tوكوتاه

                                                                                                                                  درمان

                                                                                                                                  ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                  الزیکس2

                                                                                                                                  تونین 3 کلسی

                                                                                                                                  کورتون4

                                                                                                                                  دیالیز5

                                                                                                                                  Magnesium Abnormalities

                                                                                                                                  Normal dietary intake 20meq (240mg)

                                                                                                                                  Excretion in both the feces and urine

                                                                                                                                  Normal serum level 19-25 mgdL

                                                                                                                                  منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                  تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                  bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                  Hypermagnesemia

                                                                                                                                  Etiology

                                                                                                                                  1 Impaired renal function

                                                                                                                                  2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                  Clinical manifestation hypermanesemia

                                                                                                                                  System hypermanesemia

                                                                                                                                  Gastrointestinal Nauseavomiting

                                                                                                                                  Neuromuscular weakness lethargy Decreased

                                                                                                                                  reflexes

                                                                                                                                  Cardiovascular Hypotension arrest

                                                                                                                                  ECG changes Increased PR interval

                                                                                                                                  Widened QRS complex

                                                                                                                                  Elevated T waves

                                                                                                                                  Treatment

                                                                                                                                  1 Withhold exogenous sources of magnesium

                                                                                                                                  2 Correct volume deficit

                                                                                                                                  3 Correct acidosis if present

                                                                                                                                  4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                  5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                  عالئم

                                                                                                                                  bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                  meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                  meqL

                                                                                                                                  Hypomagnesemia

                                                                                                                                  Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                  homeostasis

                                                                                                                                  Etiology

                                                                                                                                  1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                  inadequate supplementation of magnesium)

                                                                                                                                  2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                  3 GI losses (diarrhea)

                                                                                                                                  4 Malabsorption

                                                                                                                                  5 Acute pancreatitis

                                                                                                                                  6 Diabetic ketoacidosis

                                                                                                                                  7 Primary aldosteronism

                                                                                                                                  Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                  1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                  2 Delirium and seizures in severe deficiency

                                                                                                                                  3 ECG changes Prolonged QT and PR interval

                                                                                                                                  ST-segment depression

                                                                                                                                  Flattening or inversion of P waves

                                                                                                                                  Torsades de pointes

                                                                                                                                  Arrhythmia

                                                                                                                                  Treatment

                                                                                                                                  1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                  2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                  Message for Today

                                                                                                                                  ICF

                                                                                                                                  Interstitial

                                                                                                                                  Pla

                                                                                                                                  sma

                                                                                                                                  5 Dex

                                                                                                                                  bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                  • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                  • Slide 2
                                                                                                                                  • Slide 3
                                                                                                                                  • Slide 4
                                                                                                                                  • Total Body Water
                                                                                                                                  • Body Fluid Compartments
                                                                                                                                  • Total body water (TBW)
                                                                                                                                  • Body compartment fluid
                                                                                                                                  • Example men with 70kg
                                                                                                                                  • Fluid compartments
                                                                                                                                  • Slide 11
                                                                                                                                  • Slide 12
                                                                                                                                  • Slide 13
                                                                                                                                  • Slide 14
                                                                                                                                  • Slide 15
                                                                                                                                  • Colloid osmotic pressure
                                                                                                                                  • Slide 17
                                                                                                                                  • Slide 18
                                                                                                                                  • Slide 19
                                                                                                                                  • Cell Membrane
                                                                                                                                  • Slide 21
                                                                                                                                  • Slide 22
                                                                                                                                  • Slide 23
                                                                                                                                  • Slide 24
                                                                                                                                  • Slide 25
                                                                                                                                  • Composition of Fluid Compartments
                                                                                                                                  • Composition of Body Fluids
                                                                                                                                  • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                  • Reasons for fluid therapy
                                                                                                                                  • ارزیابی حجم مایع داخل عروقی
                                                                                                                                  • محلولهای وریدی
                                                                                                                                  • Fluids
                                                                                                                                  • Slide 33
                                                                                                                                  • Slide 34
                                                                                                                                  • Slide 35
                                                                                                                                  • Crystalloids
                                                                                                                                  • Colloid Solutions
                                                                                                                                  • رینگر لاکتات
                                                                                                                                  • 09Nacl
                                                                                                                                  • Postoperative (maintenance)
                                                                                                                                  • Slide 41
                                                                                                                                  • Preexisting fluid deficits
                                                                                                                                  • Maintenance requirements
                                                                                                                                  • Surgical fluid losses
                                                                                                                                  • Third space loss
                                                                                                                                  • Crystalloid solution
                                                                                                                                  • Colloids
                                                                                                                                  • Complications
                                                                                                                                  • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                  • Colloid versus crystalloid solutions
                                                                                                                                  • Transfusion consideration
                                                                                                                                  • اختلال در حجم مایعات بدن
                                                                                                                                  • Fluid volume deficit (FVD)
                                                                                                                                  • DEHYDRATION
                                                                                                                                  • علل کاهش حجم خارج سلولی
                                                                                                                                  • Signs of Hypovolemia
                                                                                                                                  • Clinical Diagnosis of Hypovolemia
                                                                                                                                  • Signs of Hypervolemia
                                                                                                                                  • Management of Hypervolemia
                                                                                                                                  • Fluid Management
                                                                                                                                  • Electrolyte physiology
                                                                                                                                  • Sodium physiology
                                                                                                                                  • Osmotic Pressure
                                                                                                                                  • Concentration
                                                                                                                                  • Hypernatremia
                                                                                                                                  • - Hypernatremia
                                                                                                                                  • Slide 67
                                                                                                                                  • Slide 68
                                                                                                                                  • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                  • Treatment
                                                                                                                                  • Water deficit (L)= times TBW
                                                                                                                                  • The rate of fluid administration
                                                                                                                                  • Hyponatremia Nalt135mEqL
                                                                                                                                  • Slide 74
                                                                                                                                  • Sodium depletion
                                                                                                                                  • Sodium dilution
                                                                                                                                  • Sign and symptoms
                                                                                                                                  • Slide 78
                                                                                                                                  • Treatment
                                                                                                                                  • Slide 80
                                                                                                                                  • Slide 81
                                                                                                                                  • Dose
                                                                                                                                  • Potassium abnormalities
                                                                                                                                  • Hyperkalemia
                                                                                                                                  • Clinical manifestation of hyperkalemia
                                                                                                                                  • Slide 86
                                                                                                                                  • Slide 87
                                                                                                                                  • Hypokalemia
                                                                                                                                  • Potassium changes associated with alkalosis
                                                                                                                                  • Slide 90
                                                                                                                                  • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                  • Slide 92
                                                                                                                                  • Calcium
                                                                                                                                  • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                  • علائم هیپوکلسمی
                                                                                                                                  • Slide 96
                                                                                                                                  • Slide 97
                                                                                                                                  • Slide 98
                                                                                                                                  • Slide 99
                                                                                                                                  • سایرعلائم
                                                                                                                                  • درمان
                                                                                                                                  • هيپركلسمي Cagt55meql
                                                                                                                                  • علائم
                                                                                                                                  • علائم قلبی
                                                                                                                                  • Slide 105
                                                                                                                                  • Magnesium Abnormalities
                                                                                                                                  • منیزیوم
                                                                                                                                  • Hypermagnesemia
                                                                                                                                  • Clinical manifestation hypermanesemia
                                                                                                                                  • Slide 110
                                                                                                                                  • Slide 111
                                                                                                                                  • Hypomagnesemia
                                                                                                                                  • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                  • Slide 114
                                                                                                                                  • Message for Today
                                                                                                                                  • Slide 116

                                                                                                                                    Hypernatremia

                                                                                                                                    Volume Status

                                                                                                                                    Normal

                                                                                                                                    Nonrenal water loss

                                                                                                                                    Skin

                                                                                                                                    Gastrointestinal

                                                                                                                                    Renal water loss

                                                                                                                                    Renal disease

                                                                                                                                    Diuretics

                                                                                                                                    Diabetes insipidus

                                                                                                                                    High

                                                                                                                                    Iatrogenic sodium administration

                                                                                                                                    Mineralocorticoid excess

                                                                                                                                    Aldosteronism

                                                                                                                                    Cushingrsquos disease

                                                                                                                                    Congenital adrenal

                                                                                                                                    hyperplasia

                                                                                                                                    Low

                                                                                                                                    Nonrenal water loss

                                                                                                                                    Skin

                                                                                                                                    Gastrointestinal losses

                                                                                                                                    Renal water losses

                                                                                                                                    Renal (tubular) Diuretics

                                                                                                                                    Osmotic diuretics

                                                                                                                                    Diabetes insipidus

                                                                                                                                    Adrenal failure

                                                                                                                                    Asymptomatic

                                                                                                                                    Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                                                    Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                                    Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                                                    Body system hypernatremia

                                                                                                                                    Treatment

                                                                                                                                    Normal saline in hypovolemic patients

                                                                                                                                    Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                                                    saline or entral water)

                                                                                                                                    Water deficit (L)= times TBW

                                                                                                                                    The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                                                    Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                                                    Serum sodium-140

                                                                                                                                    140

                                                                                                                                    The rate of fluid administration

                                                                                                                                    1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                                                    2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                                                    Hyponatremia Nalt135mEqL

                                                                                                                                    Causes

                                                                                                                                    1 Sodium depletion

                                                                                                                                    2 Sodium dilution

                                                                                                                                    bull Incidence = 45

                                                                                                                                    bull After surgery=1

                                                                                                                                    bull Mortality = 2 times normal

                                                                                                                                    Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                                                    volume deficit

                                                                                                                                    Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                                    Sign and symptoms

                                                                                                                                    bull CNS symptom when Nalt123 meql

                                                                                                                                    bull Cardiac symptom when Nalt100 meql

                                                                                                                                    For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                                    Body System Hyponatremia

                                                                                                                                    central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                                    reflexes seizures coma increased intracranial pressure

                                                                                                                                    Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                                    Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                                    Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                                    intracranial pressure

                                                                                                                                    Tissue Lacrimation salivation

                                                                                                                                    Renal Oliguria

                                                                                                                                    Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                                    Treatment

                                                                                                                                    1=Depend on ECF

                                                                                                                                    2=CNS sign

                                                                                                                                    Treatment

                                                                                                                                    1 Asymptomatic increase the sodium level by no more than

                                                                                                                                    05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                                    2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                                    more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                                    meqL or neurologic symptoms are improved

                                                                                                                                    Rapid correction of hyponatremia

                                                                                                                                    Pontine myelinolysis

                                                                                                                                    Seizures weaknessparesis akinetic

                                                                                                                                    movements unresponsiveness

                                                                                                                                    Permanent brain damage

                                                                                                                                    Death

                                                                                                                                    Dose

                                                                                                                                    Na deficit meq =(140- Na meql) TBW

                                                                                                                                    باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                                    شود اصالح آهسته سپس

                                                                                                                                    Potassium abnormalities

                                                                                                                                    bull The average dietary intake of potassium 50-100meqd

                                                                                                                                    bull The average renal excretion of potassium 10-700 meqd

                                                                                                                                    - 2 of the total body potassium in ECF (45meqL)

                                                                                                                                    - Factors that influence serum potassium

                                                                                                                                    1 Surgical stress

                                                                                                                                    2 Injury

                                                                                                                                    3 Acidosis

                                                                                                                                    4 Tissue catabolism

                                                                                                                                    Hyperkalemia

                                                                                                                                    The normal range of serum potassium 35-5 meqL

                                                                                                                                    Etiology of Hyperkalemia

                                                                                                                                    Increased intake Potassium supplementation

                                                                                                                                    Blood transfusions

                                                                                                                                    Endogenous loaddestruction

                                                                                                                                    hemolysis rhabdomyolysis

                                                                                                                                    cruch injury gastrointestinal hemorrhage

                                                                                                                                    Increased release Acidosis

                                                                                                                                    Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                    Renal insufficiencyfailure

                                                                                                                                    Clinical manifestation of hyperkalemia

                                                                                                                                    System hyperkalemia

                                                                                                                                    Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                    Neuromuscular weakness paralysis respiratory failure

                                                                                                                                    Cardiovascular Arrhythmia arrest

                                                                                                                                    ECG changes Peaked T waves (early change)

                                                                                                                                    Flattened P wave

                                                                                                                                    Prolonged PR interval (first-degree block)

                                                                                                                                    Widened QRS complex

                                                                                                                                    Sine wave formation

                                                                                                                                    Ventricular fibrillation

                                                                                                                                    Treatment

                                                                                                                                    Treatment of symptomatic hyperkalemia

                                                                                                                                    Potassium removal Kayexalate

                                                                                                                                    Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                    Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                    Dialysis

                                                                                                                                    Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                    Bicarbonate 1 vial intravenous

                                                                                                                                    Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                    HypokalemiaEtiology

                                                                                                                                    inadequate intake

                                                                                                                                    Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                    total parenteral nutrition

                                                                                                                                    Excessive potassium excretion

                                                                                                                                    Hyperaldosteronism

                                                                                                                                    Medications

                                                                                                                                    Gastrointestinal losses

                                                                                                                                    Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                    Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                    nasogastric output)

                                                                                                                                    Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                    Potassium changes associated with alkalosis

                                                                                                                                    Potassium decrease by 03 meqL for every 01

                                                                                                                                    increase in PH above normal

                                                                                                                                    Magnesium Depletion

                                                                                                                                    (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                    Renal potassium wastage

                                                                                                                                    Hypokalemia

                                                                                                                                    Magnesium Depletion

                                                                                                                                    (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                    Renal potassium wastage

                                                                                                                                    Hypokalemia

                                                                                                                                    Clinical Manifestation of Abnormalities in potassium

                                                                                                                                    System hypokalemia

                                                                                                                                    Gastrointestinal Ileus constipation

                                                                                                                                    Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                    paralysis

                                                                                                                                    Cardiovascular Arrest

                                                                                                                                    ECG changes U-waves

                                                                                                                                    T-wave flattening

                                                                                                                                    ST-segment changes

                                                                                                                                    Arrhythmias

                                                                                                                                    Treatment

                                                                                                                                    Potassium

                                                                                                                                    Serum potassium level lt40 mEqL

                                                                                                                                    Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                    times 1 doses

                                                                                                                                    Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                    Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                    Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                    asymptomatic replace as per above protocol

                                                                                                                                    Electrolyte Replacement Therapy Protocol

                                                                                                                                    bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                    bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                    Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                    ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                    عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                    صاف 2 عضالت انقباض

                                                                                                                                    هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                    انعقاد 4

                                                                                                                                    یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                    عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                    ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                    میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                    ( شود می پیوند شده

                                                                                                                                    هیپوکلسمی عالئم

                                                                                                                                    رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                    سایرعالئم

                                                                                                                                    قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                    درمان

                                                                                                                                    ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                    Cagt55meql هيپركلسمي

                                                                                                                                    هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                    عالئم

                                                                                                                                    bullGI

                                                                                                                                    bullCardiovascular bullRenal (polyuria)

                                                                                                                                    bullCNS

                                                                                                                                    قلبی عالئم

                                                                                                                                    bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                    QRS شدن )Q-Tوكوتاه

                                                                                                                                    درمان

                                                                                                                                    ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                    الزیکس2

                                                                                                                                    تونین 3 کلسی

                                                                                                                                    کورتون4

                                                                                                                                    دیالیز5

                                                                                                                                    Magnesium Abnormalities

                                                                                                                                    Normal dietary intake 20meq (240mg)

                                                                                                                                    Excretion in both the feces and urine

                                                                                                                                    Normal serum level 19-25 mgdL

                                                                                                                                    منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                    تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                    bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                    Hypermagnesemia

                                                                                                                                    Etiology

                                                                                                                                    1 Impaired renal function

                                                                                                                                    2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                    Clinical manifestation hypermanesemia

                                                                                                                                    System hypermanesemia

                                                                                                                                    Gastrointestinal Nauseavomiting

                                                                                                                                    Neuromuscular weakness lethargy Decreased

                                                                                                                                    reflexes

                                                                                                                                    Cardiovascular Hypotension arrest

                                                                                                                                    ECG changes Increased PR interval

                                                                                                                                    Widened QRS complex

                                                                                                                                    Elevated T waves

                                                                                                                                    Treatment

                                                                                                                                    1 Withhold exogenous sources of magnesium

                                                                                                                                    2 Correct volume deficit

                                                                                                                                    3 Correct acidosis if present

                                                                                                                                    4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                    5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                    عالئم

                                                                                                                                    bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                    meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                    meqL

                                                                                                                                    Hypomagnesemia

                                                                                                                                    Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                    homeostasis

                                                                                                                                    Etiology

                                                                                                                                    1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                    inadequate supplementation of magnesium)

                                                                                                                                    2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                    3 GI losses (diarrhea)

                                                                                                                                    4 Malabsorption

                                                                                                                                    5 Acute pancreatitis

                                                                                                                                    6 Diabetic ketoacidosis

                                                                                                                                    7 Primary aldosteronism

                                                                                                                                    Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                    1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                    2 Delirium and seizures in severe deficiency

                                                                                                                                    3 ECG changes Prolonged QT and PR interval

                                                                                                                                    ST-segment depression

                                                                                                                                    Flattening or inversion of P waves

                                                                                                                                    Torsades de pointes

                                                                                                                                    Arrhythmia

                                                                                                                                    Treatment

                                                                                                                                    1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                    2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                    Message for Today

                                                                                                                                    ICF

                                                                                                                                    Interstitial

                                                                                                                                    Pla

                                                                                                                                    sma

                                                                                                                                    5 Dex

                                                                                                                                    bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                    • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                    • Slide 2
                                                                                                                                    • Slide 3
                                                                                                                                    • Slide 4
                                                                                                                                    • Total Body Water
                                                                                                                                    • Body Fluid Compartments
                                                                                                                                    • Total body water (TBW)
                                                                                                                                    • Body compartment fluid
                                                                                                                                    • Example men with 70kg
                                                                                                                                    • Fluid compartments
                                                                                                                                    • Slide 11
                                                                                                                                    • Slide 12
                                                                                                                                    • Slide 13
                                                                                                                                    • Slide 14
                                                                                                                                    • Slide 15
                                                                                                                                    • Colloid osmotic pressure
                                                                                                                                    • Slide 17
                                                                                                                                    • Slide 18
                                                                                                                                    • Slide 19
                                                                                                                                    • Cell Membrane
                                                                                                                                    • Slide 21
                                                                                                                                    • Slide 22
                                                                                                                                    • Slide 23
                                                                                                                                    • Slide 24
                                                                                                                                    • Slide 25
                                                                                                                                    • Composition of Fluid Compartments
                                                                                                                                    • Composition of Body Fluids
                                                                                                                                    • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                    • Reasons for fluid therapy
                                                                                                                                    • ارزیابی حجم مایع داخل عروقی
                                                                                                                                    • محلولهای وریدی
                                                                                                                                    • Fluids
                                                                                                                                    • Slide 33
                                                                                                                                    • Slide 34
                                                                                                                                    • Slide 35
                                                                                                                                    • Crystalloids
                                                                                                                                    • Colloid Solutions
                                                                                                                                    • رینگر لاکتات
                                                                                                                                    • 09Nacl
                                                                                                                                    • Postoperative (maintenance)
                                                                                                                                    • Slide 41
                                                                                                                                    • Preexisting fluid deficits
                                                                                                                                    • Maintenance requirements
                                                                                                                                    • Surgical fluid losses
                                                                                                                                    • Third space loss
                                                                                                                                    • Crystalloid solution
                                                                                                                                    • Colloids
                                                                                                                                    • Complications
                                                                                                                                    • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                    • Colloid versus crystalloid solutions
                                                                                                                                    • Transfusion consideration
                                                                                                                                    • اختلال در حجم مایعات بدن
                                                                                                                                    • Fluid volume deficit (FVD)
                                                                                                                                    • DEHYDRATION
                                                                                                                                    • علل کاهش حجم خارج سلولی
                                                                                                                                    • Signs of Hypovolemia
                                                                                                                                    • Clinical Diagnosis of Hypovolemia
                                                                                                                                    • Signs of Hypervolemia
                                                                                                                                    • Management of Hypervolemia
                                                                                                                                    • Fluid Management
                                                                                                                                    • Electrolyte physiology
                                                                                                                                    • Sodium physiology
                                                                                                                                    • Osmotic Pressure
                                                                                                                                    • Concentration
                                                                                                                                    • Hypernatremia
                                                                                                                                    • - Hypernatremia
                                                                                                                                    • Slide 67
                                                                                                                                    • Slide 68
                                                                                                                                    • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                    • Treatment
                                                                                                                                    • Water deficit (L)= times TBW
                                                                                                                                    • The rate of fluid administration
                                                                                                                                    • Hyponatremia Nalt135mEqL
                                                                                                                                    • Slide 74
                                                                                                                                    • Sodium depletion
                                                                                                                                    • Sodium dilution
                                                                                                                                    • Sign and symptoms
                                                                                                                                    • Slide 78
                                                                                                                                    • Treatment
                                                                                                                                    • Slide 80
                                                                                                                                    • Slide 81
                                                                                                                                    • Dose
                                                                                                                                    • Potassium abnormalities
                                                                                                                                    • Hyperkalemia
                                                                                                                                    • Clinical manifestation of hyperkalemia
                                                                                                                                    • Slide 86
                                                                                                                                    • Slide 87
                                                                                                                                    • Hypokalemia
                                                                                                                                    • Potassium changes associated with alkalosis
                                                                                                                                    • Slide 90
                                                                                                                                    • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                    • Slide 92
                                                                                                                                    • Calcium
                                                                                                                                    • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                    • علائم هیپوکلسمی
                                                                                                                                    • Slide 96
                                                                                                                                    • Slide 97
                                                                                                                                    • Slide 98
                                                                                                                                    • Slide 99
                                                                                                                                    • سایرعلائم
                                                                                                                                    • درمان
                                                                                                                                    • هيپركلسمي Cagt55meql
                                                                                                                                    • علائم
                                                                                                                                    • علائم قلبی
                                                                                                                                    • Slide 105
                                                                                                                                    • Magnesium Abnormalities
                                                                                                                                    • منیزیوم
                                                                                                                                    • Hypermagnesemia
                                                                                                                                    • Clinical manifestation hypermanesemia
                                                                                                                                    • Slide 110
                                                                                                                                    • Slide 111
                                                                                                                                    • Hypomagnesemia
                                                                                                                                    • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                    • Slide 114
                                                                                                                                    • Message for Today
                                                                                                                                    • Slide 116

                                                                                                                                      Asymptomatic

                                                                                                                                      Hypernatremia Symptomatic (Nagt160 meqL)

                                                                                                                                      Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                                      Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                                                      Body system hypernatremia

                                                                                                                                      Treatment

                                                                                                                                      Normal saline in hypovolemic patients

                                                                                                                                      Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                                                      saline or entral water)

                                                                                                                                      Water deficit (L)= times TBW

                                                                                                                                      The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                                                      Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                                                      Serum sodium-140

                                                                                                                                      140

                                                                                                                                      The rate of fluid administration

                                                                                                                                      1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                                                      2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                                                      Hyponatremia Nalt135mEqL

                                                                                                                                      Causes

                                                                                                                                      1 Sodium depletion

                                                                                                                                      2 Sodium dilution

                                                                                                                                      bull Incidence = 45

                                                                                                                                      bull After surgery=1

                                                                                                                                      bull Mortality = 2 times normal

                                                                                                                                      Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                                                      volume deficit

                                                                                                                                      Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                                      Sign and symptoms

                                                                                                                                      bull CNS symptom when Nalt123 meql

                                                                                                                                      bull Cardiac symptom when Nalt100 meql

                                                                                                                                      For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                                      Body System Hyponatremia

                                                                                                                                      central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                                      reflexes seizures coma increased intracranial pressure

                                                                                                                                      Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                                      Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                                      Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                                      intracranial pressure

                                                                                                                                      Tissue Lacrimation salivation

                                                                                                                                      Renal Oliguria

                                                                                                                                      Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                                      Treatment

                                                                                                                                      1=Depend on ECF

                                                                                                                                      2=CNS sign

                                                                                                                                      Treatment

                                                                                                                                      1 Asymptomatic increase the sodium level by no more than

                                                                                                                                      05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                                      2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                                      more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                                      meqL or neurologic symptoms are improved

                                                                                                                                      Rapid correction of hyponatremia

                                                                                                                                      Pontine myelinolysis

                                                                                                                                      Seizures weaknessparesis akinetic

                                                                                                                                      movements unresponsiveness

                                                                                                                                      Permanent brain damage

                                                                                                                                      Death

                                                                                                                                      Dose

                                                                                                                                      Na deficit meq =(140- Na meql) TBW

                                                                                                                                      باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                                      شود اصالح آهسته سپس

                                                                                                                                      Potassium abnormalities

                                                                                                                                      bull The average dietary intake of potassium 50-100meqd

                                                                                                                                      bull The average renal excretion of potassium 10-700 meqd

                                                                                                                                      - 2 of the total body potassium in ECF (45meqL)

                                                                                                                                      - Factors that influence serum potassium

                                                                                                                                      1 Surgical stress

                                                                                                                                      2 Injury

                                                                                                                                      3 Acidosis

                                                                                                                                      4 Tissue catabolism

                                                                                                                                      Hyperkalemia

                                                                                                                                      The normal range of serum potassium 35-5 meqL

                                                                                                                                      Etiology of Hyperkalemia

                                                                                                                                      Increased intake Potassium supplementation

                                                                                                                                      Blood transfusions

                                                                                                                                      Endogenous loaddestruction

                                                                                                                                      hemolysis rhabdomyolysis

                                                                                                                                      cruch injury gastrointestinal hemorrhage

                                                                                                                                      Increased release Acidosis

                                                                                                                                      Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                      Renal insufficiencyfailure

                                                                                                                                      Clinical manifestation of hyperkalemia

                                                                                                                                      System hyperkalemia

                                                                                                                                      Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                      Neuromuscular weakness paralysis respiratory failure

                                                                                                                                      Cardiovascular Arrhythmia arrest

                                                                                                                                      ECG changes Peaked T waves (early change)

                                                                                                                                      Flattened P wave

                                                                                                                                      Prolonged PR interval (first-degree block)

                                                                                                                                      Widened QRS complex

                                                                                                                                      Sine wave formation

                                                                                                                                      Ventricular fibrillation

                                                                                                                                      Treatment

                                                                                                                                      Treatment of symptomatic hyperkalemia

                                                                                                                                      Potassium removal Kayexalate

                                                                                                                                      Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                      Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                      Dialysis

                                                                                                                                      Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                      Bicarbonate 1 vial intravenous

                                                                                                                                      Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                      HypokalemiaEtiology

                                                                                                                                      inadequate intake

                                                                                                                                      Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                      total parenteral nutrition

                                                                                                                                      Excessive potassium excretion

                                                                                                                                      Hyperaldosteronism

                                                                                                                                      Medications

                                                                                                                                      Gastrointestinal losses

                                                                                                                                      Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                      Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                      nasogastric output)

                                                                                                                                      Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                      Potassium changes associated with alkalosis

                                                                                                                                      Potassium decrease by 03 meqL for every 01

                                                                                                                                      increase in PH above normal

                                                                                                                                      Magnesium Depletion

                                                                                                                                      (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                      Renal potassium wastage

                                                                                                                                      Hypokalemia

                                                                                                                                      Magnesium Depletion

                                                                                                                                      (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                      Renal potassium wastage

                                                                                                                                      Hypokalemia

                                                                                                                                      Clinical Manifestation of Abnormalities in potassium

                                                                                                                                      System hypokalemia

                                                                                                                                      Gastrointestinal Ileus constipation

                                                                                                                                      Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                      paralysis

                                                                                                                                      Cardiovascular Arrest

                                                                                                                                      ECG changes U-waves

                                                                                                                                      T-wave flattening

                                                                                                                                      ST-segment changes

                                                                                                                                      Arrhythmias

                                                                                                                                      Treatment

                                                                                                                                      Potassium

                                                                                                                                      Serum potassium level lt40 mEqL

                                                                                                                                      Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                      times 1 doses

                                                                                                                                      Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                      Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                      Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                      asymptomatic replace as per above protocol

                                                                                                                                      Electrolyte Replacement Therapy Protocol

                                                                                                                                      bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                      bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                      Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                      ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                      عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                      صاف 2 عضالت انقباض

                                                                                                                                      هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                      انعقاد 4

                                                                                                                                      یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                      عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                      ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                      میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                      ( شود می پیوند شده

                                                                                                                                      هیپوکلسمی عالئم

                                                                                                                                      رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                      سایرعالئم

                                                                                                                                      قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                      درمان

                                                                                                                                      ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                      Cagt55meql هيپركلسمي

                                                                                                                                      هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                      عالئم

                                                                                                                                      bullGI

                                                                                                                                      bullCardiovascular bullRenal (polyuria)

                                                                                                                                      bullCNS

                                                                                                                                      قلبی عالئم

                                                                                                                                      bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                      QRS شدن )Q-Tوكوتاه

                                                                                                                                      درمان

                                                                                                                                      ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                      الزیکس2

                                                                                                                                      تونین 3 کلسی

                                                                                                                                      کورتون4

                                                                                                                                      دیالیز5

                                                                                                                                      Magnesium Abnormalities

                                                                                                                                      Normal dietary intake 20meq (240mg)

                                                                                                                                      Excretion in both the feces and urine

                                                                                                                                      Normal serum level 19-25 mgdL

                                                                                                                                      منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                      تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                      bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                      Hypermagnesemia

                                                                                                                                      Etiology

                                                                                                                                      1 Impaired renal function

                                                                                                                                      2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                      Clinical manifestation hypermanesemia

                                                                                                                                      System hypermanesemia

                                                                                                                                      Gastrointestinal Nauseavomiting

                                                                                                                                      Neuromuscular weakness lethargy Decreased

                                                                                                                                      reflexes

                                                                                                                                      Cardiovascular Hypotension arrest

                                                                                                                                      ECG changes Increased PR interval

                                                                                                                                      Widened QRS complex

                                                                                                                                      Elevated T waves

                                                                                                                                      Treatment

                                                                                                                                      1 Withhold exogenous sources of magnesium

                                                                                                                                      2 Correct volume deficit

                                                                                                                                      3 Correct acidosis if present

                                                                                                                                      4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                      5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                      عالئم

                                                                                                                                      bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                      meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                      meqL

                                                                                                                                      Hypomagnesemia

                                                                                                                                      Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                      homeostasis

                                                                                                                                      Etiology

                                                                                                                                      1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                      inadequate supplementation of magnesium)

                                                                                                                                      2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                      3 GI losses (diarrhea)

                                                                                                                                      4 Malabsorption

                                                                                                                                      5 Acute pancreatitis

                                                                                                                                      6 Diabetic ketoacidosis

                                                                                                                                      7 Primary aldosteronism

                                                                                                                                      Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                      1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                      2 Delirium and seizures in severe deficiency

                                                                                                                                      3 ECG changes Prolonged QT and PR interval

                                                                                                                                      ST-segment depression

                                                                                                                                      Flattening or inversion of P waves

                                                                                                                                      Torsades de pointes

                                                                                                                                      Arrhythmia

                                                                                                                                      Treatment

                                                                                                                                      1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                      2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                      Message for Today

                                                                                                                                      ICF

                                                                                                                                      Interstitial

                                                                                                                                      Pla

                                                                                                                                      sma

                                                                                                                                      5 Dex

                                                                                                                                      bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                      • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                      • Slide 2
                                                                                                                                      • Slide 3
                                                                                                                                      • Slide 4
                                                                                                                                      • Total Body Water
                                                                                                                                      • Body Fluid Compartments
                                                                                                                                      • Total body water (TBW)
                                                                                                                                      • Body compartment fluid
                                                                                                                                      • Example men with 70kg
                                                                                                                                      • Fluid compartments
                                                                                                                                      • Slide 11
                                                                                                                                      • Slide 12
                                                                                                                                      • Slide 13
                                                                                                                                      • Slide 14
                                                                                                                                      • Slide 15
                                                                                                                                      • Colloid osmotic pressure
                                                                                                                                      • Slide 17
                                                                                                                                      • Slide 18
                                                                                                                                      • Slide 19
                                                                                                                                      • Cell Membrane
                                                                                                                                      • Slide 21
                                                                                                                                      • Slide 22
                                                                                                                                      • Slide 23
                                                                                                                                      • Slide 24
                                                                                                                                      • Slide 25
                                                                                                                                      • Composition of Fluid Compartments
                                                                                                                                      • Composition of Body Fluids
                                                                                                                                      • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                      • Reasons for fluid therapy
                                                                                                                                      • ارزیابی حجم مایع داخل عروقی
                                                                                                                                      • محلولهای وریدی
                                                                                                                                      • Fluids
                                                                                                                                      • Slide 33
                                                                                                                                      • Slide 34
                                                                                                                                      • Slide 35
                                                                                                                                      • Crystalloids
                                                                                                                                      • Colloid Solutions
                                                                                                                                      • رینگر لاکتات
                                                                                                                                      • 09Nacl
                                                                                                                                      • Postoperative (maintenance)
                                                                                                                                      • Slide 41
                                                                                                                                      • Preexisting fluid deficits
                                                                                                                                      • Maintenance requirements
                                                                                                                                      • Surgical fluid losses
                                                                                                                                      • Third space loss
                                                                                                                                      • Crystalloid solution
                                                                                                                                      • Colloids
                                                                                                                                      • Complications
                                                                                                                                      • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                      • Colloid versus crystalloid solutions
                                                                                                                                      • Transfusion consideration
                                                                                                                                      • اختلال در حجم مایعات بدن
                                                                                                                                      • Fluid volume deficit (FVD)
                                                                                                                                      • DEHYDRATION
                                                                                                                                      • علل کاهش حجم خارج سلولی
                                                                                                                                      • Signs of Hypovolemia
                                                                                                                                      • Clinical Diagnosis of Hypovolemia
                                                                                                                                      • Signs of Hypervolemia
                                                                                                                                      • Management of Hypervolemia
                                                                                                                                      • Fluid Management
                                                                                                                                      • Electrolyte physiology
                                                                                                                                      • Sodium physiology
                                                                                                                                      • Osmotic Pressure
                                                                                                                                      • Concentration
                                                                                                                                      • Hypernatremia
                                                                                                                                      • - Hypernatremia
                                                                                                                                      • Slide 67
                                                                                                                                      • Slide 68
                                                                                                                                      • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                      • Treatment
                                                                                                                                      • Water deficit (L)= times TBW
                                                                                                                                      • The rate of fluid administration
                                                                                                                                      • Hyponatremia Nalt135mEqL
                                                                                                                                      • Slide 74
                                                                                                                                      • Sodium depletion
                                                                                                                                      • Sodium dilution
                                                                                                                                      • Sign and symptoms
                                                                                                                                      • Slide 78
                                                                                                                                      • Treatment
                                                                                                                                      • Slide 80
                                                                                                                                      • Slide 81
                                                                                                                                      • Dose
                                                                                                                                      • Potassium abnormalities
                                                                                                                                      • Hyperkalemia
                                                                                                                                      • Clinical manifestation of hyperkalemia
                                                                                                                                      • Slide 86
                                                                                                                                      • Slide 87
                                                                                                                                      • Hypokalemia
                                                                                                                                      • Potassium changes associated with alkalosis
                                                                                                                                      • Slide 90
                                                                                                                                      • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                      • Slide 92
                                                                                                                                      • Calcium
                                                                                                                                      • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                      • علائم هیپوکلسمی
                                                                                                                                      • Slide 96
                                                                                                                                      • Slide 97
                                                                                                                                      • Slide 98
                                                                                                                                      • Slide 99
                                                                                                                                      • سایرعلائم
                                                                                                                                      • درمان
                                                                                                                                      • هيپركلسمي Cagt55meql
                                                                                                                                      • علائم
                                                                                                                                      • علائم قلبی
                                                                                                                                      • Slide 105
                                                                                                                                      • Magnesium Abnormalities
                                                                                                                                      • منیزیوم
                                                                                                                                      • Hypermagnesemia
                                                                                                                                      • Clinical manifestation hypermanesemia
                                                                                                                                      • Slide 110
                                                                                                                                      • Slide 111
                                                                                                                                      • Hypomagnesemia
                                                                                                                                      • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                      • Slide 114
                                                                                                                                      • Message for Today
                                                                                                                                      • Slide 116

                                                                                                                                        Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                                        Central nervous system Restlessness lethargy ataxia irritability tonic spasms delirium seizures coma Musculoskeletal weaknessCardiovascular Tachycardia hypotension syncopeTissue Dry sticky mucous membranes red swollen tongue decreased saliva and tearsRenal Oliguria Metabolic Fever

                                                                                                                                        Body system hypernatremia

                                                                                                                                        Treatment

                                                                                                                                        Normal saline in hypovolemic patients

                                                                                                                                        Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                                                        saline or entral water)

                                                                                                                                        Water deficit (L)= times TBW

                                                                                                                                        The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                                                        Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                                                        Serum sodium-140

                                                                                                                                        140

                                                                                                                                        The rate of fluid administration

                                                                                                                                        1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                                                        2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                                                        Hyponatremia Nalt135mEqL

                                                                                                                                        Causes

                                                                                                                                        1 Sodium depletion

                                                                                                                                        2 Sodium dilution

                                                                                                                                        bull Incidence = 45

                                                                                                                                        bull After surgery=1

                                                                                                                                        bull Mortality = 2 times normal

                                                                                                                                        Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                                                        volume deficit

                                                                                                                                        Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                                        Sign and symptoms

                                                                                                                                        bull CNS symptom when Nalt123 meql

                                                                                                                                        bull Cardiac symptom when Nalt100 meql

                                                                                                                                        For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                                        Body System Hyponatremia

                                                                                                                                        central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                                        reflexes seizures coma increased intracranial pressure

                                                                                                                                        Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                                        Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                                        Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                                        intracranial pressure

                                                                                                                                        Tissue Lacrimation salivation

                                                                                                                                        Renal Oliguria

                                                                                                                                        Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                                        Treatment

                                                                                                                                        1=Depend on ECF

                                                                                                                                        2=CNS sign

                                                                                                                                        Treatment

                                                                                                                                        1 Asymptomatic increase the sodium level by no more than

                                                                                                                                        05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                                        2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                                        more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                                        meqL or neurologic symptoms are improved

                                                                                                                                        Rapid correction of hyponatremia

                                                                                                                                        Pontine myelinolysis

                                                                                                                                        Seizures weaknessparesis akinetic

                                                                                                                                        movements unresponsiveness

                                                                                                                                        Permanent brain damage

                                                                                                                                        Death

                                                                                                                                        Dose

                                                                                                                                        Na deficit meq =(140- Na meql) TBW

                                                                                                                                        باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                                        شود اصالح آهسته سپس

                                                                                                                                        Potassium abnormalities

                                                                                                                                        bull The average dietary intake of potassium 50-100meqd

                                                                                                                                        bull The average renal excretion of potassium 10-700 meqd

                                                                                                                                        - 2 of the total body potassium in ECF (45meqL)

                                                                                                                                        - Factors that influence serum potassium

                                                                                                                                        1 Surgical stress

                                                                                                                                        2 Injury

                                                                                                                                        3 Acidosis

                                                                                                                                        4 Tissue catabolism

                                                                                                                                        Hyperkalemia

                                                                                                                                        The normal range of serum potassium 35-5 meqL

                                                                                                                                        Etiology of Hyperkalemia

                                                                                                                                        Increased intake Potassium supplementation

                                                                                                                                        Blood transfusions

                                                                                                                                        Endogenous loaddestruction

                                                                                                                                        hemolysis rhabdomyolysis

                                                                                                                                        cruch injury gastrointestinal hemorrhage

                                                                                                                                        Increased release Acidosis

                                                                                                                                        Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                        Renal insufficiencyfailure

                                                                                                                                        Clinical manifestation of hyperkalemia

                                                                                                                                        System hyperkalemia

                                                                                                                                        Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                        Neuromuscular weakness paralysis respiratory failure

                                                                                                                                        Cardiovascular Arrhythmia arrest

                                                                                                                                        ECG changes Peaked T waves (early change)

                                                                                                                                        Flattened P wave

                                                                                                                                        Prolonged PR interval (first-degree block)

                                                                                                                                        Widened QRS complex

                                                                                                                                        Sine wave formation

                                                                                                                                        Ventricular fibrillation

                                                                                                                                        Treatment

                                                                                                                                        Treatment of symptomatic hyperkalemia

                                                                                                                                        Potassium removal Kayexalate

                                                                                                                                        Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                        Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                        Dialysis

                                                                                                                                        Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                        Bicarbonate 1 vial intravenous

                                                                                                                                        Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                        HypokalemiaEtiology

                                                                                                                                        inadequate intake

                                                                                                                                        Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                        total parenteral nutrition

                                                                                                                                        Excessive potassium excretion

                                                                                                                                        Hyperaldosteronism

                                                                                                                                        Medications

                                                                                                                                        Gastrointestinal losses

                                                                                                                                        Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                        Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                        nasogastric output)

                                                                                                                                        Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                        Potassium changes associated with alkalosis

                                                                                                                                        Potassium decrease by 03 meqL for every 01

                                                                                                                                        increase in PH above normal

                                                                                                                                        Magnesium Depletion

                                                                                                                                        (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                        Renal potassium wastage

                                                                                                                                        Hypokalemia

                                                                                                                                        Magnesium Depletion

                                                                                                                                        (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                        Renal potassium wastage

                                                                                                                                        Hypokalemia

                                                                                                                                        Clinical Manifestation of Abnormalities in potassium

                                                                                                                                        System hypokalemia

                                                                                                                                        Gastrointestinal Ileus constipation

                                                                                                                                        Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                        paralysis

                                                                                                                                        Cardiovascular Arrest

                                                                                                                                        ECG changes U-waves

                                                                                                                                        T-wave flattening

                                                                                                                                        ST-segment changes

                                                                                                                                        Arrhythmias

                                                                                                                                        Treatment

                                                                                                                                        Potassium

                                                                                                                                        Serum potassium level lt40 mEqL

                                                                                                                                        Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                        times 1 doses

                                                                                                                                        Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                        Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                        Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                        asymptomatic replace as per above protocol

                                                                                                                                        Electrolyte Replacement Therapy Protocol

                                                                                                                                        bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                        bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                        Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                        ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                        عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                        صاف 2 عضالت انقباض

                                                                                                                                        هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                        انعقاد 4

                                                                                                                                        یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                        عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                        ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                        میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                        ( شود می پیوند شده

                                                                                                                                        هیپوکلسمی عالئم

                                                                                                                                        رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                        سایرعالئم

                                                                                                                                        قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                        درمان

                                                                                                                                        ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                        Cagt55meql هيپركلسمي

                                                                                                                                        هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                        عالئم

                                                                                                                                        bullGI

                                                                                                                                        bullCardiovascular bullRenal (polyuria)

                                                                                                                                        bullCNS

                                                                                                                                        قلبی عالئم

                                                                                                                                        bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                        QRS شدن )Q-Tوكوتاه

                                                                                                                                        درمان

                                                                                                                                        ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                        الزیکس2

                                                                                                                                        تونین 3 کلسی

                                                                                                                                        کورتون4

                                                                                                                                        دیالیز5

                                                                                                                                        Magnesium Abnormalities

                                                                                                                                        Normal dietary intake 20meq (240mg)

                                                                                                                                        Excretion in both the feces and urine

                                                                                                                                        Normal serum level 19-25 mgdL

                                                                                                                                        منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                        تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                        bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                        Hypermagnesemia

                                                                                                                                        Etiology

                                                                                                                                        1 Impaired renal function

                                                                                                                                        2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                        Clinical manifestation hypermanesemia

                                                                                                                                        System hypermanesemia

                                                                                                                                        Gastrointestinal Nauseavomiting

                                                                                                                                        Neuromuscular weakness lethargy Decreased

                                                                                                                                        reflexes

                                                                                                                                        Cardiovascular Hypotension arrest

                                                                                                                                        ECG changes Increased PR interval

                                                                                                                                        Widened QRS complex

                                                                                                                                        Elevated T waves

                                                                                                                                        Treatment

                                                                                                                                        1 Withhold exogenous sources of magnesium

                                                                                                                                        2 Correct volume deficit

                                                                                                                                        3 Correct acidosis if present

                                                                                                                                        4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                        5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                        عالئم

                                                                                                                                        bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                        meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                        meqL

                                                                                                                                        Hypomagnesemia

                                                                                                                                        Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                        homeostasis

                                                                                                                                        Etiology

                                                                                                                                        1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                        inadequate supplementation of magnesium)

                                                                                                                                        2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                        3 GI losses (diarrhea)

                                                                                                                                        4 Malabsorption

                                                                                                                                        5 Acute pancreatitis

                                                                                                                                        6 Diabetic ketoacidosis

                                                                                                                                        7 Primary aldosteronism

                                                                                                                                        Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                        1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                        2 Delirium and seizures in severe deficiency

                                                                                                                                        3 ECG changes Prolonged QT and PR interval

                                                                                                                                        ST-segment depression

                                                                                                                                        Flattening or inversion of P waves

                                                                                                                                        Torsades de pointes

                                                                                                                                        Arrhythmia

                                                                                                                                        Treatment

                                                                                                                                        1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                        2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                        Message for Today

                                                                                                                                        ICF

                                                                                                                                        Interstitial

                                                                                                                                        Pla

                                                                                                                                        sma

                                                                                                                                        5 Dex

                                                                                                                                        bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                        • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                        • Slide 2
                                                                                                                                        • Slide 3
                                                                                                                                        • Slide 4
                                                                                                                                        • Total Body Water
                                                                                                                                        • Body Fluid Compartments
                                                                                                                                        • Total body water (TBW)
                                                                                                                                        • Body compartment fluid
                                                                                                                                        • Example men with 70kg
                                                                                                                                        • Fluid compartments
                                                                                                                                        • Slide 11
                                                                                                                                        • Slide 12
                                                                                                                                        • Slide 13
                                                                                                                                        • Slide 14
                                                                                                                                        • Slide 15
                                                                                                                                        • Colloid osmotic pressure
                                                                                                                                        • Slide 17
                                                                                                                                        • Slide 18
                                                                                                                                        • Slide 19
                                                                                                                                        • Cell Membrane
                                                                                                                                        • Slide 21
                                                                                                                                        • Slide 22
                                                                                                                                        • Slide 23
                                                                                                                                        • Slide 24
                                                                                                                                        • Slide 25
                                                                                                                                        • Composition of Fluid Compartments
                                                                                                                                        • Composition of Body Fluids
                                                                                                                                        • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                        • Reasons for fluid therapy
                                                                                                                                        • ارزیابی حجم مایع داخل عروقی
                                                                                                                                        • محلولهای وریدی
                                                                                                                                        • Fluids
                                                                                                                                        • Slide 33
                                                                                                                                        • Slide 34
                                                                                                                                        • Slide 35
                                                                                                                                        • Crystalloids
                                                                                                                                        • Colloid Solutions
                                                                                                                                        • رینگر لاکتات
                                                                                                                                        • 09Nacl
                                                                                                                                        • Postoperative (maintenance)
                                                                                                                                        • Slide 41
                                                                                                                                        • Preexisting fluid deficits
                                                                                                                                        • Maintenance requirements
                                                                                                                                        • Surgical fluid losses
                                                                                                                                        • Third space loss
                                                                                                                                        • Crystalloid solution
                                                                                                                                        • Colloids
                                                                                                                                        • Complications
                                                                                                                                        • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                        • Colloid versus crystalloid solutions
                                                                                                                                        • Transfusion consideration
                                                                                                                                        • اختلال در حجم مایعات بدن
                                                                                                                                        • Fluid volume deficit (FVD)
                                                                                                                                        • DEHYDRATION
                                                                                                                                        • علل کاهش حجم خارج سلولی
                                                                                                                                        • Signs of Hypovolemia
                                                                                                                                        • Clinical Diagnosis of Hypovolemia
                                                                                                                                        • Signs of Hypervolemia
                                                                                                                                        • Management of Hypervolemia
                                                                                                                                        • Fluid Management
                                                                                                                                        • Electrolyte physiology
                                                                                                                                        • Sodium physiology
                                                                                                                                        • Osmotic Pressure
                                                                                                                                        • Concentration
                                                                                                                                        • Hypernatremia
                                                                                                                                        • - Hypernatremia
                                                                                                                                        • Slide 67
                                                                                                                                        • Slide 68
                                                                                                                                        • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                        • Treatment
                                                                                                                                        • Water deficit (L)= times TBW
                                                                                                                                        • The rate of fluid administration
                                                                                                                                        • Hyponatremia Nalt135mEqL
                                                                                                                                        • Slide 74
                                                                                                                                        • Sodium depletion
                                                                                                                                        • Sodium dilution
                                                                                                                                        • Sign and symptoms
                                                                                                                                        • Slide 78
                                                                                                                                        • Treatment
                                                                                                                                        • Slide 80
                                                                                                                                        • Slide 81
                                                                                                                                        • Dose
                                                                                                                                        • Potassium abnormalities
                                                                                                                                        • Hyperkalemia
                                                                                                                                        • Clinical manifestation of hyperkalemia
                                                                                                                                        • Slide 86
                                                                                                                                        • Slide 87
                                                                                                                                        • Hypokalemia
                                                                                                                                        • Potassium changes associated with alkalosis
                                                                                                                                        • Slide 90
                                                                                                                                        • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                        • Slide 92
                                                                                                                                        • Calcium
                                                                                                                                        • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                        • علائم هیپوکلسمی
                                                                                                                                        • Slide 96
                                                                                                                                        • Slide 97
                                                                                                                                        • Slide 98
                                                                                                                                        • Slide 99
                                                                                                                                        • سایرعلائم
                                                                                                                                        • درمان
                                                                                                                                        • هيپركلسمي Cagt55meql
                                                                                                                                        • علائم
                                                                                                                                        • علائم قلبی
                                                                                                                                        • Slide 105
                                                                                                                                        • Magnesium Abnormalities
                                                                                                                                        • منیزیوم
                                                                                                                                        • Hypermagnesemia
                                                                                                                                        • Clinical manifestation hypermanesemia
                                                                                                                                        • Slide 110
                                                                                                                                        • Slide 111
                                                                                                                                        • Hypomagnesemia
                                                                                                                                        • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                        • Slide 114
                                                                                                                                        • Message for Today
                                                                                                                                        • Slide 116

                                                                                                                                          Treatment

                                                                                                                                          Normal saline in hypovolemic patients

                                                                                                                                          Hypotonic fluid (Dw 5 DW 5 in frac14 or frac12 normal

                                                                                                                                          saline or entral water)

                                                                                                                                          Water deficit (L)= times TBW

                                                                                                                                          The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                                                          Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                                                          Serum sodium-140

                                                                                                                                          140

                                                                                                                                          The rate of fluid administration

                                                                                                                                          1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                                                          2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                                                          Hyponatremia Nalt135mEqL

                                                                                                                                          Causes

                                                                                                                                          1 Sodium depletion

                                                                                                                                          2 Sodium dilution

                                                                                                                                          bull Incidence = 45

                                                                                                                                          bull After surgery=1

                                                                                                                                          bull Mortality = 2 times normal

                                                                                                                                          Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                                                          volume deficit

                                                                                                                                          Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                                          Sign and symptoms

                                                                                                                                          bull CNS symptom when Nalt123 meql

                                                                                                                                          bull Cardiac symptom when Nalt100 meql

                                                                                                                                          For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                                          Body System Hyponatremia

                                                                                                                                          central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                                          reflexes seizures coma increased intracranial pressure

                                                                                                                                          Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                                          Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                                          Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                                          intracranial pressure

                                                                                                                                          Tissue Lacrimation salivation

                                                                                                                                          Renal Oliguria

                                                                                                                                          Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                                          Treatment

                                                                                                                                          1=Depend on ECF

                                                                                                                                          2=CNS sign

                                                                                                                                          Treatment

                                                                                                                                          1 Asymptomatic increase the sodium level by no more than

                                                                                                                                          05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                                          2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                                          more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                                          meqL or neurologic symptoms are improved

                                                                                                                                          Rapid correction of hyponatremia

                                                                                                                                          Pontine myelinolysis

                                                                                                                                          Seizures weaknessparesis akinetic

                                                                                                                                          movements unresponsiveness

                                                                                                                                          Permanent brain damage

                                                                                                                                          Death

                                                                                                                                          Dose

                                                                                                                                          Na deficit meq =(140- Na meql) TBW

                                                                                                                                          باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                                          شود اصالح آهسته سپس

                                                                                                                                          Potassium abnormalities

                                                                                                                                          bull The average dietary intake of potassium 50-100meqd

                                                                                                                                          bull The average renal excretion of potassium 10-700 meqd

                                                                                                                                          - 2 of the total body potassium in ECF (45meqL)

                                                                                                                                          - Factors that influence serum potassium

                                                                                                                                          1 Surgical stress

                                                                                                                                          2 Injury

                                                                                                                                          3 Acidosis

                                                                                                                                          4 Tissue catabolism

                                                                                                                                          Hyperkalemia

                                                                                                                                          The normal range of serum potassium 35-5 meqL

                                                                                                                                          Etiology of Hyperkalemia

                                                                                                                                          Increased intake Potassium supplementation

                                                                                                                                          Blood transfusions

                                                                                                                                          Endogenous loaddestruction

                                                                                                                                          hemolysis rhabdomyolysis

                                                                                                                                          cruch injury gastrointestinal hemorrhage

                                                                                                                                          Increased release Acidosis

                                                                                                                                          Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                          Renal insufficiencyfailure

                                                                                                                                          Clinical manifestation of hyperkalemia

                                                                                                                                          System hyperkalemia

                                                                                                                                          Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                          Neuromuscular weakness paralysis respiratory failure

                                                                                                                                          Cardiovascular Arrhythmia arrest

                                                                                                                                          ECG changes Peaked T waves (early change)

                                                                                                                                          Flattened P wave

                                                                                                                                          Prolonged PR interval (first-degree block)

                                                                                                                                          Widened QRS complex

                                                                                                                                          Sine wave formation

                                                                                                                                          Ventricular fibrillation

                                                                                                                                          Treatment

                                                                                                                                          Treatment of symptomatic hyperkalemia

                                                                                                                                          Potassium removal Kayexalate

                                                                                                                                          Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                          Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                          Dialysis

                                                                                                                                          Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                          Bicarbonate 1 vial intravenous

                                                                                                                                          Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                          HypokalemiaEtiology

                                                                                                                                          inadequate intake

                                                                                                                                          Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                          total parenteral nutrition

                                                                                                                                          Excessive potassium excretion

                                                                                                                                          Hyperaldosteronism

                                                                                                                                          Medications

                                                                                                                                          Gastrointestinal losses

                                                                                                                                          Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                          Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                          nasogastric output)

                                                                                                                                          Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                          Potassium changes associated with alkalosis

                                                                                                                                          Potassium decrease by 03 meqL for every 01

                                                                                                                                          increase in PH above normal

                                                                                                                                          Magnesium Depletion

                                                                                                                                          (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                          Renal potassium wastage

                                                                                                                                          Hypokalemia

                                                                                                                                          Magnesium Depletion

                                                                                                                                          (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                          Renal potassium wastage

                                                                                                                                          Hypokalemia

                                                                                                                                          Clinical Manifestation of Abnormalities in potassium

                                                                                                                                          System hypokalemia

                                                                                                                                          Gastrointestinal Ileus constipation

                                                                                                                                          Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                          paralysis

                                                                                                                                          Cardiovascular Arrest

                                                                                                                                          ECG changes U-waves

                                                                                                                                          T-wave flattening

                                                                                                                                          ST-segment changes

                                                                                                                                          Arrhythmias

                                                                                                                                          Treatment

                                                                                                                                          Potassium

                                                                                                                                          Serum potassium level lt40 mEqL

                                                                                                                                          Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                          times 1 doses

                                                                                                                                          Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                          Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                          Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                          asymptomatic replace as per above protocol

                                                                                                                                          Electrolyte Replacement Therapy Protocol

                                                                                                                                          bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                          bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                          Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                          ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                          عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                          صاف 2 عضالت انقباض

                                                                                                                                          هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                          انعقاد 4

                                                                                                                                          یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                          عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                          ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                          میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                          ( شود می پیوند شده

                                                                                                                                          هیپوکلسمی عالئم

                                                                                                                                          رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                          سایرعالئم

                                                                                                                                          قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                          درمان

                                                                                                                                          ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                          Cagt55meql هيپركلسمي

                                                                                                                                          هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                          عالئم

                                                                                                                                          bullGI

                                                                                                                                          bullCardiovascular bullRenal (polyuria)

                                                                                                                                          bullCNS

                                                                                                                                          قلبی عالئم

                                                                                                                                          bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                          QRS شدن )Q-Tوكوتاه

                                                                                                                                          درمان

                                                                                                                                          ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                          الزیکس2

                                                                                                                                          تونین 3 کلسی

                                                                                                                                          کورتون4

                                                                                                                                          دیالیز5

                                                                                                                                          Magnesium Abnormalities

                                                                                                                                          Normal dietary intake 20meq (240mg)

                                                                                                                                          Excretion in both the feces and urine

                                                                                                                                          Normal serum level 19-25 mgdL

                                                                                                                                          منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                          تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                          bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                          Hypermagnesemia

                                                                                                                                          Etiology

                                                                                                                                          1 Impaired renal function

                                                                                                                                          2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                          Clinical manifestation hypermanesemia

                                                                                                                                          System hypermanesemia

                                                                                                                                          Gastrointestinal Nauseavomiting

                                                                                                                                          Neuromuscular weakness lethargy Decreased

                                                                                                                                          reflexes

                                                                                                                                          Cardiovascular Hypotension arrest

                                                                                                                                          ECG changes Increased PR interval

                                                                                                                                          Widened QRS complex

                                                                                                                                          Elevated T waves

                                                                                                                                          Treatment

                                                                                                                                          1 Withhold exogenous sources of magnesium

                                                                                                                                          2 Correct volume deficit

                                                                                                                                          3 Correct acidosis if present

                                                                                                                                          4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                          5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                          عالئم

                                                                                                                                          bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                          meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                          meqL

                                                                                                                                          Hypomagnesemia

                                                                                                                                          Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                          homeostasis

                                                                                                                                          Etiology

                                                                                                                                          1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                          inadequate supplementation of magnesium)

                                                                                                                                          2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                          3 GI losses (diarrhea)

                                                                                                                                          4 Malabsorption

                                                                                                                                          5 Acute pancreatitis

                                                                                                                                          6 Diabetic ketoacidosis

                                                                                                                                          7 Primary aldosteronism

                                                                                                                                          Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                          1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                          2 Delirium and seizures in severe deficiency

                                                                                                                                          3 ECG changes Prolonged QT and PR interval

                                                                                                                                          ST-segment depression

                                                                                                                                          Flattening or inversion of P waves

                                                                                                                                          Torsades de pointes

                                                                                                                                          Arrhythmia

                                                                                                                                          Treatment

                                                                                                                                          1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                          2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                          Message for Today

                                                                                                                                          ICF

                                                                                                                                          Interstitial

                                                                                                                                          Pla

                                                                                                                                          sma

                                                                                                                                          5 Dex

                                                                                                                                          bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                          • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                          • Slide 2
                                                                                                                                          • Slide 3
                                                                                                                                          • Slide 4
                                                                                                                                          • Total Body Water
                                                                                                                                          • Body Fluid Compartments
                                                                                                                                          • Total body water (TBW)
                                                                                                                                          • Body compartment fluid
                                                                                                                                          • Example men with 70kg
                                                                                                                                          • Fluid compartments
                                                                                                                                          • Slide 11
                                                                                                                                          • Slide 12
                                                                                                                                          • Slide 13
                                                                                                                                          • Slide 14
                                                                                                                                          • Slide 15
                                                                                                                                          • Colloid osmotic pressure
                                                                                                                                          • Slide 17
                                                                                                                                          • Slide 18
                                                                                                                                          • Slide 19
                                                                                                                                          • Cell Membrane
                                                                                                                                          • Slide 21
                                                                                                                                          • Slide 22
                                                                                                                                          • Slide 23
                                                                                                                                          • Slide 24
                                                                                                                                          • Slide 25
                                                                                                                                          • Composition of Fluid Compartments
                                                                                                                                          • Composition of Body Fluids
                                                                                                                                          • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                          • Reasons for fluid therapy
                                                                                                                                          • ارزیابی حجم مایع داخل عروقی
                                                                                                                                          • محلولهای وریدی
                                                                                                                                          • Fluids
                                                                                                                                          • Slide 33
                                                                                                                                          • Slide 34
                                                                                                                                          • Slide 35
                                                                                                                                          • Crystalloids
                                                                                                                                          • Colloid Solutions
                                                                                                                                          • رینگر لاکتات
                                                                                                                                          • 09Nacl
                                                                                                                                          • Postoperative (maintenance)
                                                                                                                                          • Slide 41
                                                                                                                                          • Preexisting fluid deficits
                                                                                                                                          • Maintenance requirements
                                                                                                                                          • Surgical fluid losses
                                                                                                                                          • Third space loss
                                                                                                                                          • Crystalloid solution
                                                                                                                                          • Colloids
                                                                                                                                          • Complications
                                                                                                                                          • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                          • Colloid versus crystalloid solutions
                                                                                                                                          • Transfusion consideration
                                                                                                                                          • اختلال در حجم مایعات بدن
                                                                                                                                          • Fluid volume deficit (FVD)
                                                                                                                                          • DEHYDRATION
                                                                                                                                          • علل کاهش حجم خارج سلولی
                                                                                                                                          • Signs of Hypovolemia
                                                                                                                                          • Clinical Diagnosis of Hypovolemia
                                                                                                                                          • Signs of Hypervolemia
                                                                                                                                          • Management of Hypervolemia
                                                                                                                                          • Fluid Management
                                                                                                                                          • Electrolyte physiology
                                                                                                                                          • Sodium physiology
                                                                                                                                          • Osmotic Pressure
                                                                                                                                          • Concentration
                                                                                                                                          • Hypernatremia
                                                                                                                                          • - Hypernatremia
                                                                                                                                          • Slide 67
                                                                                                                                          • Slide 68
                                                                                                                                          • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                          • Treatment
                                                                                                                                          • Water deficit (L)= times TBW
                                                                                                                                          • The rate of fluid administration
                                                                                                                                          • Hyponatremia Nalt135mEqL
                                                                                                                                          • Slide 74
                                                                                                                                          • Sodium depletion
                                                                                                                                          • Sodium dilution
                                                                                                                                          • Sign and symptoms
                                                                                                                                          • Slide 78
                                                                                                                                          • Treatment
                                                                                                                                          • Slide 80
                                                                                                                                          • Slide 81
                                                                                                                                          • Dose
                                                                                                                                          • Potassium abnormalities
                                                                                                                                          • Hyperkalemia
                                                                                                                                          • Clinical manifestation of hyperkalemia
                                                                                                                                          • Slide 86
                                                                                                                                          • Slide 87
                                                                                                                                          • Hypokalemia
                                                                                                                                          • Potassium changes associated with alkalosis
                                                                                                                                          • Slide 90
                                                                                                                                          • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                          • Slide 92
                                                                                                                                          • Calcium
                                                                                                                                          • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                          • علائم هیپوکلسمی
                                                                                                                                          • Slide 96
                                                                                                                                          • Slide 97
                                                                                                                                          • Slide 98
                                                                                                                                          • Slide 99
                                                                                                                                          • سایرعلائم
                                                                                                                                          • درمان
                                                                                                                                          • هيپركلسمي Cagt55meql
                                                                                                                                          • علائم
                                                                                                                                          • علائم قلبی
                                                                                                                                          • Slide 105
                                                                                                                                          • Magnesium Abnormalities
                                                                                                                                          • منیزیوم
                                                                                                                                          • Hypermagnesemia
                                                                                                                                          • Clinical manifestation hypermanesemia
                                                                                                                                          • Slide 110
                                                                                                                                          • Slide 111
                                                                                                                                          • Hypomagnesemia
                                                                                                                                          • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                          • Slide 114
                                                                                                                                          • Message for Today
                                                                                                                                          • Slide 116

                                                                                                                                            Water deficit (L)= times TBW

                                                                                                                                            The formula used to estimate the amount of water required to correct hypernatremia

                                                                                                                                            Estimate TBW as 55 of lean body mass in men and 45 in women

                                                                                                                                            Serum sodium-140

                                                                                                                                            140

                                                                                                                                            The rate of fluid administration

                                                                                                                                            1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                                                            2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                                                            Hyponatremia Nalt135mEqL

                                                                                                                                            Causes

                                                                                                                                            1 Sodium depletion

                                                                                                                                            2 Sodium dilution

                                                                                                                                            bull Incidence = 45

                                                                                                                                            bull After surgery=1

                                                                                                                                            bull Mortality = 2 times normal

                                                                                                                                            Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                                                            volume deficit

                                                                                                                                            Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                                            Sign and symptoms

                                                                                                                                            bull CNS symptom when Nalt123 meql

                                                                                                                                            bull Cardiac symptom when Nalt100 meql

                                                                                                                                            For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                                            Body System Hyponatremia

                                                                                                                                            central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                                            reflexes seizures coma increased intracranial pressure

                                                                                                                                            Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                                            Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                                            Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                                            intracranial pressure

                                                                                                                                            Tissue Lacrimation salivation

                                                                                                                                            Renal Oliguria

                                                                                                                                            Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                                            Treatment

                                                                                                                                            1=Depend on ECF

                                                                                                                                            2=CNS sign

                                                                                                                                            Treatment

                                                                                                                                            1 Asymptomatic increase the sodium level by no more than

                                                                                                                                            05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                                            2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                                            more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                                            meqL or neurologic symptoms are improved

                                                                                                                                            Rapid correction of hyponatremia

                                                                                                                                            Pontine myelinolysis

                                                                                                                                            Seizures weaknessparesis akinetic

                                                                                                                                            movements unresponsiveness

                                                                                                                                            Permanent brain damage

                                                                                                                                            Death

                                                                                                                                            Dose

                                                                                                                                            Na deficit meq =(140- Na meql) TBW

                                                                                                                                            باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                                            شود اصالح آهسته سپس

                                                                                                                                            Potassium abnormalities

                                                                                                                                            bull The average dietary intake of potassium 50-100meqd

                                                                                                                                            bull The average renal excretion of potassium 10-700 meqd

                                                                                                                                            - 2 of the total body potassium in ECF (45meqL)

                                                                                                                                            - Factors that influence serum potassium

                                                                                                                                            1 Surgical stress

                                                                                                                                            2 Injury

                                                                                                                                            3 Acidosis

                                                                                                                                            4 Tissue catabolism

                                                                                                                                            Hyperkalemia

                                                                                                                                            The normal range of serum potassium 35-5 meqL

                                                                                                                                            Etiology of Hyperkalemia

                                                                                                                                            Increased intake Potassium supplementation

                                                                                                                                            Blood transfusions

                                                                                                                                            Endogenous loaddestruction

                                                                                                                                            hemolysis rhabdomyolysis

                                                                                                                                            cruch injury gastrointestinal hemorrhage

                                                                                                                                            Increased release Acidosis

                                                                                                                                            Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                            Renal insufficiencyfailure

                                                                                                                                            Clinical manifestation of hyperkalemia

                                                                                                                                            System hyperkalemia

                                                                                                                                            Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                            Neuromuscular weakness paralysis respiratory failure

                                                                                                                                            Cardiovascular Arrhythmia arrest

                                                                                                                                            ECG changes Peaked T waves (early change)

                                                                                                                                            Flattened P wave

                                                                                                                                            Prolonged PR interval (first-degree block)

                                                                                                                                            Widened QRS complex

                                                                                                                                            Sine wave formation

                                                                                                                                            Ventricular fibrillation

                                                                                                                                            Treatment

                                                                                                                                            Treatment of symptomatic hyperkalemia

                                                                                                                                            Potassium removal Kayexalate

                                                                                                                                            Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                            Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                            Dialysis

                                                                                                                                            Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                            Bicarbonate 1 vial intravenous

                                                                                                                                            Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                            HypokalemiaEtiology

                                                                                                                                            inadequate intake

                                                                                                                                            Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                            total parenteral nutrition

                                                                                                                                            Excessive potassium excretion

                                                                                                                                            Hyperaldosteronism

                                                                                                                                            Medications

                                                                                                                                            Gastrointestinal losses

                                                                                                                                            Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                            Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                            nasogastric output)

                                                                                                                                            Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                            Potassium changes associated with alkalosis

                                                                                                                                            Potassium decrease by 03 meqL for every 01

                                                                                                                                            increase in PH above normal

                                                                                                                                            Magnesium Depletion

                                                                                                                                            (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                            Renal potassium wastage

                                                                                                                                            Hypokalemia

                                                                                                                                            Magnesium Depletion

                                                                                                                                            (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                            Renal potassium wastage

                                                                                                                                            Hypokalemia

                                                                                                                                            Clinical Manifestation of Abnormalities in potassium

                                                                                                                                            System hypokalemia

                                                                                                                                            Gastrointestinal Ileus constipation

                                                                                                                                            Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                            paralysis

                                                                                                                                            Cardiovascular Arrest

                                                                                                                                            ECG changes U-waves

                                                                                                                                            T-wave flattening

                                                                                                                                            ST-segment changes

                                                                                                                                            Arrhythmias

                                                                                                                                            Treatment

                                                                                                                                            Potassium

                                                                                                                                            Serum potassium level lt40 mEqL

                                                                                                                                            Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                            times 1 doses

                                                                                                                                            Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                            Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                            Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                            asymptomatic replace as per above protocol

                                                                                                                                            Electrolyte Replacement Therapy Protocol

                                                                                                                                            bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                            bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                            Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                            ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                            عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                            صاف 2 عضالت انقباض

                                                                                                                                            هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                            انعقاد 4

                                                                                                                                            یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                            عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                            ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                            میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                            ( شود می پیوند شده

                                                                                                                                            هیپوکلسمی عالئم

                                                                                                                                            رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                            سایرعالئم

                                                                                                                                            قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                            درمان

                                                                                                                                            ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                            Cagt55meql هيپركلسمي

                                                                                                                                            هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                            عالئم

                                                                                                                                            bullGI

                                                                                                                                            bullCardiovascular bullRenal (polyuria)

                                                                                                                                            bullCNS

                                                                                                                                            قلبی عالئم

                                                                                                                                            bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                            QRS شدن )Q-Tوكوتاه

                                                                                                                                            درمان

                                                                                                                                            ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                            الزیکس2

                                                                                                                                            تونین 3 کلسی

                                                                                                                                            کورتون4

                                                                                                                                            دیالیز5

                                                                                                                                            Magnesium Abnormalities

                                                                                                                                            Normal dietary intake 20meq (240mg)

                                                                                                                                            Excretion in both the feces and urine

                                                                                                                                            Normal serum level 19-25 mgdL

                                                                                                                                            منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                            تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                            bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                            Hypermagnesemia

                                                                                                                                            Etiology

                                                                                                                                            1 Impaired renal function

                                                                                                                                            2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                            Clinical manifestation hypermanesemia

                                                                                                                                            System hypermanesemia

                                                                                                                                            Gastrointestinal Nauseavomiting

                                                                                                                                            Neuromuscular weakness lethargy Decreased

                                                                                                                                            reflexes

                                                                                                                                            Cardiovascular Hypotension arrest

                                                                                                                                            ECG changes Increased PR interval

                                                                                                                                            Widened QRS complex

                                                                                                                                            Elevated T waves

                                                                                                                                            Treatment

                                                                                                                                            1 Withhold exogenous sources of magnesium

                                                                                                                                            2 Correct volume deficit

                                                                                                                                            3 Correct acidosis if present

                                                                                                                                            4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                            5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                            عالئم

                                                                                                                                            bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                            meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                            meqL

                                                                                                                                            Hypomagnesemia

                                                                                                                                            Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                            homeostasis

                                                                                                                                            Etiology

                                                                                                                                            1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                            inadequate supplementation of magnesium)

                                                                                                                                            2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                            3 GI losses (diarrhea)

                                                                                                                                            4 Malabsorption

                                                                                                                                            5 Acute pancreatitis

                                                                                                                                            6 Diabetic ketoacidosis

                                                                                                                                            7 Primary aldosteronism

                                                                                                                                            Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                            1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                            2 Delirium and seizures in severe deficiency

                                                                                                                                            3 ECG changes Prolonged QT and PR interval

                                                                                                                                            ST-segment depression

                                                                                                                                            Flattening or inversion of P waves

                                                                                                                                            Torsades de pointes

                                                                                                                                            Arrhythmia

                                                                                                                                            Treatment

                                                                                                                                            1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                            2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                            Message for Today

                                                                                                                                            ICF

                                                                                                                                            Interstitial

                                                                                                                                            Pla

                                                                                                                                            sma

                                                                                                                                            5 Dex

                                                                                                                                            bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                            • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                            • Slide 2
                                                                                                                                            • Slide 3
                                                                                                                                            • Slide 4
                                                                                                                                            • Total Body Water
                                                                                                                                            • Body Fluid Compartments
                                                                                                                                            • Total body water (TBW)
                                                                                                                                            • Body compartment fluid
                                                                                                                                            • Example men with 70kg
                                                                                                                                            • Fluid compartments
                                                                                                                                            • Slide 11
                                                                                                                                            • Slide 12
                                                                                                                                            • Slide 13
                                                                                                                                            • Slide 14
                                                                                                                                            • Slide 15
                                                                                                                                            • Colloid osmotic pressure
                                                                                                                                            • Slide 17
                                                                                                                                            • Slide 18
                                                                                                                                            • Slide 19
                                                                                                                                            • Cell Membrane
                                                                                                                                            • Slide 21
                                                                                                                                            • Slide 22
                                                                                                                                            • Slide 23
                                                                                                                                            • Slide 24
                                                                                                                                            • Slide 25
                                                                                                                                            • Composition of Fluid Compartments
                                                                                                                                            • Composition of Body Fluids
                                                                                                                                            • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                            • Reasons for fluid therapy
                                                                                                                                            • ارزیابی حجم مایع داخل عروقی
                                                                                                                                            • محلولهای وریدی
                                                                                                                                            • Fluids
                                                                                                                                            • Slide 33
                                                                                                                                            • Slide 34
                                                                                                                                            • Slide 35
                                                                                                                                            • Crystalloids
                                                                                                                                            • Colloid Solutions
                                                                                                                                            • رینگر لاکتات
                                                                                                                                            • 09Nacl
                                                                                                                                            • Postoperative (maintenance)
                                                                                                                                            • Slide 41
                                                                                                                                            • Preexisting fluid deficits
                                                                                                                                            • Maintenance requirements
                                                                                                                                            • Surgical fluid losses
                                                                                                                                            • Third space loss
                                                                                                                                            • Crystalloid solution
                                                                                                                                            • Colloids
                                                                                                                                            • Complications
                                                                                                                                            • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                            • Colloid versus crystalloid solutions
                                                                                                                                            • Transfusion consideration
                                                                                                                                            • اختلال در حجم مایعات بدن
                                                                                                                                            • Fluid volume deficit (FVD)
                                                                                                                                            • DEHYDRATION
                                                                                                                                            • علل کاهش حجم خارج سلولی
                                                                                                                                            • Signs of Hypovolemia
                                                                                                                                            • Clinical Diagnosis of Hypovolemia
                                                                                                                                            • Signs of Hypervolemia
                                                                                                                                            • Management of Hypervolemia
                                                                                                                                            • Fluid Management
                                                                                                                                            • Electrolyte physiology
                                                                                                                                            • Sodium physiology
                                                                                                                                            • Osmotic Pressure
                                                                                                                                            • Concentration
                                                                                                                                            • Hypernatremia
                                                                                                                                            • - Hypernatremia
                                                                                                                                            • Slide 67
                                                                                                                                            • Slide 68
                                                                                                                                            • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                            • Treatment
                                                                                                                                            • Water deficit (L)= times TBW
                                                                                                                                            • The rate of fluid administration
                                                                                                                                            • Hyponatremia Nalt135mEqL
                                                                                                                                            • Slide 74
                                                                                                                                            • Sodium depletion
                                                                                                                                            • Sodium dilution
                                                                                                                                            • Sign and symptoms
                                                                                                                                            • Slide 78
                                                                                                                                            • Treatment
                                                                                                                                            • Slide 80
                                                                                                                                            • Slide 81
                                                                                                                                            • Dose
                                                                                                                                            • Potassium abnormalities
                                                                                                                                            • Hyperkalemia
                                                                                                                                            • Clinical manifestation of hyperkalemia
                                                                                                                                            • Slide 86
                                                                                                                                            • Slide 87
                                                                                                                                            • Hypokalemia
                                                                                                                                            • Potassium changes associated with alkalosis
                                                                                                                                            • Slide 90
                                                                                                                                            • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                            • Slide 92
                                                                                                                                            • Calcium
                                                                                                                                            • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                            • علائم هیپوکلسمی
                                                                                                                                            • Slide 96
                                                                                                                                            • Slide 97
                                                                                                                                            • Slide 98
                                                                                                                                            • Slide 99
                                                                                                                                            • سایرعلائم
                                                                                                                                            • درمان
                                                                                                                                            • هيپركلسمي Cagt55meql
                                                                                                                                            • علائم
                                                                                                                                            • علائم قلبی
                                                                                                                                            • Slide 105
                                                                                                                                            • Magnesium Abnormalities
                                                                                                                                            • منیزیوم
                                                                                                                                            • Hypermagnesemia
                                                                                                                                            • Clinical manifestation hypermanesemia
                                                                                                                                            • Slide 110
                                                                                                                                            • Slide 111
                                                                                                                                            • Hypomagnesemia
                                                                                                                                            • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                            • Slide 114
                                                                                                                                            • Message for Today
                                                                                                                                            • Slide 116

                                                                                                                                              The rate of fluid administration

                                                                                                                                              1 Acute hypernatremia a decrease in serum sodium of no more than 1meqh and 12meqd

                                                                                                                                              2 Chronic hypernatremia a decrease in serum sodium of no more than 07meqLh

                                                                                                                                              Hyponatremia Nalt135mEqL

                                                                                                                                              Causes

                                                                                                                                              1 Sodium depletion

                                                                                                                                              2 Sodium dilution

                                                                                                                                              bull Incidence = 45

                                                                                                                                              bull After surgery=1

                                                                                                                                              bull Mortality = 2 times normal

                                                                                                                                              Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                                                              volume deficit

                                                                                                                                              Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                                              Sign and symptoms

                                                                                                                                              bull CNS symptom when Nalt123 meql

                                                                                                                                              bull Cardiac symptom when Nalt100 meql

                                                                                                                                              For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                                              Body System Hyponatremia

                                                                                                                                              central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                                              reflexes seizures coma increased intracranial pressure

                                                                                                                                              Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                                              Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                                              Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                                              intracranial pressure

                                                                                                                                              Tissue Lacrimation salivation

                                                                                                                                              Renal Oliguria

                                                                                                                                              Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                                              Treatment

                                                                                                                                              1=Depend on ECF

                                                                                                                                              2=CNS sign

                                                                                                                                              Treatment

                                                                                                                                              1 Asymptomatic increase the sodium level by no more than

                                                                                                                                              05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                                              2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                                              more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                                              meqL or neurologic symptoms are improved

                                                                                                                                              Rapid correction of hyponatremia

                                                                                                                                              Pontine myelinolysis

                                                                                                                                              Seizures weaknessparesis akinetic

                                                                                                                                              movements unresponsiveness

                                                                                                                                              Permanent brain damage

                                                                                                                                              Death

                                                                                                                                              Dose

                                                                                                                                              Na deficit meq =(140- Na meql) TBW

                                                                                                                                              باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                                              شود اصالح آهسته سپس

                                                                                                                                              Potassium abnormalities

                                                                                                                                              bull The average dietary intake of potassium 50-100meqd

                                                                                                                                              bull The average renal excretion of potassium 10-700 meqd

                                                                                                                                              - 2 of the total body potassium in ECF (45meqL)

                                                                                                                                              - Factors that influence serum potassium

                                                                                                                                              1 Surgical stress

                                                                                                                                              2 Injury

                                                                                                                                              3 Acidosis

                                                                                                                                              4 Tissue catabolism

                                                                                                                                              Hyperkalemia

                                                                                                                                              The normal range of serum potassium 35-5 meqL

                                                                                                                                              Etiology of Hyperkalemia

                                                                                                                                              Increased intake Potassium supplementation

                                                                                                                                              Blood transfusions

                                                                                                                                              Endogenous loaddestruction

                                                                                                                                              hemolysis rhabdomyolysis

                                                                                                                                              cruch injury gastrointestinal hemorrhage

                                                                                                                                              Increased release Acidosis

                                                                                                                                              Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                              Renal insufficiencyfailure

                                                                                                                                              Clinical manifestation of hyperkalemia

                                                                                                                                              System hyperkalemia

                                                                                                                                              Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                              Neuromuscular weakness paralysis respiratory failure

                                                                                                                                              Cardiovascular Arrhythmia arrest

                                                                                                                                              ECG changes Peaked T waves (early change)

                                                                                                                                              Flattened P wave

                                                                                                                                              Prolonged PR interval (first-degree block)

                                                                                                                                              Widened QRS complex

                                                                                                                                              Sine wave formation

                                                                                                                                              Ventricular fibrillation

                                                                                                                                              Treatment

                                                                                                                                              Treatment of symptomatic hyperkalemia

                                                                                                                                              Potassium removal Kayexalate

                                                                                                                                              Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                              Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                              Dialysis

                                                                                                                                              Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                              Bicarbonate 1 vial intravenous

                                                                                                                                              Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                              HypokalemiaEtiology

                                                                                                                                              inadequate intake

                                                                                                                                              Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                              total parenteral nutrition

                                                                                                                                              Excessive potassium excretion

                                                                                                                                              Hyperaldosteronism

                                                                                                                                              Medications

                                                                                                                                              Gastrointestinal losses

                                                                                                                                              Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                              Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                              nasogastric output)

                                                                                                                                              Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                              Potassium changes associated with alkalosis

                                                                                                                                              Potassium decrease by 03 meqL for every 01

                                                                                                                                              increase in PH above normal

                                                                                                                                              Magnesium Depletion

                                                                                                                                              (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                              Renal potassium wastage

                                                                                                                                              Hypokalemia

                                                                                                                                              Magnesium Depletion

                                                                                                                                              (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                              Renal potassium wastage

                                                                                                                                              Hypokalemia

                                                                                                                                              Clinical Manifestation of Abnormalities in potassium

                                                                                                                                              System hypokalemia

                                                                                                                                              Gastrointestinal Ileus constipation

                                                                                                                                              Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                              paralysis

                                                                                                                                              Cardiovascular Arrest

                                                                                                                                              ECG changes U-waves

                                                                                                                                              T-wave flattening

                                                                                                                                              ST-segment changes

                                                                                                                                              Arrhythmias

                                                                                                                                              Treatment

                                                                                                                                              Potassium

                                                                                                                                              Serum potassium level lt40 mEqL

                                                                                                                                              Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                              times 1 doses

                                                                                                                                              Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                              Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                              Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                              asymptomatic replace as per above protocol

                                                                                                                                              Electrolyte Replacement Therapy Protocol

                                                                                                                                              bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                              bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                              Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                              ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                              عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                              صاف 2 عضالت انقباض

                                                                                                                                              هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                              انعقاد 4

                                                                                                                                              یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                              عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                              ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                              میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                              ( شود می پیوند شده

                                                                                                                                              هیپوکلسمی عالئم

                                                                                                                                              رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                              سایرعالئم

                                                                                                                                              قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                              درمان

                                                                                                                                              ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                              Cagt55meql هيپركلسمي

                                                                                                                                              هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                              عالئم

                                                                                                                                              bullGI

                                                                                                                                              bullCardiovascular bullRenal (polyuria)

                                                                                                                                              bullCNS

                                                                                                                                              قلبی عالئم

                                                                                                                                              bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                              QRS شدن )Q-Tوكوتاه

                                                                                                                                              درمان

                                                                                                                                              ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                              الزیکس2

                                                                                                                                              تونین 3 کلسی

                                                                                                                                              کورتون4

                                                                                                                                              دیالیز5

                                                                                                                                              Magnesium Abnormalities

                                                                                                                                              Normal dietary intake 20meq (240mg)

                                                                                                                                              Excretion in both the feces and urine

                                                                                                                                              Normal serum level 19-25 mgdL

                                                                                                                                              منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                              تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                              bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                              Hypermagnesemia

                                                                                                                                              Etiology

                                                                                                                                              1 Impaired renal function

                                                                                                                                              2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                              Clinical manifestation hypermanesemia

                                                                                                                                              System hypermanesemia

                                                                                                                                              Gastrointestinal Nauseavomiting

                                                                                                                                              Neuromuscular weakness lethargy Decreased

                                                                                                                                              reflexes

                                                                                                                                              Cardiovascular Hypotension arrest

                                                                                                                                              ECG changes Increased PR interval

                                                                                                                                              Widened QRS complex

                                                                                                                                              Elevated T waves

                                                                                                                                              Treatment

                                                                                                                                              1 Withhold exogenous sources of magnesium

                                                                                                                                              2 Correct volume deficit

                                                                                                                                              3 Correct acidosis if present

                                                                                                                                              4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                              5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                              عالئم

                                                                                                                                              bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                              meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                              meqL

                                                                                                                                              Hypomagnesemia

                                                                                                                                              Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                              homeostasis

                                                                                                                                              Etiology

                                                                                                                                              1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                              inadequate supplementation of magnesium)

                                                                                                                                              2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                              3 GI losses (diarrhea)

                                                                                                                                              4 Malabsorption

                                                                                                                                              5 Acute pancreatitis

                                                                                                                                              6 Diabetic ketoacidosis

                                                                                                                                              7 Primary aldosteronism

                                                                                                                                              Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                              1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                              2 Delirium and seizures in severe deficiency

                                                                                                                                              3 ECG changes Prolonged QT and PR interval

                                                                                                                                              ST-segment depression

                                                                                                                                              Flattening or inversion of P waves

                                                                                                                                              Torsades de pointes

                                                                                                                                              Arrhythmia

                                                                                                                                              Treatment

                                                                                                                                              1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                              2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                              Message for Today

                                                                                                                                              ICF

                                                                                                                                              Interstitial

                                                                                                                                              Pla

                                                                                                                                              sma

                                                                                                                                              5 Dex

                                                                                                                                              bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                              • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                              • Slide 2
                                                                                                                                              • Slide 3
                                                                                                                                              • Slide 4
                                                                                                                                              • Total Body Water
                                                                                                                                              • Body Fluid Compartments
                                                                                                                                              • Total body water (TBW)
                                                                                                                                              • Body compartment fluid
                                                                                                                                              • Example men with 70kg
                                                                                                                                              • Fluid compartments
                                                                                                                                              • Slide 11
                                                                                                                                              • Slide 12
                                                                                                                                              • Slide 13
                                                                                                                                              • Slide 14
                                                                                                                                              • Slide 15
                                                                                                                                              • Colloid osmotic pressure
                                                                                                                                              • Slide 17
                                                                                                                                              • Slide 18
                                                                                                                                              • Slide 19
                                                                                                                                              • Cell Membrane
                                                                                                                                              • Slide 21
                                                                                                                                              • Slide 22
                                                                                                                                              • Slide 23
                                                                                                                                              • Slide 24
                                                                                                                                              • Slide 25
                                                                                                                                              • Composition of Fluid Compartments
                                                                                                                                              • Composition of Body Fluids
                                                                                                                                              • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                              • Reasons for fluid therapy
                                                                                                                                              • ارزیابی حجم مایع داخل عروقی
                                                                                                                                              • محلولهای وریدی
                                                                                                                                              • Fluids
                                                                                                                                              • Slide 33
                                                                                                                                              • Slide 34
                                                                                                                                              • Slide 35
                                                                                                                                              • Crystalloids
                                                                                                                                              • Colloid Solutions
                                                                                                                                              • رینگر لاکتات
                                                                                                                                              • 09Nacl
                                                                                                                                              • Postoperative (maintenance)
                                                                                                                                              • Slide 41
                                                                                                                                              • Preexisting fluid deficits
                                                                                                                                              • Maintenance requirements
                                                                                                                                              • Surgical fluid losses
                                                                                                                                              • Third space loss
                                                                                                                                              • Crystalloid solution
                                                                                                                                              • Colloids
                                                                                                                                              • Complications
                                                                                                                                              • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                              • Colloid versus crystalloid solutions
                                                                                                                                              • Transfusion consideration
                                                                                                                                              • اختلال در حجم مایعات بدن
                                                                                                                                              • Fluid volume deficit (FVD)
                                                                                                                                              • DEHYDRATION
                                                                                                                                              • علل کاهش حجم خارج سلولی
                                                                                                                                              • Signs of Hypovolemia
                                                                                                                                              • Clinical Diagnosis of Hypovolemia
                                                                                                                                              • Signs of Hypervolemia
                                                                                                                                              • Management of Hypervolemia
                                                                                                                                              • Fluid Management
                                                                                                                                              • Electrolyte physiology
                                                                                                                                              • Sodium physiology
                                                                                                                                              • Osmotic Pressure
                                                                                                                                              • Concentration
                                                                                                                                              • Hypernatremia
                                                                                                                                              • - Hypernatremia
                                                                                                                                              • Slide 67
                                                                                                                                              • Slide 68
                                                                                                                                              • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                              • Treatment
                                                                                                                                              • Water deficit (L)= times TBW
                                                                                                                                              • The rate of fluid administration
                                                                                                                                              • Hyponatremia Nalt135mEqL
                                                                                                                                              • Slide 74
                                                                                                                                              • Sodium depletion
                                                                                                                                              • Sodium dilution
                                                                                                                                              • Sign and symptoms
                                                                                                                                              • Slide 78
                                                                                                                                              • Treatment
                                                                                                                                              • Slide 80
                                                                                                                                              • Slide 81
                                                                                                                                              • Dose
                                                                                                                                              • Potassium abnormalities
                                                                                                                                              • Hyperkalemia
                                                                                                                                              • Clinical manifestation of hyperkalemia
                                                                                                                                              • Slide 86
                                                                                                                                              • Slide 87
                                                                                                                                              • Hypokalemia
                                                                                                                                              • Potassium changes associated with alkalosis
                                                                                                                                              • Slide 90
                                                                                                                                              • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                              • Slide 92
                                                                                                                                              • Calcium
                                                                                                                                              • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                              • علائم هیپوکلسمی
                                                                                                                                              • Slide 96
                                                                                                                                              • Slide 97
                                                                                                                                              • Slide 98
                                                                                                                                              • Slide 99
                                                                                                                                              • سایرعلائم
                                                                                                                                              • درمان
                                                                                                                                              • هيپركلسمي Cagt55meql
                                                                                                                                              • علائم
                                                                                                                                              • علائم قلبی
                                                                                                                                              • Slide 105
                                                                                                                                              • Magnesium Abnormalities
                                                                                                                                              • منیزیوم
                                                                                                                                              • Hypermagnesemia
                                                                                                                                              • Clinical manifestation hypermanesemia
                                                                                                                                              • Slide 110
                                                                                                                                              • Slide 111
                                                                                                                                              • Hypomagnesemia
                                                                                                                                              • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                              • Slide 114
                                                                                                                                              • Message for Today
                                                                                                                                              • Slide 116

                                                                                                                                                Hyponatremia Nalt135mEqL

                                                                                                                                                Causes

                                                                                                                                                1 Sodium depletion

                                                                                                                                                2 Sodium dilution

                                                                                                                                                bull Incidence = 45

                                                                                                                                                bull After surgery=1

                                                                                                                                                bull Mortality = 2 times normal

                                                                                                                                                Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                                                                volume deficit

                                                                                                                                                Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                                                Sign and symptoms

                                                                                                                                                bull CNS symptom when Nalt123 meql

                                                                                                                                                bull Cardiac symptom when Nalt100 meql

                                                                                                                                                For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                                                Body System Hyponatremia

                                                                                                                                                central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                                                reflexes seizures coma increased intracranial pressure

                                                                                                                                                Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                                                Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                                                Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                                                intracranial pressure

                                                                                                                                                Tissue Lacrimation salivation

                                                                                                                                                Renal Oliguria

                                                                                                                                                Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                                                Treatment

                                                                                                                                                1=Depend on ECF

                                                                                                                                                2=CNS sign

                                                                                                                                                Treatment

                                                                                                                                                1 Asymptomatic increase the sodium level by no more than

                                                                                                                                                05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                                                2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                                                more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                                                meqL or neurologic symptoms are improved

                                                                                                                                                Rapid correction of hyponatremia

                                                                                                                                                Pontine myelinolysis

                                                                                                                                                Seizures weaknessparesis akinetic

                                                                                                                                                movements unresponsiveness

                                                                                                                                                Permanent brain damage

                                                                                                                                                Death

                                                                                                                                                Dose

                                                                                                                                                Na deficit meq =(140- Na meql) TBW

                                                                                                                                                باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                                                شود اصالح آهسته سپس

                                                                                                                                                Potassium abnormalities

                                                                                                                                                bull The average dietary intake of potassium 50-100meqd

                                                                                                                                                bull The average renal excretion of potassium 10-700 meqd

                                                                                                                                                - 2 of the total body potassium in ECF (45meqL)

                                                                                                                                                - Factors that influence serum potassium

                                                                                                                                                1 Surgical stress

                                                                                                                                                2 Injury

                                                                                                                                                3 Acidosis

                                                                                                                                                4 Tissue catabolism

                                                                                                                                                Hyperkalemia

                                                                                                                                                The normal range of serum potassium 35-5 meqL

                                                                                                                                                Etiology of Hyperkalemia

                                                                                                                                                Increased intake Potassium supplementation

                                                                                                                                                Blood transfusions

                                                                                                                                                Endogenous loaddestruction

                                                                                                                                                hemolysis rhabdomyolysis

                                                                                                                                                cruch injury gastrointestinal hemorrhage

                                                                                                                                                Increased release Acidosis

                                                                                                                                                Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                                Renal insufficiencyfailure

                                                                                                                                                Clinical manifestation of hyperkalemia

                                                                                                                                                System hyperkalemia

                                                                                                                                                Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                                Neuromuscular weakness paralysis respiratory failure

                                                                                                                                                Cardiovascular Arrhythmia arrest

                                                                                                                                                ECG changes Peaked T waves (early change)

                                                                                                                                                Flattened P wave

                                                                                                                                                Prolonged PR interval (first-degree block)

                                                                                                                                                Widened QRS complex

                                                                                                                                                Sine wave formation

                                                                                                                                                Ventricular fibrillation

                                                                                                                                                Treatment

                                                                                                                                                Treatment of symptomatic hyperkalemia

                                                                                                                                                Potassium removal Kayexalate

                                                                                                                                                Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                                Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                                Dialysis

                                                                                                                                                Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                                Bicarbonate 1 vial intravenous

                                                                                                                                                Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                                HypokalemiaEtiology

                                                                                                                                                inadequate intake

                                                                                                                                                Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                                total parenteral nutrition

                                                                                                                                                Excessive potassium excretion

                                                                                                                                                Hyperaldosteronism

                                                                                                                                                Medications

                                                                                                                                                Gastrointestinal losses

                                                                                                                                                Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                                Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                                nasogastric output)

                                                                                                                                                Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                                Potassium changes associated with alkalosis

                                                                                                                                                Potassium decrease by 03 meqL for every 01

                                                                                                                                                increase in PH above normal

                                                                                                                                                Magnesium Depletion

                                                                                                                                                (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                Renal potassium wastage

                                                                                                                                                Hypokalemia

                                                                                                                                                Magnesium Depletion

                                                                                                                                                (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                Renal potassium wastage

                                                                                                                                                Hypokalemia

                                                                                                                                                Clinical Manifestation of Abnormalities in potassium

                                                                                                                                                System hypokalemia

                                                                                                                                                Gastrointestinal Ileus constipation

                                                                                                                                                Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                                paralysis

                                                                                                                                                Cardiovascular Arrest

                                                                                                                                                ECG changes U-waves

                                                                                                                                                T-wave flattening

                                                                                                                                                ST-segment changes

                                                                                                                                                Arrhythmias

                                                                                                                                                Treatment

                                                                                                                                                Potassium

                                                                                                                                                Serum potassium level lt40 mEqL

                                                                                                                                                Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                                times 1 doses

                                                                                                                                                Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                                Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                                Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                                asymptomatic replace as per above protocol

                                                                                                                                                Electrolyte Replacement Therapy Protocol

                                                                                                                                                bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                                bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                                Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                صاف 2 عضالت انقباض

                                                                                                                                                هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                انعقاد 4

                                                                                                                                                یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                ( شود می پیوند شده

                                                                                                                                                هیپوکلسمی عالئم

                                                                                                                                                رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                سایرعالئم

                                                                                                                                                قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                درمان

                                                                                                                                                ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                Cagt55meql هيپركلسمي

                                                                                                                                                هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                عالئم

                                                                                                                                                bullGI

                                                                                                                                                bullCardiovascular bullRenal (polyuria)

                                                                                                                                                bullCNS

                                                                                                                                                قلبی عالئم

                                                                                                                                                bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                QRS شدن )Q-Tوكوتاه

                                                                                                                                                درمان

                                                                                                                                                ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                الزیکس2

                                                                                                                                                تونین 3 کلسی

                                                                                                                                                کورتون4

                                                                                                                                                دیالیز5

                                                                                                                                                Magnesium Abnormalities

                                                                                                                                                Normal dietary intake 20meq (240mg)

                                                                                                                                                Excretion in both the feces and urine

                                                                                                                                                Normal serum level 19-25 mgdL

                                                                                                                                                منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                Hypermagnesemia

                                                                                                                                                Etiology

                                                                                                                                                1 Impaired renal function

                                                                                                                                                2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                Clinical manifestation hypermanesemia

                                                                                                                                                System hypermanesemia

                                                                                                                                                Gastrointestinal Nauseavomiting

                                                                                                                                                Neuromuscular weakness lethargy Decreased

                                                                                                                                                reflexes

                                                                                                                                                Cardiovascular Hypotension arrest

                                                                                                                                                ECG changes Increased PR interval

                                                                                                                                                Widened QRS complex

                                                                                                                                                Elevated T waves

                                                                                                                                                Treatment

                                                                                                                                                1 Withhold exogenous sources of magnesium

                                                                                                                                                2 Correct volume deficit

                                                                                                                                                3 Correct acidosis if present

                                                                                                                                                4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                عالئم

                                                                                                                                                bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                meqL

                                                                                                                                                Hypomagnesemia

                                                                                                                                                Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                homeostasis

                                                                                                                                                Etiology

                                                                                                                                                1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                inadequate supplementation of magnesium)

                                                                                                                                                2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                3 GI losses (diarrhea)

                                                                                                                                                4 Malabsorption

                                                                                                                                                5 Acute pancreatitis

                                                                                                                                                6 Diabetic ketoacidosis

                                                                                                                                                7 Primary aldosteronism

                                                                                                                                                Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                2 Delirium and seizures in severe deficiency

                                                                                                                                                3 ECG changes Prolonged QT and PR interval

                                                                                                                                                ST-segment depression

                                                                                                                                                Flattening or inversion of P waves

                                                                                                                                                Torsades de pointes

                                                                                                                                                Arrhythmia

                                                                                                                                                Treatment

                                                                                                                                                1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                Message for Today

                                                                                                                                                ICF

                                                                                                                                                Interstitial

                                                                                                                                                Pla

                                                                                                                                                sma

                                                                                                                                                5 Dex

                                                                                                                                                bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                • Slide 2
                                                                                                                                                • Slide 3
                                                                                                                                                • Slide 4
                                                                                                                                                • Total Body Water
                                                                                                                                                • Body Fluid Compartments
                                                                                                                                                • Total body water (TBW)
                                                                                                                                                • Body compartment fluid
                                                                                                                                                • Example men with 70kg
                                                                                                                                                • Fluid compartments
                                                                                                                                                • Slide 11
                                                                                                                                                • Slide 12
                                                                                                                                                • Slide 13
                                                                                                                                                • Slide 14
                                                                                                                                                • Slide 15
                                                                                                                                                • Colloid osmotic pressure
                                                                                                                                                • Slide 17
                                                                                                                                                • Slide 18
                                                                                                                                                • Slide 19
                                                                                                                                                • Cell Membrane
                                                                                                                                                • Slide 21
                                                                                                                                                • Slide 22
                                                                                                                                                • Slide 23
                                                                                                                                                • Slide 24
                                                                                                                                                • Slide 25
                                                                                                                                                • Composition of Fluid Compartments
                                                                                                                                                • Composition of Body Fluids
                                                                                                                                                • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                • Reasons for fluid therapy
                                                                                                                                                • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                • محلولهای وریدی
                                                                                                                                                • Fluids
                                                                                                                                                • Slide 33
                                                                                                                                                • Slide 34
                                                                                                                                                • Slide 35
                                                                                                                                                • Crystalloids
                                                                                                                                                • Colloid Solutions
                                                                                                                                                • رینگر لاکتات
                                                                                                                                                • 09Nacl
                                                                                                                                                • Postoperative (maintenance)
                                                                                                                                                • Slide 41
                                                                                                                                                • Preexisting fluid deficits
                                                                                                                                                • Maintenance requirements
                                                                                                                                                • Surgical fluid losses
                                                                                                                                                • Third space loss
                                                                                                                                                • Crystalloid solution
                                                                                                                                                • Colloids
                                                                                                                                                • Complications
                                                                                                                                                • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                • Colloid versus crystalloid solutions
                                                                                                                                                • Transfusion consideration
                                                                                                                                                • اختلال در حجم مایعات بدن
                                                                                                                                                • Fluid volume deficit (FVD)
                                                                                                                                                • DEHYDRATION
                                                                                                                                                • علل کاهش حجم خارج سلولی
                                                                                                                                                • Signs of Hypovolemia
                                                                                                                                                • Clinical Diagnosis of Hypovolemia
                                                                                                                                                • Signs of Hypervolemia
                                                                                                                                                • Management of Hypervolemia
                                                                                                                                                • Fluid Management
                                                                                                                                                • Electrolyte physiology
                                                                                                                                                • Sodium physiology
                                                                                                                                                • Osmotic Pressure
                                                                                                                                                • Concentration
                                                                                                                                                • Hypernatremia
                                                                                                                                                • - Hypernatremia
                                                                                                                                                • Slide 67
                                                                                                                                                • Slide 68
                                                                                                                                                • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                • Treatment
                                                                                                                                                • Water deficit (L)= times TBW
                                                                                                                                                • The rate of fluid administration
                                                                                                                                                • Hyponatremia Nalt135mEqL
                                                                                                                                                • Slide 74
                                                                                                                                                • Sodium depletion
                                                                                                                                                • Sodium dilution
                                                                                                                                                • Sign and symptoms
                                                                                                                                                • Slide 78
                                                                                                                                                • Treatment
                                                                                                                                                • Slide 80
                                                                                                                                                • Slide 81
                                                                                                                                                • Dose
                                                                                                                                                • Potassium abnormalities
                                                                                                                                                • Hyperkalemia
                                                                                                                                                • Clinical manifestation of hyperkalemia
                                                                                                                                                • Slide 86
                                                                                                                                                • Slide 87
                                                                                                                                                • Hypokalemia
                                                                                                                                                • Potassium changes associated with alkalosis
                                                                                                                                                • Slide 90
                                                                                                                                                • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                • Slide 92
                                                                                                                                                • Calcium
                                                                                                                                                • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                • علائم هیپوکلسمی
                                                                                                                                                • Slide 96
                                                                                                                                                • Slide 97
                                                                                                                                                • Slide 98
                                                                                                                                                • Slide 99
                                                                                                                                                • سایرعلائم
                                                                                                                                                • درمان
                                                                                                                                                • هيپركلسمي Cagt55meql
                                                                                                                                                • علائم
                                                                                                                                                • علائم قلبی
                                                                                                                                                • Slide 105
                                                                                                                                                • Magnesium Abnormalities
                                                                                                                                                • منیزیوم
                                                                                                                                                • Hypermagnesemia
                                                                                                                                                • Clinical manifestation hypermanesemia
                                                                                                                                                • Slide 110
                                                                                                                                                • Slide 111
                                                                                                                                                • Hypomagnesemia
                                                                                                                                                • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                • Slide 114
                                                                                                                                                • Message for Today
                                                                                                                                                • Slide 116

                                                                                                                                                  bull Incidence = 45

                                                                                                                                                  bull After surgery=1

                                                                                                                                                  bull Mortality = 2 times normal

                                                                                                                                                  Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                                                                  volume deficit

                                                                                                                                                  Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                                                  Sign and symptoms

                                                                                                                                                  bull CNS symptom when Nalt123 meql

                                                                                                                                                  bull Cardiac symptom when Nalt100 meql

                                                                                                                                                  For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                                                  Body System Hyponatremia

                                                                                                                                                  central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                                                  reflexes seizures coma increased intracranial pressure

                                                                                                                                                  Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                                                  Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                                                  Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                                                  intracranial pressure

                                                                                                                                                  Tissue Lacrimation salivation

                                                                                                                                                  Renal Oliguria

                                                                                                                                                  Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                                                  Treatment

                                                                                                                                                  1=Depend on ECF

                                                                                                                                                  2=CNS sign

                                                                                                                                                  Treatment

                                                                                                                                                  1 Asymptomatic increase the sodium level by no more than

                                                                                                                                                  05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                                                  2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                                                  more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                                                  meqL or neurologic symptoms are improved

                                                                                                                                                  Rapid correction of hyponatremia

                                                                                                                                                  Pontine myelinolysis

                                                                                                                                                  Seizures weaknessparesis akinetic

                                                                                                                                                  movements unresponsiveness

                                                                                                                                                  Permanent brain damage

                                                                                                                                                  Death

                                                                                                                                                  Dose

                                                                                                                                                  Na deficit meq =(140- Na meql) TBW

                                                                                                                                                  باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                                                  شود اصالح آهسته سپس

                                                                                                                                                  Potassium abnormalities

                                                                                                                                                  bull The average dietary intake of potassium 50-100meqd

                                                                                                                                                  bull The average renal excretion of potassium 10-700 meqd

                                                                                                                                                  - 2 of the total body potassium in ECF (45meqL)

                                                                                                                                                  - Factors that influence serum potassium

                                                                                                                                                  1 Surgical stress

                                                                                                                                                  2 Injury

                                                                                                                                                  3 Acidosis

                                                                                                                                                  4 Tissue catabolism

                                                                                                                                                  Hyperkalemia

                                                                                                                                                  The normal range of serum potassium 35-5 meqL

                                                                                                                                                  Etiology of Hyperkalemia

                                                                                                                                                  Increased intake Potassium supplementation

                                                                                                                                                  Blood transfusions

                                                                                                                                                  Endogenous loaddestruction

                                                                                                                                                  hemolysis rhabdomyolysis

                                                                                                                                                  cruch injury gastrointestinal hemorrhage

                                                                                                                                                  Increased release Acidosis

                                                                                                                                                  Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                                  Renal insufficiencyfailure

                                                                                                                                                  Clinical manifestation of hyperkalemia

                                                                                                                                                  System hyperkalemia

                                                                                                                                                  Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                                  Neuromuscular weakness paralysis respiratory failure

                                                                                                                                                  Cardiovascular Arrhythmia arrest

                                                                                                                                                  ECG changes Peaked T waves (early change)

                                                                                                                                                  Flattened P wave

                                                                                                                                                  Prolonged PR interval (first-degree block)

                                                                                                                                                  Widened QRS complex

                                                                                                                                                  Sine wave formation

                                                                                                                                                  Ventricular fibrillation

                                                                                                                                                  Treatment

                                                                                                                                                  Treatment of symptomatic hyperkalemia

                                                                                                                                                  Potassium removal Kayexalate

                                                                                                                                                  Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                                  Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                                  Dialysis

                                                                                                                                                  Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                                  Bicarbonate 1 vial intravenous

                                                                                                                                                  Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                                  HypokalemiaEtiology

                                                                                                                                                  inadequate intake

                                                                                                                                                  Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                                  total parenteral nutrition

                                                                                                                                                  Excessive potassium excretion

                                                                                                                                                  Hyperaldosteronism

                                                                                                                                                  Medications

                                                                                                                                                  Gastrointestinal losses

                                                                                                                                                  Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                                  Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                                  nasogastric output)

                                                                                                                                                  Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                                  Potassium changes associated with alkalosis

                                                                                                                                                  Potassium decrease by 03 meqL for every 01

                                                                                                                                                  increase in PH above normal

                                                                                                                                                  Magnesium Depletion

                                                                                                                                                  (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                  Renal potassium wastage

                                                                                                                                                  Hypokalemia

                                                                                                                                                  Magnesium Depletion

                                                                                                                                                  (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                  Renal potassium wastage

                                                                                                                                                  Hypokalemia

                                                                                                                                                  Clinical Manifestation of Abnormalities in potassium

                                                                                                                                                  System hypokalemia

                                                                                                                                                  Gastrointestinal Ileus constipation

                                                                                                                                                  Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                                  paralysis

                                                                                                                                                  Cardiovascular Arrest

                                                                                                                                                  ECG changes U-waves

                                                                                                                                                  T-wave flattening

                                                                                                                                                  ST-segment changes

                                                                                                                                                  Arrhythmias

                                                                                                                                                  Treatment

                                                                                                                                                  Potassium

                                                                                                                                                  Serum potassium level lt40 mEqL

                                                                                                                                                  Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                                  times 1 doses

                                                                                                                                                  Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                                  Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                                  Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                                  asymptomatic replace as per above protocol

                                                                                                                                                  Electrolyte Replacement Therapy Protocol

                                                                                                                                                  bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                                  bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                                  Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                  ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                  عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                  صاف 2 عضالت انقباض

                                                                                                                                                  هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                  انعقاد 4

                                                                                                                                                  یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                  عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                  ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                  میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                  ( شود می پیوند شده

                                                                                                                                                  هیپوکلسمی عالئم

                                                                                                                                                  رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                  سایرعالئم

                                                                                                                                                  قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                  درمان

                                                                                                                                                  ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                  Cagt55meql هيپركلسمي

                                                                                                                                                  هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                  عالئم

                                                                                                                                                  bullGI

                                                                                                                                                  bullCardiovascular bullRenal (polyuria)

                                                                                                                                                  bullCNS

                                                                                                                                                  قلبی عالئم

                                                                                                                                                  bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                  QRS شدن )Q-Tوكوتاه

                                                                                                                                                  درمان

                                                                                                                                                  ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                  الزیکس2

                                                                                                                                                  تونین 3 کلسی

                                                                                                                                                  کورتون4

                                                                                                                                                  دیالیز5

                                                                                                                                                  Magnesium Abnormalities

                                                                                                                                                  Normal dietary intake 20meq (240mg)

                                                                                                                                                  Excretion in both the feces and urine

                                                                                                                                                  Normal serum level 19-25 mgdL

                                                                                                                                                  منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                  تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                  bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                  Hypermagnesemia

                                                                                                                                                  Etiology

                                                                                                                                                  1 Impaired renal function

                                                                                                                                                  2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                  Clinical manifestation hypermanesemia

                                                                                                                                                  System hypermanesemia

                                                                                                                                                  Gastrointestinal Nauseavomiting

                                                                                                                                                  Neuromuscular weakness lethargy Decreased

                                                                                                                                                  reflexes

                                                                                                                                                  Cardiovascular Hypotension arrest

                                                                                                                                                  ECG changes Increased PR interval

                                                                                                                                                  Widened QRS complex

                                                                                                                                                  Elevated T waves

                                                                                                                                                  Treatment

                                                                                                                                                  1 Withhold exogenous sources of magnesium

                                                                                                                                                  2 Correct volume deficit

                                                                                                                                                  3 Correct acidosis if present

                                                                                                                                                  4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                  5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                  عالئم

                                                                                                                                                  bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                  meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                  meqL

                                                                                                                                                  Hypomagnesemia

                                                                                                                                                  Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                  homeostasis

                                                                                                                                                  Etiology

                                                                                                                                                  1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                  inadequate supplementation of magnesium)

                                                                                                                                                  2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                  3 GI losses (diarrhea)

                                                                                                                                                  4 Malabsorption

                                                                                                                                                  5 Acute pancreatitis

                                                                                                                                                  6 Diabetic ketoacidosis

                                                                                                                                                  7 Primary aldosteronism

                                                                                                                                                  Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                  1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                  2 Delirium and seizures in severe deficiency

                                                                                                                                                  3 ECG changes Prolonged QT and PR interval

                                                                                                                                                  ST-segment depression

                                                                                                                                                  Flattening or inversion of P waves

                                                                                                                                                  Torsades de pointes

                                                                                                                                                  Arrhythmia

                                                                                                                                                  Treatment

                                                                                                                                                  1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                  2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                  Message for Today

                                                                                                                                                  ICF

                                                                                                                                                  Interstitial

                                                                                                                                                  Pla

                                                                                                                                                  sma

                                                                                                                                                  5 Dex

                                                                                                                                                  bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                  • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                  • Slide 2
                                                                                                                                                  • Slide 3
                                                                                                                                                  • Slide 4
                                                                                                                                                  • Total Body Water
                                                                                                                                                  • Body Fluid Compartments
                                                                                                                                                  • Total body water (TBW)
                                                                                                                                                  • Body compartment fluid
                                                                                                                                                  • Example men with 70kg
                                                                                                                                                  • Fluid compartments
                                                                                                                                                  • Slide 11
                                                                                                                                                  • Slide 12
                                                                                                                                                  • Slide 13
                                                                                                                                                  • Slide 14
                                                                                                                                                  • Slide 15
                                                                                                                                                  • Colloid osmotic pressure
                                                                                                                                                  • Slide 17
                                                                                                                                                  • Slide 18
                                                                                                                                                  • Slide 19
                                                                                                                                                  • Cell Membrane
                                                                                                                                                  • Slide 21
                                                                                                                                                  • Slide 22
                                                                                                                                                  • Slide 23
                                                                                                                                                  • Slide 24
                                                                                                                                                  • Slide 25
                                                                                                                                                  • Composition of Fluid Compartments
                                                                                                                                                  • Composition of Body Fluids
                                                                                                                                                  • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                  • Reasons for fluid therapy
                                                                                                                                                  • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                  • محلولهای وریدی
                                                                                                                                                  • Fluids
                                                                                                                                                  • Slide 33
                                                                                                                                                  • Slide 34
                                                                                                                                                  • Slide 35
                                                                                                                                                  • Crystalloids
                                                                                                                                                  • Colloid Solutions
                                                                                                                                                  • رینگر لاکتات
                                                                                                                                                  • 09Nacl
                                                                                                                                                  • Postoperative (maintenance)
                                                                                                                                                  • Slide 41
                                                                                                                                                  • Preexisting fluid deficits
                                                                                                                                                  • Maintenance requirements
                                                                                                                                                  • Surgical fluid losses
                                                                                                                                                  • Third space loss
                                                                                                                                                  • Crystalloid solution
                                                                                                                                                  • Colloids
                                                                                                                                                  • Complications
                                                                                                                                                  • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                  • Colloid versus crystalloid solutions
                                                                                                                                                  • Transfusion consideration
                                                                                                                                                  • اختلال در حجم مایعات بدن
                                                                                                                                                  • Fluid volume deficit (FVD)
                                                                                                                                                  • DEHYDRATION
                                                                                                                                                  • علل کاهش حجم خارج سلولی
                                                                                                                                                  • Signs of Hypovolemia
                                                                                                                                                  • Clinical Diagnosis of Hypovolemia
                                                                                                                                                  • Signs of Hypervolemia
                                                                                                                                                  • Management of Hypervolemia
                                                                                                                                                  • Fluid Management
                                                                                                                                                  • Electrolyte physiology
                                                                                                                                                  • Sodium physiology
                                                                                                                                                  • Osmotic Pressure
                                                                                                                                                  • Concentration
                                                                                                                                                  • Hypernatremia
                                                                                                                                                  • - Hypernatremia
                                                                                                                                                  • Slide 67
                                                                                                                                                  • Slide 68
                                                                                                                                                  • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                  • Treatment
                                                                                                                                                  • Water deficit (L)= times TBW
                                                                                                                                                  • The rate of fluid administration
                                                                                                                                                  • Hyponatremia Nalt135mEqL
                                                                                                                                                  • Slide 74
                                                                                                                                                  • Sodium depletion
                                                                                                                                                  • Sodium dilution
                                                                                                                                                  • Sign and symptoms
                                                                                                                                                  • Slide 78
                                                                                                                                                  • Treatment
                                                                                                                                                  • Slide 80
                                                                                                                                                  • Slide 81
                                                                                                                                                  • Dose
                                                                                                                                                  • Potassium abnormalities
                                                                                                                                                  • Hyperkalemia
                                                                                                                                                  • Clinical manifestation of hyperkalemia
                                                                                                                                                  • Slide 86
                                                                                                                                                  • Slide 87
                                                                                                                                                  • Hypokalemia
                                                                                                                                                  • Potassium changes associated with alkalosis
                                                                                                                                                  • Slide 90
                                                                                                                                                  • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                  • Slide 92
                                                                                                                                                  • Calcium
                                                                                                                                                  • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                  • علائم هیپوکلسمی
                                                                                                                                                  • Slide 96
                                                                                                                                                  • Slide 97
                                                                                                                                                  • Slide 98
                                                                                                                                                  • Slide 99
                                                                                                                                                  • سایرعلائم
                                                                                                                                                  • درمان
                                                                                                                                                  • هيپركلسمي Cagt55meql
                                                                                                                                                  • علائم
                                                                                                                                                  • علائم قلبی
                                                                                                                                                  • Slide 105
                                                                                                                                                  • Magnesium Abnormalities
                                                                                                                                                  • منیزیوم
                                                                                                                                                  • Hypermagnesemia
                                                                                                                                                  • Clinical manifestation hypermanesemia
                                                                                                                                                  • Slide 110
                                                                                                                                                  • Slide 111
                                                                                                                                                  • Hypomagnesemia
                                                                                                                                                  • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                  • Slide 114
                                                                                                                                                  • Message for Today
                                                                                                                                                  • Slide 116

                                                                                                                                                    Sodium depletion1 Decrease intake 1048699Low Na diet 1048699Enteral feeds2 Increase loss Gastrointestinal Losses 1048699Vomiting 1048699Prolonged NGT suctioning 1048699Diarrhea Renal Losses 1048699Diuretics 1048699Primary renal disease3 Depletional hyponatreamia is often accompanied by extracellulr

                                                                                                                                                    volume deficit

                                                                                                                                                    Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                                                    Sign and symptoms

                                                                                                                                                    bull CNS symptom when Nalt123 meql

                                                                                                                                                    bull Cardiac symptom when Nalt100 meql

                                                                                                                                                    For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                                                    Body System Hyponatremia

                                                                                                                                                    central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                                                    reflexes seizures coma increased intracranial pressure

                                                                                                                                                    Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                                                    Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                                                    Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                                                    intracranial pressure

                                                                                                                                                    Tissue Lacrimation salivation

                                                                                                                                                    Renal Oliguria

                                                                                                                                                    Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                                                    Treatment

                                                                                                                                                    1=Depend on ECF

                                                                                                                                                    2=CNS sign

                                                                                                                                                    Treatment

                                                                                                                                                    1 Asymptomatic increase the sodium level by no more than

                                                                                                                                                    05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                                                    2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                                                    more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                                                    meqL or neurologic symptoms are improved

                                                                                                                                                    Rapid correction of hyponatremia

                                                                                                                                                    Pontine myelinolysis

                                                                                                                                                    Seizures weaknessparesis akinetic

                                                                                                                                                    movements unresponsiveness

                                                                                                                                                    Permanent brain damage

                                                                                                                                                    Death

                                                                                                                                                    Dose

                                                                                                                                                    Na deficit meq =(140- Na meql) TBW

                                                                                                                                                    باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                                                    شود اصالح آهسته سپس

                                                                                                                                                    Potassium abnormalities

                                                                                                                                                    bull The average dietary intake of potassium 50-100meqd

                                                                                                                                                    bull The average renal excretion of potassium 10-700 meqd

                                                                                                                                                    - 2 of the total body potassium in ECF (45meqL)

                                                                                                                                                    - Factors that influence serum potassium

                                                                                                                                                    1 Surgical stress

                                                                                                                                                    2 Injury

                                                                                                                                                    3 Acidosis

                                                                                                                                                    4 Tissue catabolism

                                                                                                                                                    Hyperkalemia

                                                                                                                                                    The normal range of serum potassium 35-5 meqL

                                                                                                                                                    Etiology of Hyperkalemia

                                                                                                                                                    Increased intake Potassium supplementation

                                                                                                                                                    Blood transfusions

                                                                                                                                                    Endogenous loaddestruction

                                                                                                                                                    hemolysis rhabdomyolysis

                                                                                                                                                    cruch injury gastrointestinal hemorrhage

                                                                                                                                                    Increased release Acidosis

                                                                                                                                                    Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                                    Renal insufficiencyfailure

                                                                                                                                                    Clinical manifestation of hyperkalemia

                                                                                                                                                    System hyperkalemia

                                                                                                                                                    Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                                    Neuromuscular weakness paralysis respiratory failure

                                                                                                                                                    Cardiovascular Arrhythmia arrest

                                                                                                                                                    ECG changes Peaked T waves (early change)

                                                                                                                                                    Flattened P wave

                                                                                                                                                    Prolonged PR interval (first-degree block)

                                                                                                                                                    Widened QRS complex

                                                                                                                                                    Sine wave formation

                                                                                                                                                    Ventricular fibrillation

                                                                                                                                                    Treatment

                                                                                                                                                    Treatment of symptomatic hyperkalemia

                                                                                                                                                    Potassium removal Kayexalate

                                                                                                                                                    Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                                    Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                                    Dialysis

                                                                                                                                                    Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                                    Bicarbonate 1 vial intravenous

                                                                                                                                                    Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                                    HypokalemiaEtiology

                                                                                                                                                    inadequate intake

                                                                                                                                                    Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                                    total parenteral nutrition

                                                                                                                                                    Excessive potassium excretion

                                                                                                                                                    Hyperaldosteronism

                                                                                                                                                    Medications

                                                                                                                                                    Gastrointestinal losses

                                                                                                                                                    Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                                    Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                                    nasogastric output)

                                                                                                                                                    Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                                    Potassium changes associated with alkalosis

                                                                                                                                                    Potassium decrease by 03 meqL for every 01

                                                                                                                                                    increase in PH above normal

                                                                                                                                                    Magnesium Depletion

                                                                                                                                                    (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                    Renal potassium wastage

                                                                                                                                                    Hypokalemia

                                                                                                                                                    Magnesium Depletion

                                                                                                                                                    (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                    Renal potassium wastage

                                                                                                                                                    Hypokalemia

                                                                                                                                                    Clinical Manifestation of Abnormalities in potassium

                                                                                                                                                    System hypokalemia

                                                                                                                                                    Gastrointestinal Ileus constipation

                                                                                                                                                    Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                                    paralysis

                                                                                                                                                    Cardiovascular Arrest

                                                                                                                                                    ECG changes U-waves

                                                                                                                                                    T-wave flattening

                                                                                                                                                    ST-segment changes

                                                                                                                                                    Arrhythmias

                                                                                                                                                    Treatment

                                                                                                                                                    Potassium

                                                                                                                                                    Serum potassium level lt40 mEqL

                                                                                                                                                    Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                                    times 1 doses

                                                                                                                                                    Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                                    Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                                    Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                                    asymptomatic replace as per above protocol

                                                                                                                                                    Electrolyte Replacement Therapy Protocol

                                                                                                                                                    bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                                    bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                                    Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                    ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                    عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                    صاف 2 عضالت انقباض

                                                                                                                                                    هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                    انعقاد 4

                                                                                                                                                    یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                    عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                    ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                    میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                    ( شود می پیوند شده

                                                                                                                                                    هیپوکلسمی عالئم

                                                                                                                                                    رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                    سایرعالئم

                                                                                                                                                    قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                    درمان

                                                                                                                                                    ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                    Cagt55meql هيپركلسمي

                                                                                                                                                    هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                    عالئم

                                                                                                                                                    bullGI

                                                                                                                                                    bullCardiovascular bullRenal (polyuria)

                                                                                                                                                    bullCNS

                                                                                                                                                    قلبی عالئم

                                                                                                                                                    bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                    QRS شدن )Q-Tوكوتاه

                                                                                                                                                    درمان

                                                                                                                                                    ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                    الزیکس2

                                                                                                                                                    تونین 3 کلسی

                                                                                                                                                    کورتون4

                                                                                                                                                    دیالیز5

                                                                                                                                                    Magnesium Abnormalities

                                                                                                                                                    Normal dietary intake 20meq (240mg)

                                                                                                                                                    Excretion in both the feces and urine

                                                                                                                                                    Normal serum level 19-25 mgdL

                                                                                                                                                    منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                    تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                    bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                    Hypermagnesemia

                                                                                                                                                    Etiology

                                                                                                                                                    1 Impaired renal function

                                                                                                                                                    2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                    Clinical manifestation hypermanesemia

                                                                                                                                                    System hypermanesemia

                                                                                                                                                    Gastrointestinal Nauseavomiting

                                                                                                                                                    Neuromuscular weakness lethargy Decreased

                                                                                                                                                    reflexes

                                                                                                                                                    Cardiovascular Hypotension arrest

                                                                                                                                                    ECG changes Increased PR interval

                                                                                                                                                    Widened QRS complex

                                                                                                                                                    Elevated T waves

                                                                                                                                                    Treatment

                                                                                                                                                    1 Withhold exogenous sources of magnesium

                                                                                                                                                    2 Correct volume deficit

                                                                                                                                                    3 Correct acidosis if present

                                                                                                                                                    4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                    5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                    عالئم

                                                                                                                                                    bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                    meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                    meqL

                                                                                                                                                    Hypomagnesemia

                                                                                                                                                    Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                    homeostasis

                                                                                                                                                    Etiology

                                                                                                                                                    1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                    inadequate supplementation of magnesium)

                                                                                                                                                    2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                    3 GI losses (diarrhea)

                                                                                                                                                    4 Malabsorption

                                                                                                                                                    5 Acute pancreatitis

                                                                                                                                                    6 Diabetic ketoacidosis

                                                                                                                                                    7 Primary aldosteronism

                                                                                                                                                    Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                    1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                    2 Delirium and seizures in severe deficiency

                                                                                                                                                    3 ECG changes Prolonged QT and PR interval

                                                                                                                                                    ST-segment depression

                                                                                                                                                    Flattening or inversion of P waves

                                                                                                                                                    Torsades de pointes

                                                                                                                                                    Arrhythmia

                                                                                                                                                    Treatment

                                                                                                                                                    1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                    2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                    Message for Today

                                                                                                                                                    ICF

                                                                                                                                                    Interstitial

                                                                                                                                                    Pla

                                                                                                                                                    sma

                                                                                                                                                    5 Dex

                                                                                                                                                    bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                    • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                    • Slide 2
                                                                                                                                                    • Slide 3
                                                                                                                                                    • Slide 4
                                                                                                                                                    • Total Body Water
                                                                                                                                                    • Body Fluid Compartments
                                                                                                                                                    • Total body water (TBW)
                                                                                                                                                    • Body compartment fluid
                                                                                                                                                    • Example men with 70kg
                                                                                                                                                    • Fluid compartments
                                                                                                                                                    • Slide 11
                                                                                                                                                    • Slide 12
                                                                                                                                                    • Slide 13
                                                                                                                                                    • Slide 14
                                                                                                                                                    • Slide 15
                                                                                                                                                    • Colloid osmotic pressure
                                                                                                                                                    • Slide 17
                                                                                                                                                    • Slide 18
                                                                                                                                                    • Slide 19
                                                                                                                                                    • Cell Membrane
                                                                                                                                                    • Slide 21
                                                                                                                                                    • Slide 22
                                                                                                                                                    • Slide 23
                                                                                                                                                    • Slide 24
                                                                                                                                                    • Slide 25
                                                                                                                                                    • Composition of Fluid Compartments
                                                                                                                                                    • Composition of Body Fluids
                                                                                                                                                    • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                    • Reasons for fluid therapy
                                                                                                                                                    • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                    • محلولهای وریدی
                                                                                                                                                    • Fluids
                                                                                                                                                    • Slide 33
                                                                                                                                                    • Slide 34
                                                                                                                                                    • Slide 35
                                                                                                                                                    • Crystalloids
                                                                                                                                                    • Colloid Solutions
                                                                                                                                                    • رینگر لاکتات
                                                                                                                                                    • 09Nacl
                                                                                                                                                    • Postoperative (maintenance)
                                                                                                                                                    • Slide 41
                                                                                                                                                    • Preexisting fluid deficits
                                                                                                                                                    • Maintenance requirements
                                                                                                                                                    • Surgical fluid losses
                                                                                                                                                    • Third space loss
                                                                                                                                                    • Crystalloid solution
                                                                                                                                                    • Colloids
                                                                                                                                                    • Complications
                                                                                                                                                    • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                    • Colloid versus crystalloid solutions
                                                                                                                                                    • Transfusion consideration
                                                                                                                                                    • اختلال در حجم مایعات بدن
                                                                                                                                                    • Fluid volume deficit (FVD)
                                                                                                                                                    • DEHYDRATION
                                                                                                                                                    • علل کاهش حجم خارج سلولی
                                                                                                                                                    • Signs of Hypovolemia
                                                                                                                                                    • Clinical Diagnosis of Hypovolemia
                                                                                                                                                    • Signs of Hypervolemia
                                                                                                                                                    • Management of Hypervolemia
                                                                                                                                                    • Fluid Management
                                                                                                                                                    • Electrolyte physiology
                                                                                                                                                    • Sodium physiology
                                                                                                                                                    • Osmotic Pressure
                                                                                                                                                    • Concentration
                                                                                                                                                    • Hypernatremia
                                                                                                                                                    • - Hypernatremia
                                                                                                                                                    • Slide 67
                                                                                                                                                    • Slide 68
                                                                                                                                                    • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                    • Treatment
                                                                                                                                                    • Water deficit (L)= times TBW
                                                                                                                                                    • The rate of fluid administration
                                                                                                                                                    • Hyponatremia Nalt135mEqL
                                                                                                                                                    • Slide 74
                                                                                                                                                    • Sodium depletion
                                                                                                                                                    • Sodium dilution
                                                                                                                                                    • Sign and symptoms
                                                                                                                                                    • Slide 78
                                                                                                                                                    • Treatment
                                                                                                                                                    • Slide 80
                                                                                                                                                    • Slide 81
                                                                                                                                                    • Dose
                                                                                                                                                    • Potassium abnormalities
                                                                                                                                                    • Hyperkalemia
                                                                                                                                                    • Clinical manifestation of hyperkalemia
                                                                                                                                                    • Slide 86
                                                                                                                                                    • Slide 87
                                                                                                                                                    • Hypokalemia
                                                                                                                                                    • Potassium changes associated with alkalosis
                                                                                                                                                    • Slide 90
                                                                                                                                                    • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                    • Slide 92
                                                                                                                                                    • Calcium
                                                                                                                                                    • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                    • علائم هیپوکلسمی
                                                                                                                                                    • Slide 96
                                                                                                                                                    • Slide 97
                                                                                                                                                    • Slide 98
                                                                                                                                                    • Slide 99
                                                                                                                                                    • سایرعلائم
                                                                                                                                                    • درمان
                                                                                                                                                    • هيپركلسمي Cagt55meql
                                                                                                                                                    • علائم
                                                                                                                                                    • علائم قلبی
                                                                                                                                                    • Slide 105
                                                                                                                                                    • Magnesium Abnormalities
                                                                                                                                                    • منیزیوم
                                                                                                                                                    • Hypermagnesemia
                                                                                                                                                    • Clinical manifestation hypermanesemia
                                                                                                                                                    • Slide 110
                                                                                                                                                    • Slide 111
                                                                                                                                                    • Hypomagnesemia
                                                                                                                                                    • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                    • Slide 114
                                                                                                                                                    • Message for Today
                                                                                                                                                    • Slide 116

                                                                                                                                                      Sodium dilution1 Due to excess extracellular water 1048699Intentional excessive oral intake 1048699Iatrogenic Intravenous2 Drugs 1048699Antipsychotics 1048699Tricyclic antidepressants 1048699Angiotensin-converting enzyme inhibitors3 Hyperosmolar 1048699Mannitol 1048699Hyperglycemia4Pseudohyponatremia 1048699Plasma lipids 1048699Plasma proteins

                                                                                                                                                      Sign and symptoms

                                                                                                                                                      bull CNS symptom when Nalt123 meql

                                                                                                                                                      bull Cardiac symptom when Nalt100 meql

                                                                                                                                                      For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                                                      Body System Hyponatremia

                                                                                                                                                      central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                                                      reflexes seizures coma increased intracranial pressure

                                                                                                                                                      Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                                                      Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                                                      Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                                                      intracranial pressure

                                                                                                                                                      Tissue Lacrimation salivation

                                                                                                                                                      Renal Oliguria

                                                                                                                                                      Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                                                      Treatment

                                                                                                                                                      1=Depend on ECF

                                                                                                                                                      2=CNS sign

                                                                                                                                                      Treatment

                                                                                                                                                      1 Asymptomatic increase the sodium level by no more than

                                                                                                                                                      05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                                                      2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                                                      more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                                                      meqL or neurologic symptoms are improved

                                                                                                                                                      Rapid correction of hyponatremia

                                                                                                                                                      Pontine myelinolysis

                                                                                                                                                      Seizures weaknessparesis akinetic

                                                                                                                                                      movements unresponsiveness

                                                                                                                                                      Permanent brain damage

                                                                                                                                                      Death

                                                                                                                                                      Dose

                                                                                                                                                      Na deficit meq =(140- Na meql) TBW

                                                                                                                                                      باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                                                      شود اصالح آهسته سپس

                                                                                                                                                      Potassium abnormalities

                                                                                                                                                      bull The average dietary intake of potassium 50-100meqd

                                                                                                                                                      bull The average renal excretion of potassium 10-700 meqd

                                                                                                                                                      - 2 of the total body potassium in ECF (45meqL)

                                                                                                                                                      - Factors that influence serum potassium

                                                                                                                                                      1 Surgical stress

                                                                                                                                                      2 Injury

                                                                                                                                                      3 Acidosis

                                                                                                                                                      4 Tissue catabolism

                                                                                                                                                      Hyperkalemia

                                                                                                                                                      The normal range of serum potassium 35-5 meqL

                                                                                                                                                      Etiology of Hyperkalemia

                                                                                                                                                      Increased intake Potassium supplementation

                                                                                                                                                      Blood transfusions

                                                                                                                                                      Endogenous loaddestruction

                                                                                                                                                      hemolysis rhabdomyolysis

                                                                                                                                                      cruch injury gastrointestinal hemorrhage

                                                                                                                                                      Increased release Acidosis

                                                                                                                                                      Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                                      Renal insufficiencyfailure

                                                                                                                                                      Clinical manifestation of hyperkalemia

                                                                                                                                                      System hyperkalemia

                                                                                                                                                      Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                                      Neuromuscular weakness paralysis respiratory failure

                                                                                                                                                      Cardiovascular Arrhythmia arrest

                                                                                                                                                      ECG changes Peaked T waves (early change)

                                                                                                                                                      Flattened P wave

                                                                                                                                                      Prolonged PR interval (first-degree block)

                                                                                                                                                      Widened QRS complex

                                                                                                                                                      Sine wave formation

                                                                                                                                                      Ventricular fibrillation

                                                                                                                                                      Treatment

                                                                                                                                                      Treatment of symptomatic hyperkalemia

                                                                                                                                                      Potassium removal Kayexalate

                                                                                                                                                      Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                                      Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                                      Dialysis

                                                                                                                                                      Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                                      Bicarbonate 1 vial intravenous

                                                                                                                                                      Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                                      HypokalemiaEtiology

                                                                                                                                                      inadequate intake

                                                                                                                                                      Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                                      total parenteral nutrition

                                                                                                                                                      Excessive potassium excretion

                                                                                                                                                      Hyperaldosteronism

                                                                                                                                                      Medications

                                                                                                                                                      Gastrointestinal losses

                                                                                                                                                      Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                                      Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                                      nasogastric output)

                                                                                                                                                      Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                                      Potassium changes associated with alkalosis

                                                                                                                                                      Potassium decrease by 03 meqL for every 01

                                                                                                                                                      increase in PH above normal

                                                                                                                                                      Magnesium Depletion

                                                                                                                                                      (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                      Renal potassium wastage

                                                                                                                                                      Hypokalemia

                                                                                                                                                      Magnesium Depletion

                                                                                                                                                      (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                      Renal potassium wastage

                                                                                                                                                      Hypokalemia

                                                                                                                                                      Clinical Manifestation of Abnormalities in potassium

                                                                                                                                                      System hypokalemia

                                                                                                                                                      Gastrointestinal Ileus constipation

                                                                                                                                                      Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                                      paralysis

                                                                                                                                                      Cardiovascular Arrest

                                                                                                                                                      ECG changes U-waves

                                                                                                                                                      T-wave flattening

                                                                                                                                                      ST-segment changes

                                                                                                                                                      Arrhythmias

                                                                                                                                                      Treatment

                                                                                                                                                      Potassium

                                                                                                                                                      Serum potassium level lt40 mEqL

                                                                                                                                                      Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                                      times 1 doses

                                                                                                                                                      Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                                      Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                                      Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                                      asymptomatic replace as per above protocol

                                                                                                                                                      Electrolyte Replacement Therapy Protocol

                                                                                                                                                      bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                                      bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                                      Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                      ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                      عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                      صاف 2 عضالت انقباض

                                                                                                                                                      هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                      انعقاد 4

                                                                                                                                                      یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                      عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                      ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                      میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                      ( شود می پیوند شده

                                                                                                                                                      هیپوکلسمی عالئم

                                                                                                                                                      رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                      سایرعالئم

                                                                                                                                                      قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                      درمان

                                                                                                                                                      ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                      Cagt55meql هيپركلسمي

                                                                                                                                                      هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                      عالئم

                                                                                                                                                      bullGI

                                                                                                                                                      bullCardiovascular bullRenal (polyuria)

                                                                                                                                                      bullCNS

                                                                                                                                                      قلبی عالئم

                                                                                                                                                      bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                      QRS شدن )Q-Tوكوتاه

                                                                                                                                                      درمان

                                                                                                                                                      ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                      الزیکس2

                                                                                                                                                      تونین 3 کلسی

                                                                                                                                                      کورتون4

                                                                                                                                                      دیالیز5

                                                                                                                                                      Magnesium Abnormalities

                                                                                                                                                      Normal dietary intake 20meq (240mg)

                                                                                                                                                      Excretion in both the feces and urine

                                                                                                                                                      Normal serum level 19-25 mgdL

                                                                                                                                                      منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                      تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                      bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                      Hypermagnesemia

                                                                                                                                                      Etiology

                                                                                                                                                      1 Impaired renal function

                                                                                                                                                      2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                      Clinical manifestation hypermanesemia

                                                                                                                                                      System hypermanesemia

                                                                                                                                                      Gastrointestinal Nauseavomiting

                                                                                                                                                      Neuromuscular weakness lethargy Decreased

                                                                                                                                                      reflexes

                                                                                                                                                      Cardiovascular Hypotension arrest

                                                                                                                                                      ECG changes Increased PR interval

                                                                                                                                                      Widened QRS complex

                                                                                                                                                      Elevated T waves

                                                                                                                                                      Treatment

                                                                                                                                                      1 Withhold exogenous sources of magnesium

                                                                                                                                                      2 Correct volume deficit

                                                                                                                                                      3 Correct acidosis if present

                                                                                                                                                      4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                      5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                      عالئم

                                                                                                                                                      bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                      meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                      meqL

                                                                                                                                                      Hypomagnesemia

                                                                                                                                                      Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                      homeostasis

                                                                                                                                                      Etiology

                                                                                                                                                      1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                      inadequate supplementation of magnesium)

                                                                                                                                                      2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                      3 GI losses (diarrhea)

                                                                                                                                                      4 Malabsorption

                                                                                                                                                      5 Acute pancreatitis

                                                                                                                                                      6 Diabetic ketoacidosis

                                                                                                                                                      7 Primary aldosteronism

                                                                                                                                                      Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                      1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                      2 Delirium and seizures in severe deficiency

                                                                                                                                                      3 ECG changes Prolonged QT and PR interval

                                                                                                                                                      ST-segment depression

                                                                                                                                                      Flattening or inversion of P waves

                                                                                                                                                      Torsades de pointes

                                                                                                                                                      Arrhythmia

                                                                                                                                                      Treatment

                                                                                                                                                      1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                      2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                      Message for Today

                                                                                                                                                      ICF

                                                                                                                                                      Interstitial

                                                                                                                                                      Pla

                                                                                                                                                      sma

                                                                                                                                                      5 Dex

                                                                                                                                                      bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                      • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                      • Slide 2
                                                                                                                                                      • Slide 3
                                                                                                                                                      • Slide 4
                                                                                                                                                      • Total Body Water
                                                                                                                                                      • Body Fluid Compartments
                                                                                                                                                      • Total body water (TBW)
                                                                                                                                                      • Body compartment fluid
                                                                                                                                                      • Example men with 70kg
                                                                                                                                                      • Fluid compartments
                                                                                                                                                      • Slide 11
                                                                                                                                                      • Slide 12
                                                                                                                                                      • Slide 13
                                                                                                                                                      • Slide 14
                                                                                                                                                      • Slide 15
                                                                                                                                                      • Colloid osmotic pressure
                                                                                                                                                      • Slide 17
                                                                                                                                                      • Slide 18
                                                                                                                                                      • Slide 19
                                                                                                                                                      • Cell Membrane
                                                                                                                                                      • Slide 21
                                                                                                                                                      • Slide 22
                                                                                                                                                      • Slide 23
                                                                                                                                                      • Slide 24
                                                                                                                                                      • Slide 25
                                                                                                                                                      • Composition of Fluid Compartments
                                                                                                                                                      • Composition of Body Fluids
                                                                                                                                                      • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                      • Reasons for fluid therapy
                                                                                                                                                      • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                      • محلولهای وریدی
                                                                                                                                                      • Fluids
                                                                                                                                                      • Slide 33
                                                                                                                                                      • Slide 34
                                                                                                                                                      • Slide 35
                                                                                                                                                      • Crystalloids
                                                                                                                                                      • Colloid Solutions
                                                                                                                                                      • رینگر لاکتات
                                                                                                                                                      • 09Nacl
                                                                                                                                                      • Postoperative (maintenance)
                                                                                                                                                      • Slide 41
                                                                                                                                                      • Preexisting fluid deficits
                                                                                                                                                      • Maintenance requirements
                                                                                                                                                      • Surgical fluid losses
                                                                                                                                                      • Third space loss
                                                                                                                                                      • Crystalloid solution
                                                                                                                                                      • Colloids
                                                                                                                                                      • Complications
                                                                                                                                                      • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                      • Colloid versus crystalloid solutions
                                                                                                                                                      • Transfusion consideration
                                                                                                                                                      • اختلال در حجم مایعات بدن
                                                                                                                                                      • Fluid volume deficit (FVD)
                                                                                                                                                      • DEHYDRATION
                                                                                                                                                      • علل کاهش حجم خارج سلولی
                                                                                                                                                      • Signs of Hypovolemia
                                                                                                                                                      • Clinical Diagnosis of Hypovolemia
                                                                                                                                                      • Signs of Hypervolemia
                                                                                                                                                      • Management of Hypervolemia
                                                                                                                                                      • Fluid Management
                                                                                                                                                      • Electrolyte physiology
                                                                                                                                                      • Sodium physiology
                                                                                                                                                      • Osmotic Pressure
                                                                                                                                                      • Concentration
                                                                                                                                                      • Hypernatremia
                                                                                                                                                      • - Hypernatremia
                                                                                                                                                      • Slide 67
                                                                                                                                                      • Slide 68
                                                                                                                                                      • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                      • Treatment
                                                                                                                                                      • Water deficit (L)= times TBW
                                                                                                                                                      • The rate of fluid administration
                                                                                                                                                      • Hyponatremia Nalt135mEqL
                                                                                                                                                      • Slide 74
                                                                                                                                                      • Sodium depletion
                                                                                                                                                      • Sodium dilution
                                                                                                                                                      • Sign and symptoms
                                                                                                                                                      • Slide 78
                                                                                                                                                      • Treatment
                                                                                                                                                      • Slide 80
                                                                                                                                                      • Slide 81
                                                                                                                                                      • Dose
                                                                                                                                                      • Potassium abnormalities
                                                                                                                                                      • Hyperkalemia
                                                                                                                                                      • Clinical manifestation of hyperkalemia
                                                                                                                                                      • Slide 86
                                                                                                                                                      • Slide 87
                                                                                                                                                      • Hypokalemia
                                                                                                                                                      • Potassium changes associated with alkalosis
                                                                                                                                                      • Slide 90
                                                                                                                                                      • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                      • Slide 92
                                                                                                                                                      • Calcium
                                                                                                                                                      • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                      • علائم هیپوکلسمی
                                                                                                                                                      • Slide 96
                                                                                                                                                      • Slide 97
                                                                                                                                                      • Slide 98
                                                                                                                                                      • Slide 99
                                                                                                                                                      • سایرعلائم
                                                                                                                                                      • درمان
                                                                                                                                                      • هيپركلسمي Cagt55meql
                                                                                                                                                      • علائم
                                                                                                                                                      • علائم قلبی
                                                                                                                                                      • Slide 105
                                                                                                                                                      • Magnesium Abnormalities
                                                                                                                                                      • منیزیوم
                                                                                                                                                      • Hypermagnesemia
                                                                                                                                                      • Clinical manifestation hypermanesemia
                                                                                                                                                      • Slide 110
                                                                                                                                                      • Slide 111
                                                                                                                                                      • Hypomagnesemia
                                                                                                                                                      • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                      • Slide 114
                                                                                                                                                      • Message for Today
                                                                                                                                                      • Slide 116

                                                                                                                                                        Sign and symptoms

                                                                                                                                                        bull CNS symptom when Nalt123 meql

                                                                                                                                                        bull Cardiac symptom when Nalt100 meql

                                                                                                                                                        For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                                                        Body System Hyponatremia

                                                                                                                                                        central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                                                        reflexes seizures coma increased intracranial pressure

                                                                                                                                                        Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                                                        Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                                                        Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                                                        intracranial pressure

                                                                                                                                                        Tissue Lacrimation salivation

                                                                                                                                                        Renal Oliguria

                                                                                                                                                        Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                                                        Treatment

                                                                                                                                                        1=Depend on ECF

                                                                                                                                                        2=CNS sign

                                                                                                                                                        Treatment

                                                                                                                                                        1 Asymptomatic increase the sodium level by no more than

                                                                                                                                                        05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                                                        2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                                                        more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                                                        meqL or neurologic symptoms are improved

                                                                                                                                                        Rapid correction of hyponatremia

                                                                                                                                                        Pontine myelinolysis

                                                                                                                                                        Seizures weaknessparesis akinetic

                                                                                                                                                        movements unresponsiveness

                                                                                                                                                        Permanent brain damage

                                                                                                                                                        Death

                                                                                                                                                        Dose

                                                                                                                                                        Na deficit meq =(140- Na meql) TBW

                                                                                                                                                        باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                                                        شود اصالح آهسته سپس

                                                                                                                                                        Potassium abnormalities

                                                                                                                                                        bull The average dietary intake of potassium 50-100meqd

                                                                                                                                                        bull The average renal excretion of potassium 10-700 meqd

                                                                                                                                                        - 2 of the total body potassium in ECF (45meqL)

                                                                                                                                                        - Factors that influence serum potassium

                                                                                                                                                        1 Surgical stress

                                                                                                                                                        2 Injury

                                                                                                                                                        3 Acidosis

                                                                                                                                                        4 Tissue catabolism

                                                                                                                                                        Hyperkalemia

                                                                                                                                                        The normal range of serum potassium 35-5 meqL

                                                                                                                                                        Etiology of Hyperkalemia

                                                                                                                                                        Increased intake Potassium supplementation

                                                                                                                                                        Blood transfusions

                                                                                                                                                        Endogenous loaddestruction

                                                                                                                                                        hemolysis rhabdomyolysis

                                                                                                                                                        cruch injury gastrointestinal hemorrhage

                                                                                                                                                        Increased release Acidosis

                                                                                                                                                        Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                                        Renal insufficiencyfailure

                                                                                                                                                        Clinical manifestation of hyperkalemia

                                                                                                                                                        System hyperkalemia

                                                                                                                                                        Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                                        Neuromuscular weakness paralysis respiratory failure

                                                                                                                                                        Cardiovascular Arrhythmia arrest

                                                                                                                                                        ECG changes Peaked T waves (early change)

                                                                                                                                                        Flattened P wave

                                                                                                                                                        Prolonged PR interval (first-degree block)

                                                                                                                                                        Widened QRS complex

                                                                                                                                                        Sine wave formation

                                                                                                                                                        Ventricular fibrillation

                                                                                                                                                        Treatment

                                                                                                                                                        Treatment of symptomatic hyperkalemia

                                                                                                                                                        Potassium removal Kayexalate

                                                                                                                                                        Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                                        Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                                        Dialysis

                                                                                                                                                        Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                                        Bicarbonate 1 vial intravenous

                                                                                                                                                        Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                                        HypokalemiaEtiology

                                                                                                                                                        inadequate intake

                                                                                                                                                        Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                                        total parenteral nutrition

                                                                                                                                                        Excessive potassium excretion

                                                                                                                                                        Hyperaldosteronism

                                                                                                                                                        Medications

                                                                                                                                                        Gastrointestinal losses

                                                                                                                                                        Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                                        Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                                        nasogastric output)

                                                                                                                                                        Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                                        Potassium changes associated with alkalosis

                                                                                                                                                        Potassium decrease by 03 meqL for every 01

                                                                                                                                                        increase in PH above normal

                                                                                                                                                        Magnesium Depletion

                                                                                                                                                        (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                        Renal potassium wastage

                                                                                                                                                        Hypokalemia

                                                                                                                                                        Magnesium Depletion

                                                                                                                                                        (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                        Renal potassium wastage

                                                                                                                                                        Hypokalemia

                                                                                                                                                        Clinical Manifestation of Abnormalities in potassium

                                                                                                                                                        System hypokalemia

                                                                                                                                                        Gastrointestinal Ileus constipation

                                                                                                                                                        Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                                        paralysis

                                                                                                                                                        Cardiovascular Arrest

                                                                                                                                                        ECG changes U-waves

                                                                                                                                                        T-wave flattening

                                                                                                                                                        ST-segment changes

                                                                                                                                                        Arrhythmias

                                                                                                                                                        Treatment

                                                                                                                                                        Potassium

                                                                                                                                                        Serum potassium level lt40 mEqL

                                                                                                                                                        Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                                        times 1 doses

                                                                                                                                                        Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                                        Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                                        Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                                        asymptomatic replace as per above protocol

                                                                                                                                                        Electrolyte Replacement Therapy Protocol

                                                                                                                                                        bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                                        bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                                        Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                        ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                        عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                        صاف 2 عضالت انقباض

                                                                                                                                                        هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                        انعقاد 4

                                                                                                                                                        یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                        عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                        ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                        میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                        ( شود می پیوند شده

                                                                                                                                                        هیپوکلسمی عالئم

                                                                                                                                                        رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                        سایرعالئم

                                                                                                                                                        قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                        درمان

                                                                                                                                                        ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                        Cagt55meql هيپركلسمي

                                                                                                                                                        هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                        عالئم

                                                                                                                                                        bullGI

                                                                                                                                                        bullCardiovascular bullRenal (polyuria)

                                                                                                                                                        bullCNS

                                                                                                                                                        قلبی عالئم

                                                                                                                                                        bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                        QRS شدن )Q-Tوكوتاه

                                                                                                                                                        درمان

                                                                                                                                                        ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                        الزیکس2

                                                                                                                                                        تونین 3 کلسی

                                                                                                                                                        کورتون4

                                                                                                                                                        دیالیز5

                                                                                                                                                        Magnesium Abnormalities

                                                                                                                                                        Normal dietary intake 20meq (240mg)

                                                                                                                                                        Excretion in both the feces and urine

                                                                                                                                                        Normal serum level 19-25 mgdL

                                                                                                                                                        منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                        تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                        bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                        Hypermagnesemia

                                                                                                                                                        Etiology

                                                                                                                                                        1 Impaired renal function

                                                                                                                                                        2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                        Clinical manifestation hypermanesemia

                                                                                                                                                        System hypermanesemia

                                                                                                                                                        Gastrointestinal Nauseavomiting

                                                                                                                                                        Neuromuscular weakness lethargy Decreased

                                                                                                                                                        reflexes

                                                                                                                                                        Cardiovascular Hypotension arrest

                                                                                                                                                        ECG changes Increased PR interval

                                                                                                                                                        Widened QRS complex

                                                                                                                                                        Elevated T waves

                                                                                                                                                        Treatment

                                                                                                                                                        1 Withhold exogenous sources of magnesium

                                                                                                                                                        2 Correct volume deficit

                                                                                                                                                        3 Correct acidosis if present

                                                                                                                                                        4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                        5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                        عالئم

                                                                                                                                                        bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                        meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                        meqL

                                                                                                                                                        Hypomagnesemia

                                                                                                                                                        Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                        homeostasis

                                                                                                                                                        Etiology

                                                                                                                                                        1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                        inadequate supplementation of magnesium)

                                                                                                                                                        2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                        3 GI losses (diarrhea)

                                                                                                                                                        4 Malabsorption

                                                                                                                                                        5 Acute pancreatitis

                                                                                                                                                        6 Diabetic ketoacidosis

                                                                                                                                                        7 Primary aldosteronism

                                                                                                                                                        Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                        1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                        2 Delirium and seizures in severe deficiency

                                                                                                                                                        3 ECG changes Prolonged QT and PR interval

                                                                                                                                                        ST-segment depression

                                                                                                                                                        Flattening or inversion of P waves

                                                                                                                                                        Torsades de pointes

                                                                                                                                                        Arrhythmia

                                                                                                                                                        Treatment

                                                                                                                                                        1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                        2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                        Message for Today

                                                                                                                                                        ICF

                                                                                                                                                        Interstitial

                                                                                                                                                        Pla

                                                                                                                                                        sma

                                                                                                                                                        5 Dex

                                                                                                                                                        bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                        • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                        • Slide 2
                                                                                                                                                        • Slide 3
                                                                                                                                                        • Slide 4
                                                                                                                                                        • Total Body Water
                                                                                                                                                        • Body Fluid Compartments
                                                                                                                                                        • Total body water (TBW)
                                                                                                                                                        • Body compartment fluid
                                                                                                                                                        • Example men with 70kg
                                                                                                                                                        • Fluid compartments
                                                                                                                                                        • Slide 11
                                                                                                                                                        • Slide 12
                                                                                                                                                        • Slide 13
                                                                                                                                                        • Slide 14
                                                                                                                                                        • Slide 15
                                                                                                                                                        • Colloid osmotic pressure
                                                                                                                                                        • Slide 17
                                                                                                                                                        • Slide 18
                                                                                                                                                        • Slide 19
                                                                                                                                                        • Cell Membrane
                                                                                                                                                        • Slide 21
                                                                                                                                                        • Slide 22
                                                                                                                                                        • Slide 23
                                                                                                                                                        • Slide 24
                                                                                                                                                        • Slide 25
                                                                                                                                                        • Composition of Fluid Compartments
                                                                                                                                                        • Composition of Body Fluids
                                                                                                                                                        • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                        • Reasons for fluid therapy
                                                                                                                                                        • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                        • محلولهای وریدی
                                                                                                                                                        • Fluids
                                                                                                                                                        • Slide 33
                                                                                                                                                        • Slide 34
                                                                                                                                                        • Slide 35
                                                                                                                                                        • Crystalloids
                                                                                                                                                        • Colloid Solutions
                                                                                                                                                        • رینگر لاکتات
                                                                                                                                                        • 09Nacl
                                                                                                                                                        • Postoperative (maintenance)
                                                                                                                                                        • Slide 41
                                                                                                                                                        • Preexisting fluid deficits
                                                                                                                                                        • Maintenance requirements
                                                                                                                                                        • Surgical fluid losses
                                                                                                                                                        • Third space loss
                                                                                                                                                        • Crystalloid solution
                                                                                                                                                        • Colloids
                                                                                                                                                        • Complications
                                                                                                                                                        • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                        • Colloid versus crystalloid solutions
                                                                                                                                                        • Transfusion consideration
                                                                                                                                                        • اختلال در حجم مایعات بدن
                                                                                                                                                        • Fluid volume deficit (FVD)
                                                                                                                                                        • DEHYDRATION
                                                                                                                                                        • علل کاهش حجم خارج سلولی
                                                                                                                                                        • Signs of Hypovolemia
                                                                                                                                                        • Clinical Diagnosis of Hypovolemia
                                                                                                                                                        • Signs of Hypervolemia
                                                                                                                                                        • Management of Hypervolemia
                                                                                                                                                        • Fluid Management
                                                                                                                                                        • Electrolyte physiology
                                                                                                                                                        • Sodium physiology
                                                                                                                                                        • Osmotic Pressure
                                                                                                                                                        • Concentration
                                                                                                                                                        • Hypernatremia
                                                                                                                                                        • - Hypernatremia
                                                                                                                                                        • Slide 67
                                                                                                                                                        • Slide 68
                                                                                                                                                        • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                        • Treatment
                                                                                                                                                        • Water deficit (L)= times TBW
                                                                                                                                                        • The rate of fluid administration
                                                                                                                                                        • Hyponatremia Nalt135mEqL
                                                                                                                                                        • Slide 74
                                                                                                                                                        • Sodium depletion
                                                                                                                                                        • Sodium dilution
                                                                                                                                                        • Sign and symptoms
                                                                                                                                                        • Slide 78
                                                                                                                                                        • Treatment
                                                                                                                                                        • Slide 80
                                                                                                                                                        • Slide 81
                                                                                                                                                        • Dose
                                                                                                                                                        • Potassium abnormalities
                                                                                                                                                        • Hyperkalemia
                                                                                                                                                        • Clinical manifestation of hyperkalemia
                                                                                                                                                        • Slide 86
                                                                                                                                                        • Slide 87
                                                                                                                                                        • Hypokalemia
                                                                                                                                                        • Potassium changes associated with alkalosis
                                                                                                                                                        • Slide 90
                                                                                                                                                        • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                        • Slide 92
                                                                                                                                                        • Calcium
                                                                                                                                                        • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                        • علائم هیپوکلسمی
                                                                                                                                                        • Slide 96
                                                                                                                                                        • Slide 97
                                                                                                                                                        • Slide 98
                                                                                                                                                        • Slide 99
                                                                                                                                                        • سایرعلائم
                                                                                                                                                        • درمان
                                                                                                                                                        • هيپركلسمي Cagt55meql
                                                                                                                                                        • علائم
                                                                                                                                                        • علائم قلبی
                                                                                                                                                        • Slide 105
                                                                                                                                                        • Magnesium Abnormalities
                                                                                                                                                        • منیزیوم
                                                                                                                                                        • Hypermagnesemia
                                                                                                                                                        • Clinical manifestation hypermanesemia
                                                                                                                                                        • Slide 110
                                                                                                                                                        • Slide 111
                                                                                                                                                        • Hypomagnesemia
                                                                                                                                                        • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                        • Slide 114
                                                                                                                                                        • Message for Today
                                                                                                                                                        • Slide 116

                                                                                                                                                          For every 100 mgdL increment in plasma glucose above normal the plasma sodium should decrease by 16 mEqL

                                                                                                                                                          Body System Hyponatremia

                                                                                                                                                          central nervous system Headache confusion hyper-or hypoactive deep tendon

                                                                                                                                                          reflexes seizures coma increased intracranial pressure

                                                                                                                                                          Musculoskeletal Weakness fatigue muscle crampstwitching

                                                                                                                                                          Gastrointestinal Anorexia nausea vomiting watery diarrhea

                                                                                                                                                          Cardiovascular Hypertension and bradycardia if significant increases in

                                                                                                                                                          intracranial pressure

                                                                                                                                                          Tissue Lacrimation salivation

                                                                                                                                                          Renal Oliguria

                                                                                                                                                          Clinical Manifestations of Abnormalities in Serum Sodium

                                                                                                                                                          Treatment

                                                                                                                                                          1=Depend on ECF

                                                                                                                                                          2=CNS sign

                                                                                                                                                          Treatment

                                                                                                                                                          1 Asymptomatic increase the sodium level by no more than

                                                                                                                                                          05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                                                          2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                                                          more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                                                          meqL or neurologic symptoms are improved

                                                                                                                                                          Rapid correction of hyponatremia

                                                                                                                                                          Pontine myelinolysis

                                                                                                                                                          Seizures weaknessparesis akinetic

                                                                                                                                                          movements unresponsiveness

                                                                                                                                                          Permanent brain damage

                                                                                                                                                          Death

                                                                                                                                                          Dose

                                                                                                                                                          Na deficit meq =(140- Na meql) TBW

                                                                                                                                                          باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                                                          شود اصالح آهسته سپس

                                                                                                                                                          Potassium abnormalities

                                                                                                                                                          bull The average dietary intake of potassium 50-100meqd

                                                                                                                                                          bull The average renal excretion of potassium 10-700 meqd

                                                                                                                                                          - 2 of the total body potassium in ECF (45meqL)

                                                                                                                                                          - Factors that influence serum potassium

                                                                                                                                                          1 Surgical stress

                                                                                                                                                          2 Injury

                                                                                                                                                          3 Acidosis

                                                                                                                                                          4 Tissue catabolism

                                                                                                                                                          Hyperkalemia

                                                                                                                                                          The normal range of serum potassium 35-5 meqL

                                                                                                                                                          Etiology of Hyperkalemia

                                                                                                                                                          Increased intake Potassium supplementation

                                                                                                                                                          Blood transfusions

                                                                                                                                                          Endogenous loaddestruction

                                                                                                                                                          hemolysis rhabdomyolysis

                                                                                                                                                          cruch injury gastrointestinal hemorrhage

                                                                                                                                                          Increased release Acidosis

                                                                                                                                                          Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                                          Renal insufficiencyfailure

                                                                                                                                                          Clinical manifestation of hyperkalemia

                                                                                                                                                          System hyperkalemia

                                                                                                                                                          Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                                          Neuromuscular weakness paralysis respiratory failure

                                                                                                                                                          Cardiovascular Arrhythmia arrest

                                                                                                                                                          ECG changes Peaked T waves (early change)

                                                                                                                                                          Flattened P wave

                                                                                                                                                          Prolonged PR interval (first-degree block)

                                                                                                                                                          Widened QRS complex

                                                                                                                                                          Sine wave formation

                                                                                                                                                          Ventricular fibrillation

                                                                                                                                                          Treatment

                                                                                                                                                          Treatment of symptomatic hyperkalemia

                                                                                                                                                          Potassium removal Kayexalate

                                                                                                                                                          Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                                          Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                                          Dialysis

                                                                                                                                                          Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                                          Bicarbonate 1 vial intravenous

                                                                                                                                                          Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                                          HypokalemiaEtiology

                                                                                                                                                          inadequate intake

                                                                                                                                                          Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                                          total parenteral nutrition

                                                                                                                                                          Excessive potassium excretion

                                                                                                                                                          Hyperaldosteronism

                                                                                                                                                          Medications

                                                                                                                                                          Gastrointestinal losses

                                                                                                                                                          Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                                          Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                                          nasogastric output)

                                                                                                                                                          Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                                          Potassium changes associated with alkalosis

                                                                                                                                                          Potassium decrease by 03 meqL for every 01

                                                                                                                                                          increase in PH above normal

                                                                                                                                                          Magnesium Depletion

                                                                                                                                                          (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                          Renal potassium wastage

                                                                                                                                                          Hypokalemia

                                                                                                                                                          Magnesium Depletion

                                                                                                                                                          (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                          Renal potassium wastage

                                                                                                                                                          Hypokalemia

                                                                                                                                                          Clinical Manifestation of Abnormalities in potassium

                                                                                                                                                          System hypokalemia

                                                                                                                                                          Gastrointestinal Ileus constipation

                                                                                                                                                          Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                                          paralysis

                                                                                                                                                          Cardiovascular Arrest

                                                                                                                                                          ECG changes U-waves

                                                                                                                                                          T-wave flattening

                                                                                                                                                          ST-segment changes

                                                                                                                                                          Arrhythmias

                                                                                                                                                          Treatment

                                                                                                                                                          Potassium

                                                                                                                                                          Serum potassium level lt40 mEqL

                                                                                                                                                          Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                                          times 1 doses

                                                                                                                                                          Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                                          Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                                          Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                                          asymptomatic replace as per above protocol

                                                                                                                                                          Electrolyte Replacement Therapy Protocol

                                                                                                                                                          bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                                          bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                                          Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                          ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                          عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                          صاف 2 عضالت انقباض

                                                                                                                                                          هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                          انعقاد 4

                                                                                                                                                          یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                          عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                          ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                          میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                          ( شود می پیوند شده

                                                                                                                                                          هیپوکلسمی عالئم

                                                                                                                                                          رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                          سایرعالئم

                                                                                                                                                          قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                          درمان

                                                                                                                                                          ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                          Cagt55meql هيپركلسمي

                                                                                                                                                          هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                          عالئم

                                                                                                                                                          bullGI

                                                                                                                                                          bullCardiovascular bullRenal (polyuria)

                                                                                                                                                          bullCNS

                                                                                                                                                          قلبی عالئم

                                                                                                                                                          bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                          QRS شدن )Q-Tوكوتاه

                                                                                                                                                          درمان

                                                                                                                                                          ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                          الزیکس2

                                                                                                                                                          تونین 3 کلسی

                                                                                                                                                          کورتون4

                                                                                                                                                          دیالیز5

                                                                                                                                                          Magnesium Abnormalities

                                                                                                                                                          Normal dietary intake 20meq (240mg)

                                                                                                                                                          Excretion in both the feces and urine

                                                                                                                                                          Normal serum level 19-25 mgdL

                                                                                                                                                          منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                          تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                          bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                          Hypermagnesemia

                                                                                                                                                          Etiology

                                                                                                                                                          1 Impaired renal function

                                                                                                                                                          2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                          Clinical manifestation hypermanesemia

                                                                                                                                                          System hypermanesemia

                                                                                                                                                          Gastrointestinal Nauseavomiting

                                                                                                                                                          Neuromuscular weakness lethargy Decreased

                                                                                                                                                          reflexes

                                                                                                                                                          Cardiovascular Hypotension arrest

                                                                                                                                                          ECG changes Increased PR interval

                                                                                                                                                          Widened QRS complex

                                                                                                                                                          Elevated T waves

                                                                                                                                                          Treatment

                                                                                                                                                          1 Withhold exogenous sources of magnesium

                                                                                                                                                          2 Correct volume deficit

                                                                                                                                                          3 Correct acidosis if present

                                                                                                                                                          4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                          5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                          عالئم

                                                                                                                                                          bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                          meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                          meqL

                                                                                                                                                          Hypomagnesemia

                                                                                                                                                          Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                          homeostasis

                                                                                                                                                          Etiology

                                                                                                                                                          1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                          inadequate supplementation of magnesium)

                                                                                                                                                          2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                          3 GI losses (diarrhea)

                                                                                                                                                          4 Malabsorption

                                                                                                                                                          5 Acute pancreatitis

                                                                                                                                                          6 Diabetic ketoacidosis

                                                                                                                                                          7 Primary aldosteronism

                                                                                                                                                          Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                          1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                          2 Delirium and seizures in severe deficiency

                                                                                                                                                          3 ECG changes Prolonged QT and PR interval

                                                                                                                                                          ST-segment depression

                                                                                                                                                          Flattening or inversion of P waves

                                                                                                                                                          Torsades de pointes

                                                                                                                                                          Arrhythmia

                                                                                                                                                          Treatment

                                                                                                                                                          1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                          2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                          Message for Today

                                                                                                                                                          ICF

                                                                                                                                                          Interstitial

                                                                                                                                                          Pla

                                                                                                                                                          sma

                                                                                                                                                          5 Dex

                                                                                                                                                          bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                          • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                          • Slide 2
                                                                                                                                                          • Slide 3
                                                                                                                                                          • Slide 4
                                                                                                                                                          • Total Body Water
                                                                                                                                                          • Body Fluid Compartments
                                                                                                                                                          • Total body water (TBW)
                                                                                                                                                          • Body compartment fluid
                                                                                                                                                          • Example men with 70kg
                                                                                                                                                          • Fluid compartments
                                                                                                                                                          • Slide 11
                                                                                                                                                          • Slide 12
                                                                                                                                                          • Slide 13
                                                                                                                                                          • Slide 14
                                                                                                                                                          • Slide 15
                                                                                                                                                          • Colloid osmotic pressure
                                                                                                                                                          • Slide 17
                                                                                                                                                          • Slide 18
                                                                                                                                                          • Slide 19
                                                                                                                                                          • Cell Membrane
                                                                                                                                                          • Slide 21
                                                                                                                                                          • Slide 22
                                                                                                                                                          • Slide 23
                                                                                                                                                          • Slide 24
                                                                                                                                                          • Slide 25
                                                                                                                                                          • Composition of Fluid Compartments
                                                                                                                                                          • Composition of Body Fluids
                                                                                                                                                          • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                          • Reasons for fluid therapy
                                                                                                                                                          • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                          • محلولهای وریدی
                                                                                                                                                          • Fluids
                                                                                                                                                          • Slide 33
                                                                                                                                                          • Slide 34
                                                                                                                                                          • Slide 35
                                                                                                                                                          • Crystalloids
                                                                                                                                                          • Colloid Solutions
                                                                                                                                                          • رینگر لاکتات
                                                                                                                                                          • 09Nacl
                                                                                                                                                          • Postoperative (maintenance)
                                                                                                                                                          • Slide 41
                                                                                                                                                          • Preexisting fluid deficits
                                                                                                                                                          • Maintenance requirements
                                                                                                                                                          • Surgical fluid losses
                                                                                                                                                          • Third space loss
                                                                                                                                                          • Crystalloid solution
                                                                                                                                                          • Colloids
                                                                                                                                                          • Complications
                                                                                                                                                          • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                          • Colloid versus crystalloid solutions
                                                                                                                                                          • Transfusion consideration
                                                                                                                                                          • اختلال در حجم مایعات بدن
                                                                                                                                                          • Fluid volume deficit (FVD)
                                                                                                                                                          • DEHYDRATION
                                                                                                                                                          • علل کاهش حجم خارج سلولی
                                                                                                                                                          • Signs of Hypovolemia
                                                                                                                                                          • Clinical Diagnosis of Hypovolemia
                                                                                                                                                          • Signs of Hypervolemia
                                                                                                                                                          • Management of Hypervolemia
                                                                                                                                                          • Fluid Management
                                                                                                                                                          • Electrolyte physiology
                                                                                                                                                          • Sodium physiology
                                                                                                                                                          • Osmotic Pressure
                                                                                                                                                          • Concentration
                                                                                                                                                          • Hypernatremia
                                                                                                                                                          • - Hypernatremia
                                                                                                                                                          • Slide 67
                                                                                                                                                          • Slide 68
                                                                                                                                                          • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                          • Treatment
                                                                                                                                                          • Water deficit (L)= times TBW
                                                                                                                                                          • The rate of fluid administration
                                                                                                                                                          • Hyponatremia Nalt135mEqL
                                                                                                                                                          • Slide 74
                                                                                                                                                          • Sodium depletion
                                                                                                                                                          • Sodium dilution
                                                                                                                                                          • Sign and symptoms
                                                                                                                                                          • Slide 78
                                                                                                                                                          • Treatment
                                                                                                                                                          • Slide 80
                                                                                                                                                          • Slide 81
                                                                                                                                                          • Dose
                                                                                                                                                          • Potassium abnormalities
                                                                                                                                                          • Hyperkalemia
                                                                                                                                                          • Clinical manifestation of hyperkalemia
                                                                                                                                                          • Slide 86
                                                                                                                                                          • Slide 87
                                                                                                                                                          • Hypokalemia
                                                                                                                                                          • Potassium changes associated with alkalosis
                                                                                                                                                          • Slide 90
                                                                                                                                                          • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                          • Slide 92
                                                                                                                                                          • Calcium
                                                                                                                                                          • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                          • علائم هیپوکلسمی
                                                                                                                                                          • Slide 96
                                                                                                                                                          • Slide 97
                                                                                                                                                          • Slide 98
                                                                                                                                                          • Slide 99
                                                                                                                                                          • سایرعلائم
                                                                                                                                                          • درمان
                                                                                                                                                          • هيپركلسمي Cagt55meql
                                                                                                                                                          • علائم
                                                                                                                                                          • علائم قلبی
                                                                                                                                                          • Slide 105
                                                                                                                                                          • Magnesium Abnormalities
                                                                                                                                                          • منیزیوم
                                                                                                                                                          • Hypermagnesemia
                                                                                                                                                          • Clinical manifestation hypermanesemia
                                                                                                                                                          • Slide 110
                                                                                                                                                          • Slide 111
                                                                                                                                                          • Hypomagnesemia
                                                                                                                                                          • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                          • Slide 114
                                                                                                                                                          • Message for Today
                                                                                                                                                          • Slide 116

                                                                                                                                                            Treatment

                                                                                                                                                            1=Depend on ECF

                                                                                                                                                            2=CNS sign

                                                                                                                                                            Treatment

                                                                                                                                                            1 Asymptomatic increase the sodium level by no more than

                                                                                                                                                            05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                                                            2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                                                            more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                                                            meqL or neurologic symptoms are improved

                                                                                                                                                            Rapid correction of hyponatremia

                                                                                                                                                            Pontine myelinolysis

                                                                                                                                                            Seizures weaknessparesis akinetic

                                                                                                                                                            movements unresponsiveness

                                                                                                                                                            Permanent brain damage

                                                                                                                                                            Death

                                                                                                                                                            Dose

                                                                                                                                                            Na deficit meq =(140- Na meql) TBW

                                                                                                                                                            باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                                                            شود اصالح آهسته سپس

                                                                                                                                                            Potassium abnormalities

                                                                                                                                                            bull The average dietary intake of potassium 50-100meqd

                                                                                                                                                            bull The average renal excretion of potassium 10-700 meqd

                                                                                                                                                            - 2 of the total body potassium in ECF (45meqL)

                                                                                                                                                            - Factors that influence serum potassium

                                                                                                                                                            1 Surgical stress

                                                                                                                                                            2 Injury

                                                                                                                                                            3 Acidosis

                                                                                                                                                            4 Tissue catabolism

                                                                                                                                                            Hyperkalemia

                                                                                                                                                            The normal range of serum potassium 35-5 meqL

                                                                                                                                                            Etiology of Hyperkalemia

                                                                                                                                                            Increased intake Potassium supplementation

                                                                                                                                                            Blood transfusions

                                                                                                                                                            Endogenous loaddestruction

                                                                                                                                                            hemolysis rhabdomyolysis

                                                                                                                                                            cruch injury gastrointestinal hemorrhage

                                                                                                                                                            Increased release Acidosis

                                                                                                                                                            Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                                            Renal insufficiencyfailure

                                                                                                                                                            Clinical manifestation of hyperkalemia

                                                                                                                                                            System hyperkalemia

                                                                                                                                                            Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                                            Neuromuscular weakness paralysis respiratory failure

                                                                                                                                                            Cardiovascular Arrhythmia arrest

                                                                                                                                                            ECG changes Peaked T waves (early change)

                                                                                                                                                            Flattened P wave

                                                                                                                                                            Prolonged PR interval (first-degree block)

                                                                                                                                                            Widened QRS complex

                                                                                                                                                            Sine wave formation

                                                                                                                                                            Ventricular fibrillation

                                                                                                                                                            Treatment

                                                                                                                                                            Treatment of symptomatic hyperkalemia

                                                                                                                                                            Potassium removal Kayexalate

                                                                                                                                                            Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                                            Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                                            Dialysis

                                                                                                                                                            Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                                            Bicarbonate 1 vial intravenous

                                                                                                                                                            Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                                            HypokalemiaEtiology

                                                                                                                                                            inadequate intake

                                                                                                                                                            Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                                            total parenteral nutrition

                                                                                                                                                            Excessive potassium excretion

                                                                                                                                                            Hyperaldosteronism

                                                                                                                                                            Medications

                                                                                                                                                            Gastrointestinal losses

                                                                                                                                                            Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                                            Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                                            nasogastric output)

                                                                                                                                                            Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                                            Potassium changes associated with alkalosis

                                                                                                                                                            Potassium decrease by 03 meqL for every 01

                                                                                                                                                            increase in PH above normal

                                                                                                                                                            Magnesium Depletion

                                                                                                                                                            (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                            Renal potassium wastage

                                                                                                                                                            Hypokalemia

                                                                                                                                                            Magnesium Depletion

                                                                                                                                                            (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                            Renal potassium wastage

                                                                                                                                                            Hypokalemia

                                                                                                                                                            Clinical Manifestation of Abnormalities in potassium

                                                                                                                                                            System hypokalemia

                                                                                                                                                            Gastrointestinal Ileus constipation

                                                                                                                                                            Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                                            paralysis

                                                                                                                                                            Cardiovascular Arrest

                                                                                                                                                            ECG changes U-waves

                                                                                                                                                            T-wave flattening

                                                                                                                                                            ST-segment changes

                                                                                                                                                            Arrhythmias

                                                                                                                                                            Treatment

                                                                                                                                                            Potassium

                                                                                                                                                            Serum potassium level lt40 mEqL

                                                                                                                                                            Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                                            times 1 doses

                                                                                                                                                            Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                                            Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                                            Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                                            asymptomatic replace as per above protocol

                                                                                                                                                            Electrolyte Replacement Therapy Protocol

                                                                                                                                                            bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                                            bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                                            Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                            ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                            عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                            صاف 2 عضالت انقباض

                                                                                                                                                            هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                            انعقاد 4

                                                                                                                                                            یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                            عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                            ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                            میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                            ( شود می پیوند شده

                                                                                                                                                            هیپوکلسمی عالئم

                                                                                                                                                            رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                            سایرعالئم

                                                                                                                                                            قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                            درمان

                                                                                                                                                            ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                            Cagt55meql هيپركلسمي

                                                                                                                                                            هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                            عالئم

                                                                                                                                                            bullGI

                                                                                                                                                            bullCardiovascular bullRenal (polyuria)

                                                                                                                                                            bullCNS

                                                                                                                                                            قلبی عالئم

                                                                                                                                                            bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                            QRS شدن )Q-Tوكوتاه

                                                                                                                                                            درمان

                                                                                                                                                            ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                            الزیکس2

                                                                                                                                                            تونین 3 کلسی

                                                                                                                                                            کورتون4

                                                                                                                                                            دیالیز5

                                                                                                                                                            Magnesium Abnormalities

                                                                                                                                                            Normal dietary intake 20meq (240mg)

                                                                                                                                                            Excretion in both the feces and urine

                                                                                                                                                            Normal serum level 19-25 mgdL

                                                                                                                                                            منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                            تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                            bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                            Hypermagnesemia

                                                                                                                                                            Etiology

                                                                                                                                                            1 Impaired renal function

                                                                                                                                                            2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                            Clinical manifestation hypermanesemia

                                                                                                                                                            System hypermanesemia

                                                                                                                                                            Gastrointestinal Nauseavomiting

                                                                                                                                                            Neuromuscular weakness lethargy Decreased

                                                                                                                                                            reflexes

                                                                                                                                                            Cardiovascular Hypotension arrest

                                                                                                                                                            ECG changes Increased PR interval

                                                                                                                                                            Widened QRS complex

                                                                                                                                                            Elevated T waves

                                                                                                                                                            Treatment

                                                                                                                                                            1 Withhold exogenous sources of magnesium

                                                                                                                                                            2 Correct volume deficit

                                                                                                                                                            3 Correct acidosis if present

                                                                                                                                                            4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                            5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                            عالئم

                                                                                                                                                            bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                            meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                            meqL

                                                                                                                                                            Hypomagnesemia

                                                                                                                                                            Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                            homeostasis

                                                                                                                                                            Etiology

                                                                                                                                                            1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                            inadequate supplementation of magnesium)

                                                                                                                                                            2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                            3 GI losses (diarrhea)

                                                                                                                                                            4 Malabsorption

                                                                                                                                                            5 Acute pancreatitis

                                                                                                                                                            6 Diabetic ketoacidosis

                                                                                                                                                            7 Primary aldosteronism

                                                                                                                                                            Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                            1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                            2 Delirium and seizures in severe deficiency

                                                                                                                                                            3 ECG changes Prolonged QT and PR interval

                                                                                                                                                            ST-segment depression

                                                                                                                                                            Flattening or inversion of P waves

                                                                                                                                                            Torsades de pointes

                                                                                                                                                            Arrhythmia

                                                                                                                                                            Treatment

                                                                                                                                                            1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                            2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                            Message for Today

                                                                                                                                                            ICF

                                                                                                                                                            Interstitial

                                                                                                                                                            Pla

                                                                                                                                                            sma

                                                                                                                                                            5 Dex

                                                                                                                                                            bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                            • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                            • Slide 2
                                                                                                                                                            • Slide 3
                                                                                                                                                            • Slide 4
                                                                                                                                                            • Total Body Water
                                                                                                                                                            • Body Fluid Compartments
                                                                                                                                                            • Total body water (TBW)
                                                                                                                                                            • Body compartment fluid
                                                                                                                                                            • Example men with 70kg
                                                                                                                                                            • Fluid compartments
                                                                                                                                                            • Slide 11
                                                                                                                                                            • Slide 12
                                                                                                                                                            • Slide 13
                                                                                                                                                            • Slide 14
                                                                                                                                                            • Slide 15
                                                                                                                                                            • Colloid osmotic pressure
                                                                                                                                                            • Slide 17
                                                                                                                                                            • Slide 18
                                                                                                                                                            • Slide 19
                                                                                                                                                            • Cell Membrane
                                                                                                                                                            • Slide 21
                                                                                                                                                            • Slide 22
                                                                                                                                                            • Slide 23
                                                                                                                                                            • Slide 24
                                                                                                                                                            • Slide 25
                                                                                                                                                            • Composition of Fluid Compartments
                                                                                                                                                            • Composition of Body Fluids
                                                                                                                                                            • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                            • Reasons for fluid therapy
                                                                                                                                                            • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                            • محلولهای وریدی
                                                                                                                                                            • Fluids
                                                                                                                                                            • Slide 33
                                                                                                                                                            • Slide 34
                                                                                                                                                            • Slide 35
                                                                                                                                                            • Crystalloids
                                                                                                                                                            • Colloid Solutions
                                                                                                                                                            • رینگر لاکتات
                                                                                                                                                            • 09Nacl
                                                                                                                                                            • Postoperative (maintenance)
                                                                                                                                                            • Slide 41
                                                                                                                                                            • Preexisting fluid deficits
                                                                                                                                                            • Maintenance requirements
                                                                                                                                                            • Surgical fluid losses
                                                                                                                                                            • Third space loss
                                                                                                                                                            • Crystalloid solution
                                                                                                                                                            • Colloids
                                                                                                                                                            • Complications
                                                                                                                                                            • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                            • Colloid versus crystalloid solutions
                                                                                                                                                            • Transfusion consideration
                                                                                                                                                            • اختلال در حجم مایعات بدن
                                                                                                                                                            • Fluid volume deficit (FVD)
                                                                                                                                                            • DEHYDRATION
                                                                                                                                                            • علل کاهش حجم خارج سلولی
                                                                                                                                                            • Signs of Hypovolemia
                                                                                                                                                            • Clinical Diagnosis of Hypovolemia
                                                                                                                                                            • Signs of Hypervolemia
                                                                                                                                                            • Management of Hypervolemia
                                                                                                                                                            • Fluid Management
                                                                                                                                                            • Electrolyte physiology
                                                                                                                                                            • Sodium physiology
                                                                                                                                                            • Osmotic Pressure
                                                                                                                                                            • Concentration
                                                                                                                                                            • Hypernatremia
                                                                                                                                                            • - Hypernatremia
                                                                                                                                                            • Slide 67
                                                                                                                                                            • Slide 68
                                                                                                                                                            • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                            • Treatment
                                                                                                                                                            • Water deficit (L)= times TBW
                                                                                                                                                            • The rate of fluid administration
                                                                                                                                                            • Hyponatremia Nalt135mEqL
                                                                                                                                                            • Slide 74
                                                                                                                                                            • Sodium depletion
                                                                                                                                                            • Sodium dilution
                                                                                                                                                            • Sign and symptoms
                                                                                                                                                            • Slide 78
                                                                                                                                                            • Treatment
                                                                                                                                                            • Slide 80
                                                                                                                                                            • Slide 81
                                                                                                                                                            • Dose
                                                                                                                                                            • Potassium abnormalities
                                                                                                                                                            • Hyperkalemia
                                                                                                                                                            • Clinical manifestation of hyperkalemia
                                                                                                                                                            • Slide 86
                                                                                                                                                            • Slide 87
                                                                                                                                                            • Hypokalemia
                                                                                                                                                            • Potassium changes associated with alkalosis
                                                                                                                                                            • Slide 90
                                                                                                                                                            • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                            • Slide 92
                                                                                                                                                            • Calcium
                                                                                                                                                            • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                            • علائم هیپوکلسمی
                                                                                                                                                            • Slide 96
                                                                                                                                                            • Slide 97
                                                                                                                                                            • Slide 98
                                                                                                                                                            • Slide 99
                                                                                                                                                            • سایرعلائم
                                                                                                                                                            • درمان
                                                                                                                                                            • هيپركلسمي Cagt55meql
                                                                                                                                                            • علائم
                                                                                                                                                            • علائم قلبی
                                                                                                                                                            • Slide 105
                                                                                                                                                            • Magnesium Abnormalities
                                                                                                                                                            • منیزیوم
                                                                                                                                                            • Hypermagnesemia
                                                                                                                                                            • Clinical manifestation hypermanesemia
                                                                                                                                                            • Slide 110
                                                                                                                                                            • Slide 111
                                                                                                                                                            • Hypomagnesemia
                                                                                                                                                            • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                            • Slide 114
                                                                                                                                                            • Message for Today
                                                                                                                                                            • Slide 116

                                                                                                                                                              Treatment

                                                                                                                                                              1 Asymptomatic increase the sodium level by no more than

                                                                                                                                                              05-1 meqLh to a maximum increase of 12 meqL per day

                                                                                                                                                              2 Symptomatic (Nalt120 meqL) Increase the sodium level by no

                                                                                                                                                              more than 1meqL per hour until the serum Na level reaches 130

                                                                                                                                                              meqL or neurologic symptoms are improved

                                                                                                                                                              Rapid correction of hyponatremia

                                                                                                                                                              Pontine myelinolysis

                                                                                                                                                              Seizures weaknessparesis akinetic

                                                                                                                                                              movements unresponsiveness

                                                                                                                                                              Permanent brain damage

                                                                                                                                                              Death

                                                                                                                                                              Dose

                                                                                                                                                              Na deficit meq =(140- Na meql) TBW

                                                                                                                                                              باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                                                              شود اصالح آهسته سپس

                                                                                                                                                              Potassium abnormalities

                                                                                                                                                              bull The average dietary intake of potassium 50-100meqd

                                                                                                                                                              bull The average renal excretion of potassium 10-700 meqd

                                                                                                                                                              - 2 of the total body potassium in ECF (45meqL)

                                                                                                                                                              - Factors that influence serum potassium

                                                                                                                                                              1 Surgical stress

                                                                                                                                                              2 Injury

                                                                                                                                                              3 Acidosis

                                                                                                                                                              4 Tissue catabolism

                                                                                                                                                              Hyperkalemia

                                                                                                                                                              The normal range of serum potassium 35-5 meqL

                                                                                                                                                              Etiology of Hyperkalemia

                                                                                                                                                              Increased intake Potassium supplementation

                                                                                                                                                              Blood transfusions

                                                                                                                                                              Endogenous loaddestruction

                                                                                                                                                              hemolysis rhabdomyolysis

                                                                                                                                                              cruch injury gastrointestinal hemorrhage

                                                                                                                                                              Increased release Acidosis

                                                                                                                                                              Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                                              Renal insufficiencyfailure

                                                                                                                                                              Clinical manifestation of hyperkalemia

                                                                                                                                                              System hyperkalemia

                                                                                                                                                              Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                                              Neuromuscular weakness paralysis respiratory failure

                                                                                                                                                              Cardiovascular Arrhythmia arrest

                                                                                                                                                              ECG changes Peaked T waves (early change)

                                                                                                                                                              Flattened P wave

                                                                                                                                                              Prolonged PR interval (first-degree block)

                                                                                                                                                              Widened QRS complex

                                                                                                                                                              Sine wave formation

                                                                                                                                                              Ventricular fibrillation

                                                                                                                                                              Treatment

                                                                                                                                                              Treatment of symptomatic hyperkalemia

                                                                                                                                                              Potassium removal Kayexalate

                                                                                                                                                              Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                                              Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                                              Dialysis

                                                                                                                                                              Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                                              Bicarbonate 1 vial intravenous

                                                                                                                                                              Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                                              HypokalemiaEtiology

                                                                                                                                                              inadequate intake

                                                                                                                                                              Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                                              total parenteral nutrition

                                                                                                                                                              Excessive potassium excretion

                                                                                                                                                              Hyperaldosteronism

                                                                                                                                                              Medications

                                                                                                                                                              Gastrointestinal losses

                                                                                                                                                              Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                                              Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                                              nasogastric output)

                                                                                                                                                              Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                                              Potassium changes associated with alkalosis

                                                                                                                                                              Potassium decrease by 03 meqL for every 01

                                                                                                                                                              increase in PH above normal

                                                                                                                                                              Magnesium Depletion

                                                                                                                                                              (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                              Renal potassium wastage

                                                                                                                                                              Hypokalemia

                                                                                                                                                              Magnesium Depletion

                                                                                                                                                              (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                              Renal potassium wastage

                                                                                                                                                              Hypokalemia

                                                                                                                                                              Clinical Manifestation of Abnormalities in potassium

                                                                                                                                                              System hypokalemia

                                                                                                                                                              Gastrointestinal Ileus constipation

                                                                                                                                                              Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                                              paralysis

                                                                                                                                                              Cardiovascular Arrest

                                                                                                                                                              ECG changes U-waves

                                                                                                                                                              T-wave flattening

                                                                                                                                                              ST-segment changes

                                                                                                                                                              Arrhythmias

                                                                                                                                                              Treatment

                                                                                                                                                              Potassium

                                                                                                                                                              Serum potassium level lt40 mEqL

                                                                                                                                                              Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                                              times 1 doses

                                                                                                                                                              Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                                              Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                                              Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                                              asymptomatic replace as per above protocol

                                                                                                                                                              Electrolyte Replacement Therapy Protocol

                                                                                                                                                              bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                                              bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                                              Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                              ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                              عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                              صاف 2 عضالت انقباض

                                                                                                                                                              هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                              انعقاد 4

                                                                                                                                                              یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                              عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                              ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                              میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                              ( شود می پیوند شده

                                                                                                                                                              هیپوکلسمی عالئم

                                                                                                                                                              رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                              سایرعالئم

                                                                                                                                                              قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                              درمان

                                                                                                                                                              ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                              Cagt55meql هيپركلسمي

                                                                                                                                                              هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                              عالئم

                                                                                                                                                              bullGI

                                                                                                                                                              bullCardiovascular bullRenal (polyuria)

                                                                                                                                                              bullCNS

                                                                                                                                                              قلبی عالئم

                                                                                                                                                              bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                              QRS شدن )Q-Tوكوتاه

                                                                                                                                                              درمان

                                                                                                                                                              ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                              الزیکس2

                                                                                                                                                              تونین 3 کلسی

                                                                                                                                                              کورتون4

                                                                                                                                                              دیالیز5

                                                                                                                                                              Magnesium Abnormalities

                                                                                                                                                              Normal dietary intake 20meq (240mg)

                                                                                                                                                              Excretion in both the feces and urine

                                                                                                                                                              Normal serum level 19-25 mgdL

                                                                                                                                                              منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                              تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                              bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                              Hypermagnesemia

                                                                                                                                                              Etiology

                                                                                                                                                              1 Impaired renal function

                                                                                                                                                              2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                              Clinical manifestation hypermanesemia

                                                                                                                                                              System hypermanesemia

                                                                                                                                                              Gastrointestinal Nauseavomiting

                                                                                                                                                              Neuromuscular weakness lethargy Decreased

                                                                                                                                                              reflexes

                                                                                                                                                              Cardiovascular Hypotension arrest

                                                                                                                                                              ECG changes Increased PR interval

                                                                                                                                                              Widened QRS complex

                                                                                                                                                              Elevated T waves

                                                                                                                                                              Treatment

                                                                                                                                                              1 Withhold exogenous sources of magnesium

                                                                                                                                                              2 Correct volume deficit

                                                                                                                                                              3 Correct acidosis if present

                                                                                                                                                              4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                              5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                              عالئم

                                                                                                                                                              bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                              meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                              meqL

                                                                                                                                                              Hypomagnesemia

                                                                                                                                                              Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                              homeostasis

                                                                                                                                                              Etiology

                                                                                                                                                              1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                              inadequate supplementation of magnesium)

                                                                                                                                                              2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                              3 GI losses (diarrhea)

                                                                                                                                                              4 Malabsorption

                                                                                                                                                              5 Acute pancreatitis

                                                                                                                                                              6 Diabetic ketoacidosis

                                                                                                                                                              7 Primary aldosteronism

                                                                                                                                                              Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                              1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                              2 Delirium and seizures in severe deficiency

                                                                                                                                                              3 ECG changes Prolonged QT and PR interval

                                                                                                                                                              ST-segment depression

                                                                                                                                                              Flattening or inversion of P waves

                                                                                                                                                              Torsades de pointes

                                                                                                                                                              Arrhythmia

                                                                                                                                                              Treatment

                                                                                                                                                              1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                              2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                              Message for Today

                                                                                                                                                              ICF

                                                                                                                                                              Interstitial

                                                                                                                                                              Pla

                                                                                                                                                              sma

                                                                                                                                                              5 Dex

                                                                                                                                                              bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                              • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                              • Slide 2
                                                                                                                                                              • Slide 3
                                                                                                                                                              • Slide 4
                                                                                                                                                              • Total Body Water
                                                                                                                                                              • Body Fluid Compartments
                                                                                                                                                              • Total body water (TBW)
                                                                                                                                                              • Body compartment fluid
                                                                                                                                                              • Example men with 70kg
                                                                                                                                                              • Fluid compartments
                                                                                                                                                              • Slide 11
                                                                                                                                                              • Slide 12
                                                                                                                                                              • Slide 13
                                                                                                                                                              • Slide 14
                                                                                                                                                              • Slide 15
                                                                                                                                                              • Colloid osmotic pressure
                                                                                                                                                              • Slide 17
                                                                                                                                                              • Slide 18
                                                                                                                                                              • Slide 19
                                                                                                                                                              • Cell Membrane
                                                                                                                                                              • Slide 21
                                                                                                                                                              • Slide 22
                                                                                                                                                              • Slide 23
                                                                                                                                                              • Slide 24
                                                                                                                                                              • Slide 25
                                                                                                                                                              • Composition of Fluid Compartments
                                                                                                                                                              • Composition of Body Fluids
                                                                                                                                                              • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                              • Reasons for fluid therapy
                                                                                                                                                              • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                              • محلولهای وریدی
                                                                                                                                                              • Fluids
                                                                                                                                                              • Slide 33
                                                                                                                                                              • Slide 34
                                                                                                                                                              • Slide 35
                                                                                                                                                              • Crystalloids
                                                                                                                                                              • Colloid Solutions
                                                                                                                                                              • رینگر لاکتات
                                                                                                                                                              • 09Nacl
                                                                                                                                                              • Postoperative (maintenance)
                                                                                                                                                              • Slide 41
                                                                                                                                                              • Preexisting fluid deficits
                                                                                                                                                              • Maintenance requirements
                                                                                                                                                              • Surgical fluid losses
                                                                                                                                                              • Third space loss
                                                                                                                                                              • Crystalloid solution
                                                                                                                                                              • Colloids
                                                                                                                                                              • Complications
                                                                                                                                                              • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                              • Colloid versus crystalloid solutions
                                                                                                                                                              • Transfusion consideration
                                                                                                                                                              • اختلال در حجم مایعات بدن
                                                                                                                                                              • Fluid volume deficit (FVD)
                                                                                                                                                              • DEHYDRATION
                                                                                                                                                              • علل کاهش حجم خارج سلولی
                                                                                                                                                              • Signs of Hypovolemia
                                                                                                                                                              • Clinical Diagnosis of Hypovolemia
                                                                                                                                                              • Signs of Hypervolemia
                                                                                                                                                              • Management of Hypervolemia
                                                                                                                                                              • Fluid Management
                                                                                                                                                              • Electrolyte physiology
                                                                                                                                                              • Sodium physiology
                                                                                                                                                              • Osmotic Pressure
                                                                                                                                                              • Concentration
                                                                                                                                                              • Hypernatremia
                                                                                                                                                              • - Hypernatremia
                                                                                                                                                              • Slide 67
                                                                                                                                                              • Slide 68
                                                                                                                                                              • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                              • Treatment
                                                                                                                                                              • Water deficit (L)= times TBW
                                                                                                                                                              • The rate of fluid administration
                                                                                                                                                              • Hyponatremia Nalt135mEqL
                                                                                                                                                              • Slide 74
                                                                                                                                                              • Sodium depletion
                                                                                                                                                              • Sodium dilution
                                                                                                                                                              • Sign and symptoms
                                                                                                                                                              • Slide 78
                                                                                                                                                              • Treatment
                                                                                                                                                              • Slide 80
                                                                                                                                                              • Slide 81
                                                                                                                                                              • Dose
                                                                                                                                                              • Potassium abnormalities
                                                                                                                                                              • Hyperkalemia
                                                                                                                                                              • Clinical manifestation of hyperkalemia
                                                                                                                                                              • Slide 86
                                                                                                                                                              • Slide 87
                                                                                                                                                              • Hypokalemia
                                                                                                                                                              • Potassium changes associated with alkalosis
                                                                                                                                                              • Slide 90
                                                                                                                                                              • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                              • Slide 92
                                                                                                                                                              • Calcium
                                                                                                                                                              • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                              • علائم هیپوکلسمی
                                                                                                                                                              • Slide 96
                                                                                                                                                              • Slide 97
                                                                                                                                                              • Slide 98
                                                                                                                                                              • Slide 99
                                                                                                                                                              • سایرعلائم
                                                                                                                                                              • درمان
                                                                                                                                                              • هيپركلسمي Cagt55meql
                                                                                                                                                              • علائم
                                                                                                                                                              • علائم قلبی
                                                                                                                                                              • Slide 105
                                                                                                                                                              • Magnesium Abnormalities
                                                                                                                                                              • منیزیوم
                                                                                                                                                              • Hypermagnesemia
                                                                                                                                                              • Clinical manifestation hypermanesemia
                                                                                                                                                              • Slide 110
                                                                                                                                                              • Slide 111
                                                                                                                                                              • Hypomagnesemia
                                                                                                                                                              • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                              • Slide 114
                                                                                                                                                              • Message for Today
                                                                                                                                                              • Slide 116

                                                                                                                                                                Rapid correction of hyponatremia

                                                                                                                                                                Pontine myelinolysis

                                                                                                                                                                Seizures weaknessparesis akinetic

                                                                                                                                                                movements unresponsiveness

                                                                                                                                                                Permanent brain damage

                                                                                                                                                                Death

                                                                                                                                                                Dose

                                                                                                                                                                Na deficit meq =(140- Na meql) TBW

                                                                                                                                                                باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                                                                شود اصالح آهسته سپس

                                                                                                                                                                Potassium abnormalities

                                                                                                                                                                bull The average dietary intake of potassium 50-100meqd

                                                                                                                                                                bull The average renal excretion of potassium 10-700 meqd

                                                                                                                                                                - 2 of the total body potassium in ECF (45meqL)

                                                                                                                                                                - Factors that influence serum potassium

                                                                                                                                                                1 Surgical stress

                                                                                                                                                                2 Injury

                                                                                                                                                                3 Acidosis

                                                                                                                                                                4 Tissue catabolism

                                                                                                                                                                Hyperkalemia

                                                                                                                                                                The normal range of serum potassium 35-5 meqL

                                                                                                                                                                Etiology of Hyperkalemia

                                                                                                                                                                Increased intake Potassium supplementation

                                                                                                                                                                Blood transfusions

                                                                                                                                                                Endogenous loaddestruction

                                                                                                                                                                hemolysis rhabdomyolysis

                                                                                                                                                                cruch injury gastrointestinal hemorrhage

                                                                                                                                                                Increased release Acidosis

                                                                                                                                                                Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                                                Renal insufficiencyfailure

                                                                                                                                                                Clinical manifestation of hyperkalemia

                                                                                                                                                                System hyperkalemia

                                                                                                                                                                Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                                                Neuromuscular weakness paralysis respiratory failure

                                                                                                                                                                Cardiovascular Arrhythmia arrest

                                                                                                                                                                ECG changes Peaked T waves (early change)

                                                                                                                                                                Flattened P wave

                                                                                                                                                                Prolonged PR interval (first-degree block)

                                                                                                                                                                Widened QRS complex

                                                                                                                                                                Sine wave formation

                                                                                                                                                                Ventricular fibrillation

                                                                                                                                                                Treatment

                                                                                                                                                                Treatment of symptomatic hyperkalemia

                                                                                                                                                                Potassium removal Kayexalate

                                                                                                                                                                Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                                                Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                                                Dialysis

                                                                                                                                                                Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                                                Bicarbonate 1 vial intravenous

                                                                                                                                                                Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                                                HypokalemiaEtiology

                                                                                                                                                                inadequate intake

                                                                                                                                                                Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                                                total parenteral nutrition

                                                                                                                                                                Excessive potassium excretion

                                                                                                                                                                Hyperaldosteronism

                                                                                                                                                                Medications

                                                                                                                                                                Gastrointestinal losses

                                                                                                                                                                Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                                                Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                                                nasogastric output)

                                                                                                                                                                Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                                                Potassium changes associated with alkalosis

                                                                                                                                                                Potassium decrease by 03 meqL for every 01

                                                                                                                                                                increase in PH above normal

                                                                                                                                                                Magnesium Depletion

                                                                                                                                                                (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                                Renal potassium wastage

                                                                                                                                                                Hypokalemia

                                                                                                                                                                Magnesium Depletion

                                                                                                                                                                (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                                Renal potassium wastage

                                                                                                                                                                Hypokalemia

                                                                                                                                                                Clinical Manifestation of Abnormalities in potassium

                                                                                                                                                                System hypokalemia

                                                                                                                                                                Gastrointestinal Ileus constipation

                                                                                                                                                                Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                                                paralysis

                                                                                                                                                                Cardiovascular Arrest

                                                                                                                                                                ECG changes U-waves

                                                                                                                                                                T-wave flattening

                                                                                                                                                                ST-segment changes

                                                                                                                                                                Arrhythmias

                                                                                                                                                                Treatment

                                                                                                                                                                Potassium

                                                                                                                                                                Serum potassium level lt40 mEqL

                                                                                                                                                                Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                                                times 1 doses

                                                                                                                                                                Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                                                Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                                                Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                                                asymptomatic replace as per above protocol

                                                                                                                                                                Electrolyte Replacement Therapy Protocol

                                                                                                                                                                bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                                                bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                                                Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                                ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                                عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                                صاف 2 عضالت انقباض

                                                                                                                                                                هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                                انعقاد 4

                                                                                                                                                                یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                                عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                                ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                                میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                                ( شود می پیوند شده

                                                                                                                                                                هیپوکلسمی عالئم

                                                                                                                                                                رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                                سایرعالئم

                                                                                                                                                                قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                                درمان

                                                                                                                                                                ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                                Cagt55meql هيپركلسمي

                                                                                                                                                                هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                                عالئم

                                                                                                                                                                bullGI

                                                                                                                                                                bullCardiovascular bullRenal (polyuria)

                                                                                                                                                                bullCNS

                                                                                                                                                                قلبی عالئم

                                                                                                                                                                bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                                QRS شدن )Q-Tوكوتاه

                                                                                                                                                                درمان

                                                                                                                                                                ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                الزیکس2

                                                                                                                                                                تونین 3 کلسی

                                                                                                                                                                کورتون4

                                                                                                                                                                دیالیز5

                                                                                                                                                                Magnesium Abnormalities

                                                                                                                                                                Normal dietary intake 20meq (240mg)

                                                                                                                                                                Excretion in both the feces and urine

                                                                                                                                                                Normal serum level 19-25 mgdL

                                                                                                                                                                منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                Hypermagnesemia

                                                                                                                                                                Etiology

                                                                                                                                                                1 Impaired renal function

                                                                                                                                                                2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                Clinical manifestation hypermanesemia

                                                                                                                                                                System hypermanesemia

                                                                                                                                                                Gastrointestinal Nauseavomiting

                                                                                                                                                                Neuromuscular weakness lethargy Decreased

                                                                                                                                                                reflexes

                                                                                                                                                                Cardiovascular Hypotension arrest

                                                                                                                                                                ECG changes Increased PR interval

                                                                                                                                                                Widened QRS complex

                                                                                                                                                                Elevated T waves

                                                                                                                                                                Treatment

                                                                                                                                                                1 Withhold exogenous sources of magnesium

                                                                                                                                                                2 Correct volume deficit

                                                                                                                                                                3 Correct acidosis if present

                                                                                                                                                                4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                عالئم

                                                                                                                                                                bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                meqL

                                                                                                                                                                Hypomagnesemia

                                                                                                                                                                Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                homeostasis

                                                                                                                                                                Etiology

                                                                                                                                                                1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                inadequate supplementation of magnesium)

                                                                                                                                                                2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                3 GI losses (diarrhea)

                                                                                                                                                                4 Malabsorption

                                                                                                                                                                5 Acute pancreatitis

                                                                                                                                                                6 Diabetic ketoacidosis

                                                                                                                                                                7 Primary aldosteronism

                                                                                                                                                                Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                2 Delirium and seizures in severe deficiency

                                                                                                                                                                3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                ST-segment depression

                                                                                                                                                                Flattening or inversion of P waves

                                                                                                                                                                Torsades de pointes

                                                                                                                                                                Arrhythmia

                                                                                                                                                                Treatment

                                                                                                                                                                1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                Message for Today

                                                                                                                                                                ICF

                                                                                                                                                                Interstitial

                                                                                                                                                                Pla

                                                                                                                                                                sma

                                                                                                                                                                5 Dex

                                                                                                                                                                bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                • Slide 2
                                                                                                                                                                • Slide 3
                                                                                                                                                                • Slide 4
                                                                                                                                                                • Total Body Water
                                                                                                                                                                • Body Fluid Compartments
                                                                                                                                                                • Total body water (TBW)
                                                                                                                                                                • Body compartment fluid
                                                                                                                                                                • Example men with 70kg
                                                                                                                                                                • Fluid compartments
                                                                                                                                                                • Slide 11
                                                                                                                                                                • Slide 12
                                                                                                                                                                • Slide 13
                                                                                                                                                                • Slide 14
                                                                                                                                                                • Slide 15
                                                                                                                                                                • Colloid osmotic pressure
                                                                                                                                                                • Slide 17
                                                                                                                                                                • Slide 18
                                                                                                                                                                • Slide 19
                                                                                                                                                                • Cell Membrane
                                                                                                                                                                • Slide 21
                                                                                                                                                                • Slide 22
                                                                                                                                                                • Slide 23
                                                                                                                                                                • Slide 24
                                                                                                                                                                • Slide 25
                                                                                                                                                                • Composition of Fluid Compartments
                                                                                                                                                                • Composition of Body Fluids
                                                                                                                                                                • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                • Reasons for fluid therapy
                                                                                                                                                                • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                • محلولهای وریدی
                                                                                                                                                                • Fluids
                                                                                                                                                                • Slide 33
                                                                                                                                                                • Slide 34
                                                                                                                                                                • Slide 35
                                                                                                                                                                • Crystalloids
                                                                                                                                                                • Colloid Solutions
                                                                                                                                                                • رینگر لاکتات
                                                                                                                                                                • 09Nacl
                                                                                                                                                                • Postoperative (maintenance)
                                                                                                                                                                • Slide 41
                                                                                                                                                                • Preexisting fluid deficits
                                                                                                                                                                • Maintenance requirements
                                                                                                                                                                • Surgical fluid losses
                                                                                                                                                                • Third space loss
                                                                                                                                                                • Crystalloid solution
                                                                                                                                                                • Colloids
                                                                                                                                                                • Complications
                                                                                                                                                                • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                • Colloid versus crystalloid solutions
                                                                                                                                                                • Transfusion consideration
                                                                                                                                                                • اختلال در حجم مایعات بدن
                                                                                                                                                                • Fluid volume deficit (FVD)
                                                                                                                                                                • DEHYDRATION
                                                                                                                                                                • علل کاهش حجم خارج سلولی
                                                                                                                                                                • Signs of Hypovolemia
                                                                                                                                                                • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                • Signs of Hypervolemia
                                                                                                                                                                • Management of Hypervolemia
                                                                                                                                                                • Fluid Management
                                                                                                                                                                • Electrolyte physiology
                                                                                                                                                                • Sodium physiology
                                                                                                                                                                • Osmotic Pressure
                                                                                                                                                                • Concentration
                                                                                                                                                                • Hypernatremia
                                                                                                                                                                • - Hypernatremia
                                                                                                                                                                • Slide 67
                                                                                                                                                                • Slide 68
                                                                                                                                                                • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                • Treatment
                                                                                                                                                                • Water deficit (L)= times TBW
                                                                                                                                                                • The rate of fluid administration
                                                                                                                                                                • Hyponatremia Nalt135mEqL
                                                                                                                                                                • Slide 74
                                                                                                                                                                • Sodium depletion
                                                                                                                                                                • Sodium dilution
                                                                                                                                                                • Sign and symptoms
                                                                                                                                                                • Slide 78
                                                                                                                                                                • Treatment
                                                                                                                                                                • Slide 80
                                                                                                                                                                • Slide 81
                                                                                                                                                                • Dose
                                                                                                                                                                • Potassium abnormalities
                                                                                                                                                                • Hyperkalemia
                                                                                                                                                                • Clinical manifestation of hyperkalemia
                                                                                                                                                                • Slide 86
                                                                                                                                                                • Slide 87
                                                                                                                                                                • Hypokalemia
                                                                                                                                                                • Potassium changes associated with alkalosis
                                                                                                                                                                • Slide 90
                                                                                                                                                                • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                • Slide 92
                                                                                                                                                                • Calcium
                                                                                                                                                                • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                • علائم هیپوکلسمی
                                                                                                                                                                • Slide 96
                                                                                                                                                                • Slide 97
                                                                                                                                                                • Slide 98
                                                                                                                                                                • Slide 99
                                                                                                                                                                • سایرعلائم
                                                                                                                                                                • درمان
                                                                                                                                                                • هيپركلسمي Cagt55meql
                                                                                                                                                                • علائم
                                                                                                                                                                • علائم قلبی
                                                                                                                                                                • Slide 105
                                                                                                                                                                • Magnesium Abnormalities
                                                                                                                                                                • منیزیوم
                                                                                                                                                                • Hypermagnesemia
                                                                                                                                                                • Clinical manifestation hypermanesemia
                                                                                                                                                                • Slide 110
                                                                                                                                                                • Slide 111
                                                                                                                                                                • Hypomagnesemia
                                                                                                                                                                • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                • Slide 114
                                                                                                                                                                • Message for Today
                                                                                                                                                                • Slide 116

                                                                                                                                                                  Dose

                                                                                                                                                                  Na deficit meq =(140- Na meql) TBW

                                                                                                                                                                  باید به h 05-1 meqlاصالح سدیم تا و 125meqlباشد برسد

                                                                                                                                                                  شود اصالح آهسته سپس

                                                                                                                                                                  Potassium abnormalities

                                                                                                                                                                  bull The average dietary intake of potassium 50-100meqd

                                                                                                                                                                  bull The average renal excretion of potassium 10-700 meqd

                                                                                                                                                                  - 2 of the total body potassium in ECF (45meqL)

                                                                                                                                                                  - Factors that influence serum potassium

                                                                                                                                                                  1 Surgical stress

                                                                                                                                                                  2 Injury

                                                                                                                                                                  3 Acidosis

                                                                                                                                                                  4 Tissue catabolism

                                                                                                                                                                  Hyperkalemia

                                                                                                                                                                  The normal range of serum potassium 35-5 meqL

                                                                                                                                                                  Etiology of Hyperkalemia

                                                                                                                                                                  Increased intake Potassium supplementation

                                                                                                                                                                  Blood transfusions

                                                                                                                                                                  Endogenous loaddestruction

                                                                                                                                                                  hemolysis rhabdomyolysis

                                                                                                                                                                  cruch injury gastrointestinal hemorrhage

                                                                                                                                                                  Increased release Acidosis

                                                                                                                                                                  Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                                                  Renal insufficiencyfailure

                                                                                                                                                                  Clinical manifestation of hyperkalemia

                                                                                                                                                                  System hyperkalemia

                                                                                                                                                                  Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                                                  Neuromuscular weakness paralysis respiratory failure

                                                                                                                                                                  Cardiovascular Arrhythmia arrest

                                                                                                                                                                  ECG changes Peaked T waves (early change)

                                                                                                                                                                  Flattened P wave

                                                                                                                                                                  Prolonged PR interval (first-degree block)

                                                                                                                                                                  Widened QRS complex

                                                                                                                                                                  Sine wave formation

                                                                                                                                                                  Ventricular fibrillation

                                                                                                                                                                  Treatment

                                                                                                                                                                  Treatment of symptomatic hyperkalemia

                                                                                                                                                                  Potassium removal Kayexalate

                                                                                                                                                                  Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                                                  Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                                                  Dialysis

                                                                                                                                                                  Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                                                  Bicarbonate 1 vial intravenous

                                                                                                                                                                  Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                                                  HypokalemiaEtiology

                                                                                                                                                                  inadequate intake

                                                                                                                                                                  Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                                                  total parenteral nutrition

                                                                                                                                                                  Excessive potassium excretion

                                                                                                                                                                  Hyperaldosteronism

                                                                                                                                                                  Medications

                                                                                                                                                                  Gastrointestinal losses

                                                                                                                                                                  Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                                                  Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                                                  nasogastric output)

                                                                                                                                                                  Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                                                  Potassium changes associated with alkalosis

                                                                                                                                                                  Potassium decrease by 03 meqL for every 01

                                                                                                                                                                  increase in PH above normal

                                                                                                                                                                  Magnesium Depletion

                                                                                                                                                                  (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                                  Renal potassium wastage

                                                                                                                                                                  Hypokalemia

                                                                                                                                                                  Magnesium Depletion

                                                                                                                                                                  (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                                  Renal potassium wastage

                                                                                                                                                                  Hypokalemia

                                                                                                                                                                  Clinical Manifestation of Abnormalities in potassium

                                                                                                                                                                  System hypokalemia

                                                                                                                                                                  Gastrointestinal Ileus constipation

                                                                                                                                                                  Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                                                  paralysis

                                                                                                                                                                  Cardiovascular Arrest

                                                                                                                                                                  ECG changes U-waves

                                                                                                                                                                  T-wave flattening

                                                                                                                                                                  ST-segment changes

                                                                                                                                                                  Arrhythmias

                                                                                                                                                                  Treatment

                                                                                                                                                                  Potassium

                                                                                                                                                                  Serum potassium level lt40 mEqL

                                                                                                                                                                  Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                                                  times 1 doses

                                                                                                                                                                  Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                                                  Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                                                  Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                                                  asymptomatic replace as per above protocol

                                                                                                                                                                  Electrolyte Replacement Therapy Protocol

                                                                                                                                                                  bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                                                  bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                                                  Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                                  ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                                  عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                                  صاف 2 عضالت انقباض

                                                                                                                                                                  هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                                  انعقاد 4

                                                                                                                                                                  یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                                  عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                                  ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                                  میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                                  ( شود می پیوند شده

                                                                                                                                                                  هیپوکلسمی عالئم

                                                                                                                                                                  رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                                  سایرعالئم

                                                                                                                                                                  قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                                  درمان

                                                                                                                                                                  ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                                  Cagt55meql هيپركلسمي

                                                                                                                                                                  هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                                  عالئم

                                                                                                                                                                  bullGI

                                                                                                                                                                  bullCardiovascular bullRenal (polyuria)

                                                                                                                                                                  bullCNS

                                                                                                                                                                  قلبی عالئم

                                                                                                                                                                  bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                                  QRS شدن )Q-Tوكوتاه

                                                                                                                                                                  درمان

                                                                                                                                                                  ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                  الزیکس2

                                                                                                                                                                  تونین 3 کلسی

                                                                                                                                                                  کورتون4

                                                                                                                                                                  دیالیز5

                                                                                                                                                                  Magnesium Abnormalities

                                                                                                                                                                  Normal dietary intake 20meq (240mg)

                                                                                                                                                                  Excretion in both the feces and urine

                                                                                                                                                                  Normal serum level 19-25 mgdL

                                                                                                                                                                  منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                  تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                  bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                  Hypermagnesemia

                                                                                                                                                                  Etiology

                                                                                                                                                                  1 Impaired renal function

                                                                                                                                                                  2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                  Clinical manifestation hypermanesemia

                                                                                                                                                                  System hypermanesemia

                                                                                                                                                                  Gastrointestinal Nauseavomiting

                                                                                                                                                                  Neuromuscular weakness lethargy Decreased

                                                                                                                                                                  reflexes

                                                                                                                                                                  Cardiovascular Hypotension arrest

                                                                                                                                                                  ECG changes Increased PR interval

                                                                                                                                                                  Widened QRS complex

                                                                                                                                                                  Elevated T waves

                                                                                                                                                                  Treatment

                                                                                                                                                                  1 Withhold exogenous sources of magnesium

                                                                                                                                                                  2 Correct volume deficit

                                                                                                                                                                  3 Correct acidosis if present

                                                                                                                                                                  4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                  5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                  عالئم

                                                                                                                                                                  bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                  meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                  meqL

                                                                                                                                                                  Hypomagnesemia

                                                                                                                                                                  Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                  homeostasis

                                                                                                                                                                  Etiology

                                                                                                                                                                  1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                  inadequate supplementation of magnesium)

                                                                                                                                                                  2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                  3 GI losses (diarrhea)

                                                                                                                                                                  4 Malabsorption

                                                                                                                                                                  5 Acute pancreatitis

                                                                                                                                                                  6 Diabetic ketoacidosis

                                                                                                                                                                  7 Primary aldosteronism

                                                                                                                                                                  Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                  1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                  2 Delirium and seizures in severe deficiency

                                                                                                                                                                  3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                  ST-segment depression

                                                                                                                                                                  Flattening or inversion of P waves

                                                                                                                                                                  Torsades de pointes

                                                                                                                                                                  Arrhythmia

                                                                                                                                                                  Treatment

                                                                                                                                                                  1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                  2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                  Message for Today

                                                                                                                                                                  ICF

                                                                                                                                                                  Interstitial

                                                                                                                                                                  Pla

                                                                                                                                                                  sma

                                                                                                                                                                  5 Dex

                                                                                                                                                                  bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                  • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                  • Slide 2
                                                                                                                                                                  • Slide 3
                                                                                                                                                                  • Slide 4
                                                                                                                                                                  • Total Body Water
                                                                                                                                                                  • Body Fluid Compartments
                                                                                                                                                                  • Total body water (TBW)
                                                                                                                                                                  • Body compartment fluid
                                                                                                                                                                  • Example men with 70kg
                                                                                                                                                                  • Fluid compartments
                                                                                                                                                                  • Slide 11
                                                                                                                                                                  • Slide 12
                                                                                                                                                                  • Slide 13
                                                                                                                                                                  • Slide 14
                                                                                                                                                                  • Slide 15
                                                                                                                                                                  • Colloid osmotic pressure
                                                                                                                                                                  • Slide 17
                                                                                                                                                                  • Slide 18
                                                                                                                                                                  • Slide 19
                                                                                                                                                                  • Cell Membrane
                                                                                                                                                                  • Slide 21
                                                                                                                                                                  • Slide 22
                                                                                                                                                                  • Slide 23
                                                                                                                                                                  • Slide 24
                                                                                                                                                                  • Slide 25
                                                                                                                                                                  • Composition of Fluid Compartments
                                                                                                                                                                  • Composition of Body Fluids
                                                                                                                                                                  • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                  • Reasons for fluid therapy
                                                                                                                                                                  • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                  • محلولهای وریدی
                                                                                                                                                                  • Fluids
                                                                                                                                                                  • Slide 33
                                                                                                                                                                  • Slide 34
                                                                                                                                                                  • Slide 35
                                                                                                                                                                  • Crystalloids
                                                                                                                                                                  • Colloid Solutions
                                                                                                                                                                  • رینگر لاکتات
                                                                                                                                                                  • 09Nacl
                                                                                                                                                                  • Postoperative (maintenance)
                                                                                                                                                                  • Slide 41
                                                                                                                                                                  • Preexisting fluid deficits
                                                                                                                                                                  • Maintenance requirements
                                                                                                                                                                  • Surgical fluid losses
                                                                                                                                                                  • Third space loss
                                                                                                                                                                  • Crystalloid solution
                                                                                                                                                                  • Colloids
                                                                                                                                                                  • Complications
                                                                                                                                                                  • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                  • Colloid versus crystalloid solutions
                                                                                                                                                                  • Transfusion consideration
                                                                                                                                                                  • اختلال در حجم مایعات بدن
                                                                                                                                                                  • Fluid volume deficit (FVD)
                                                                                                                                                                  • DEHYDRATION
                                                                                                                                                                  • علل کاهش حجم خارج سلولی
                                                                                                                                                                  • Signs of Hypovolemia
                                                                                                                                                                  • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                  • Signs of Hypervolemia
                                                                                                                                                                  • Management of Hypervolemia
                                                                                                                                                                  • Fluid Management
                                                                                                                                                                  • Electrolyte physiology
                                                                                                                                                                  • Sodium physiology
                                                                                                                                                                  • Osmotic Pressure
                                                                                                                                                                  • Concentration
                                                                                                                                                                  • Hypernatremia
                                                                                                                                                                  • - Hypernatremia
                                                                                                                                                                  • Slide 67
                                                                                                                                                                  • Slide 68
                                                                                                                                                                  • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                  • Treatment
                                                                                                                                                                  • Water deficit (L)= times TBW
                                                                                                                                                                  • The rate of fluid administration
                                                                                                                                                                  • Hyponatremia Nalt135mEqL
                                                                                                                                                                  • Slide 74
                                                                                                                                                                  • Sodium depletion
                                                                                                                                                                  • Sodium dilution
                                                                                                                                                                  • Sign and symptoms
                                                                                                                                                                  • Slide 78
                                                                                                                                                                  • Treatment
                                                                                                                                                                  • Slide 80
                                                                                                                                                                  • Slide 81
                                                                                                                                                                  • Dose
                                                                                                                                                                  • Potassium abnormalities
                                                                                                                                                                  • Hyperkalemia
                                                                                                                                                                  • Clinical manifestation of hyperkalemia
                                                                                                                                                                  • Slide 86
                                                                                                                                                                  • Slide 87
                                                                                                                                                                  • Hypokalemia
                                                                                                                                                                  • Potassium changes associated with alkalosis
                                                                                                                                                                  • Slide 90
                                                                                                                                                                  • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                  • Slide 92
                                                                                                                                                                  • Calcium
                                                                                                                                                                  • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                  • علائم هیپوکلسمی
                                                                                                                                                                  • Slide 96
                                                                                                                                                                  • Slide 97
                                                                                                                                                                  • Slide 98
                                                                                                                                                                  • Slide 99
                                                                                                                                                                  • سایرعلائم
                                                                                                                                                                  • درمان
                                                                                                                                                                  • هيپركلسمي Cagt55meql
                                                                                                                                                                  • علائم
                                                                                                                                                                  • علائم قلبی
                                                                                                                                                                  • Slide 105
                                                                                                                                                                  • Magnesium Abnormalities
                                                                                                                                                                  • منیزیوم
                                                                                                                                                                  • Hypermagnesemia
                                                                                                                                                                  • Clinical manifestation hypermanesemia
                                                                                                                                                                  • Slide 110
                                                                                                                                                                  • Slide 111
                                                                                                                                                                  • Hypomagnesemia
                                                                                                                                                                  • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                  • Slide 114
                                                                                                                                                                  • Message for Today
                                                                                                                                                                  • Slide 116

                                                                                                                                                                    Potassium abnormalities

                                                                                                                                                                    bull The average dietary intake of potassium 50-100meqd

                                                                                                                                                                    bull The average renal excretion of potassium 10-700 meqd

                                                                                                                                                                    - 2 of the total body potassium in ECF (45meqL)

                                                                                                                                                                    - Factors that influence serum potassium

                                                                                                                                                                    1 Surgical stress

                                                                                                                                                                    2 Injury

                                                                                                                                                                    3 Acidosis

                                                                                                                                                                    4 Tissue catabolism

                                                                                                                                                                    Hyperkalemia

                                                                                                                                                                    The normal range of serum potassium 35-5 meqL

                                                                                                                                                                    Etiology of Hyperkalemia

                                                                                                                                                                    Increased intake Potassium supplementation

                                                                                                                                                                    Blood transfusions

                                                                                                                                                                    Endogenous loaddestruction

                                                                                                                                                                    hemolysis rhabdomyolysis

                                                                                                                                                                    cruch injury gastrointestinal hemorrhage

                                                                                                                                                                    Increased release Acidosis

                                                                                                                                                                    Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                                                    Renal insufficiencyfailure

                                                                                                                                                                    Clinical manifestation of hyperkalemia

                                                                                                                                                                    System hyperkalemia

                                                                                                                                                                    Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                                                    Neuromuscular weakness paralysis respiratory failure

                                                                                                                                                                    Cardiovascular Arrhythmia arrest

                                                                                                                                                                    ECG changes Peaked T waves (early change)

                                                                                                                                                                    Flattened P wave

                                                                                                                                                                    Prolonged PR interval (first-degree block)

                                                                                                                                                                    Widened QRS complex

                                                                                                                                                                    Sine wave formation

                                                                                                                                                                    Ventricular fibrillation

                                                                                                                                                                    Treatment

                                                                                                                                                                    Treatment of symptomatic hyperkalemia

                                                                                                                                                                    Potassium removal Kayexalate

                                                                                                                                                                    Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                                                    Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                                                    Dialysis

                                                                                                                                                                    Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                                                    Bicarbonate 1 vial intravenous

                                                                                                                                                                    Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                                                    HypokalemiaEtiology

                                                                                                                                                                    inadequate intake

                                                                                                                                                                    Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                                                    total parenteral nutrition

                                                                                                                                                                    Excessive potassium excretion

                                                                                                                                                                    Hyperaldosteronism

                                                                                                                                                                    Medications

                                                                                                                                                                    Gastrointestinal losses

                                                                                                                                                                    Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                                                    Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                                                    nasogastric output)

                                                                                                                                                                    Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                                                    Potassium changes associated with alkalosis

                                                                                                                                                                    Potassium decrease by 03 meqL for every 01

                                                                                                                                                                    increase in PH above normal

                                                                                                                                                                    Magnesium Depletion

                                                                                                                                                                    (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                                    Renal potassium wastage

                                                                                                                                                                    Hypokalemia

                                                                                                                                                                    Magnesium Depletion

                                                                                                                                                                    (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                                    Renal potassium wastage

                                                                                                                                                                    Hypokalemia

                                                                                                                                                                    Clinical Manifestation of Abnormalities in potassium

                                                                                                                                                                    System hypokalemia

                                                                                                                                                                    Gastrointestinal Ileus constipation

                                                                                                                                                                    Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                                                    paralysis

                                                                                                                                                                    Cardiovascular Arrest

                                                                                                                                                                    ECG changes U-waves

                                                                                                                                                                    T-wave flattening

                                                                                                                                                                    ST-segment changes

                                                                                                                                                                    Arrhythmias

                                                                                                                                                                    Treatment

                                                                                                                                                                    Potassium

                                                                                                                                                                    Serum potassium level lt40 mEqL

                                                                                                                                                                    Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                                                    times 1 doses

                                                                                                                                                                    Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                                                    Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                                                    Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                                                    asymptomatic replace as per above protocol

                                                                                                                                                                    Electrolyte Replacement Therapy Protocol

                                                                                                                                                                    bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                                                    bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                                                    Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                                    ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                                    عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                                    صاف 2 عضالت انقباض

                                                                                                                                                                    هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                                    انعقاد 4

                                                                                                                                                                    یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                                    عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                                    ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                                    میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                                    ( شود می پیوند شده

                                                                                                                                                                    هیپوکلسمی عالئم

                                                                                                                                                                    رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                                    سایرعالئم

                                                                                                                                                                    قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                                    درمان

                                                                                                                                                                    ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                                    Cagt55meql هيپركلسمي

                                                                                                                                                                    هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                                    عالئم

                                                                                                                                                                    bullGI

                                                                                                                                                                    bullCardiovascular bullRenal (polyuria)

                                                                                                                                                                    bullCNS

                                                                                                                                                                    قلبی عالئم

                                                                                                                                                                    bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                                    QRS شدن )Q-Tوكوتاه

                                                                                                                                                                    درمان

                                                                                                                                                                    ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                    الزیکس2

                                                                                                                                                                    تونین 3 کلسی

                                                                                                                                                                    کورتون4

                                                                                                                                                                    دیالیز5

                                                                                                                                                                    Magnesium Abnormalities

                                                                                                                                                                    Normal dietary intake 20meq (240mg)

                                                                                                                                                                    Excretion in both the feces and urine

                                                                                                                                                                    Normal serum level 19-25 mgdL

                                                                                                                                                                    منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                    تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                    bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                    Hypermagnesemia

                                                                                                                                                                    Etiology

                                                                                                                                                                    1 Impaired renal function

                                                                                                                                                                    2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                    Clinical manifestation hypermanesemia

                                                                                                                                                                    System hypermanesemia

                                                                                                                                                                    Gastrointestinal Nauseavomiting

                                                                                                                                                                    Neuromuscular weakness lethargy Decreased

                                                                                                                                                                    reflexes

                                                                                                                                                                    Cardiovascular Hypotension arrest

                                                                                                                                                                    ECG changes Increased PR interval

                                                                                                                                                                    Widened QRS complex

                                                                                                                                                                    Elevated T waves

                                                                                                                                                                    Treatment

                                                                                                                                                                    1 Withhold exogenous sources of magnesium

                                                                                                                                                                    2 Correct volume deficit

                                                                                                                                                                    3 Correct acidosis if present

                                                                                                                                                                    4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                    5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                    عالئم

                                                                                                                                                                    bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                    meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                    meqL

                                                                                                                                                                    Hypomagnesemia

                                                                                                                                                                    Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                    homeostasis

                                                                                                                                                                    Etiology

                                                                                                                                                                    1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                    inadequate supplementation of magnesium)

                                                                                                                                                                    2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                    3 GI losses (diarrhea)

                                                                                                                                                                    4 Malabsorption

                                                                                                                                                                    5 Acute pancreatitis

                                                                                                                                                                    6 Diabetic ketoacidosis

                                                                                                                                                                    7 Primary aldosteronism

                                                                                                                                                                    Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                    1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                    2 Delirium and seizures in severe deficiency

                                                                                                                                                                    3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                    ST-segment depression

                                                                                                                                                                    Flattening or inversion of P waves

                                                                                                                                                                    Torsades de pointes

                                                                                                                                                                    Arrhythmia

                                                                                                                                                                    Treatment

                                                                                                                                                                    1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                    2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                    Message for Today

                                                                                                                                                                    ICF

                                                                                                                                                                    Interstitial

                                                                                                                                                                    Pla

                                                                                                                                                                    sma

                                                                                                                                                                    5 Dex

                                                                                                                                                                    bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                    • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                    • Slide 2
                                                                                                                                                                    • Slide 3
                                                                                                                                                                    • Slide 4
                                                                                                                                                                    • Total Body Water
                                                                                                                                                                    • Body Fluid Compartments
                                                                                                                                                                    • Total body water (TBW)
                                                                                                                                                                    • Body compartment fluid
                                                                                                                                                                    • Example men with 70kg
                                                                                                                                                                    • Fluid compartments
                                                                                                                                                                    • Slide 11
                                                                                                                                                                    • Slide 12
                                                                                                                                                                    • Slide 13
                                                                                                                                                                    • Slide 14
                                                                                                                                                                    • Slide 15
                                                                                                                                                                    • Colloid osmotic pressure
                                                                                                                                                                    • Slide 17
                                                                                                                                                                    • Slide 18
                                                                                                                                                                    • Slide 19
                                                                                                                                                                    • Cell Membrane
                                                                                                                                                                    • Slide 21
                                                                                                                                                                    • Slide 22
                                                                                                                                                                    • Slide 23
                                                                                                                                                                    • Slide 24
                                                                                                                                                                    • Slide 25
                                                                                                                                                                    • Composition of Fluid Compartments
                                                                                                                                                                    • Composition of Body Fluids
                                                                                                                                                                    • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                    • Reasons for fluid therapy
                                                                                                                                                                    • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                    • محلولهای وریدی
                                                                                                                                                                    • Fluids
                                                                                                                                                                    • Slide 33
                                                                                                                                                                    • Slide 34
                                                                                                                                                                    • Slide 35
                                                                                                                                                                    • Crystalloids
                                                                                                                                                                    • Colloid Solutions
                                                                                                                                                                    • رینگر لاکتات
                                                                                                                                                                    • 09Nacl
                                                                                                                                                                    • Postoperative (maintenance)
                                                                                                                                                                    • Slide 41
                                                                                                                                                                    • Preexisting fluid deficits
                                                                                                                                                                    • Maintenance requirements
                                                                                                                                                                    • Surgical fluid losses
                                                                                                                                                                    • Third space loss
                                                                                                                                                                    • Crystalloid solution
                                                                                                                                                                    • Colloids
                                                                                                                                                                    • Complications
                                                                                                                                                                    • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                    • Colloid versus crystalloid solutions
                                                                                                                                                                    • Transfusion consideration
                                                                                                                                                                    • اختلال در حجم مایعات بدن
                                                                                                                                                                    • Fluid volume deficit (FVD)
                                                                                                                                                                    • DEHYDRATION
                                                                                                                                                                    • علل کاهش حجم خارج سلولی
                                                                                                                                                                    • Signs of Hypovolemia
                                                                                                                                                                    • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                    • Signs of Hypervolemia
                                                                                                                                                                    • Management of Hypervolemia
                                                                                                                                                                    • Fluid Management
                                                                                                                                                                    • Electrolyte physiology
                                                                                                                                                                    • Sodium physiology
                                                                                                                                                                    • Osmotic Pressure
                                                                                                                                                                    • Concentration
                                                                                                                                                                    • Hypernatremia
                                                                                                                                                                    • - Hypernatremia
                                                                                                                                                                    • Slide 67
                                                                                                                                                                    • Slide 68
                                                                                                                                                                    • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                    • Treatment
                                                                                                                                                                    • Water deficit (L)= times TBW
                                                                                                                                                                    • The rate of fluid administration
                                                                                                                                                                    • Hyponatremia Nalt135mEqL
                                                                                                                                                                    • Slide 74
                                                                                                                                                                    • Sodium depletion
                                                                                                                                                                    • Sodium dilution
                                                                                                                                                                    • Sign and symptoms
                                                                                                                                                                    • Slide 78
                                                                                                                                                                    • Treatment
                                                                                                                                                                    • Slide 80
                                                                                                                                                                    • Slide 81
                                                                                                                                                                    • Dose
                                                                                                                                                                    • Potassium abnormalities
                                                                                                                                                                    • Hyperkalemia
                                                                                                                                                                    • Clinical manifestation of hyperkalemia
                                                                                                                                                                    • Slide 86
                                                                                                                                                                    • Slide 87
                                                                                                                                                                    • Hypokalemia
                                                                                                                                                                    • Potassium changes associated with alkalosis
                                                                                                                                                                    • Slide 90
                                                                                                                                                                    • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                    • Slide 92
                                                                                                                                                                    • Calcium
                                                                                                                                                                    • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                    • علائم هیپوکلسمی
                                                                                                                                                                    • Slide 96
                                                                                                                                                                    • Slide 97
                                                                                                                                                                    • Slide 98
                                                                                                                                                                    • Slide 99
                                                                                                                                                                    • سایرعلائم
                                                                                                                                                                    • درمان
                                                                                                                                                                    • هيپركلسمي Cagt55meql
                                                                                                                                                                    • علائم
                                                                                                                                                                    • علائم قلبی
                                                                                                                                                                    • Slide 105
                                                                                                                                                                    • Magnesium Abnormalities
                                                                                                                                                                    • منیزیوم
                                                                                                                                                                    • Hypermagnesemia
                                                                                                                                                                    • Clinical manifestation hypermanesemia
                                                                                                                                                                    • Slide 110
                                                                                                                                                                    • Slide 111
                                                                                                                                                                    • Hypomagnesemia
                                                                                                                                                                    • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                    • Slide 114
                                                                                                                                                                    • Message for Today
                                                                                                                                                                    • Slide 116

                                                                                                                                                                      Hyperkalemia

                                                                                                                                                                      The normal range of serum potassium 35-5 meqL

                                                                                                                                                                      Etiology of Hyperkalemia

                                                                                                                                                                      Increased intake Potassium supplementation

                                                                                                                                                                      Blood transfusions

                                                                                                                                                                      Endogenous loaddestruction

                                                                                                                                                                      hemolysis rhabdomyolysis

                                                                                                                                                                      cruch injury gastrointestinal hemorrhage

                                                                                                                                                                      Increased release Acidosis

                                                                                                                                                                      Rapid rise of extracellure osmolality (hyperglycemia or mannitol)Impaired excretion of potassium

                                                                                                                                                                      Renal insufficiencyfailure

                                                                                                                                                                      Clinical manifestation of hyperkalemia

                                                                                                                                                                      System hyperkalemia

                                                                                                                                                                      Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                                                      Neuromuscular weakness paralysis respiratory failure

                                                                                                                                                                      Cardiovascular Arrhythmia arrest

                                                                                                                                                                      ECG changes Peaked T waves (early change)

                                                                                                                                                                      Flattened P wave

                                                                                                                                                                      Prolonged PR interval (first-degree block)

                                                                                                                                                                      Widened QRS complex

                                                                                                                                                                      Sine wave formation

                                                                                                                                                                      Ventricular fibrillation

                                                                                                                                                                      Treatment

                                                                                                                                                                      Treatment of symptomatic hyperkalemia

                                                                                                                                                                      Potassium removal Kayexalate

                                                                                                                                                                      Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                                                      Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                                                      Dialysis

                                                                                                                                                                      Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                                                      Bicarbonate 1 vial intravenous

                                                                                                                                                                      Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                                                      HypokalemiaEtiology

                                                                                                                                                                      inadequate intake

                                                                                                                                                                      Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                                                      total parenteral nutrition

                                                                                                                                                                      Excessive potassium excretion

                                                                                                                                                                      Hyperaldosteronism

                                                                                                                                                                      Medications

                                                                                                                                                                      Gastrointestinal losses

                                                                                                                                                                      Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                                                      Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                                                      nasogastric output)

                                                                                                                                                                      Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                                                      Potassium changes associated with alkalosis

                                                                                                                                                                      Potassium decrease by 03 meqL for every 01

                                                                                                                                                                      increase in PH above normal

                                                                                                                                                                      Magnesium Depletion

                                                                                                                                                                      (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                                      Renal potassium wastage

                                                                                                                                                                      Hypokalemia

                                                                                                                                                                      Magnesium Depletion

                                                                                                                                                                      (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                                      Renal potassium wastage

                                                                                                                                                                      Hypokalemia

                                                                                                                                                                      Clinical Manifestation of Abnormalities in potassium

                                                                                                                                                                      System hypokalemia

                                                                                                                                                                      Gastrointestinal Ileus constipation

                                                                                                                                                                      Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                                                      paralysis

                                                                                                                                                                      Cardiovascular Arrest

                                                                                                                                                                      ECG changes U-waves

                                                                                                                                                                      T-wave flattening

                                                                                                                                                                      ST-segment changes

                                                                                                                                                                      Arrhythmias

                                                                                                                                                                      Treatment

                                                                                                                                                                      Potassium

                                                                                                                                                                      Serum potassium level lt40 mEqL

                                                                                                                                                                      Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                                                      times 1 doses

                                                                                                                                                                      Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                                                      Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                                                      Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                                                      asymptomatic replace as per above protocol

                                                                                                                                                                      Electrolyte Replacement Therapy Protocol

                                                                                                                                                                      bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                                                      bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                                                      Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                                      ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                                      عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                                      صاف 2 عضالت انقباض

                                                                                                                                                                      هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                                      انعقاد 4

                                                                                                                                                                      یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                                      عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                                      ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                                      میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                                      ( شود می پیوند شده

                                                                                                                                                                      هیپوکلسمی عالئم

                                                                                                                                                                      رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                                      سایرعالئم

                                                                                                                                                                      قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                                      درمان

                                                                                                                                                                      ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                                      Cagt55meql هيپركلسمي

                                                                                                                                                                      هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                                      عالئم

                                                                                                                                                                      bullGI

                                                                                                                                                                      bullCardiovascular bullRenal (polyuria)

                                                                                                                                                                      bullCNS

                                                                                                                                                                      قلبی عالئم

                                                                                                                                                                      bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                                      QRS شدن )Q-Tوكوتاه

                                                                                                                                                                      درمان

                                                                                                                                                                      ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                      الزیکس2

                                                                                                                                                                      تونین 3 کلسی

                                                                                                                                                                      کورتون4

                                                                                                                                                                      دیالیز5

                                                                                                                                                                      Magnesium Abnormalities

                                                                                                                                                                      Normal dietary intake 20meq (240mg)

                                                                                                                                                                      Excretion in both the feces and urine

                                                                                                                                                                      Normal serum level 19-25 mgdL

                                                                                                                                                                      منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                      تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                      bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                      Hypermagnesemia

                                                                                                                                                                      Etiology

                                                                                                                                                                      1 Impaired renal function

                                                                                                                                                                      2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                      Clinical manifestation hypermanesemia

                                                                                                                                                                      System hypermanesemia

                                                                                                                                                                      Gastrointestinal Nauseavomiting

                                                                                                                                                                      Neuromuscular weakness lethargy Decreased

                                                                                                                                                                      reflexes

                                                                                                                                                                      Cardiovascular Hypotension arrest

                                                                                                                                                                      ECG changes Increased PR interval

                                                                                                                                                                      Widened QRS complex

                                                                                                                                                                      Elevated T waves

                                                                                                                                                                      Treatment

                                                                                                                                                                      1 Withhold exogenous sources of magnesium

                                                                                                                                                                      2 Correct volume deficit

                                                                                                                                                                      3 Correct acidosis if present

                                                                                                                                                                      4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                      5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                      عالئم

                                                                                                                                                                      bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                      meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                      meqL

                                                                                                                                                                      Hypomagnesemia

                                                                                                                                                                      Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                      homeostasis

                                                                                                                                                                      Etiology

                                                                                                                                                                      1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                      inadequate supplementation of magnesium)

                                                                                                                                                                      2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                      3 GI losses (diarrhea)

                                                                                                                                                                      4 Malabsorption

                                                                                                                                                                      5 Acute pancreatitis

                                                                                                                                                                      6 Diabetic ketoacidosis

                                                                                                                                                                      7 Primary aldosteronism

                                                                                                                                                                      Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                      1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                      2 Delirium and seizures in severe deficiency

                                                                                                                                                                      3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                      ST-segment depression

                                                                                                                                                                      Flattening or inversion of P waves

                                                                                                                                                                      Torsades de pointes

                                                                                                                                                                      Arrhythmia

                                                                                                                                                                      Treatment

                                                                                                                                                                      1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                      2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                      Message for Today

                                                                                                                                                                      ICF

                                                                                                                                                                      Interstitial

                                                                                                                                                                      Pla

                                                                                                                                                                      sma

                                                                                                                                                                      5 Dex

                                                                                                                                                                      bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                      • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                      • Slide 2
                                                                                                                                                                      • Slide 3
                                                                                                                                                                      • Slide 4
                                                                                                                                                                      • Total Body Water
                                                                                                                                                                      • Body Fluid Compartments
                                                                                                                                                                      • Total body water (TBW)
                                                                                                                                                                      • Body compartment fluid
                                                                                                                                                                      • Example men with 70kg
                                                                                                                                                                      • Fluid compartments
                                                                                                                                                                      • Slide 11
                                                                                                                                                                      • Slide 12
                                                                                                                                                                      • Slide 13
                                                                                                                                                                      • Slide 14
                                                                                                                                                                      • Slide 15
                                                                                                                                                                      • Colloid osmotic pressure
                                                                                                                                                                      • Slide 17
                                                                                                                                                                      • Slide 18
                                                                                                                                                                      • Slide 19
                                                                                                                                                                      • Cell Membrane
                                                                                                                                                                      • Slide 21
                                                                                                                                                                      • Slide 22
                                                                                                                                                                      • Slide 23
                                                                                                                                                                      • Slide 24
                                                                                                                                                                      • Slide 25
                                                                                                                                                                      • Composition of Fluid Compartments
                                                                                                                                                                      • Composition of Body Fluids
                                                                                                                                                                      • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                      • Reasons for fluid therapy
                                                                                                                                                                      • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                      • محلولهای وریدی
                                                                                                                                                                      • Fluids
                                                                                                                                                                      • Slide 33
                                                                                                                                                                      • Slide 34
                                                                                                                                                                      • Slide 35
                                                                                                                                                                      • Crystalloids
                                                                                                                                                                      • Colloid Solutions
                                                                                                                                                                      • رینگر لاکتات
                                                                                                                                                                      • 09Nacl
                                                                                                                                                                      • Postoperative (maintenance)
                                                                                                                                                                      • Slide 41
                                                                                                                                                                      • Preexisting fluid deficits
                                                                                                                                                                      • Maintenance requirements
                                                                                                                                                                      • Surgical fluid losses
                                                                                                                                                                      • Third space loss
                                                                                                                                                                      • Crystalloid solution
                                                                                                                                                                      • Colloids
                                                                                                                                                                      • Complications
                                                                                                                                                                      • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                      • Colloid versus crystalloid solutions
                                                                                                                                                                      • Transfusion consideration
                                                                                                                                                                      • اختلال در حجم مایعات بدن
                                                                                                                                                                      • Fluid volume deficit (FVD)
                                                                                                                                                                      • DEHYDRATION
                                                                                                                                                                      • علل کاهش حجم خارج سلولی
                                                                                                                                                                      • Signs of Hypovolemia
                                                                                                                                                                      • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                      • Signs of Hypervolemia
                                                                                                                                                                      • Management of Hypervolemia
                                                                                                                                                                      • Fluid Management
                                                                                                                                                                      • Electrolyte physiology
                                                                                                                                                                      • Sodium physiology
                                                                                                                                                                      • Osmotic Pressure
                                                                                                                                                                      • Concentration
                                                                                                                                                                      • Hypernatremia
                                                                                                                                                                      • - Hypernatremia
                                                                                                                                                                      • Slide 67
                                                                                                                                                                      • Slide 68
                                                                                                                                                                      • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                      • Treatment
                                                                                                                                                                      • Water deficit (L)= times TBW
                                                                                                                                                                      • The rate of fluid administration
                                                                                                                                                                      • Hyponatremia Nalt135mEqL
                                                                                                                                                                      • Slide 74
                                                                                                                                                                      • Sodium depletion
                                                                                                                                                                      • Sodium dilution
                                                                                                                                                                      • Sign and symptoms
                                                                                                                                                                      • Slide 78
                                                                                                                                                                      • Treatment
                                                                                                                                                                      • Slide 80
                                                                                                                                                                      • Slide 81
                                                                                                                                                                      • Dose
                                                                                                                                                                      • Potassium abnormalities
                                                                                                                                                                      • Hyperkalemia
                                                                                                                                                                      • Clinical manifestation of hyperkalemia
                                                                                                                                                                      • Slide 86
                                                                                                                                                                      • Slide 87
                                                                                                                                                                      • Hypokalemia
                                                                                                                                                                      • Potassium changes associated with alkalosis
                                                                                                                                                                      • Slide 90
                                                                                                                                                                      • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                      • Slide 92
                                                                                                                                                                      • Calcium
                                                                                                                                                                      • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                      • علائم هیپوکلسمی
                                                                                                                                                                      • Slide 96
                                                                                                                                                                      • Slide 97
                                                                                                                                                                      • Slide 98
                                                                                                                                                                      • Slide 99
                                                                                                                                                                      • سایرعلائم
                                                                                                                                                                      • درمان
                                                                                                                                                                      • هيپركلسمي Cagt55meql
                                                                                                                                                                      • علائم
                                                                                                                                                                      • علائم قلبی
                                                                                                                                                                      • Slide 105
                                                                                                                                                                      • Magnesium Abnormalities
                                                                                                                                                                      • منیزیوم
                                                                                                                                                                      • Hypermagnesemia
                                                                                                                                                                      • Clinical manifestation hypermanesemia
                                                                                                                                                                      • Slide 110
                                                                                                                                                                      • Slide 111
                                                                                                                                                                      • Hypomagnesemia
                                                                                                                                                                      • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                      • Slide 114
                                                                                                                                                                      • Message for Today
                                                                                                                                                                      • Slide 116

                                                                                                                                                                        Clinical manifestation of hyperkalemia

                                                                                                                                                                        System hyperkalemia

                                                                                                                                                                        Gastrointestinal Nauseavomiting colic diarrhea

                                                                                                                                                                        Neuromuscular weakness paralysis respiratory failure

                                                                                                                                                                        Cardiovascular Arrhythmia arrest

                                                                                                                                                                        ECG changes Peaked T waves (early change)

                                                                                                                                                                        Flattened P wave

                                                                                                                                                                        Prolonged PR interval (first-degree block)

                                                                                                                                                                        Widened QRS complex

                                                                                                                                                                        Sine wave formation

                                                                                                                                                                        Ventricular fibrillation

                                                                                                                                                                        Treatment

                                                                                                                                                                        Treatment of symptomatic hyperkalemia

                                                                                                                                                                        Potassium removal Kayexalate

                                                                                                                                                                        Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                                                        Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                                                        Dialysis

                                                                                                                                                                        Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                                                        Bicarbonate 1 vial intravenous

                                                                                                                                                                        Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                                                        HypokalemiaEtiology

                                                                                                                                                                        inadequate intake

                                                                                                                                                                        Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                                                        total parenteral nutrition

                                                                                                                                                                        Excessive potassium excretion

                                                                                                                                                                        Hyperaldosteronism

                                                                                                                                                                        Medications

                                                                                                                                                                        Gastrointestinal losses

                                                                                                                                                                        Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                                                        Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                                                        nasogastric output)

                                                                                                                                                                        Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                                                        Potassium changes associated with alkalosis

                                                                                                                                                                        Potassium decrease by 03 meqL for every 01

                                                                                                                                                                        increase in PH above normal

                                                                                                                                                                        Magnesium Depletion

                                                                                                                                                                        (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                                        Renal potassium wastage

                                                                                                                                                                        Hypokalemia

                                                                                                                                                                        Magnesium Depletion

                                                                                                                                                                        (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                                        Renal potassium wastage

                                                                                                                                                                        Hypokalemia

                                                                                                                                                                        Clinical Manifestation of Abnormalities in potassium

                                                                                                                                                                        System hypokalemia

                                                                                                                                                                        Gastrointestinal Ileus constipation

                                                                                                                                                                        Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                                                        paralysis

                                                                                                                                                                        Cardiovascular Arrest

                                                                                                                                                                        ECG changes U-waves

                                                                                                                                                                        T-wave flattening

                                                                                                                                                                        ST-segment changes

                                                                                                                                                                        Arrhythmias

                                                                                                                                                                        Treatment

                                                                                                                                                                        Potassium

                                                                                                                                                                        Serum potassium level lt40 mEqL

                                                                                                                                                                        Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                                                        times 1 doses

                                                                                                                                                                        Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                                                        Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                                                        Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                                                        asymptomatic replace as per above protocol

                                                                                                                                                                        Electrolyte Replacement Therapy Protocol

                                                                                                                                                                        bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                                                        bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                                                        Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                                        ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                                        عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                                        صاف 2 عضالت انقباض

                                                                                                                                                                        هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                                        انعقاد 4

                                                                                                                                                                        یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                                        عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                                        ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                                        میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                                        ( شود می پیوند شده

                                                                                                                                                                        هیپوکلسمی عالئم

                                                                                                                                                                        رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                                        سایرعالئم

                                                                                                                                                                        قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                                        درمان

                                                                                                                                                                        ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                                        Cagt55meql هيپركلسمي

                                                                                                                                                                        هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                                        عالئم

                                                                                                                                                                        bullGI

                                                                                                                                                                        bullCardiovascular bullRenal (polyuria)

                                                                                                                                                                        bullCNS

                                                                                                                                                                        قلبی عالئم

                                                                                                                                                                        bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                                        QRS شدن )Q-Tوكوتاه

                                                                                                                                                                        درمان

                                                                                                                                                                        ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                        الزیکس2

                                                                                                                                                                        تونین 3 کلسی

                                                                                                                                                                        کورتون4

                                                                                                                                                                        دیالیز5

                                                                                                                                                                        Magnesium Abnormalities

                                                                                                                                                                        Normal dietary intake 20meq (240mg)

                                                                                                                                                                        Excretion in both the feces and urine

                                                                                                                                                                        Normal serum level 19-25 mgdL

                                                                                                                                                                        منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                        تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                        bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                        Hypermagnesemia

                                                                                                                                                                        Etiology

                                                                                                                                                                        1 Impaired renal function

                                                                                                                                                                        2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                        Clinical manifestation hypermanesemia

                                                                                                                                                                        System hypermanesemia

                                                                                                                                                                        Gastrointestinal Nauseavomiting

                                                                                                                                                                        Neuromuscular weakness lethargy Decreased

                                                                                                                                                                        reflexes

                                                                                                                                                                        Cardiovascular Hypotension arrest

                                                                                                                                                                        ECG changes Increased PR interval

                                                                                                                                                                        Widened QRS complex

                                                                                                                                                                        Elevated T waves

                                                                                                                                                                        Treatment

                                                                                                                                                                        1 Withhold exogenous sources of magnesium

                                                                                                                                                                        2 Correct volume deficit

                                                                                                                                                                        3 Correct acidosis if present

                                                                                                                                                                        4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                        5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                        عالئم

                                                                                                                                                                        bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                        meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                        meqL

                                                                                                                                                                        Hypomagnesemia

                                                                                                                                                                        Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                        homeostasis

                                                                                                                                                                        Etiology

                                                                                                                                                                        1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                        inadequate supplementation of magnesium)

                                                                                                                                                                        2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                        3 GI losses (diarrhea)

                                                                                                                                                                        4 Malabsorption

                                                                                                                                                                        5 Acute pancreatitis

                                                                                                                                                                        6 Diabetic ketoacidosis

                                                                                                                                                                        7 Primary aldosteronism

                                                                                                                                                                        Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                        1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                        2 Delirium and seizures in severe deficiency

                                                                                                                                                                        3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                        ST-segment depression

                                                                                                                                                                        Flattening or inversion of P waves

                                                                                                                                                                        Torsades de pointes

                                                                                                                                                                        Arrhythmia

                                                                                                                                                                        Treatment

                                                                                                                                                                        1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                        2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                        Message for Today

                                                                                                                                                                        ICF

                                                                                                                                                                        Interstitial

                                                                                                                                                                        Pla

                                                                                                                                                                        sma

                                                                                                                                                                        5 Dex

                                                                                                                                                                        bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                        • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                        • Slide 2
                                                                                                                                                                        • Slide 3
                                                                                                                                                                        • Slide 4
                                                                                                                                                                        • Total Body Water
                                                                                                                                                                        • Body Fluid Compartments
                                                                                                                                                                        • Total body water (TBW)
                                                                                                                                                                        • Body compartment fluid
                                                                                                                                                                        • Example men with 70kg
                                                                                                                                                                        • Fluid compartments
                                                                                                                                                                        • Slide 11
                                                                                                                                                                        • Slide 12
                                                                                                                                                                        • Slide 13
                                                                                                                                                                        • Slide 14
                                                                                                                                                                        • Slide 15
                                                                                                                                                                        • Colloid osmotic pressure
                                                                                                                                                                        • Slide 17
                                                                                                                                                                        • Slide 18
                                                                                                                                                                        • Slide 19
                                                                                                                                                                        • Cell Membrane
                                                                                                                                                                        • Slide 21
                                                                                                                                                                        • Slide 22
                                                                                                                                                                        • Slide 23
                                                                                                                                                                        • Slide 24
                                                                                                                                                                        • Slide 25
                                                                                                                                                                        • Composition of Fluid Compartments
                                                                                                                                                                        • Composition of Body Fluids
                                                                                                                                                                        • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                        • Reasons for fluid therapy
                                                                                                                                                                        • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                        • محلولهای وریدی
                                                                                                                                                                        • Fluids
                                                                                                                                                                        • Slide 33
                                                                                                                                                                        • Slide 34
                                                                                                                                                                        • Slide 35
                                                                                                                                                                        • Crystalloids
                                                                                                                                                                        • Colloid Solutions
                                                                                                                                                                        • رینگر لاکتات
                                                                                                                                                                        • 09Nacl
                                                                                                                                                                        • Postoperative (maintenance)
                                                                                                                                                                        • Slide 41
                                                                                                                                                                        • Preexisting fluid deficits
                                                                                                                                                                        • Maintenance requirements
                                                                                                                                                                        • Surgical fluid losses
                                                                                                                                                                        • Third space loss
                                                                                                                                                                        • Crystalloid solution
                                                                                                                                                                        • Colloids
                                                                                                                                                                        • Complications
                                                                                                                                                                        • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                        • Colloid versus crystalloid solutions
                                                                                                                                                                        • Transfusion consideration
                                                                                                                                                                        • اختلال در حجم مایعات بدن
                                                                                                                                                                        • Fluid volume deficit (FVD)
                                                                                                                                                                        • DEHYDRATION
                                                                                                                                                                        • علل کاهش حجم خارج سلولی
                                                                                                                                                                        • Signs of Hypovolemia
                                                                                                                                                                        • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                        • Signs of Hypervolemia
                                                                                                                                                                        • Management of Hypervolemia
                                                                                                                                                                        • Fluid Management
                                                                                                                                                                        • Electrolyte physiology
                                                                                                                                                                        • Sodium physiology
                                                                                                                                                                        • Osmotic Pressure
                                                                                                                                                                        • Concentration
                                                                                                                                                                        • Hypernatremia
                                                                                                                                                                        • - Hypernatremia
                                                                                                                                                                        • Slide 67
                                                                                                                                                                        • Slide 68
                                                                                                                                                                        • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                        • Treatment
                                                                                                                                                                        • Water deficit (L)= times TBW
                                                                                                                                                                        • The rate of fluid administration
                                                                                                                                                                        • Hyponatremia Nalt135mEqL
                                                                                                                                                                        • Slide 74
                                                                                                                                                                        • Sodium depletion
                                                                                                                                                                        • Sodium dilution
                                                                                                                                                                        • Sign and symptoms
                                                                                                                                                                        • Slide 78
                                                                                                                                                                        • Treatment
                                                                                                                                                                        • Slide 80
                                                                                                                                                                        • Slide 81
                                                                                                                                                                        • Dose
                                                                                                                                                                        • Potassium abnormalities
                                                                                                                                                                        • Hyperkalemia
                                                                                                                                                                        • Clinical manifestation of hyperkalemia
                                                                                                                                                                        • Slide 86
                                                                                                                                                                        • Slide 87
                                                                                                                                                                        • Hypokalemia
                                                                                                                                                                        • Potassium changes associated with alkalosis
                                                                                                                                                                        • Slide 90
                                                                                                                                                                        • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                        • Slide 92
                                                                                                                                                                        • Calcium
                                                                                                                                                                        • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                        • علائم هیپوکلسمی
                                                                                                                                                                        • Slide 96
                                                                                                                                                                        • Slide 97
                                                                                                                                                                        • Slide 98
                                                                                                                                                                        • Slide 99
                                                                                                                                                                        • سایرعلائم
                                                                                                                                                                        • درمان
                                                                                                                                                                        • هيپركلسمي Cagt55meql
                                                                                                                                                                        • علائم
                                                                                                                                                                        • علائم قلبی
                                                                                                                                                                        • Slide 105
                                                                                                                                                                        • Magnesium Abnormalities
                                                                                                                                                                        • منیزیوم
                                                                                                                                                                        • Hypermagnesemia
                                                                                                                                                                        • Clinical manifestation hypermanesemia
                                                                                                                                                                        • Slide 110
                                                                                                                                                                        • Slide 111
                                                                                                                                                                        • Hypomagnesemia
                                                                                                                                                                        • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                        • Slide 114
                                                                                                                                                                        • Message for Today
                                                                                                                                                                        • Slide 116

                                                                                                                                                                          Treatment

                                                                                                                                                                          Treatment of symptomatic hyperkalemia

                                                                                                                                                                          Potassium removal Kayexalate

                                                                                                                                                                          Oral administration is 15-30 g in 50-100 mLof 20 sorbitol

                                                                                                                                                                          Rectal administration is 50 g in 200 mL 20 sorbitol

                                                                                                                                                                          Dialysis

                                                                                                                                                                          Shift potassium Glucose 1 vial of D50 and regular insulin 5-10 units intravenous

                                                                                                                                                                          Bicarbonate 1 vial intravenous

                                                                                                                                                                          Counteract cardiac effects Calcium gluconate 5-10 mL of 10 solution

                                                                                                                                                                          HypokalemiaEtiology

                                                                                                                                                                          inadequate intake

                                                                                                                                                                          Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                                                          total parenteral nutrition

                                                                                                                                                                          Excessive potassium excretion

                                                                                                                                                                          Hyperaldosteronism

                                                                                                                                                                          Medications

                                                                                                                                                                          Gastrointestinal losses

                                                                                                                                                                          Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                                                          Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                                                          nasogastric output)

                                                                                                                                                                          Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                                                          Potassium changes associated with alkalosis

                                                                                                                                                                          Potassium decrease by 03 meqL for every 01

                                                                                                                                                                          increase in PH above normal

                                                                                                                                                                          Magnesium Depletion

                                                                                                                                                                          (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                                          Renal potassium wastage

                                                                                                                                                                          Hypokalemia

                                                                                                                                                                          Magnesium Depletion

                                                                                                                                                                          (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                                          Renal potassium wastage

                                                                                                                                                                          Hypokalemia

                                                                                                                                                                          Clinical Manifestation of Abnormalities in potassium

                                                                                                                                                                          System hypokalemia

                                                                                                                                                                          Gastrointestinal Ileus constipation

                                                                                                                                                                          Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                                                          paralysis

                                                                                                                                                                          Cardiovascular Arrest

                                                                                                                                                                          ECG changes U-waves

                                                                                                                                                                          T-wave flattening

                                                                                                                                                                          ST-segment changes

                                                                                                                                                                          Arrhythmias

                                                                                                                                                                          Treatment

                                                                                                                                                                          Potassium

                                                                                                                                                                          Serum potassium level lt40 mEqL

                                                                                                                                                                          Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                                                          times 1 doses

                                                                                                                                                                          Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                                                          Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                                                          Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                                                          asymptomatic replace as per above protocol

                                                                                                                                                                          Electrolyte Replacement Therapy Protocol

                                                                                                                                                                          bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                                                          bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                                                          Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                                          ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                                          عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                                          صاف 2 عضالت انقباض

                                                                                                                                                                          هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                                          انعقاد 4

                                                                                                                                                                          یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                                          عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                                          ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                                          میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                                          ( شود می پیوند شده

                                                                                                                                                                          هیپوکلسمی عالئم

                                                                                                                                                                          رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                                          سایرعالئم

                                                                                                                                                                          قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                                          درمان

                                                                                                                                                                          ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                                          Cagt55meql هيپركلسمي

                                                                                                                                                                          هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                                          عالئم

                                                                                                                                                                          bullGI

                                                                                                                                                                          bullCardiovascular bullRenal (polyuria)

                                                                                                                                                                          bullCNS

                                                                                                                                                                          قلبی عالئم

                                                                                                                                                                          bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                                          QRS شدن )Q-Tوكوتاه

                                                                                                                                                                          درمان

                                                                                                                                                                          ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                          الزیکس2

                                                                                                                                                                          تونین 3 کلسی

                                                                                                                                                                          کورتون4

                                                                                                                                                                          دیالیز5

                                                                                                                                                                          Magnesium Abnormalities

                                                                                                                                                                          Normal dietary intake 20meq (240mg)

                                                                                                                                                                          Excretion in both the feces and urine

                                                                                                                                                                          Normal serum level 19-25 mgdL

                                                                                                                                                                          منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                          تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                          bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                          Hypermagnesemia

                                                                                                                                                                          Etiology

                                                                                                                                                                          1 Impaired renal function

                                                                                                                                                                          2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                          Clinical manifestation hypermanesemia

                                                                                                                                                                          System hypermanesemia

                                                                                                                                                                          Gastrointestinal Nauseavomiting

                                                                                                                                                                          Neuromuscular weakness lethargy Decreased

                                                                                                                                                                          reflexes

                                                                                                                                                                          Cardiovascular Hypotension arrest

                                                                                                                                                                          ECG changes Increased PR interval

                                                                                                                                                                          Widened QRS complex

                                                                                                                                                                          Elevated T waves

                                                                                                                                                                          Treatment

                                                                                                                                                                          1 Withhold exogenous sources of magnesium

                                                                                                                                                                          2 Correct volume deficit

                                                                                                                                                                          3 Correct acidosis if present

                                                                                                                                                                          4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                          5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                          عالئم

                                                                                                                                                                          bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                          meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                          meqL

                                                                                                                                                                          Hypomagnesemia

                                                                                                                                                                          Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                          homeostasis

                                                                                                                                                                          Etiology

                                                                                                                                                                          1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                          inadequate supplementation of magnesium)

                                                                                                                                                                          2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                          3 GI losses (diarrhea)

                                                                                                                                                                          4 Malabsorption

                                                                                                                                                                          5 Acute pancreatitis

                                                                                                                                                                          6 Diabetic ketoacidosis

                                                                                                                                                                          7 Primary aldosteronism

                                                                                                                                                                          Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                          1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                          2 Delirium and seizures in severe deficiency

                                                                                                                                                                          3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                          ST-segment depression

                                                                                                                                                                          Flattening or inversion of P waves

                                                                                                                                                                          Torsades de pointes

                                                                                                                                                                          Arrhythmia

                                                                                                                                                                          Treatment

                                                                                                                                                                          1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                          2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                          Message for Today

                                                                                                                                                                          ICF

                                                                                                                                                                          Interstitial

                                                                                                                                                                          Pla

                                                                                                                                                                          sma

                                                                                                                                                                          5 Dex

                                                                                                                                                                          bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                          • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                          • Slide 2
                                                                                                                                                                          • Slide 3
                                                                                                                                                                          • Slide 4
                                                                                                                                                                          • Total Body Water
                                                                                                                                                                          • Body Fluid Compartments
                                                                                                                                                                          • Total body water (TBW)
                                                                                                                                                                          • Body compartment fluid
                                                                                                                                                                          • Example men with 70kg
                                                                                                                                                                          • Fluid compartments
                                                                                                                                                                          • Slide 11
                                                                                                                                                                          • Slide 12
                                                                                                                                                                          • Slide 13
                                                                                                                                                                          • Slide 14
                                                                                                                                                                          • Slide 15
                                                                                                                                                                          • Colloid osmotic pressure
                                                                                                                                                                          • Slide 17
                                                                                                                                                                          • Slide 18
                                                                                                                                                                          • Slide 19
                                                                                                                                                                          • Cell Membrane
                                                                                                                                                                          • Slide 21
                                                                                                                                                                          • Slide 22
                                                                                                                                                                          • Slide 23
                                                                                                                                                                          • Slide 24
                                                                                                                                                                          • Slide 25
                                                                                                                                                                          • Composition of Fluid Compartments
                                                                                                                                                                          • Composition of Body Fluids
                                                                                                                                                                          • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                          • Reasons for fluid therapy
                                                                                                                                                                          • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                          • محلولهای وریدی
                                                                                                                                                                          • Fluids
                                                                                                                                                                          • Slide 33
                                                                                                                                                                          • Slide 34
                                                                                                                                                                          • Slide 35
                                                                                                                                                                          • Crystalloids
                                                                                                                                                                          • Colloid Solutions
                                                                                                                                                                          • رینگر لاکتات
                                                                                                                                                                          • 09Nacl
                                                                                                                                                                          • Postoperative (maintenance)
                                                                                                                                                                          • Slide 41
                                                                                                                                                                          • Preexisting fluid deficits
                                                                                                                                                                          • Maintenance requirements
                                                                                                                                                                          • Surgical fluid losses
                                                                                                                                                                          • Third space loss
                                                                                                                                                                          • Crystalloid solution
                                                                                                                                                                          • Colloids
                                                                                                                                                                          • Complications
                                                                                                                                                                          • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                          • Colloid versus crystalloid solutions
                                                                                                                                                                          • Transfusion consideration
                                                                                                                                                                          • اختلال در حجم مایعات بدن
                                                                                                                                                                          • Fluid volume deficit (FVD)
                                                                                                                                                                          • DEHYDRATION
                                                                                                                                                                          • علل کاهش حجم خارج سلولی
                                                                                                                                                                          • Signs of Hypovolemia
                                                                                                                                                                          • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                          • Signs of Hypervolemia
                                                                                                                                                                          • Management of Hypervolemia
                                                                                                                                                                          • Fluid Management
                                                                                                                                                                          • Electrolyte physiology
                                                                                                                                                                          • Sodium physiology
                                                                                                                                                                          • Osmotic Pressure
                                                                                                                                                                          • Concentration
                                                                                                                                                                          • Hypernatremia
                                                                                                                                                                          • - Hypernatremia
                                                                                                                                                                          • Slide 67
                                                                                                                                                                          • Slide 68
                                                                                                                                                                          • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                          • Treatment
                                                                                                                                                                          • Water deficit (L)= times TBW
                                                                                                                                                                          • The rate of fluid administration
                                                                                                                                                                          • Hyponatremia Nalt135mEqL
                                                                                                                                                                          • Slide 74
                                                                                                                                                                          • Sodium depletion
                                                                                                                                                                          • Sodium dilution
                                                                                                                                                                          • Sign and symptoms
                                                                                                                                                                          • Slide 78
                                                                                                                                                                          • Treatment
                                                                                                                                                                          • Slide 80
                                                                                                                                                                          • Slide 81
                                                                                                                                                                          • Dose
                                                                                                                                                                          • Potassium abnormalities
                                                                                                                                                                          • Hyperkalemia
                                                                                                                                                                          • Clinical manifestation of hyperkalemia
                                                                                                                                                                          • Slide 86
                                                                                                                                                                          • Slide 87
                                                                                                                                                                          • Hypokalemia
                                                                                                                                                                          • Potassium changes associated with alkalosis
                                                                                                                                                                          • Slide 90
                                                                                                                                                                          • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                          • Slide 92
                                                                                                                                                                          • Calcium
                                                                                                                                                                          • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                          • علائم هیپوکلسمی
                                                                                                                                                                          • Slide 96
                                                                                                                                                                          • Slide 97
                                                                                                                                                                          • Slide 98
                                                                                                                                                                          • Slide 99
                                                                                                                                                                          • سایرعلائم
                                                                                                                                                                          • درمان
                                                                                                                                                                          • هيپركلسمي Cagt55meql
                                                                                                                                                                          • علائم
                                                                                                                                                                          • علائم قلبی
                                                                                                                                                                          • Slide 105
                                                                                                                                                                          • Magnesium Abnormalities
                                                                                                                                                                          • منیزیوم
                                                                                                                                                                          • Hypermagnesemia
                                                                                                                                                                          • Clinical manifestation hypermanesemia
                                                                                                                                                                          • Slide 110
                                                                                                                                                                          • Slide 111
                                                                                                                                                                          • Hypomagnesemia
                                                                                                                                                                          • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                          • Slide 114
                                                                                                                                                                          • Message for Today
                                                                                                                                                                          • Slide 116

                                                                                                                                                                            HypokalemiaEtiology

                                                                                                                                                                            inadequate intake

                                                                                                                                                                            Dietary potassium-free intravenous fluids potassium-deficient

                                                                                                                                                                            total parenteral nutrition

                                                                                                                                                                            Excessive potassium excretion

                                                                                                                                                                            Hyperaldosteronism

                                                                                                                                                                            Medications

                                                                                                                                                                            Gastrointestinal losses

                                                                                                                                                                            Direct loss of potassium from gastrointestinal fluid (diarrhea)

                                                                                                                                                                            Renal loss of potassium (gastric fluid either as vomiting or high

                                                                                                                                                                            nasogastric output)

                                                                                                                                                                            Intracellular-shift (metabolic alkalosis or insulin therapy)

                                                                                                                                                                            Potassium changes associated with alkalosis

                                                                                                                                                                            Potassium decrease by 03 meqL for every 01

                                                                                                                                                                            increase in PH above normal

                                                                                                                                                                            Magnesium Depletion

                                                                                                                                                                            (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                                            Renal potassium wastage

                                                                                                                                                                            Hypokalemia

                                                                                                                                                                            Magnesium Depletion

                                                                                                                                                                            (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                                            Renal potassium wastage

                                                                                                                                                                            Hypokalemia

                                                                                                                                                                            Clinical Manifestation of Abnormalities in potassium

                                                                                                                                                                            System hypokalemia

                                                                                                                                                                            Gastrointestinal Ileus constipation

                                                                                                                                                                            Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                                                            paralysis

                                                                                                                                                                            Cardiovascular Arrest

                                                                                                                                                                            ECG changes U-waves

                                                                                                                                                                            T-wave flattening

                                                                                                                                                                            ST-segment changes

                                                                                                                                                                            Arrhythmias

                                                                                                                                                                            Treatment

                                                                                                                                                                            Potassium

                                                                                                                                                                            Serum potassium level lt40 mEqL

                                                                                                                                                                            Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                                                            times 1 doses

                                                                                                                                                                            Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                                                            Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                                                            Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                                                            asymptomatic replace as per above protocol

                                                                                                                                                                            Electrolyte Replacement Therapy Protocol

                                                                                                                                                                            bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                                                            bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                                                            Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                                            ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                                            عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                                            صاف 2 عضالت انقباض

                                                                                                                                                                            هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                                            انعقاد 4

                                                                                                                                                                            یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                                            عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                                            ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                                            میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                                            ( شود می پیوند شده

                                                                                                                                                                            هیپوکلسمی عالئم

                                                                                                                                                                            رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                                            سایرعالئم

                                                                                                                                                                            قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                                            درمان

                                                                                                                                                                            ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                                            Cagt55meql هيپركلسمي

                                                                                                                                                                            هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                                            عالئم

                                                                                                                                                                            bullGI

                                                                                                                                                                            bullCardiovascular bullRenal (polyuria)

                                                                                                                                                                            bullCNS

                                                                                                                                                                            قلبی عالئم

                                                                                                                                                                            bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                                            QRS شدن )Q-Tوكوتاه

                                                                                                                                                                            درمان

                                                                                                                                                                            ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                            الزیکس2

                                                                                                                                                                            تونین 3 کلسی

                                                                                                                                                                            کورتون4

                                                                                                                                                                            دیالیز5

                                                                                                                                                                            Magnesium Abnormalities

                                                                                                                                                                            Normal dietary intake 20meq (240mg)

                                                                                                                                                                            Excretion in both the feces and urine

                                                                                                                                                                            Normal serum level 19-25 mgdL

                                                                                                                                                                            منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                            تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                            bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                            Hypermagnesemia

                                                                                                                                                                            Etiology

                                                                                                                                                                            1 Impaired renal function

                                                                                                                                                                            2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                            Clinical manifestation hypermanesemia

                                                                                                                                                                            System hypermanesemia

                                                                                                                                                                            Gastrointestinal Nauseavomiting

                                                                                                                                                                            Neuromuscular weakness lethargy Decreased

                                                                                                                                                                            reflexes

                                                                                                                                                                            Cardiovascular Hypotension arrest

                                                                                                                                                                            ECG changes Increased PR interval

                                                                                                                                                                            Widened QRS complex

                                                                                                                                                                            Elevated T waves

                                                                                                                                                                            Treatment

                                                                                                                                                                            1 Withhold exogenous sources of magnesium

                                                                                                                                                                            2 Correct volume deficit

                                                                                                                                                                            3 Correct acidosis if present

                                                                                                                                                                            4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                            5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                            عالئم

                                                                                                                                                                            bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                            meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                            meqL

                                                                                                                                                                            Hypomagnesemia

                                                                                                                                                                            Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                            homeostasis

                                                                                                                                                                            Etiology

                                                                                                                                                                            1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                            inadequate supplementation of magnesium)

                                                                                                                                                                            2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                            3 GI losses (diarrhea)

                                                                                                                                                                            4 Malabsorption

                                                                                                                                                                            5 Acute pancreatitis

                                                                                                                                                                            6 Diabetic ketoacidosis

                                                                                                                                                                            7 Primary aldosteronism

                                                                                                                                                                            Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                            1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                            2 Delirium and seizures in severe deficiency

                                                                                                                                                                            3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                            ST-segment depression

                                                                                                                                                                            Flattening or inversion of P waves

                                                                                                                                                                            Torsades de pointes

                                                                                                                                                                            Arrhythmia

                                                                                                                                                                            Treatment

                                                                                                                                                                            1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                            2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                            Message for Today

                                                                                                                                                                            ICF

                                                                                                                                                                            Interstitial

                                                                                                                                                                            Pla

                                                                                                                                                                            sma

                                                                                                                                                                            5 Dex

                                                                                                                                                                            bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                            • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                            • Slide 2
                                                                                                                                                                            • Slide 3
                                                                                                                                                                            • Slide 4
                                                                                                                                                                            • Total Body Water
                                                                                                                                                                            • Body Fluid Compartments
                                                                                                                                                                            • Total body water (TBW)
                                                                                                                                                                            • Body compartment fluid
                                                                                                                                                                            • Example men with 70kg
                                                                                                                                                                            • Fluid compartments
                                                                                                                                                                            • Slide 11
                                                                                                                                                                            • Slide 12
                                                                                                                                                                            • Slide 13
                                                                                                                                                                            • Slide 14
                                                                                                                                                                            • Slide 15
                                                                                                                                                                            • Colloid osmotic pressure
                                                                                                                                                                            • Slide 17
                                                                                                                                                                            • Slide 18
                                                                                                                                                                            • Slide 19
                                                                                                                                                                            • Cell Membrane
                                                                                                                                                                            • Slide 21
                                                                                                                                                                            • Slide 22
                                                                                                                                                                            • Slide 23
                                                                                                                                                                            • Slide 24
                                                                                                                                                                            • Slide 25
                                                                                                                                                                            • Composition of Fluid Compartments
                                                                                                                                                                            • Composition of Body Fluids
                                                                                                                                                                            • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                            • Reasons for fluid therapy
                                                                                                                                                                            • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                            • محلولهای وریدی
                                                                                                                                                                            • Fluids
                                                                                                                                                                            • Slide 33
                                                                                                                                                                            • Slide 34
                                                                                                                                                                            • Slide 35
                                                                                                                                                                            • Crystalloids
                                                                                                                                                                            • Colloid Solutions
                                                                                                                                                                            • رینگر لاکتات
                                                                                                                                                                            • 09Nacl
                                                                                                                                                                            • Postoperative (maintenance)
                                                                                                                                                                            • Slide 41
                                                                                                                                                                            • Preexisting fluid deficits
                                                                                                                                                                            • Maintenance requirements
                                                                                                                                                                            • Surgical fluid losses
                                                                                                                                                                            • Third space loss
                                                                                                                                                                            • Crystalloid solution
                                                                                                                                                                            • Colloids
                                                                                                                                                                            • Complications
                                                                                                                                                                            • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                            • Colloid versus crystalloid solutions
                                                                                                                                                                            • Transfusion consideration
                                                                                                                                                                            • اختلال در حجم مایعات بدن
                                                                                                                                                                            • Fluid volume deficit (FVD)
                                                                                                                                                                            • DEHYDRATION
                                                                                                                                                                            • علل کاهش حجم خارج سلولی
                                                                                                                                                                            • Signs of Hypovolemia
                                                                                                                                                                            • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                            • Signs of Hypervolemia
                                                                                                                                                                            • Management of Hypervolemia
                                                                                                                                                                            • Fluid Management
                                                                                                                                                                            • Electrolyte physiology
                                                                                                                                                                            • Sodium physiology
                                                                                                                                                                            • Osmotic Pressure
                                                                                                                                                                            • Concentration
                                                                                                                                                                            • Hypernatremia
                                                                                                                                                                            • - Hypernatremia
                                                                                                                                                                            • Slide 67
                                                                                                                                                                            • Slide 68
                                                                                                                                                                            • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                            • Treatment
                                                                                                                                                                            • Water deficit (L)= times TBW
                                                                                                                                                                            • The rate of fluid administration
                                                                                                                                                                            • Hyponatremia Nalt135mEqL
                                                                                                                                                                            • Slide 74
                                                                                                                                                                            • Sodium depletion
                                                                                                                                                                            • Sodium dilution
                                                                                                                                                                            • Sign and symptoms
                                                                                                                                                                            • Slide 78
                                                                                                                                                                            • Treatment
                                                                                                                                                                            • Slide 80
                                                                                                                                                                            • Slide 81
                                                                                                                                                                            • Dose
                                                                                                                                                                            • Potassium abnormalities
                                                                                                                                                                            • Hyperkalemia
                                                                                                                                                                            • Clinical manifestation of hyperkalemia
                                                                                                                                                                            • Slide 86
                                                                                                                                                                            • Slide 87
                                                                                                                                                                            • Hypokalemia
                                                                                                                                                                            • Potassium changes associated with alkalosis
                                                                                                                                                                            • Slide 90
                                                                                                                                                                            • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                            • Slide 92
                                                                                                                                                                            • Calcium
                                                                                                                                                                            • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                            • علائم هیپوکلسمی
                                                                                                                                                                            • Slide 96
                                                                                                                                                                            • Slide 97
                                                                                                                                                                            • Slide 98
                                                                                                                                                                            • Slide 99
                                                                                                                                                                            • سایرعلائم
                                                                                                                                                                            • درمان
                                                                                                                                                                            • هيپركلسمي Cagt55meql
                                                                                                                                                                            • علائم
                                                                                                                                                                            • علائم قلبی
                                                                                                                                                                            • Slide 105
                                                                                                                                                                            • Magnesium Abnormalities
                                                                                                                                                                            • منیزیوم
                                                                                                                                                                            • Hypermagnesemia
                                                                                                                                                                            • Clinical manifestation hypermanesemia
                                                                                                                                                                            • Slide 110
                                                                                                                                                                            • Slide 111
                                                                                                                                                                            • Hypomagnesemia
                                                                                                                                                                            • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                            • Slide 114
                                                                                                                                                                            • Message for Today
                                                                                                                                                                            • Slide 116

                                                                                                                                                                              Potassium changes associated with alkalosis

                                                                                                                                                                              Potassium decrease by 03 meqL for every 01

                                                                                                                                                                              increase in PH above normal

                                                                                                                                                                              Magnesium Depletion

                                                                                                                                                                              (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                                              Renal potassium wastage

                                                                                                                                                                              Hypokalemia

                                                                                                                                                                              Magnesium Depletion

                                                                                                                                                                              (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                                              Renal potassium wastage

                                                                                                                                                                              Hypokalemia

                                                                                                                                                                              Clinical Manifestation of Abnormalities in potassium

                                                                                                                                                                              System hypokalemia

                                                                                                                                                                              Gastrointestinal Ileus constipation

                                                                                                                                                                              Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                                                              paralysis

                                                                                                                                                                              Cardiovascular Arrest

                                                                                                                                                                              ECG changes U-waves

                                                                                                                                                                              T-wave flattening

                                                                                                                                                                              ST-segment changes

                                                                                                                                                                              Arrhythmias

                                                                                                                                                                              Treatment

                                                                                                                                                                              Potassium

                                                                                                                                                                              Serum potassium level lt40 mEqL

                                                                                                                                                                              Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                                                              times 1 doses

                                                                                                                                                                              Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                                                              Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                                                              Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                                                              asymptomatic replace as per above protocol

                                                                                                                                                                              Electrolyte Replacement Therapy Protocol

                                                                                                                                                                              bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                                                              bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                                                              Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                                              ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                                              عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                                              صاف 2 عضالت انقباض

                                                                                                                                                                              هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                                              انعقاد 4

                                                                                                                                                                              یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                                              عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                                              ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                                              میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                                              ( شود می پیوند شده

                                                                                                                                                                              هیپوکلسمی عالئم

                                                                                                                                                                              رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                                              سایرعالئم

                                                                                                                                                                              قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                                              درمان

                                                                                                                                                                              ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                                              Cagt55meql هيپركلسمي

                                                                                                                                                                              هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                                              عالئم

                                                                                                                                                                              bullGI

                                                                                                                                                                              bullCardiovascular bullRenal (polyuria)

                                                                                                                                                                              bullCNS

                                                                                                                                                                              قلبی عالئم

                                                                                                                                                                              bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                                              QRS شدن )Q-Tوكوتاه

                                                                                                                                                                              درمان

                                                                                                                                                                              ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                              الزیکس2

                                                                                                                                                                              تونین 3 کلسی

                                                                                                                                                                              کورتون4

                                                                                                                                                                              دیالیز5

                                                                                                                                                                              Magnesium Abnormalities

                                                                                                                                                                              Normal dietary intake 20meq (240mg)

                                                                                                                                                                              Excretion in both the feces and urine

                                                                                                                                                                              Normal serum level 19-25 mgdL

                                                                                                                                                                              منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                              تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                              bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                              Hypermagnesemia

                                                                                                                                                                              Etiology

                                                                                                                                                                              1 Impaired renal function

                                                                                                                                                                              2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                              Clinical manifestation hypermanesemia

                                                                                                                                                                              System hypermanesemia

                                                                                                                                                                              Gastrointestinal Nauseavomiting

                                                                                                                                                                              Neuromuscular weakness lethargy Decreased

                                                                                                                                                                              reflexes

                                                                                                                                                                              Cardiovascular Hypotension arrest

                                                                                                                                                                              ECG changes Increased PR interval

                                                                                                                                                                              Widened QRS complex

                                                                                                                                                                              Elevated T waves

                                                                                                                                                                              Treatment

                                                                                                                                                                              1 Withhold exogenous sources of magnesium

                                                                                                                                                                              2 Correct volume deficit

                                                                                                                                                                              3 Correct acidosis if present

                                                                                                                                                                              4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                              5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                              عالئم

                                                                                                                                                                              bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                              meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                              meqL

                                                                                                                                                                              Hypomagnesemia

                                                                                                                                                                              Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                              homeostasis

                                                                                                                                                                              Etiology

                                                                                                                                                                              1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                              inadequate supplementation of magnesium)

                                                                                                                                                                              2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                              3 GI losses (diarrhea)

                                                                                                                                                                              4 Malabsorption

                                                                                                                                                                              5 Acute pancreatitis

                                                                                                                                                                              6 Diabetic ketoacidosis

                                                                                                                                                                              7 Primary aldosteronism

                                                                                                                                                                              Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                              1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                              2 Delirium and seizures in severe deficiency

                                                                                                                                                                              3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                              ST-segment depression

                                                                                                                                                                              Flattening or inversion of P waves

                                                                                                                                                                              Torsades de pointes

                                                                                                                                                                              Arrhythmia

                                                                                                                                                                              Treatment

                                                                                                                                                                              1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                              2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                              Message for Today

                                                                                                                                                                              ICF

                                                                                                                                                                              Interstitial

                                                                                                                                                                              Pla

                                                                                                                                                                              sma

                                                                                                                                                                              5 Dex

                                                                                                                                                                              bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                              • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                              • Slide 2
                                                                                                                                                                              • Slide 3
                                                                                                                                                                              • Slide 4
                                                                                                                                                                              • Total Body Water
                                                                                                                                                                              • Body Fluid Compartments
                                                                                                                                                                              • Total body water (TBW)
                                                                                                                                                                              • Body compartment fluid
                                                                                                                                                                              • Example men with 70kg
                                                                                                                                                                              • Fluid compartments
                                                                                                                                                                              • Slide 11
                                                                                                                                                                              • Slide 12
                                                                                                                                                                              • Slide 13
                                                                                                                                                                              • Slide 14
                                                                                                                                                                              • Slide 15
                                                                                                                                                                              • Colloid osmotic pressure
                                                                                                                                                                              • Slide 17
                                                                                                                                                                              • Slide 18
                                                                                                                                                                              • Slide 19
                                                                                                                                                                              • Cell Membrane
                                                                                                                                                                              • Slide 21
                                                                                                                                                                              • Slide 22
                                                                                                                                                                              • Slide 23
                                                                                                                                                                              • Slide 24
                                                                                                                                                                              • Slide 25
                                                                                                                                                                              • Composition of Fluid Compartments
                                                                                                                                                                              • Composition of Body Fluids
                                                                                                                                                                              • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                              • Reasons for fluid therapy
                                                                                                                                                                              • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                              • محلولهای وریدی
                                                                                                                                                                              • Fluids
                                                                                                                                                                              • Slide 33
                                                                                                                                                                              • Slide 34
                                                                                                                                                                              • Slide 35
                                                                                                                                                                              • Crystalloids
                                                                                                                                                                              • Colloid Solutions
                                                                                                                                                                              • رینگر لاکتات
                                                                                                                                                                              • 09Nacl
                                                                                                                                                                              • Postoperative (maintenance)
                                                                                                                                                                              • Slide 41
                                                                                                                                                                              • Preexisting fluid deficits
                                                                                                                                                                              • Maintenance requirements
                                                                                                                                                                              • Surgical fluid losses
                                                                                                                                                                              • Third space loss
                                                                                                                                                                              • Crystalloid solution
                                                                                                                                                                              • Colloids
                                                                                                                                                                              • Complications
                                                                                                                                                                              • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                              • Colloid versus crystalloid solutions
                                                                                                                                                                              • Transfusion consideration
                                                                                                                                                                              • اختلال در حجم مایعات بدن
                                                                                                                                                                              • Fluid volume deficit (FVD)
                                                                                                                                                                              • DEHYDRATION
                                                                                                                                                                              • علل کاهش حجم خارج سلولی
                                                                                                                                                                              • Signs of Hypovolemia
                                                                                                                                                                              • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                              • Signs of Hypervolemia
                                                                                                                                                                              • Management of Hypervolemia
                                                                                                                                                                              • Fluid Management
                                                                                                                                                                              • Electrolyte physiology
                                                                                                                                                                              • Sodium physiology
                                                                                                                                                                              • Osmotic Pressure
                                                                                                                                                                              • Concentration
                                                                                                                                                                              • Hypernatremia
                                                                                                                                                                              • - Hypernatremia
                                                                                                                                                                              • Slide 67
                                                                                                                                                                              • Slide 68
                                                                                                                                                                              • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                              • Treatment
                                                                                                                                                                              • Water deficit (L)= times TBW
                                                                                                                                                                              • The rate of fluid administration
                                                                                                                                                                              • Hyponatremia Nalt135mEqL
                                                                                                                                                                              • Slide 74
                                                                                                                                                                              • Sodium depletion
                                                                                                                                                                              • Sodium dilution
                                                                                                                                                                              • Sign and symptoms
                                                                                                                                                                              • Slide 78
                                                                                                                                                                              • Treatment
                                                                                                                                                                              • Slide 80
                                                                                                                                                                              • Slide 81
                                                                                                                                                                              • Dose
                                                                                                                                                                              • Potassium abnormalities
                                                                                                                                                                              • Hyperkalemia
                                                                                                                                                                              • Clinical manifestation of hyperkalemia
                                                                                                                                                                              • Slide 86
                                                                                                                                                                              • Slide 87
                                                                                                                                                                              • Hypokalemia
                                                                                                                                                                              • Potassium changes associated with alkalosis
                                                                                                                                                                              • Slide 90
                                                                                                                                                                              • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                              • Slide 92
                                                                                                                                                                              • Calcium
                                                                                                                                                                              • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                              • علائم هیپوکلسمی
                                                                                                                                                                              • Slide 96
                                                                                                                                                                              • Slide 97
                                                                                                                                                                              • Slide 98
                                                                                                                                                                              • Slide 99
                                                                                                                                                                              • سایرعلائم
                                                                                                                                                                              • درمان
                                                                                                                                                                              • هيپركلسمي Cagt55meql
                                                                                                                                                                              • علائم
                                                                                                                                                                              • علائم قلبی
                                                                                                                                                                              • Slide 105
                                                                                                                                                                              • Magnesium Abnormalities
                                                                                                                                                                              • منیزیوم
                                                                                                                                                                              • Hypermagnesemia
                                                                                                                                                                              • Clinical manifestation hypermanesemia
                                                                                                                                                                              • Slide 110
                                                                                                                                                                              • Slide 111
                                                                                                                                                                              • Hypomagnesemia
                                                                                                                                                                              • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                              • Slide 114
                                                                                                                                                                              • Message for Today
                                                                                                                                                                              • Slide 116

                                                                                                                                                                                Magnesium Depletion

                                                                                                                                                                                (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                                                Renal potassium wastage

                                                                                                                                                                                Hypokalemia

                                                                                                                                                                                Magnesium Depletion

                                                                                                                                                                                (drug induced amphotericin amioglycosides cisplatin)

                                                                                                                                                                                Renal potassium wastage

                                                                                                                                                                                Hypokalemia

                                                                                                                                                                                Clinical Manifestation of Abnormalities in potassium

                                                                                                                                                                                System hypokalemia

                                                                                                                                                                                Gastrointestinal Ileus constipation

                                                                                                                                                                                Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                                                                paralysis

                                                                                                                                                                                Cardiovascular Arrest

                                                                                                                                                                                ECG changes U-waves

                                                                                                                                                                                T-wave flattening

                                                                                                                                                                                ST-segment changes

                                                                                                                                                                                Arrhythmias

                                                                                                                                                                                Treatment

                                                                                                                                                                                Potassium

                                                                                                                                                                                Serum potassium level lt40 mEqL

                                                                                                                                                                                Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                                                                times 1 doses

                                                                                                                                                                                Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                                                                Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                                                                Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                                                                asymptomatic replace as per above protocol

                                                                                                                                                                                Electrolyte Replacement Therapy Protocol

                                                                                                                                                                                bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                                                                bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                                                                Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                                                ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                                                عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                                                صاف 2 عضالت انقباض

                                                                                                                                                                                هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                                                انعقاد 4

                                                                                                                                                                                یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                                                عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                                                ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                                                میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                                                ( شود می پیوند شده

                                                                                                                                                                                هیپوکلسمی عالئم

                                                                                                                                                                                رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                                                سایرعالئم

                                                                                                                                                                                قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                                                درمان

                                                                                                                                                                                ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                                                Cagt55meql هيپركلسمي

                                                                                                                                                                                هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                                                عالئم

                                                                                                                                                                                bullGI

                                                                                                                                                                                bullCardiovascular bullRenal (polyuria)

                                                                                                                                                                                bullCNS

                                                                                                                                                                                قلبی عالئم

                                                                                                                                                                                bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                                                QRS شدن )Q-Tوكوتاه

                                                                                                                                                                                درمان

                                                                                                                                                                                ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                                الزیکس2

                                                                                                                                                                                تونین 3 کلسی

                                                                                                                                                                                کورتون4

                                                                                                                                                                                دیالیز5

                                                                                                                                                                                Magnesium Abnormalities

                                                                                                                                                                                Normal dietary intake 20meq (240mg)

                                                                                                                                                                                Excretion in both the feces and urine

                                                                                                                                                                                Normal serum level 19-25 mgdL

                                                                                                                                                                                منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                                تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                                bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                                Hypermagnesemia

                                                                                                                                                                                Etiology

                                                                                                                                                                                1 Impaired renal function

                                                                                                                                                                                2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                                Clinical manifestation hypermanesemia

                                                                                                                                                                                System hypermanesemia

                                                                                                                                                                                Gastrointestinal Nauseavomiting

                                                                                                                                                                                Neuromuscular weakness lethargy Decreased

                                                                                                                                                                                reflexes

                                                                                                                                                                                Cardiovascular Hypotension arrest

                                                                                                                                                                                ECG changes Increased PR interval

                                                                                                                                                                                Widened QRS complex

                                                                                                                                                                                Elevated T waves

                                                                                                                                                                                Treatment

                                                                                                                                                                                1 Withhold exogenous sources of magnesium

                                                                                                                                                                                2 Correct volume deficit

                                                                                                                                                                                3 Correct acidosis if present

                                                                                                                                                                                4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                                5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                                عالئم

                                                                                                                                                                                bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                                meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                                meqL

                                                                                                                                                                                Hypomagnesemia

                                                                                                                                                                                Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                                homeostasis

                                                                                                                                                                                Etiology

                                                                                                                                                                                1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                                inadequate supplementation of magnesium)

                                                                                                                                                                                2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                                3 GI losses (diarrhea)

                                                                                                                                                                                4 Malabsorption

                                                                                                                                                                                5 Acute pancreatitis

                                                                                                                                                                                6 Diabetic ketoacidosis

                                                                                                                                                                                7 Primary aldosteronism

                                                                                                                                                                                Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                2 Delirium and seizures in severe deficiency

                                                                                                                                                                                3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                ST-segment depression

                                                                                                                                                                                Flattening or inversion of P waves

                                                                                                                                                                                Torsades de pointes

                                                                                                                                                                                Arrhythmia

                                                                                                                                                                                Treatment

                                                                                                                                                                                1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                Message for Today

                                                                                                                                                                                ICF

                                                                                                                                                                                Interstitial

                                                                                                                                                                                Pla

                                                                                                                                                                                sma

                                                                                                                                                                                5 Dex

                                                                                                                                                                                bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                • Slide 2
                                                                                                                                                                                • Slide 3
                                                                                                                                                                                • Slide 4
                                                                                                                                                                                • Total Body Water
                                                                                                                                                                                • Body Fluid Compartments
                                                                                                                                                                                • Total body water (TBW)
                                                                                                                                                                                • Body compartment fluid
                                                                                                                                                                                • Example men with 70kg
                                                                                                                                                                                • Fluid compartments
                                                                                                                                                                                • Slide 11
                                                                                                                                                                                • Slide 12
                                                                                                                                                                                • Slide 13
                                                                                                                                                                                • Slide 14
                                                                                                                                                                                • Slide 15
                                                                                                                                                                                • Colloid osmotic pressure
                                                                                                                                                                                • Slide 17
                                                                                                                                                                                • Slide 18
                                                                                                                                                                                • Slide 19
                                                                                                                                                                                • Cell Membrane
                                                                                                                                                                                • Slide 21
                                                                                                                                                                                • Slide 22
                                                                                                                                                                                • Slide 23
                                                                                                                                                                                • Slide 24
                                                                                                                                                                                • Slide 25
                                                                                                                                                                                • Composition of Fluid Compartments
                                                                                                                                                                                • Composition of Body Fluids
                                                                                                                                                                                • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                • Reasons for fluid therapy
                                                                                                                                                                                • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                • محلولهای وریدی
                                                                                                                                                                                • Fluids
                                                                                                                                                                                • Slide 33
                                                                                                                                                                                • Slide 34
                                                                                                                                                                                • Slide 35
                                                                                                                                                                                • Crystalloids
                                                                                                                                                                                • Colloid Solutions
                                                                                                                                                                                • رینگر لاکتات
                                                                                                                                                                                • 09Nacl
                                                                                                                                                                                • Postoperative (maintenance)
                                                                                                                                                                                • Slide 41
                                                                                                                                                                                • Preexisting fluid deficits
                                                                                                                                                                                • Maintenance requirements
                                                                                                                                                                                • Surgical fluid losses
                                                                                                                                                                                • Third space loss
                                                                                                                                                                                • Crystalloid solution
                                                                                                                                                                                • Colloids
                                                                                                                                                                                • Complications
                                                                                                                                                                                • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                • Colloid versus crystalloid solutions
                                                                                                                                                                                • Transfusion consideration
                                                                                                                                                                                • اختلال در حجم مایعات بدن
                                                                                                                                                                                • Fluid volume deficit (FVD)
                                                                                                                                                                                • DEHYDRATION
                                                                                                                                                                                • علل کاهش حجم خارج سلولی
                                                                                                                                                                                • Signs of Hypovolemia
                                                                                                                                                                                • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                • Signs of Hypervolemia
                                                                                                                                                                                • Management of Hypervolemia
                                                                                                                                                                                • Fluid Management
                                                                                                                                                                                • Electrolyte physiology
                                                                                                                                                                                • Sodium physiology
                                                                                                                                                                                • Osmotic Pressure
                                                                                                                                                                                • Concentration
                                                                                                                                                                                • Hypernatremia
                                                                                                                                                                                • - Hypernatremia
                                                                                                                                                                                • Slide 67
                                                                                                                                                                                • Slide 68
                                                                                                                                                                                • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                • Treatment
                                                                                                                                                                                • Water deficit (L)= times TBW
                                                                                                                                                                                • The rate of fluid administration
                                                                                                                                                                                • Hyponatremia Nalt135mEqL
                                                                                                                                                                                • Slide 74
                                                                                                                                                                                • Sodium depletion
                                                                                                                                                                                • Sodium dilution
                                                                                                                                                                                • Sign and symptoms
                                                                                                                                                                                • Slide 78
                                                                                                                                                                                • Treatment
                                                                                                                                                                                • Slide 80
                                                                                                                                                                                • Slide 81
                                                                                                                                                                                • Dose
                                                                                                                                                                                • Potassium abnormalities
                                                                                                                                                                                • Hyperkalemia
                                                                                                                                                                                • Clinical manifestation of hyperkalemia
                                                                                                                                                                                • Slide 86
                                                                                                                                                                                • Slide 87
                                                                                                                                                                                • Hypokalemia
                                                                                                                                                                                • Potassium changes associated with alkalosis
                                                                                                                                                                                • Slide 90
                                                                                                                                                                                • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                • Slide 92
                                                                                                                                                                                • Calcium
                                                                                                                                                                                • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                • علائم هیپوکلسمی
                                                                                                                                                                                • Slide 96
                                                                                                                                                                                • Slide 97
                                                                                                                                                                                • Slide 98
                                                                                                                                                                                • Slide 99
                                                                                                                                                                                • سایرعلائم
                                                                                                                                                                                • درمان
                                                                                                                                                                                • هيپركلسمي Cagt55meql
                                                                                                                                                                                • علائم
                                                                                                                                                                                • علائم قلبی
                                                                                                                                                                                • Slide 105
                                                                                                                                                                                • Magnesium Abnormalities
                                                                                                                                                                                • منیزیوم
                                                                                                                                                                                • Hypermagnesemia
                                                                                                                                                                                • Clinical manifestation hypermanesemia
                                                                                                                                                                                • Slide 110
                                                                                                                                                                                • Slide 111
                                                                                                                                                                                • Hypomagnesemia
                                                                                                                                                                                • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                • Slide 114
                                                                                                                                                                                • Message for Today
                                                                                                                                                                                • Slide 116

                                                                                                                                                                                  Clinical Manifestation of Abnormalities in potassium

                                                                                                                                                                                  System hypokalemia

                                                                                                                                                                                  Gastrointestinal Ileus constipation

                                                                                                                                                                                  Neuromuscular Decreased reflexes fatigue weakness

                                                                                                                                                                                  paralysis

                                                                                                                                                                                  Cardiovascular Arrest

                                                                                                                                                                                  ECG changes U-waves

                                                                                                                                                                                  T-wave flattening

                                                                                                                                                                                  ST-segment changes

                                                                                                                                                                                  Arrhythmias

                                                                                                                                                                                  Treatment

                                                                                                                                                                                  Potassium

                                                                                                                                                                                  Serum potassium level lt40 mEqL

                                                                                                                                                                                  Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                                                                  times 1 doses

                                                                                                                                                                                  Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                                                                  Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                                                                  Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                                                                  asymptomatic replace as per above protocol

                                                                                                                                                                                  Electrolyte Replacement Therapy Protocol

                                                                                                                                                                                  bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                                                                  bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                                                                  Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                                                  ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                                                  عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                                                  صاف 2 عضالت انقباض

                                                                                                                                                                                  هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                                                  انعقاد 4

                                                                                                                                                                                  یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                                                  عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                                                  ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                                                  میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                                                  ( شود می پیوند شده

                                                                                                                                                                                  هیپوکلسمی عالئم

                                                                                                                                                                                  رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                                                  سایرعالئم

                                                                                                                                                                                  قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                                                  درمان

                                                                                                                                                                                  ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                                                  Cagt55meql هيپركلسمي

                                                                                                                                                                                  هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                                                  عالئم

                                                                                                                                                                                  bullGI

                                                                                                                                                                                  bullCardiovascular bullRenal (polyuria)

                                                                                                                                                                                  bullCNS

                                                                                                                                                                                  قلبی عالئم

                                                                                                                                                                                  bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                                                  QRS شدن )Q-Tوكوتاه

                                                                                                                                                                                  درمان

                                                                                                                                                                                  ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                                  الزیکس2

                                                                                                                                                                                  تونین 3 کلسی

                                                                                                                                                                                  کورتون4

                                                                                                                                                                                  دیالیز5

                                                                                                                                                                                  Magnesium Abnormalities

                                                                                                                                                                                  Normal dietary intake 20meq (240mg)

                                                                                                                                                                                  Excretion in both the feces and urine

                                                                                                                                                                                  Normal serum level 19-25 mgdL

                                                                                                                                                                                  منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                                  تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                                  bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                                  Hypermagnesemia

                                                                                                                                                                                  Etiology

                                                                                                                                                                                  1 Impaired renal function

                                                                                                                                                                                  2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                                  Clinical manifestation hypermanesemia

                                                                                                                                                                                  System hypermanesemia

                                                                                                                                                                                  Gastrointestinal Nauseavomiting

                                                                                                                                                                                  Neuromuscular weakness lethargy Decreased

                                                                                                                                                                                  reflexes

                                                                                                                                                                                  Cardiovascular Hypotension arrest

                                                                                                                                                                                  ECG changes Increased PR interval

                                                                                                                                                                                  Widened QRS complex

                                                                                                                                                                                  Elevated T waves

                                                                                                                                                                                  Treatment

                                                                                                                                                                                  1 Withhold exogenous sources of magnesium

                                                                                                                                                                                  2 Correct volume deficit

                                                                                                                                                                                  3 Correct acidosis if present

                                                                                                                                                                                  4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                                  5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                                  عالئم

                                                                                                                                                                                  bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                                  meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                                  meqL

                                                                                                                                                                                  Hypomagnesemia

                                                                                                                                                                                  Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                                  homeostasis

                                                                                                                                                                                  Etiology

                                                                                                                                                                                  1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                                  inadequate supplementation of magnesium)

                                                                                                                                                                                  2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                                  3 GI losses (diarrhea)

                                                                                                                                                                                  4 Malabsorption

                                                                                                                                                                                  5 Acute pancreatitis

                                                                                                                                                                                  6 Diabetic ketoacidosis

                                                                                                                                                                                  7 Primary aldosteronism

                                                                                                                                                                                  Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                  1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                  2 Delirium and seizures in severe deficiency

                                                                                                                                                                                  3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                  ST-segment depression

                                                                                                                                                                                  Flattening or inversion of P waves

                                                                                                                                                                                  Torsades de pointes

                                                                                                                                                                                  Arrhythmia

                                                                                                                                                                                  Treatment

                                                                                                                                                                                  1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                  2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                  Message for Today

                                                                                                                                                                                  ICF

                                                                                                                                                                                  Interstitial

                                                                                                                                                                                  Pla

                                                                                                                                                                                  sma

                                                                                                                                                                                  5 Dex

                                                                                                                                                                                  bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                  • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                  • Slide 2
                                                                                                                                                                                  • Slide 3
                                                                                                                                                                                  • Slide 4
                                                                                                                                                                                  • Total Body Water
                                                                                                                                                                                  • Body Fluid Compartments
                                                                                                                                                                                  • Total body water (TBW)
                                                                                                                                                                                  • Body compartment fluid
                                                                                                                                                                                  • Example men with 70kg
                                                                                                                                                                                  • Fluid compartments
                                                                                                                                                                                  • Slide 11
                                                                                                                                                                                  • Slide 12
                                                                                                                                                                                  • Slide 13
                                                                                                                                                                                  • Slide 14
                                                                                                                                                                                  • Slide 15
                                                                                                                                                                                  • Colloid osmotic pressure
                                                                                                                                                                                  • Slide 17
                                                                                                                                                                                  • Slide 18
                                                                                                                                                                                  • Slide 19
                                                                                                                                                                                  • Cell Membrane
                                                                                                                                                                                  • Slide 21
                                                                                                                                                                                  • Slide 22
                                                                                                                                                                                  • Slide 23
                                                                                                                                                                                  • Slide 24
                                                                                                                                                                                  • Slide 25
                                                                                                                                                                                  • Composition of Fluid Compartments
                                                                                                                                                                                  • Composition of Body Fluids
                                                                                                                                                                                  • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                  • Reasons for fluid therapy
                                                                                                                                                                                  • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                  • محلولهای وریدی
                                                                                                                                                                                  • Fluids
                                                                                                                                                                                  • Slide 33
                                                                                                                                                                                  • Slide 34
                                                                                                                                                                                  • Slide 35
                                                                                                                                                                                  • Crystalloids
                                                                                                                                                                                  • Colloid Solutions
                                                                                                                                                                                  • رینگر لاکتات
                                                                                                                                                                                  • 09Nacl
                                                                                                                                                                                  • Postoperative (maintenance)
                                                                                                                                                                                  • Slide 41
                                                                                                                                                                                  • Preexisting fluid deficits
                                                                                                                                                                                  • Maintenance requirements
                                                                                                                                                                                  • Surgical fluid losses
                                                                                                                                                                                  • Third space loss
                                                                                                                                                                                  • Crystalloid solution
                                                                                                                                                                                  • Colloids
                                                                                                                                                                                  • Complications
                                                                                                                                                                                  • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                  • Colloid versus crystalloid solutions
                                                                                                                                                                                  • Transfusion consideration
                                                                                                                                                                                  • اختلال در حجم مایعات بدن
                                                                                                                                                                                  • Fluid volume deficit (FVD)
                                                                                                                                                                                  • DEHYDRATION
                                                                                                                                                                                  • علل کاهش حجم خارج سلولی
                                                                                                                                                                                  • Signs of Hypovolemia
                                                                                                                                                                                  • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                  • Signs of Hypervolemia
                                                                                                                                                                                  • Management of Hypervolemia
                                                                                                                                                                                  • Fluid Management
                                                                                                                                                                                  • Electrolyte physiology
                                                                                                                                                                                  • Sodium physiology
                                                                                                                                                                                  • Osmotic Pressure
                                                                                                                                                                                  • Concentration
                                                                                                                                                                                  • Hypernatremia
                                                                                                                                                                                  • - Hypernatremia
                                                                                                                                                                                  • Slide 67
                                                                                                                                                                                  • Slide 68
                                                                                                                                                                                  • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                  • Treatment
                                                                                                                                                                                  • Water deficit (L)= times TBW
                                                                                                                                                                                  • The rate of fluid administration
                                                                                                                                                                                  • Hyponatremia Nalt135mEqL
                                                                                                                                                                                  • Slide 74
                                                                                                                                                                                  • Sodium depletion
                                                                                                                                                                                  • Sodium dilution
                                                                                                                                                                                  • Sign and symptoms
                                                                                                                                                                                  • Slide 78
                                                                                                                                                                                  • Treatment
                                                                                                                                                                                  • Slide 80
                                                                                                                                                                                  • Slide 81
                                                                                                                                                                                  • Dose
                                                                                                                                                                                  • Potassium abnormalities
                                                                                                                                                                                  • Hyperkalemia
                                                                                                                                                                                  • Clinical manifestation of hyperkalemia
                                                                                                                                                                                  • Slide 86
                                                                                                                                                                                  • Slide 87
                                                                                                                                                                                  • Hypokalemia
                                                                                                                                                                                  • Potassium changes associated with alkalosis
                                                                                                                                                                                  • Slide 90
                                                                                                                                                                                  • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                  • Slide 92
                                                                                                                                                                                  • Calcium
                                                                                                                                                                                  • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                  • علائم هیپوکلسمی
                                                                                                                                                                                  • Slide 96
                                                                                                                                                                                  • Slide 97
                                                                                                                                                                                  • Slide 98
                                                                                                                                                                                  • Slide 99
                                                                                                                                                                                  • سایرعلائم
                                                                                                                                                                                  • درمان
                                                                                                                                                                                  • هيپركلسمي Cagt55meql
                                                                                                                                                                                  • علائم
                                                                                                                                                                                  • علائم قلبی
                                                                                                                                                                                  • Slide 105
                                                                                                                                                                                  • Magnesium Abnormalities
                                                                                                                                                                                  • منیزیوم
                                                                                                                                                                                  • Hypermagnesemia
                                                                                                                                                                                  • Clinical manifestation hypermanesemia
                                                                                                                                                                                  • Slide 110
                                                                                                                                                                                  • Slide 111
                                                                                                                                                                                  • Hypomagnesemia
                                                                                                                                                                                  • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                  • Slide 114
                                                                                                                                                                                  • Message for Today
                                                                                                                                                                                  • Slide 116

                                                                                                                                                                                    Treatment

                                                                                                                                                                                    Potassium

                                                                                                                                                                                    Serum potassium level lt40 mEqL

                                                                                                                                                                                    Asymptomatic tolerating enteral nutrition KC1 40 mEq per entral access

                                                                                                                                                                                    times 1 doses

                                                                                                                                                                                    Asymptomatic not tolerating entral nutrition KC1 20 mEq IV q2h times 2 doses

                                                                                                                                                                                    Symptomatic KC1 20 mEq IV q1h times 4 doses

                                                                                                                                                                                    Recheck potassium level 2 hours after end of infusion if lt35 mEqL and

                                                                                                                                                                                    asymptomatic replace as per above protocol

                                                                                                                                                                                    Electrolyte Replacement Therapy Protocol

                                                                                                                                                                                    bull Oral repletion for mild and asymptomatic hypokalemia

                                                                                                                                                                                    bull IV repletion for severe and symptomatic hypokalemia

                                                                                                                                                                                    Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                                                    ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                                                    عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                                                    صاف 2 عضالت انقباض

                                                                                                                                                                                    هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                                                    انعقاد 4

                                                                                                                                                                                    یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                                                    عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                                                    ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                                                    میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                                                    ( شود می پیوند شده

                                                                                                                                                                                    هیپوکلسمی عالئم

                                                                                                                                                                                    رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                                                    سایرعالئم

                                                                                                                                                                                    قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                                                    درمان

                                                                                                                                                                                    ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                                                    Cagt55meql هيپركلسمي

                                                                                                                                                                                    هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                                                    عالئم

                                                                                                                                                                                    bullGI

                                                                                                                                                                                    bullCardiovascular bullRenal (polyuria)

                                                                                                                                                                                    bullCNS

                                                                                                                                                                                    قلبی عالئم

                                                                                                                                                                                    bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                                                    QRS شدن )Q-Tوكوتاه

                                                                                                                                                                                    درمان

                                                                                                                                                                                    ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                                    الزیکس2

                                                                                                                                                                                    تونین 3 کلسی

                                                                                                                                                                                    کورتون4

                                                                                                                                                                                    دیالیز5

                                                                                                                                                                                    Magnesium Abnormalities

                                                                                                                                                                                    Normal dietary intake 20meq (240mg)

                                                                                                                                                                                    Excretion in both the feces and urine

                                                                                                                                                                                    Normal serum level 19-25 mgdL

                                                                                                                                                                                    منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                                    تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                                    bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                                    Hypermagnesemia

                                                                                                                                                                                    Etiology

                                                                                                                                                                                    1 Impaired renal function

                                                                                                                                                                                    2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                                    Clinical manifestation hypermanesemia

                                                                                                                                                                                    System hypermanesemia

                                                                                                                                                                                    Gastrointestinal Nauseavomiting

                                                                                                                                                                                    Neuromuscular weakness lethargy Decreased

                                                                                                                                                                                    reflexes

                                                                                                                                                                                    Cardiovascular Hypotension arrest

                                                                                                                                                                                    ECG changes Increased PR interval

                                                                                                                                                                                    Widened QRS complex

                                                                                                                                                                                    Elevated T waves

                                                                                                                                                                                    Treatment

                                                                                                                                                                                    1 Withhold exogenous sources of magnesium

                                                                                                                                                                                    2 Correct volume deficit

                                                                                                                                                                                    3 Correct acidosis if present

                                                                                                                                                                                    4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                                    5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                                    عالئم

                                                                                                                                                                                    bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                                    meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                                    meqL

                                                                                                                                                                                    Hypomagnesemia

                                                                                                                                                                                    Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                                    homeostasis

                                                                                                                                                                                    Etiology

                                                                                                                                                                                    1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                                    inadequate supplementation of magnesium)

                                                                                                                                                                                    2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                                    3 GI losses (diarrhea)

                                                                                                                                                                                    4 Malabsorption

                                                                                                                                                                                    5 Acute pancreatitis

                                                                                                                                                                                    6 Diabetic ketoacidosis

                                                                                                                                                                                    7 Primary aldosteronism

                                                                                                                                                                                    Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                    1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                    2 Delirium and seizures in severe deficiency

                                                                                                                                                                                    3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                    ST-segment depression

                                                                                                                                                                                    Flattening or inversion of P waves

                                                                                                                                                                                    Torsades de pointes

                                                                                                                                                                                    Arrhythmia

                                                                                                                                                                                    Treatment

                                                                                                                                                                                    1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                    2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                    Message for Today

                                                                                                                                                                                    ICF

                                                                                                                                                                                    Interstitial

                                                                                                                                                                                    Pla

                                                                                                                                                                                    sma

                                                                                                                                                                                    5 Dex

                                                                                                                                                                                    bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                    • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                    • Slide 2
                                                                                                                                                                                    • Slide 3
                                                                                                                                                                                    • Slide 4
                                                                                                                                                                                    • Total Body Water
                                                                                                                                                                                    • Body Fluid Compartments
                                                                                                                                                                                    • Total body water (TBW)
                                                                                                                                                                                    • Body compartment fluid
                                                                                                                                                                                    • Example men with 70kg
                                                                                                                                                                                    • Fluid compartments
                                                                                                                                                                                    • Slide 11
                                                                                                                                                                                    • Slide 12
                                                                                                                                                                                    • Slide 13
                                                                                                                                                                                    • Slide 14
                                                                                                                                                                                    • Slide 15
                                                                                                                                                                                    • Colloid osmotic pressure
                                                                                                                                                                                    • Slide 17
                                                                                                                                                                                    • Slide 18
                                                                                                                                                                                    • Slide 19
                                                                                                                                                                                    • Cell Membrane
                                                                                                                                                                                    • Slide 21
                                                                                                                                                                                    • Slide 22
                                                                                                                                                                                    • Slide 23
                                                                                                                                                                                    • Slide 24
                                                                                                                                                                                    • Slide 25
                                                                                                                                                                                    • Composition of Fluid Compartments
                                                                                                                                                                                    • Composition of Body Fluids
                                                                                                                                                                                    • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                    • Reasons for fluid therapy
                                                                                                                                                                                    • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                    • محلولهای وریدی
                                                                                                                                                                                    • Fluids
                                                                                                                                                                                    • Slide 33
                                                                                                                                                                                    • Slide 34
                                                                                                                                                                                    • Slide 35
                                                                                                                                                                                    • Crystalloids
                                                                                                                                                                                    • Colloid Solutions
                                                                                                                                                                                    • رینگر لاکتات
                                                                                                                                                                                    • 09Nacl
                                                                                                                                                                                    • Postoperative (maintenance)
                                                                                                                                                                                    • Slide 41
                                                                                                                                                                                    • Preexisting fluid deficits
                                                                                                                                                                                    • Maintenance requirements
                                                                                                                                                                                    • Surgical fluid losses
                                                                                                                                                                                    • Third space loss
                                                                                                                                                                                    • Crystalloid solution
                                                                                                                                                                                    • Colloids
                                                                                                                                                                                    • Complications
                                                                                                                                                                                    • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                    • Colloid versus crystalloid solutions
                                                                                                                                                                                    • Transfusion consideration
                                                                                                                                                                                    • اختلال در حجم مایعات بدن
                                                                                                                                                                                    • Fluid volume deficit (FVD)
                                                                                                                                                                                    • DEHYDRATION
                                                                                                                                                                                    • علل کاهش حجم خارج سلولی
                                                                                                                                                                                    • Signs of Hypovolemia
                                                                                                                                                                                    • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                    • Signs of Hypervolemia
                                                                                                                                                                                    • Management of Hypervolemia
                                                                                                                                                                                    • Fluid Management
                                                                                                                                                                                    • Electrolyte physiology
                                                                                                                                                                                    • Sodium physiology
                                                                                                                                                                                    • Osmotic Pressure
                                                                                                                                                                                    • Concentration
                                                                                                                                                                                    • Hypernatremia
                                                                                                                                                                                    • - Hypernatremia
                                                                                                                                                                                    • Slide 67
                                                                                                                                                                                    • Slide 68
                                                                                                                                                                                    • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                    • Treatment
                                                                                                                                                                                    • Water deficit (L)= times TBW
                                                                                                                                                                                    • The rate of fluid administration
                                                                                                                                                                                    • Hyponatremia Nalt135mEqL
                                                                                                                                                                                    • Slide 74
                                                                                                                                                                                    • Sodium depletion
                                                                                                                                                                                    • Sodium dilution
                                                                                                                                                                                    • Sign and symptoms
                                                                                                                                                                                    • Slide 78
                                                                                                                                                                                    • Treatment
                                                                                                                                                                                    • Slide 80
                                                                                                                                                                                    • Slide 81
                                                                                                                                                                                    • Dose
                                                                                                                                                                                    • Potassium abnormalities
                                                                                                                                                                                    • Hyperkalemia
                                                                                                                                                                                    • Clinical manifestation of hyperkalemia
                                                                                                                                                                                    • Slide 86
                                                                                                                                                                                    • Slide 87
                                                                                                                                                                                    • Hypokalemia
                                                                                                                                                                                    • Potassium changes associated with alkalosis
                                                                                                                                                                                    • Slide 90
                                                                                                                                                                                    • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                    • Slide 92
                                                                                                                                                                                    • Calcium
                                                                                                                                                                                    • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                    • علائم هیپوکلسمی
                                                                                                                                                                                    • Slide 96
                                                                                                                                                                                    • Slide 97
                                                                                                                                                                                    • Slide 98
                                                                                                                                                                                    • Slide 99
                                                                                                                                                                                    • سایرعلائم
                                                                                                                                                                                    • درمان
                                                                                                                                                                                    • هيپركلسمي Cagt55meql
                                                                                                                                                                                    • علائم
                                                                                                                                                                                    • علائم قلبی
                                                                                                                                                                                    • Slide 105
                                                                                                                                                                                    • Magnesium Abnormalities
                                                                                                                                                                                    • منیزیوم
                                                                                                                                                                                    • Hypermagnesemia
                                                                                                                                                                                    • Clinical manifestation hypermanesemia
                                                                                                                                                                                    • Slide 110
                                                                                                                                                                                    • Slide 111
                                                                                                                                                                                    • Hypomagnesemia
                                                                                                                                                                                    • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                    • Slide 114
                                                                                                                                                                                    • Message for Today
                                                                                                                                                                                    • Slide 116

                                                                                                                                                                                      Calcium از bull است 99بيش اسكلتي سيستم در بدن كلسيم از

                                                                                                                                                                                      ( دندانها( ndash استخوانbull كلسيم نقش

                                                                                                                                                                                      عصبي 1 ايمپالسهاي )NMJ(انتقال

                                                                                                                                                                                      صاف 2 عضالت انقباض

                                                                                                                                                                                      هاي 3 واكنش برای الزم آنزيمهاي آزادسازي مسببشيميائي

                                                                                                                                                                                      انعقاد 4

                                                                                                                                                                                      یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                                                      عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                                                      ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                                                      میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                                                      ( شود می پیوند شده

                                                                                                                                                                                      هیپوکلسمی عالئم

                                                                                                                                                                                      رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                                                      سایرعالئم

                                                                                                                                                                                      قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                                                      درمان

                                                                                                                                                                                      ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                                                      Cagt55meql هيپركلسمي

                                                                                                                                                                                      هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                                                      عالئم

                                                                                                                                                                                      bullGI

                                                                                                                                                                                      bullCardiovascular bullRenal (polyuria)

                                                                                                                                                                                      bullCNS

                                                                                                                                                                                      قلبی عالئم

                                                                                                                                                                                      bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                                                      QRS شدن )Q-Tوكوتاه

                                                                                                                                                                                      درمان

                                                                                                                                                                                      ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                                      الزیکس2

                                                                                                                                                                                      تونین 3 کلسی

                                                                                                                                                                                      کورتون4

                                                                                                                                                                                      دیالیز5

                                                                                                                                                                                      Magnesium Abnormalities

                                                                                                                                                                                      Normal dietary intake 20meq (240mg)

                                                                                                                                                                                      Excretion in both the feces and urine

                                                                                                                                                                                      Normal serum level 19-25 mgdL

                                                                                                                                                                                      منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                                      تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                                      bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                                      Hypermagnesemia

                                                                                                                                                                                      Etiology

                                                                                                                                                                                      1 Impaired renal function

                                                                                                                                                                                      2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                                      Clinical manifestation hypermanesemia

                                                                                                                                                                                      System hypermanesemia

                                                                                                                                                                                      Gastrointestinal Nauseavomiting

                                                                                                                                                                                      Neuromuscular weakness lethargy Decreased

                                                                                                                                                                                      reflexes

                                                                                                                                                                                      Cardiovascular Hypotension arrest

                                                                                                                                                                                      ECG changes Increased PR interval

                                                                                                                                                                                      Widened QRS complex

                                                                                                                                                                                      Elevated T waves

                                                                                                                                                                                      Treatment

                                                                                                                                                                                      1 Withhold exogenous sources of magnesium

                                                                                                                                                                                      2 Correct volume deficit

                                                                                                                                                                                      3 Correct acidosis if present

                                                                                                                                                                                      4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                                      5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                                      عالئم

                                                                                                                                                                                      bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                                      meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                                      meqL

                                                                                                                                                                                      Hypomagnesemia

                                                                                                                                                                                      Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                                      homeostasis

                                                                                                                                                                                      Etiology

                                                                                                                                                                                      1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                                      inadequate supplementation of magnesium)

                                                                                                                                                                                      2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                                      3 GI losses (diarrhea)

                                                                                                                                                                                      4 Malabsorption

                                                                                                                                                                                      5 Acute pancreatitis

                                                                                                                                                                                      6 Diabetic ketoacidosis

                                                                                                                                                                                      7 Primary aldosteronism

                                                                                                                                                                                      Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                      1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                      2 Delirium and seizures in severe deficiency

                                                                                                                                                                                      3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                      ST-segment depression

                                                                                                                                                                                      Flattening or inversion of P waves

                                                                                                                                                                                      Torsades de pointes

                                                                                                                                                                                      Arrhythmia

                                                                                                                                                                                      Treatment

                                                                                                                                                                                      1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                      2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                      Message for Today

                                                                                                                                                                                      ICF

                                                                                                                                                                                      Interstitial

                                                                                                                                                                                      Pla

                                                                                                                                                                                      sma

                                                                                                                                                                                      5 Dex

                                                                                                                                                                                      bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                      • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                      • Slide 2
                                                                                                                                                                                      • Slide 3
                                                                                                                                                                                      • Slide 4
                                                                                                                                                                                      • Total Body Water
                                                                                                                                                                                      • Body Fluid Compartments
                                                                                                                                                                                      • Total body water (TBW)
                                                                                                                                                                                      • Body compartment fluid
                                                                                                                                                                                      • Example men with 70kg
                                                                                                                                                                                      • Fluid compartments
                                                                                                                                                                                      • Slide 11
                                                                                                                                                                                      • Slide 12
                                                                                                                                                                                      • Slide 13
                                                                                                                                                                                      • Slide 14
                                                                                                                                                                                      • Slide 15
                                                                                                                                                                                      • Colloid osmotic pressure
                                                                                                                                                                                      • Slide 17
                                                                                                                                                                                      • Slide 18
                                                                                                                                                                                      • Slide 19
                                                                                                                                                                                      • Cell Membrane
                                                                                                                                                                                      • Slide 21
                                                                                                                                                                                      • Slide 22
                                                                                                                                                                                      • Slide 23
                                                                                                                                                                                      • Slide 24
                                                                                                                                                                                      • Slide 25
                                                                                                                                                                                      • Composition of Fluid Compartments
                                                                                                                                                                                      • Composition of Body Fluids
                                                                                                                                                                                      • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                      • Reasons for fluid therapy
                                                                                                                                                                                      • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                      • محلولهای وریدی
                                                                                                                                                                                      • Fluids
                                                                                                                                                                                      • Slide 33
                                                                                                                                                                                      • Slide 34
                                                                                                                                                                                      • Slide 35
                                                                                                                                                                                      • Crystalloids
                                                                                                                                                                                      • Colloid Solutions
                                                                                                                                                                                      • رینگر لاکتات
                                                                                                                                                                                      • 09Nacl
                                                                                                                                                                                      • Postoperative (maintenance)
                                                                                                                                                                                      • Slide 41
                                                                                                                                                                                      • Preexisting fluid deficits
                                                                                                                                                                                      • Maintenance requirements
                                                                                                                                                                                      • Surgical fluid losses
                                                                                                                                                                                      • Third space loss
                                                                                                                                                                                      • Crystalloid solution
                                                                                                                                                                                      • Colloids
                                                                                                                                                                                      • Complications
                                                                                                                                                                                      • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                      • Colloid versus crystalloid solutions
                                                                                                                                                                                      • Transfusion consideration
                                                                                                                                                                                      • اختلال در حجم مایعات بدن
                                                                                                                                                                                      • Fluid volume deficit (FVD)
                                                                                                                                                                                      • DEHYDRATION
                                                                                                                                                                                      • علل کاهش حجم خارج سلولی
                                                                                                                                                                                      • Signs of Hypovolemia
                                                                                                                                                                                      • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                      • Signs of Hypervolemia
                                                                                                                                                                                      • Management of Hypervolemia
                                                                                                                                                                                      • Fluid Management
                                                                                                                                                                                      • Electrolyte physiology
                                                                                                                                                                                      • Sodium physiology
                                                                                                                                                                                      • Osmotic Pressure
                                                                                                                                                                                      • Concentration
                                                                                                                                                                                      • Hypernatremia
                                                                                                                                                                                      • - Hypernatremia
                                                                                                                                                                                      • Slide 67
                                                                                                                                                                                      • Slide 68
                                                                                                                                                                                      • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                      • Treatment
                                                                                                                                                                                      • Water deficit (L)= times TBW
                                                                                                                                                                                      • The rate of fluid administration
                                                                                                                                                                                      • Hyponatremia Nalt135mEqL
                                                                                                                                                                                      • Slide 74
                                                                                                                                                                                      • Sodium depletion
                                                                                                                                                                                      • Sodium dilution
                                                                                                                                                                                      • Sign and symptoms
                                                                                                                                                                                      • Slide 78
                                                                                                                                                                                      • Treatment
                                                                                                                                                                                      • Slide 80
                                                                                                                                                                                      • Slide 81
                                                                                                                                                                                      • Dose
                                                                                                                                                                                      • Potassium abnormalities
                                                                                                                                                                                      • Hyperkalemia
                                                                                                                                                                                      • Clinical manifestation of hyperkalemia
                                                                                                                                                                                      • Slide 86
                                                                                                                                                                                      • Slide 87
                                                                                                                                                                                      • Hypokalemia
                                                                                                                                                                                      • Potassium changes associated with alkalosis
                                                                                                                                                                                      • Slide 90
                                                                                                                                                                                      • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                      • Slide 92
                                                                                                                                                                                      • Calcium
                                                                                                                                                                                      • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                      • علائم هیپوکلسمی
                                                                                                                                                                                      • Slide 96
                                                                                                                                                                                      • Slide 97
                                                                                                                                                                                      • Slide 98
                                                                                                                                                                                      • Slide 99
                                                                                                                                                                                      • سایرعلائم
                                                                                                                                                                                      • درمان
                                                                                                                                                                                      • هيپركلسمي Cagt55meql
                                                                                                                                                                                      • علائم
                                                                                                                                                                                      • علائم قلبی
                                                                                                                                                                                      • Slide 105
                                                                                                                                                                                      • Magnesium Abnormalities
                                                                                                                                                                                      • منیزیوم
                                                                                                                                                                                      • Hypermagnesemia
                                                                                                                                                                                      • Clinical manifestation hypermanesemia
                                                                                                                                                                                      • Slide 110
                                                                                                                                                                                      • Slide 111
                                                                                                                                                                                      • Hypomagnesemia
                                                                                                                                                                                      • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                      • Slide 114
                                                                                                                                                                                      • Message for Today
                                                                                                                                                                                      • Slide 116

                                                                                                                                                                                        یونیزه Calt45 meql هيپوكلسمي

                                                                                                                                                                                        عللbullپاراتيروئيد 1 كاري كمپانكراتيت2ویتامین ( 3 تبدیل شدن مختل و فسفر احتباس كليه به Dنارسائي

                                                                                                                                                                                        ( کلیه در فعالش فرم4 ( کلسیم ( شدن باند افزایش باعث تنفسي آلكالوز هيپرونتيالسيون

                                                                                                                                                                                        میشود آلبومین باماسيو 5 ترانسفيو زن6( پاراتورمون ( ترشح مهار منیزیوم تخلیهتزریق ( 7 بیکربنات با مستقبم طور به کلسیم بیکربنات انفوزیون

                                                                                                                                                                                        ( شود می پیوند شده

                                                                                                                                                                                        هیپوکلسمی عالئم

                                                                                                                                                                                        رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                                                        سایرعالئم

                                                                                                                                                                                        قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                                                        درمان

                                                                                                                                                                                        ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                                                        Cagt55meql هيپركلسمي

                                                                                                                                                                                        هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                                                        عالئم

                                                                                                                                                                                        bullGI

                                                                                                                                                                                        bullCardiovascular bullRenal (polyuria)

                                                                                                                                                                                        bullCNS

                                                                                                                                                                                        قلبی عالئم

                                                                                                                                                                                        bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                                                        QRS شدن )Q-Tوكوتاه

                                                                                                                                                                                        درمان

                                                                                                                                                                                        ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                                        الزیکس2

                                                                                                                                                                                        تونین 3 کلسی

                                                                                                                                                                                        کورتون4

                                                                                                                                                                                        دیالیز5

                                                                                                                                                                                        Magnesium Abnormalities

                                                                                                                                                                                        Normal dietary intake 20meq (240mg)

                                                                                                                                                                                        Excretion in both the feces and urine

                                                                                                                                                                                        Normal serum level 19-25 mgdL

                                                                                                                                                                                        منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                                        تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                                        bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                                        Hypermagnesemia

                                                                                                                                                                                        Etiology

                                                                                                                                                                                        1 Impaired renal function

                                                                                                                                                                                        2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                                        Clinical manifestation hypermanesemia

                                                                                                                                                                                        System hypermanesemia

                                                                                                                                                                                        Gastrointestinal Nauseavomiting

                                                                                                                                                                                        Neuromuscular weakness lethargy Decreased

                                                                                                                                                                                        reflexes

                                                                                                                                                                                        Cardiovascular Hypotension arrest

                                                                                                                                                                                        ECG changes Increased PR interval

                                                                                                                                                                                        Widened QRS complex

                                                                                                                                                                                        Elevated T waves

                                                                                                                                                                                        Treatment

                                                                                                                                                                                        1 Withhold exogenous sources of magnesium

                                                                                                                                                                                        2 Correct volume deficit

                                                                                                                                                                                        3 Correct acidosis if present

                                                                                                                                                                                        4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                                        5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                                        عالئم

                                                                                                                                                                                        bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                                        meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                                        meqL

                                                                                                                                                                                        Hypomagnesemia

                                                                                                                                                                                        Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                                        homeostasis

                                                                                                                                                                                        Etiology

                                                                                                                                                                                        1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                                        inadequate supplementation of magnesium)

                                                                                                                                                                                        2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                                        3 GI losses (diarrhea)

                                                                                                                                                                                        4 Malabsorption

                                                                                                                                                                                        5 Acute pancreatitis

                                                                                                                                                                                        6 Diabetic ketoacidosis

                                                                                                                                                                                        7 Primary aldosteronism

                                                                                                                                                                                        Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                        1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                        2 Delirium and seizures in severe deficiency

                                                                                                                                                                                        3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                        ST-segment depression

                                                                                                                                                                                        Flattening or inversion of P waves

                                                                                                                                                                                        Torsades de pointes

                                                                                                                                                                                        Arrhythmia

                                                                                                                                                                                        Treatment

                                                                                                                                                                                        1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                        2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                        Message for Today

                                                                                                                                                                                        ICF

                                                                                                                                                                                        Interstitial

                                                                                                                                                                                        Pla

                                                                                                                                                                                        sma

                                                                                                                                                                                        5 Dex

                                                                                                                                                                                        bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                        • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                        • Slide 2
                                                                                                                                                                                        • Slide 3
                                                                                                                                                                                        • Slide 4
                                                                                                                                                                                        • Total Body Water
                                                                                                                                                                                        • Body Fluid Compartments
                                                                                                                                                                                        • Total body water (TBW)
                                                                                                                                                                                        • Body compartment fluid
                                                                                                                                                                                        • Example men with 70kg
                                                                                                                                                                                        • Fluid compartments
                                                                                                                                                                                        • Slide 11
                                                                                                                                                                                        • Slide 12
                                                                                                                                                                                        • Slide 13
                                                                                                                                                                                        • Slide 14
                                                                                                                                                                                        • Slide 15
                                                                                                                                                                                        • Colloid osmotic pressure
                                                                                                                                                                                        • Slide 17
                                                                                                                                                                                        • Slide 18
                                                                                                                                                                                        • Slide 19
                                                                                                                                                                                        • Cell Membrane
                                                                                                                                                                                        • Slide 21
                                                                                                                                                                                        • Slide 22
                                                                                                                                                                                        • Slide 23
                                                                                                                                                                                        • Slide 24
                                                                                                                                                                                        • Slide 25
                                                                                                                                                                                        • Composition of Fluid Compartments
                                                                                                                                                                                        • Composition of Body Fluids
                                                                                                                                                                                        • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                        • Reasons for fluid therapy
                                                                                                                                                                                        • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                        • محلولهای وریدی
                                                                                                                                                                                        • Fluids
                                                                                                                                                                                        • Slide 33
                                                                                                                                                                                        • Slide 34
                                                                                                                                                                                        • Slide 35
                                                                                                                                                                                        • Crystalloids
                                                                                                                                                                                        • Colloid Solutions
                                                                                                                                                                                        • رینگر لاکتات
                                                                                                                                                                                        • 09Nacl
                                                                                                                                                                                        • Postoperative (maintenance)
                                                                                                                                                                                        • Slide 41
                                                                                                                                                                                        • Preexisting fluid deficits
                                                                                                                                                                                        • Maintenance requirements
                                                                                                                                                                                        • Surgical fluid losses
                                                                                                                                                                                        • Third space loss
                                                                                                                                                                                        • Crystalloid solution
                                                                                                                                                                                        • Colloids
                                                                                                                                                                                        • Complications
                                                                                                                                                                                        • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                        • Colloid versus crystalloid solutions
                                                                                                                                                                                        • Transfusion consideration
                                                                                                                                                                                        • اختلال در حجم مایعات بدن
                                                                                                                                                                                        • Fluid volume deficit (FVD)
                                                                                                                                                                                        • DEHYDRATION
                                                                                                                                                                                        • علل کاهش حجم خارج سلولی
                                                                                                                                                                                        • Signs of Hypovolemia
                                                                                                                                                                                        • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                        • Signs of Hypervolemia
                                                                                                                                                                                        • Management of Hypervolemia
                                                                                                                                                                                        • Fluid Management
                                                                                                                                                                                        • Electrolyte physiology
                                                                                                                                                                                        • Sodium physiology
                                                                                                                                                                                        • Osmotic Pressure
                                                                                                                                                                                        • Concentration
                                                                                                                                                                                        • Hypernatremia
                                                                                                                                                                                        • - Hypernatremia
                                                                                                                                                                                        • Slide 67
                                                                                                                                                                                        • Slide 68
                                                                                                                                                                                        • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                        • Treatment
                                                                                                                                                                                        • Water deficit (L)= times TBW
                                                                                                                                                                                        • The rate of fluid administration
                                                                                                                                                                                        • Hyponatremia Nalt135mEqL
                                                                                                                                                                                        • Slide 74
                                                                                                                                                                                        • Sodium depletion
                                                                                                                                                                                        • Sodium dilution
                                                                                                                                                                                        • Sign and symptoms
                                                                                                                                                                                        • Slide 78
                                                                                                                                                                                        • Treatment
                                                                                                                                                                                        • Slide 80
                                                                                                                                                                                        • Slide 81
                                                                                                                                                                                        • Dose
                                                                                                                                                                                        • Potassium abnormalities
                                                                                                                                                                                        • Hyperkalemia
                                                                                                                                                                                        • Clinical manifestation of hyperkalemia
                                                                                                                                                                                        • Slide 86
                                                                                                                                                                                        • Slide 87
                                                                                                                                                                                        • Hypokalemia
                                                                                                                                                                                        • Potassium changes associated with alkalosis
                                                                                                                                                                                        • Slide 90
                                                                                                                                                                                        • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                        • Slide 92
                                                                                                                                                                                        • Calcium
                                                                                                                                                                                        • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                        • علائم هیپوکلسمی
                                                                                                                                                                                        • Slide 96
                                                                                                                                                                                        • Slide 97
                                                                                                                                                                                        • Slide 98
                                                                                                                                                                                        • Slide 99
                                                                                                                                                                                        • سایرعلائم
                                                                                                                                                                                        • درمان
                                                                                                                                                                                        • هيپركلسمي Cagt55meql
                                                                                                                                                                                        • علائم
                                                                                                                                                                                        • علائم قلبی
                                                                                                                                                                                        • Slide 105
                                                                                                                                                                                        • Magnesium Abnormalities
                                                                                                                                                                                        • منیزیوم
                                                                                                                                                                                        • Hypermagnesemia
                                                                                                                                                                                        • Clinical manifestation hypermanesemia
                                                                                                                                                                                        • Slide 110
                                                                                                                                                                                        • Slide 111
                                                                                                                                                                                        • Hypomagnesemia
                                                                                                                                                                                        • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                        • Slide 114
                                                                                                                                                                                        • Message for Today
                                                                                                                                                                                        • Slide 116

                                                                                                                                                                                          هیپوکلسمی عالئم

                                                                                                                                                                                          رفلکسی bull هیپرتشنجbullتتانیbullbullChevostek) 25( دارد وجود نرمال افرادbullTrousseau )30در ( ندارد وجود هیپوکلسمی مواردهیپوتانسیونbullقلبی bull ده برون کاهشآریتمیbull

                                                                                                                                                                                          سایرعالئم

                                                                                                                                                                                          قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                                                          درمان

                                                                                                                                                                                          ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                                                          Cagt55meql هيپركلسمي

                                                                                                                                                                                          هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                                                          عالئم

                                                                                                                                                                                          bullGI

                                                                                                                                                                                          bullCardiovascular bullRenal (polyuria)

                                                                                                                                                                                          bullCNS

                                                                                                                                                                                          قلبی عالئم

                                                                                                                                                                                          bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                                                          QRS شدن )Q-Tوكوتاه

                                                                                                                                                                                          درمان

                                                                                                                                                                                          ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                                          الزیکس2

                                                                                                                                                                                          تونین 3 کلسی

                                                                                                                                                                                          کورتون4

                                                                                                                                                                                          دیالیز5

                                                                                                                                                                                          Magnesium Abnormalities

                                                                                                                                                                                          Normal dietary intake 20meq (240mg)

                                                                                                                                                                                          Excretion in both the feces and urine

                                                                                                                                                                                          Normal serum level 19-25 mgdL

                                                                                                                                                                                          منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                                          تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                                          bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                                          Hypermagnesemia

                                                                                                                                                                                          Etiology

                                                                                                                                                                                          1 Impaired renal function

                                                                                                                                                                                          2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                                          Clinical manifestation hypermanesemia

                                                                                                                                                                                          System hypermanesemia

                                                                                                                                                                                          Gastrointestinal Nauseavomiting

                                                                                                                                                                                          Neuromuscular weakness lethargy Decreased

                                                                                                                                                                                          reflexes

                                                                                                                                                                                          Cardiovascular Hypotension arrest

                                                                                                                                                                                          ECG changes Increased PR interval

                                                                                                                                                                                          Widened QRS complex

                                                                                                                                                                                          Elevated T waves

                                                                                                                                                                                          Treatment

                                                                                                                                                                                          1 Withhold exogenous sources of magnesium

                                                                                                                                                                                          2 Correct volume deficit

                                                                                                                                                                                          3 Correct acidosis if present

                                                                                                                                                                                          4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                                          5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                                          عالئم

                                                                                                                                                                                          bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                                          meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                                          meqL

                                                                                                                                                                                          Hypomagnesemia

                                                                                                                                                                                          Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                                          homeostasis

                                                                                                                                                                                          Etiology

                                                                                                                                                                                          1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                                          inadequate supplementation of magnesium)

                                                                                                                                                                                          2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                                          3 GI losses (diarrhea)

                                                                                                                                                                                          4 Malabsorption

                                                                                                                                                                                          5 Acute pancreatitis

                                                                                                                                                                                          6 Diabetic ketoacidosis

                                                                                                                                                                                          7 Primary aldosteronism

                                                                                                                                                                                          Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                          1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                          2 Delirium and seizures in severe deficiency

                                                                                                                                                                                          3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                          ST-segment depression

                                                                                                                                                                                          Flattening or inversion of P waves

                                                                                                                                                                                          Torsades de pointes

                                                                                                                                                                                          Arrhythmia

                                                                                                                                                                                          Treatment

                                                                                                                                                                                          1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                          2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                          Message for Today

                                                                                                                                                                                          ICF

                                                                                                                                                                                          Interstitial

                                                                                                                                                                                          Pla

                                                                                                                                                                                          sma

                                                                                                                                                                                          5 Dex

                                                                                                                                                                                          bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                          • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                          • Slide 2
                                                                                                                                                                                          • Slide 3
                                                                                                                                                                                          • Slide 4
                                                                                                                                                                                          • Total Body Water
                                                                                                                                                                                          • Body Fluid Compartments
                                                                                                                                                                                          • Total body water (TBW)
                                                                                                                                                                                          • Body compartment fluid
                                                                                                                                                                                          • Example men with 70kg
                                                                                                                                                                                          • Fluid compartments
                                                                                                                                                                                          • Slide 11
                                                                                                                                                                                          • Slide 12
                                                                                                                                                                                          • Slide 13
                                                                                                                                                                                          • Slide 14
                                                                                                                                                                                          • Slide 15
                                                                                                                                                                                          • Colloid osmotic pressure
                                                                                                                                                                                          • Slide 17
                                                                                                                                                                                          • Slide 18
                                                                                                                                                                                          • Slide 19
                                                                                                                                                                                          • Cell Membrane
                                                                                                                                                                                          • Slide 21
                                                                                                                                                                                          • Slide 22
                                                                                                                                                                                          • Slide 23
                                                                                                                                                                                          • Slide 24
                                                                                                                                                                                          • Slide 25
                                                                                                                                                                                          • Composition of Fluid Compartments
                                                                                                                                                                                          • Composition of Body Fluids
                                                                                                                                                                                          • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                          • Reasons for fluid therapy
                                                                                                                                                                                          • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                          • محلولهای وریدی
                                                                                                                                                                                          • Fluids
                                                                                                                                                                                          • Slide 33
                                                                                                                                                                                          • Slide 34
                                                                                                                                                                                          • Slide 35
                                                                                                                                                                                          • Crystalloids
                                                                                                                                                                                          • Colloid Solutions
                                                                                                                                                                                          • رینگر لاکتات
                                                                                                                                                                                          • 09Nacl
                                                                                                                                                                                          • Postoperative (maintenance)
                                                                                                                                                                                          • Slide 41
                                                                                                                                                                                          • Preexisting fluid deficits
                                                                                                                                                                                          • Maintenance requirements
                                                                                                                                                                                          • Surgical fluid losses
                                                                                                                                                                                          • Third space loss
                                                                                                                                                                                          • Crystalloid solution
                                                                                                                                                                                          • Colloids
                                                                                                                                                                                          • Complications
                                                                                                                                                                                          • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                          • Colloid versus crystalloid solutions
                                                                                                                                                                                          • Transfusion consideration
                                                                                                                                                                                          • اختلال در حجم مایعات بدن
                                                                                                                                                                                          • Fluid volume deficit (FVD)
                                                                                                                                                                                          • DEHYDRATION
                                                                                                                                                                                          • علل کاهش حجم خارج سلولی
                                                                                                                                                                                          • Signs of Hypovolemia
                                                                                                                                                                                          • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                          • Signs of Hypervolemia
                                                                                                                                                                                          • Management of Hypervolemia
                                                                                                                                                                                          • Fluid Management
                                                                                                                                                                                          • Electrolyte physiology
                                                                                                                                                                                          • Sodium physiology
                                                                                                                                                                                          • Osmotic Pressure
                                                                                                                                                                                          • Concentration
                                                                                                                                                                                          • Hypernatremia
                                                                                                                                                                                          • - Hypernatremia
                                                                                                                                                                                          • Slide 67
                                                                                                                                                                                          • Slide 68
                                                                                                                                                                                          • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                          • Treatment
                                                                                                                                                                                          • Water deficit (L)= times TBW
                                                                                                                                                                                          • The rate of fluid administration
                                                                                                                                                                                          • Hyponatremia Nalt135mEqL
                                                                                                                                                                                          • Slide 74
                                                                                                                                                                                          • Sodium depletion
                                                                                                                                                                                          • Sodium dilution
                                                                                                                                                                                          • Sign and symptoms
                                                                                                                                                                                          • Slide 78
                                                                                                                                                                                          • Treatment
                                                                                                                                                                                          • Slide 80
                                                                                                                                                                                          • Slide 81
                                                                                                                                                                                          • Dose
                                                                                                                                                                                          • Potassium abnormalities
                                                                                                                                                                                          • Hyperkalemia
                                                                                                                                                                                          • Clinical manifestation of hyperkalemia
                                                                                                                                                                                          • Slide 86
                                                                                                                                                                                          • Slide 87
                                                                                                                                                                                          • Hypokalemia
                                                                                                                                                                                          • Potassium changes associated with alkalosis
                                                                                                                                                                                          • Slide 90
                                                                                                                                                                                          • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                          • Slide 92
                                                                                                                                                                                          • Calcium
                                                                                                                                                                                          • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                          • علائم هیپوکلسمی
                                                                                                                                                                                          • Slide 96
                                                                                                                                                                                          • Slide 97
                                                                                                                                                                                          • Slide 98
                                                                                                                                                                                          • Slide 99
                                                                                                                                                                                          • سایرعلائم
                                                                                                                                                                                          • درمان
                                                                                                                                                                                          • هيپركلسمي Cagt55meql
                                                                                                                                                                                          • علائم
                                                                                                                                                                                          • علائم قلبی
                                                                                                                                                                                          • Slide 105
                                                                                                                                                                                          • Magnesium Abnormalities
                                                                                                                                                                                          • منیزیوم
                                                                                                                                                                                          • Hypermagnesemia
                                                                                                                                                                                          • Clinical manifestation hypermanesemia
                                                                                                                                                                                          • Slide 110
                                                                                                                                                                                          • Slide 111
                                                                                                                                                                                          • Hypomagnesemia
                                                                                                                                                                                          • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                          • Slide 114
                                                                                                                                                                                          • Message for Today
                                                                                                                                                                                          • Slide 116

                                                                                                                                                                                            سایرعالئم

                                                                                                                                                                                            قلب bull انقباضي قدرت كاهشمركزي bull هاي وريد فشار افزايشخون bull فشار كاهشحنجره bull اسپاسماسكلتي bull عضالت اسپاسم

                                                                                                                                                                                            درمان

                                                                                                                                                                                            ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                                                            Cagt55meql هيپركلسمي

                                                                                                                                                                                            هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                                                            عالئم

                                                                                                                                                                                            bullGI

                                                                                                                                                                                            bullCardiovascular bullRenal (polyuria)

                                                                                                                                                                                            bullCNS

                                                                                                                                                                                            قلبی عالئم

                                                                                                                                                                                            bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                                                            QRS شدن )Q-Tوكوتاه

                                                                                                                                                                                            درمان

                                                                                                                                                                                            ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                                            الزیکس2

                                                                                                                                                                                            تونین 3 کلسی

                                                                                                                                                                                            کورتون4

                                                                                                                                                                                            دیالیز5

                                                                                                                                                                                            Magnesium Abnormalities

                                                                                                                                                                                            Normal dietary intake 20meq (240mg)

                                                                                                                                                                                            Excretion in both the feces and urine

                                                                                                                                                                                            Normal serum level 19-25 mgdL

                                                                                                                                                                                            منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                                            تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                                            bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                                            Hypermagnesemia

                                                                                                                                                                                            Etiology

                                                                                                                                                                                            1 Impaired renal function

                                                                                                                                                                                            2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                                            Clinical manifestation hypermanesemia

                                                                                                                                                                                            System hypermanesemia

                                                                                                                                                                                            Gastrointestinal Nauseavomiting

                                                                                                                                                                                            Neuromuscular weakness lethargy Decreased

                                                                                                                                                                                            reflexes

                                                                                                                                                                                            Cardiovascular Hypotension arrest

                                                                                                                                                                                            ECG changes Increased PR interval

                                                                                                                                                                                            Widened QRS complex

                                                                                                                                                                                            Elevated T waves

                                                                                                                                                                                            Treatment

                                                                                                                                                                                            1 Withhold exogenous sources of magnesium

                                                                                                                                                                                            2 Correct volume deficit

                                                                                                                                                                                            3 Correct acidosis if present

                                                                                                                                                                                            4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                                            5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                                            عالئم

                                                                                                                                                                                            bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                                            meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                                            meqL

                                                                                                                                                                                            Hypomagnesemia

                                                                                                                                                                                            Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                                            homeostasis

                                                                                                                                                                                            Etiology

                                                                                                                                                                                            1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                                            inadequate supplementation of magnesium)

                                                                                                                                                                                            2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                                            3 GI losses (diarrhea)

                                                                                                                                                                                            4 Malabsorption

                                                                                                                                                                                            5 Acute pancreatitis

                                                                                                                                                                                            6 Diabetic ketoacidosis

                                                                                                                                                                                            7 Primary aldosteronism

                                                                                                                                                                                            Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                            1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                            2 Delirium and seizures in severe deficiency

                                                                                                                                                                                            3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                            ST-segment depression

                                                                                                                                                                                            Flattening or inversion of P waves

                                                                                                                                                                                            Torsades de pointes

                                                                                                                                                                                            Arrhythmia

                                                                                                                                                                                            Treatment

                                                                                                                                                                                            1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                            2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                            Message for Today

                                                                                                                                                                                            ICF

                                                                                                                                                                                            Interstitial

                                                                                                                                                                                            Pla

                                                                                                                                                                                            sma

                                                                                                                                                                                            5 Dex

                                                                                                                                                                                            bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                            • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                            • Slide 2
                                                                                                                                                                                            • Slide 3
                                                                                                                                                                                            • Slide 4
                                                                                                                                                                                            • Total Body Water
                                                                                                                                                                                            • Body Fluid Compartments
                                                                                                                                                                                            • Total body water (TBW)
                                                                                                                                                                                            • Body compartment fluid
                                                                                                                                                                                            • Example men with 70kg
                                                                                                                                                                                            • Fluid compartments
                                                                                                                                                                                            • Slide 11
                                                                                                                                                                                            • Slide 12
                                                                                                                                                                                            • Slide 13
                                                                                                                                                                                            • Slide 14
                                                                                                                                                                                            • Slide 15
                                                                                                                                                                                            • Colloid osmotic pressure
                                                                                                                                                                                            • Slide 17
                                                                                                                                                                                            • Slide 18
                                                                                                                                                                                            • Slide 19
                                                                                                                                                                                            • Cell Membrane
                                                                                                                                                                                            • Slide 21
                                                                                                                                                                                            • Slide 22
                                                                                                                                                                                            • Slide 23
                                                                                                                                                                                            • Slide 24
                                                                                                                                                                                            • Slide 25
                                                                                                                                                                                            • Composition of Fluid Compartments
                                                                                                                                                                                            • Composition of Body Fluids
                                                                                                                                                                                            • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                            • Reasons for fluid therapy
                                                                                                                                                                                            • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                            • محلولهای وریدی
                                                                                                                                                                                            • Fluids
                                                                                                                                                                                            • Slide 33
                                                                                                                                                                                            • Slide 34
                                                                                                                                                                                            • Slide 35
                                                                                                                                                                                            • Crystalloids
                                                                                                                                                                                            • Colloid Solutions
                                                                                                                                                                                            • رینگر لاکتات
                                                                                                                                                                                            • 09Nacl
                                                                                                                                                                                            • Postoperative (maintenance)
                                                                                                                                                                                            • Slide 41
                                                                                                                                                                                            • Preexisting fluid deficits
                                                                                                                                                                                            • Maintenance requirements
                                                                                                                                                                                            • Surgical fluid losses
                                                                                                                                                                                            • Third space loss
                                                                                                                                                                                            • Crystalloid solution
                                                                                                                                                                                            • Colloids
                                                                                                                                                                                            • Complications
                                                                                                                                                                                            • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                            • Colloid versus crystalloid solutions
                                                                                                                                                                                            • Transfusion consideration
                                                                                                                                                                                            • اختلال در حجم مایعات بدن
                                                                                                                                                                                            • Fluid volume deficit (FVD)
                                                                                                                                                                                            • DEHYDRATION
                                                                                                                                                                                            • علل کاهش حجم خارج سلولی
                                                                                                                                                                                            • Signs of Hypovolemia
                                                                                                                                                                                            • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                            • Signs of Hypervolemia
                                                                                                                                                                                            • Management of Hypervolemia
                                                                                                                                                                                            • Fluid Management
                                                                                                                                                                                            • Electrolyte physiology
                                                                                                                                                                                            • Sodium physiology
                                                                                                                                                                                            • Osmotic Pressure
                                                                                                                                                                                            • Concentration
                                                                                                                                                                                            • Hypernatremia
                                                                                                                                                                                            • - Hypernatremia
                                                                                                                                                                                            • Slide 67
                                                                                                                                                                                            • Slide 68
                                                                                                                                                                                            • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                            • Treatment
                                                                                                                                                                                            • Water deficit (L)= times TBW
                                                                                                                                                                                            • The rate of fluid administration
                                                                                                                                                                                            • Hyponatremia Nalt135mEqL
                                                                                                                                                                                            • Slide 74
                                                                                                                                                                                            • Sodium depletion
                                                                                                                                                                                            • Sodium dilution
                                                                                                                                                                                            • Sign and symptoms
                                                                                                                                                                                            • Slide 78
                                                                                                                                                                                            • Treatment
                                                                                                                                                                                            • Slide 80
                                                                                                                                                                                            • Slide 81
                                                                                                                                                                                            • Dose
                                                                                                                                                                                            • Potassium abnormalities
                                                                                                                                                                                            • Hyperkalemia
                                                                                                                                                                                            • Clinical manifestation of hyperkalemia
                                                                                                                                                                                            • Slide 86
                                                                                                                                                                                            • Slide 87
                                                                                                                                                                                            • Hypokalemia
                                                                                                                                                                                            • Potassium changes associated with alkalosis
                                                                                                                                                                                            • Slide 90
                                                                                                                                                                                            • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                            • Slide 92
                                                                                                                                                                                            • Calcium
                                                                                                                                                                                            • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                            • علائم هیپوکلسمی
                                                                                                                                                                                            • Slide 96
                                                                                                                                                                                            • Slide 97
                                                                                                                                                                                            • Slide 98
                                                                                                                                                                                            • Slide 99
                                                                                                                                                                                            • سایرعلائم
                                                                                                                                                                                            • درمان
                                                                                                                                                                                            • هيپركلسمي Cagt55meql
                                                                                                                                                                                            • علائم
                                                                                                                                                                                            • علائم قلبی
                                                                                                                                                                                            • Slide 105
                                                                                                                                                                                            • Magnesium Abnormalities
                                                                                                                                                                                            • منیزیوم
                                                                                                                                                                                            • Hypermagnesemia
                                                                                                                                                                                            • Clinical manifestation hypermanesemia
                                                                                                                                                                                            • Slide 110
                                                                                                                                                                                            • Slide 111
                                                                                                                                                                                            • Hypomagnesemia
                                                                                                                                                                                            • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                            • Slide 114
                                                                                                                                                                                            • Message for Today
                                                                                                                                                                                            • Slide 116

                                                                                                                                                                                              درمان

                                                                                                                                                                                              ای bull زمینه علت کردن طرف بروریدی bull کلسیم

                                                                                                                                                                                              Cagt55meql هيپركلسمي

                                                                                                                                                                                              هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                                                              عالئم

                                                                                                                                                                                              bullGI

                                                                                                                                                                                              bullCardiovascular bullRenal (polyuria)

                                                                                                                                                                                              bullCNS

                                                                                                                                                                                              قلبی عالئم

                                                                                                                                                                                              bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                                                              QRS شدن )Q-Tوكوتاه

                                                                                                                                                                                              درمان

                                                                                                                                                                                              ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                                              الزیکس2

                                                                                                                                                                                              تونین 3 کلسی

                                                                                                                                                                                              کورتون4

                                                                                                                                                                                              دیالیز5

                                                                                                                                                                                              Magnesium Abnormalities

                                                                                                                                                                                              Normal dietary intake 20meq (240mg)

                                                                                                                                                                                              Excretion in both the feces and urine

                                                                                                                                                                                              Normal serum level 19-25 mgdL

                                                                                                                                                                                              منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                                              تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                                              bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                                              Hypermagnesemia

                                                                                                                                                                                              Etiology

                                                                                                                                                                                              1 Impaired renal function

                                                                                                                                                                                              2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                                              Clinical manifestation hypermanesemia

                                                                                                                                                                                              System hypermanesemia

                                                                                                                                                                                              Gastrointestinal Nauseavomiting

                                                                                                                                                                                              Neuromuscular weakness lethargy Decreased

                                                                                                                                                                                              reflexes

                                                                                                                                                                                              Cardiovascular Hypotension arrest

                                                                                                                                                                                              ECG changes Increased PR interval

                                                                                                                                                                                              Widened QRS complex

                                                                                                                                                                                              Elevated T waves

                                                                                                                                                                                              Treatment

                                                                                                                                                                                              1 Withhold exogenous sources of magnesium

                                                                                                                                                                                              2 Correct volume deficit

                                                                                                                                                                                              3 Correct acidosis if present

                                                                                                                                                                                              4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                                              5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                                              عالئم

                                                                                                                                                                                              bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                                              meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                                              meqL

                                                                                                                                                                                              Hypomagnesemia

                                                                                                                                                                                              Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                                              homeostasis

                                                                                                                                                                                              Etiology

                                                                                                                                                                                              1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                                              inadequate supplementation of magnesium)

                                                                                                                                                                                              2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                                              3 GI losses (diarrhea)

                                                                                                                                                                                              4 Malabsorption

                                                                                                                                                                                              5 Acute pancreatitis

                                                                                                                                                                                              6 Diabetic ketoacidosis

                                                                                                                                                                                              7 Primary aldosteronism

                                                                                                                                                                                              Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                              1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                              2 Delirium and seizures in severe deficiency

                                                                                                                                                                                              3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                              ST-segment depression

                                                                                                                                                                                              Flattening or inversion of P waves

                                                                                                                                                                                              Torsades de pointes

                                                                                                                                                                                              Arrhythmia

                                                                                                                                                                                              Treatment

                                                                                                                                                                                              1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                              2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                              Message for Today

                                                                                                                                                                                              ICF

                                                                                                                                                                                              Interstitial

                                                                                                                                                                                              Pla

                                                                                                                                                                                              sma

                                                                                                                                                                                              5 Dex

                                                                                                                                                                                              bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                              • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                              • Slide 2
                                                                                                                                                                                              • Slide 3
                                                                                                                                                                                              • Slide 4
                                                                                                                                                                                              • Total Body Water
                                                                                                                                                                                              • Body Fluid Compartments
                                                                                                                                                                                              • Total body water (TBW)
                                                                                                                                                                                              • Body compartment fluid
                                                                                                                                                                                              • Example men with 70kg
                                                                                                                                                                                              • Fluid compartments
                                                                                                                                                                                              • Slide 11
                                                                                                                                                                                              • Slide 12
                                                                                                                                                                                              • Slide 13
                                                                                                                                                                                              • Slide 14
                                                                                                                                                                                              • Slide 15
                                                                                                                                                                                              • Colloid osmotic pressure
                                                                                                                                                                                              • Slide 17
                                                                                                                                                                                              • Slide 18
                                                                                                                                                                                              • Slide 19
                                                                                                                                                                                              • Cell Membrane
                                                                                                                                                                                              • Slide 21
                                                                                                                                                                                              • Slide 22
                                                                                                                                                                                              • Slide 23
                                                                                                                                                                                              • Slide 24
                                                                                                                                                                                              • Slide 25
                                                                                                                                                                                              • Composition of Fluid Compartments
                                                                                                                                                                                              • Composition of Body Fluids
                                                                                                                                                                                              • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                              • Reasons for fluid therapy
                                                                                                                                                                                              • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                              • محلولهای وریدی
                                                                                                                                                                                              • Fluids
                                                                                                                                                                                              • Slide 33
                                                                                                                                                                                              • Slide 34
                                                                                                                                                                                              • Slide 35
                                                                                                                                                                                              • Crystalloids
                                                                                                                                                                                              • Colloid Solutions
                                                                                                                                                                                              • رینگر لاکتات
                                                                                                                                                                                              • 09Nacl
                                                                                                                                                                                              • Postoperative (maintenance)
                                                                                                                                                                                              • Slide 41
                                                                                                                                                                                              • Preexisting fluid deficits
                                                                                                                                                                                              • Maintenance requirements
                                                                                                                                                                                              • Surgical fluid losses
                                                                                                                                                                                              • Third space loss
                                                                                                                                                                                              • Crystalloid solution
                                                                                                                                                                                              • Colloids
                                                                                                                                                                                              • Complications
                                                                                                                                                                                              • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                              • Colloid versus crystalloid solutions
                                                                                                                                                                                              • Transfusion consideration
                                                                                                                                                                                              • اختلال در حجم مایعات بدن
                                                                                                                                                                                              • Fluid volume deficit (FVD)
                                                                                                                                                                                              • DEHYDRATION
                                                                                                                                                                                              • علل کاهش حجم خارج سلولی
                                                                                                                                                                                              • Signs of Hypovolemia
                                                                                                                                                                                              • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                              • Signs of Hypervolemia
                                                                                                                                                                                              • Management of Hypervolemia
                                                                                                                                                                                              • Fluid Management
                                                                                                                                                                                              • Electrolyte physiology
                                                                                                                                                                                              • Sodium physiology
                                                                                                                                                                                              • Osmotic Pressure
                                                                                                                                                                                              • Concentration
                                                                                                                                                                                              • Hypernatremia
                                                                                                                                                                                              • - Hypernatremia
                                                                                                                                                                                              • Slide 67
                                                                                                                                                                                              • Slide 68
                                                                                                                                                                                              • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                              • Treatment
                                                                                                                                                                                              • Water deficit (L)= times TBW
                                                                                                                                                                                              • The rate of fluid administration
                                                                                                                                                                                              • Hyponatremia Nalt135mEqL
                                                                                                                                                                                              • Slide 74
                                                                                                                                                                                              • Sodium depletion
                                                                                                                                                                                              • Sodium dilution
                                                                                                                                                                                              • Sign and symptoms
                                                                                                                                                                                              • Slide 78
                                                                                                                                                                                              • Treatment
                                                                                                                                                                                              • Slide 80
                                                                                                                                                                                              • Slide 81
                                                                                                                                                                                              • Dose
                                                                                                                                                                                              • Potassium abnormalities
                                                                                                                                                                                              • Hyperkalemia
                                                                                                                                                                                              • Clinical manifestation of hyperkalemia
                                                                                                                                                                                              • Slide 86
                                                                                                                                                                                              • Slide 87
                                                                                                                                                                                              • Hypokalemia
                                                                                                                                                                                              • Potassium changes associated with alkalosis
                                                                                                                                                                                              • Slide 90
                                                                                                                                                                                              • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                              • Slide 92
                                                                                                                                                                                              • Calcium
                                                                                                                                                                                              • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                              • علائم هیپوکلسمی
                                                                                                                                                                                              • Slide 96
                                                                                                                                                                                              • Slide 97
                                                                                                                                                                                              • Slide 98
                                                                                                                                                                                              • Slide 99
                                                                                                                                                                                              • سایرعلائم
                                                                                                                                                                                              • درمان
                                                                                                                                                                                              • هيپركلسمي Cagt55meql
                                                                                                                                                                                              • علائم
                                                                                                                                                                                              • علائم قلبی
                                                                                                                                                                                              • Slide 105
                                                                                                                                                                                              • Magnesium Abnormalities
                                                                                                                                                                                              • منیزیوم
                                                                                                                                                                                              • Hypermagnesemia
                                                                                                                                                                                              • Clinical manifestation hypermanesemia
                                                                                                                                                                                              • Slide 110
                                                                                                                                                                                              • Slide 111
                                                                                                                                                                                              • Hypomagnesemia
                                                                                                                                                                                              • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                              • Slide 114
                                                                                                                                                                                              • Message for Today
                                                                                                                                                                                              • Slide 116

                                                                                                                                                                                                Cagt55meql هيپركلسمي

                                                                                                                                                                                                هيپرپاراتيروئيديسمbullاستخواني bull متاستاز با كانسرهامدت bull طوالنی حرکتی بیدیورتیک ( ndash )bull لیتیوم داروها

                                                                                                                                                                                                عالئم

                                                                                                                                                                                                bullGI

                                                                                                                                                                                                bullCardiovascular bullRenal (polyuria)

                                                                                                                                                                                                bullCNS

                                                                                                                                                                                                قلبی عالئم

                                                                                                                                                                                                bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                                                                QRS شدن )Q-Tوكوتاه

                                                                                                                                                                                                درمان

                                                                                                                                                                                                ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                                                الزیکس2

                                                                                                                                                                                                تونین 3 کلسی

                                                                                                                                                                                                کورتون4

                                                                                                                                                                                                دیالیز5

                                                                                                                                                                                                Magnesium Abnormalities

                                                                                                                                                                                                Normal dietary intake 20meq (240mg)

                                                                                                                                                                                                Excretion in both the feces and urine

                                                                                                                                                                                                Normal serum level 19-25 mgdL

                                                                                                                                                                                                منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                                                تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                                                bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                                                Hypermagnesemia

                                                                                                                                                                                                Etiology

                                                                                                                                                                                                1 Impaired renal function

                                                                                                                                                                                                2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                                                Clinical manifestation hypermanesemia

                                                                                                                                                                                                System hypermanesemia

                                                                                                                                                                                                Gastrointestinal Nauseavomiting

                                                                                                                                                                                                Neuromuscular weakness lethargy Decreased

                                                                                                                                                                                                reflexes

                                                                                                                                                                                                Cardiovascular Hypotension arrest

                                                                                                                                                                                                ECG changes Increased PR interval

                                                                                                                                                                                                Widened QRS complex

                                                                                                                                                                                                Elevated T waves

                                                                                                                                                                                                Treatment

                                                                                                                                                                                                1 Withhold exogenous sources of magnesium

                                                                                                                                                                                                2 Correct volume deficit

                                                                                                                                                                                                3 Correct acidosis if present

                                                                                                                                                                                                4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                                                5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                                                عالئم

                                                                                                                                                                                                bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                                                meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                                                meqL

                                                                                                                                                                                                Hypomagnesemia

                                                                                                                                                                                                Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                                                homeostasis

                                                                                                                                                                                                Etiology

                                                                                                                                                                                                1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                                                inadequate supplementation of magnesium)

                                                                                                                                                                                                2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                                                3 GI losses (diarrhea)

                                                                                                                                                                                                4 Malabsorption

                                                                                                                                                                                                5 Acute pancreatitis

                                                                                                                                                                                                6 Diabetic ketoacidosis

                                                                                                                                                                                                7 Primary aldosteronism

                                                                                                                                                                                                Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                                1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                                2 Delirium and seizures in severe deficiency

                                                                                                                                                                                                3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                                ST-segment depression

                                                                                                                                                                                                Flattening or inversion of P waves

                                                                                                                                                                                                Torsades de pointes

                                                                                                                                                                                                Arrhythmia

                                                                                                                                                                                                Treatment

                                                                                                                                                                                                1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                                2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                                Message for Today

                                                                                                                                                                                                ICF

                                                                                                                                                                                                Interstitial

                                                                                                                                                                                                Pla

                                                                                                                                                                                                sma

                                                                                                                                                                                                5 Dex

                                                                                                                                                                                                bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                                • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                                • Slide 2
                                                                                                                                                                                                • Slide 3
                                                                                                                                                                                                • Slide 4
                                                                                                                                                                                                • Total Body Water
                                                                                                                                                                                                • Body Fluid Compartments
                                                                                                                                                                                                • Total body water (TBW)
                                                                                                                                                                                                • Body compartment fluid
                                                                                                                                                                                                • Example men with 70kg
                                                                                                                                                                                                • Fluid compartments
                                                                                                                                                                                                • Slide 11
                                                                                                                                                                                                • Slide 12
                                                                                                                                                                                                • Slide 13
                                                                                                                                                                                                • Slide 14
                                                                                                                                                                                                • Slide 15
                                                                                                                                                                                                • Colloid osmotic pressure
                                                                                                                                                                                                • Slide 17
                                                                                                                                                                                                • Slide 18
                                                                                                                                                                                                • Slide 19
                                                                                                                                                                                                • Cell Membrane
                                                                                                                                                                                                • Slide 21
                                                                                                                                                                                                • Slide 22
                                                                                                                                                                                                • Slide 23
                                                                                                                                                                                                • Slide 24
                                                                                                                                                                                                • Slide 25
                                                                                                                                                                                                • Composition of Fluid Compartments
                                                                                                                                                                                                • Composition of Body Fluids
                                                                                                                                                                                                • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                                • Reasons for fluid therapy
                                                                                                                                                                                                • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                                • محلولهای وریدی
                                                                                                                                                                                                • Fluids
                                                                                                                                                                                                • Slide 33
                                                                                                                                                                                                • Slide 34
                                                                                                                                                                                                • Slide 35
                                                                                                                                                                                                • Crystalloids
                                                                                                                                                                                                • Colloid Solutions
                                                                                                                                                                                                • رینگر لاکتات
                                                                                                                                                                                                • 09Nacl
                                                                                                                                                                                                • Postoperative (maintenance)
                                                                                                                                                                                                • Slide 41
                                                                                                                                                                                                • Preexisting fluid deficits
                                                                                                                                                                                                • Maintenance requirements
                                                                                                                                                                                                • Surgical fluid losses
                                                                                                                                                                                                • Third space loss
                                                                                                                                                                                                • Crystalloid solution
                                                                                                                                                                                                • Colloids
                                                                                                                                                                                                • Complications
                                                                                                                                                                                                • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                                • Colloid versus crystalloid solutions
                                                                                                                                                                                                • Transfusion consideration
                                                                                                                                                                                                • اختلال در حجم مایعات بدن
                                                                                                                                                                                                • Fluid volume deficit (FVD)
                                                                                                                                                                                                • DEHYDRATION
                                                                                                                                                                                                • علل کاهش حجم خارج سلولی
                                                                                                                                                                                                • Signs of Hypovolemia
                                                                                                                                                                                                • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                                • Signs of Hypervolemia
                                                                                                                                                                                                • Management of Hypervolemia
                                                                                                                                                                                                • Fluid Management
                                                                                                                                                                                                • Electrolyte physiology
                                                                                                                                                                                                • Sodium physiology
                                                                                                                                                                                                • Osmotic Pressure
                                                                                                                                                                                                • Concentration
                                                                                                                                                                                                • Hypernatremia
                                                                                                                                                                                                • - Hypernatremia
                                                                                                                                                                                                • Slide 67
                                                                                                                                                                                                • Slide 68
                                                                                                                                                                                                • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                                • Treatment
                                                                                                                                                                                                • Water deficit (L)= times TBW
                                                                                                                                                                                                • The rate of fluid administration
                                                                                                                                                                                                • Hyponatremia Nalt135mEqL
                                                                                                                                                                                                • Slide 74
                                                                                                                                                                                                • Sodium depletion
                                                                                                                                                                                                • Sodium dilution
                                                                                                                                                                                                • Sign and symptoms
                                                                                                                                                                                                • Slide 78
                                                                                                                                                                                                • Treatment
                                                                                                                                                                                                • Slide 80
                                                                                                                                                                                                • Slide 81
                                                                                                                                                                                                • Dose
                                                                                                                                                                                                • Potassium abnormalities
                                                                                                                                                                                                • Hyperkalemia
                                                                                                                                                                                                • Clinical manifestation of hyperkalemia
                                                                                                                                                                                                • Slide 86
                                                                                                                                                                                                • Slide 87
                                                                                                                                                                                                • Hypokalemia
                                                                                                                                                                                                • Potassium changes associated with alkalosis
                                                                                                                                                                                                • Slide 90
                                                                                                                                                                                                • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                                • Slide 92
                                                                                                                                                                                                • Calcium
                                                                                                                                                                                                • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                                • علائم هیپوکلسمی
                                                                                                                                                                                                • Slide 96
                                                                                                                                                                                                • Slide 97
                                                                                                                                                                                                • Slide 98
                                                                                                                                                                                                • Slide 99
                                                                                                                                                                                                • سایرعلائم
                                                                                                                                                                                                • درمان
                                                                                                                                                                                                • هيپركلسمي Cagt55meql
                                                                                                                                                                                                • علائم
                                                                                                                                                                                                • علائم قلبی
                                                                                                                                                                                                • Slide 105
                                                                                                                                                                                                • Magnesium Abnormalities
                                                                                                                                                                                                • منیزیوم
                                                                                                                                                                                                • Hypermagnesemia
                                                                                                                                                                                                • Clinical manifestation hypermanesemia
                                                                                                                                                                                                • Slide 110
                                                                                                                                                                                                • Slide 111
                                                                                                                                                                                                • Hypomagnesemia
                                                                                                                                                                                                • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                                • Slide 114
                                                                                                                                                                                                • Message for Today
                                                                                                                                                                                                • Slide 116

                                                                                                                                                                                                  عالئم

                                                                                                                                                                                                  bullGI

                                                                                                                                                                                                  bullCardiovascular bullRenal (polyuria)

                                                                                                                                                                                                  bullCNS

                                                                                                                                                                                                  قلبی عالئم

                                                                                                                                                                                                  bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                                                                  QRS شدن )Q-Tوكوتاه

                                                                                                                                                                                                  درمان

                                                                                                                                                                                                  ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                                                  الزیکس2

                                                                                                                                                                                                  تونین 3 کلسی

                                                                                                                                                                                                  کورتون4

                                                                                                                                                                                                  دیالیز5

                                                                                                                                                                                                  Magnesium Abnormalities

                                                                                                                                                                                                  Normal dietary intake 20meq (240mg)

                                                                                                                                                                                                  Excretion in both the feces and urine

                                                                                                                                                                                                  Normal serum level 19-25 mgdL

                                                                                                                                                                                                  منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                                                  تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                                                  bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                                                  Hypermagnesemia

                                                                                                                                                                                                  Etiology

                                                                                                                                                                                                  1 Impaired renal function

                                                                                                                                                                                                  2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                                                  Clinical manifestation hypermanesemia

                                                                                                                                                                                                  System hypermanesemia

                                                                                                                                                                                                  Gastrointestinal Nauseavomiting

                                                                                                                                                                                                  Neuromuscular weakness lethargy Decreased

                                                                                                                                                                                                  reflexes

                                                                                                                                                                                                  Cardiovascular Hypotension arrest

                                                                                                                                                                                                  ECG changes Increased PR interval

                                                                                                                                                                                                  Widened QRS complex

                                                                                                                                                                                                  Elevated T waves

                                                                                                                                                                                                  Treatment

                                                                                                                                                                                                  1 Withhold exogenous sources of magnesium

                                                                                                                                                                                                  2 Correct volume deficit

                                                                                                                                                                                                  3 Correct acidosis if present

                                                                                                                                                                                                  4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                                                  5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                                                  عالئم

                                                                                                                                                                                                  bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                                                  meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                                                  meqL

                                                                                                                                                                                                  Hypomagnesemia

                                                                                                                                                                                                  Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                                                  homeostasis

                                                                                                                                                                                                  Etiology

                                                                                                                                                                                                  1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                                                  inadequate supplementation of magnesium)

                                                                                                                                                                                                  2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                                                  3 GI losses (diarrhea)

                                                                                                                                                                                                  4 Malabsorption

                                                                                                                                                                                                  5 Acute pancreatitis

                                                                                                                                                                                                  6 Diabetic ketoacidosis

                                                                                                                                                                                                  7 Primary aldosteronism

                                                                                                                                                                                                  Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                                  1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                                  2 Delirium and seizures in severe deficiency

                                                                                                                                                                                                  3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                                  ST-segment depression

                                                                                                                                                                                                  Flattening or inversion of P waves

                                                                                                                                                                                                  Torsades de pointes

                                                                                                                                                                                                  Arrhythmia

                                                                                                                                                                                                  Treatment

                                                                                                                                                                                                  1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                                  2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                                  Message for Today

                                                                                                                                                                                                  ICF

                                                                                                                                                                                                  Interstitial

                                                                                                                                                                                                  Pla

                                                                                                                                                                                                  sma

                                                                                                                                                                                                  5 Dex

                                                                                                                                                                                                  bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                                  • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                                  • Slide 2
                                                                                                                                                                                                  • Slide 3
                                                                                                                                                                                                  • Slide 4
                                                                                                                                                                                                  • Total Body Water
                                                                                                                                                                                                  • Body Fluid Compartments
                                                                                                                                                                                                  • Total body water (TBW)
                                                                                                                                                                                                  • Body compartment fluid
                                                                                                                                                                                                  • Example men with 70kg
                                                                                                                                                                                                  • Fluid compartments
                                                                                                                                                                                                  • Slide 11
                                                                                                                                                                                                  • Slide 12
                                                                                                                                                                                                  • Slide 13
                                                                                                                                                                                                  • Slide 14
                                                                                                                                                                                                  • Slide 15
                                                                                                                                                                                                  • Colloid osmotic pressure
                                                                                                                                                                                                  • Slide 17
                                                                                                                                                                                                  • Slide 18
                                                                                                                                                                                                  • Slide 19
                                                                                                                                                                                                  • Cell Membrane
                                                                                                                                                                                                  • Slide 21
                                                                                                                                                                                                  • Slide 22
                                                                                                                                                                                                  • Slide 23
                                                                                                                                                                                                  • Slide 24
                                                                                                                                                                                                  • Slide 25
                                                                                                                                                                                                  • Composition of Fluid Compartments
                                                                                                                                                                                                  • Composition of Body Fluids
                                                                                                                                                                                                  • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                                  • Reasons for fluid therapy
                                                                                                                                                                                                  • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                                  • محلولهای وریدی
                                                                                                                                                                                                  • Fluids
                                                                                                                                                                                                  • Slide 33
                                                                                                                                                                                                  • Slide 34
                                                                                                                                                                                                  • Slide 35
                                                                                                                                                                                                  • Crystalloids
                                                                                                                                                                                                  • Colloid Solutions
                                                                                                                                                                                                  • رینگر لاکتات
                                                                                                                                                                                                  • 09Nacl
                                                                                                                                                                                                  • Postoperative (maintenance)
                                                                                                                                                                                                  • Slide 41
                                                                                                                                                                                                  • Preexisting fluid deficits
                                                                                                                                                                                                  • Maintenance requirements
                                                                                                                                                                                                  • Surgical fluid losses
                                                                                                                                                                                                  • Third space loss
                                                                                                                                                                                                  • Crystalloid solution
                                                                                                                                                                                                  • Colloids
                                                                                                                                                                                                  • Complications
                                                                                                                                                                                                  • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                                  • Colloid versus crystalloid solutions
                                                                                                                                                                                                  • Transfusion consideration
                                                                                                                                                                                                  • اختلال در حجم مایعات بدن
                                                                                                                                                                                                  • Fluid volume deficit (FVD)
                                                                                                                                                                                                  • DEHYDRATION
                                                                                                                                                                                                  • علل کاهش حجم خارج سلولی
                                                                                                                                                                                                  • Signs of Hypovolemia
                                                                                                                                                                                                  • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                                  • Signs of Hypervolemia
                                                                                                                                                                                                  • Management of Hypervolemia
                                                                                                                                                                                                  • Fluid Management
                                                                                                                                                                                                  • Electrolyte physiology
                                                                                                                                                                                                  • Sodium physiology
                                                                                                                                                                                                  • Osmotic Pressure
                                                                                                                                                                                                  • Concentration
                                                                                                                                                                                                  • Hypernatremia
                                                                                                                                                                                                  • - Hypernatremia
                                                                                                                                                                                                  • Slide 67
                                                                                                                                                                                                  • Slide 68
                                                                                                                                                                                                  • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                                  • Treatment
                                                                                                                                                                                                  • Water deficit (L)= times TBW
                                                                                                                                                                                                  • The rate of fluid administration
                                                                                                                                                                                                  • Hyponatremia Nalt135mEqL
                                                                                                                                                                                                  • Slide 74
                                                                                                                                                                                                  • Sodium depletion
                                                                                                                                                                                                  • Sodium dilution
                                                                                                                                                                                                  • Sign and symptoms
                                                                                                                                                                                                  • Slide 78
                                                                                                                                                                                                  • Treatment
                                                                                                                                                                                                  • Slide 80
                                                                                                                                                                                                  • Slide 81
                                                                                                                                                                                                  • Dose
                                                                                                                                                                                                  • Potassium abnormalities
                                                                                                                                                                                                  • Hyperkalemia
                                                                                                                                                                                                  • Clinical manifestation of hyperkalemia
                                                                                                                                                                                                  • Slide 86
                                                                                                                                                                                                  • Slide 87
                                                                                                                                                                                                  • Hypokalemia
                                                                                                                                                                                                  • Potassium changes associated with alkalosis
                                                                                                                                                                                                  • Slide 90
                                                                                                                                                                                                  • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                                  • Slide 92
                                                                                                                                                                                                  • Calcium
                                                                                                                                                                                                  • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                                  • علائم هیپوکلسمی
                                                                                                                                                                                                  • Slide 96
                                                                                                                                                                                                  • Slide 97
                                                                                                                                                                                                  • Slide 98
                                                                                                                                                                                                  • Slide 99
                                                                                                                                                                                                  • سایرعلائم
                                                                                                                                                                                                  • درمان
                                                                                                                                                                                                  • هيپركلسمي Cagt55meql
                                                                                                                                                                                                  • علائم
                                                                                                                                                                                                  • علائم قلبی
                                                                                                                                                                                                  • Slide 105
                                                                                                                                                                                                  • Magnesium Abnormalities
                                                                                                                                                                                                  • منیزیوم
                                                                                                                                                                                                  • Hypermagnesemia
                                                                                                                                                                                                  • Clinical manifestation hypermanesemia
                                                                                                                                                                                                  • Slide 110
                                                                                                                                                                                                  • Slide 111
                                                                                                                                                                                                  • Hypomagnesemia
                                                                                                                                                                                                  • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                                  • Slide 114
                                                                                                                                                                                                  • Message for Today
                                                                                                                                                                                                  • Slide 116

                                                                                                                                                                                                    قلبی عالئم

                                                                                                                                                                                                    bull Cagt7 meqlفاصله ( افزايش قلبي هدايت شدن P-Rاختالالت پهن

                                                                                                                                                                                                    QRS شدن )Q-Tوكوتاه

                                                                                                                                                                                                    درمان

                                                                                                                                                                                                    ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                                                    الزیکس2

                                                                                                                                                                                                    تونین 3 کلسی

                                                                                                                                                                                                    کورتون4

                                                                                                                                                                                                    دیالیز5

                                                                                                                                                                                                    Magnesium Abnormalities

                                                                                                                                                                                                    Normal dietary intake 20meq (240mg)

                                                                                                                                                                                                    Excretion in both the feces and urine

                                                                                                                                                                                                    Normal serum level 19-25 mgdL

                                                                                                                                                                                                    منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                                                    تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                                                    bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                                                    Hypermagnesemia

                                                                                                                                                                                                    Etiology

                                                                                                                                                                                                    1 Impaired renal function

                                                                                                                                                                                                    2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                                                    Clinical manifestation hypermanesemia

                                                                                                                                                                                                    System hypermanesemia

                                                                                                                                                                                                    Gastrointestinal Nauseavomiting

                                                                                                                                                                                                    Neuromuscular weakness lethargy Decreased

                                                                                                                                                                                                    reflexes

                                                                                                                                                                                                    Cardiovascular Hypotension arrest

                                                                                                                                                                                                    ECG changes Increased PR interval

                                                                                                                                                                                                    Widened QRS complex

                                                                                                                                                                                                    Elevated T waves

                                                                                                                                                                                                    Treatment

                                                                                                                                                                                                    1 Withhold exogenous sources of magnesium

                                                                                                                                                                                                    2 Correct volume deficit

                                                                                                                                                                                                    3 Correct acidosis if present

                                                                                                                                                                                                    4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                                                    5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                                                    عالئم

                                                                                                                                                                                                    bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                                                    meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                                                    meqL

                                                                                                                                                                                                    Hypomagnesemia

                                                                                                                                                                                                    Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                                                    homeostasis

                                                                                                                                                                                                    Etiology

                                                                                                                                                                                                    1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                                                    inadequate supplementation of magnesium)

                                                                                                                                                                                                    2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                                                    3 GI losses (diarrhea)

                                                                                                                                                                                                    4 Malabsorption

                                                                                                                                                                                                    5 Acute pancreatitis

                                                                                                                                                                                                    6 Diabetic ketoacidosis

                                                                                                                                                                                                    7 Primary aldosteronism

                                                                                                                                                                                                    Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                                    1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                                    2 Delirium and seizures in severe deficiency

                                                                                                                                                                                                    3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                                    ST-segment depression

                                                                                                                                                                                                    Flattening or inversion of P waves

                                                                                                                                                                                                    Torsades de pointes

                                                                                                                                                                                                    Arrhythmia

                                                                                                                                                                                                    Treatment

                                                                                                                                                                                                    1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                                    2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                                    Message for Today

                                                                                                                                                                                                    ICF

                                                                                                                                                                                                    Interstitial

                                                                                                                                                                                                    Pla

                                                                                                                                                                                                    sma

                                                                                                                                                                                                    5 Dex

                                                                                                                                                                                                    bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                                    • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                                    • Slide 2
                                                                                                                                                                                                    • Slide 3
                                                                                                                                                                                                    • Slide 4
                                                                                                                                                                                                    • Total Body Water
                                                                                                                                                                                                    • Body Fluid Compartments
                                                                                                                                                                                                    • Total body water (TBW)
                                                                                                                                                                                                    • Body compartment fluid
                                                                                                                                                                                                    • Example men with 70kg
                                                                                                                                                                                                    • Fluid compartments
                                                                                                                                                                                                    • Slide 11
                                                                                                                                                                                                    • Slide 12
                                                                                                                                                                                                    • Slide 13
                                                                                                                                                                                                    • Slide 14
                                                                                                                                                                                                    • Slide 15
                                                                                                                                                                                                    • Colloid osmotic pressure
                                                                                                                                                                                                    • Slide 17
                                                                                                                                                                                                    • Slide 18
                                                                                                                                                                                                    • Slide 19
                                                                                                                                                                                                    • Cell Membrane
                                                                                                                                                                                                    • Slide 21
                                                                                                                                                                                                    • Slide 22
                                                                                                                                                                                                    • Slide 23
                                                                                                                                                                                                    • Slide 24
                                                                                                                                                                                                    • Slide 25
                                                                                                                                                                                                    • Composition of Fluid Compartments
                                                                                                                                                                                                    • Composition of Body Fluids
                                                                                                                                                                                                    • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                                    • Reasons for fluid therapy
                                                                                                                                                                                                    • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                                    • محلولهای وریدی
                                                                                                                                                                                                    • Fluids
                                                                                                                                                                                                    • Slide 33
                                                                                                                                                                                                    • Slide 34
                                                                                                                                                                                                    • Slide 35
                                                                                                                                                                                                    • Crystalloids
                                                                                                                                                                                                    • Colloid Solutions
                                                                                                                                                                                                    • رینگر لاکتات
                                                                                                                                                                                                    • 09Nacl
                                                                                                                                                                                                    • Postoperative (maintenance)
                                                                                                                                                                                                    • Slide 41
                                                                                                                                                                                                    • Preexisting fluid deficits
                                                                                                                                                                                                    • Maintenance requirements
                                                                                                                                                                                                    • Surgical fluid losses
                                                                                                                                                                                                    • Third space loss
                                                                                                                                                                                                    • Crystalloid solution
                                                                                                                                                                                                    • Colloids
                                                                                                                                                                                                    • Complications
                                                                                                                                                                                                    • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                                    • Colloid versus crystalloid solutions
                                                                                                                                                                                                    • Transfusion consideration
                                                                                                                                                                                                    • اختلال در حجم مایعات بدن
                                                                                                                                                                                                    • Fluid volume deficit (FVD)
                                                                                                                                                                                                    • DEHYDRATION
                                                                                                                                                                                                    • علل کاهش حجم خارج سلولی
                                                                                                                                                                                                    • Signs of Hypovolemia
                                                                                                                                                                                                    • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                                    • Signs of Hypervolemia
                                                                                                                                                                                                    • Management of Hypervolemia
                                                                                                                                                                                                    • Fluid Management
                                                                                                                                                                                                    • Electrolyte physiology
                                                                                                                                                                                                    • Sodium physiology
                                                                                                                                                                                                    • Osmotic Pressure
                                                                                                                                                                                                    • Concentration
                                                                                                                                                                                                    • Hypernatremia
                                                                                                                                                                                                    • - Hypernatremia
                                                                                                                                                                                                    • Slide 67
                                                                                                                                                                                                    • Slide 68
                                                                                                                                                                                                    • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                                    • Treatment
                                                                                                                                                                                                    • Water deficit (L)= times TBW
                                                                                                                                                                                                    • The rate of fluid administration
                                                                                                                                                                                                    • Hyponatremia Nalt135mEqL
                                                                                                                                                                                                    • Slide 74
                                                                                                                                                                                                    • Sodium depletion
                                                                                                                                                                                                    • Sodium dilution
                                                                                                                                                                                                    • Sign and symptoms
                                                                                                                                                                                                    • Slide 78
                                                                                                                                                                                                    • Treatment
                                                                                                                                                                                                    • Slide 80
                                                                                                                                                                                                    • Slide 81
                                                                                                                                                                                                    • Dose
                                                                                                                                                                                                    • Potassium abnormalities
                                                                                                                                                                                                    • Hyperkalemia
                                                                                                                                                                                                    • Clinical manifestation of hyperkalemia
                                                                                                                                                                                                    • Slide 86
                                                                                                                                                                                                    • Slide 87
                                                                                                                                                                                                    • Hypokalemia
                                                                                                                                                                                                    • Potassium changes associated with alkalosis
                                                                                                                                                                                                    • Slide 90
                                                                                                                                                                                                    • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                                    • Slide 92
                                                                                                                                                                                                    • Calcium
                                                                                                                                                                                                    • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                                    • علائم هیپوکلسمی
                                                                                                                                                                                                    • Slide 96
                                                                                                                                                                                                    • Slide 97
                                                                                                                                                                                                    • Slide 98
                                                                                                                                                                                                    • Slide 99
                                                                                                                                                                                                    • سایرعلائم
                                                                                                                                                                                                    • درمان
                                                                                                                                                                                                    • هيپركلسمي Cagt55meql
                                                                                                                                                                                                    • علائم
                                                                                                                                                                                                    • علائم قلبی
                                                                                                                                                                                                    • Slide 105
                                                                                                                                                                                                    • Magnesium Abnormalities
                                                                                                                                                                                                    • منیزیوم
                                                                                                                                                                                                    • Hypermagnesemia
                                                                                                                                                                                                    • Clinical manifestation hypermanesemia
                                                                                                                                                                                                    • Slide 110
                                                                                                                                                                                                    • Slide 111
                                                                                                                                                                                                    • Hypomagnesemia
                                                                                                                                                                                                    • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                                    • Slide 114
                                                                                                                                                                                                    • Message for Today
                                                                                                                                                                                                    • Slide 116

                                                                                                                                                                                                      درمان

                                                                                                                                                                                                      ایزوتونیک 1 نمکی محلول انفوزیون

                                                                                                                                                                                                      الزیکس2

                                                                                                                                                                                                      تونین 3 کلسی

                                                                                                                                                                                                      کورتون4

                                                                                                                                                                                                      دیالیز5

                                                                                                                                                                                                      Magnesium Abnormalities

                                                                                                                                                                                                      Normal dietary intake 20meq (240mg)

                                                                                                                                                                                                      Excretion in both the feces and urine

                                                                                                                                                                                                      Normal serum level 19-25 mgdL

                                                                                                                                                                                                      منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                                                      تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                                                      bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                                                      Hypermagnesemia

                                                                                                                                                                                                      Etiology

                                                                                                                                                                                                      1 Impaired renal function

                                                                                                                                                                                                      2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                                                      Clinical manifestation hypermanesemia

                                                                                                                                                                                                      System hypermanesemia

                                                                                                                                                                                                      Gastrointestinal Nauseavomiting

                                                                                                                                                                                                      Neuromuscular weakness lethargy Decreased

                                                                                                                                                                                                      reflexes

                                                                                                                                                                                                      Cardiovascular Hypotension arrest

                                                                                                                                                                                                      ECG changes Increased PR interval

                                                                                                                                                                                                      Widened QRS complex

                                                                                                                                                                                                      Elevated T waves

                                                                                                                                                                                                      Treatment

                                                                                                                                                                                                      1 Withhold exogenous sources of magnesium

                                                                                                                                                                                                      2 Correct volume deficit

                                                                                                                                                                                                      3 Correct acidosis if present

                                                                                                                                                                                                      4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                                                      5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                                                      عالئم

                                                                                                                                                                                                      bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                                                      meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                                                      meqL

                                                                                                                                                                                                      Hypomagnesemia

                                                                                                                                                                                                      Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                                                      homeostasis

                                                                                                                                                                                                      Etiology

                                                                                                                                                                                                      1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                                                      inadequate supplementation of magnesium)

                                                                                                                                                                                                      2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                                                      3 GI losses (diarrhea)

                                                                                                                                                                                                      4 Malabsorption

                                                                                                                                                                                                      5 Acute pancreatitis

                                                                                                                                                                                                      6 Diabetic ketoacidosis

                                                                                                                                                                                                      7 Primary aldosteronism

                                                                                                                                                                                                      Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                                      1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                                      2 Delirium and seizures in severe deficiency

                                                                                                                                                                                                      3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                                      ST-segment depression

                                                                                                                                                                                                      Flattening or inversion of P waves

                                                                                                                                                                                                      Torsades de pointes

                                                                                                                                                                                                      Arrhythmia

                                                                                                                                                                                                      Treatment

                                                                                                                                                                                                      1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                                      2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                                      Message for Today

                                                                                                                                                                                                      ICF

                                                                                                                                                                                                      Interstitial

                                                                                                                                                                                                      Pla

                                                                                                                                                                                                      sma

                                                                                                                                                                                                      5 Dex

                                                                                                                                                                                                      bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                                      • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                                      • Slide 2
                                                                                                                                                                                                      • Slide 3
                                                                                                                                                                                                      • Slide 4
                                                                                                                                                                                                      • Total Body Water
                                                                                                                                                                                                      • Body Fluid Compartments
                                                                                                                                                                                                      • Total body water (TBW)
                                                                                                                                                                                                      • Body compartment fluid
                                                                                                                                                                                                      • Example men with 70kg
                                                                                                                                                                                                      • Fluid compartments
                                                                                                                                                                                                      • Slide 11
                                                                                                                                                                                                      • Slide 12
                                                                                                                                                                                                      • Slide 13
                                                                                                                                                                                                      • Slide 14
                                                                                                                                                                                                      • Slide 15
                                                                                                                                                                                                      • Colloid osmotic pressure
                                                                                                                                                                                                      • Slide 17
                                                                                                                                                                                                      • Slide 18
                                                                                                                                                                                                      • Slide 19
                                                                                                                                                                                                      • Cell Membrane
                                                                                                                                                                                                      • Slide 21
                                                                                                                                                                                                      • Slide 22
                                                                                                                                                                                                      • Slide 23
                                                                                                                                                                                                      • Slide 24
                                                                                                                                                                                                      • Slide 25
                                                                                                                                                                                                      • Composition of Fluid Compartments
                                                                                                                                                                                                      • Composition of Body Fluids
                                                                                                                                                                                                      • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                                      • Reasons for fluid therapy
                                                                                                                                                                                                      • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                                      • محلولهای وریدی
                                                                                                                                                                                                      • Fluids
                                                                                                                                                                                                      • Slide 33
                                                                                                                                                                                                      • Slide 34
                                                                                                                                                                                                      • Slide 35
                                                                                                                                                                                                      • Crystalloids
                                                                                                                                                                                                      • Colloid Solutions
                                                                                                                                                                                                      • رینگر لاکتات
                                                                                                                                                                                                      • 09Nacl
                                                                                                                                                                                                      • Postoperative (maintenance)
                                                                                                                                                                                                      • Slide 41
                                                                                                                                                                                                      • Preexisting fluid deficits
                                                                                                                                                                                                      • Maintenance requirements
                                                                                                                                                                                                      • Surgical fluid losses
                                                                                                                                                                                                      • Third space loss
                                                                                                                                                                                                      • Crystalloid solution
                                                                                                                                                                                                      • Colloids
                                                                                                                                                                                                      • Complications
                                                                                                                                                                                                      • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                                      • Colloid versus crystalloid solutions
                                                                                                                                                                                                      • Transfusion consideration
                                                                                                                                                                                                      • اختلال در حجم مایعات بدن
                                                                                                                                                                                                      • Fluid volume deficit (FVD)
                                                                                                                                                                                                      • DEHYDRATION
                                                                                                                                                                                                      • علل کاهش حجم خارج سلولی
                                                                                                                                                                                                      • Signs of Hypovolemia
                                                                                                                                                                                                      • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                                      • Signs of Hypervolemia
                                                                                                                                                                                                      • Management of Hypervolemia
                                                                                                                                                                                                      • Fluid Management
                                                                                                                                                                                                      • Electrolyte physiology
                                                                                                                                                                                                      • Sodium physiology
                                                                                                                                                                                                      • Osmotic Pressure
                                                                                                                                                                                                      • Concentration
                                                                                                                                                                                                      • Hypernatremia
                                                                                                                                                                                                      • - Hypernatremia
                                                                                                                                                                                                      • Slide 67
                                                                                                                                                                                                      • Slide 68
                                                                                                                                                                                                      • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                                      • Treatment
                                                                                                                                                                                                      • Water deficit (L)= times TBW
                                                                                                                                                                                                      • The rate of fluid administration
                                                                                                                                                                                                      • Hyponatremia Nalt135mEqL
                                                                                                                                                                                                      • Slide 74
                                                                                                                                                                                                      • Sodium depletion
                                                                                                                                                                                                      • Sodium dilution
                                                                                                                                                                                                      • Sign and symptoms
                                                                                                                                                                                                      • Slide 78
                                                                                                                                                                                                      • Treatment
                                                                                                                                                                                                      • Slide 80
                                                                                                                                                                                                      • Slide 81
                                                                                                                                                                                                      • Dose
                                                                                                                                                                                                      • Potassium abnormalities
                                                                                                                                                                                                      • Hyperkalemia
                                                                                                                                                                                                      • Clinical manifestation of hyperkalemia
                                                                                                                                                                                                      • Slide 86
                                                                                                                                                                                                      • Slide 87
                                                                                                                                                                                                      • Hypokalemia
                                                                                                                                                                                                      • Potassium changes associated with alkalosis
                                                                                                                                                                                                      • Slide 90
                                                                                                                                                                                                      • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                                      • Slide 92
                                                                                                                                                                                                      • Calcium
                                                                                                                                                                                                      • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                                      • علائم هیپوکلسمی
                                                                                                                                                                                                      • Slide 96
                                                                                                                                                                                                      • Slide 97
                                                                                                                                                                                                      • Slide 98
                                                                                                                                                                                                      • Slide 99
                                                                                                                                                                                                      • سایرعلائم
                                                                                                                                                                                                      • درمان
                                                                                                                                                                                                      • هيپركلسمي Cagt55meql
                                                                                                                                                                                                      • علائم
                                                                                                                                                                                                      • علائم قلبی
                                                                                                                                                                                                      • Slide 105
                                                                                                                                                                                                      • Magnesium Abnormalities
                                                                                                                                                                                                      • منیزیوم
                                                                                                                                                                                                      • Hypermagnesemia
                                                                                                                                                                                                      • Clinical manifestation hypermanesemia
                                                                                                                                                                                                      • Slide 110
                                                                                                                                                                                                      • Slide 111
                                                                                                                                                                                                      • Hypomagnesemia
                                                                                                                                                                                                      • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                                      • Slide 114
                                                                                                                                                                                                      • Message for Today
                                                                                                                                                                                                      • Slide 116

                                                                                                                                                                                                        Magnesium Abnormalities

                                                                                                                                                                                                        Normal dietary intake 20meq (240mg)

                                                                                                                                                                                                        Excretion in both the feces and urine

                                                                                                                                                                                                        Normal serum level 19-25 mgdL

                                                                                                                                                                                                        منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                                                        تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                                                        bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                                                        Hypermagnesemia

                                                                                                                                                                                                        Etiology

                                                                                                                                                                                                        1 Impaired renal function

                                                                                                                                                                                                        2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                                                        Clinical manifestation hypermanesemia

                                                                                                                                                                                                        System hypermanesemia

                                                                                                                                                                                                        Gastrointestinal Nauseavomiting

                                                                                                                                                                                                        Neuromuscular weakness lethargy Decreased

                                                                                                                                                                                                        reflexes

                                                                                                                                                                                                        Cardiovascular Hypotension arrest

                                                                                                                                                                                                        ECG changes Increased PR interval

                                                                                                                                                                                                        Widened QRS complex

                                                                                                                                                                                                        Elevated T waves

                                                                                                                                                                                                        Treatment

                                                                                                                                                                                                        1 Withhold exogenous sources of magnesium

                                                                                                                                                                                                        2 Correct volume deficit

                                                                                                                                                                                                        3 Correct acidosis if present

                                                                                                                                                                                                        4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                                                        5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                                                        عالئم

                                                                                                                                                                                                        bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                                                        meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                                                        meqL

                                                                                                                                                                                                        Hypomagnesemia

                                                                                                                                                                                                        Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                                                        homeostasis

                                                                                                                                                                                                        Etiology

                                                                                                                                                                                                        1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                                                        inadequate supplementation of magnesium)

                                                                                                                                                                                                        2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                                                        3 GI losses (diarrhea)

                                                                                                                                                                                                        4 Malabsorption

                                                                                                                                                                                                        5 Acute pancreatitis

                                                                                                                                                                                                        6 Diabetic ketoacidosis

                                                                                                                                                                                                        7 Primary aldosteronism

                                                                                                                                                                                                        Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                                        1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                                        2 Delirium and seizures in severe deficiency

                                                                                                                                                                                                        3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                                        ST-segment depression

                                                                                                                                                                                                        Flattening or inversion of P waves

                                                                                                                                                                                                        Torsades de pointes

                                                                                                                                                                                                        Arrhythmia

                                                                                                                                                                                                        Treatment

                                                                                                                                                                                                        1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                                        2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                                        Message for Today

                                                                                                                                                                                                        ICF

                                                                                                                                                                                                        Interstitial

                                                                                                                                                                                                        Pla

                                                                                                                                                                                                        sma

                                                                                                                                                                                                        5 Dex

                                                                                                                                                                                                        bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                                        • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                                        • Slide 2
                                                                                                                                                                                                        • Slide 3
                                                                                                                                                                                                        • Slide 4
                                                                                                                                                                                                        • Total Body Water
                                                                                                                                                                                                        • Body Fluid Compartments
                                                                                                                                                                                                        • Total body water (TBW)
                                                                                                                                                                                                        • Body compartment fluid
                                                                                                                                                                                                        • Example men with 70kg
                                                                                                                                                                                                        • Fluid compartments
                                                                                                                                                                                                        • Slide 11
                                                                                                                                                                                                        • Slide 12
                                                                                                                                                                                                        • Slide 13
                                                                                                                                                                                                        • Slide 14
                                                                                                                                                                                                        • Slide 15
                                                                                                                                                                                                        • Colloid osmotic pressure
                                                                                                                                                                                                        • Slide 17
                                                                                                                                                                                                        • Slide 18
                                                                                                                                                                                                        • Slide 19
                                                                                                                                                                                                        • Cell Membrane
                                                                                                                                                                                                        • Slide 21
                                                                                                                                                                                                        • Slide 22
                                                                                                                                                                                                        • Slide 23
                                                                                                                                                                                                        • Slide 24
                                                                                                                                                                                                        • Slide 25
                                                                                                                                                                                                        • Composition of Fluid Compartments
                                                                                                                                                                                                        • Composition of Body Fluids
                                                                                                                                                                                                        • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                                        • Reasons for fluid therapy
                                                                                                                                                                                                        • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                                        • محلولهای وریدی
                                                                                                                                                                                                        • Fluids
                                                                                                                                                                                                        • Slide 33
                                                                                                                                                                                                        • Slide 34
                                                                                                                                                                                                        • Slide 35
                                                                                                                                                                                                        • Crystalloids
                                                                                                                                                                                                        • Colloid Solutions
                                                                                                                                                                                                        • رینگر لاکتات
                                                                                                                                                                                                        • 09Nacl
                                                                                                                                                                                                        • Postoperative (maintenance)
                                                                                                                                                                                                        • Slide 41
                                                                                                                                                                                                        • Preexisting fluid deficits
                                                                                                                                                                                                        • Maintenance requirements
                                                                                                                                                                                                        • Surgical fluid losses
                                                                                                                                                                                                        • Third space loss
                                                                                                                                                                                                        • Crystalloid solution
                                                                                                                                                                                                        • Colloids
                                                                                                                                                                                                        • Complications
                                                                                                                                                                                                        • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                                        • Colloid versus crystalloid solutions
                                                                                                                                                                                                        • Transfusion consideration
                                                                                                                                                                                                        • اختلال در حجم مایعات بدن
                                                                                                                                                                                                        • Fluid volume deficit (FVD)
                                                                                                                                                                                                        • DEHYDRATION
                                                                                                                                                                                                        • علل کاهش حجم خارج سلولی
                                                                                                                                                                                                        • Signs of Hypovolemia
                                                                                                                                                                                                        • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                                        • Signs of Hypervolemia
                                                                                                                                                                                                        • Management of Hypervolemia
                                                                                                                                                                                                        • Fluid Management
                                                                                                                                                                                                        • Electrolyte physiology
                                                                                                                                                                                                        • Sodium physiology
                                                                                                                                                                                                        • Osmotic Pressure
                                                                                                                                                                                                        • Concentration
                                                                                                                                                                                                        • Hypernatremia
                                                                                                                                                                                                        • - Hypernatremia
                                                                                                                                                                                                        • Slide 67
                                                                                                                                                                                                        • Slide 68
                                                                                                                                                                                                        • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                                        • Treatment
                                                                                                                                                                                                        • Water deficit (L)= times TBW
                                                                                                                                                                                                        • The rate of fluid administration
                                                                                                                                                                                                        • Hyponatremia Nalt135mEqL
                                                                                                                                                                                                        • Slide 74
                                                                                                                                                                                                        • Sodium depletion
                                                                                                                                                                                                        • Sodium dilution
                                                                                                                                                                                                        • Sign and symptoms
                                                                                                                                                                                                        • Slide 78
                                                                                                                                                                                                        • Treatment
                                                                                                                                                                                                        • Slide 80
                                                                                                                                                                                                        • Slide 81
                                                                                                                                                                                                        • Dose
                                                                                                                                                                                                        • Potassium abnormalities
                                                                                                                                                                                                        • Hyperkalemia
                                                                                                                                                                                                        • Clinical manifestation of hyperkalemia
                                                                                                                                                                                                        • Slide 86
                                                                                                                                                                                                        • Slide 87
                                                                                                                                                                                                        • Hypokalemia
                                                                                                                                                                                                        • Potassium changes associated with alkalosis
                                                                                                                                                                                                        • Slide 90
                                                                                                                                                                                                        • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                                        • Slide 92
                                                                                                                                                                                                        • Calcium
                                                                                                                                                                                                        • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                                        • علائم هیپوکلسمی
                                                                                                                                                                                                        • Slide 96
                                                                                                                                                                                                        • Slide 97
                                                                                                                                                                                                        • Slide 98
                                                                                                                                                                                                        • Slide 99
                                                                                                                                                                                                        • سایرعلائم
                                                                                                                                                                                                        • درمان
                                                                                                                                                                                                        • هيپركلسمي Cagt55meql
                                                                                                                                                                                                        • علائم
                                                                                                                                                                                                        • علائم قلبی
                                                                                                                                                                                                        • Slide 105
                                                                                                                                                                                                        • Magnesium Abnormalities
                                                                                                                                                                                                        • منیزیوم
                                                                                                                                                                                                        • Hypermagnesemia
                                                                                                                                                                                                        • Clinical manifestation hypermanesemia
                                                                                                                                                                                                        • Slide 110
                                                                                                                                                                                                        • Slide 111
                                                                                                                                                                                                        • Hypomagnesemia
                                                                                                                                                                                                        • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                                        • Slide 114
                                                                                                                                                                                                        • Message for Today
                                                                                                                                                                                                        • Slide 116

                                                                                                                                                                                                          منیزیومbull است سلولی داخل فراوان کاتیون دومینهای bull واکنش در کمکی فاکتور عنوان به آن نقش

                                                                                                                                                                                                          تون و قلب انقباضی قدرت حفظ در و آنزیمی دارد محیطی عروق

                                                                                                                                                                                                          bull55 ( و ( فعال یونیزه شکل پروتئین 45به بانداست

                                                                                                                                                                                                          Hypermagnesemia

                                                                                                                                                                                                          Etiology

                                                                                                                                                                                                          1 Impaired renal function

                                                                                                                                                                                                          2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                                                          Clinical manifestation hypermanesemia

                                                                                                                                                                                                          System hypermanesemia

                                                                                                                                                                                                          Gastrointestinal Nauseavomiting

                                                                                                                                                                                                          Neuromuscular weakness lethargy Decreased

                                                                                                                                                                                                          reflexes

                                                                                                                                                                                                          Cardiovascular Hypotension arrest

                                                                                                                                                                                                          ECG changes Increased PR interval

                                                                                                                                                                                                          Widened QRS complex

                                                                                                                                                                                                          Elevated T waves

                                                                                                                                                                                                          Treatment

                                                                                                                                                                                                          1 Withhold exogenous sources of magnesium

                                                                                                                                                                                                          2 Correct volume deficit

                                                                                                                                                                                                          3 Correct acidosis if present

                                                                                                                                                                                                          4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                                                          5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                                                          عالئم

                                                                                                                                                                                                          bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                                                          meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                                                          meqL

                                                                                                                                                                                                          Hypomagnesemia

                                                                                                                                                                                                          Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                                                          homeostasis

                                                                                                                                                                                                          Etiology

                                                                                                                                                                                                          1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                                                          inadequate supplementation of magnesium)

                                                                                                                                                                                                          2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                                                          3 GI losses (diarrhea)

                                                                                                                                                                                                          4 Malabsorption

                                                                                                                                                                                                          5 Acute pancreatitis

                                                                                                                                                                                                          6 Diabetic ketoacidosis

                                                                                                                                                                                                          7 Primary aldosteronism

                                                                                                                                                                                                          Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                                          1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                                          2 Delirium and seizures in severe deficiency

                                                                                                                                                                                                          3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                                          ST-segment depression

                                                                                                                                                                                                          Flattening or inversion of P waves

                                                                                                                                                                                                          Torsades de pointes

                                                                                                                                                                                                          Arrhythmia

                                                                                                                                                                                                          Treatment

                                                                                                                                                                                                          1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                                          2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                                          Message for Today

                                                                                                                                                                                                          ICF

                                                                                                                                                                                                          Interstitial

                                                                                                                                                                                                          Pla

                                                                                                                                                                                                          sma

                                                                                                                                                                                                          5 Dex

                                                                                                                                                                                                          bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                                          • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                                          • Slide 2
                                                                                                                                                                                                          • Slide 3
                                                                                                                                                                                                          • Slide 4
                                                                                                                                                                                                          • Total Body Water
                                                                                                                                                                                                          • Body Fluid Compartments
                                                                                                                                                                                                          • Total body water (TBW)
                                                                                                                                                                                                          • Body compartment fluid
                                                                                                                                                                                                          • Example men with 70kg
                                                                                                                                                                                                          • Fluid compartments
                                                                                                                                                                                                          • Slide 11
                                                                                                                                                                                                          • Slide 12
                                                                                                                                                                                                          • Slide 13
                                                                                                                                                                                                          • Slide 14
                                                                                                                                                                                                          • Slide 15
                                                                                                                                                                                                          • Colloid osmotic pressure
                                                                                                                                                                                                          • Slide 17
                                                                                                                                                                                                          • Slide 18
                                                                                                                                                                                                          • Slide 19
                                                                                                                                                                                                          • Cell Membrane
                                                                                                                                                                                                          • Slide 21
                                                                                                                                                                                                          • Slide 22
                                                                                                                                                                                                          • Slide 23
                                                                                                                                                                                                          • Slide 24
                                                                                                                                                                                                          • Slide 25
                                                                                                                                                                                                          • Composition of Fluid Compartments
                                                                                                                                                                                                          • Composition of Body Fluids
                                                                                                                                                                                                          • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                                          • Reasons for fluid therapy
                                                                                                                                                                                                          • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                                          • محلولهای وریدی
                                                                                                                                                                                                          • Fluids
                                                                                                                                                                                                          • Slide 33
                                                                                                                                                                                                          • Slide 34
                                                                                                                                                                                                          • Slide 35
                                                                                                                                                                                                          • Crystalloids
                                                                                                                                                                                                          • Colloid Solutions
                                                                                                                                                                                                          • رینگر لاکتات
                                                                                                                                                                                                          • 09Nacl
                                                                                                                                                                                                          • Postoperative (maintenance)
                                                                                                                                                                                                          • Slide 41
                                                                                                                                                                                                          • Preexisting fluid deficits
                                                                                                                                                                                                          • Maintenance requirements
                                                                                                                                                                                                          • Surgical fluid losses
                                                                                                                                                                                                          • Third space loss
                                                                                                                                                                                                          • Crystalloid solution
                                                                                                                                                                                                          • Colloids
                                                                                                                                                                                                          • Complications
                                                                                                                                                                                                          • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                                          • Colloid versus crystalloid solutions
                                                                                                                                                                                                          • Transfusion consideration
                                                                                                                                                                                                          • اختلال در حجم مایعات بدن
                                                                                                                                                                                                          • Fluid volume deficit (FVD)
                                                                                                                                                                                                          • DEHYDRATION
                                                                                                                                                                                                          • علل کاهش حجم خارج سلولی
                                                                                                                                                                                                          • Signs of Hypovolemia
                                                                                                                                                                                                          • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                                          • Signs of Hypervolemia
                                                                                                                                                                                                          • Management of Hypervolemia
                                                                                                                                                                                                          • Fluid Management
                                                                                                                                                                                                          • Electrolyte physiology
                                                                                                                                                                                                          • Sodium physiology
                                                                                                                                                                                                          • Osmotic Pressure
                                                                                                                                                                                                          • Concentration
                                                                                                                                                                                                          • Hypernatremia
                                                                                                                                                                                                          • - Hypernatremia
                                                                                                                                                                                                          • Slide 67
                                                                                                                                                                                                          • Slide 68
                                                                                                                                                                                                          • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                                          • Treatment
                                                                                                                                                                                                          • Water deficit (L)= times TBW
                                                                                                                                                                                                          • The rate of fluid administration
                                                                                                                                                                                                          • Hyponatremia Nalt135mEqL
                                                                                                                                                                                                          • Slide 74
                                                                                                                                                                                                          • Sodium depletion
                                                                                                                                                                                                          • Sodium dilution
                                                                                                                                                                                                          • Sign and symptoms
                                                                                                                                                                                                          • Slide 78
                                                                                                                                                                                                          • Treatment
                                                                                                                                                                                                          • Slide 80
                                                                                                                                                                                                          • Slide 81
                                                                                                                                                                                                          • Dose
                                                                                                                                                                                                          • Potassium abnormalities
                                                                                                                                                                                                          • Hyperkalemia
                                                                                                                                                                                                          • Clinical manifestation of hyperkalemia
                                                                                                                                                                                                          • Slide 86
                                                                                                                                                                                                          • Slide 87
                                                                                                                                                                                                          • Hypokalemia
                                                                                                                                                                                                          • Potassium changes associated with alkalosis
                                                                                                                                                                                                          • Slide 90
                                                                                                                                                                                                          • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                                          • Slide 92
                                                                                                                                                                                                          • Calcium
                                                                                                                                                                                                          • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                                          • علائم هیپوکلسمی
                                                                                                                                                                                                          • Slide 96
                                                                                                                                                                                                          • Slide 97
                                                                                                                                                                                                          • Slide 98
                                                                                                                                                                                                          • Slide 99
                                                                                                                                                                                                          • سایرعلائم
                                                                                                                                                                                                          • درمان
                                                                                                                                                                                                          • هيپركلسمي Cagt55meql
                                                                                                                                                                                                          • علائم
                                                                                                                                                                                                          • علائم قلبی
                                                                                                                                                                                                          • Slide 105
                                                                                                                                                                                                          • Magnesium Abnormalities
                                                                                                                                                                                                          • منیزیوم
                                                                                                                                                                                                          • Hypermagnesemia
                                                                                                                                                                                                          • Clinical manifestation hypermanesemia
                                                                                                                                                                                                          • Slide 110
                                                                                                                                                                                                          • Slide 111
                                                                                                                                                                                                          • Hypomagnesemia
                                                                                                                                                                                                          • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                                          • Slide 114
                                                                                                                                                                                                          • Message for Today
                                                                                                                                                                                                          • Slide 116

                                                                                                                                                                                                            Hypermagnesemia

                                                                                                                                                                                                            Etiology

                                                                                                                                                                                                            1 Impaired renal function

                                                                                                                                                                                                            2 Excess intake (in the from of TPN or magnesium-containing laxatives and antacids)

                                                                                                                                                                                                            Clinical manifestation hypermanesemia

                                                                                                                                                                                                            System hypermanesemia

                                                                                                                                                                                                            Gastrointestinal Nauseavomiting

                                                                                                                                                                                                            Neuromuscular weakness lethargy Decreased

                                                                                                                                                                                                            reflexes

                                                                                                                                                                                                            Cardiovascular Hypotension arrest

                                                                                                                                                                                                            ECG changes Increased PR interval

                                                                                                                                                                                                            Widened QRS complex

                                                                                                                                                                                                            Elevated T waves

                                                                                                                                                                                                            Treatment

                                                                                                                                                                                                            1 Withhold exogenous sources of magnesium

                                                                                                                                                                                                            2 Correct volume deficit

                                                                                                                                                                                                            3 Correct acidosis if present

                                                                                                                                                                                                            4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                                                            5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                                                            عالئم

                                                                                                                                                                                                            bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                                                            meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                                                            meqL

                                                                                                                                                                                                            Hypomagnesemia

                                                                                                                                                                                                            Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                                                            homeostasis

                                                                                                                                                                                                            Etiology

                                                                                                                                                                                                            1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                                                            inadequate supplementation of magnesium)

                                                                                                                                                                                                            2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                                                            3 GI losses (diarrhea)

                                                                                                                                                                                                            4 Malabsorption

                                                                                                                                                                                                            5 Acute pancreatitis

                                                                                                                                                                                                            6 Diabetic ketoacidosis

                                                                                                                                                                                                            7 Primary aldosteronism

                                                                                                                                                                                                            Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                                            1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                                            2 Delirium and seizures in severe deficiency

                                                                                                                                                                                                            3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                                            ST-segment depression

                                                                                                                                                                                                            Flattening or inversion of P waves

                                                                                                                                                                                                            Torsades de pointes

                                                                                                                                                                                                            Arrhythmia

                                                                                                                                                                                                            Treatment

                                                                                                                                                                                                            1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                                            2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                                            Message for Today

                                                                                                                                                                                                            ICF

                                                                                                                                                                                                            Interstitial

                                                                                                                                                                                                            Pla

                                                                                                                                                                                                            sma

                                                                                                                                                                                                            5 Dex

                                                                                                                                                                                                            bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                                            • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                                            • Slide 2
                                                                                                                                                                                                            • Slide 3
                                                                                                                                                                                                            • Slide 4
                                                                                                                                                                                                            • Total Body Water
                                                                                                                                                                                                            • Body Fluid Compartments
                                                                                                                                                                                                            • Total body water (TBW)
                                                                                                                                                                                                            • Body compartment fluid
                                                                                                                                                                                                            • Example men with 70kg
                                                                                                                                                                                                            • Fluid compartments
                                                                                                                                                                                                            • Slide 11
                                                                                                                                                                                                            • Slide 12
                                                                                                                                                                                                            • Slide 13
                                                                                                                                                                                                            • Slide 14
                                                                                                                                                                                                            • Slide 15
                                                                                                                                                                                                            • Colloid osmotic pressure
                                                                                                                                                                                                            • Slide 17
                                                                                                                                                                                                            • Slide 18
                                                                                                                                                                                                            • Slide 19
                                                                                                                                                                                                            • Cell Membrane
                                                                                                                                                                                                            • Slide 21
                                                                                                                                                                                                            • Slide 22
                                                                                                                                                                                                            • Slide 23
                                                                                                                                                                                                            • Slide 24
                                                                                                                                                                                                            • Slide 25
                                                                                                                                                                                                            • Composition of Fluid Compartments
                                                                                                                                                                                                            • Composition of Body Fluids
                                                                                                                                                                                                            • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                                            • Reasons for fluid therapy
                                                                                                                                                                                                            • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                                            • محلولهای وریدی
                                                                                                                                                                                                            • Fluids
                                                                                                                                                                                                            • Slide 33
                                                                                                                                                                                                            • Slide 34
                                                                                                                                                                                                            • Slide 35
                                                                                                                                                                                                            • Crystalloids
                                                                                                                                                                                                            • Colloid Solutions
                                                                                                                                                                                                            • رینگر لاکتات
                                                                                                                                                                                                            • 09Nacl
                                                                                                                                                                                                            • Postoperative (maintenance)
                                                                                                                                                                                                            • Slide 41
                                                                                                                                                                                                            • Preexisting fluid deficits
                                                                                                                                                                                                            • Maintenance requirements
                                                                                                                                                                                                            • Surgical fluid losses
                                                                                                                                                                                                            • Third space loss
                                                                                                                                                                                                            • Crystalloid solution
                                                                                                                                                                                                            • Colloids
                                                                                                                                                                                                            • Complications
                                                                                                                                                                                                            • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                                            • Colloid versus crystalloid solutions
                                                                                                                                                                                                            • Transfusion consideration
                                                                                                                                                                                                            • اختلال در حجم مایعات بدن
                                                                                                                                                                                                            • Fluid volume deficit (FVD)
                                                                                                                                                                                                            • DEHYDRATION
                                                                                                                                                                                                            • علل کاهش حجم خارج سلولی
                                                                                                                                                                                                            • Signs of Hypovolemia
                                                                                                                                                                                                            • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                                            • Signs of Hypervolemia
                                                                                                                                                                                                            • Management of Hypervolemia
                                                                                                                                                                                                            • Fluid Management
                                                                                                                                                                                                            • Electrolyte physiology
                                                                                                                                                                                                            • Sodium physiology
                                                                                                                                                                                                            • Osmotic Pressure
                                                                                                                                                                                                            • Concentration
                                                                                                                                                                                                            • Hypernatremia
                                                                                                                                                                                                            • - Hypernatremia
                                                                                                                                                                                                            • Slide 67
                                                                                                                                                                                                            • Slide 68
                                                                                                                                                                                                            • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                                            • Treatment
                                                                                                                                                                                                            • Water deficit (L)= times TBW
                                                                                                                                                                                                            • The rate of fluid administration
                                                                                                                                                                                                            • Hyponatremia Nalt135mEqL
                                                                                                                                                                                                            • Slide 74
                                                                                                                                                                                                            • Sodium depletion
                                                                                                                                                                                                            • Sodium dilution
                                                                                                                                                                                                            • Sign and symptoms
                                                                                                                                                                                                            • Slide 78
                                                                                                                                                                                                            • Treatment
                                                                                                                                                                                                            • Slide 80
                                                                                                                                                                                                            • Slide 81
                                                                                                                                                                                                            • Dose
                                                                                                                                                                                                            • Potassium abnormalities
                                                                                                                                                                                                            • Hyperkalemia
                                                                                                                                                                                                            • Clinical manifestation of hyperkalemia
                                                                                                                                                                                                            • Slide 86
                                                                                                                                                                                                            • Slide 87
                                                                                                                                                                                                            • Hypokalemia
                                                                                                                                                                                                            • Potassium changes associated with alkalosis
                                                                                                                                                                                                            • Slide 90
                                                                                                                                                                                                            • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                                            • Slide 92
                                                                                                                                                                                                            • Calcium
                                                                                                                                                                                                            • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                                            • علائم هیپوکلسمی
                                                                                                                                                                                                            • Slide 96
                                                                                                                                                                                                            • Slide 97
                                                                                                                                                                                                            • Slide 98
                                                                                                                                                                                                            • Slide 99
                                                                                                                                                                                                            • سایرعلائم
                                                                                                                                                                                                            • درمان
                                                                                                                                                                                                            • هيپركلسمي Cagt55meql
                                                                                                                                                                                                            • علائم
                                                                                                                                                                                                            • علائم قلبی
                                                                                                                                                                                                            • Slide 105
                                                                                                                                                                                                            • Magnesium Abnormalities
                                                                                                                                                                                                            • منیزیوم
                                                                                                                                                                                                            • Hypermagnesemia
                                                                                                                                                                                                            • Clinical manifestation hypermanesemia
                                                                                                                                                                                                            • Slide 110
                                                                                                                                                                                                            • Slide 111
                                                                                                                                                                                                            • Hypomagnesemia
                                                                                                                                                                                                            • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                                            • Slide 114
                                                                                                                                                                                                            • Message for Today
                                                                                                                                                                                                            • Slide 116

                                                                                                                                                                                                              Clinical manifestation hypermanesemia

                                                                                                                                                                                                              System hypermanesemia

                                                                                                                                                                                                              Gastrointestinal Nauseavomiting

                                                                                                                                                                                                              Neuromuscular weakness lethargy Decreased

                                                                                                                                                                                                              reflexes

                                                                                                                                                                                                              Cardiovascular Hypotension arrest

                                                                                                                                                                                                              ECG changes Increased PR interval

                                                                                                                                                                                                              Widened QRS complex

                                                                                                                                                                                                              Elevated T waves

                                                                                                                                                                                                              Treatment

                                                                                                                                                                                                              1 Withhold exogenous sources of magnesium

                                                                                                                                                                                                              2 Correct volume deficit

                                                                                                                                                                                                              3 Correct acidosis if present

                                                                                                                                                                                                              4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                                                              5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                                                              عالئم

                                                                                                                                                                                                              bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                                                              meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                                                              meqL

                                                                                                                                                                                                              Hypomagnesemia

                                                                                                                                                                                                              Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                                                              homeostasis

                                                                                                                                                                                                              Etiology

                                                                                                                                                                                                              1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                                                              inadequate supplementation of magnesium)

                                                                                                                                                                                                              2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                                                              3 GI losses (diarrhea)

                                                                                                                                                                                                              4 Malabsorption

                                                                                                                                                                                                              5 Acute pancreatitis

                                                                                                                                                                                                              6 Diabetic ketoacidosis

                                                                                                                                                                                                              7 Primary aldosteronism

                                                                                                                                                                                                              Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                                              1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                                              2 Delirium and seizures in severe deficiency

                                                                                                                                                                                                              3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                                              ST-segment depression

                                                                                                                                                                                                              Flattening or inversion of P waves

                                                                                                                                                                                                              Torsades de pointes

                                                                                                                                                                                                              Arrhythmia

                                                                                                                                                                                                              Treatment

                                                                                                                                                                                                              1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                                              2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                                              Message for Today

                                                                                                                                                                                                              ICF

                                                                                                                                                                                                              Interstitial

                                                                                                                                                                                                              Pla

                                                                                                                                                                                                              sma

                                                                                                                                                                                                              5 Dex

                                                                                                                                                                                                              bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                                              • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                                              • Slide 2
                                                                                                                                                                                                              • Slide 3
                                                                                                                                                                                                              • Slide 4
                                                                                                                                                                                                              • Total Body Water
                                                                                                                                                                                                              • Body Fluid Compartments
                                                                                                                                                                                                              • Total body water (TBW)
                                                                                                                                                                                                              • Body compartment fluid
                                                                                                                                                                                                              • Example men with 70kg
                                                                                                                                                                                                              • Fluid compartments
                                                                                                                                                                                                              • Slide 11
                                                                                                                                                                                                              • Slide 12
                                                                                                                                                                                                              • Slide 13
                                                                                                                                                                                                              • Slide 14
                                                                                                                                                                                                              • Slide 15
                                                                                                                                                                                                              • Colloid osmotic pressure
                                                                                                                                                                                                              • Slide 17
                                                                                                                                                                                                              • Slide 18
                                                                                                                                                                                                              • Slide 19
                                                                                                                                                                                                              • Cell Membrane
                                                                                                                                                                                                              • Slide 21
                                                                                                                                                                                                              • Slide 22
                                                                                                                                                                                                              • Slide 23
                                                                                                                                                                                                              • Slide 24
                                                                                                                                                                                                              • Slide 25
                                                                                                                                                                                                              • Composition of Fluid Compartments
                                                                                                                                                                                                              • Composition of Body Fluids
                                                                                                                                                                                                              • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                                              • Reasons for fluid therapy
                                                                                                                                                                                                              • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                                              • محلولهای وریدی
                                                                                                                                                                                                              • Fluids
                                                                                                                                                                                                              • Slide 33
                                                                                                                                                                                                              • Slide 34
                                                                                                                                                                                                              • Slide 35
                                                                                                                                                                                                              • Crystalloids
                                                                                                                                                                                                              • Colloid Solutions
                                                                                                                                                                                                              • رینگر لاکتات
                                                                                                                                                                                                              • 09Nacl
                                                                                                                                                                                                              • Postoperative (maintenance)
                                                                                                                                                                                                              • Slide 41
                                                                                                                                                                                                              • Preexisting fluid deficits
                                                                                                                                                                                                              • Maintenance requirements
                                                                                                                                                                                                              • Surgical fluid losses
                                                                                                                                                                                                              • Third space loss
                                                                                                                                                                                                              • Crystalloid solution
                                                                                                                                                                                                              • Colloids
                                                                                                                                                                                                              • Complications
                                                                                                                                                                                                              • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                                              • Colloid versus crystalloid solutions
                                                                                                                                                                                                              • Transfusion consideration
                                                                                                                                                                                                              • اختلال در حجم مایعات بدن
                                                                                                                                                                                                              • Fluid volume deficit (FVD)
                                                                                                                                                                                                              • DEHYDRATION
                                                                                                                                                                                                              • علل کاهش حجم خارج سلولی
                                                                                                                                                                                                              • Signs of Hypovolemia
                                                                                                                                                                                                              • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                                              • Signs of Hypervolemia
                                                                                                                                                                                                              • Management of Hypervolemia
                                                                                                                                                                                                              • Fluid Management
                                                                                                                                                                                                              • Electrolyte physiology
                                                                                                                                                                                                              • Sodium physiology
                                                                                                                                                                                                              • Osmotic Pressure
                                                                                                                                                                                                              • Concentration
                                                                                                                                                                                                              • Hypernatremia
                                                                                                                                                                                                              • - Hypernatremia
                                                                                                                                                                                                              • Slide 67
                                                                                                                                                                                                              • Slide 68
                                                                                                                                                                                                              • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                                              • Treatment
                                                                                                                                                                                                              • Water deficit (L)= times TBW
                                                                                                                                                                                                              • The rate of fluid administration
                                                                                                                                                                                                              • Hyponatremia Nalt135mEqL
                                                                                                                                                                                                              • Slide 74
                                                                                                                                                                                                              • Sodium depletion
                                                                                                                                                                                                              • Sodium dilution
                                                                                                                                                                                                              • Sign and symptoms
                                                                                                                                                                                                              • Slide 78
                                                                                                                                                                                                              • Treatment
                                                                                                                                                                                                              • Slide 80
                                                                                                                                                                                                              • Slide 81
                                                                                                                                                                                                              • Dose
                                                                                                                                                                                                              • Potassium abnormalities
                                                                                                                                                                                                              • Hyperkalemia
                                                                                                                                                                                                              • Clinical manifestation of hyperkalemia
                                                                                                                                                                                                              • Slide 86
                                                                                                                                                                                                              • Slide 87
                                                                                                                                                                                                              • Hypokalemia
                                                                                                                                                                                                              • Potassium changes associated with alkalosis
                                                                                                                                                                                                              • Slide 90
                                                                                                                                                                                                              • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                                              • Slide 92
                                                                                                                                                                                                              • Calcium
                                                                                                                                                                                                              • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                                              • علائم هیپوکلسمی
                                                                                                                                                                                                              • Slide 96
                                                                                                                                                                                                              • Slide 97
                                                                                                                                                                                                              • Slide 98
                                                                                                                                                                                                              • Slide 99
                                                                                                                                                                                                              • سایرعلائم
                                                                                                                                                                                                              • درمان
                                                                                                                                                                                                              • هيپركلسمي Cagt55meql
                                                                                                                                                                                                              • علائم
                                                                                                                                                                                                              • علائم قلبی
                                                                                                                                                                                                              • Slide 105
                                                                                                                                                                                                              • Magnesium Abnormalities
                                                                                                                                                                                                              • منیزیوم
                                                                                                                                                                                                              • Hypermagnesemia
                                                                                                                                                                                                              • Clinical manifestation hypermanesemia
                                                                                                                                                                                                              • Slide 110
                                                                                                                                                                                                              • Slide 111
                                                                                                                                                                                                              • Hypomagnesemia
                                                                                                                                                                                                              • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                                              • Slide 114
                                                                                                                                                                                                              • Message for Today
                                                                                                                                                                                                              • Slide 116

                                                                                                                                                                                                                Treatment

                                                                                                                                                                                                                1 Withhold exogenous sources of magnesium

                                                                                                                                                                                                                2 Correct volume deficit

                                                                                                                                                                                                                3 Correct acidosis if present

                                                                                                                                                                                                                4 Calcium chloride (5-10 ml) to manage acute symptoms (cardiovascular effects)

                                                                                                                                                                                                                5 Dialysis (if elevated levels or symptoms persist)

                                                                                                                                                                                                                عالئم

                                                                                                                                                                                                                bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                                                                meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                                                                meqL

                                                                                                                                                                                                                Hypomagnesemia

                                                                                                                                                                                                                Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                                                                homeostasis

                                                                                                                                                                                                                Etiology

                                                                                                                                                                                                                1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                                                                inadequate supplementation of magnesium)

                                                                                                                                                                                                                2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                                                                3 GI losses (diarrhea)

                                                                                                                                                                                                                4 Malabsorption

                                                                                                                                                                                                                5 Acute pancreatitis

                                                                                                                                                                                                                6 Diabetic ketoacidosis

                                                                                                                                                                                                                7 Primary aldosteronism

                                                                                                                                                                                                                Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                                                1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                                                2 Delirium and seizures in severe deficiency

                                                                                                                                                                                                                3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                                                ST-segment depression

                                                                                                                                                                                                                Flattening or inversion of P waves

                                                                                                                                                                                                                Torsades de pointes

                                                                                                                                                                                                                Arrhythmia

                                                                                                                                                                                                                Treatment

                                                                                                                                                                                                                1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                                                2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                                                Message for Today

                                                                                                                                                                                                                ICF

                                                                                                                                                                                                                Interstitial

                                                                                                                                                                                                                Pla

                                                                                                                                                                                                                sma

                                                                                                                                                                                                                5 Dex

                                                                                                                                                                                                                bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                                                • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                                                • Slide 2
                                                                                                                                                                                                                • Slide 3
                                                                                                                                                                                                                • Slide 4
                                                                                                                                                                                                                • Total Body Water
                                                                                                                                                                                                                • Body Fluid Compartments
                                                                                                                                                                                                                • Total body water (TBW)
                                                                                                                                                                                                                • Body compartment fluid
                                                                                                                                                                                                                • Example men with 70kg
                                                                                                                                                                                                                • Fluid compartments
                                                                                                                                                                                                                • Slide 11
                                                                                                                                                                                                                • Slide 12
                                                                                                                                                                                                                • Slide 13
                                                                                                                                                                                                                • Slide 14
                                                                                                                                                                                                                • Slide 15
                                                                                                                                                                                                                • Colloid osmotic pressure
                                                                                                                                                                                                                • Slide 17
                                                                                                                                                                                                                • Slide 18
                                                                                                                                                                                                                • Slide 19
                                                                                                                                                                                                                • Cell Membrane
                                                                                                                                                                                                                • Slide 21
                                                                                                                                                                                                                • Slide 22
                                                                                                                                                                                                                • Slide 23
                                                                                                                                                                                                                • Slide 24
                                                                                                                                                                                                                • Slide 25
                                                                                                                                                                                                                • Composition of Fluid Compartments
                                                                                                                                                                                                                • Composition of Body Fluids
                                                                                                                                                                                                                • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                                                • Reasons for fluid therapy
                                                                                                                                                                                                                • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                                                • محلولهای وریدی
                                                                                                                                                                                                                • Fluids
                                                                                                                                                                                                                • Slide 33
                                                                                                                                                                                                                • Slide 34
                                                                                                                                                                                                                • Slide 35
                                                                                                                                                                                                                • Crystalloids
                                                                                                                                                                                                                • Colloid Solutions
                                                                                                                                                                                                                • رینگر لاکتات
                                                                                                                                                                                                                • 09Nacl
                                                                                                                                                                                                                • Postoperative (maintenance)
                                                                                                                                                                                                                • Slide 41
                                                                                                                                                                                                                • Preexisting fluid deficits
                                                                                                                                                                                                                • Maintenance requirements
                                                                                                                                                                                                                • Surgical fluid losses
                                                                                                                                                                                                                • Third space loss
                                                                                                                                                                                                                • Crystalloid solution
                                                                                                                                                                                                                • Colloids
                                                                                                                                                                                                                • Complications
                                                                                                                                                                                                                • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                                                • Colloid versus crystalloid solutions
                                                                                                                                                                                                                • Transfusion consideration
                                                                                                                                                                                                                • اختلال در حجم مایعات بدن
                                                                                                                                                                                                                • Fluid volume deficit (FVD)
                                                                                                                                                                                                                • DEHYDRATION
                                                                                                                                                                                                                • علل کاهش حجم خارج سلولی
                                                                                                                                                                                                                • Signs of Hypovolemia
                                                                                                                                                                                                                • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                                                • Signs of Hypervolemia
                                                                                                                                                                                                                • Management of Hypervolemia
                                                                                                                                                                                                                • Fluid Management
                                                                                                                                                                                                                • Electrolyte physiology
                                                                                                                                                                                                                • Sodium physiology
                                                                                                                                                                                                                • Osmotic Pressure
                                                                                                                                                                                                                • Concentration
                                                                                                                                                                                                                • Hypernatremia
                                                                                                                                                                                                                • - Hypernatremia
                                                                                                                                                                                                                • Slide 67
                                                                                                                                                                                                                • Slide 68
                                                                                                                                                                                                                • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                                                • Treatment
                                                                                                                                                                                                                • Water deficit (L)= times TBW
                                                                                                                                                                                                                • The rate of fluid administration
                                                                                                                                                                                                                • Hyponatremia Nalt135mEqL
                                                                                                                                                                                                                • Slide 74
                                                                                                                                                                                                                • Sodium depletion
                                                                                                                                                                                                                • Sodium dilution
                                                                                                                                                                                                                • Sign and symptoms
                                                                                                                                                                                                                • Slide 78
                                                                                                                                                                                                                • Treatment
                                                                                                                                                                                                                • Slide 80
                                                                                                                                                                                                                • Slide 81
                                                                                                                                                                                                                • Dose
                                                                                                                                                                                                                • Potassium abnormalities
                                                                                                                                                                                                                • Hyperkalemia
                                                                                                                                                                                                                • Clinical manifestation of hyperkalemia
                                                                                                                                                                                                                • Slide 86
                                                                                                                                                                                                                • Slide 87
                                                                                                                                                                                                                • Hypokalemia
                                                                                                                                                                                                                • Potassium changes associated with alkalosis
                                                                                                                                                                                                                • Slide 90
                                                                                                                                                                                                                • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                                                • Slide 92
                                                                                                                                                                                                                • Calcium
                                                                                                                                                                                                                • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                                                • علائم هیپوکلسمی
                                                                                                                                                                                                                • Slide 96
                                                                                                                                                                                                                • Slide 97
                                                                                                                                                                                                                • Slide 98
                                                                                                                                                                                                                • Slide 99
                                                                                                                                                                                                                • سایرعلائم
                                                                                                                                                                                                                • درمان
                                                                                                                                                                                                                • هيپركلسمي Cagt55meql
                                                                                                                                                                                                                • علائم
                                                                                                                                                                                                                • علائم قلبی
                                                                                                                                                                                                                • Slide 105
                                                                                                                                                                                                                • Magnesium Abnormalities
                                                                                                                                                                                                                • منیزیوم
                                                                                                                                                                                                                • Hypermagnesemia
                                                                                                                                                                                                                • Clinical manifestation hypermanesemia
                                                                                                                                                                                                                • Slide 110
                                                                                                                                                                                                                • Slide 111
                                                                                                                                                                                                                • Hypomagnesemia
                                                                                                                                                                                                                • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                                                • Slide 114
                                                                                                                                                                                                                • Message for Today
                                                                                                                                                                                                                • Slide 116

                                                                                                                                                                                                                  عالئم

                                                                                                                                                                                                                  bull Patellar reflexes lost 8-10 meqLbull Respiratory depression 10-15

                                                                                                                                                                                                                  meqLbull Respiratory paralysis 12-15 meqLbull Cardiac arrest 25-30

                                                                                                                                                                                                                  meqL

                                                                                                                                                                                                                  Hypomagnesemia

                                                                                                                                                                                                                  Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                                                                  homeostasis

                                                                                                                                                                                                                  Etiology

                                                                                                                                                                                                                  1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                                                                  inadequate supplementation of magnesium)

                                                                                                                                                                                                                  2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                                                                  3 GI losses (diarrhea)

                                                                                                                                                                                                                  4 Malabsorption

                                                                                                                                                                                                                  5 Acute pancreatitis

                                                                                                                                                                                                                  6 Diabetic ketoacidosis

                                                                                                                                                                                                                  7 Primary aldosteronism

                                                                                                                                                                                                                  Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                                                  1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                                                  2 Delirium and seizures in severe deficiency

                                                                                                                                                                                                                  3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                                                  ST-segment depression

                                                                                                                                                                                                                  Flattening or inversion of P waves

                                                                                                                                                                                                                  Torsades de pointes

                                                                                                                                                                                                                  Arrhythmia

                                                                                                                                                                                                                  Treatment

                                                                                                                                                                                                                  1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                                                  2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                                                  Message for Today

                                                                                                                                                                                                                  ICF

                                                                                                                                                                                                                  Interstitial

                                                                                                                                                                                                                  Pla

                                                                                                                                                                                                                  sma

                                                                                                                                                                                                                  5 Dex

                                                                                                                                                                                                                  bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                                                  • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                                                  • Slide 2
                                                                                                                                                                                                                  • Slide 3
                                                                                                                                                                                                                  • Slide 4
                                                                                                                                                                                                                  • Total Body Water
                                                                                                                                                                                                                  • Body Fluid Compartments
                                                                                                                                                                                                                  • Total body water (TBW)
                                                                                                                                                                                                                  • Body compartment fluid
                                                                                                                                                                                                                  • Example men with 70kg
                                                                                                                                                                                                                  • Fluid compartments
                                                                                                                                                                                                                  • Slide 11
                                                                                                                                                                                                                  • Slide 12
                                                                                                                                                                                                                  • Slide 13
                                                                                                                                                                                                                  • Slide 14
                                                                                                                                                                                                                  • Slide 15
                                                                                                                                                                                                                  • Colloid osmotic pressure
                                                                                                                                                                                                                  • Slide 17
                                                                                                                                                                                                                  • Slide 18
                                                                                                                                                                                                                  • Slide 19
                                                                                                                                                                                                                  • Cell Membrane
                                                                                                                                                                                                                  • Slide 21
                                                                                                                                                                                                                  • Slide 22
                                                                                                                                                                                                                  • Slide 23
                                                                                                                                                                                                                  • Slide 24
                                                                                                                                                                                                                  • Slide 25
                                                                                                                                                                                                                  • Composition of Fluid Compartments
                                                                                                                                                                                                                  • Composition of Body Fluids
                                                                                                                                                                                                                  • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                                                  • Reasons for fluid therapy
                                                                                                                                                                                                                  • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                                                  • محلولهای وریدی
                                                                                                                                                                                                                  • Fluids
                                                                                                                                                                                                                  • Slide 33
                                                                                                                                                                                                                  • Slide 34
                                                                                                                                                                                                                  • Slide 35
                                                                                                                                                                                                                  • Crystalloids
                                                                                                                                                                                                                  • Colloid Solutions
                                                                                                                                                                                                                  • رینگر لاکتات
                                                                                                                                                                                                                  • 09Nacl
                                                                                                                                                                                                                  • Postoperative (maintenance)
                                                                                                                                                                                                                  • Slide 41
                                                                                                                                                                                                                  • Preexisting fluid deficits
                                                                                                                                                                                                                  • Maintenance requirements
                                                                                                                                                                                                                  • Surgical fluid losses
                                                                                                                                                                                                                  • Third space loss
                                                                                                                                                                                                                  • Crystalloid solution
                                                                                                                                                                                                                  • Colloids
                                                                                                                                                                                                                  • Complications
                                                                                                                                                                                                                  • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                                                  • Colloid versus crystalloid solutions
                                                                                                                                                                                                                  • Transfusion consideration
                                                                                                                                                                                                                  • اختلال در حجم مایعات بدن
                                                                                                                                                                                                                  • Fluid volume deficit (FVD)
                                                                                                                                                                                                                  • DEHYDRATION
                                                                                                                                                                                                                  • علل کاهش حجم خارج سلولی
                                                                                                                                                                                                                  • Signs of Hypovolemia
                                                                                                                                                                                                                  • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                                                  • Signs of Hypervolemia
                                                                                                                                                                                                                  • Management of Hypervolemia
                                                                                                                                                                                                                  • Fluid Management
                                                                                                                                                                                                                  • Electrolyte physiology
                                                                                                                                                                                                                  • Sodium physiology
                                                                                                                                                                                                                  • Osmotic Pressure
                                                                                                                                                                                                                  • Concentration
                                                                                                                                                                                                                  • Hypernatremia
                                                                                                                                                                                                                  • - Hypernatremia
                                                                                                                                                                                                                  • Slide 67
                                                                                                                                                                                                                  • Slide 68
                                                                                                                                                                                                                  • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                                                  • Treatment
                                                                                                                                                                                                                  • Water deficit (L)= times TBW
                                                                                                                                                                                                                  • The rate of fluid administration
                                                                                                                                                                                                                  • Hyponatremia Nalt135mEqL
                                                                                                                                                                                                                  • Slide 74
                                                                                                                                                                                                                  • Sodium depletion
                                                                                                                                                                                                                  • Sodium dilution
                                                                                                                                                                                                                  • Sign and symptoms
                                                                                                                                                                                                                  • Slide 78
                                                                                                                                                                                                                  • Treatment
                                                                                                                                                                                                                  • Slide 80
                                                                                                                                                                                                                  • Slide 81
                                                                                                                                                                                                                  • Dose
                                                                                                                                                                                                                  • Potassium abnormalities
                                                                                                                                                                                                                  • Hyperkalemia
                                                                                                                                                                                                                  • Clinical manifestation of hyperkalemia
                                                                                                                                                                                                                  • Slide 86
                                                                                                                                                                                                                  • Slide 87
                                                                                                                                                                                                                  • Hypokalemia
                                                                                                                                                                                                                  • Potassium changes associated with alkalosis
                                                                                                                                                                                                                  • Slide 90
                                                                                                                                                                                                                  • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                                                  • Slide 92
                                                                                                                                                                                                                  • Calcium
                                                                                                                                                                                                                  • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                                                  • علائم هیپوکلسمی
                                                                                                                                                                                                                  • Slide 96
                                                                                                                                                                                                                  • Slide 97
                                                                                                                                                                                                                  • Slide 98
                                                                                                                                                                                                                  • Slide 99
                                                                                                                                                                                                                  • سایرعلائم
                                                                                                                                                                                                                  • درمان
                                                                                                                                                                                                                  • هيپركلسمي Cagt55meql
                                                                                                                                                                                                                  • علائم
                                                                                                                                                                                                                  • علائم قلبی
                                                                                                                                                                                                                  • Slide 105
                                                                                                                                                                                                                  • Magnesium Abnormalities
                                                                                                                                                                                                                  • منیزیوم
                                                                                                                                                                                                                  • Hypermagnesemia
                                                                                                                                                                                                                  • Clinical manifestation hypermanesemia
                                                                                                                                                                                                                  • Slide 110
                                                                                                                                                                                                                  • Slide 111
                                                                                                                                                                                                                  • Hypomagnesemia
                                                                                                                                                                                                                  • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                                                  • Slide 114
                                                                                                                                                                                                                  • Message for Today
                                                                                                                                                                                                                  • Slide 116

                                                                                                                                                                                                                    Hypomagnesemia

                                                                                                                                                                                                                    Calcium magnesium receptors on renal tubular cells is primarily responsible for mg

                                                                                                                                                                                                                    homeostasis

                                                                                                                                                                                                                    Etiology

                                                                                                                                                                                                                    1 Poor intake (starvation alcoholism prolonged use of IV fluids and TPN with

                                                                                                                                                                                                                    inadequate supplementation of magnesium)

                                                                                                                                                                                                                    2 Increased renal excretion (alcohol most diuretics and amphotericin B)

                                                                                                                                                                                                                    3 GI losses (diarrhea)

                                                                                                                                                                                                                    4 Malabsorption

                                                                                                                                                                                                                    5 Acute pancreatitis

                                                                                                                                                                                                                    6 Diabetic ketoacidosis

                                                                                                                                                                                                                    7 Primary aldosteronism

                                                                                                                                                                                                                    Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                                                    1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                                                    2 Delirium and seizures in severe deficiency

                                                                                                                                                                                                                    3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                                                    ST-segment depression

                                                                                                                                                                                                                    Flattening or inversion of P waves

                                                                                                                                                                                                                    Torsades de pointes

                                                                                                                                                                                                                    Arrhythmia

                                                                                                                                                                                                                    Treatment

                                                                                                                                                                                                                    1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                                                    2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                                                    Message for Today

                                                                                                                                                                                                                    ICF

                                                                                                                                                                                                                    Interstitial

                                                                                                                                                                                                                    Pla

                                                                                                                                                                                                                    sma

                                                                                                                                                                                                                    5 Dex

                                                                                                                                                                                                                    bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                                                    • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                                                    • Slide 2
                                                                                                                                                                                                                    • Slide 3
                                                                                                                                                                                                                    • Slide 4
                                                                                                                                                                                                                    • Total Body Water
                                                                                                                                                                                                                    • Body Fluid Compartments
                                                                                                                                                                                                                    • Total body water (TBW)
                                                                                                                                                                                                                    • Body compartment fluid
                                                                                                                                                                                                                    • Example men with 70kg
                                                                                                                                                                                                                    • Fluid compartments
                                                                                                                                                                                                                    • Slide 11
                                                                                                                                                                                                                    • Slide 12
                                                                                                                                                                                                                    • Slide 13
                                                                                                                                                                                                                    • Slide 14
                                                                                                                                                                                                                    • Slide 15
                                                                                                                                                                                                                    • Colloid osmotic pressure
                                                                                                                                                                                                                    • Slide 17
                                                                                                                                                                                                                    • Slide 18
                                                                                                                                                                                                                    • Slide 19
                                                                                                                                                                                                                    • Cell Membrane
                                                                                                                                                                                                                    • Slide 21
                                                                                                                                                                                                                    • Slide 22
                                                                                                                                                                                                                    • Slide 23
                                                                                                                                                                                                                    • Slide 24
                                                                                                                                                                                                                    • Slide 25
                                                                                                                                                                                                                    • Composition of Fluid Compartments
                                                                                                                                                                                                                    • Composition of Body Fluids
                                                                                                                                                                                                                    • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                                                    • Reasons for fluid therapy
                                                                                                                                                                                                                    • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                                                    • محلولهای وریدی
                                                                                                                                                                                                                    • Fluids
                                                                                                                                                                                                                    • Slide 33
                                                                                                                                                                                                                    • Slide 34
                                                                                                                                                                                                                    • Slide 35
                                                                                                                                                                                                                    • Crystalloids
                                                                                                                                                                                                                    • Colloid Solutions
                                                                                                                                                                                                                    • رینگر لاکتات
                                                                                                                                                                                                                    • 09Nacl
                                                                                                                                                                                                                    • Postoperative (maintenance)
                                                                                                                                                                                                                    • Slide 41
                                                                                                                                                                                                                    • Preexisting fluid deficits
                                                                                                                                                                                                                    • Maintenance requirements
                                                                                                                                                                                                                    • Surgical fluid losses
                                                                                                                                                                                                                    • Third space loss
                                                                                                                                                                                                                    • Crystalloid solution
                                                                                                                                                                                                                    • Colloids
                                                                                                                                                                                                                    • Complications
                                                                                                                                                                                                                    • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                                                    • Colloid versus crystalloid solutions
                                                                                                                                                                                                                    • Transfusion consideration
                                                                                                                                                                                                                    • اختلال در حجم مایعات بدن
                                                                                                                                                                                                                    • Fluid volume deficit (FVD)
                                                                                                                                                                                                                    • DEHYDRATION
                                                                                                                                                                                                                    • علل کاهش حجم خارج سلولی
                                                                                                                                                                                                                    • Signs of Hypovolemia
                                                                                                                                                                                                                    • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                                                    • Signs of Hypervolemia
                                                                                                                                                                                                                    • Management of Hypervolemia
                                                                                                                                                                                                                    • Fluid Management
                                                                                                                                                                                                                    • Electrolyte physiology
                                                                                                                                                                                                                    • Sodium physiology
                                                                                                                                                                                                                    • Osmotic Pressure
                                                                                                                                                                                                                    • Concentration
                                                                                                                                                                                                                    • Hypernatremia
                                                                                                                                                                                                                    • - Hypernatremia
                                                                                                                                                                                                                    • Slide 67
                                                                                                                                                                                                                    • Slide 68
                                                                                                                                                                                                                    • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                                                    • Treatment
                                                                                                                                                                                                                    • Water deficit (L)= times TBW
                                                                                                                                                                                                                    • The rate of fluid administration
                                                                                                                                                                                                                    • Hyponatremia Nalt135mEqL
                                                                                                                                                                                                                    • Slide 74
                                                                                                                                                                                                                    • Sodium depletion
                                                                                                                                                                                                                    • Sodium dilution
                                                                                                                                                                                                                    • Sign and symptoms
                                                                                                                                                                                                                    • Slide 78
                                                                                                                                                                                                                    • Treatment
                                                                                                                                                                                                                    • Slide 80
                                                                                                                                                                                                                    • Slide 81
                                                                                                                                                                                                                    • Dose
                                                                                                                                                                                                                    • Potassium abnormalities
                                                                                                                                                                                                                    • Hyperkalemia
                                                                                                                                                                                                                    • Clinical manifestation of hyperkalemia
                                                                                                                                                                                                                    • Slide 86
                                                                                                                                                                                                                    • Slide 87
                                                                                                                                                                                                                    • Hypokalemia
                                                                                                                                                                                                                    • Potassium changes associated with alkalosis
                                                                                                                                                                                                                    • Slide 90
                                                                                                                                                                                                                    • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                                                    • Slide 92
                                                                                                                                                                                                                    • Calcium
                                                                                                                                                                                                                    • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                                                    • علائم هیپوکلسمی
                                                                                                                                                                                                                    • Slide 96
                                                                                                                                                                                                                    • Slide 97
                                                                                                                                                                                                                    • Slide 98
                                                                                                                                                                                                                    • Slide 99
                                                                                                                                                                                                                    • سایرعلائم
                                                                                                                                                                                                                    • درمان
                                                                                                                                                                                                                    • هيپركلسمي Cagt55meql
                                                                                                                                                                                                                    • علائم
                                                                                                                                                                                                                    • علائم قلبی
                                                                                                                                                                                                                    • Slide 105
                                                                                                                                                                                                                    • Magnesium Abnormalities
                                                                                                                                                                                                                    • منیزیوم
                                                                                                                                                                                                                    • Hypermagnesemia
                                                                                                                                                                                                                    • Clinical manifestation hypermanesemia
                                                                                                                                                                                                                    • Slide 110
                                                                                                                                                                                                                    • Slide 111
                                                                                                                                                                                                                    • Hypomagnesemia
                                                                                                                                                                                                                    • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                                                    • Slide 114
                                                                                                                                                                                                                    • Message for Today
                                                                                                                                                                                                                    • Slide 116

                                                                                                                                                                                                                      Clinical manifestation of hypomagnesemia(similar to hypocalcemia)

                                                                                                                                                                                                                      1 Hyper active reflexes muscle tremors tetany with chevostekrsquos sign

                                                                                                                                                                                                                      2 Delirium and seizures in severe deficiency

                                                                                                                                                                                                                      3 ECG changes Prolonged QT and PR interval

                                                                                                                                                                                                                      ST-segment depression

                                                                                                                                                                                                                      Flattening or inversion of P waves

                                                                                                                                                                                                                      Torsades de pointes

                                                                                                                                                                                                                      Arrhythmia

                                                                                                                                                                                                                      Treatment

                                                                                                                                                                                                                      1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                                                      2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                                                      Message for Today

                                                                                                                                                                                                                      ICF

                                                                                                                                                                                                                      Interstitial

                                                                                                                                                                                                                      Pla

                                                                                                                                                                                                                      sma

                                                                                                                                                                                                                      5 Dex

                                                                                                                                                                                                                      bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                                                      • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                                                      • Slide 2
                                                                                                                                                                                                                      • Slide 3
                                                                                                                                                                                                                      • Slide 4
                                                                                                                                                                                                                      • Total Body Water
                                                                                                                                                                                                                      • Body Fluid Compartments
                                                                                                                                                                                                                      • Total body water (TBW)
                                                                                                                                                                                                                      • Body compartment fluid
                                                                                                                                                                                                                      • Example men with 70kg
                                                                                                                                                                                                                      • Fluid compartments
                                                                                                                                                                                                                      • Slide 11
                                                                                                                                                                                                                      • Slide 12
                                                                                                                                                                                                                      • Slide 13
                                                                                                                                                                                                                      • Slide 14
                                                                                                                                                                                                                      • Slide 15
                                                                                                                                                                                                                      • Colloid osmotic pressure
                                                                                                                                                                                                                      • Slide 17
                                                                                                                                                                                                                      • Slide 18
                                                                                                                                                                                                                      • Slide 19
                                                                                                                                                                                                                      • Cell Membrane
                                                                                                                                                                                                                      • Slide 21
                                                                                                                                                                                                                      • Slide 22
                                                                                                                                                                                                                      • Slide 23
                                                                                                                                                                                                                      • Slide 24
                                                                                                                                                                                                                      • Slide 25
                                                                                                                                                                                                                      • Composition of Fluid Compartments
                                                                                                                                                                                                                      • Composition of Body Fluids
                                                                                                                                                                                                                      • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                                                      • Reasons for fluid therapy
                                                                                                                                                                                                                      • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                                                      • محلولهای وریدی
                                                                                                                                                                                                                      • Fluids
                                                                                                                                                                                                                      • Slide 33
                                                                                                                                                                                                                      • Slide 34
                                                                                                                                                                                                                      • Slide 35
                                                                                                                                                                                                                      • Crystalloids
                                                                                                                                                                                                                      • Colloid Solutions
                                                                                                                                                                                                                      • رینگر لاکتات
                                                                                                                                                                                                                      • 09Nacl
                                                                                                                                                                                                                      • Postoperative (maintenance)
                                                                                                                                                                                                                      • Slide 41
                                                                                                                                                                                                                      • Preexisting fluid deficits
                                                                                                                                                                                                                      • Maintenance requirements
                                                                                                                                                                                                                      • Surgical fluid losses
                                                                                                                                                                                                                      • Third space loss
                                                                                                                                                                                                                      • Crystalloid solution
                                                                                                                                                                                                                      • Colloids
                                                                                                                                                                                                                      • Complications
                                                                                                                                                                                                                      • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                                                      • Colloid versus crystalloid solutions
                                                                                                                                                                                                                      • Transfusion consideration
                                                                                                                                                                                                                      • اختلال در حجم مایعات بدن
                                                                                                                                                                                                                      • Fluid volume deficit (FVD)
                                                                                                                                                                                                                      • DEHYDRATION
                                                                                                                                                                                                                      • علل کاهش حجم خارج سلولی
                                                                                                                                                                                                                      • Signs of Hypovolemia
                                                                                                                                                                                                                      • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                                                      • Signs of Hypervolemia
                                                                                                                                                                                                                      • Management of Hypervolemia
                                                                                                                                                                                                                      • Fluid Management
                                                                                                                                                                                                                      • Electrolyte physiology
                                                                                                                                                                                                                      • Sodium physiology
                                                                                                                                                                                                                      • Osmotic Pressure
                                                                                                                                                                                                                      • Concentration
                                                                                                                                                                                                                      • Hypernatremia
                                                                                                                                                                                                                      • - Hypernatremia
                                                                                                                                                                                                                      • Slide 67
                                                                                                                                                                                                                      • Slide 68
                                                                                                                                                                                                                      • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                                                      • Treatment
                                                                                                                                                                                                                      • Water deficit (L)= times TBW
                                                                                                                                                                                                                      • The rate of fluid administration
                                                                                                                                                                                                                      • Hyponatremia Nalt135mEqL
                                                                                                                                                                                                                      • Slide 74
                                                                                                                                                                                                                      • Sodium depletion
                                                                                                                                                                                                                      • Sodium dilution
                                                                                                                                                                                                                      • Sign and symptoms
                                                                                                                                                                                                                      • Slide 78
                                                                                                                                                                                                                      • Treatment
                                                                                                                                                                                                                      • Slide 80
                                                                                                                                                                                                                      • Slide 81
                                                                                                                                                                                                                      • Dose
                                                                                                                                                                                                                      • Potassium abnormalities
                                                                                                                                                                                                                      • Hyperkalemia
                                                                                                                                                                                                                      • Clinical manifestation of hyperkalemia
                                                                                                                                                                                                                      • Slide 86
                                                                                                                                                                                                                      • Slide 87
                                                                                                                                                                                                                      • Hypokalemia
                                                                                                                                                                                                                      • Potassium changes associated with alkalosis
                                                                                                                                                                                                                      • Slide 90
                                                                                                                                                                                                                      • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                                                      • Slide 92
                                                                                                                                                                                                                      • Calcium
                                                                                                                                                                                                                      • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                                                      • علائم هیپوکلسمی
                                                                                                                                                                                                                      • Slide 96
                                                                                                                                                                                                                      • Slide 97
                                                                                                                                                                                                                      • Slide 98
                                                                                                                                                                                                                      • Slide 99
                                                                                                                                                                                                                      • سایرعلائم
                                                                                                                                                                                                                      • درمان
                                                                                                                                                                                                                      • هيپركلسمي Cagt55meql
                                                                                                                                                                                                                      • علائم
                                                                                                                                                                                                                      • علائم قلبی
                                                                                                                                                                                                                      • Slide 105
                                                                                                                                                                                                                      • Magnesium Abnormalities
                                                                                                                                                                                                                      • منیزیوم
                                                                                                                                                                                                                      • Hypermagnesemia
                                                                                                                                                                                                                      • Clinical manifestation hypermanesemia
                                                                                                                                                                                                                      • Slide 110
                                                                                                                                                                                                                      • Slide 111
                                                                                                                                                                                                                      • Hypomagnesemia
                                                                                                                                                                                                                      • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                                                      • Slide 114
                                                                                                                                                                                                                      • Message for Today
                                                                                                                                                                                                                      • Slide 116

                                                                                                                                                                                                                        Treatment

                                                                                                                                                                                                                        1 For asymptomatic and mild hypomagnesemia administer oral mg

                                                                                                                                                                                                                        2 For severe deficit (lt1meqL) or symptomatic patient administer 1 to 2 g of mg-sulfate IV over 2 minute (simultaneous with ca-gluconate)

                                                                                                                                                                                                                        Message for Today

                                                                                                                                                                                                                        ICF

                                                                                                                                                                                                                        Interstitial

                                                                                                                                                                                                                        Pla

                                                                                                                                                                                                                        sma

                                                                                                                                                                                                                        5 Dex

                                                                                                                                                                                                                        bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                                                        • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                                                        • Slide 2
                                                                                                                                                                                                                        • Slide 3
                                                                                                                                                                                                                        • Slide 4
                                                                                                                                                                                                                        • Total Body Water
                                                                                                                                                                                                                        • Body Fluid Compartments
                                                                                                                                                                                                                        • Total body water (TBW)
                                                                                                                                                                                                                        • Body compartment fluid
                                                                                                                                                                                                                        • Example men with 70kg
                                                                                                                                                                                                                        • Fluid compartments
                                                                                                                                                                                                                        • Slide 11
                                                                                                                                                                                                                        • Slide 12
                                                                                                                                                                                                                        • Slide 13
                                                                                                                                                                                                                        • Slide 14
                                                                                                                                                                                                                        • Slide 15
                                                                                                                                                                                                                        • Colloid osmotic pressure
                                                                                                                                                                                                                        • Slide 17
                                                                                                                                                                                                                        • Slide 18
                                                                                                                                                                                                                        • Slide 19
                                                                                                                                                                                                                        • Cell Membrane
                                                                                                                                                                                                                        • Slide 21
                                                                                                                                                                                                                        • Slide 22
                                                                                                                                                                                                                        • Slide 23
                                                                                                                                                                                                                        • Slide 24
                                                                                                                                                                                                                        • Slide 25
                                                                                                                                                                                                                        • Composition of Fluid Compartments
                                                                                                                                                                                                                        • Composition of Body Fluids
                                                                                                                                                                                                                        • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                                                        • Reasons for fluid therapy
                                                                                                                                                                                                                        • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                                                        • محلولهای وریدی
                                                                                                                                                                                                                        • Fluids
                                                                                                                                                                                                                        • Slide 33
                                                                                                                                                                                                                        • Slide 34
                                                                                                                                                                                                                        • Slide 35
                                                                                                                                                                                                                        • Crystalloids
                                                                                                                                                                                                                        • Colloid Solutions
                                                                                                                                                                                                                        • رینگر لاکتات
                                                                                                                                                                                                                        • 09Nacl
                                                                                                                                                                                                                        • Postoperative (maintenance)
                                                                                                                                                                                                                        • Slide 41
                                                                                                                                                                                                                        • Preexisting fluid deficits
                                                                                                                                                                                                                        • Maintenance requirements
                                                                                                                                                                                                                        • Surgical fluid losses
                                                                                                                                                                                                                        • Third space loss
                                                                                                                                                                                                                        • Crystalloid solution
                                                                                                                                                                                                                        • Colloids
                                                                                                                                                                                                                        • Complications
                                                                                                                                                                                                                        • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                                                        • Colloid versus crystalloid solutions
                                                                                                                                                                                                                        • Transfusion consideration
                                                                                                                                                                                                                        • اختلال در حجم مایعات بدن
                                                                                                                                                                                                                        • Fluid volume deficit (FVD)
                                                                                                                                                                                                                        • DEHYDRATION
                                                                                                                                                                                                                        • علل کاهش حجم خارج سلولی
                                                                                                                                                                                                                        • Signs of Hypovolemia
                                                                                                                                                                                                                        • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                                                        • Signs of Hypervolemia
                                                                                                                                                                                                                        • Management of Hypervolemia
                                                                                                                                                                                                                        • Fluid Management
                                                                                                                                                                                                                        • Electrolyte physiology
                                                                                                                                                                                                                        • Sodium physiology
                                                                                                                                                                                                                        • Osmotic Pressure
                                                                                                                                                                                                                        • Concentration
                                                                                                                                                                                                                        • Hypernatremia
                                                                                                                                                                                                                        • - Hypernatremia
                                                                                                                                                                                                                        • Slide 67
                                                                                                                                                                                                                        • Slide 68
                                                                                                                                                                                                                        • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                                                        • Treatment
                                                                                                                                                                                                                        • Water deficit (L)= times TBW
                                                                                                                                                                                                                        • The rate of fluid administration
                                                                                                                                                                                                                        • Hyponatremia Nalt135mEqL
                                                                                                                                                                                                                        • Slide 74
                                                                                                                                                                                                                        • Sodium depletion
                                                                                                                                                                                                                        • Sodium dilution
                                                                                                                                                                                                                        • Sign and symptoms
                                                                                                                                                                                                                        • Slide 78
                                                                                                                                                                                                                        • Treatment
                                                                                                                                                                                                                        • Slide 80
                                                                                                                                                                                                                        • Slide 81
                                                                                                                                                                                                                        • Dose
                                                                                                                                                                                                                        • Potassium abnormalities
                                                                                                                                                                                                                        • Hyperkalemia
                                                                                                                                                                                                                        • Clinical manifestation of hyperkalemia
                                                                                                                                                                                                                        • Slide 86
                                                                                                                                                                                                                        • Slide 87
                                                                                                                                                                                                                        • Hypokalemia
                                                                                                                                                                                                                        • Potassium changes associated with alkalosis
                                                                                                                                                                                                                        • Slide 90
                                                                                                                                                                                                                        • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                                                        • Slide 92
                                                                                                                                                                                                                        • Calcium
                                                                                                                                                                                                                        • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                                                        • علائم هیپوکلسمی
                                                                                                                                                                                                                        • Slide 96
                                                                                                                                                                                                                        • Slide 97
                                                                                                                                                                                                                        • Slide 98
                                                                                                                                                                                                                        • Slide 99
                                                                                                                                                                                                                        • سایرعلائم
                                                                                                                                                                                                                        • درمان
                                                                                                                                                                                                                        • هيپركلسمي Cagt55meql
                                                                                                                                                                                                                        • علائم
                                                                                                                                                                                                                        • علائم قلبی
                                                                                                                                                                                                                        • Slide 105
                                                                                                                                                                                                                        • Magnesium Abnormalities
                                                                                                                                                                                                                        • منیزیوم
                                                                                                                                                                                                                        • Hypermagnesemia
                                                                                                                                                                                                                        • Clinical manifestation hypermanesemia
                                                                                                                                                                                                                        • Slide 110
                                                                                                                                                                                                                        • Slide 111
                                                                                                                                                                                                                        • Hypomagnesemia
                                                                                                                                                                                                                        • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                                                        • Slide 114
                                                                                                                                                                                                                        • Message for Today
                                                                                                                                                                                                                        • Slide 116

                                                                                                                                                                                                                          Message for Today

                                                                                                                                                                                                                          ICF

                                                                                                                                                                                                                          Interstitial

                                                                                                                                                                                                                          Pla

                                                                                                                                                                                                                          sma

                                                                                                                                                                                                                          5 Dex

                                                                                                                                                                                                                          bull Do not reccussitate sick patients with any Dextrose solution

                                                                                                                                                                                                                          • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                                                          • Slide 2
                                                                                                                                                                                                                          • Slide 3
                                                                                                                                                                                                                          • Slide 4
                                                                                                                                                                                                                          • Total Body Water
                                                                                                                                                                                                                          • Body Fluid Compartments
                                                                                                                                                                                                                          • Total body water (TBW)
                                                                                                                                                                                                                          • Body compartment fluid
                                                                                                                                                                                                                          • Example men with 70kg
                                                                                                                                                                                                                          • Fluid compartments
                                                                                                                                                                                                                          • Slide 11
                                                                                                                                                                                                                          • Slide 12
                                                                                                                                                                                                                          • Slide 13
                                                                                                                                                                                                                          • Slide 14
                                                                                                                                                                                                                          • Slide 15
                                                                                                                                                                                                                          • Colloid osmotic pressure
                                                                                                                                                                                                                          • Slide 17
                                                                                                                                                                                                                          • Slide 18
                                                                                                                                                                                                                          • Slide 19
                                                                                                                                                                                                                          • Cell Membrane
                                                                                                                                                                                                                          • Slide 21
                                                                                                                                                                                                                          • Slide 22
                                                                                                                                                                                                                          • Slide 23
                                                                                                                                                                                                                          • Slide 24
                                                                                                                                                                                                                          • Slide 25
                                                                                                                                                                                                                          • Composition of Fluid Compartments
                                                                                                                                                                                                                          • Composition of Body Fluids
                                                                                                                                                                                                                          • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                                                          • Reasons for fluid therapy
                                                                                                                                                                                                                          • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                                                          • محلولهای وریدی
                                                                                                                                                                                                                          • Fluids
                                                                                                                                                                                                                          • Slide 33
                                                                                                                                                                                                                          • Slide 34
                                                                                                                                                                                                                          • Slide 35
                                                                                                                                                                                                                          • Crystalloids
                                                                                                                                                                                                                          • Colloid Solutions
                                                                                                                                                                                                                          • رینگر لاکتات
                                                                                                                                                                                                                          • 09Nacl
                                                                                                                                                                                                                          • Postoperative (maintenance)
                                                                                                                                                                                                                          • Slide 41
                                                                                                                                                                                                                          • Preexisting fluid deficits
                                                                                                                                                                                                                          • Maintenance requirements
                                                                                                                                                                                                                          • Surgical fluid losses
                                                                                                                                                                                                                          • Third space loss
                                                                                                                                                                                                                          • Crystalloid solution
                                                                                                                                                                                                                          • Colloids
                                                                                                                                                                                                                          • Complications
                                                                                                                                                                                                                          • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                                                          • Colloid versus crystalloid solutions
                                                                                                                                                                                                                          • Transfusion consideration
                                                                                                                                                                                                                          • اختلال در حجم مایعات بدن
                                                                                                                                                                                                                          • Fluid volume deficit (FVD)
                                                                                                                                                                                                                          • DEHYDRATION
                                                                                                                                                                                                                          • علل کاهش حجم خارج سلولی
                                                                                                                                                                                                                          • Signs of Hypovolemia
                                                                                                                                                                                                                          • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                                                          • Signs of Hypervolemia
                                                                                                                                                                                                                          • Management of Hypervolemia
                                                                                                                                                                                                                          • Fluid Management
                                                                                                                                                                                                                          • Electrolyte physiology
                                                                                                                                                                                                                          • Sodium physiology
                                                                                                                                                                                                                          • Osmotic Pressure
                                                                                                                                                                                                                          • Concentration
                                                                                                                                                                                                                          • Hypernatremia
                                                                                                                                                                                                                          • - Hypernatremia
                                                                                                                                                                                                                          • Slide 67
                                                                                                                                                                                                                          • Slide 68
                                                                                                                                                                                                                          • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                                                          • Treatment
                                                                                                                                                                                                                          • Water deficit (L)= times TBW
                                                                                                                                                                                                                          • The rate of fluid administration
                                                                                                                                                                                                                          • Hyponatremia Nalt135mEqL
                                                                                                                                                                                                                          • Slide 74
                                                                                                                                                                                                                          • Sodium depletion
                                                                                                                                                                                                                          • Sodium dilution
                                                                                                                                                                                                                          • Sign and symptoms
                                                                                                                                                                                                                          • Slide 78
                                                                                                                                                                                                                          • Treatment
                                                                                                                                                                                                                          • Slide 80
                                                                                                                                                                                                                          • Slide 81
                                                                                                                                                                                                                          • Dose
                                                                                                                                                                                                                          • Potassium abnormalities
                                                                                                                                                                                                                          • Hyperkalemia
                                                                                                                                                                                                                          • Clinical manifestation of hyperkalemia
                                                                                                                                                                                                                          • Slide 86
                                                                                                                                                                                                                          • Slide 87
                                                                                                                                                                                                                          • Hypokalemia
                                                                                                                                                                                                                          • Potassium changes associated with alkalosis
                                                                                                                                                                                                                          • Slide 90
                                                                                                                                                                                                                          • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                                                          • Slide 92
                                                                                                                                                                                                                          • Calcium
                                                                                                                                                                                                                          • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                                                          • علائم هیپوکلسمی
                                                                                                                                                                                                                          • Slide 96
                                                                                                                                                                                                                          • Slide 97
                                                                                                                                                                                                                          • Slide 98
                                                                                                                                                                                                                          • Slide 99
                                                                                                                                                                                                                          • سایرعلائم
                                                                                                                                                                                                                          • درمان
                                                                                                                                                                                                                          • هيپركلسمي Cagt55meql
                                                                                                                                                                                                                          • علائم
                                                                                                                                                                                                                          • علائم قلبی
                                                                                                                                                                                                                          • Slide 105
                                                                                                                                                                                                                          • Magnesium Abnormalities
                                                                                                                                                                                                                          • منیزیوم
                                                                                                                                                                                                                          • Hypermagnesemia
                                                                                                                                                                                                                          • Clinical manifestation hypermanesemia
                                                                                                                                                                                                                          • Slide 110
                                                                                                                                                                                                                          • Slide 111
                                                                                                                                                                                                                          • Hypomagnesemia
                                                                                                                                                                                                                          • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                                                          • Slide 114
                                                                                                                                                                                                                          • Message for Today
                                                                                                                                                                                                                          • Slide 116
                                                                                                                                                                                                                            • Fluid and Electrolyte Management of the Surgical Patient
                                                                                                                                                                                                                            • Slide 2
                                                                                                                                                                                                                            • Slide 3
                                                                                                                                                                                                                            • Slide 4
                                                                                                                                                                                                                            • Total Body Water
                                                                                                                                                                                                                            • Body Fluid Compartments
                                                                                                                                                                                                                            • Total body water (TBW)
                                                                                                                                                                                                                            • Body compartment fluid
                                                                                                                                                                                                                            • Example men with 70kg
                                                                                                                                                                                                                            • Fluid compartments
                                                                                                                                                                                                                            • Slide 11
                                                                                                                                                                                                                            • Slide 12
                                                                                                                                                                                                                            • Slide 13
                                                                                                                                                                                                                            • Slide 14
                                                                                                                                                                                                                            • Slide 15
                                                                                                                                                                                                                            • Colloid osmotic pressure
                                                                                                                                                                                                                            • Slide 17
                                                                                                                                                                                                                            • Slide 18
                                                                                                                                                                                                                            • Slide 19
                                                                                                                                                                                                                            • Cell Membrane
                                                                                                                                                                                                                            • Slide 21
                                                                                                                                                                                                                            • Slide 22
                                                                                                                                                                                                                            • Slide 23
                                                                                                                                                                                                                            • Slide 24
                                                                                                                                                                                                                            • Slide 25
                                                                                                                                                                                                                            • Composition of Fluid Compartments
                                                                                                                                                                                                                            • Composition of Body Fluids
                                                                                                                                                                                                                            • عوامل موثر روی تغییرات آب والکترولیت
                                                                                                                                                                                                                            • Reasons for fluid therapy
                                                                                                                                                                                                                            • ارزیابی حجم مایع داخل عروقی
                                                                                                                                                                                                                            • محلولهای وریدی
                                                                                                                                                                                                                            • Fluids
                                                                                                                                                                                                                            • Slide 33
                                                                                                                                                                                                                            • Slide 34
                                                                                                                                                                                                                            • Slide 35
                                                                                                                                                                                                                            • Crystalloids
                                                                                                                                                                                                                            • Colloid Solutions
                                                                                                                                                                                                                            • رینگر لاکتات
                                                                                                                                                                                                                            • 09Nacl
                                                                                                                                                                                                                            • Postoperative (maintenance)
                                                                                                                                                                                                                            • Slide 41
                                                                                                                                                                                                                            • Preexisting fluid deficits
                                                                                                                                                                                                                            • Maintenance requirements
                                                                                                                                                                                                                            • Surgical fluid losses
                                                                                                                                                                                                                            • Third space loss
                                                                                                                                                                                                                            • Crystalloid solution
                                                                                                                                                                                                                            • Colloids
                                                                                                                                                                                                                            • Complications
                                                                                                                                                                                                                            • The Influence of Colloid amp Crystalloid on Blood Volume
                                                                                                                                                                                                                            • Colloid versus crystalloid solutions
                                                                                                                                                                                                                            • Transfusion consideration
                                                                                                                                                                                                                            • اختلال در حجم مایعات بدن
                                                                                                                                                                                                                            • Fluid volume deficit (FVD)
                                                                                                                                                                                                                            • DEHYDRATION
                                                                                                                                                                                                                            • علل کاهش حجم خارج سلولی
                                                                                                                                                                                                                            • Signs of Hypovolemia
                                                                                                                                                                                                                            • Clinical Diagnosis of Hypovolemia
                                                                                                                                                                                                                            • Signs of Hypervolemia
                                                                                                                                                                                                                            • Management of Hypervolemia
                                                                                                                                                                                                                            • Fluid Management
                                                                                                                                                                                                                            • Electrolyte physiology
                                                                                                                                                                                                                            • Sodium physiology
                                                                                                                                                                                                                            • Osmotic Pressure
                                                                                                                                                                                                                            • Concentration
                                                                                                                                                                                                                            • Hypernatremia
                                                                                                                                                                                                                            • - Hypernatremia
                                                                                                                                                                                                                            • Slide 67
                                                                                                                                                                                                                            • Slide 68
                                                                                                                                                                                                                            • Clinical Manifestations of Abnormalities in Serum Sodium
                                                                                                                                                                                                                            • Treatment
                                                                                                                                                                                                                            • Water deficit (L)= times TBW
                                                                                                                                                                                                                            • The rate of fluid administration
                                                                                                                                                                                                                            • Hyponatremia Nalt135mEqL
                                                                                                                                                                                                                            • Slide 74
                                                                                                                                                                                                                            • Sodium depletion
                                                                                                                                                                                                                            • Sodium dilution
                                                                                                                                                                                                                            • Sign and symptoms
                                                                                                                                                                                                                            • Slide 78
                                                                                                                                                                                                                            • Treatment
                                                                                                                                                                                                                            • Slide 80
                                                                                                                                                                                                                            • Slide 81
                                                                                                                                                                                                                            • Dose
                                                                                                                                                                                                                            • Potassium abnormalities
                                                                                                                                                                                                                            • Hyperkalemia
                                                                                                                                                                                                                            • Clinical manifestation of hyperkalemia
                                                                                                                                                                                                                            • Slide 86
                                                                                                                                                                                                                            • Slide 87
                                                                                                                                                                                                                            • Hypokalemia
                                                                                                                                                                                                                            • Potassium changes associated with alkalosis
                                                                                                                                                                                                                            • Slide 90
                                                                                                                                                                                                                            • Clinical Manifestation of Abnormalities in potassium
                                                                                                                                                                                                                            • Slide 92
                                                                                                                                                                                                                            • Calcium
                                                                                                                                                                                                                            • هيپوكلسمي یونیزه Calt45 meql
                                                                                                                                                                                                                            • علائم هیپوکلسمی
                                                                                                                                                                                                                            • Slide 96
                                                                                                                                                                                                                            • Slide 97
                                                                                                                                                                                                                            • Slide 98
                                                                                                                                                                                                                            • Slide 99
                                                                                                                                                                                                                            • سایرعلائم
                                                                                                                                                                                                                            • درمان
                                                                                                                                                                                                                            • هيپركلسمي Cagt55meql
                                                                                                                                                                                                                            • علائم
                                                                                                                                                                                                                            • علائم قلبی
                                                                                                                                                                                                                            • Slide 105
                                                                                                                                                                                                                            • Magnesium Abnormalities
                                                                                                                                                                                                                            • منیزیوم
                                                                                                                                                                                                                            • Hypermagnesemia
                                                                                                                                                                                                                            • Clinical manifestation hypermanesemia
                                                                                                                                                                                                                            • Slide 110
                                                                                                                                                                                                                            • Slide 111
                                                                                                                                                                                                                            • Hypomagnesemia
                                                                                                                                                                                                                            • Clinical manifestation of hypomagnesemia (similar to hypocalcemia)
                                                                                                                                                                                                                            • Slide 114
                                                                                                                                                                                                                            • Message for Today
                                                                                                                                                                                                                            • Slide 116

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